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SOME INNOVATIVE TECHNOLOGIES FOR THE CORRECTION OF VALVULAR HEART DISEASES. REVIEW 心脏瓣膜病矫治的一些创新技术。审查
Pub Date : 2021-10-01 DOI: 10.35805/bsk2021iv022
I. Sagatov, A. Kudaibergen, B. Momynov
Valve defects or congenital/acquired heart defects are damage to the valve and/or subvalvular structures, which leads to impaired hemodynamics and the development of heart failure. Asymptomatic valvular heart disease is present in 2.5% of the population; with age, this figure rises to 13%. In the absence of permanent treatment, lesions of the heart valves significantly reduce the quality and duration of life. The European Society of Cardiology (ESC) and the American Heart Association (AHA) regularly review the effectiveness of new surgical treatments and reflect their findings in international guidelines. Today, minimally invasive surgery is the most effective and safe way to treat patients with valvular heart disease. The article presents two new methods for the treatment of valvular heart disease. Transapical mitral valve repair on a beating heart with neochord implantation (TOP-MINI) is a new MVP option that has been approved for patients with severe mitral regurgitation due to prolapse of the leaflet (s) or chord (grades 2-4). The new procedure with the NeoChord DS1000 device results in a significant reduction in mitral regurgitation and in reverse remodeling of the left ventricle and left atrium after 6 months of follow-up. Also reviewed is Minimally Invasive Aortic Valve Replacement (MAVR), which has been shown to be beneficial in improving patient satisfaction by minimizing pain and earlier recovery. Sutureless valves are preferred over traditional aortic valve replacement (AVR) due to the reduced operation time and the need for blood transfusion. The Perceval valve (Sorin, Sallugia, Italy) is a self-expanding bovine pericardial prosthesis placed in a nitinol stent designed to facilitate aortic valve implantation. A systematic review and meta-analysis demonstrated that the early clinical and hemodynamic characteristics of the Perceval valve are satisfactory and comparable to those of conventional AVRs. This literature review was carried out in accordance with the PRISM statement. The databases searched in this review included Pubmed, Web of Science, Scopus and Cochrane databases for systematic reviews
瓣膜缺损或先天性/获得性心脏缺损是对瓣膜和/或瓣下结构的损害,导致血流动力学受损和心力衰竭的发展。2.5%的人口存在无症状的瓣膜性心脏病;随着年龄的增长,这个数字上升到13%。在没有永久性治疗的情况下,心脏瓣膜病变会显著降低生活质量和持续时间。欧洲心脏病学会(ESC)和美国心脏协会(AHA)定期审查新手术治疗的有效性,并将他们的发现反映在国际指南中。如今,微创手术是治疗瓣膜性心脏病患者最有效、最安全的方法。本文介绍了治疗瓣膜性心脏病的两种新方法。经尖顶二尖瓣修复与新脐带植入跳动的心脏(TOP-MINI)是一个新的MVP选择,已被批准用于严重的二尖瓣反流患者由于小叶(s)或弦脱垂(2-4级)。在6个月的随访后,使用NeoChord DS1000装置的新手术显著减少了二尖瓣反流,并使左心室和左心房的反向重塑。此外,微创主动脉瓣置换术(MAVR)已被证明可以通过减少疼痛和早期恢复来提高患者满意度。无缝线瓣膜比传统的主动脉瓣置换术(AVR)更受欢迎,因为它减少了手术时间和输血的需要。Perceval瓣膜(Sorin, salugia, Italy)是一种自膨胀的牛心包假体,放置在镍钛合金支架中,旨在促进主动脉瓣植入。一项系统回顾和荟萃分析表明,Perceval瓣膜的早期临床和血流动力学特征是令人满意的,与传统的avr相当。本文献综述按照PRISM声明进行。本综述检索的数据库包括Pubmed、Web of Science、Scopus和Cochrane等系统综述数据库
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引用次数: 0
MODERN PRINCIPLES OF DIAGNOSIS AND SURGICAL TREATMENT OF ISCHEMIC MITRAL INSUFFICIENCY 缺血性二尖瓣功能不全的现代诊断和外科治疗原则
Pub Date : 2021-10-01 DOI: 10.35805/bsk2021iv011
R. Mahmudov
The purpose of the study is to evaluate and analyze the results of surgical treatment of patients with ischemic mitral insufficiency. Material and methods. The results of the examination and surgical treatment of 35 patients with ischemic mitral insufficiency are analyzed. In the operative period, in order to identify the degree of mitral insufficiency and the valvular apparatus, an echocardiography was performed, where the diameter of the fibrous ring, the interpapillary distance, the annulopapillary distance, the area of the cusp tension, and the depth of the coaptation of the valves were determined. Results. A preoperative examination proved the presence of mitral valve insufficiency with regurgitation of varying degrees. 15 patients underwent myocardial revascularization, 20 patients underwent myocardial revascularization + various options for correction of ischemic mitral insufficiency. After the operation, a significant improvement in the spatial-geometric correlation of the LV and mitral valve by reducing the tension forces acting on the valves and in the group of patients undergoing myocardial revascularization + various options for the correction of ischemic mitral insufficiency as the elimination of regurgitation. Conclusion. In patients with ischemic heart disease after echocardiographic studies, having determined the degree of mitral insufficiency with its moderate and severe degree, it is necessary to have a surgical correction of the mitral valve in its apparatus; the use of myocardial revascularization + various options for the correction of ischemic mitral insufficiency gives more tantalizing results than isolated myocardial revascularization.
本研究的目的是评价和分析手术治疗缺血性二尖瓣功能不全患者的结果。材料和方法。分析35例缺血性二尖瓣功能不全患者的检查和手术治疗结果。在手术期间,为了确定二尖瓣功能不全的程度和瓣器,进行了超声心动图检查,其中确定了纤维环的直径,乳头间距离,环乳头距离,尖瓣张力面积和瓣合的深度。结果。术前检查证实存在二尖瓣功能不全并有不同程度的反流。15例患者行心肌血运重建术,20例患者行心肌血运重建术+各种方案校正缺血性二尖瓣功能不全。术后通过降低作用在瓣膜上的张力显著改善左室和二尖瓣的空间-几何相关性,在心肌血运重建术组+多种方案校正缺血性二尖瓣功能不全以消除返流。结论。缺血性心脏病患者经超声心动图检查,确定二尖瓣功能不全的程度,分为中度和重度,有必要对二尖瓣的脏器进行手术矫正;心肌血运重建术+多种治疗方案对缺血性二尖瓣功能不全的矫正效果比单纯心肌血运重建术更诱人。
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引用次数: 1
GASTRIN IN SERUM AND MORPHOLOGICAL STATE OF GASTRIN-SECRETING CELLS IN PATIENTS WITH GASTRIC POLYPOSIS 胃息肉病患者血清胃泌素及胃泌素分泌细胞形态变化
Pub Date : 2021-10-01 DOI: 10.35805/bsk2021iv038
R. Tazhimuradov, Maria Saranova, Rustam Madalihodjayev
Objective. Numerous studies regarding gastric hormones and their regulation have been performed until now. However, the effect of the hormones on the formation and malignisation of gastric polyps still remains not clear. Our aim was to identify the relation between the level of gastrin in the blood, gastric mucosa, polyp tissue, gastric juice and pathogenesis of gastric polyposis. Materials and methods. A thorough investigation of gastrointestinal hormones in serum and gastric juice, in polyp’s tissue and mucosa, gastrin-secreting cells and proteolytic activity of gastric juice was carried out in 40 patients with gastric polyps. These patients were divided into groups, depending on the location, number, and malignancy of the polyps. As a control group, 10 healthy individuals were used to determine the normal values of the studied indicators. Results: A significant increase (more than two times) in the gastrinemia level before the surgery was noted in patients with polyp recurrence, and gastrin level increased to more significant digits of 227.0+37.4 pg/ml (p<0.05) in one year after polypectomy. Conclusion. Gastrin is apparently involved in the process of polyp formation since polyp’s growth is accompanied by elevation of serum gastrin. This is confirmed by a response of gastrin in the blood to a test meal in individuals with different duration of the disease: a marked increase in gastrinemia appears in patients suffering from gastric polyposis for more than three years. Therefore, evaluation of gastrin level in the patients’ blood can be used to predict a recurrence potential of polyps. This is evidenced by more pronounced hypergastrinemia before polypectomy in patients who had a further recurrence of the disease within one year after the surgery
目标。迄今为止,人们对胃激素及其调控进行了大量的研究。然而,这些激素在胃息肉形成和恶性化中的作用尚不清楚。我们的目的是确定胃泌素在血液、胃粘膜、息肉组织、胃液中的水平与胃息肉病的发病机制之间的关系。材料和方法。本文对40例胃息肉患者的血清和胃液、息肉组织和粘膜、胃泌素分泌细胞及胃液的蛋白水解活性进行了深入的研究。根据息肉的位置、数量和恶性程度,这些患者被分为不同的组。选取10名健康个体作为对照组,测定各项指标的正常值。结果:息肉复发患者术前胃泌素水平明显升高(2倍以上),息肉切除术后1年胃泌素水平升高至227.0+37.4 pg/ml (p<0.05)。结论。胃泌素显然参与了息肉的形成过程,因为息肉的生长伴随着血清胃泌素的升高。在病程不同的个体中,血液中胃泌素对试验餐的反应证实了这一点:在患有胃息肉病超过三年的患者中,胃泌素血症明显增加。因此,评估患者血液中的胃泌素水平可用于预测息肉的复发潜力。息肉切除术后一年内复发的患者在息肉切除术前出现更明显的高胃泌素血症就是证据
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引用次数: 0
DE NOVO AUTOIMMUNE HEPATITIS AFTER LIVER TRANSPLANTATION IN CHILDREN. REVIEW 儿童肝移植后新发自身免疫性肝炎审查
Pub Date : 2021-10-01 DOI: 10.35805/bsk2021iv052
N. Yerimova, A. Akhbetova
De novo autoimmune hepatitis (AIH) is a clinical disease similar to AIH that develops in liver transplant recipients with diseases other than AIH. Timely recognition of this disease makes it possible to avoid graft rejection and liver re-transplantation (LT), liver fibrosis, and can ensure a long life expectancy, given the effectiveness of more active immunosuppression with the use of corticosteroids and azathioprine, as in the treatment of idiopathic AIH. The de novo prefix was added to distinguish this condition from primary autoimmune hepatitis prior to transplant, but the diagnostic algorithm adopted generally accepted diagnostic criteria for autoimmune hepatitis. In fact, de novo autoimmune hepatitis is characterized by typical necroinflammation of the liver, rich in plasma cells, increased serum gammaglobulin levels, and the appearance of inorganic specific autoantibodies. However, the general signs of autoimmune hepatitis de novo, apparently, cannot be associated with an unambiguous pathophysiological pathway, since they can develop in patients undergoing liver transplantation due to different etiologies. The literature review presents such aspects as the prevalence of this case, the influence of the HLA phenotype on the manifestation and outcome of the disease, diagnosis and treatment. Objective. To conduct a literary meta-analysis of scientific publications on the development of De novo Autoimmune hepatitis after liver transplantation in children. Materials and methods. The authors selected scientific bases for the search such as: Web of science, Cyberleninka, UpToDate, Pubmed and Cochrane, Google Scholar. Results. A meta-analysis of scientific articles in English and Russian was carried out for the selected keywords. The causes of development were not infectious or surgical complications. Liver biopsy revealed histological changes typical of acute or chronic ovulation. High levels of transaminases, hypergammaglobulinemia, positivity to autoantibodies – ANA, AMA, SMA, anti-LKM-1. De novo AIH patients did not respond to conventional anti-rejection therapy, but responded only to classical AIH therapy.
新生自身免疫性肝炎(De novo autoimmune hepatitis, AIH)是一种与AIH相似的临床疾病,发生在肝移植受者身上,并伴有AIH以外的疾病。及时发现这种疾病可以避免移植物排斥反应和肝再移植(LT)、肝纤维化,并且可以确保较长的预期寿命,因为在治疗特发性AIH时,使用皮质类固醇和硫唑嘌呤进行更积极的免疫抑制是有效的。添加de novo前缀是为了将这种情况与移植前的原发性自身免疫性肝炎区分开来,但诊断算法采用了普遍接受的自身免疫性肝炎诊断标准。事实上,新生自身免疫性肝炎的特征是典型的肝脏坏死性炎症,富含浆细胞,血清γ球蛋白水平升高,出现无机特异性自身抗体。然而,自身免疫性新生肝炎的一般症状显然不能与明确的病理生理途径相关联,因为它们可以在肝移植患者中由于不同的病因而发展。文献综述从本病例的流行情况、HLA表型对疾病表现和转归的影响、诊断和治疗等方面进行综述。目标。对儿童肝移植后发生自身免疫性肝炎的科学出版物进行文献荟萃分析。材料和方法。作者为搜索选择了科学基础,如:Web of science, Cyberleninka, UpToDate, Pubmed and Cochrane, Google Scholar。结果。对选取的关键词进行了英文和俄文科学文章的荟萃分析。发展的原因不是感染或手术并发症。肝活检显示急性或慢性排卵的典型组织学改变。转氨酶水平高,高γ球蛋白血症,自身抗体(ANA, AMA, SMA,抗lkm -1)阳性。新发AIH患者对常规抗排斥治疗无反应,但仅对经典AIH治疗有反应。
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引用次数: 0
DIRECT RESULTS OF CORONARY BYPASS GRAFTING OF PATIENTS WITH THE REDUCED MYOCARDIAL CONTRACTILITY IN TERMS OF MYOCARDIAL PERFUSION SCINTIGRAPHY AND ECHOCARDIOGRAPHY 冠脉搭桥术患者心肌收缩力降低的直接结果:心肌灌注显像和超声心动图
Pub Date : 2021-07-01 DOI: 10.35805/bsk2021iii005
A. Mansurov
This article provides an analysis of the results of surgical treatment of patients with various forms of coronary artery disease, the study of the quality and reliability of myocardial revascularization, assessment of patency and functional viability of coronary grafts in the early postoperative period using echocardiography and myocardial perfusion scintigraphy. The retrospective material of our study is based on the results of surgical treatment of 130 patients with coronary artery disease who were operated on in the IHD department over the past year. All patients underwent examination according to a standard protocol: electrocardiography, 24-hour Holter monitoring, selective coronary ventriculography and shuntography, echocardiography, perfusion scintigraphy before and after surgery, drug stress test to assess myocardial perfusion and contractility and its differentiation (ischemia, scarring) with hypoperfusion.
本文通过超声心动图和心肌灌注显像分析各种形式冠状动脉疾病患者的手术治疗结果,研究心肌血运重建的质量和可靠性,评估术后早期冠状动脉移植物的通畅性和功能活力。我们研究的回顾性资料是基于过去一年中在IHD科手术的130例冠状动脉疾病患者的手术治疗结果。所有患者均按标准方案进行检查:心电图、24小时动态心电图监测、选择性冠状室造影及分流术、超声心动图、术前术后灌注显像、药物应激试验评估心肌灌注、收缩力及其与低灌注的分化(缺血、瘢痕形成)。
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引用次数: 0
TYPES OF CORRECTION OF THE SUPRACARDIAC FORM OF PARTIAL ABNORMAL DRAINAGE OF THE PULMONARY VEINS. WARDEN PROCEDURE 心上型部分肺静脉异常引流的矫正类型。监狱长过程
Pub Date : 2021-07-01 DOI: 10.35805/bsk2021iii028
I. Sagatov, N. Dosmailov
The article describes the types of correction of the supracardial form of abnormal drainage of the pulmonary veins. One of the methods of correcting this defect is the Warden operation, which includes: after sternotomy, connection of artificial circulation, cardioplegia, the superior vena cava is cut off, the proximal end is sutured. Next, a right atriotomy is performed, an anastomosis is formed using an autopericardial patch between the abnormal drainage and the left atrium through the ASD. Then an anastomosis is formed between the auricle of the right atrium and the distal end of the superior vena cava. As a result, blood from the abnormal pulmonary veins begins to drain into the left atrium through the ASD.
本文介绍了肺静脉异常引流心包上型的矫正方法。矫正这一缺陷的方法之一是Warden手术,其包括:胸骨切开后,连接人工循环,心脏截流,切断上腔静脉,缝合近端。接下来,行右心房切开术,通过ASD在异常引流和左心房之间使用心包贴片形成吻合。然后在右心房耳廓和上腔静脉远端之间形成吻合。结果,来自异常肺静脉的血液开始通过ASD流入左心房。
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引用次数: 0
DAMAGE TO THE BILE DUCTS AFTER LAPAROSCOPIC CHOLECYSTECTOMY. REVIEW. 腹腔镜胆囊切除术后胆管损伤。审查。
Pub Date : 2021-07-01 DOI: 10.35805/bsk2021iii017
M. Doskhanov
This article provides a review of the literature on bile duct injuries after laparoscopic cholecystectomy. Laparascopy is considered the gold standard in the treatment of gallstone disease. This technique has a number of positive advantages: minimally invasiveness, quick rehabilitation, a shorter hospital stay, a good cosmetic effect, and a low lethal outcome. Along with these advantages, the number of complications also increased: damage to the bile ducts, hepatic vessels, bile leakage, formation of strictures, defects in drainage of the biliary tract and improper treatment of the cystic duct, insufficient drainage of the abdominal cavity.Today, many aspects of surgical treatment and prevention of bile duct injuries remain controversial and are still considered relevant. The main reasons for this complication are: lack of experience of the surgeon, inattention, ignorance of the main options and possible anomalies of important anatomical structures in the area of the hepatic hilum and hepato-duodenal ligament, technical errors.
本文就腹腔镜胆囊切除术后胆管损伤的相关文献进行综述。腹腔镜被认为是治疗胆结石疾病的金标准。这项技术有许多积极的优点:微创、快速康复、住院时间短、美容效果好、死亡率低。在这些优点的同时,并发症的数量也增加了:胆管、肝血管损伤、胆漏、狭窄形成、胆道引流缺陷及胆囊管处理不当、腹腔引流不足。今天,手术治疗和预防胆管损伤的许多方面仍然存在争议,但仍被认为是相关的。造成这种并发症的主要原因是:外科医生缺乏经验,注意力不集中,不知道主要的选择和肝门和肝十二指肠韧带区域重要解剖结构的可能异常,技术错误。
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引用次数: 1
GUNSHOT WOUND TO THE NECK WITH THROMBOSIS OF THE COMMON CAROTID ARTERY IN THE DELAYED PERIOD. (ANALYSIS OF CLINICAL OBSERVATION) 颈部枪伤伴有颈总动脉血栓形成。(临床观察分析)
Pub Date : 2021-07-01 DOI: 10.35805/bsk2021iii010
L. Kossovich, I. Kirillova
A case of non-penetrating neck injury with contusion and dissection of the common carotid artery with transition to the internal carotid artery is presented in a clinical observation. The clinical picture of the development of brain failure after thrombosis of the common and internal carotid arteries and regression of brain symptoms after reconstructive surgery is presented. A mathematical model of the lesion mechanism is analyzed separately. It is concluded that in case of a nonpenetrating wound of the neck with a traumatic weapon, the revision of the underlying tissues should be mandatory.
本文报道一例颈总动脉向颈内动脉过渡的非穿透性颈部损伤的临床观察。本文介绍了颈总动脉和颈内动脉血栓形成后脑功能衰竭发展的临床情况以及重建手术后脑症状的消退。对损伤机理的数学模型进行了分析。结论是,在颈部创伤性武器造成的非穿透性伤口的情况下,应强制对下层组织进行修正。
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引用次数: 0
SURGICAL TREATMENT OF ARTERIAL ANEURYSMS OF THE LOWER LIMB. 下肢动脉动脉瘤的外科治疗。
Pub Date : 2021-07-01 DOI: 10.35805/bsk2021iii032
M. Кhanchi, A. Matkerimov, A. Tergeussizov, T. Demeuov, A. Baubekov, M. Zhakubayev, T. Tajibayev, M. Khanchi, A. Shamshiev
Peripheral artery aneurysms are dangerous with possible complications such as ruptures, bleeding, thromboembolism in the distal bed with subsequent tissue ischemia, neurological disorders due to pressure of closely located nerve trunks. One of the most common causes of peripheral artery aneurysms is trauma. Special attention should be paid to a significant increase in the number of iatrogenic injuries. From 2000 to 2019, 46 patients were operated on the arteries of the lower extremities. Operations of various types of reconstructions were performed. The total age of the patients ranged from 30 to 76 years, the average age of the patients was 43.3± 6.5 years. A total of 6 (9.2%) patients were operated on with combined aneurysmal lesion of the femoral and popliteal arteries. In the postoperative period, 91.5% of patients with peripheral artery aneurysm had positive clinical results. 4 (8.5%) developed complications. Long-term results were tracked in the period from 3 months to 3 years. A clinical examination was performed, supplemented by ultrasound control. 2 cases of thrombosis in the distal anastomosis were identified, which were restored after reconstruction of the distal anastomosis.
外周动脉瘤是危险的,可能出现并发症,如破裂、出血、远端床血栓栓塞和随后的组织缺血,以及由于紧密定位的神经干压力引起的神经系统疾病。外周动脉瘤最常见的原因之一是外伤。应特别注意医源性损伤数量的显著增加。从2000年到2019年,46例患者接受了下肢动脉手术。进行了各种类型的重建操作。患者年龄30 ~ 76岁,平均43.3±6.5岁。股腘动脉合并动脉瘤病变6例(9.2%)行手术治疗。术后91.5%的外周动脉瘤患者临床结果为阳性。4例(8.5%)出现并发症。长期的研究结果从3个月到3年不等。进行临床检查,并辅以超声控制。发现2例远端吻合口血栓形成,重建远端吻合口后予以修复。
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引用次数: 0
RETROSPECTIVE ANALYSIS OF PATIENT REFERRALS FOR COMPUTED TOMOGRAPHY 计算机断层扫描患者的回顾性分析
Pub Date : 2018-12-31 DOI: 10.35805/KAZSURGERY.BSK.2018.4.5-7
D. Baiguisova, G. Kausova
To conduct a retrospective analysis of patient referrals for computed tomography to identify the main problems, both in writing the direction itself and in its validity. Materials and methods: The patient referrals for computed tomography (CT) were analyzed at the Radiology Department of the National Scientific Center named after AN Syzganov - outpatients for 3 months. Results and discussions: it has been established that, in the main, clinicians, when issuing a referral for a study, ignore such item as a diagnosis, or replace it with the word — examination. There is also the groundlessness and incorrectness of the referrals for the studies, considering their variability and insufficient awareness of doctors both in the indications and the need for a particular study. Conclusion: Clinicians are not sufficiently aware of the correctness of referrals for computed tomography and, as a result, write out incorrect referrals.
对转诊的计算机断层扫描患者进行回顾性分析,以确定主要问题,包括书写指示本身及其有效性。材料和方法:在AN Syzganov命名的国家科学中心放射科对转介进行计算机断层扫描(CT)的患者进行3个月的门诊分析。结果和讨论:已经确定的是,在主要情况下,临床医生在为研究签发转诊时,忽略诸如诊断之类的项目,或者用“检查”一词代替它。考虑到这些研究的可变性和医生在适应症和特定研究的必要性方面的认识不足,这些研究的转诊也没有根据和不正确。结论:临床医生对计算机断层扫描转诊的正确性认识不足,因此写出了不正确的转诊。
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引用次数: 0
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BULLETIN OF SURGERY IN KAZAKHSTAN
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