Rita Antonelli, O. Paes de Almeida, R. Bologna-Molina, M. Meleti
Background. Sialadenoma papilliferum (SP) is a rare benign epithelial tumor of salivary gland origin, its diagnosis being potentially challenging. It was first described by Abrams and Finck in 1969 as an analog of the cutaneous syringocystadenoma papilliferum. The aim of this comprehensive review is to highlight the clinical and histopathological diagnostic aspects of intraoral SP, analyzing cases previously described and reporting new cases. Methods. Medline, Scopus, and Web of Science were searched up to February 2022, using as entry term “sialadenoma papilliferum”. No time limits were applied and only studies in English were taken into account. Only cases involving the mouth were included. Conference proceedings, personal communications, and letters to the editor were excluded. Results. In total, 42 out of 234 articles fulfilled the inclusion criteria, with 64 cases reported. Mean age of patients with SP was 57.2 years, with a higher prevalence among males. The most affected site was the palate, particularly the hard palate. Four cases with uncertain malignant features have been reported. While clinical manifestations of SP are rather unspecific (e.g., submucosal swelling with ulceration), histopathological and immunohistochemical features are quite peculiar, SP have a limited growth potential, leading to conservative excision as treatment of choice. Conclusions. SP, though rare, should be taken into consideration in the differential diagnosis of intraoral swellings, particularly those located on the palate.
背景。摘要涎腺乳头状瘤(SP)是一种罕见的涎腺良性上皮肿瘤，其诊断具有潜在的挑战性。1969年，艾布拉姆斯和芬克首次将其描述为皮肤注射器囊腺瘤乳头状瘤的类似物。这篇综合综述的目的是强调口腔内SP的临床和组织病理学诊断方面，分析以前描述的病例和报告新的病例。方法。检索截止到2022年2月的Medline、Scopus和Web of Science，以“sialadenoma papilliferum”作为词条。没有时间限制，只考虑以英语进行的研究。只包括涉及口腔的病例。会议记录、个人通信和给编辑的信件不包括在内。结果。总共234篇文章中有42篇符合纳入标准，报告了64例。SP患者的平均年龄为57.2岁，男性患病率较高。受影响最严重的部位是上颚，尤其是硬腭。报告了4例恶性特征不明确的病例。由于SP的临床表现不明确(如粘膜下肿胀伴溃疡)，组织病理学和免疫组织化学特征十分特殊，SP生长潜力有限，因此选择保守性切除作为治疗方法。结论。SP虽然罕见，但在鉴别诊断口腔内肿胀时应考虑到，特别是那些位于上颚的。
{"title":"Intraoral Sialadenoma Papilliferum: A Comprehensive Review of the Literature with Emphasis on Clinical and Histopathological Diagnostic Features","authors":"Rita Antonelli, O. Paes de Almeida, R. Bologna-Molina, M. Meleti","doi":"10.3390/oral2030023","DOIUrl":"https://doi.org/10.3390/oral2030023","url":null,"abstract":"Background. Sialadenoma papilliferum (SP) is a rare benign epithelial tumor of salivary gland origin, its diagnosis being potentially challenging. It was first described by Abrams and Finck in 1969 as an analog of the cutaneous syringocystadenoma papilliferum. The aim of this comprehensive review is to highlight the clinical and histopathological diagnostic aspects of intraoral SP, analyzing cases previously described and reporting new cases. Methods. Medline, Scopus, and Web of Science were searched up to February 2022, using as entry term “sialadenoma papilliferum”. No time limits were applied and only studies in English were taken into account. Only cases involving the mouth were included. Conference proceedings, personal communications, and letters to the editor were excluded. Results. In total, 42 out of 234 articles fulfilled the inclusion criteria, with 64 cases reported. Mean age of patients with SP was 57.2 years, with a higher prevalence among males. The most affected site was the palate, particularly the hard palate. Four cases with uncertain malignant features have been reported. While clinical manifestations of SP are rather unspecific (e.g., submucosal swelling with ulceration), histopathological and immunohistochemical features are quite peculiar, SP have a limited growth potential, leading to conservative excision as treatment of choice. Conclusions. SP, though rare, should be taken into consideration in the differential diagnosis of intraoral swellings, particularly those located on the palate.","PeriodicalId":19616,"journal":{"name":"Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics","volume":"63 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91063497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
It is a great honor and privilege to present this Special Issue on “Cone-Beam Computed Tomography (CBCT) Imaging in Dentistry” [...]
这是一个非常荣幸和荣幸提出这个特刊的“锥形束计算机断层扫描(CBCT)成像在牙科”[…]
{"title":"Foreword to the Special Issue on Cone-Beam Computed Tomography Imaging in Dentistry","authors":"O. Almășan","doi":"10.3390/oral2030022","DOIUrl":"https://doi.org/10.3390/oral2030022","url":null,"abstract":"It is a great honor and privilege to present this Special Issue on “Cone-Beam Computed Tomography (CBCT) Imaging in Dentistry” [...]","PeriodicalId":19616,"journal":{"name":"Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74271695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Hedeșiu, D. Pavel, O. Almășan, Sorin Gheorghe Pavel, H. Hedesiu, D. Rafiroiu
The main objective was to examine the biomechanical behavior of the mandible under standardized trauma and to develop models of biomechanical responses when the mandible is subjected to various simulated impacts. A homogenous model based on the bone’s average mechanical properties was used. To simulate external loads on the mandible, forces on the chin, forces in an anteroposterior direction, and forces from the basilar edge were applied. To simulate mandibular biomechanics, we employed a model created in the ANSYS v19.0 software. The skull with the temporomandibular joint (TMJ) from the Grabcad website was used as the geometric mandibular model. We attempted to simulate the stresses developed in the mandible by impact forces. The amount of force (F) corresponded to the fall of a five-kilogram body (the head), from a height of two meters (F = 6666.7 N). The impact force was applied perpendicular to an arbitrary surface of an area of 10−3 m2. Impact on the chin region and lateral impact on the mandible, from the basilar edge to the gonion were examined. The investigated clinical situations were mandibular complete dentition; jaw with missing mandibular molars; missing third molar and first and second premolars; missing canine, third molar, first and second premolars, and complete edentation. In a normal bite, the highest stress was on the TMJ area. In case of impact on the chin, in complete edentation, a mandibular fracture occurred; in case of impact on the gonion, all stress values exceed the limit value above which the mandible in the condyle area may fracture.
{"title":"Three-Dimensional Finite Element Analysis on Mandibular Biomechanics Simulation under Normal and Traumatic Conditions","authors":"M. Hedeșiu, D. Pavel, O. Almășan, Sorin Gheorghe Pavel, H. Hedesiu, D. Rafiroiu","doi":"10.3390/oral2030021","DOIUrl":"https://doi.org/10.3390/oral2030021","url":null,"abstract":"The main objective was to examine the biomechanical behavior of the mandible under standardized trauma and to develop models of biomechanical responses when the mandible is subjected to various simulated impacts. A homogenous model based on the bone’s average mechanical properties was used. To simulate external loads on the mandible, forces on the chin, forces in an anteroposterior direction, and forces from the basilar edge were applied. To simulate mandibular biomechanics, we employed a model created in the ANSYS v19.0 software. The skull with the temporomandibular joint (TMJ) from the Grabcad website was used as the geometric mandibular model. We attempted to simulate the stresses developed in the mandible by impact forces. The amount of force (F) corresponded to the fall of a five-kilogram body (the head), from a height of two meters (F = 6666.7 N). The impact force was applied perpendicular to an arbitrary surface of an area of 10−3 m2. Impact on the chin region and lateral impact on the mandible, from the basilar edge to the gonion were examined. The investigated clinical situations were mandibular complete dentition; jaw with missing mandibular molars; missing third molar and first and second premolars; missing canine, third molar, first and second premolars, and complete edentation. In a normal bite, the highest stress was on the TMJ area. In case of impact on the chin, in complete edentation, a mandibular fracture occurred; in case of impact on the gonion, all stress values exceed the limit value above which the mandible in the condyle area may fracture.","PeriodicalId":19616,"journal":{"name":"Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75469805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shamiso Chakaipa, Sarah J. Prior, Sue Pearson, P. V. Van Dam
Patient experience has been acknowledged as a critical dimension of healthcare quality alongside patient safety and clinical effectiveness. However, patient experiences in complete removable denture wearing have not been well established qualitatively. The purpose of this review was to synthesize qualitative studies that investigated the experiences of people wearing removable dentures in order to gain a deeper understanding of the issues and their causes. Databases of PubMed, SCOPUS, and CINAHL were searched to assess articles published in English from 2010 to 2021 globally. Qualitative studies that reported on experiences of people wearing removable dentures were included. A total of ten studies were included. People who wear dentures expressed diversified experiences (both negative and positive), including physical, social, psychological processes, and affective responses. Furthermore, experiences were related to emotions, maintenance of dentures, hygiene, access to care, and cost. Those wearing implant retained dentures reported more positive experiences than those who wear conventional complete dentures. Denture wearing experiences is a complex phenomenon involving the patient in wholeness including their environment. Healthcare professionals should be considering a holistic approach when providing denture rehabilitation. There is a need to further explore denture wearing experiences using qualitative approaches, as understanding of patient experiences can inform and provide clear directions on quality improvement initiatives and health-care policy development.
{"title":"The Experiences of Patients Treated with Complete Removable Dentures: A Systematic Literature Review of Qualitative Research","authors":"Shamiso Chakaipa, Sarah J. Prior, Sue Pearson, P. V. Van Dam","doi":"10.3390/oral2030020","DOIUrl":"https://doi.org/10.3390/oral2030020","url":null,"abstract":"Patient experience has been acknowledged as a critical dimension of healthcare quality alongside patient safety and clinical effectiveness. However, patient experiences in complete removable denture wearing have not been well established qualitatively. The purpose of this review was to synthesize qualitative studies that investigated the experiences of people wearing removable dentures in order to gain a deeper understanding of the issues and their causes. Databases of PubMed, SCOPUS, and CINAHL were searched to assess articles published in English from 2010 to 2021 globally. Qualitative studies that reported on experiences of people wearing removable dentures were included. A total of ten studies were included. People who wear dentures expressed diversified experiences (both negative and positive), including physical, social, psychological processes, and affective responses. Furthermore, experiences were related to emotions, maintenance of dentures, hygiene, access to care, and cost. Those wearing implant retained dentures reported more positive experiences than those who wear conventional complete dentures. Denture wearing experiences is a complex phenomenon involving the patient in wholeness including their environment. Healthcare professionals should be considering a holistic approach when providing denture rehabilitation. There is a need to further explore denture wearing experiences using qualitative approaches, as understanding of patient experiences can inform and provide clear directions on quality improvement initiatives and health-care policy development.","PeriodicalId":19616,"journal":{"name":"Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73115510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. Favia, F. Spirito, Eleonora Lo Muzio, S. Capodiferro, A. Tempesta, L. Limongelli, L. Lo Muzio, E. Maiorano
(1) Background: The aim of this study was to compare the histopathological features of syndromic and non-syndromic odontogenic keratocysts (OKs) using conventional and Confocal Laser Scanning Microscopy (CLSM) with their biological behaviour. (2) Methods: Data from the medical records of 113 patients with histological diagnosis of (single and/or multiple) OKs were collected. Globally, 213 OKs (120 syndromic and 93 sporadic) were retrieved, and their histological slides were re-evaluated with conventional H&E staining and with autofluorescence on the same slides using CLSM (Nikon Eclipse E600 microscope). (3) Results: Syndromic OKs showed more satellite cysts than sporadic cases, as well as a basophilic layer in the basement membrane, which was absent in sporadic OKs; both were highlighted with CLSM. The basement membrane in syndromic OKs appeared amorphous and fragile, thus possibly being responsible for the epithelial detachment and collapse, with scalloped features. Furthermore, the basal epithelial layers in such cases also showed increased cellularity and proliferative activity. All these histological features may possibly justify their higher tendency to recur. (4) Conclusions: CLSM is useful advanced technology that could help to quickly and easily discriminate between syndromic and non-syndromic OKs and to more accurately predict their biological behaviour in order to set fitter clinico-radiological follow-ups for individual patients.
{"title":"Histopathological Comparative Analysis between Syndromic and Non-Syndromic Odontogenic Keratocysts: A Retrospective Study","authors":"G. Favia, F. Spirito, Eleonora Lo Muzio, S. Capodiferro, A. Tempesta, L. Limongelli, L. Lo Muzio, E. Maiorano","doi":"10.3390/oral2030019","DOIUrl":"https://doi.org/10.3390/oral2030019","url":null,"abstract":"(1) Background: The aim of this study was to compare the histopathological features of syndromic and non-syndromic odontogenic keratocysts (OKs) using conventional and Confocal Laser Scanning Microscopy (CLSM) with their biological behaviour. (2) Methods: Data from the medical records of 113 patients with histological diagnosis of (single and/or multiple) OKs were collected. Globally, 213 OKs (120 syndromic and 93 sporadic) were retrieved, and their histological slides were re-evaluated with conventional H&E staining and with autofluorescence on the same slides using CLSM (Nikon Eclipse E600 microscope). (3) Results: Syndromic OKs showed more satellite cysts than sporadic cases, as well as a basophilic layer in the basement membrane, which was absent in sporadic OKs; both were highlighted with CLSM. The basement membrane in syndromic OKs appeared amorphous and fragile, thus possibly being responsible for the epithelial detachment and collapse, with scalloped features. Furthermore, the basal epithelial layers in such cases also showed increased cellularity and proliferative activity. All these histological features may possibly justify their higher tendency to recur. (4) Conclusions: CLSM is useful advanced technology that could help to quickly and easily discriminate between syndromic and non-syndromic OKs and to more accurately predict their biological behaviour in order to set fitter clinico-radiological follow-ups for individual patients.","PeriodicalId":19616,"journal":{"name":"Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90888853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The increase in aesthetic demands has increased the use of ceramic dental restorations in dentistry. Ceramic restorations are bonded to the tooth structure using adhesives. There is a lack of standard guidelines in terms of post-bleaching time intervals and bond strengths of ceramic restorations. Bleaching products have also been stated to affect the morphology of enamel. Therefore, the purpose of this systematic review is to evaluate the bond strength between ceramic and enamel and the changes in the surface roughness of enamel post teeth bleaching. An electronic search was performed in the databases PubMed, OVID MEDLINE, Scopus, and Web of Science with MESH terms: “adhesion OR bonding”, “ceramic OR ceramics OR dental porcelain”, “tooth bleaching OR teeth bleaching OR tooth whitening OR teeth whitening” and “enamel OR dental enamel OR enamels OR dental enamels”. The articles were screened, and the final selection of articles was obtained by using the inclusion and exclusion criteria. Of the 170 studies identified from the search, only 12 studies met the inclusion criteria and were selected for full-text review. A further search by hand was performed, and additional 48 studies were selected. From the 60 full-text studies, 18 studies met the inclusion criteria and were included for data extraction. The results were based on a descriptive analysis of the effect on bond strength of ceramic to enamel after a bleaching protocol and the changes in the surface roughness of enamel post bleaching protocol. In conclusion, bleaching protocols alter the surface roughness of enamel and, thus, the shear bond strength between ceramic and enamel. Bleaching treatments with a higher concentration of hydrogen peroxide reduce the bond strength between ceramic and enamel. Delaying bonding after bleaching for up to 7 days increases the bond strength between ceramic and enamel.
审美需求的增加增加了牙科陶瓷修复体的使用。陶瓷修复体使用粘合剂粘合到牙齿结构上。在漂白后的时间间隔和陶瓷修复体的结合强度方面缺乏标准的指导方针。漂白产品也会影响牙釉质的形态。因此，本系统综述的目的是评估牙齿漂白后陶瓷与牙釉质之间的结合强度和牙釉质表面粗糙度的变化。在PubMed、OVID MEDLINE、Scopus和Web of Science数据库中进行电子检索，检索词为:“粘附或粘接”、“陶瓷或陶瓷或牙瓷”、“牙齿漂白或牙齿漂白或牙齿美白或牙齿美白”和“珐琅或牙釉质或珐琅或牙釉质”。对文章进行筛选，并根据纳入标准和排除标准对文章进行最终筛选。从检索中确定的170项研究中，只有12项研究符合纳入标准，并被选中进行全文综述。进行了进一步的手工检索，并选择了另外48项研究。从60篇全文研究中，有18篇研究符合纳入标准，被纳入数据提取。结果是基于对漂白方案后陶瓷与牙釉质结合强度的影响和漂白后牙釉质表面粗糙度变化的描述性分析。总之，漂白方案改变了牙釉质的表面粗糙度，从而改变了陶瓷和牙釉质之间的剪切结合强度。用高浓度的双氧水漂白会降低陶瓷和牙釉质之间的结合强度。在漂白后延迟粘合长达7天，可以增加陶瓷和珐琅之间的粘合强度。
{"title":"Effect of Enamel Bleaching on the Bond Strength of Ceramic—A Systematic Review","authors":"T. Seto, Anastasiia Grymak, V. Mudliar, J. Choi","doi":"10.3390/oral2020018","DOIUrl":"https://doi.org/10.3390/oral2020018","url":null,"abstract":"The increase in aesthetic demands has increased the use of ceramic dental restorations in dentistry. Ceramic restorations are bonded to the tooth structure using adhesives. There is a lack of standard guidelines in terms of post-bleaching time intervals and bond strengths of ceramic restorations. Bleaching products have also been stated to affect the morphology of enamel. Therefore, the purpose of this systematic review is to evaluate the bond strength between ceramic and enamel and the changes in the surface roughness of enamel post teeth bleaching. An electronic search was performed in the databases PubMed, OVID MEDLINE, Scopus, and Web of Science with MESH terms: “adhesion OR bonding”, “ceramic OR ceramics OR dental porcelain”, “tooth bleaching OR teeth bleaching OR tooth whitening OR teeth whitening” and “enamel OR dental enamel OR enamels OR dental enamels”. The articles were screened, and the final selection of articles was obtained by using the inclusion and exclusion criteria. Of the 170 studies identified from the search, only 12 studies met the inclusion criteria and were selected for full-text review. A further search by hand was performed, and additional 48 studies were selected. From the 60 full-text studies, 18 studies met the inclusion criteria and were included for data extraction. The results were based on a descriptive analysis of the effect on bond strength of ceramic to enamel after a bleaching protocol and the changes in the surface roughness of enamel post bleaching protocol. In conclusion, bleaching protocols alter the surface roughness of enamel and, thus, the shear bond strength between ceramic and enamel. Bleaching treatments with a higher concentration of hydrogen peroxide reduce the bond strength between ceramic and enamel. Delaying bonding after bleaching for up to 7 days increases the bond strength between ceramic and enamel.","PeriodicalId":19616,"journal":{"name":"Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83841742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Giuseppe Campanella, Giulia Artuso, M. Murgia, G. Orrù, C. Casu
(1) Background: Trismus clinically manifests as a reduction of the buccal opening and restricted mouth opening due to different etiologies, but it is often associated with traumatic phenomena. Several treatments have been proposed such as physiotherapy exercises, cryotherapy, laser therapy, hyaluronic acid and platelet-rich fibrin infiltration, but the gold standard is represented by drug therapy based on corticosteroids and NSAIDs, currently the most documented in the scientific literature. Capacitive-resistive electric transfer (Cret) therapy is used to treat musculoskeletal injuries. Cret is a non-invasive electrothermal treatment classified as deep thermo-therapy. (2) Patient: We would like to document a case of particularly traumatic trismus in a 12-year-old patient, not responsive to previous pharmacological therapy and treated with a radiofrequency device called Velvet temporomandibular joint (TMJ). Five capacitive and resistive diathermy sessions with the device were performed. The first four sessions were performed every 4 days and the fifth after 5 days. (3) Result: The maximum opening of the mouth was 10 mm at the initial stage and 38 mm at the end of the six sessions. Pain regressed after the second appointment. (4) Conclusions: Clinical studies with a good number of samples need to be conducted to evaluate the effectiveness of this device which has proved to be an excellent treatment for this refractory case to conventional therapies. Finally, it may be useful to define precise and replicable protocols to make this therapy suitable for patients with TMJ disorders.
(1)背景:牙关症临床表现为由于不同病因导致的颊开口缩小和张嘴受限，但常伴有创伤性现象。已经提出了几种治疗方法，如物理治疗运动、冷冻治疗、激光治疗、透明质酸和富血小板纤维蛋白浸润，但金标准是基于皮质类固醇和非甾体抗炎药的药物治疗，目前在科学文献中记录最多。容电阻电转移(Cret)疗法用于治疗肌肉骨骼损伤。Cret是一种非侵入性的电热治疗，被归类为深度热疗法。(2)患者:我们想要记录一个12岁的特别创伤性牙锁患者，对先前的药物治疗没有反应，并使用名为天鹅绒颞下颌关节(TMJ)的射频设备进行治疗。使用该装置进行了五次电容和电阻透热治疗。前4期每4天进行一次，第5期每5天进行一次。(3)结果:口腔初始最大开口为10 mm, 6次疗程结束时最大开口为38 mm。第二次预约后疼痛消退。(4)结论:需要进行大量的临床研究来评估该装置的有效性，该装置已被证明是常规治疗难治性病例的极好治疗方法。最后，它可能是有用的定义精确和可复制的方案，使这种治疗适用于患者的颞下颌关节疾病。
{"title":"Severe Post-Traumatic Trismus Unresponsive to Drug Therapy in a 12-Year-Old Patient Treated with a Capacitive-Resistive Electrical Transfer Therapy: A Case Report","authors":"Giuseppe Campanella, Giulia Artuso, M. Murgia, G. Orrù, C. Casu","doi":"10.3390/oral2020017","DOIUrl":"https://doi.org/10.3390/oral2020017","url":null,"abstract":"(1) Background: Trismus clinically manifests as a reduction of the buccal opening and restricted mouth opening due to different etiologies, but it is often associated with traumatic phenomena. Several treatments have been proposed such as physiotherapy exercises, cryotherapy, laser therapy, hyaluronic acid and platelet-rich fibrin infiltration, but the gold standard is represented by drug therapy based on corticosteroids and NSAIDs, currently the most documented in the scientific literature. Capacitive-resistive electric transfer (Cret) therapy is used to treat musculoskeletal injuries. Cret is a non-invasive electrothermal treatment classified as deep thermo-therapy. (2) Patient: We would like to document a case of particularly traumatic trismus in a 12-year-old patient, not responsive to previous pharmacological therapy and treated with a radiofrequency device called Velvet temporomandibular joint (TMJ). Five capacitive and resistive diathermy sessions with the device were performed. The first four sessions were performed every 4 days and the fifth after 5 days. (3) Result: The maximum opening of the mouth was 10 mm at the initial stage and 38 mm at the end of the six sessions. Pain regressed after the second appointment. (4) Conclusions: Clinical studies with a good number of samples need to be conducted to evaluate the effectiveness of this device which has proved to be an excellent treatment for this refractory case to conventional therapies. Finally, it may be useful to define precise and replicable protocols to make this therapy suitable for patients with TMJ disorders.","PeriodicalId":19616,"journal":{"name":"Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83850180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: To review dento-facial evolution based on fossil data, comparative anatomy, developmental biology and genetics. Modern human evolution reveals profound insight into the technical and biological challenges faced by clinicians in daily practice of dentistry. Materials and Methods: An analysis and review of the literature is presented to further explain the evolutionary forces that have shaped hominins. Results: Modern human evolutionary morphological and biological adaptations allowed improvement of cognitive ability, facial expression, smile and language. However, the increased cranial capacity correlates inversely with a decrease in size of the maxillary and mandibular bones, weakening of the muscles and facial shortening, contributing to dento-facial complications. Moreover, the distinctive differences in origin and development of the dento-facial components have further contributed to these maladies. In addition, human lifestyle transition from nomadic to sedentary increased the incidence of oral diseases. Conclusions: Knowledge of human evolutionary patterns can improve the quality of response by clinicians to biological challenges. The limitations in current treatment modalities can be explained, in part, due to the complexity of the life forms that resulted from evolution. Although there are no rules to predict how evolutionary forces will shape modern humans, the evolution of the dento-facial complex reveals profound insight into our connection to other forms of life and nature.
{"title":"Human Dento-Facial Evolution: Cranial Capacity, Facial Expression, Language, Oral Complications and Diseases","authors":"H. Nowzari, Michael Jorgensen","doi":"10.3390/oral2020016","DOIUrl":"https://doi.org/10.3390/oral2020016","url":null,"abstract":"Objectives: To review dento-facial evolution based on fossil data, comparative anatomy, developmental biology and genetics. Modern human evolution reveals profound insight into the technical and biological challenges faced by clinicians in daily practice of dentistry. Materials and Methods: An analysis and review of the literature is presented to further explain the evolutionary forces that have shaped hominins. Results: Modern human evolutionary morphological and biological adaptations allowed improvement of cognitive ability, facial expression, smile and language. However, the increased cranial capacity correlates inversely with a decrease in size of the maxillary and mandibular bones, weakening of the muscles and facial shortening, contributing to dento-facial complications. Moreover, the distinctive differences in origin and development of the dento-facial components have further contributed to these maladies. In addition, human lifestyle transition from nomadic to sedentary increased the incidence of oral diseases. Conclusions: Knowledge of human evolutionary patterns can improve the quality of response by clinicians to biological challenges. The limitations in current treatment modalities can be explained, in part, due to the complexity of the life forms that resulted from evolution. Although there are no rules to predict how evolutionary forces will shape modern humans, the evolution of the dento-facial complex reveals profound insight into our connection to other forms of life and nature.","PeriodicalId":19616,"journal":{"name":"Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90393336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. Sapkota, E. M. Vallenari, Dhanalakshmi Tamatam, O. Schreurs, S. Pandey, T. M. Søland, D. Costea, Burcu Tokozlu, H. Åsheim
Ephrin-B1,-B2 and -B3 proteins share a high degree of sequence similarity. Investigation of these proteins as putative prognostic markers in human cancers including oral squamous cell carcinoma (OSCC) has been limited by challenges in generating specific antibodies against them. The current study examined the reactivity of a polyclonal anti-human ephrin-B2 antibody (HPA008999) against ephrin-B proteins and investigated the prognostic significance of immunoreactivity of the same antibody at different intra-tumor sites in OSCC specimens. By amino acid sequence comparison, immunocytochemistry and Western blot analysis on cell lysates and precipitates from HEK-293T cells transfected with EFNB1, EFNB2, or EFNB3 expression constructs, we demonstrated that HPA008999 reacted to all ephrin-B proteins. Using immunohistochemistry (IHC) with the HPA008999 antibody in a cohort (n = 131) of OSCC, we showed high immunoreactivity at the tumor center, but not at the tumor invading front, was significantly associated with worse 5-year overall survival probabilities. In conclusion, the HPA008999 antibody reacted to all ephrin-B proteins and the immunoreactivity at the tumor center might be useful as a prognostic marker in OSCC. These data underscore the need for the investigation of antibodies for cross-reactivity to similar protein members for obtaining reliable and meaningful results in IHC based biomarker studies.
{"title":"Investigation of Cross-Reactivity of Anti-Ephrin-B2 Antibody to Other Ephrin-B Members in an Immunohistochemical Study in a Cohort of Oral Squamous Cell Carcinoma","authors":"D. Sapkota, E. M. Vallenari, Dhanalakshmi Tamatam, O. Schreurs, S. Pandey, T. M. Søland, D. Costea, Burcu Tokozlu, H. Åsheim","doi":"10.3390/oral2020015","DOIUrl":"https://doi.org/10.3390/oral2020015","url":null,"abstract":"Ephrin-B1,-B2 and -B3 proteins share a high degree of sequence similarity. Investigation of these proteins as putative prognostic markers in human cancers including oral squamous cell carcinoma (OSCC) has been limited by challenges in generating specific antibodies against them. The current study examined the reactivity of a polyclonal anti-human ephrin-B2 antibody (HPA008999) against ephrin-B proteins and investigated the prognostic significance of immunoreactivity of the same antibody at different intra-tumor sites in OSCC specimens. By amino acid sequence comparison, immunocytochemistry and Western blot analysis on cell lysates and precipitates from HEK-293T cells transfected with EFNB1, EFNB2, or EFNB3 expression constructs, we demonstrated that HPA008999 reacted to all ephrin-B proteins. Using immunohistochemistry (IHC) with the HPA008999 antibody in a cohort (n = 131) of OSCC, we showed high immunoreactivity at the tumor center, but not at the tumor invading front, was significantly associated with worse 5-year overall survival probabilities. In conclusion, the HPA008999 antibody reacted to all ephrin-B proteins and the immunoreactivity at the tumor center might be useful as a prognostic marker in OSCC. These data underscore the need for the investigation of antibodies for cross-reactivity to similar protein members for obtaining reliable and meaningful results in IHC based biomarker studies.","PeriodicalId":19616,"journal":{"name":"Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84445013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V. Fusco, G. Campisi, P. Carcieri, F. Fagioli, O. Bertetto, M. Mignogna, A. Bedogni
On the 8th and 9th of May 2021, an online conference was organized to connect Italian physicians, dentists and oral care specialists, students, nurses, psychologists, dental hygiene experts, and other professionals to discuss controversial issues about Medication-Related Osteonecrosis of Jaw (MRONJ). The first section evaluated differences between Italian recommendations, released on 2020 by Italian Societies of Oral Pathology and Medicine (SIPMO) and Maxillofacial Surgery (SICMF), and other international practice guidelines or documents. A first round table gathered expert opinions about MRONJ definitions and staging systems. Another round table was dedicated to opinion of drug prescribers (oncologists, hematologists, rheumatologists, and other physicians treating osteoporosis). Educational sessions illustrated the main differences between previous (2013) and more recent (2020) Italian recommendations. A large space was dedicated to the presentation of scientific contributions from centers in Italy, divided in specific sessions (epidemiology; case series; special case reports; prevention experiences; MRONJ treatment). Conclusions: in an innovative web conference, talks and scientific reports underlined importance of adequate imaging study of bone in definition and staging of MRONJ cases, the role of surgery in treatment of the disease, and the value of oral hygiene in the prevention.
{"title":"ONJ (MRONJ) Update 2021—Osteonecrosis of Jaw Related to Bisphosphonates and Other Drugs—Prevention, Diagnosis, Pharmacovigilance, Treatment: A 2021 Web Event","authors":"V. Fusco, G. Campisi, P. Carcieri, F. Fagioli, O. Bertetto, M. Mignogna, A. Bedogni","doi":"10.3390/oral2020014","DOIUrl":"https://doi.org/10.3390/oral2020014","url":null,"abstract":"On the 8th and 9th of May 2021, an online conference was organized to connect Italian physicians, dentists and oral care specialists, students, nurses, psychologists, dental hygiene experts, and other professionals to discuss controversial issues about Medication-Related Osteonecrosis of Jaw (MRONJ). The first section evaluated differences between Italian recommendations, released on 2020 by Italian Societies of Oral Pathology and Medicine (SIPMO) and Maxillofacial Surgery (SICMF), and other international practice guidelines or documents. A first round table gathered expert opinions about MRONJ definitions and staging systems. Another round table was dedicated to opinion of drug prescribers (oncologists, hematologists, rheumatologists, and other physicians treating osteoporosis). Educational sessions illustrated the main differences between previous (2013) and more recent (2020) Italian recommendations. A large space was dedicated to the presentation of scientific contributions from centers in Italy, divided in specific sessions (epidemiology; case series; special case reports; prevention experiences; MRONJ treatment). Conclusions: in an innovative web conference, talks and scientific reports underlined importance of adequate imaging study of bone in definition and staging of MRONJ cases, the role of surgery in treatment of the disease, and the value of oral hygiene in the prevention.","PeriodicalId":19616,"journal":{"name":"Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics","volume":"285 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77845732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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