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Genome scan reveals several loci associated with torus palatinus 基因组扫描揭示了与腭弓有关的几个基因位点
IF 3.1 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-09-18 DOI: 10.1111/ocr.12857
Myoung Keun Lee, Ahmed M. El Sergani, Noah Herrick, Rebecca M. Green, Carmencita Padilla, Carmen J. Buxó, Ross E. Long, Consuelo Valencia‐Ramirez, Claudia P. Restrepo Muñeton, Lina M. Moreno Uribe, Wasiu L. Adeyemo, Azeez Butali, Mary L. Marazita, John R. Shaffer, Seth M. Weinberg
ObjectiveTorus Palatinus (TP) is a common trait with an unclear aetiology. Although prior studies suggest a hereditary component, the genetic factors that influence TP risk remain unknown. The purpose of this study is to identify genetic variants associated with TP.Materials and MethodsWe assessed the TP status of 829 individuals from various ancestral backgrounds using 3D palate scans. We then carried out a genome‐wide association study (GWAS) to identify common variants associated with TP. We also performed gene‐based tests across the exome to investigate the role of low‐frequency coding variants.ResultsOur GWAS did not identify any genome‐wide significant signals but identified suggestive associations including hits on chromosomes 2, 5 and 17 with p‐values less than 5 × 10−6. Candidate genes at these suggestive loci have been implicated in normal‐range craniofacial features, syndromes with facial and oral malformations, and bone density. We did not find evidence that low‐frequency coding variants influence TP risk. In addition, we failed to replicate associations identified in prior genetic studies of TP.ConclusionThese findings suggest that multiple genes likely influence the development of TP. Independent replication will be required to confirm our suggestive associations.
目的腭裂(TP)是一种病因不明的常见特征。尽管先前的研究表明这与遗传有关,但影响腭裂风险的遗传因素仍然未知。本研究的目的是确定与腭裂相关的遗传变异。材料与方法我们利用三维腭部扫描评估了来自不同祖先背景的 829 人的腭裂状况。然后,我们开展了一项全基因组关联研究(GWAS),以确定与 TP 相关的常见变异。我们还在整个外显子组中进行了基于基因的测试,以研究低频编码变异的作用。结果我们的全基因组关联研究没有发现任何全基因组显著信号,但发现了一些提示性关联,包括 2 号、5 号和 17 号染色体上 p 值小于 5 × 10-6 的变异。这些提示性位点上的候选基因与正常范围的颅面特征、面部和口腔畸形综合征以及骨密度有关。我们没有发现低频编码变异影响 TP 风险的证据。此外,我们也未能复制之前的 TP 遗传研究中发现的关联。要证实我们的提示性关联,还需要独立的重复研究。
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引用次数: 0
Correlation analysis of airway space and condylar morphology in bilateral idiopathic condylar resorption patients 双侧特发性髁突吸收患者气道空间与髁突形态的相关性分析
IF 3.1 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-09-15 DOI: 10.1111/ocr.12855
Yanfang Yu, Xueyan Xia, Lehan Xu, Xiaoyan Chen, Ningning Zhang, Mengjie Wu
To evaluate the airway space in bilateral idiopathic condylar resorption (ICR) patients and analyse the correlation between the morphological characteristics of the condyles and airway parameters. In all, 35 female patients with bilateral ICR (mean age: 21.6 years) and 35 age‐matched female controls (mean age: 21.3 years) were included. Airway parameters were measured using CBCT. Independent T‐tests were used to analyse the differences between the bilateral ICR group and the control group, and then the correlation between airway parameters and condylar parameters was detected using Pearson correlation analysis. p < .05 was considered statistically significant. Patients with bilateral ICR showed a significant decrease in airway volume, minimum axial area and sagittal sectional area (p < .05). The bilateral condylar axial angle positively correlated with airway volume and sagittal sectional area (p < .05). In contrast, the bilateral condylar neck angle negatively correlated with sagittal sectional area (p < .05). None of the condylar parameters showed a correlation with minimum axial area of the airway in the bilateral ICR group (p > .05). Bilateral ICR significantly affects patients' airway space. The condylar axial angle and neck angle correlate with airway parameters.
目的:评估双侧特发性髁突吸收(ICR)患者的气道空间,并分析髁突形态特征与气道参数之间的相关性。共纳入 35 名双侧特发性髁状突吸收(ICR)女性患者(平均年龄:21.6 岁)和 35 名年龄匹配的女性对照组患者(平均年龄:21.3 岁)。气道参数使用 CBCT 测量。使用独立 T 检验分析双侧 ICR 组与对照组之间的差异,然后使用皮尔逊相关分析检测气道参数与髁突参数之间的相关性。双侧 ICR 患者的气道容积、最小轴向面积和矢状切面面积均显著减少(p < .05)。双侧髁状突轴向角度与气道容积和矢状切面面积呈正相关(p <.05)。相反,双侧髁状突颈部角度与矢状切面面积呈负相关(p < .05)。在双侧 ICR 组中,没有一个髁状突参数与气道最小轴向面积相关(p >.05)。双侧 ICR 明显影响患者的气道空间。髁状突轴向角度和颈部角度与气道参数相关。
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引用次数: 0
Variation of chin morphology and mandibular incisor length in different facial divergence patterns: New insights from CBCT records 不同面部分化模式下下巴形态和下颌门齿长度的变化:来自 CBCT 记录的新见解
IF 3.1 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-09-11 DOI: 10.1111/ocr.12856
Joseph G. Ghafari, Eliane G. Ziade, Ammar Kassab, Maria Saadeh, Anthony T. Macari
AimEvaluate constitutional differences in chin morphology and volume, and mandibular tooth size, between different facial divergence patterns.Materials and MethodsThe sample consisted of 284 pretreatment cone beam computed tomography (CBCT) images of growing and non‐growing patients who were stratified into 4 groups based on mandibular plane inclination to cranial base (SN) angle. Linear and angular measurements were made on the lateral CBCT images: mandibular lateral incisor crown (I‐C) total (I‐A) lengths, the distances between point D (centre of symphysis) and both incisor apex (D‐A) and menton (D‐Me) and between cemento‐enamel junction and menton (CEJ‐Me); chin width at the level of the central incisor apex (CWA) and point D (CWD); and the angles of the anterior and posterior symphyseal slopes. The volume of the symphysis was measured using a specialized 3D imaging software. Group differences and associations between parameters were gauged through the three‐way ANOVA analysis.ResultsI‐C, I‐A, D‐A, D‐Me and CEJ‐Me were greater in the hyperdivergent group (p < .001). CWA and CWD were wider in the hypodivergent group (p = .003). Volume of the chin and inter‐slope angles were similar in all groups (p > .05). The anterior slope angle decreased with hyperdivegence (p < .005) in opposite pattern to the posterior slope angle (p < .005).ConclusionsShape differences in mandibular symphysis were observed between opposite divergence patterns. Mandibular incisors were longer with hyperdivergence and shorter with hypodivergence. However, chin volumes were similar across divergence groups. These findings underline the role of genetic and environmental factors that impact facial growth.
材料和方法样本包括 284 张生长期和非生长期患者的锥形束计算机断层扫描 (CBCT) 图像,这些患者根据下颌平面倾斜度与颅底 (SN) 角度被分为 4 组。在 CBCT 侧边图像上进行了线性和角度测量:下颌侧切牙牙冠(I-C)总长度(I-A)、D 点(牙合中心)与切牙顶点(D-A)和牙弓(D-Me)之间的距离以及牙本质-釉质交界处与牙弓(CEJ-Me)之间的距离;中切牙顶点(CWA)和 D 点(CWD)水平的颏宽;以及前后牙合斜坡的角度。使用专门的三维成像软件测量了干骺端的体积。结果I-C、I-A、D-A、D-Me和CEJ-Me在超发散组更大(p <.001)。低发散组的 CWA 和 CWD 更宽(p = .003)。所有组的颏部体积和斜坡间角相似(p > .05)。结论在不同的发散模式之间观察到下颌骨干骺端的形状差异。下颌切牙在高分异时较长,在低分异时较短。然而,各分化组的颏部体积相似。这些发现强调了遗传和环境因素对面部生长的影响。
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引用次数: 0
3D-printed zirconia orthodontic brackets: Effect of printing method on dimensional accuracy 三维打印氧化锆正畸托槽:打印方法对尺寸精度的影响
IF 2.4 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-08-21 DOI: 10.1111/ocr.12847
Zhi Tang, Jingtao Dai, Anlan Yu, Ping Li, Chufeng Liu, Xiaoqing Shen

Objectives

This study investigated the effect of additive manufacturing (AM) methods on the slot height dimensions and accuracy of 3D-printed orthodontic brackets.

Methods

A 3D model of a standard Mclaughlin Bennett Trevisi bracket was used as a reference to print the ceramic bracket in a 90° orientation using two representative AM methods: digital light processing (DLP) and material jetting (MJ). The dimensional accuracy and slot heights were determined using a scanning electron microscope and an optical scanner. Also, all specimens were analysed using the Geomagic Control X 3D inspection software. The root mean square (RMS) values were used for trueness and precision assessment. Statistical analyses were performed using an independent sample t-test.

Results

Slot height dimensions, trueness RMS, and precision RMS were statistically affected by different AM methods (p < .01). There was a significant difference between the different printing methods, with DLP meeting the tolerance requirements (mean slot height = 0.557 ± 0.018 mm) and MJ being slightly below them (mean slot height = 0.544 ± 0.021 mm). However, MJ significantly outperformed DLP in terms of accuracy. Among the two printing methods, MJ was associated with higher trueness (RMS = 0.025 ± 0.004 mm) and precision (RMS = 0.038 ± 0.005 mm).

Conclusions

Both tested AM methods yielded clinically acceptable outcomes, with the RMS range set to ±100 μm and the slot height tolerance established at 0.549–0.569 mm. The MJ technology achieved the highest accuracy.

目的:本研究探讨了增材制造(AM)方法对 3D 打印正畸托槽槽高尺寸和精度的影响:本研究调查了增材制造(AM)方法对三维打印正畸托槽槽高尺寸和精度的影响:以标准 Mclaughlin Bennett Trevisi 托槽的三维模型为参考,使用两种具有代表性的 AM 方法:数字光处理 (DLP) 和材料喷射 (MJ) 以 90° 方向打印陶瓷托槽。使用扫描电子显微镜和光学扫描仪确定了尺寸精度和槽高度。此外,还使用 Geomagic Control X 3D 检测软件对所有试样进行了分析。均方根(RMS)值用于真实度和精度评估。统计分析采用独立样本 t 检验:结果:槽高度尺寸、真实度均方根和精度均方根受不同 AM 方法的统计影响(p 结论:两种测试 AM 方法都能获得临床意义上的槽高度尺寸、真实度均方根和精度均方根:所测试的两种 AM 方法都获得了临床上可接受的结果,均方根范围设定为 ±100 μm,槽高度公差设定为 0.549-0.569 mm。MJ 技术的精确度最高。
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引用次数: 0
Accuracy of clear aligners in the orthodontic rotational movement using different attachment configurations 使用不同附着结构的透明矫治器在正畸旋转运动中的准确性。
IF 2.4 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-08-19 DOI: 10.1111/ocr.12846
Gianluigi Fiorillo, Alessandra Campobasso, Silvia Croce, Umar Hussain, Giovanni Battista, Eleonora Lo Muzio, Gualtiero Mandelli, Alessandro Ambrosi, Giorgio Gastaldi

Objective

To evaluate the accuracy of dental rotational movements using clear aligners with different attachment configurations.

Materials and Methods

This retrospective study analysed 212 teeth from 89 patients undergoing Invisalign treatment. Digital models were analysed after the virtual treatment plan (ST1) and after the first treatment phase (ET1) to evaluate the effective clinical rotational movement. The rotational movements of incisors, canines, and bicuspids were measured using data from the Clincheck Movements Table. ST1 and ET1 were compared to determine the actual rotational movement achieved (ST1-ET1). The presence or absence of attachments (rectangular or optimized) on teeth was analysed. The accuracy of rotational movements among attachment types was compared using the Kruskal-Wallis test. Multiple linear regressions were conducted with accuracy as the dependent variable and tooth type, gender, and age as predictors.

Results

Optimized attachments had the highest median accuracy (70%), followed by rectangular (65%), and without attachment (63%), with no significant differences (p = .5). There were no significant differences across age groups, genders, or tooth types. Baseline accuracy was 68.62% (95% CI: 56.03–81.20, p < .001). Age was a significant predictor (estimate = −0.30, 95% CI: −0.58 – −0.03, p = .032), indicating decreased accuracy with increasing age. The model's R2 was 0.046, with an adjusted R2 of 0.003, indicating minimal variance explained.

Conclusion

The addition of attachment configurations to clear aligners improves rotational accuracy, but not significantly. Further advancements in these configurations are needed to enhance the performance of the aligners.

目的: 评估使用不同附着结构的透明矫治器进行牙齿旋转运动的准确性:评估使用不同附着结构的透明矫治器进行牙齿旋转运动的准确性:这项回顾性研究分析了接受隐适美治疗的 89 名患者的 212 颗牙齿。在虚拟治疗计划(ST1)和第一个治疗阶段(ET1)之后,对数字模型进行了分析,以评估有效的临床旋转运动。门牙、犬齿和双尖牙的旋转移动是通过 Clincheck 移动表中的数据进行测量的。将 ST1 和 ET1 进行比较,以确定实际达到的旋转运动(ST1-ET1)。对牙齿上有无附着物(矩形或优化)进行分析。使用 Kruskal-Wallis 检验比较了不同附着类型的旋转运动准确性。以准确性为因变量,以牙齿类型、性别和年龄为预测因素,进行了多元线性回归:结果:优化附着体的中位准确率最高(70%),其次是矩形附着体(65%)和无附着体(63%),三者无显著差异(p = .5)。不同年龄组、性别或牙齿类型之间没有明显差异。基线准确率为 68.62%(95% CI:56.03-81.20,p 2 为 0.046,调整后的 R2 为 0.003,表明所解释的变异最小:结论:在透明矫治器上增加附着配置可以提高旋转的准确性,但效果并不显著。需要进一步改进这些配置,以提高矫治器的性能。
{"title":"Accuracy of clear aligners in the orthodontic rotational movement using different attachment configurations","authors":"Gianluigi Fiorillo,&nbsp;Alessandra Campobasso,&nbsp;Silvia Croce,&nbsp;Umar Hussain,&nbsp;Giovanni Battista,&nbsp;Eleonora Lo Muzio,&nbsp;Gualtiero Mandelli,&nbsp;Alessandro Ambrosi,&nbsp;Giorgio Gastaldi","doi":"10.1111/ocr.12846","DOIUrl":"10.1111/ocr.12846","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To evaluate the accuracy of dental rotational movements using clear aligners with different attachment configurations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>This retrospective study analysed 212 teeth from 89 patients undergoing Invisalign treatment. Digital models were analysed after the virtual treatment plan (ST1) and after the first treatment phase (ET1) to evaluate the effective clinical rotational movement. The rotational movements of incisors, canines, and bicuspids were measured using data from the Clincheck Movements Table. ST1 and ET1 were compared to determine the actual rotational movement achieved (ST1-ET1). The presence or absence of attachments (rectangular or optimized) on teeth was analysed. The accuracy of rotational movements among attachment types was compared using the Kruskal-Wallis test. Multiple linear regressions were conducted with accuracy as the dependent variable and tooth type, gender, and age as predictors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Optimized attachments had the highest median accuracy (70%), followed by rectangular (65%), and without attachment (63%), with no significant differences (<i>p</i> = .5). There were no significant differences across age groups, genders, or tooth types. Baseline accuracy was 68.62% (95% CI: 56.03–81.20, <i>p</i> &lt; .001). Age was a significant predictor (estimate = −0.30, 95% CI: −0.58 – −0.03, <i>p</i> = .032), indicating decreased accuracy with increasing age. The model's <i>R</i><sup>2</sup> was 0.046, with an adjusted <i>R</i><sup>2</sup> of 0.003, indicating minimal variance explained.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The addition of attachment configurations to clear aligners improves rotational accuracy, but not significantly. Further advancements in these configurations are needed to enhance the performance of the aligners.</p>\u0000 </section>\u0000 </div>","PeriodicalId":19652,"journal":{"name":"Orthodontics & Craniofacial Research","volume":"27 6","pages":"996-1003"},"PeriodicalIF":2.4,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ocr.12846","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142000498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How accurate is predicted root movement achieved in four first-premolar extraction cases with Invisalign? 在四个第一前磨牙拔除病例中,使用隐适美矫正器预测牙根移动的准确性如何?
IF 2.4 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-08-13 DOI: 10.1111/ocr.12842
Fanfan Dai, Yanhui Sang, Jingjing Zeng, Hongjian Wang, Yichun Pan, Jianhui Zhao, Tianmin Xu, Guang Shu

Objectives

This study aims to compare the achieved and predicted root movements in adults after four first-premolar extractions and Invisalign treatment.

Materials and Methods

Thirty-three consecutive adults (22 Class I, 9 Cusp-to-cusp Class II and 2 Cusp-to-cusp Class III) from a single clinical division who completed the first series of aligners after premolar extractions were included in this retrospective study. A pretreatment cone-beam computed tomography model was registered onto the pretreatment surface-scanned dental model (SSDM) to locate the pretreatment root apices of the whole dentition. These were copied and transferred to the predicted and achieved post-treatment SSDMs to acquire the locations of the predicted and achieved post-treatment root apices. The differences between predicted and achieved root movements (DPARMs) were tested using the paired t-test or Wilcoxon signed rank test.

Results

In the anteroposterior direction, posterior root movements of maxillary and mandibular anterior teeth were poorly achieved (3.24–5.74 mm DPARMs, p < .05). In the vertical direction, roots of maxillary anterior teeth achieved greater intrusion (0.70–0.93 mm DPARMs, p < .05), while those of mandibular incisors achieved less intrusion (0.57–0.65 mm DPARMs, p < .05) than predicted. In the mediolateral direction, lateral incisor roots did not move distally (−0.65 to −0.96 mm DPARMs, p < .05), while those of canines did not move buccally, compared with the prediction (−0.75 mm DPARMs, p < .05).

Conclusions

In the four first-premolar extraction treatments with Invisalign, root movements were not achieved as predicted, particularly for anterior teeth in the anteroposterior direction.

研究目的本研究旨在比较四次第一前磨牙拔除和隐适美治疗后成人牙根移动的实现情况和预测情况:这项回顾性研究纳入了来自一个临床科室的连续 33 名成年人(22 名 I 类、9 名 Cusp-to-cusp II 类和 2 名 Cusp-to-cusp III 类),他们在拔除前磨牙后完成了第一轮矫治。将治疗前的锥束计算机断层扫描模型登记到治疗前的表面扫描牙科模型(SSDM)上,以确定治疗前整个牙列的根尖位置。然后将其复制并转移到预测的和实现的治疗后 SSDM 上,以获得预测的和实现的治疗后根尖的位置。使用配对t检验或Wilcoxon符号秩检验对预测的牙根移动(DPARMs)和实现的牙根移动(DPARMs)之间的差异进行检验:结果:在前胸方向上,上颌和下颌前牙的牙根后移效果不佳(DPARMs 为 3.24-5.74 mm,P在使用隐适美进行的四次第一前磨牙拔除治疗中,牙根移动未达到预期效果,尤其是前牙在前胸方向的移动。
{"title":"How accurate is predicted root movement achieved in four first-premolar extraction cases with Invisalign?","authors":"Fanfan Dai,&nbsp;Yanhui Sang,&nbsp;Jingjing Zeng,&nbsp;Hongjian Wang,&nbsp;Yichun Pan,&nbsp;Jianhui Zhao,&nbsp;Tianmin Xu,&nbsp;Guang Shu","doi":"10.1111/ocr.12842","DOIUrl":"10.1111/ocr.12842","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This study aims to compare the achieved and predicted root movements in adults after four first-premolar extractions and Invisalign treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Thirty-three consecutive adults (22 Class I, 9 Cusp-to-cusp Class II and 2 Cusp-to-cusp Class III) from a single clinical division who completed the first series of aligners after premolar extractions were included in this retrospective study. A pretreatment cone-beam computed tomography model was registered onto the pretreatment surface-scanned dental model (SSDM) to locate the pretreatment root apices of the whole dentition. These were copied and transferred to the predicted and achieved post-treatment SSDMs to acquire the locations of the predicted and achieved post-treatment root apices. The differences between predicted and achieved root movements (DPARMs) were tested using the paired t-test or Wilcoxon signed rank test.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In the anteroposterior direction, posterior root movements of maxillary and mandibular anterior teeth were poorly achieved (3.24–5.74 mm DPARMs, <i>p</i> &lt; .05). In the vertical direction, roots of maxillary anterior teeth achieved greater intrusion (0.70–0.93 mm DPARMs, <i>p</i> &lt; .05), while those of mandibular incisors achieved less intrusion (0.57–0.65 mm DPARMs, <i>p</i> &lt; .05) than predicted. In the mediolateral direction, lateral incisor roots did not move distally (−0.65 to −0.96 mm DPARMs, <i>p</i> &lt; .05), while those of canines did not move buccally, compared with the prediction (−0.75 mm DPARMs, <i>p</i> &lt; .05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>In the four first-premolar extraction treatments with Invisalign, root movements were not achieved as predicted, particularly for anterior teeth in the anteroposterior direction.</p>\u0000 </section>\u0000 </div>","PeriodicalId":19652,"journal":{"name":"Orthodontics & Craniofacial Research","volume":"27 6","pages":"985-995"},"PeriodicalIF":2.4,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ocr.12842","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141976299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of isotretinoin on tooth movement, orthodontically induced and non-orthodontic root resorption: A micro-CT study 异维A酸对牙齿移动、正畸诱发和非正畸牙根吸收的影响:显微 CT 和研究。
IF 2.4 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-08-12 DOI: 10.1111/ocr.12840
Gulay Dumanli Gok, Koray Halicioglu, Ali Keles, Nejat Vakur Olgac, Damla Kayali, Ozlem Tugce Cilingir Kaya

Objectives

This study aims to investigate whether cumulative dose-dependent isotretinoin (Roaccutane®) could affect orthodontic tooth movement (OTM) and root resorption.

Materials and Methods

Ninety male Wistar Albino rats were divided into 4 groups. While, the control (SALINE), solvent (SOYBEAN) and orthodontic drug (ISOTM) groups underwent orthodontic force, the non-orthodontic drug group (ISO) did not. The rats were administrated saline, soybean oil (SBO) and isotretinoin diluted in SBO (ISOTM, ISO) for 30 days, respectively. Six rats were euthanized in each orthodontic group. Fifty grams of orthodontic force was applied to the remaining rats' first molars using the incisors as anchorage. Six more rats in each group were euthanized on the 7th, 14th and 21st days of the force application. In the ISO group, six rats were euthanized on the 37th, 44th and 51st days of administration. Six rats that were euthanized for ISOTM on the 30th day were also used for ISO to reduce the number of rats used. Micro-computed tomography (micro-CT) and histological analysis were performed.

Results

Independent of orthodontic force, isotretinoin caused root resorption in the apical region. However, there was no statistically significant influence of isotretinoin on OTM and orthodontically induced root resorption (OIRR).

Conclusions

Despite the lack of strong evidence supporting the orthodontically induced resorptive effect of isotretinoin, this study provided findings regarding the resorptive effects of isotretinoin on non-orthodontic root resorption. Therefore, the present results underscore the importance of close monitoring during orthodontic treatment to mitigate potential root resorption in patients who use isotretinoin because of acne complaints.

研究目的本研究旨在探讨累积剂量依赖性异维A酸(Roaccutane®)是否会影响正畸牙齿移动(OTM)和牙根吸收:将 90 只雄性 Wistar 白化大鼠分为 4 组。对照组(生理盐水组)、溶剂组(大豆组)和正畸药物组(ISOTM 组)接受正畸力治疗,非正畸药物组(ISO 组)不接受正畸力治疗。分别给大鼠注射生理盐水、大豆油(SBO)和稀释在 SBO 中的异维A酸(ISOTM,ISO),为期 30 天。每个正畸组有六只大鼠被安乐死。以门牙为锚,对其余大鼠的第一臼齿施加 50 克矫治力。在施力后的第 7 天、第 14 天和第 21 天,每组再有六只大鼠被安乐死。在 ISO 组中,有六只大鼠在施力的第 37、44 和 51 天被安乐死。在 ISO 组中,有六只大鼠在施用 ISOTM 的第 30 天被安乐死,以减少使用的大鼠数量。进行了显微计算机断层扫描(micro-CT)和组织学分析:与正畸力无关,异维A酸会导致根尖区牙根吸收。然而,异维A酸对OTM和正畸诱导的牙根吸收(OIRR)没有统计学意义上的显著影响:尽管缺乏有力的证据支持异维A酸具有正畸诱导的牙根吸收作用,但本研究提供了异维A酸对非正畸牙根吸收的吸收作用。因此,本研究结果强调了在正畸治疗期间进行密切监测以减轻因痤疮而使用异维A酸的患者潜在牙根吸收的重要性。
{"title":"Effects of isotretinoin on tooth movement, orthodontically induced and non-orthodontic root resorption: A micro-CT study","authors":"Gulay Dumanli Gok,&nbsp;Koray Halicioglu,&nbsp;Ali Keles,&nbsp;Nejat Vakur Olgac,&nbsp;Damla Kayali,&nbsp;Ozlem Tugce Cilingir Kaya","doi":"10.1111/ocr.12840","DOIUrl":"10.1111/ocr.12840","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This study aims to investigate whether cumulative dose-dependent isotretinoin (Roaccutane®) could affect orthodontic tooth movement (OTM) and root resorption.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Ninety male Wistar Albino rats were divided into 4 groups. While, the control (SALINE), solvent (SOYBEAN) and orthodontic drug (ISOTM) groups underwent orthodontic force, the non-orthodontic drug group (ISO) did not. The rats were administrated saline, soybean oil (SBO) and isotretinoin diluted in SBO (ISOTM, ISO) for 30 days, respectively. Six rats were euthanized in each orthodontic group. Fifty grams of orthodontic force was applied to the remaining rats' first molars using the incisors as anchorage. Six more rats in each group were euthanized on the 7th, 14th and 21st days of the force application. In the ISO group, six rats were euthanized on the 37th, 44th and 51st days of administration. Six rats that were euthanized for ISOTM on the 30th day were also used for ISO to reduce the number of rats used. Micro-computed tomography (micro-CT) and histological analysis were performed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Independent of orthodontic force, isotretinoin caused root resorption in the apical region. However, there was no statistically significant influence of isotretinoin on OTM and orthodontically induced root resorption (OIRR).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Despite the lack of strong evidence supporting the orthodontically induced resorptive effect of isotretinoin, this study provided findings regarding the resorptive effects of isotretinoin on non-orthodontic root resorption. Therefore, the present results underscore the importance of close monitoring during orthodontic treatment to mitigate potential root resorption in patients who use isotretinoin because of acne complaints.</p>\u0000 </section>\u0000 </div>","PeriodicalId":19652,"journal":{"name":"Orthodontics & Craniofacial Research","volume":"27 6","pages":"974-984"},"PeriodicalIF":2.4,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ocr.12840","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141971559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bonding positional accuracy of attachments and marginal adaptation of in-house aligners – A quality improvement laboratory study 附着体的粘接位置准确性和内部矫正器的边缘适应性--一项质量改进实验室研究。
IF 2.4 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-08-08 DOI: 10.1111/ocr.12843
Nathália Moraes Carvalho Barreto Brandão, Raiane Machado Maia, Victor de Morais Gomes, Carolina Resende, Alberto Nogueira da Gama Antunes, Bernardo Quiroga Souki

Objectives

To evaluate the 3D accuracy of attachment positioning and the adaptation of aligners to attachments using in-house templates made with either polyethylene terephthalate glycol (PETG) or ethylene-vinyl acetate (EVA) and either pressure or vacuum thermoforming machines.

Materials and Methods

Overall, 140 test specimens were resin-printed. Templates for the attachment bonding were made with 1-mm EVA or 0.5-mm PETG laminates. Orthodontic aligners were manufactured with 0.75-mm PETG. The thermoplastification process was carried out using either vacuum or pressure machines. The positional differences between the virtual and bonded attachments were assessed in the X, Y and Z coordinates. The marginal adaptation between the aligners and the attachments was measured.

Results

Minor inaccuracies in the positioning of the attachments were observed in all combinations of thermoforming machines and plastic laminates used to fabricate the templates, mainly in the superior–inferior (Z) dimension. PETG performed better than EVA in the anterior region (p < .05). No association was found between thermoplastification machines and the accuracy of the positioning of the attachments (p > .05). While small misadaptations between the aligners and the attachments were observed, the EVA templates performed better than the PETG templates.

Conclusions

The inaccuracy of the attachment positioning and the misadaptation of the aligners to the attachments were slight. The vacuum and pressure thermoplastification machines showed no difference in attachment positioning accuracy. The PETG template was better than the EVA template in the anterior region, but the EVA attachments presented a better adaptation to the aligners than the PETG attachments.

目标:评估使用聚对苯二甲酸乙二醇酯(PETG)或乙烯-醋酸乙烯酯(EVA)制作的内部模板和压力或真空热成型机进行的附着体定位的三维准确性以及对准器对附着体的适应性:共用树脂印制了 140 个测试样本。附着粘接的模板是用 1 毫米的 EVA 或 0.5 毫米的 PETG 层压板制作的。正畸矫治器用 0.75 毫米 PETG 制作。热塑过程使用真空或压力机进行。在 X、Y 和 Z 坐标上评估了虚拟附着体和粘结附着体之间的位置差异。测量了矫治器和附着体之间的边缘适应性:结果:在所有用于制作模板的热成型机和塑料层压板组合中,都观察到了附着体定位的轻微误差,主要是在上下(Z)维度上。在前部区域,PETG 的表现优于 EVA(p .05)。虽然可以观察到矫治器和附着体之间存在微小的不适应,但 EVA 模板的表现优于 PETG 模板:结论:附着体定位的不准确性和对准器与附着体的不适应性都很轻微。真空热塑机和压力热塑机在附件定位精度方面没有差异。在前牙区,PETG模板比EVA模板更好,但EVA附着体对矫治器的适应性比PETG附着体更好。
{"title":"Bonding positional accuracy of attachments and marginal adaptation of in-house aligners – A quality improvement laboratory study","authors":"Nathália Moraes Carvalho Barreto Brandão,&nbsp;Raiane Machado Maia,&nbsp;Victor de Morais Gomes,&nbsp;Carolina Resende,&nbsp;Alberto Nogueira da Gama Antunes,&nbsp;Bernardo Quiroga Souki","doi":"10.1111/ocr.12843","DOIUrl":"10.1111/ocr.12843","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To evaluate the 3D accuracy of attachment positioning and the adaptation of aligners to attachments using in-house templates made with either polyethylene terephthalate glycol (PETG) or ethylene-vinyl acetate (EVA) and either pressure or vacuum thermoforming machines.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Overall, 140 test specimens were resin-printed. Templates for the attachment bonding were made with 1-mm EVA or 0.5-mm PETG laminates. Orthodontic aligners were manufactured with 0.75-mm PETG. The thermoplastification process was carried out using either vacuum or pressure machines. The positional differences between the virtual and bonded attachments were assessed in the <i>X</i>, <i>Y</i> and <i>Z</i> coordinates. The marginal adaptation between the aligners and the attachments was measured.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Minor inaccuracies in the positioning of the attachments were observed in all combinations of thermoforming machines and plastic laminates used to fabricate the templates, mainly in the superior–inferior (<i>Z</i>) dimension. PETG performed better than EVA in the anterior region (<i>p</i> &lt; .05). No association was found between thermoplastification machines and the accuracy of the positioning of the attachments (<i>p</i> &gt; .05). While small misadaptations between the aligners and the attachments were observed, the EVA templates performed better than the PETG templates.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The inaccuracy of the attachment positioning and the misadaptation of the aligners to the attachments were slight. The vacuum and pressure thermoplastification machines showed no difference in attachment positioning accuracy. The PETG template was better than the EVA template in the anterior region, but the EVA attachments presented a better adaptation to the aligners than the PETG attachments.</p>\u0000 </section>\u0000 </div>","PeriodicalId":19652,"journal":{"name":"Orthodontics & Craniofacial Research","volume":"27 S2","pages":"120-130"},"PeriodicalIF":2.4,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141902571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In utero nicotine exposure affects murine palate development 子宫内尼古丁暴露会影响小鼠上颚的发育。
IF 2.4 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-08-02 DOI: 10.1111/ocr.12844
Heema Vyas, Amr Mohi, Mark Boyce, Emily L. Durham, James J. Cray

Objectives

Despite data linking smoking to increased risk of fetal morbidity and mortality, 11% of pregnant women continue to smoke or use alternative nicotine products. Studies confirm that nicotine exposure during pregnancy increases the incidence of birth defects; however, little research has focused on specific anatomic areas based on timing of exposure. We aim to determine critical in utero and postnatal periods of nicotine exposure that affect craniofacial development, specifically palate growth. Malformation of the palatal structures can result in numerous complications including facial growth disturbance, or impeding airway function. We hypothesized that both in utero and postnatal nicotine exposure will alter palate development.

Materials and Methods

We administered pregnant C57BL6 mice water supplemented with 100 μg/mL nicotine during early pregnancy, throughout pregnancy, during pregnancy and lactation, or lactation only. Postnatal day 15 pups underwent micro-computed tomography (μCT) analyses specific to the palate.

Results

Resultant pups revealed significant differences in body weight from lactation-only nicotine exposure, and μCT investigation revealed several dimensions affected by lactation-only nicotine exposure, including palate width, palate and cranial base lengths, and mid-palatal suture width.

Conclusions

These results demonstrate the direct effects of nicotine on the developing palate beyond simple tobacco use. Nicotine exposure through tobacco alternatives, cessation methods, and electronic nicotine delivery systems (ENDS) may disrupt normal growth and development of the palate during development and the postnatal periods of breastfeeding. Due to the recent dramatic increase in the use of ENDS, future research will focus specifically on this nicotine delivery method.

目标:尽管有数据表明吸烟会增加胎儿发病率和死亡率,但仍有 11% 的孕妇继续吸烟或使用尼古丁替代产品。研究证实,孕期接触尼古丁会增加出生缺陷的发生率;然而,很少有研究根据接触尼古丁的时间来关注特定的解剖区域。我们的目标是确定子宫内和出生后尼古丁暴露的关键时期,这些时期会影响颅面部的发育,特别是腭部的生长。腭部结构畸形可导致多种并发症,包括面部发育障碍或阻碍气道功能。我们假设,子宫内和出生后尼古丁暴露都会改变腭部发育:我们在妊娠早期、整个妊娠期、妊娠期和哺乳期或仅哺乳期给妊娠的 C57BL6 小鼠喂食添加了 100 μg/mL 尼古丁的水。出生后第15天的幼鼠接受了专门针对腭部的微型计算机断层扫描(μCT)分析:结果:幼鼠的体重与只在哺乳期接触尼古丁的幼鼠有显著差异,μCT调查显示,只在哺乳期接触尼古丁会影响幼鼠的几个维度,包括腭宽、腭和颅底长度以及腭中缝宽度:这些结果表明,尼古丁对发育中的上颚的直接影响超出了单纯的烟草使用。通过烟草替代品、戒烟方法和电子尼古丁输送系统(ENDS)接触尼古丁可能会破坏发育期和产后哺乳期腭部的正常生长和发育。由于电子尼古丁释放系统(ENDS)的使用最近急剧增加,未来的研究将特别关注这种尼古丁释放方法。
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引用次数: 0
Evaluation of palate morphology in patients treated with leaf expander and hyrax expander: A geometric morphometric analysis 评估使用叶片扩张器和hyrax扩张器治疗的患者的腭部形态:几何形态计量分析。
IF 2.4 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-08-02 DOI: 10.1111/ocr.12839
Francesca Silvestrini-Biavati, Giorgio Oliva, Luis Huanca Ghislanzoni, Elisa Ottonelli, Domenico Dalessandri, Valentina Lanteri, Alessandro Ugolini

Objective

The aim of this study was to evaluate changes in shape of the palatal vault after maxillary expansion with hyrax expander (HE) and leaf expander (LE), using 3D Geometric Morphometric Analysis.

Setting and Sample Population

Overall, 250 patients (110 M, 140 F) with maxillary transverse deficiency were selected for this study. In this study, 127 subjects were treated with HE, 123 with LE.

Materials and Methods

Digital dental models were obtained pre-treatment (T0) and after 12 months from the cementation of the device (T1) and processed by means of a digital scanner. Linear and morphometric analyses were conducted to determine the effects of each appliance on dental measurements and palatal shape, and a multiple linear regression was performed to analyse the influence of anchorage and appliance type on final shape.

Results

Morphometric analysis showed that there was a lowering of the palatal vault in the HE group, while in the LE group it remained unchanged: the difference in palatal shape at time T0 and T1 was statistically significant in both treatments (HE vs. LE). In the HE group, the change in shape also included the upper part of the palatal vault in the vertical dimension, while in the LE group the change in shape interested mainly palatal shelves and the lower portion of the palate.

Conclusions

Both LE and HE produce clinically significant changes in the morphology of the palatal vault.

研究目的本研究的目的是使用三维几何形态计量分析法,评估上颌扩容器(HE)和叶状扩容器(LE)扩容后腭部穹顶形状的变化:本研究共选取了 250 名上颌骨横向缺损患者(110 名男性,140 名女性)。在这项研究中,127 名患者接受了 HE 治疗,123 名患者接受了 LE 治疗:在治疗前(T0)和装置粘接 12 个月后(T1)获得数字牙科模型,并通过数字扫描仪进行处理。进行线性和形态计量分析以确定每种矫治器对牙齿测量和腭部形态的影响,并进行多元线性回归分析锚定和矫治器类型对最终形态的影响:形态计量分析表明,HE 组的腭穹有所降低,而 LE 组的腭穹保持不变:两种治疗方法(HE 与 LE)在 T0 和 T1 时的腭形差异均有显著的统计学意义。在 HE 组中,腭穹上部在垂直维度上的形状也发生了变化,而在 LE 组中,腭穹上部和下部的形状主要发生了变化:结论:LE和HE都会使腭穹的形态发生明显的临床变化。
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引用次数: 0
期刊
Orthodontics & Craniofacial Research
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