Pub Date : 2024-05-03eCollection Date: 2024-04-01DOI: 10.1002/oto2.141
Emily Y Huang, Ryan Park, Erica Park, Matthew A Firpo, Albert H Park
Objective: Although pediatric otolaryngology providers are reported to garner lower patient satisfaction than adults, this difference is not well characterized. This study investigates whether patient satisfaction differences exist in providers who treat both pediatric and adult patients.
Study design: Retrospective review.
Setting: Tertiary medical center.
Methods: In this cross-sectional study, Press Ganey surveys (PGS) completed by patients or parents on their first-time visit with 5 general otolaryngology providers from July 2014 to March 2022 were analyzed. Surveys were categorized by child (<18 years old) or adult and consisted of 14 items including 6 service domains of access, visit, nursing, provider, personal issues, and assessment. Analysis was performed with Walsh's t test and analysis of variance. Multivariable logistic regression, controlling for wait times and provider, evaluated the likelihood of highest satisfaction scores (HI-SCORES) based on age.
Results: A total of 2549 patients (135 pediatric, 2414 adults) completed the PGS on their initial visit. There was no significant difference in the mean overall satisfaction scores between pediatric and adult patients. Further analysis of service domains among pediatric patients found the mean score in the access domain to be higher for the 6- to 11-year-old age group (0-5 years old: 85.5 ± 20.5 [mean ± SD], 6-11 years old: 94.7 ± 11.5, 12-17 years old: 87.3 ± 15.4, P = .03). Pediatric patients did not have a significantly higher likelihood (odds ratio = 1.1, 95% confidence interval: 0.8-1.6, P > .05) of reporting HI-SCORES compared to adults after covariate adjustment.
Conclusion: There was no significant difference in patient satisfaction scores for providers who treat pediatric and adult patients utilizing the same facility and scheduling team.
{"title":"Comparing Satisfaction Among Providers Treating Both Pediatric and Adult Otolaryngology Patients.","authors":"Emily Y Huang, Ryan Park, Erica Park, Matthew A Firpo, Albert H Park","doi":"10.1002/oto2.141","DOIUrl":"https://doi.org/10.1002/oto2.141","url":null,"abstract":"<p><strong>Objective: </strong>Although pediatric otolaryngology providers are reported to garner lower patient satisfaction than adults, this difference is not well characterized. This study investigates whether patient satisfaction differences exist in providers who treat both pediatric and adult patients.</p><p><strong>Study design: </strong>Retrospective review.</p><p><strong>Setting: </strong>Tertiary medical center.</p><p><strong>Methods: </strong>In this cross-sectional study, Press Ganey surveys (PGS) completed by patients or parents on their first-time visit with 5 general otolaryngology providers from July 2014 to March 2022 were analyzed. Surveys were categorized by child (<18 years old) or adult and consisted of 14 items including 6 service domains of access, visit, nursing, provider, personal issues, and assessment. Analysis was performed with Walsh's <i>t</i> test and analysis of variance. Multivariable logistic regression, controlling for wait times and provider, evaluated the likelihood of highest satisfaction scores (HI-SCORES) based on age.</p><p><strong>Results: </strong>A total of 2549 patients (135 pediatric, 2414 adults) completed the PGS on their initial visit. There was no significant difference in the mean overall satisfaction scores between pediatric and adult patients. Further analysis of service domains among pediatric patients found the mean score in the access domain to be higher for the 6- to 11-year-old age group (0-5 years old: 85.5 ± 20.5 [mean ± SD], 6-11 years old: 94.7 ± 11.5, 12-17 years old: 87.3 ± 15.4, <i>P</i> = .03). Pediatric patients did not have a significantly higher likelihood (odds ratio = 1.1, 95% confidence interval: 0.8-1.6, <i>P</i> > .05) of reporting HI-SCORES compared to adults after covariate adjustment.</p><p><strong>Conclusion: </strong>There was no significant difference in patient satisfaction scores for providers who treat pediatric and adult patients utilizing the same facility and scheduling team.</p>","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"8 2","pages":"e141"},"PeriodicalIF":1.5,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11066763/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140867845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-30eCollection Date: 2024-04-01DOI: 10.1002/oto2.142
Derek Sheen, Thomas K Houser, Sofia E Olsson, Helene Dabbous, Yann-Fuu Kou, Romaine F Johnson, Stephen R Chorney
Objective: To determine whether injection laryngoplasty (IL) resolves thin liquid aspiration among children with unilateral vocal cord paralysis (UVCP) after cardiac surgery.
Study design: Retrospective case-control.
Setting: Tertiary children's hospital.
Methods: Consecutive children (<5 years) between 2012 and 2022 with UVCP after cardiac surgery were included. Resolution of thin liquid aspiration after IL versus observation was determined for children obtaining videofluoroscopic swallow studies (VFSS).
Results: A total of 32 children with left UVCP after cardiac surgery met inclusion. Initial surgeries were N = 9 (28%) patent ductus arteriosus ligations, N = 7 (22%) aortic arch surgeries, N = 9 (28%) surgeries for hypoplastic left heart syndrome, and N = 7 (22%) other cardiac surgeries. The mean age at initial surgery was 1.8 months (SD: 3.7). All children had a VFSS obtained after surgery that confirmed aspiration. There were 17 children that obtained an IL at 33.6 months (SD: 20.9) after cardiac surgery and 15 children observed without IL procedure. No surgical complications after IL were noted. The rate of aspiration resolution based on postoperative VFSS was N = 14 (82%) for the IL group and N = 9 (60%) for the control group P = .24. Documented VFSS aspiration resolution after cardiac surgery occurred by 9.6 months (SD: 10.0) in the observation group and 47.4 months (SD: 24.1) in the IL group (P < .001).
Conclusion: IL can help treat aspiration in children with UVCP after cardiac surgery but the benefit beyond observation remains unclear. Future studies should continue to explore the utility for IL in managing dysphagia in this pediatric population.
研究目的研究设计:回顾性病例对照:研究设计:回顾性病例对照:研究设计:回顾性病例对照:方法:连续收治患儿(结果:共有 32 名左侧声带麻痹患儿接受了心脏手术):结果:共有32名心脏手术后左侧UVCP患儿符合纳入条件。初次手术包括N=9(28%)次动脉导管未闭结扎手术、N=7(22%)次主动脉弓手术、N=9(28%)次左心功能不全综合征手术以及N=7(22%)次其他心脏手术。首次手术的平均年龄为 1.8 个月(标清:3.7)。所有患儿均在术后获得了确认吸入的 VFSS。17名患儿在心脏手术后33.6个月(SD:20.9)时进行了IL,15名患儿未进行IL手术。IL术后未发现手术并发症。根据术后 VFSS,IL 组吸入缓解率为 N = 14(82%),对照组为 N = 9(60%),P = .24。观察组在心脏手术后 9.6 个月(SD:10.0)内 VFSS 吸入症状明显缓解,IL 组在 47.4 个月(SD:24.1)内 VFSS 吸入症状明显缓解:IL 可帮助治疗心脏手术后 UVCP 患儿的吸入,但观察之外的益处仍不明确。未来的研究应继续探索 IL 在治疗此类儿童吞咽困难方面的作用。
{"title":"Injection Laryngoplasty for Children with Dysphagia after Cardiac Surgery.","authors":"Derek Sheen, Thomas K Houser, Sofia E Olsson, Helene Dabbous, Yann-Fuu Kou, Romaine F Johnson, Stephen R Chorney","doi":"10.1002/oto2.142","DOIUrl":"https://doi.org/10.1002/oto2.142","url":null,"abstract":"<p><strong>Objective: </strong>To determine whether injection laryngoplasty (IL) resolves thin liquid aspiration among children with unilateral vocal cord paralysis (UVCP) after cardiac surgery.</p><p><strong>Study design: </strong>Retrospective case-control.</p><p><strong>Setting: </strong>Tertiary children's hospital.</p><p><strong>Methods: </strong>Consecutive children (<5 years) between 2012 and 2022 with UVCP after cardiac surgery were included. Resolution of thin liquid aspiration after IL versus observation was determined for children obtaining videofluoroscopic swallow studies (VFSS).</p><p><strong>Results: </strong>A total of 32 children with left UVCP after cardiac surgery met inclusion. Initial surgeries were N = 9 (28%) patent ductus arteriosus ligations, N = 7 (22%) aortic arch surgeries, N = 9 (28%) surgeries for hypoplastic left heart syndrome, and N = 7 (22%) other cardiac surgeries. The mean age at initial surgery was 1.8 months (SD: 3.7). All children had a VFSS obtained after surgery that confirmed aspiration. There were 17 children that obtained an IL at 33.6 months (SD: 20.9) after cardiac surgery and 15 children observed without IL procedure. No surgical complications after IL were noted. The rate of aspiration resolution based on postoperative VFSS was N = 14 (82%) for the IL group and N = 9 (60%) for the control group <i>P</i> = .24. Documented VFSS aspiration resolution after cardiac surgery occurred by 9.6 months (SD: 10.0) in the observation group and 47.4 months (SD: 24.1) in the IL group (<i>P</i> < .001).</p><p><strong>Conclusion: </strong>IL can help treat aspiration in children with UVCP after cardiac surgery but the benefit beyond observation remains unclear. Future studies should continue to explore the utility for IL in managing dysphagia in this pediatric population.</p>","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"8 2","pages":"e142"},"PeriodicalIF":1.5,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11058695/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140857427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-26eCollection Date: 2024-04-01DOI: 10.1002/oto2.140
Caden D Duffy, Madeleine E Gallagher, Paul W Bauer, Maxie D Brewer
{"title":"Inferior Turbinate Abscess from Bulb Suctioning in a Pediatric Patient.","authors":"Caden D Duffy, Madeleine E Gallagher, Paul W Bauer, Maxie D Brewer","doi":"10.1002/oto2.140","DOIUrl":"https://doi.org/10.1002/oto2.140","url":null,"abstract":"","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"8 2","pages":"e140"},"PeriodicalIF":1.5,"publicationDate":"2024-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11048040/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140852281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-19eCollection Date: 2024-01-01DOI: 10.1002/oto2.118
Oluwatobiloba Ayo-Ajibola, Ryan J Davis, Claire Theriault, Christopher Lamb, Deborah Choe, Matthew E Lin, Trevor E Angell, Daniel I Kwon
Objective: To understand the quality of informational Graves' disease (GD) videos on YouTube for treatment decision-making quality and inclusion of American Thyroid Association (ATA) treatment guidelines.
Study design: Cross-sectional cohort.
Setting: Informational YouTube videos with subject matter "Graves' Disease treatment."
Method: The top 50 videos based on our query were assessed using the DISCERN instrument. This validated algorithm discretely rates treatment-related information from excellent (≥4.5) to very poor (<1.9). Videos were also screened for ATA guideline inclusion. Descriptive statistics were used for cohort characterization. Univariate and multivariate linear regressions characterized factors associated with DISCERN scores. Significance was set at P < .05.
Results: The videos featured 57,513.43 views (SD = 162,579.25), 1054.70 likes (SD = 2329.77), and 168.80 comments (SD = 292.97). Most were patient education (52%) or patient experience (24%). A minority (40%) were made by thyroid specialists (endocrinologists, endocrine surgeons, or otolaryngologists). Under half did not mention all 3 treatment modalities (44%), and 54% did not mention any ATA recommendations. Overall, videos displayed poor reliability (mean = 2.26, SD = 0.67), treatment information quality (mean = 2.29, SD = 0.75), and overall video quality (mean = 2.47, SD = 1.07). Physician videos were associated with lower likes, views, and comments (P < .001) but higher DISCERN reliability (P = .015) and overall score (P = .019). Longer videos (P = .015), patient accounts (P = .013), and patient experience (P = .002) were associated with lower scores.
Conclusion: The most available GD treatment content on YouTube varies significantly in the quality of medical information. This may contribute to suboptimal disease understanding, especially for patients highly engaged with online health information sources.
{"title":"Evaluation of YouTube As A Source For Graves' Disease Information: Is High-Quality Guideline-Based Information Available?","authors":"Oluwatobiloba Ayo-Ajibola, Ryan J Davis, Claire Theriault, Christopher Lamb, Deborah Choe, Matthew E Lin, Trevor E Angell, Daniel I Kwon","doi":"10.1002/oto2.118","DOIUrl":"https://doi.org/10.1002/oto2.118","url":null,"abstract":"<p><strong>Objective: </strong>To understand the quality of informational Graves' disease (GD) videos on YouTube for treatment decision-making quality and inclusion of American Thyroid Association (ATA) treatment guidelines.</p><p><strong>Study design: </strong>Cross-sectional cohort.</p><p><strong>Setting: </strong>Informational YouTube videos with subject matter \"Graves' Disease treatment.\"</p><p><strong>Method: </strong>The top 50 videos based on our query were assessed using the DISCERN instrument. This validated algorithm discretely rates treatment-related information from excellent (≥4.5) to very poor (<1.9). Videos were also screened for ATA guideline inclusion. Descriptive statistics were used for cohort characterization. Univariate and multivariate linear regressions characterized factors associated with DISCERN scores. Significance was set at <i>P</i> < .05.</p><p><strong>Results: </strong>The videos featured 57,513.43 views (SD = 162,579.25), 1054.70 likes (SD = 2329.77), and 168.80 comments (SD = 292.97). Most were patient education (52%) or patient experience (24%). A minority (40%) were made by thyroid specialists (endocrinologists, endocrine surgeons, or otolaryngologists). Under half did not mention all 3 treatment modalities (44%), and 54% did not mention any ATA recommendations. Overall, videos displayed poor reliability (mean = 2.26, SD = 0.67), treatment information quality (mean = 2.29, SD = 0.75), and overall video quality (mean = 2.47, SD = 1.07). Physician videos were associated with lower likes, views, and comments (<i>P</i> < .001) but higher DISCERN reliability (<i>P</i> = .015) and overall score (<i>P</i> = .019). Longer videos (<i>P</i> = .015), patient accounts (<i>P</i> = .013), and patient experience (<i>P</i> = .002) were associated with lower scores.</p><p><strong>Conclusion: </strong>The most available GD treatment content on YouTube varies significantly in the quality of medical information. This may contribute to suboptimal disease understanding, especially for patients highly engaged with online health information sources.</p>","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"8 1","pages":"e118"},"PeriodicalIF":1.5,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10949313/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140175795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-15eCollection Date: 2024-01-01DOI: 10.1002/oto2.124
Alan W Wang, Evan A Patel, Nina Patel, Trevor A Poulson, Ashok A Jagasia
Our objectives were to quantify geographical disparities in otolaryngology care access with respect to American Indian (AI) populations and to identify gaps in care. Although increased incidence and mortality rates of ear, nose, and throat (ENT) conditions in AI populations are well documented, few studies address factors contributing to these differential outcomes. We conducted a cross-sectional study of US states with AI areas that either met the population threshold for the American Community Survey annual estimate or annual supplemental estimate. A 2-tailed t test was used to compare the geographic distribution of ENT providers practicing within AI areas against non-AI areas, showing a statistically significant difference (P < .001) in the concentration of providers (0.409 vs 2.233 providers per 100,000 patients). To our knowledge, this is the first study to explore geographic barriers contributing to AI disparities within otolaryngology.
我们的目标是量化美国印第安人(AI)在获得耳鼻喉科医疗服务方面的地域差异,并找出医疗服务中的差距。尽管耳鼻喉科(ENT)疾病在美国印第安人中的发病率和死亡率都有所提高,但很少有研究涉及导致这些差异结果的因素。我们对美国各州的人工智能地区进行了一项横断面研究,这些地区的人口数量达到了美国社区调查年度估计值或年度补充估计值的阈值。我们使用双尾 t 检验比较了在人工智能地区和非人工智能地区执业的耳鼻喉科医疗人员的地理分布,结果显示两者之间存在显著的统计学差异(P<0.05)。
{"title":"Otolaryngology Care Disparities in American Indian Populations.","authors":"Alan W Wang, Evan A Patel, Nina Patel, Trevor A Poulson, Ashok A Jagasia","doi":"10.1002/oto2.124","DOIUrl":"10.1002/oto2.124","url":null,"abstract":"<p><p>Our objectives were to quantify geographical disparities in otolaryngology care access with respect to American Indian (AI) populations and to identify gaps in care. Although increased incidence and mortality rates of ear, nose, and throat (ENT) conditions in AI populations are well documented, few studies address factors contributing to these differential outcomes. We conducted a cross-sectional study of US states with AI areas that either met the population threshold for the American Community Survey annual estimate or annual supplemental estimate. A 2-tailed <i>t</i> test was used to compare the geographic distribution of ENT providers practicing within AI areas against non-AI areas, showing a statistically significant difference (<i>P</i> < .001) in the concentration of providers (0.409 vs 2.233 providers per 100,000 patients). To our knowledge, this is the first study to explore geographic barriers contributing to AI disparities within otolaryngology.</p>","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"8 1","pages":"e124"},"PeriodicalIF":1.5,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10941493/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140143932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-14eCollection Date: 2024-01-01DOI: 10.1002/oto2.123
Tyler J Gallagher, Meredith E Adams, Janet S Choi
This study investigated management practices for Meniere's disease (MD) and their temporal trends from 2008 to 2022 within the TriNetX network database. Study cohort included adult patients (≥18 years) with the diagnosis of MD from TriNetX's multi-institutional medical records (n = 77,493). MD diagnosis and management were queried based on the international classification of diseases, tenth revision, current procedural terminology, and RXNorm codes. Temporal trends were analyzed using joinpoint regression. There was significant increase in rates of relevant medications prescribed within 12 months of MD diagnosis from 2008 to 2022 (annual percent change [APC]: 1.2 [95% confidence interval, CI: 0.4-1.9]). There were no significant changes in rate of intratympanic injection within 12 months of MD diagnosis (1.7 [95% CI: -1.1 to 4.5]). Rate of endolymphatic sac surgery and labyrinthectomy any time after MD diagnosis gradually decreased from 2008 to 2022 at APC of -8.1 (95% CI: -11.8 to -4.2) and -11.0 (95% CI: -14.0 to -7.7), respectively. Use of relevant medications has significantly increased during the early management of MD and the overall use of surgical treatments has decreased.
{"title":"Trends in Management of Ménière Disease: A TriNetX Network Database Analysis.","authors":"Tyler J Gallagher, Meredith E Adams, Janet S Choi","doi":"10.1002/oto2.123","DOIUrl":"10.1002/oto2.123","url":null,"abstract":"<p><p>This study investigated management practices for Meniere's disease (MD) and their temporal trends from 2008 to 2022 within the TriNetX network database. Study cohort included adult patients (≥18 years) with the diagnosis of MD from TriNetX's multi-institutional medical records (n = 77,493). MD diagnosis and management were queried based on the international classification of diseases, tenth revision, current procedural terminology, and RXNorm codes. Temporal trends were analyzed using joinpoint regression. There was significant increase in rates of relevant medications prescribed within 12 months of MD diagnosis from 2008 to 2022 (annual percent change [APC]: 1.2 [95% confidence interval, CI: 0.4-1.9]). There were no significant changes in rate of intratympanic injection within 12 months of MD diagnosis (1.7 [95% CI: -1.1 to 4.5]). Rate of endolymphatic sac surgery and labyrinthectomy any time after MD diagnosis gradually decreased from 2008 to 2022 at APC of -8.1 (95% CI: -11.8 to -4.2) and -11.0 (95% CI: -14.0 to -7.7), respectively. Use of relevant medications has significantly increased during the early management of MD and the overall use of surgical treatments has decreased.</p>","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"8 1","pages":"e123"},"PeriodicalIF":1.5,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10938781/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140132258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-10eCollection Date: 2024-01-01DOI: 10.1002/oto2.122
Hiroatsu Hatsukawa, Masaaki Ishikawa
Objective: Machine learning methods using regression models can predict actual values of histological eosinophil count from blood eosinophil levels. Therefore, these methods might be useful for diagnosing eosinophilic chronic rhinosinusitis, but their utility still remains unclear. We compared 2 statistical approaches, and investigated the utility of machine learning methods for diagnosing eosinophilic chronic rhinosinusitis.
Study design: Retrospective study.
Setting: Medical center.
Methods: Data, including eosinophilic levels, obtained from blood and sinonasal samples of 264 patients with chronic rhinosinusitis (257 with and 57 without nasal polyps) were analyzed. We determined factors affecting histopathological eosinophil count in regression models. We also investigated optimal cutoff values for blood eosinophil percentages/absolute eosinophil counts (AECs) through receiver operating characteristic curves and machine-learning methods based on regression models. A histopathological eosinophil count ≥10/high-power field was defined as eosinophilic chronic rhinosinusitis.
Results: Blood eosinophil levels, nasal polyp presence, and comorbid asthma were factors affecting histopathological eosinophil count. Cutoffs between the 2 statistical approaches differed in the group with nasal polyps, but not in one without nasal polyps. Machine-learning methods identified blood eosinophil percentages ≥1% or AEC ≥100/μL as cut-offs for eosinophilic chronic rhinosinusitis with nasal polyps, while ≥6% or ≥400/μL for one without nasal polyps.
Conclusion: Cut-offs of blood eosinophil levels obtained by machine-learning methods might be useful when suspecting eosinophilic chronic rhinosinusitis prior to biopsy because of their ability to adjust covariates, dealing with overfitting, and predicting actual values of histological eosinophil count.
{"title":"Clinical Utility of Machine Learning Methods Using Regression Models for Diagnosing Eosinophilic Chronic Rhinosinusitis.","authors":"Hiroatsu Hatsukawa, Masaaki Ishikawa","doi":"10.1002/oto2.122","DOIUrl":"10.1002/oto2.122","url":null,"abstract":"<p><strong>Objective: </strong>Machine learning methods using regression models can predict actual values of histological eosinophil count from blood eosinophil levels. Therefore, these methods might be useful for diagnosing eosinophilic chronic rhinosinusitis, but their utility still remains unclear. We compared 2 statistical approaches, and investigated the utility of machine learning methods for diagnosing eosinophilic chronic rhinosinusitis.</p><p><strong>Study design: </strong>Retrospective study.</p><p><strong>Setting: </strong>Medical center.</p><p><strong>Methods: </strong>Data, including eosinophilic levels, obtained from blood and sinonasal samples of 264 patients with chronic rhinosinusitis (257 with and 57 without nasal polyps) were analyzed. We determined factors affecting histopathological eosinophil count in regression models. We also investigated optimal cutoff values for blood eosinophil percentages/absolute eosinophil counts (AECs) through receiver operating characteristic curves and machine-learning methods based on regression models. A histopathological eosinophil count ≥10/high-power field was defined as eosinophilic chronic rhinosinusitis.</p><p><strong>Results: </strong>Blood eosinophil levels, nasal polyp presence, and comorbid asthma were factors affecting histopathological eosinophil count. Cutoffs between the 2 statistical approaches differed in the group with nasal polyps, but not in one without nasal polyps. Machine-learning methods identified blood eosinophil percentages ≥1% or AEC ≥100/μL as cut-offs for eosinophilic chronic rhinosinusitis with nasal polyps, while ≥6% or ≥400/μL for one without nasal polyps.</p><p><strong>Conclusion: </strong>Cut-offs of blood eosinophil levels obtained by machine-learning methods might be useful when suspecting eosinophilic chronic rhinosinusitis prior to biopsy because of their ability to adjust covariates, dealing with overfitting, and predicting actual values of histological eosinophil count.</p>","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"8 1","pages":"e122"},"PeriodicalIF":1.5,"publicationDate":"2024-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10924764/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140094404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: This study aimed to investigate the clinical features of long COVID cases presenting with upper respiratory symptoms, a topic not yet fully elucidated.
Study design: Prospective cohort study.
Setting: A multicenter study involving 26 medical facilities in Japan.
Methods: Inclusion criteria were patients aged ≥18 years old with a confirmed COVID-19 diagnosis via severe acute respiratory syndrome coronavirus 2 polymerase chain reaction or antigen testing, who were hospitalized at the participating medical facilities. Analyzing clinical information and patient-reported outcomes from 1009 patients were analyzed. The outcome measured the degree of initial symptoms for taste or olfactory disorders and assessed the likelihood of these symptoms persisting as long COVID, as well as the impact on quality of life if the upper respiratory symptoms persisted as long COVID.
Results: Patients with high albumin, low C-reactive protein, and low lactate dehydrogenase in laboratory tests tended to experience taste or olfactory disorders as part of long COVID. Those with severe initial symptoms had a higher risk of experiencing residual symptoms at 3 months, with an odds ratio of 2.933 (95% confidence interval [CI], 1.282-6.526) for taste disorders and 3.534 (95% CI, 1.382-9.009) for olfactory disorders. Presence of upper respiratory symptoms consistently resulted in lower quality of life scores.
Conclusion: The findings from this cohort study suggest that severe taste or olfactory disorders as early COVID-19 symptoms correlate with an increased likelihood of persistent symptoms in those disorders as long COVID.
{"title":"Upper Respiratory Symptoms as Long COVID: Insight from a Multicenter Cohort Study.","authors":"Masahiko Okada, Noriyuki Ishida, Sho Kanzaki, Ichiro Kawada, Kengo Nagashima, Hideki Terai, Gaku Hiruma, Ho Namkoong, Takanori Asakura, Katsunori Masaki, Keiko Ohgino, Jun Miyata, Shotaro Chubachi, Nobuhiro Kodama, Shunsuke Maeda, Satoshi Sakamoto, Masaki Okamoto, Yoji Nagasaki, Akira Umeda, Kazuya Miyagawa, Hisato Shimada, Kazuhiro Minami, Rie Hagiwara, Makoto Ishii, Yasunori Sato, Koichi Fukunaga","doi":"10.1002/oto2.120","DOIUrl":"10.1002/oto2.120","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the clinical features of long COVID cases presenting with upper respiratory symptoms, a topic not yet fully elucidated.</p><p><strong>Study design: </strong>Prospective cohort study.</p><p><strong>Setting: </strong>A multicenter study involving 26 medical facilities in Japan.</p><p><strong>Methods: </strong>Inclusion criteria were patients aged ≥18 years old with a confirmed COVID-19 diagnosis via severe acute respiratory syndrome coronavirus 2 polymerase chain reaction or antigen testing, who were hospitalized at the participating medical facilities. Analyzing clinical information and patient-reported outcomes from 1009 patients were analyzed. The outcome measured the degree of initial symptoms for taste or olfactory disorders and assessed the likelihood of these symptoms persisting as long COVID, as well as the impact on quality of life if the upper respiratory symptoms persisted as long COVID.</p><p><strong>Results: </strong>Patients with high albumin, low C-reactive protein, and low lactate dehydrogenase in laboratory tests tended to experience taste or olfactory disorders as part of long COVID. Those with severe initial symptoms had a higher risk of experiencing residual symptoms at 3 months, with an odds ratio of 2.933 (95% confidence interval [CI], 1.282-6.526) for taste disorders and 3.534 (95% CI, 1.382-9.009) for olfactory disorders. Presence of upper respiratory symptoms consistently resulted in lower quality of life scores.</p><p><strong>Conclusion: </strong>The findings from this cohort study suggest that severe taste or olfactory disorders as early COVID-19 symptoms correlate with an increased likelihood of persistent symptoms in those disorders as long COVID.</p>","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"8 1","pages":"e120"},"PeriodicalIF":1.5,"publicationDate":"2024-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10909391/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140022289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-28eCollection Date: 2024-01-01DOI: 10.1002/oto2.121
Wasiq Nadeem, Jay K Ferrell, Christine B Taylor
{"title":"Peronea Magna: An Important Anatomic Variant Impacting Fibula-Free Flap Reconstruction.","authors":"Wasiq Nadeem, Jay K Ferrell, Christine B Taylor","doi":"10.1002/oto2.121","DOIUrl":"10.1002/oto2.121","url":null,"abstract":"","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"8 1","pages":"e121"},"PeriodicalIF":1.5,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10900915/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139990834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-28eCollection Date: 2024-01-01DOI: 10.1002/oto2.117
Matthew Awad, Ibrahim Abdalla, Sebastian M Jara, Tina C Huang, Meredith E Adams, Janet S Choi
Objective: The impact of poor sleep on tinnitus has been mainly attributed to central processes. There is an association between sleep disorders and hearing loss, but whether hearing levels mediate the association between sleep disorders and tinnitus is unknown. This study investigates the association between sleep characteristics, tinnitus, and hearing loss.
Study design: Cross-sectional.
Setting: National Health and Nutrition Examination Survey (NHANES).
Methods: Study cohort includes 9693 adults (≥20 years) from the NHANES 2005 to 2018 who completed audiometric testing and questionnaires on tinnitus and sleep characteristics. Multivariable regression analyses were performed to quantify associations between sleep characteristics, tinnitus, and hearing loss.
Results: In this cohort, 29% (95% confidence interval [CI]: 28%-31%) reported trouble sleeping and 9% (95% CI: 8%-10%) reported being diagnosed with sleep disorders. Negative sleep characteristics (less hours of sleep, diagnosis of a sleep disorder, trouble sleeping, or OSA symptoms) were not associated with audiometry-measured hearing loss in multivariable models adjusted for demographics and comorbidities but were significantly associated with bothersome tinnitus. This association remained significant without substantial attenuation in multivariable models additionally adjusting for hearing levels: sleeping <8 h/day (vs ≥8) (odds ratio [OR]: 1.28 [95% CI: 1.08-1.52]), trouble sleeping (OR: 1.78 [95% CI: 1.45-2.19]), diagnosis of sleep disorders (OR: 1.57 [95% CI: 1.14-2.15]), and report of OSA symptoms (OR: 1.42 [95% CI: 1.08-1.88]).
Conclusion: Negative sleep characteristics were associated with tinnitus while there was no clinically meaningful association between sleep and hearing loss. Our findings suggest that the relationship between poor sleep and tinnitus is likely contributed by central processes without a major role of mediation via the peripheral auditory system.
目的:睡眠不足对耳鸣的影响主要归因于中枢过程。睡眠障碍与听力损失之间存在关联,但听力水平是否会介导睡眠障碍与耳鸣之间的关联尚不清楚。本研究调查了睡眠特征、耳鸣和听力损失之间的关系:研究设计:横断面:美国国家健康与营养调查(NHANES):研究队列包括2005年至2018年NHANES中的9693名成年人(≥20岁),他们完成了听力测试和有关耳鸣和睡眠特征的问卷调查。研究人员进行了多变量回归分析,以量化睡眠特征、耳鸣和听力损失之间的关联:在这组人群中,29%(95% 置信区间 [CI]:28%-31%)的人表示有睡眠问题,9%(95% 置信区间:8%-10%)的人表示被诊断患有睡眠障碍。在调整了人口统计学和合并症的多变量模型中,负面睡眠特征(睡眠时间少、被诊断患有睡眠障碍、睡眠困难或 OSA 症状)与听力测定法测量的听力损失无关,但与令人烦恼的耳鸣显著相关。在对听力水平进行额外调整的多变量模型中,这种相关性仍然显著,且没有大幅衰减:不良睡眠特征与耳鸣有关,而睡眠与听力损失之间没有临床意义上的关联。我们的研究结果表明,睡眠质量差与耳鸣之间的关系很可能是由中枢过程造成的,而外周听觉系统并没有发挥重要的中介作用。
{"title":"Association of Sleep Characteristics with Tinnitus and Hearing Loss.","authors":"Matthew Awad, Ibrahim Abdalla, Sebastian M Jara, Tina C Huang, Meredith E Adams, Janet S Choi","doi":"10.1002/oto2.117","DOIUrl":"10.1002/oto2.117","url":null,"abstract":"<p><strong>Objective: </strong>The impact of poor sleep on tinnitus has been mainly attributed to central processes. There is an association between sleep disorders and hearing loss, but whether hearing levels mediate the association between sleep disorders and tinnitus is unknown. This study investigates the association between sleep characteristics, tinnitus, and hearing loss.</p><p><strong>Study design: </strong>Cross-sectional.</p><p><strong>Setting: </strong>National Health and Nutrition Examination Survey (NHANES).</p><p><strong>Methods: </strong>Study cohort includes 9693 adults (≥20 years) from the NHANES 2005 to 2018 who completed audiometric testing and questionnaires on tinnitus and sleep characteristics. Multivariable regression analyses were performed to quantify associations between sleep characteristics, tinnitus, and hearing loss.</p><p><strong>Results: </strong>In this cohort, 29% (95% confidence interval [CI]: 28%-31%) reported trouble sleeping and 9% (95% CI: 8%-10%) reported being diagnosed with sleep disorders. Negative sleep characteristics (less hours of sleep, diagnosis of a sleep disorder, trouble sleeping, or OSA symptoms) were not associated with audiometry-measured hearing loss in multivariable models adjusted for demographics and comorbidities but were significantly associated with bothersome tinnitus. This association remained significant without substantial attenuation in multivariable models additionally adjusting for hearing levels: sleeping <8 h/day (vs ≥8) (odds ratio [OR]: 1.28 [95% CI: 1.08-1.52]), trouble sleeping (OR: 1.78 [95% CI: 1.45-2.19]), diagnosis of sleep disorders (OR: 1.57 [95% CI: 1.14-2.15]), and report of OSA symptoms (OR: 1.42 [95% CI: 1.08-1.88]).</p><p><strong>Conclusion: </strong>Negative sleep characteristics were associated with tinnitus while there was no clinically meaningful association between sleep and hearing loss. Our findings suggest that the relationship between poor sleep and tinnitus is likely contributed by central processes without a major role of mediation via the peripheral auditory system.</p>","PeriodicalId":19697,"journal":{"name":"OTO Open","volume":"8 1","pages":"e117"},"PeriodicalIF":1.5,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10900921/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139990833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}