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Role of Nasopharyngeal Airway in Management of Craniofacial Syndrome-Associated Upper Airway Obstruction in Children. 鼻咽通气道在治疗颅面综合征相关儿童上呼吸道阻塞中的作用。
IF 2.4 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-11-06 DOI: 10.1111/ocr.12872
Samara Thambar, Matthew D Wong, Sandra Schilling, Nitin Kapur

Introduction: Upper airway obstruction (UAO) management in children, particularly those with associated anatomical mid-face structural differences, poses a significant challenge. This study describes using a nasopharyngeal airway (NPA) in managing infants with severe upper airway obstruction.

Methods: Infants discharged home from Queensland Children's Hospital with an NPA in situ for the management of upper airway obstruction were retrospectively evaluated for clinical and demographic parameters, underlying diagnoses and respiratory support, including NPA insertion details and comorbidities.

Results: Sixty-seven children (24 male) were included with a median age at NPA insertion of 24 (IQR 7-59) days and a median duration of NPA use of 229.1 (IQR 151.50-297.75) days. Fifty-two (77.6%) had Pierre Robin sequence. Other diagnoses included CHARGE syndrome, Treacher Collins syndrome, Stickler syndrome, Crouzon syndrome, Bohring-Opitz syndrome, isolated cleft palate, Beckwith-Wiedemann syndrome, Chromosome 3 deletion and VACTERL association. Four infants required tracheostomy, and no complications related to NPA use were reported. Those with oximetry and polysomnography data showed improving indices following NPA insertion [pre NPA median (IQR) SpO2: 95.9% (94.73-97.73), AHI: 51.40 (44.50-69.45), OAHI 65.9 (56.45-73.35) and TcCO2 (mmHg) 65.70 (61.95-67.30) vs. post-NPA median (IQR) SpO2: 97.1% (96.19-97.9), AHI: 12.20 (11.25-24.35), OAHI 10.20 (6.12-5.62) and TcCO2 (mmHg) 52.40 (47.90-58.40)].

Conclusion: Our findings highlight the effectiveness and safety of NPA as a noninvasive management option for severe upper airway obstruction in children, particularly in those with anatomical midface structural differences. Further research and larger studies are warranted to confirm these findings and optimise management strategies for these patients.

导言:儿童上气道阻塞(UAO)的治疗,尤其是那些伴有面中部解剖结构差异的儿童,是一项巨大的挑战。本研究介绍了使用鼻咽通气道(NPA)治疗严重上气道梗阻婴儿的方法:方法:对从昆士兰儿童医院出院回家并在原位安装了 NPA 以治疗上气道阻塞的婴儿进行了回顾性评估,包括临床和人口学参数、基础诊断和呼吸支持,包括 NPA 插入细节和合并症:共纳入 67 名儿童(24 名男性),插入 NPA 时的中位年龄为 24 天(IQR 7-59 天),使用 NPA 的中位持续时间为 229.1 天(IQR 151.50-297.75 天)。52例(77.6%)患者患有皮埃尔-罗宾序列。其他诊断包括CHARGE综合征、特雷撤-科林斯综合征、斯蒂克勒综合征、克鲁宗综合征、博林-奥皮茨综合征、孤立性腭裂、贝克维茨-韦德曼综合征、染色体3缺失和VACTERL关联。有四名婴儿需要进行气管造口术,但未报告与使用 NPA 有关的并发症。有血氧饱和度和多导睡眠监测数据的婴儿在植入 NPA 后各项指标均有所改善[NPA 前 SpO2 中位数(IQR):95.9%(94.73%)]:95.9% (94.73-97.73), AHI: 51.40 (44.50-69.45), OAHI 65.9 (56.45-73.35) and TcCO2 (mmHg) 65.70 (61.95-67.30) vs. NPA 后中位数(IQR)SpO2:97.1%(96.19-97.9)、AHI:12.20(11.25-24.35)、OAHI 10.20(6.12-5.62)和 TcCO2(mmHg)52.40(47.90-58.40)]:我们的研究结果凸显了 NPA 作为儿童严重上气道阻塞的无创治疗方案的有效性和安全性,尤其是对于那些存在解剖学中面结构差异的儿童。为了证实这些研究结果并优化这些患者的管理策略,有必要开展进一步的研究和更大规模的研究。
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引用次数: 0
Effects of Active Presurgical Orthopaedics Appliances in Infants With Complete Unilateral Cleft Lip and 'T-Shaped' Alveolus: A Preliminary Study. 活性术前矫形器对完全性单侧唇裂和 "T形 "齿槽婴儿的影响:初步研究。
IF 2.4 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-10-30 DOI: 10.1111/ocr.12870
Trang Thi-Huyen Nguyen, Thuy-Trang Thi Ho, Dau Van Nguyen, Nam Cong-Nhat Huynh

Objectives: This study aimed to assess the efficacy of active presurgical orthopaedics appliances in infants presenting with complete unilateral cleft lip and overlapped alveolus (T-shaped alveolus).

Materials and methods: A retrospective and prospective longitudinal study was performed. Infants diagnosed with complete unilateral cleft lip and overlapped alveolus, received treatment with the active presurgical orthopaedics appliances from June 2020 to June 2023, at Children's Hospital 1, Ho Chi Minh City. The treatment duration averaged 3 months. Pre- and posttreatment casts of noses and alveolus were scanned using TRIOS3 Wireless intraoral scanner (3Shape, Denmark) and analysed with Slicer 5.2.2 software. There were 16 quantitative variables. A pair t-test and Wilcoxon signed ranks were used for analysis. The statistical significance was adopted as p < 0.05.

Results: A total 40 patients (17 males, 23 females, mean age 23.85 ± 19.22 days) were evaluated. After treatment, the nostril height increased by 2.62 ± 0.22 mm and the deviation columella decreased by -23.45° ± 2.29°. There was a reduction in cleft gap (-3.77 ± 2.01 mm), and in the overlap of alveolus (-3.71 ± 1.83 mm), the growth of cleft segment increased by 2.27 ± 2.00 mm, while the rotation of the noncleft side alveolus decreased by -5.29° ± 5.31°. The changes were statistically significant (p < 0.001).

Conclusions: Active presurgical orthopaedics appliances improved the nasal deformity and overlapped alveolus morphology in infants with complete unilateral cleft lip and T-shaped alveolus.

研究目的本研究旨在评估积极的术前矫形器对患有完全性单侧唇裂和齿槽重叠(T 形齿槽)的婴儿的疗效:进行了一项回顾性和前瞻性纵向研究。从 2020 年 6 月至 2023 年 6 月,胡志明市第一儿童医院对确诊为完全性单侧唇裂和齿槽重叠的婴儿进行了积极的术前矫形器治疗。治疗时间平均为 3 个月。使用 TRIOS3 无线口内扫描仪(3Shape,丹麦)对治疗前和治疗后的鼻子和肺泡模型进行扫描,并使用 Slicer 5.2.2 软件进行分析。共有 16 个定量变量。采用配对 t 检验和 Wilcoxon 符号秩进行分析。统计显著性以 p 表示:共评估了 40 名患者(17 名男性,23 名女性,平均年龄(23.85 ± 19.22 天)。治疗后,鼻孔高度增加了(2.62±0.22)毫米,鼻翼偏斜减少了(-23.45±2.29)°。裂隙缩小(-3.77±2.01 mm),肺泡重叠(-3.71±1.83 mm),裂隙段增长(2.27±2.00 mm),非裂隙侧肺泡旋转(-5.29°±5.31°)。这些变化均有统计学意义(P 结论):积极的术前矫形器可改善完全性单侧唇裂和 T 型肺泡婴儿的鼻畸形和重叠肺泡形态。
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引用次数: 0
Efficacy of Clear Aligner Therapy for the Treatment of Anterior Open Bite in Adults: A Systematic Review and Meta-Analysis. 透明矫治器治疗成人前开放性咬合的疗效:系统回顾与元分析》。
IF 2.4 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-10-24 DOI: 10.1111/ocr.12868
Erika Correa, Dimitrios Michelogiannakis, Abdul Basir Barmak, Paul Emile Rossouw, Fawad Javed

The objective of the present systematic review and meta-analysis was to assess the effectiveness of clear aligner therapy (CAT) for the treatment of anterior open bite (AOB) in adults. The focused question was "Is CAT effective for the management of AOB in adults?". Databases were searched without time and language barriers up to and including August 2024 based on pre-specified eligibility criteria. Risk of Bias (RoB) assessment was performed using the Risk-of-Bias-In-Non-randomised-Studies-of-Intervention (ROBINS-I) tool. Meta-analyses were conducted using a random effects model (REM) for change in AOB and cephalometric measurements with an evaluation of the mean difference (MD) and/or standardised mean difference (SMD). The Grades of Recommendation, Assessment, Development and Evaluation (GRADE) tool was used to assess the quality of evidence. Publication bias was assessed using Funnel plots and Egger's regression test. There were 14 studies included in the qualitative assessment and 12 in the meta-analysis. The RoB was moderate in 13 studies and low in one. The meta-analysis showed significant AOB correction with CAT [(MD) = 2.76 mm, 95% confidence interval (CI): 2.23-3.28] due to maxillary and mandibular incisor extrusion (MD = 0.85 mm, CI: 0.43-1.26 and MD = 0.86 mm, CI: 0.29-1.44, respectively). There were no significant changes identified for maxillary and mandibular molar intrusion or changes in the mandibular plane angle (MPA). The level of confidence was high for AOB correction, incisor extrusion, and molar intrusion and low for MPA. CAT leads to a significant correction of AOB of approximately 2.76 mm, which can be mainly attributed to incisor extrusion.

本系统综述和荟萃分析旨在评估透明矫治器疗法(CAT)治疗成人前牙开合咬合(AOB)的有效性。重点问题是 "CAT 是否能有效治疗成人前牙反咬合(AOB)"。根据预先规定的资格标准,在 2024 年 8 月(含 2024 年 8 月)之前对数据库进行了无时间和语言障碍检索。使用偏倚风险-非随机干预研究(ROBINS-I)工具进行偏倚风险(RoB)评估。采用随机效应模型(REM)对AOB和头形测量值的变化进行元分析,评估平均差(MD)和/或标准化平均差(SMD)。推荐、评估、发展和评价分级(GRADE)工具用于评估证据质量。使用漏斗图和 Egger 回归检验对发表偏倚进行评估。共有 14 项研究被纳入定性评估,12 项被纳入荟萃分析。13 项研究的 RoB 值为中度,1 项研究的 RoB 值为低度。荟萃分析表明,由于上颌和下颌切牙挤压(MD = 0.85 mm,CI:0.43-1.26 和 MD = 0.86 mm,CI:0.29-1.44),CAT 对 AOB 有显著的矫正作用[(MD)= 2.76 mm,95% 置信区间(CI):2.23-3.28]。上颌和下颌臼齿内陷或下颌平面角(MPA)没有明显变化。AOB矫正、切牙挤压和臼齿内陷的置信度较高,而MPA的置信度较低。CAT 可显著矫正 AOB 约 2.76 mm,这主要归因于切牙挤压。
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引用次数: 0
The Mechanical Properties of Orthodontic Aligners of Clear Aligner After Intraoral Use in Different Time Periods. 不同时间段口内使用透明矫治器后矫治器的机械性能。
IF 2.4 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-10-23 DOI: 10.1111/ocr.12867
Kalliopi Siotou, Theofanis Chountalas, Athanasios Katsavrias, Charalampos Siotos, Konstantinos Mpalias, Dionysios Semitekolos, Constantinos Charitidis, Apostolos I Tsolakis

Objective: Although the technique of orthodontic aligners has risen in popularity, their mechanical properties have not been thoroughly investigated. The aim of this study was to evaluate the mechanical properties of the orthodontic aligners Clear Aligner after intraoral use for 7, 10 and 14 days, and to compare them with as-received aligners (0 days). It was also sought to examine the properties of the unprocessed raw material (polyethylene glycol terephthalate) used to manufacture these aligners.

Materials/methods: Thirty-two aligners by four patients were evaluated and studied at 0, 7, 10, 14 days of use. Each aligner was divided into three segments (two posterior and one anterior), which resulted in 96 samples. Also, 16 samples of unprocessed material were studied. For all samples, elastic modulus, ultimate tensile stress (UTS) and yield stress were calculated by conducting tensile testing. Additionally, material hardness was tested. The two-tailed Mann-Whitney test was performed, having set the level of significance at p = 0.05.

Results: Analysis of the measurements indicated a statistically significant decrease in elastic modulus between days 0 and 14 of use, of UTS between days 0 and 7, 7 and 10, and of yield stress between days 0 and 7. For hardness, in every period, posterior segments demonstrated significantly higher values than anterior segments. All properties of the unprocessed material were statistically significantly higher than the processed samples.

Conclusions: The unprocessed material presented significant differences in every property tested in comparison to the processed aligners. The processed material showed further deterioration over time during use. The present study provides evidence that thermoforming and ageing affect the mechanical properties of the aligners.

目的:虽然正畸矫治器的技术越来越受欢迎,但对其机械性能的研究还不够深入。本研究旨在评估口内使用 7 天、10 天和 14 天后的正畸矫治器 Clear Aligner 的机械性能,并将其与刚收到的矫治器(0 天)进行比较。此外,还试图研究用于制造这些矫治器的未加工原材料(聚对苯二甲酸乙二醇酯)的特性:对四名患者的 32 个矫治器在使用 0、7、10 和 14 天后的情况进行了评估和研究。每个矫治器分为三个部分(两个后部和一个前部),共96个样本。此外,还研究了 16 个未加工的材料样本。通过拉伸测试,计算了所有样本的弹性模量、极限拉伸应力(UTS)和屈服应力。此外,还测试了材料硬度。进行了双尾曼-惠特尼检验,显著性水平设定为 p = 0.05:测量结果分析表明,在使用的第 0 天至第 14 天期间,弹性模量有显著下降;在第 0 天至第 7 天、第 7 天和第 10 天期间,UTS 有显著下降;在第 0 天至第 7 天期间,屈服应力有显著下降。硬度方面,在每个阶段,后段的数值都明显高于前段。未加工材料的所有特性在统计学上都明显高于加工后的样品:结论:与加工过的矫治器相比,未加工过的材料在所有测试特性上都有明显差异。经过加工的材料在使用过程中会随着时间的推移而进一步退化。本研究提供的证据表明,热成型和老化会影响对齐器的机械性能。
{"title":"The Mechanical Properties of Orthodontic Aligners of Clear Aligner After Intraoral Use in Different Time Periods.","authors":"Kalliopi Siotou, Theofanis Chountalas, Athanasios Katsavrias, Charalampos Siotos, Konstantinos Mpalias, Dionysios Semitekolos, Constantinos Charitidis, Apostolos I Tsolakis","doi":"10.1111/ocr.12867","DOIUrl":"https://doi.org/10.1111/ocr.12867","url":null,"abstract":"<p><strong>Objective: </strong>Although the technique of orthodontic aligners has risen in popularity, their mechanical properties have not been thoroughly investigated. The aim of this study was to evaluate the mechanical properties of the orthodontic aligners Clear Aligner after intraoral use for 7, 10 and 14 days, and to compare them with as-received aligners (0 days). It was also sought to examine the properties of the unprocessed raw material (polyethylene glycol terephthalate) used to manufacture these aligners.</p><p><strong>Materials/methods: </strong>Thirty-two aligners by four patients were evaluated and studied at 0, 7, 10, 14 days of use. Each aligner was divided into three segments (two posterior and one anterior), which resulted in 96 samples. Also, 16 samples of unprocessed material were studied. For all samples, elastic modulus, ultimate tensile stress (UTS) and yield stress were calculated by conducting tensile testing. Additionally, material hardness was tested. The two-tailed Mann-Whitney test was performed, having set the level of significance at p = 0.05.</p><p><strong>Results: </strong>Analysis of the measurements indicated a statistically significant decrease in elastic modulus between days 0 and 14 of use, of UTS between days 0 and 7, 7 and 10, and of yield stress between days 0 and 7. For hardness, in every period, posterior segments demonstrated significantly higher values than anterior segments. All properties of the unprocessed material were statistically significantly higher than the processed samples.</p><p><strong>Conclusions: </strong>The unprocessed material presented significant differences in every property tested in comparison to the processed aligners. The processed material showed further deterioration over time during use. The present study provides evidence that thermoforming and ageing affect the mechanical properties of the aligners.</p>","PeriodicalId":19652,"journal":{"name":"Orthodontics & Craniofacial Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142505336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Practices and Perception of Paediatric Obstructive Sleep Apnea Among Orthodontists and Paediatric Dentists in Brazil: A Mixed-Methods Study. 巴西正畸医师和儿童牙医对小儿阻塞性睡眠呼吸暂停的做法和认识:混合方法研究。
IF 2.4 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-10-10 DOI: 10.1111/ocr.12866
Nathalia Carolina Fernandes Fagundes, Renata Travassos da Rosa Moreira Bastos, Arnaldo Perez, Carlos Flores-Mir, David Normando

Objectives: To explore orthodontists' (OTs) and paediatric dentists' (PDs) practices and perceptions regarding the screening and management of paediatric obstructive sleep apnea (OSA).

Methods: This explanatory sequential mixed methods design included OTs and PDs with active clinical practice in Brazil and encompassed a quantitative phase followed by a qualitative phase. In the quantitative phase, a survey assessing OSA screening and management practices was administered to OTs and PDs practicing in Brazil. Information-rich OTs and PDs were interviewed in the qualitative phase. Descriptive statistics and the chi-square test were used to analyse the survey data, while inductive content analysis was applied to the interview data. The results from both phases were integrated and reported narratively.

Results: Three hundred eighty-one OTs and PDs completed the survey, and ten of them were interviewed. Nearly half of OTs and PDs administered sleep questionnaires and demonstrated some knowledge about paediatric OSA signs and symptoms. PDs and OTs primarily offered rapid maxillary expansion and functional mandibular advancement for managing selected children with OSA, with OTs being more frequently involved in this task than PDs. OTs and PDs identified several barriers and expressed the need for support regarding access to reliable screening tools and interprofessional care.

Conclusion: Brazilian OTs and PDs were aware of the main signs and symptoms of paediatric OSA and were somewhat involved in offering oral appliance management options. To further define the role of these professionals, increasing support for dental professionals in OSA management and updating existing clinical guidelines is warranted.

目的探讨正畸医师(OTs)和儿童牙医(PDs)在筛查和管理儿童阻塞性睡眠呼吸暂停(OSA)方面的做法和看法:这种解释性顺序混合方法设计包括在巴西积极开展临床实践的口腔正畸医生和儿童牙科医生,包括定量阶段和定性阶段。在定量阶段,对在巴西执业的OT和PD进行了一项调查,评估OSA筛查和管理方法。在定性阶段,对信息丰富的职业定向治疗师和专科医师进行了访谈。调查数据采用了描述性统计和卡方检验,访谈数据则采用了归纳内容分析。对两个阶段的结果进行了整合和叙述性报告:共有 381 名职业技术人员和专业人员完成了调查,其中 10 人接受了访谈。近一半的康复治疗师和助产士进行了睡眠问卷调查,并对小儿 OSA 的体征和症状有了一定的了解。儿童保健医生和加护病房医生主要提供快速上颌扩弓术和功能性下颌前突术来治疗部分OSA患儿,其中加护病房医生比儿童保健医生更常参与这项工作。OT和PD发现了一些障碍,并表示在获得可靠的筛查工具和跨专业护理方面需要支持:结论:巴西的康复治疗师和儿童保健医生了解小儿 OSA 的主要体征和症状,并在一定程度上参与了提供口腔用具管理方案的工作。为了进一步明确这些专业人员的作用,有必要增加对牙科专业人员在 OSA 管理方面的支持,并更新现有的临床指南。
{"title":"Practices and Perception of Paediatric Obstructive Sleep Apnea Among Orthodontists and Paediatric Dentists in Brazil: A Mixed-Methods Study.","authors":"Nathalia Carolina Fernandes Fagundes, Renata Travassos da Rosa Moreira Bastos, Arnaldo Perez, Carlos Flores-Mir, David Normando","doi":"10.1111/ocr.12866","DOIUrl":"https://doi.org/10.1111/ocr.12866","url":null,"abstract":"<p><strong>Objectives: </strong>To explore orthodontists' (OTs) and paediatric dentists' (PDs) practices and perceptions regarding the screening and management of paediatric obstructive sleep apnea (OSA).</p><p><strong>Methods: </strong>This explanatory sequential mixed methods design included OTs and PDs with active clinical practice in Brazil and encompassed a quantitative phase followed by a qualitative phase. In the quantitative phase, a survey assessing OSA screening and management practices was administered to OTs and PDs practicing in Brazil. Information-rich OTs and PDs were interviewed in the qualitative phase. Descriptive statistics and the chi-square test were used to analyse the survey data, while inductive content analysis was applied to the interview data. The results from both phases were integrated and reported narratively.</p><p><strong>Results: </strong>Three hundred eighty-one OTs and PDs completed the survey, and ten of them were interviewed. Nearly half of OTs and PDs administered sleep questionnaires and demonstrated some knowledge about paediatric OSA signs and symptoms. PDs and OTs primarily offered rapid maxillary expansion and functional mandibular advancement for managing selected children with OSA, with OTs being more frequently involved in this task than PDs. OTs and PDs identified several barriers and expressed the need for support regarding access to reliable screening tools and interprofessional care.</p><p><strong>Conclusion: </strong>Brazilian OTs and PDs were aware of the main signs and symptoms of paediatric OSA and were somewhat involved in offering oral appliance management options. To further define the role of these professionals, increasing support for dental professionals in OSA management and updating existing clinical guidelines is warranted.</p>","PeriodicalId":19652,"journal":{"name":"Orthodontics & Craniofacial Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142471719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In Vitro Comparison of Direct Attachment Shape and Size on the Orthodontic Forces and Moments Generated by Thermoplastic Aligners During Expansion. 体外比较直接附着体的形状和大小对热塑性矫治器在扩张过程中产生的矫治力和力矩的影响。
IF 2.4 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-10-09 DOI: 10.1111/ocr.12865
Megann Lear, Amin Akbari, Olivia Robertson, Janine Magura, Alexandra Bojrab, George Eckert, Jie Chen, Richard Scott Conley, Hakan Turkkahraman

Objective: To evaluate the effects of varying direct attachment shape and size on the forces and moments generated by thermoplastic aligners during simulated expansion.

Materials and methods: An in vitro orthodontic force tester (OFT) was used to measure the forces and moments from a typodont where the buccal teeth were translated lingually 0.2 mm to simulate expansion. Hemi-ellipsoid and rectangular attachments with either 0.5 or 1.0 mm thickness were added on upper right first premolar (UR4), second premolar (UR5) and first molar (UR6). Analysis of variance (ANOVA) was used to determine two-way interactions among the factors on the outcomes.

Results: The interactions between group and tooth were significant for all outcomes (p < 0.001). The greatest buccal forces (Fy) were observed with 1 mm rectangular attachment on the UR4 (0.78 ± 0.29 N), with 1 mm hemi-ellipsoid attachment on UR5 (0.28 ± 0.21 N) and with 0.5 mm rectangular attachment on UR6 (1.71 ± 0.18 N). The greatest buccolingual moments (Mx) were obtained with 1 mm rectangular attachment on UR4 (5.61 ± 1.43 Nmm), without any attachments on UR5 (3.33 ± 1.73 Nmm) and with 1 mm hemi-ellipsoid attachment on UR6 (4.18 ± 4.31).

Conclusion: Direct attachment shape and size had a significant effect on the orthodontic forces and moments generated by thermoplastic aligners during simulated expansion. Although loads varied significantly by tooth morphology and its location in the arch, best forces and moments for expansion were obtained with 1 mm rectangular attachments on UR4s, 1 mm hemi-ellipsoid attachments on UR5s and 0.5 mm rectangular attachments on UR6s.

目的评估不同的直接附着体形状和大小对热塑性矫治器在模拟扩张过程中产生的力和力矩的影响:使用体外正畸力测试仪(OFT)测量类型矫正器产生的力和力矩,其中颊齿向舌侧移动 0.2 毫米以模拟扩弓。在右上第一前磨牙(UR4)、第二前磨牙(UR5)和第一磨牙(UR6)上添加了厚度为 0.5 或 1.0 毫米的半椭圆形和矩形附着体。采用方差分析(ANOVA)确定各因素对结果的双向交互作用:结果:组别与牙齿之间的交互作用对所有结果都有显著影响(p 结论:组别与牙齿之间的交互作用对所有结果都有显著影响:直接附着体的形状和大小对热塑性矫治器在模拟扩弓过程中产生的矫治力和力矩有显著影响。虽然负荷因牙齿形态及其在牙弓中的位置而有显著差异,但在 UR4 上使用 1 毫米矩形附着体、在 UR5 上使用 1 毫米半椭圆形附着体以及在 UR6 上使用 0.5 毫米矩形附着体时,获得了最佳的扩张力和力矩。
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引用次数: 0
Patient's Perspective on Miniscrews During Orthodontic Treatment-A Systematic Review With Meta-Analysis. 患者对正畸治疗过程中微型螺钉的看法--带 Meta 分析的系统性综述。
IF 2.4 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-10-08 DOI: 10.1111/ocr.12864
Francisco Vale, Raquel Travassos, Isabela Couto, Madalena Ribeiro, Filipa Marques, Francisco Caramelo, Carlos Miguel Marto, Gianrico Spagnuolo, Anabela Baptista Paula, Catarina Nunes, Inês Francisco

During orthodontic treatment, undesirable reciprocal forces are generated during tooth movement, which explains the use of anchorage strategies to minimise their harmful effects through intra and/or extraoral appliances. Miniscrews are intraoral devices used for temporary skeletal anchorage. Miniscrews are small-sized intraoral devices used for temporary skeletal anchorage and are easy to place and remove. However, some studies refer to adverse effects such as inflammation, pain, and discomfort. This systematic review aims to synthesise the available evidence on the use of miniscrews during orthodontic treatment from the patient's perspective. The literature search was conducted using various databases MedLine through PubMed, Cochrane Library, Web of Science Core Collection, and EMBASE. A search was also carried out in the grey literature. The search terms used were "Orthodontic Anchorage Procedures," "mini-implant," "Mini Dental Implant," "Miniscrew," and "microimplant." Cochrane risk of bias tools was used to assess the quality of included studies. Patients tend to overestimate the pain inherent in this procedure. The insertion of micro implants is more accepted than the tooth extraction procedure, with less postoperative pain reported. The location, surgical technique, and type of anaesthesia used in the placement of miniscrews influence levels of discomfort. Additionally, the execution of a good surgical technique and the clinician's communication skills are factors that influence patient satisfaction and positive perception. The most frequent outcome reported is pain and discomfort, which varies depending on its location (less with mini interradicular screws than with extra-alveolar screws). Most patients are satisfied or very satisfied with this application.

在正畸治疗过程中,牙齿移动时会产生不良的往复力,因此需要使用锚定策略,通过口内和/或口外装置将其有害影响降至最低。微型螺丝是用于临时骨骼固定的口内装置。微型螺钉是用于临时骨骼固定的小型口内装置,易于安装和拆除。然而,一些研究提到了不良反应,如发炎、疼痛和不适。本系统性综述旨在从患者的角度综合现有的关于在正畸治疗过程中使用微型螺丝的证据。文献检索使用的数据库包括 MedLine、PubMed、Cochrane Library、Web of Science Core Collection 和 EMBASE。此外,还对灰色文献进行了搜索。使用的检索词包括 "正畸固定程序"、"微型种植体"、"微型牙科种植体"、"微型螺钉 "和 "微型种植体"。科克伦偏倚风险工具用于评估纳入研究的质量。患者往往会高估这一过程中固有的疼痛。与拔牙相比,植入微型种植体更容易被接受,术后疼痛也更少。植入微型螺丝的位置、手术技术和麻醉类型会影响不适程度。此外,良好手术技术的实施和临床医生的沟通技巧也是影响患者满意度和积极感受的因素。最常报告的结果是疼痛和不适,疼痛和不适的程度因位置而异(微型关节间螺钉的疼痛和不适程度低于牙槽外螺钉)。大多数患者对这种应用感到满意或非常满意。
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引用次数: 0
Predicting the Risk of Maxillary Canine Impaction Based on Maxillary Measurements Using Supervised Machine Learning 利用监督式机器学习,根据上颌测量结果预测上颌犬齿嵌塞风险。
IF 2.4 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-10-04 DOI: 10.1111/ocr.12863
Cristiano Miranda de Araujo, Pedro Felipe de Jesus Freitas, Aline Xavier Ferraz, Patricia Kern Di Scala Andreis, Michelle Nascimento Meger, Flares Baratto-Filho, Cesar Augusto Rodenbusch Poletto, Erika Calvano Küchler, Elisa Souza Camargo, Angela Graciela Deliga Schroder

Objectives

To predict palatally impacted maxillary canines based on maxilla measurements through supervised machine learning techniques.

Materials and Methods

The maxilla images from 138 patients were analysed to investigate intermolar width, interpremolar width, interpterygoid width, maxillary length, maxillary width, nasal cavity width and nostril width, obtained through cone beam computed tomography scans. The predictive models were built using the following machine learning algorithms: Adaboost Classifier, Decision Tree, Gradient Boosting Classifier, K-Nearest Neighbours (KNN), Logistic Regression, Multilayer Perceptron Classifier (MLP), Random Forest Classifier and Support Vector Machine (SVM). A 5-fold cross-validation approach was employed to validate each model. Metrics such as area under the curve (AUC), accuracy, recall, precision and F1 Score were calculated for each model, and ROC curves were constructed.

Results

The predictive model included four variables (two dental and two skeletal measurements). The interpterygoid width and nostril width showed the largest effect sizes. The Gradient Boosting Classifier algorithm exhibited the best metrics, with AUC values ranging from 0.91 [CI95% = 0.74–0.98] for test data to 0.89 [CI95% = 0.86–0.94] for crossvalidation. The nostril width variable demonstrated the highest importance across all tested algorithms.

Conclusion

The use of maxillary measurements, through supervised machine learning techniques, is a promising method for predicting palatally impacted maxillary canines. Among the models evaluated, both the Gradient Boosting Classifier and the Random Forest Classifier demonstrated the best performance metrics, with accuracy and AUC values exceeding 0.8, indicating strong predictive capability.

目的通过有监督的机器学习技术,根据上颌骨测量结果预测腭侧上颌犬齿:分析 138 名患者的上颌骨图像,研究通过锥形束计算机断层扫描获得的磨间宽、磨间宽、翼间宽、上颌长度、上颌宽度、鼻腔宽度和鼻孔宽度。预测模型是使用以下机器学习算法建立的:Adaboost 分类器、决策树、梯度提升分类器、K-近邻(KNN)、逻辑回归、多层感知器分类器(MLP)、随机森林分类器和支持向量机(SVM)。每个模型都采用了 5 倍交叉验证方法进行验证。计算了每个模型的曲线下面积(AUC)、准确率、召回率、精确度和 F1 分数等指标,并构建了 ROC 曲线:预测模型包括四个变量(两个牙科测量值和两个骨骼测量值)。结果:预测模型包括四个变量(两个牙齿测量值和两个骨骼测量值),其中翼间宽和鼻孔宽的效应大小最大。梯度提升分类器算法的指标最好,测试数据的 AUC 值为 0.91 [CI95% = 0.74-0.98],交叉验证的 AUC 值为 0.89 [CI95% = 0.86-0.94]。在所有测试算法中,鼻孔宽度变量的重要性最高:结论:通过有监督的机器学习技术使用上颌测量值是一种预测腭侧上颌犬齿的有效方法。在评估的模型中,梯度提升分类器和随机森林分类器的性能指标最好,准确率和AUC值均超过0.8,显示出很强的预测能力。
{"title":"Predicting the Risk of Maxillary Canine Impaction Based on Maxillary Measurements Using Supervised Machine Learning","authors":"Cristiano Miranda de Araujo,&nbsp;Pedro Felipe de Jesus Freitas,&nbsp;Aline Xavier Ferraz,&nbsp;Patricia Kern Di Scala Andreis,&nbsp;Michelle Nascimento Meger,&nbsp;Flares Baratto-Filho,&nbsp;Cesar Augusto Rodenbusch Poletto,&nbsp;Erika Calvano Küchler,&nbsp;Elisa Souza Camargo,&nbsp;Angela Graciela Deliga Schroder","doi":"10.1111/ocr.12863","DOIUrl":"10.1111/ocr.12863","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To predict palatally impacted maxillary canines based on maxilla measurements through supervised machine learning techniques.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>The maxilla images from 138 patients were analysed to investigate intermolar width, interpremolar width, interpterygoid width, maxillary length, maxillary width, nasal cavity width and nostril width, obtained through cone beam computed tomography scans. The predictive models were built using the following machine learning algorithms: Adaboost Classifier, Decision Tree, Gradient Boosting Classifier, K-Nearest Neighbours (KNN), Logistic Regression, Multilayer Perceptron Classifier (MLP), Random Forest Classifier and Support Vector Machine (SVM). A 5-fold cross-validation approach was employed to validate each model. Metrics such as area under the curve (AUC), accuracy, recall, precision and F1 Score were calculated for each model, and ROC curves were constructed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The predictive model included four variables (two dental and two skeletal measurements). The interpterygoid width and nostril width showed the largest effect sizes. The Gradient Boosting Classifier algorithm exhibited the best metrics, with AUC values ranging from 0.91 [CI95% = 0.74–0.98] for test data to 0.89 [CI95% = 0.86–0.94] for crossvalidation. The nostril width variable demonstrated the highest importance across all tested algorithms.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The use of maxillary measurements, through supervised machine learning techniques, is a promising method for predicting palatally impacted maxillary canines. Among the models evaluated, both the Gradient Boosting Classifier and the Random Forest Classifier demonstrated the best performance metrics, with accuracy and AUC values exceeding 0.8, indicating strong predictive capability.</p>\u0000 </section>\u0000 </div>","PeriodicalId":19652,"journal":{"name":"Orthodontics & Craniofacial Research","volume":"28 1","pages":"207-215"},"PeriodicalIF":2.4,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142372483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Piezo1 Promotes Osteogenesis Through CaMKII Signalling in a Rat Maxillary Expansion Model 在大鼠上颌骨扩张模型中,Piezo1 通过 CaMKII 信号促进骨生成
IF 2.4 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-10-01 DOI: 10.1111/ocr.12862
Zhengquan He, Yugui Du, Chuhan Peng, Bowen Xu, Jiayue Tang, Runxuan Liu, Kai Yang

Objectives

Rapid maxillary expansion (RME) is a widely used technique to treat maxillary transverse deficiency. Piezo1 is a cation channel that is activated by mechanical force and regulates bone formation. This study aims to elucidate the role of Piezo1 in bone remodelling during the RME process.

Materials and Methods

In this study, the periosteal-derived stem cells (PDSCs) were cultured and stretched by the Flexcell system. The effects of Piezo1 on osteogenesis were assessed via RNA sequencing, real-time quantitative PCR, and western blot analyses. Moreover, for in vivo analyses, the rat RME model was established. The function of Piezo1 in mid-palatal suture bone remodelling was evaluated using micro-CT, haematoxylin–eosin (HE) staining, and immunohistochemistry analyses.

Results

It was revealed that under tension force, the osteogenic factors (Runt-related transcription factor 2, Osterix, and Alkaline Phosphatase) and Ca2+/calmodulin -dependent protein kinase (CaMKII) were significantly enhanced in PDSCs over time. Furthermore, these were also upregulated in the RME model with the expansion of the mid-palatal suture. However, Piezo1 inhibition by Grammostola spatulata mechanotoxin 4 downregulated the levels of these factors in the RME model.

Conclusions

This study indicated that Piezo1 is associated with the osteogenesis of PDSCs and bone remodelling in the RME process. CaMKII might also participate in this process.

目的:上颌骨快速扩张术(RME)是一种广泛应用于治疗上颌骨横向缺损的技术。Piezo1 是一种阳离子通道,可被机械力激活并调节骨形成。本研究旨在阐明 Piezo1 在 RME 过程中骨重塑中的作用:本研究采用 Flexcell 系统培养和拉伸骨膜源性干细胞(PDSCs)。通过RNA测序、实时定量PCR和Western印迹分析评估了Piezo1对成骨的影响。此外,为了进行体内分析,还建立了大鼠 RME 模型。通过显微 CT、血栓素-伊红(HE)染色和免疫组化分析评估了 Piezo1 在腭中缝骨重塑中的功能:结果:研究发现,在张力作用下,PDSCs 中的成骨因子(Runt 相关转录因子 2、Osterix 和碱性磷酸酶)和 Ca2+/calmodulin 依赖性蛋白激酶(CaMKII)随着时间的推移显著增强。此外,在 RME 模型中,随着腭中缝的扩张,这些酶也会上调。然而,在 RME 模型中,用 Grammostola spatulata mechanotoxin 4 抑制 Piezo1 会降低这些因子的水平:本研究表明,Piezo1与PDSCs的成骨和RME过程中的骨重塑有关。CaMKII也可能参与了这一过程。
{"title":"Piezo1 Promotes Osteogenesis Through CaMKII Signalling in a Rat Maxillary Expansion Model","authors":"Zhengquan He,&nbsp;Yugui Du,&nbsp;Chuhan Peng,&nbsp;Bowen Xu,&nbsp;Jiayue Tang,&nbsp;Runxuan Liu,&nbsp;Kai Yang","doi":"10.1111/ocr.12862","DOIUrl":"10.1111/ocr.12862","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Rapid maxillary expansion (RME) is a widely used technique to treat maxillary transverse deficiency. Piezo1 is a cation channel that is activated by mechanical force and regulates bone formation. This study aims to elucidate the role of Piezo1 in bone remodelling during the RME process.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>In this study, the periosteal-derived stem cells (PDSCs) were cultured and stretched by the Flexcell system. The effects of Piezo1 on osteogenesis were assessed via RNA sequencing, real-time quantitative PCR, and western blot analyses. Moreover, for in vivo analyses, the rat RME model was established. The function of Piezo1 in mid-palatal suture bone remodelling was evaluated using micro-CT, haematoxylin–eosin (HE) staining, and immunohistochemistry analyses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>It was revealed that under tension force, the osteogenic factors (Runt-related transcription factor 2, Osterix, and Alkaline Phosphatase) and Ca<sup>2+</sup>/calmodulin -dependent protein kinase (CaMKII) were significantly enhanced in PDSCs over time. Furthermore, these were also upregulated in the RME model with the expansion of the mid-palatal suture. However, Piezo1 inhibition by Grammostola spatulata mechanotoxin 4 downregulated the levels of these factors in the RME model.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study indicated that Piezo1 is associated with the osteogenesis of PDSCs and bone remodelling in the RME process. CaMKII might also participate in this process.</p>\u0000 </section>\u0000 </div>","PeriodicalId":19652,"journal":{"name":"Orthodontics & Craniofacial Research","volume":"28 1","pages":"196-206"},"PeriodicalIF":2.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142351422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Surgical and Camouflage Orthodontic Treatment of Anterior Open Bite: Comparison of Profile Attractiveness 外科手术和遮盖式正畸治疗前牙开合咬合:外形吸引力比较。
IF 2.4 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-09-30 DOI: 10.1111/ocr.12861
C. Q. Nogueira, P. Cotrin, D. S. Freitas, J. E. Prado de Souza, F. P. Valarelli, K. M. S. Freitas, M. R. de Freitas

Objective

To evaluate the profile's attractiveness between the different protocols for treating the anterior open bite.

Methods

The sample comprised 39 patients with anterior open bite treated with or without extractions, divided into two groups: The surgical group (G1) comprised 21 subjects (10 males, 11 females) with a mean initial age of 21.86 years (SD = 5.09), treated with fixed orthodontic appliance followed by orthognathic surgery, for a total mean period of 2.53 years (SD = 0.61). The mean overbite was −5.01 mm (SD = 2.50); The camouflaged group (G2) comprised 18 subjects (9 males, 9 females), with a mean initial age of 20.47 years (SD = 4.19), treated only with fixed orthodontic appliance, for a total mean period of 2.56 years (SD = 0.94). The mean overbite was −4.28 mm (SD = 1.15). Lateral photographs from pretreatment and posttreatment were used. These photographs were evaluated by 46 laypeople and 67 dentists, who rated the attractiveness of each profile from 0 (most unattractive profile) to 10 (most attractive profile). Intergroup comparisons were performed with independent t-tests.

Results

Both groups presented improvement in the profile attractiveness with treatment (p < 0.001). Before treatment, the profile of the surgical group was significantly less attractive than the profile of the camouflaged group (p < 0.001). The surgical presented a more attractive profile at the final stage than the camouflaged group (p < 0.001). The surgical group showed a greater improvement in profile attractiveness with treatment than the camouflaged group (p < 0.001).

Conclusion

In the final stage, the surgical presented a more attractive and greater improvement in profile attractiveness than the camouflaged group. The laypeople and dentists judged similarly the initial profile attractiveness.

目的评估不同前牙开合咬合治疗方案的外形吸引力:样本包括39名接受或未接受拔牙治疗的前牙开合咬合患者,分为两组:手术组(G1)包括 21 名受试者(10 名男性,11 名女性),初始平均年龄为 21.86 岁(SD = 5.09),先接受固定矫治器治疗,然后接受正颌手术治疗,平均治疗时间为 2.53 年(SD = 0.61)。伪装组(G2)有 18 名受试者(9 男 9 女),初始平均年龄为 20.47 岁(SD = 4.19),仅使用固定矫治器进行治疗,平均治疗时间为 2.56 年(SD = 0.94)。平均咬合过度为-4.28毫米(标准差=1.15)。使用了治疗前和治疗后的侧位照片。这些照片由 46 名非专业人士和 67 名牙医进行评估,他们对每个侧面的吸引力进行评分,从 0 分(最无吸引力的侧面)到 10 分(最有吸引力的侧面)不等。组间比较采用独立 t 检验:结果:两组患者在接受治疗后,外形吸引力都有所改善(p 结论:两组患者的外形吸引力都有所改善:在最后阶段,手术组比伪装组更具吸引力,外形吸引力的改善幅度也更大。非专业人士和牙医对初始轮廓吸引力的判断相似。
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引用次数: 0
期刊
Orthodontics & Craniofacial Research
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