首页 > 最新文献

Orthodontics & Craniofacial Research最新文献

英文 中文
Dual role of Sfrp4 in bone remodelling during orthodontic tooth movement Sfrp4 在牙齿矫正过程中骨重塑的双重作用
IF 2.4 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-09-25 DOI: 10.1111/ocr.12858
Qing Wang, Xuan Wang, Yanzheng Chen, Jinsong Pan

Objectives

The objective of this study was to determine changes in gene expression by establishing an orthodontic tooth movement (OTM) rat model with appropriate and excessive orthodontic force.

Materials and Methods

Using a closed coil nickel-titanium spring, the OTM was carried out to apply a mesial force of 50 or 100 g to the maxillary first molars. Micro-CT, histological and immunohistochemical staining were used to evaluate the bone formation at the tension site and the bone resorption and bone formation at pressure site. Then RNA sequencing and bioinformatic analysis were performed.

Results

According to the results of the Mirco-CT scan of OTM rat models, both the 50 g group and the 100 g group showed variable degrees of reduction in alveolar bone density on the tension and pressure sides. The results of histological and immunohistochemical staining demonstrated that the periodontal tissue and osteogenic ability of the 50 g group were restored at the 14 days, while the 100 g group caused severe periodontal tissue damage. The GO and KEGG analysis results, as well as the number of differentially expressed genes (DEGs), varied depending on the loading time and value of appliance, according to the results of the RNA sequencing. And the immunohistochemical staining results showed that Sfrp4 functioned by efficiently influencing both bone formation and bone absorption.

Conclusions

Appropriate orthodontic force value could cause appropriate movement of teeth in rats without adverse periodontal damage. Simultaneously, distinct gene expression patterns were observed at various force levels and time intervals.

研究目的本研究的目的是通过建立具有适当和过度正畸力的正畸牙齿移动(OTM)大鼠模型来确定基因表达的变化:使用闭合线圈镍钛弹簧,对上颌第一磨牙施加 50 或 100 克的中轴力,进行 OTM。采用显微 CT、组织学和免疫组化染色评估受力部位的骨形成情况以及受压部位的骨吸收和骨形成情况。然后进行了 RNA 测序和生物信息学分析:OTM大鼠模型的Mirco-CT扫描结果显示,50 g组和100 g组大鼠张力侧和压力侧的牙槽骨密度均有不同程度的降低。组织学和免疫组化染色结果表明,50 克组的牙周组织和成骨能力在 14 天时得到了恢复,而 100 克组则造成了严重的牙周组织损伤。根据 RNA 测序结果,GO 和 KEGG 分析结果以及差异表达基因(DEGs)的数量随加载时间和用量值的不同而变化。免疫组化染色结果表明,Sfrp4 通过有效影响骨形成和骨吸收而发挥作用:结论:适当的矫治力值可使大鼠牙齿适当移动,而不会对牙周造成不良损伤。结论:适当的正畸力值可使大鼠的牙齿适当移动,而不会对牙周造成不良损伤。同时,在不同的力值和时间间隔下,可观察到不同的基因表达模式。
{"title":"Dual role of Sfrp4 in bone remodelling during orthodontic tooth movement","authors":"Qing Wang,&nbsp;Xuan Wang,&nbsp;Yanzheng Chen,&nbsp;Jinsong Pan","doi":"10.1111/ocr.12858","DOIUrl":"10.1111/ocr.12858","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The objective of this study was to determine changes in gene expression by establishing an orthodontic tooth movement (OTM) rat model with appropriate and excessive orthodontic force.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Using a closed coil nickel-titanium spring, the OTM was carried out to apply a mesial force of 50 or 100 g to the maxillary first molars. Micro-CT, histological and immunohistochemical staining were used to evaluate the bone formation at the tension site and the bone resorption and bone formation at pressure site. Then RNA sequencing and bioinformatic analysis were performed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>According to the results of the Mirco-CT scan of OTM rat models, both the 50 g group and the 100 g group showed variable degrees of reduction in alveolar bone density on the tension and pressure sides. The results of histological and immunohistochemical staining demonstrated that the periodontal tissue and osteogenic ability of the 50 g group were restored at the 14 days, while the 100 g group caused severe periodontal tissue damage. The GO and KEGG analysis results, as well as the number of differentially expressed genes (DEGs), varied depending on the loading time and value of appliance, according to the results of the RNA sequencing. And the immunohistochemical staining results showed that Sfrp4 functioned by efficiently influencing both bone formation and bone absorption.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Appropriate orthodontic force value could cause appropriate movement of teeth in rats without adverse periodontal damage. Simultaneously, distinct gene expression patterns were observed at various force levels and time intervals.</p>\u0000 </section>\u0000 </div>","PeriodicalId":19652,"journal":{"name":"Orthodontics & Craniofacial Research","volume":"28 1","pages":"175-186"},"PeriodicalIF":2.4,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142351421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Smartphone-based scans of palate models of newborns with cleft lip and palate: Outlooks for three-dimensional image capturing and machine learning plate tool 基于智能手机的唇腭裂新生儿腭部模型扫描:三维图像捕捉和机器学习平板工具展望。
IF 2.4 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-09-22 DOI: 10.1111/ocr.12859
José Wittor de Macêdo Santos, Andreas Albert Mueller, Benito K. Benitez, Yoriko Lill, Prasad Nalabothu, Francisco Wilker Mustafa Gomes Muniz

Objectives

To evaluate the performance of smartphone scanning applications (apps) in acquiring 3D meshes of cleft palate models. Secondarily, to validate a machine learning (ML) tool for computing automated presurgical plate (PSP).

Materials and Methods

We conducted a comparative analysis of two apps on 15 cleft palate models: five unilateral cleft lip and palate (UCLP), five bilateral cleft lip and palate (BCLP) and five isolated cleft palate (ICP). The scans were performed with and without a mirror to simulate intraoral acquisition. The 3D reconstructions were compared to control reconstructions acquired using a professional intraoral scanner using open-source software.

Results

Thirty 3D scans were acquired by each app, totalling 60 scans. The main findings were in the UCLP sample, where the KIRI scans without a mirror (0.22 ± 0.03 mm) had a good performance with a deviation from the ground truth comparable to the control group (0.14 ± 0.13 mm) (p = .653). Scaniverse scans with a mirror showed the lowest accuracy of all the samples. The ML tool was able to predict the landmarks and automatically generate the plates, except in ICP models. KIRI scans' plates showed better performance with (0.22 ± 0.06 mm) and without mirror (0.18 ± 0.05 mm), being comparable with controls (0.16 ± 0.08 mm) (p = .954 and p = .439, respectively).

Conclusions

KIRI Engine performed better in scanning UCLP models without a mirror. The ML tool showed a high capability for morphology recognition and automated PSP generation.

目的评估智能手机扫描应用程序(App)在获取腭裂模型三维网格方面的性能。其次,验证用于计算自动术前平板(PSP)的机器学习(ML)工具:我们在 15 个腭裂模型上对两款应用程序进行了比较分析:5 个单侧唇腭裂 (UCLP)、5 个双侧唇腭裂 (BCLP) 和 5 个孤立性腭裂 (ICP)。扫描时使用和不使用镜子,以模拟口内采集。三维重建结果与使用开源软件的专业口内扫描仪获得的对照重建结果进行了比较:每款应用程序均采集了 30 次三维扫描,共计 60 次扫描。主要结果显示,在 UCLP 样本中,不带镜子的 KIRI 扫描(0.22 ± 0.03 毫米)性能良好,与地面真实值(0.14 ± 0.13 毫米)的偏差与对照组相当(p = .653)。在所有样本中,带镜子的扫描宇宙精确度最低。除 ICP 模型外,ML 工具能够预测地标并自动生成平板。KIRI 扫描板在有镜子(0.22 ± 0.06 毫米)和无镜子(0.18 ± 0.05 毫米)时表现更好,与对照组(0.16 ± 0.08 毫米)相当(p = .954 和 p = .439):结论:KIRI 引擎在扫描没有镜子的 UCLP 模型时表现更好。ML 工具在形态识别和自动生成 PSP 方面表现出很高的能力。
{"title":"Smartphone-based scans of palate models of newborns with cleft lip and palate: Outlooks for three-dimensional image capturing and machine learning plate tool","authors":"José Wittor de Macêdo Santos,&nbsp;Andreas Albert Mueller,&nbsp;Benito K. Benitez,&nbsp;Yoriko Lill,&nbsp;Prasad Nalabothu,&nbsp;Francisco Wilker Mustafa Gomes Muniz","doi":"10.1111/ocr.12859","DOIUrl":"10.1111/ocr.12859","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To evaluate the performance of smartphone scanning applications (apps) in acquiring 3D meshes of cleft palate models. Secondarily, to validate a machine learning (ML) tool for computing automated presurgical plate (PSP).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>We conducted a comparative analysis of two apps on 15 cleft palate models: five unilateral cleft lip and palate (UCLP), five bilateral cleft lip and palate (BCLP) and five isolated cleft palate (ICP). The scans were performed with and without a mirror to simulate intraoral acquisition. The 3D reconstructions were compared to control reconstructions acquired using a professional intraoral scanner using open-source software.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Thirty 3D scans were acquired by each app, totalling 60 scans. The main findings were in the UCLP sample, where the KIRI scans without a mirror (0.22 ± 0.03 mm) had a good performance with a deviation from the ground truth comparable to the control group (0.14 ± 0.13 mm) (<i>p</i> = .653). Scaniverse scans with a mirror showed the lowest accuracy of all the samples. The ML tool was able to predict the landmarks and automatically generate the plates, except in ICP models. KIRI scans' plates showed better performance with (0.22 ± 0.06 mm) and without mirror (0.18 ± 0.05 mm), being comparable with controls (0.16 ± 0.08 mm) (<i>p</i> = .954 and <i>p</i> = .439, respectively).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>KIRI Engine performed better in scanning UCLP models without a mirror. The ML tool showed a high capability for morphology recognition and automated PSP generation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":19652,"journal":{"name":"Orthodontics & Craniofacial Research","volume":"28 1","pages":"166-174"},"PeriodicalIF":2.4,"publicationDate":"2024-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ocr.12859","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142292820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Wearing the mandibular advancement orthosis and dental movements: Contribution of a digital monitoring protocol. 佩戴下颌前突矫形器与牙齿运动:数字监测协议的贡献
IF 2.4 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-09-22 DOI: 10.1111/ocr.12860
M Gay, M Ducret, R Richert, G Buiret

Objectives: Oral appliance (OA) has been increasingly used for the treatment of obstructive sleep apnoea hypopnea syndrome (OSAHS). OAs work by propelling the mandible, increasing the upper airway calibre and reducing collapsibility. While they have shown efficacy in reducing OSAHS, long-term use can lead to adverse effects, such as dental displacement. The present study focuses on the impact on dental displacements of the NARVAL® computer-aided design and manufacturing OA from the ResMed laboratory.

Materials and methods: The study included 39 patients aged 18 or older who were treated for OSAHS using OAs initiated between 2019 and 2021 and had initial digital dental impressions. A new digital print was taken for each patient using the TRIOS 4 Wireless intra-oral scanner from 3SHAPE. Dental displacement was measured using a 3D system's GEOMAGIC design X 3D reverse engineering software. The study analysed different blocks of teeth in both the maxillary and mandibular arches. Statistical analysis was conducted to determine the significance of dental displacements.

Results: Patients had been wearing the OA for an average of 2.5 years. The study found dental displacements in both the maxillary and mandibular arches. However, these displacements were not statistically significant. Qualitative analysis revealed palatoversion and vestibuloversion, while quantitative analysis showed minor dental displacements.

Conclusion: This study on patients wearing the NARVAL® OA for an average of 2.5 years found dental displacements in both the maxillary and mandibular arches. However, these displacements were not statistically significant. The results suggest that the OA, designed using a complete digital workflow, did not significantly impact dental positions. To confirm the impact, further investigations with larger sample sizes, an exclusively digital protocol and a control group are required.

目的:口腔矫治器(OA)越来越多地被用于治疗阻塞性睡眠呼吸暂停低通气综合征(OSAHS)。口腔矫治器通过推动下颌骨、增加上气道口径和减少塌陷发挥作用。虽然它们在减少 OSAHS 方面有一定疗效,但长期使用会导致不良影响,如牙齿移位。本研究的重点是瑞思迈实验室的 NARVAL® 计算机辅助设计和制造 OA 对牙齿移位的影响:研究对象包括 39 名年龄在 18 岁或 18 岁以上的患者,他们在 2019 年至 2021 年期间开始使用 OA 治疗 OSAHS,并获得了初始数字牙模。使用 3SHAPE 的 TRIOS 4 无线口内扫描仪为每位患者采集了新的数字印模。使用三维系统的 GEOMAGIC design X 三维逆向工程软件测量牙齿位移。研究分析了上颌和下颌牙弓的不同牙块。研究还进行了统计分析,以确定牙齿位移的显著性:患者佩戴 OA 的时间平均为 2.5 年。研究发现,患者的上颌和下颌牙弓都出现了牙齿移位。然而,这些移位在统计学上并不显著。定性分析显示有腭内翻和前庭内翻,而定量分析显示有轻微的牙齿移位:这项对佩戴 NARVAL® OA 平均 2.5 年的患者进行的研究发现,上颌和下颌牙弓都有牙齿移位。不过,这些移位在统计学上并不显著。结果表明,使用完整的数字化工作流程设计的 OA 对牙齿位置没有明显影响。要确认其影响,还需要进行样本量更大、完全采用数字化方案和对照组的进一步研究。
{"title":"Wearing the mandibular advancement orthosis and dental movements: Contribution of a digital monitoring protocol.","authors":"M Gay, M Ducret, R Richert, G Buiret","doi":"10.1111/ocr.12860","DOIUrl":"https://doi.org/10.1111/ocr.12860","url":null,"abstract":"<p><strong>Objectives: </strong>Oral appliance (OA) has been increasingly used for the treatment of obstructive sleep apnoea hypopnea syndrome (OSAHS). OAs work by propelling the mandible, increasing the upper airway calibre and reducing collapsibility. While they have shown efficacy in reducing OSAHS, long-term use can lead to adverse effects, such as dental displacement. The present study focuses on the impact on dental displacements of the NARVAL® computer-aided design and manufacturing OA from the ResMed laboratory.</p><p><strong>Materials and methods: </strong>The study included 39 patients aged 18 or older who were treated for OSAHS using OAs initiated between 2019 and 2021 and had initial digital dental impressions. A new digital print was taken for each patient using the TRIOS 4 Wireless intra-oral scanner from 3SHAPE. Dental displacement was measured using a 3D system's GEOMAGIC design X 3D reverse engineering software. The study analysed different blocks of teeth in both the maxillary and mandibular arches. Statistical analysis was conducted to determine the significance of dental displacements.</p><p><strong>Results: </strong>Patients had been wearing the OA for an average of 2.5 years. The study found dental displacements in both the maxillary and mandibular arches. However, these displacements were not statistically significant. Qualitative analysis revealed palatoversion and vestibuloversion, while quantitative analysis showed minor dental displacements.</p><p><strong>Conclusion: </strong>This study on patients wearing the NARVAL® OA for an average of 2.5 years found dental displacements in both the maxillary and mandibular arches. However, these displacements were not statistically significant. The results suggest that the OA, designed using a complete digital workflow, did not significantly impact dental positions. To confirm the impact, further investigations with larger sample sizes, an exclusively digital protocol and a control group are required.</p>","PeriodicalId":19652,"journal":{"name":"Orthodontics & Craniofacial Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142292821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genome scan reveals several loci associated with torus palatinus 基因组扫描揭示了与腭弓有关的几个基因位点
IF 2.4 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-09-18 DOI: 10.1111/ocr.12857
Myoung Keun Lee, Ahmed M. El Sergani, Noah Herrick, Rebecca M. Green, Carmencita Padilla, Carmen J. Buxó, Ross E. Long, Consuelo Valencia-Ramirez, Claudia P. Restrepo Muñeton, Lina M. Moreno Uribe, Wasiu L. Adeyemo, Azeez Butali, Mary L. Marazita, John R. Shaffer, Seth M. Weinberg

Objective

Torus Palatinus (TP) is a common trait with an unclear aetiology. Although prior studies suggest a hereditary component, the genetic factors that influence TP risk remain unknown. The purpose of this study is to identify genetic variants associated with TP.

Materials and Methods

We assessed the TP status of 829 individuals from various ancestral backgrounds using 3D palate scans. We then carried out a genome-wide association study (GWAS) to identify common variants associated with TP. We also performed gene-based tests across the exome to investigate the role of low-frequency coding variants.

Results

Our GWAS did not identify any genome-wide significant signals but identified suggestive associations including hits on chromosomes 2, 5 and 17 with p-values less than 5 × 10−6. Candidate genes at these suggestive loci have been implicated in normal-range craniofacial features, syndromes with facial and oral malformations, and bone density. We did not find evidence that low-frequency coding variants influence TP risk. In addition, we failed to replicate associations identified in prior genetic studies of TP.

Conclusion

These findings suggest that multiple genes likely influence the development of TP. Independent replication will be required to confirm our suggestive associations.

目的腭裂(TP)是一种病因不明的常见特征。尽管先前的研究表明这与遗传有关,但影响腭裂风险的遗传因素仍然未知。本研究的目的是确定与腭裂相关的遗传变异。材料与方法我们利用三维腭部扫描评估了来自不同祖先背景的 829 人的腭裂状况。然后,我们开展了一项全基因组关联研究(GWAS),以确定与 TP 相关的常见变异。我们还在整个外显子组中进行了基于基因的测试,以研究低频编码变异的作用。结果我们的全基因组关联研究没有发现任何全基因组显著信号,但发现了一些提示性关联,包括 2 号、5 号和 17 号染色体上 p 值小于 5 × 10-6 的变异。这些提示性位点上的候选基因与正常范围的颅面特征、面部和口腔畸形综合征以及骨密度有关。我们没有发现低频编码变异影响 TP 风险的证据。此外,我们也未能复制之前的 TP 遗传研究中发现的关联。要证实我们的提示性关联,还需要独立的重复研究。
{"title":"Genome scan reveals several loci associated with torus palatinus","authors":"Myoung Keun Lee,&nbsp;Ahmed M. El Sergani,&nbsp;Noah Herrick,&nbsp;Rebecca M. Green,&nbsp;Carmencita Padilla,&nbsp;Carmen J. Buxó,&nbsp;Ross E. Long,&nbsp;Consuelo Valencia-Ramirez,&nbsp;Claudia P. Restrepo Muñeton,&nbsp;Lina M. Moreno Uribe,&nbsp;Wasiu L. Adeyemo,&nbsp;Azeez Butali,&nbsp;Mary L. Marazita,&nbsp;John R. Shaffer,&nbsp;Seth M. Weinberg","doi":"10.1111/ocr.12857","DOIUrl":"10.1111/ocr.12857","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Torus Palatinus (TP) is a common trait with an unclear aetiology. Although prior studies suggest a hereditary component, the genetic factors that influence TP risk remain unknown. The purpose of this study is to identify genetic variants associated with TP.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>We assessed the TP status of 829 individuals from various ancestral backgrounds using 3D palate scans. We then carried out a genome-wide association study (GWAS) to identify common variants associated with TP. We also performed gene-based tests across the exome to investigate the role of low-frequency coding variants.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Our GWAS did not identify any genome-wide significant signals but identified suggestive associations including hits on chromosomes 2, 5 and 17 with <i>p</i>-values less than 5 × 10<sup>−6</sup>. Candidate genes at these suggestive loci have been implicated in normal-range craniofacial features, syndromes with facial and oral malformations, and bone density. We did not find evidence that low-frequency coding variants influence TP risk. In addition, we failed to replicate associations identified in prior genetic studies of TP.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>These findings suggest that multiple genes likely influence the development of TP. Independent replication will be required to confirm our suggestive associations.</p>\u0000 </section>\u0000 </div>","PeriodicalId":19652,"journal":{"name":"Orthodontics & Craniofacial Research","volume":"28 1","pages":"159-165"},"PeriodicalIF":2.4,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ocr.12857","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142260934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correlation analysis of airway space and condylar morphology in bilateral idiopathic condylar resorption patients 双侧特发性髁突吸收患者气道空间与髁突形态的相关性分析
IF 2.4 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-09-15 DOI: 10.1111/ocr.12855
Yanfang Yu, Xueyan Xia, Lehan Xu, Xiaoyan Chen, Ningning Zhang, Mengjie Wu

To evaluate the airway space in bilateral idiopathic condylar resorption (ICR) patients and analyse the correlation between the morphological characteristics of the condyles and airway parameters. In all, 35 female patients with bilateral ICR (mean age: 21.6 years) and 35 age-matched female controls (mean age: 21.3 years) were included. Airway parameters were measured using CBCT. Independent T-tests were used to analyse the differences between the bilateral ICR group and the control group, and then the correlation between airway parameters and condylar parameters was detected using Pearson correlation analysis. p < .05 was considered statistically significant. Patients with bilateral ICR showed a significant decrease in airway volume, minimum axial area and sagittal sectional area (p < .05). The bilateral condylar axial angle positively correlated with airway volume and sagittal sectional area (p < .05). In contrast, the bilateral condylar neck angle negatively correlated with sagittal sectional area (p < .05). None of the condylar parameters showed a correlation with minimum axial area of the airway in the bilateral ICR group (p > .05). Bilateral ICR significantly affects patients' airway space. The condylar axial angle and neck angle correlate with airway parameters.

目的:评估双侧特发性髁突吸收(ICR)患者的气道空间,并分析髁突形态特征与气道参数之间的相关性。共纳入 35 名双侧特发性髁状突吸收(ICR)女性患者(平均年龄:21.6 岁)和 35 名年龄匹配的女性对照组患者(平均年龄:21.3 岁)。气道参数使用 CBCT 测量。使用独立 T 检验分析双侧 ICR 组与对照组之间的差异,然后使用皮尔逊相关分析检测气道参数与髁突参数之间的相关性。双侧 ICR 患者的气道容积、最小轴向面积和矢状切面面积均显著减少(p < .05)。双侧髁状突轴向角度与气道容积和矢状切面面积呈正相关(p <.05)。相反,双侧髁状突颈部角度与矢状切面面积呈负相关(p < .05)。在双侧 ICR 组中,没有一个髁状突参数与气道最小轴向面积相关(p >.05)。双侧 ICR 明显影响患者的气道空间。髁状突轴向角度和颈部角度与气道参数相关。
{"title":"Correlation analysis of airway space and condylar morphology in bilateral idiopathic condylar resorption patients","authors":"Yanfang Yu,&nbsp;Xueyan Xia,&nbsp;Lehan Xu,&nbsp;Xiaoyan Chen,&nbsp;Ningning Zhang,&nbsp;Mengjie Wu","doi":"10.1111/ocr.12855","DOIUrl":"10.1111/ocr.12855","url":null,"abstract":"<p>To evaluate the airway space in bilateral idiopathic condylar resorption (ICR) patients and analyse the correlation between the morphological characteristics of the condyles and airway parameters. In all, 35 female patients with bilateral ICR (mean age: 21.6 years) and 35 age-matched female controls (mean age: 21.3 years) were included. Airway parameters were measured using CBCT. Independent T-tests were used to analyse the differences between the bilateral ICR group and the control group, and then the correlation between airway parameters and condylar parameters was detected using Pearson correlation analysis. <i>p</i> &lt; .05 was considered statistically significant. Patients with bilateral ICR showed a significant decrease in airway volume, minimum axial area and sagittal sectional area (<i>p</i> &lt; .05). The bilateral condylar axial angle positively correlated with airway volume and sagittal sectional area (<i>p</i> &lt; .05). In contrast, the bilateral condylar neck angle negatively correlated with sagittal sectional area (<i>p</i> &lt; .05). None of the condylar parameters showed a correlation with minimum axial area of the airway in the bilateral ICR group (<i>p</i> &gt; .05). Bilateral ICR significantly affects patients' airway space. The condylar axial angle and neck angle correlate with airway parameters.</p>","PeriodicalId":19652,"journal":{"name":"Orthodontics & Craniofacial Research","volume":"28 1","pages":"151-158"},"PeriodicalIF":2.4,"publicationDate":"2024-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142260935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Variation of chin morphology and mandibular incisor length in different facial divergence patterns: New insights from CBCT records 不同面部分化模式下下巴形态和下颌门齿长度的变化:来自 CBCT 记录的新见解
IF 2.4 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-09-11 DOI: 10.1111/ocr.12856
Joseph G. Ghafari, Eliane G. Ziade, Ammar Kassab, Maria Saadeh, Anthony T. Macari

Aim

Evaluate constitutional differences in chin morphology and volume, and mandibular tooth size, between different facial divergence patterns.

Materials and Methods

The sample consisted of 284 pretreatment cone beam computed tomography (CBCT) images of growing and non-growing patients who were stratified into 4 groups based on mandibular plane inclination to cranial base (SN) angle. Linear and angular measurements were made on the lateral CBCT images: mandibular lateral incisor crown (I-C) total (I-A) lengths, the distances between point D (centre of symphysis) and both incisor apex (D-A) and menton (D-Me) and between cemento-enamel junction and menton (CEJ-Me); chin width at the level of the central incisor apex (CWA) and point D (CWD); and the angles of the anterior and posterior symphyseal slopes. The volume of the symphysis was measured using a specialized 3D imaging software. Group differences and associations between parameters were gauged through the three-way ANOVA analysis.

Results

I-C, I-A, D-A, D-Me and CEJ-Me were greater in the hyperdivergent group (p < .001). CWA and CWD were wider in the hypodivergent group (p = .003). Volume of the chin and inter-slope angles were similar in all groups (p > .05). The anterior slope angle decreased with hyperdivegence (p < .005) in opposite pattern to the posterior slope angle (p < .005).

Conclusions

Shape differences in mandibular symphysis were observed between opposite divergence patterns. Mandibular incisors were longer with hyperdivergence and shorter with hypodivergence. However, chin volumes were similar across divergence groups. These findings underline the role of genetic and environmental factors that impact facial growth.

材料和方法样本包括 284 张生长期和非生长期患者的锥形束计算机断层扫描 (CBCT) 图像,这些患者根据下颌平面倾斜度与颅底 (SN) 角度被分为 4 组。在 CBCT 侧边图像上进行了线性和角度测量:下颌侧切牙牙冠(I-C)总长度(I-A)、D 点(牙合中心)与切牙顶点(D-A)和牙弓(D-Me)之间的距离以及牙本质-釉质交界处与牙弓(CEJ-Me)之间的距离;中切牙顶点(CWA)和 D 点(CWD)水平的颏宽;以及前后牙合斜坡的角度。使用专门的三维成像软件测量了干骺端的体积。结果I-C、I-A、D-A、D-Me和CEJ-Me在超发散组更大(p <.001)。低发散组的 CWA 和 CWD 更宽(p = .003)。所有组的颏部体积和斜坡间角相似(p > .05)。结论在不同的发散模式之间观察到下颌骨干骺端的形状差异。下颌切牙在高分异时较长,在低分异时较短。然而,各分化组的颏部体积相似。这些发现强调了遗传和环境因素对面部生长的影响。
{"title":"Variation of chin morphology and mandibular incisor length in different facial divergence patterns: New insights from CBCT records","authors":"Joseph G. Ghafari,&nbsp;Eliane G. Ziade,&nbsp;Ammar Kassab,&nbsp;Maria Saadeh,&nbsp;Anthony T. Macari","doi":"10.1111/ocr.12856","DOIUrl":"10.1111/ocr.12856","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Evaluate constitutional differences in chin morphology and volume, and mandibular tooth size, between different facial divergence patterns.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>The sample consisted of 284 pretreatment cone beam computed tomography (CBCT) images of growing and non-growing patients who were stratified into 4 groups based on mandibular plane inclination to cranial base (SN) angle. Linear and angular measurements were made on the lateral CBCT images: mandibular lateral incisor crown (I-C) total (I-A) lengths, the distances between point D (centre of symphysis) and both incisor apex (D-A) and menton (D-Me) and between cemento-enamel junction and menton (CEJ-Me); chin width at the level of the central incisor apex (CWA) and point D (CWD); and the angles of the anterior and posterior symphyseal slopes. The volume of the symphysis was measured using a specialized 3D imaging software. Group differences and associations between parameters were gauged through the three-way ANOVA analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>I-C, I-A, D-A, D-Me and CEJ-Me were greater in the hyperdivergent group (<i>p</i> &lt; .001). CWA and CWD were wider in the hypodivergent group (<i>p</i> = .003). Volume of the chin and inter-slope angles were similar in all groups (<i>p</i> &gt; .05). The anterior slope angle decreased with hyperdivegence (<i>p</i> &lt; .005) in opposite pattern to the posterior slope angle (<i>p</i> &lt; .005).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Shape differences in mandibular symphysis were observed between opposite divergence patterns. Mandibular incisors were longer with hyperdivergence and shorter with hypodivergence. However, chin volumes were similar across divergence groups. These findings underline the role of genetic and environmental factors that impact facial growth.</p>\u0000 </section>\u0000 </div>","PeriodicalId":19652,"journal":{"name":"Orthodontics & Craniofacial Research","volume":"28 1","pages":"142-150"},"PeriodicalIF":2.4,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142186023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Accuracy of measurements on CBCT-generated digital models using different exposure parameters (in vitro study) 使用不同曝光参数对 CBCT 生成的数字模型进行测量的准确性(体外研究)。
IF 2.4 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-09-08 DOI: 10.1111/ocr.12854
Noura Ibrahim, Hassan Mohamed Abouelkheir, Noha Mohamed Elkersh

Introduction

Dental imaging comprises a wide range of techniques and modalities, each with different diagnostic features influenced by numerous parameters, all of which contribute to the precision and effectiveness of dental evaluations and treatments. This study examined the dimensional reproducibility of arch measurements from CBCT scans with different voxel sizes and exposure parameters compared to a reference model from Extra-oral scanners (EOS) and how these parameters affected digital matching and diagnostic image quality.

Methods

A diagnostic observational study of arch dimensions, including inter-canine, inter-premolar, intermolar, arch width and arch length, was conducted on digital models (DMs) created from 65 CBCT scans of a full dentate epoxy maxillary model. The measurements obtained from EOS scans served as the control for the study. Normality was tested with the Shapiro–Wilk test, comparisons used the Kruskal–Wallis test with Bonferroni-adjusted pairwise comparisons for significant results, and data were analysed using IBM SPSS (Version 26.0), with significance set at p < .05.

Results

Significant deviations were revealed among study groups, with group I (smallest voxel size) consistently displaying the lowest values, mean (SD) deviation was reported as 0.01 (0.006) and group IV (lowest kV value) exhibiting the highest deviations, mean (SD) deviation of 0.16 (0.17).

Conclusion

Combining a small voxel size (0.12 mm) with high milliampere (8 mA) and kilovoltage (90 kV) settings in CBCT ensured detailed anatomical visualization and accurate linear measurements, crucial for precise dental assessments, and emphasizing the necessity for strict control over CBCT parameters in dental applications.

导言:牙科成像由多种技术和模式组成,每种技术和模式都有不同的诊断特征,受众多参数的影响,所有这些都有助于提高牙科评估和治疗的精确性和有效性。本研究将不同体素大小和曝光参数的 CBCT 扫描结果与口外扫描仪(EOS)的参考模型进行比较,考察其牙弓测量值的尺寸再现性,以及这些参数对数字匹配和诊断图像质量的影响:通过对65个环氧树脂上颌全齿模型的CBCT扫描创建的数字模型(DMs),对牙弓尺寸(包括犬间、腭间、臼间、牙弓宽度和牙弓长度)进行了诊断观察研究。通过 EOS 扫描获得的测量结果作为研究的对照。正态性采用 Shapiro-Wilk 检验,比较采用 Kruskal-Wallis 检验,显著结果采用 Bonferroni-adjusted 配对比较,数据采用 IBM SPSS(26.0 版)分析,显著性设置为 p:各研究组之间存在显著偏差,第一组(体素尺寸最小)始终显示最低值,平均(标清)偏差为 0.01(0.006),第四组(kV 值最低)显示最高偏差,平均(标清)偏差为 0.16(0.17):将 CBCT 中的小体素尺寸(0.12 毫米)与高毫安培(8 毫安)和高电压(90 千伏)设置相结合,可确保详细的解剖可视化和精确的线性测量,这对精确的牙科评估至关重要,同时强调了在牙科应用中严格控制 CBCT 参数的必要性。
{"title":"Accuracy of measurements on CBCT-generated digital models using different exposure parameters (in vitro study)","authors":"Noura Ibrahim,&nbsp;Hassan Mohamed Abouelkheir,&nbsp;Noha Mohamed Elkersh","doi":"10.1111/ocr.12854","DOIUrl":"10.1111/ocr.12854","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Dental imaging comprises a wide range of techniques and modalities, each with different diagnostic features influenced by numerous parameters, all of which contribute to the precision and effectiveness of dental evaluations and treatments. This study examined the dimensional reproducibility of arch measurements from CBCT scans with different voxel sizes and exposure parameters compared to a reference model from Extra-oral scanners (EOS) and how these parameters affected digital matching and diagnostic image quality.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A diagnostic observational study of arch dimensions, including inter-canine, inter-premolar, intermolar, arch width and arch length, was conducted on digital models (DMs) created from 65 CBCT scans of a full dentate epoxy maxillary model. The measurements obtained from EOS scans served as the control for the study. Normality was tested with the Shapiro–Wilk test, comparisons used the Kruskal–Wallis test with Bonferroni-adjusted pairwise comparisons for significant results, and data were analysed using IBM SPSS (Version 26.0), with significance set at <i>p</i> &lt; .05.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Significant deviations were revealed among study groups, with group I (smallest voxel size) consistently displaying the lowest values, mean (SD) deviation was reported as 0.01 (0.006) and group IV (lowest kV value) exhibiting the highest deviations, mean (SD) deviation of 0.16 (0.17).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Combining a small voxel size (0.12 mm) with high milliampere (8 mA) and kilovoltage (90 kV) settings in CBCT ensured detailed anatomical visualization and accurate linear measurements, crucial for precise dental assessments, and emphasizing the necessity for strict control over CBCT parameters in dental applications.</p>\u0000 </section>\u0000 </div>","PeriodicalId":19652,"journal":{"name":"Orthodontics & Craniofacial Research","volume":"28 1","pages":"133-141"},"PeriodicalIF":2.4,"publicationDate":"2024-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142154751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of maxillary expansion on the sagittal skeletal and dental parameters of growing Class II patients: A systematic review with meta-analysis 上颌骨扩张对生长期 II 类患者矢状骨骼和牙齿参数的影响:系统回顾与荟萃分析。
IF 2.4 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-09-08 DOI: 10.1111/ocr.12852
Davide Cannatà, Marzio Galdi, Carmine Scelza, Vittorio Simeon, Francesco Giordano, Stefano Martina

A “spontaneous” correction of the Class II malocclusion has been described after maxillary expansion (ME) treatment. The aim of the present review was to systematically summarize changes in the sagittal dentoskeletal parameters of growing Class II patients after ME. The study protocol was developed according to the PRISMA statement and registered in PROSPERO before literature search, data extraction and analysis. The PICO model was followed in the definition of the research question, search strategies and study selection criteria. Randomized and non-randomized studies on the sagittal effects of ME published in English language without date restrictions were electronically searched across the Cochrane Library, Scopus and MEDLINE/PubMed databases. Changes in sagittal dentoskeletal cephalometric parameters were analysed. The risk of bias in randomized and nonrandomized studies was assessed using the Rob2 and ROBINS-I tools, respectively. A narrative synthesis was performed, focusing on the investigated population, intervention, comparison, and main outcomes. Pairwise meta-analyses were used to compare the outcomes assessed in subjects who underwent ME versus untreated subjects. Ten studies met the inclusion criteria, four were included in the pairwise meta-analyses due to the presence of a control group. Slight but significant improvements in OVJ (MD: −0.36; 95%; CI [−0.69 to −0.01]; p = .04) and 6/6 molar relation (MD: 1.5; 95%; CI [0.69 to 1.61]; p < .0001) were found in patients who underwent ME compared with untreated subjects, whereas no improvement in skeletal parameters was observed. However, the limitations of a small body of moderate-quality evidence and possible confounding factors should be considered. Evidence on the sagittal skeletal and dental effects of ME in Class II patients is still ambiguous, suggesting the need for more clinical trials, including appropriate control subjects, randomization and blinding during outcome assessment.

上颌扩弓(ME)治疗后,II类错牙合畸形可 "自发 "矫正。本综述旨在系统地总结生长发育中的II类患者在接受ME治疗后矢状面牙骨架参数的变化。研究方案是根据 PRISMA 声明制定的,并在文献检索、数据提取和分析前在 PROSPERO 上进行了注册。在确定研究问题、搜索策略和研究选择标准时遵循了 PICO 模式。在 Cochrane 图书馆、Scopus 和 MEDLINE/PubMed 数据库中以电子方式检索了以英语发表的关于 ME 的矢状面效应的随机和非随机研究,无日期限制。分析了矢状牙骨头面测量参数的变化。分别使用 Rob2 和 ROBINS-I 工具评估了随机研究和非随机研究的偏倚风险。进行了叙述性综述,重点关注调查人群、干预措施、比较和主要结果。使用配对荟萃分析比较了接受ME治疗的受试者与未接受治疗的受试者的评估结果。有 10 项研究符合纳入标准,其中 4 项研究因存在对照组而被纳入配对荟萃分析。OVJ(MD:-0.36;95%;CI [-0.69至-0.01];p = .04)和6/6臼齿关系(MD:1.5;95%;CI [0.69至1.61];p = .05)有轻微但明显的改善。
{"title":"Impact of maxillary expansion on the sagittal skeletal and dental parameters of growing Class II patients: A systematic review with meta-analysis","authors":"Davide Cannatà,&nbsp;Marzio Galdi,&nbsp;Carmine Scelza,&nbsp;Vittorio Simeon,&nbsp;Francesco Giordano,&nbsp;Stefano Martina","doi":"10.1111/ocr.12852","DOIUrl":"10.1111/ocr.12852","url":null,"abstract":"<p>A “spontaneous” correction of the Class II malocclusion has been described after maxillary expansion (ME) treatment. The aim of the present review was to systematically summarize changes in the sagittal dentoskeletal parameters of growing Class II patients after ME. The study protocol was developed according to the PRISMA statement and registered in PROSPERO before literature search, data extraction and analysis. The PICO model was followed in the definition of the research question, search strategies and study selection criteria. Randomized and non-randomized studies on the sagittal effects of ME published in English language without date restrictions were electronically searched across the Cochrane Library, Scopus and MEDLINE/PubMed databases. Changes in sagittal dentoskeletal cephalometric parameters were analysed. The risk of bias in randomized and nonrandomized studies was assessed using the Rob2 and ROBINS-I tools, respectively. A narrative synthesis was performed, focusing on the investigated population, intervention, comparison, and main outcomes. Pairwise meta-analyses were used to compare the outcomes assessed in subjects who underwent ME versus untreated subjects. Ten studies met the inclusion criteria, four were included in the pairwise meta-analyses due to the presence of a control group. Slight but significant improvements in OVJ (MD: −0.36; 95%; CI [−0.69 to −0.01]; <i>p</i> = .04) and 6/6 molar relation (MD: 1.5; 95%; CI [0.69 to 1.61]; <i>p</i> &lt; .0001) were found in patients who underwent ME compared with untreated subjects, whereas no improvement in skeletal parameters was observed. However, the limitations of a small body of moderate-quality evidence and possible confounding factors should be considered. Evidence on the sagittal skeletal and dental effects of ME in Class II patients is still ambiguous, suggesting the need for more clinical trials, including appropriate control subjects, randomization and blinding during outcome assessment.</p>","PeriodicalId":19652,"journal":{"name":"Orthodontics & Craniofacial Research","volume":"28 1","pages":"116-132"},"PeriodicalIF":2.4,"publicationDate":"2024-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142154752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Three-dimensional assessment on digital cast of spontaneous upper first molar distorotation after Ni-ti leaf springs expander and rapid maxillary expander: A two-centre randomized controlled trial 对Ni-ti叶状弹簧扩张器和快速上颌扩张器术后自发上第一磨牙歪斜的数字铸模进行三维评估:双中心随机对照试验。
IF 2.4 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-09-08 DOI: 10.1111/ocr.12849
Andrea Abate, Alessandro Ugolini, Alessandro Bruni, Vincenzo Quinzi, Valentina Lanteri
<div> <section> <h3> Objective</h3> <p>The aim of this randomized controlled trial (RCT) was to evaluate the spontaneous distorotation of upper first permanent molars and the transverse dentoalveolar changes on digital casts in growing patients following maxillary expansion treatment using either the Leaf Expander® or the rapid maxillary expander (RME), both anchored to the deciduous second molar.</p> </section> <section> <h3> Trial Design and Setting</h3> <p>This study was a two-arm, parallel-assignment, RCT with a dual-centre design conducted at two teaching hospitals in Italy.</p> </section> <section> <h3> Participants</h3> <p>Inclusion criteria included maxillary transverse deficiency, prepubertal development stage (cervical vertebra maturation stage [CVMS] 1–2) and early mixed dentition with fully erupted upper first permanent molars. Exclusion criteria were systemic diseases or syndromes, CVMS 3–6, agenesis of upper second premolars, unavailability of the second deciduous molar for anchorage and Class III malocclusion.</p> </section> <section> <h3> Randomization</h3> <p>Patients were randomly assigned to the Leaf Expander® or RME group using a computer-generated randomization list created by a central randomization centre. Randomization was conducted immediately before the start of treatment.</p> </section> <section> <h3> Intervention</h3> <p>The intervention involved treatment with either the Leaf Expander® or the RME. Both devices were anchored to the second deciduous molars. Following randomization, patients were further categorized based on the presence of no crossbite, unilateral crossbite or bilateral crossbite.</p> </section> <section> <h3> Main Outcome Measure</h3> <p>The primary outcome measure was the distorotation of the upper first molar (U6). Secondary outcomes included measurements of interdental linear dimensions, specifically upper inter-canine width (53–63), upper inter-molar width (MV16–MV26) and upper inter-deciduous second molar width (55–65).</p> </section> <section> <h3> Blinding</h3> <p>The examiner analysing the digital casts was blinded to the treatment groups to prevent detection bias and ensure objective assessment. However, due to the nature of the intervention, blinding was not feasible for the patients and clinic
研究目的本随机对照试验(RCT)的目的是评估生长期患者在使用叶片扩张器(Leaf Expander®)或快速上颌扩张器(RME)进行上颌扩张治疗后,上第一恒磨牙的自发旋转情况以及数字铸模上牙槽横向的变化情况:本研究是一项双臂、平行分配、RCT 双中心研究,在意大利的两家教学医院进行:纳入标准包括上颌横向缺失、青春期前发育阶段(颈椎成熟阶段 [CVMS] 1-2)和上第一恒磨牙完全萌出的早期混合牙列。排除标准为全身性疾病或综合征、颈椎成熟期 3-6、上第二前磨牙缺失、第二乳磨牙无法锚固以及 III 类错合畸形:患者被随机分配到Leaf Expander®或RME组,随机名单由中央随机中心通过计算机生成。随机化在治疗开始前进行:干预措施包括使用利图叶片扩张器® 或 RME 进行治疗。两种装置都固定在第二颗臼齿上。主要结果测量:主要结果测量是上第一磨牙(U6)的扭转。次要结果包括牙间线性尺寸的测量,特别是上犬齿间宽度(53-63)、上磨牙间宽度(MV16-MV26)和上臼齿间宽度(55-65):盲法:为防止检测偏差并确保评估的客观性,分析数字铸模的检查员对治疗组实行盲法。然而,由于干预的性质,对患者和参与治疗的临床医生进行盲法是不可行的:共招募了 150 名患者,并将他们随机分配到两组:75 人分配到叶片扩张器® 组,75 人分配到 RME 组。招募工作于 2021 年 11 月开始,2022 年 11 月结束。在进行分析时,试验已经结束,没有持续的随访。方差分析测试表明,叶片扩张器®组和 RME 组的三个分组(无交叉、单侧交叉和双侧交叉)在 T0 时均无显著差异。与 RME 相比,Leaf Expander® 在单侧交叉咬合亚组中的扭曲程度明显更大(p = .014)。就臼齿的总歪斜度而言,与传统的 RME(7.83°)相比,Leaf Expander®矫治器的效果明显更大(12.66°)。线性回归分析表明,扩容程度与臼齿旋转程度之间存在明显的相关性:结论:将上颌扩弓器粘结在第二颗落臼齿上时,会产生明显的自发臼齿旋转。与传统的 RME 相比,Leaf Expander® 的臼齿旋转程度明显更大。臼齿变形的程度与第二颗臼齿的扩张程度相关:该试验已在 ClinicalTrials.gov 注册(ID:NCT05135962)。
{"title":"Three-dimensional assessment on digital cast of spontaneous upper first molar distorotation after Ni-ti leaf springs expander and rapid maxillary expander: A two-centre randomized controlled trial","authors":"Andrea Abate,&nbsp;Alessandro Ugolini,&nbsp;Alessandro Bruni,&nbsp;Vincenzo Quinzi,&nbsp;Valentina Lanteri","doi":"10.1111/ocr.12849","DOIUrl":"10.1111/ocr.12849","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Objective&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The aim of this randomized controlled trial (RCT) was to evaluate the spontaneous distorotation of upper first permanent molars and the transverse dentoalveolar changes on digital casts in growing patients following maxillary expansion treatment using either the Leaf Expander® or the rapid maxillary expander (RME), both anchored to the deciduous second molar.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Trial Design and Setting&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This study was a two-arm, parallel-assignment, RCT with a dual-centre design conducted at two teaching hospitals in Italy.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Participants&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Inclusion criteria included maxillary transverse deficiency, prepubertal development stage (cervical vertebra maturation stage [CVMS] 1–2) and early mixed dentition with fully erupted upper first permanent molars. Exclusion criteria were systemic diseases or syndromes, CVMS 3–6, agenesis of upper second premolars, unavailability of the second deciduous molar for anchorage and Class III malocclusion.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Randomization&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Patients were randomly assigned to the Leaf Expander® or RME group using a computer-generated randomization list created by a central randomization centre. Randomization was conducted immediately before the start of treatment.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Intervention&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The intervention involved treatment with either the Leaf Expander® or the RME. Both devices were anchored to the second deciduous molars. Following randomization, patients were further categorized based on the presence of no crossbite, unilateral crossbite or bilateral crossbite.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Main Outcome Measure&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The primary outcome measure was the distorotation of the upper first molar (U6). Secondary outcomes included measurements of interdental linear dimensions, specifically upper inter-canine width (53–63), upper inter-molar width (MV16–MV26) and upper inter-deciduous second molar width (55–65).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Blinding&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The examiner analysing the digital casts was blinded to the treatment groups to prevent detection bias and ensure objective assessment. However, due to the nature of the intervention, blinding was not feasible for the patients and clinic","PeriodicalId":19652,"journal":{"name":"Orthodontics & Craniofacial Research","volume":"28 1","pages":"104-115"},"PeriodicalIF":2.4,"publicationDate":"2024-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ocr.12849","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142154753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preventive and reparative effects of low-level laser therapy on orthodontically induced inflammatory root resorption—An animal study 低强度激光疗法对正畸引起的炎性牙根吸收的预防和修复作用--一项动物研究。
IF 2.4 3区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-09-03 DOI: 10.1111/ocr.12853
Bowen Xu, Rina Du, Linna Bai, Kai Yang

Background

Orthodontically induced inflammatory root resorption (OIIRR) is one of the most important side effects of orthodontic treatment. Low-level laser therapy (LLLT) is a useful way to reduce the orthodontic treatment duration and may have some effect on preventing and repairing OIIRR. However, the specific effects of LLLT on OIIRR remain unknown.

Objective

Our research aimed to evaluate the Dentin Sialophosphoprotein (DSPP) expression level and root resorption volume during treatment and retention to explore the role of LLLT in preventing and repairing OIIRR.

Methods

Thirty-seven 6-week-old male Sprague–Dawley rats were selected to establish an OIIRR model; the rats were divided into Group B (blank), Group F (force), Group F(LLLT) (force and LLLT), Group F+R (force and retention) and Group F+R(LLLT) (force, retention and LLLT). The root resorption volume of the distal buccal root and mesial root in the maxillary left first molar was calculated by micro-CT, and the DSPP expression level on the compression side of the periodontal ligament was analysed by immunohistochemical staining.

Results

The resorption volume in Group F was greater than that in Group F(LLLT). For the mesial root, the volume in Group F was greater than that in Groups F+R and F+R(LLLT). For the distal buccal root, the volume in Groups F and F+R was greater than that in Group F+R(LLLT). The DSPP level in Group F(LLLT) was greater than that in Group F and there was no difference between Groups F+R and F+R(LLLT).

Conclusions

LLLT has a certain preventive effect and a limited reparative effect on OIIRR in rats.

背景:正畸诱发的炎性牙根吸收(OIIRR)是正畸治疗最重要的副作用之一。低强度激光疗法(LLLT)是缩短正畸治疗时间的有效方法,并可能对预防和修复 OIIRR 有一定作用。然而,LLLT 对 OIIRR 的具体影响仍然未知:我们的研究旨在评估治疗和保持期间牙本质鞘磷蛋白(DSPP)的表达水平和牙根吸收量,以探讨 LLLT 在预防和修复 OIIRR 中的作用:方法:选择37只6周龄雄性Sprague-Dawley大鼠建立OIIRR模型,将其分为B组(空白)、F组(用力)、F(LLLT)组(用力和LLLT)、F+R组(用力和保留)和F+R(LLLT)组(用力、保留和LLLT)。通过显微 CT 计算上颌左侧第一磨牙远端颊侧根和中侧根的牙根吸收量,并通过免疫组化染色分析牙周韧带受压侧的 DSPP 表达水平:结果:F组的吸收量大于F(LLLT)组。就中牙根而言,F 组的吸收量大于 F+R 组和 F+R(LLLT)组。就颊根远端而言,F 组和 F+R 组的体积大于 F+R(LLLT)组。F 组(LLLT)的 DSPP 水平高于 F 组,F+R 组和 F+R(LLLT)组之间没有差异:结论:LLLT 对大鼠 OIIRR 有一定的预防作用和有限的修复作用。
{"title":"Preventive and reparative effects of low-level laser therapy on orthodontically induced inflammatory root resorption—An animal study","authors":"Bowen Xu,&nbsp;Rina Du,&nbsp;Linna Bai,&nbsp;Kai Yang","doi":"10.1111/ocr.12853","DOIUrl":"10.1111/ocr.12853","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Orthodontically induced inflammatory root resorption (OIIRR) is one of the most important side effects of orthodontic treatment. Low-level laser therapy (LLLT) is a useful way to reduce the orthodontic treatment duration and may have some effect on preventing and repairing OIIRR. However, the specific effects of LLLT on OIIRR remain unknown.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Our research aimed to evaluate the Dentin Sialophosphoprotein (DSPP) expression level and root resorption volume during treatment and retention to explore the role of LLLT in preventing and repairing OIIRR.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Thirty-seven 6-week-old male Sprague–Dawley rats were selected to establish an OIIRR model; the rats were divided into Group B (blank), Group F (force), Group F(LLLT) (force and LLLT), Group F+R (force and retention) and Group F+R(LLLT) (force, retention and LLLT). The root resorption volume of the distal buccal root and mesial root in the maxillary left first molar was calculated by micro-CT, and the DSPP expression level on the compression side of the periodontal ligament was analysed by immunohistochemical staining.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The resorption volume in Group F was greater than that in Group F(LLLT). For the mesial root, the volume in Group F was greater than that in Groups F+R and F+R(LLLT). For the distal buccal root, the volume in Groups F and F+R was greater than that in Group F+R(LLLT). The DSPP level in Group F(LLLT) was greater than that in Group F and there was no difference between Groups F+R and F+R(LLLT).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>LLLT has a certain preventive effect and a limited reparative effect on OIIRR in rats.</p>\u0000 </section>\u0000 </div>","PeriodicalId":19652,"journal":{"name":"Orthodontics & Craniofacial Research","volume":"28 1","pages":"95-103"},"PeriodicalIF":2.4,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142120361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Orthodontics & Craniofacial Research
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1