Pub Date : 2025-01-24DOI: 10.1016/j.oraloncology.2025.107185
Zhuomiao Ye , Xin Li , Fei Xie , Jie Sun , Dan Yang , Chao Deng , Mingzhu Yin
NUT carcinoma is a rare and highly aggressive malignancy, predominantly affecting adolescents and young adults. This tumor demonstrates rapid progression, resistance to conventional anti-cancer treatments, and an extremely poor prognosis. Currently, research on NUT carcinoma is limited, and effective treatment options remain scarce. In this study, we performed single-cell RNA sequencing (scRNA-seq) on tumor tissue from a 13-year-old patient with maxillary sinus NUT carcinoma. The analysis revealed significant heterogeneity among epithelial cells within the tumor microenvironment (TME). Immune cell infiltration was notably low, suggesting that the tumor represents a “cold” immune microenvironment. Subclustering of epithelial cells identified distinct subpopulations characterized by high proliferation, metabolic activity, TGF-Beta-driven invasiveness, and MYC-driven growth and protein secretion. These findings provide critical insights into the tumor’s biology, growth mechanisms, and potential therapeutic vulnerabilities. This study highlights the importance of scRNA-seq in understanding the complexity of NUT carcinoma and underscores the need for personalized treatment approaches, including the potential application of BET inhibitors.
{"title":"A single-cell sequencing-based analysis of a 13-year-old with maxillary sinus NUT carcinoma","authors":"Zhuomiao Ye , Xin Li , Fei Xie , Jie Sun , Dan Yang , Chao Deng , Mingzhu Yin","doi":"10.1016/j.oraloncology.2025.107185","DOIUrl":"10.1016/j.oraloncology.2025.107185","url":null,"abstract":"<div><div>NUT carcinoma is a rare and highly aggressive malignancy, predominantly affecting adolescents and young adults. This tumor demonstrates rapid progression, resistance to conventional anti-cancer treatments, and an extremely poor prognosis. Currently, research on NUT carcinoma is limited, and effective treatment options remain scarce. In this study, we performed single-cell RNA sequencing (scRNA-seq) on tumor tissue from a 13-year-old patient with maxillary sinus NUT carcinoma. The analysis revealed significant heterogeneity among epithelial cells within the tumor microenvironment (TME). Immune cell infiltration was notably low, suggesting that the tumor represents a “cold” immune microenvironment. Subclustering of epithelial cells identified distinct subpopulations characterized by high proliferation, metabolic activity, TGF-Beta-driven invasiveness, and MYC-driven growth and protein secretion. These findings provide critical insights into the tumor’s biology, growth mechanisms, and potential therapeutic vulnerabilities. This study highlights the importance of scRNA-seq in understanding the complexity of NUT carcinoma and underscores the need for personalized treatment approaches, including the potential application of BET inhibitors.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"162 ","pages":"Article 107185"},"PeriodicalIF":4.0,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143040695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-24DOI: 10.1016/j.oraloncology.2025.107183
Siying Li , Yingxin Zhang , Huanyan Dai , Zhimin Xu
Calcifying epithelial odontogenic tumor (CEOT) is a rare benign odontogenic epithelial tumor characterized by the presence of amyloid material within the tumor that can undergo calcification. CEOT affects individuals across a broad age range, typically between 20 and 60 years, with an average onset age of 40 years. However, it is extremely rare in children and adolescents. According to the literature, only 31 cases of CEOT in children and adolescents have been reported from 1971 to 2023, accounting for approximately 7 % of all CEOT cases. In the 2022 WHO classification of odontogenic tumors, CEOT is classified as a benign tumor, but it is inherently locally aggressive, capable of invading surrounding normal jawbone tissues, with a recurrence rate of 10–15 %. In this paper, we report a case of a 13-year-old male with a recurrence of CEOT in the mandible 43 months after surgery, covering clinical, imaging, histologic, immunohistochemical, and surgical aspects, and discuss its histopathologic features and treatment options.
{"title":"A rare case of recurrent calcifying epithelial odontogenic tumor in an adolescent patient: Case report and review of literature","authors":"Siying Li , Yingxin Zhang , Huanyan Dai , Zhimin Xu","doi":"10.1016/j.oraloncology.2025.107183","DOIUrl":"10.1016/j.oraloncology.2025.107183","url":null,"abstract":"<div><div>Calcifying epithelial odontogenic tumor (CEOT) is a rare benign odontogenic epithelial tumor characterized by the presence of amyloid material within the tumor that can undergo calcification. CEOT affects individuals across a broad age range, typically between 20 and 60 years, with an average onset age of 40 years. However, it is extremely rare in children and adolescents. According to the literature, only 31 cases of CEOT in children and adolescents have been reported from 1971 to 2023, accounting for approximately 7 % of all CEOT cases. In the 2022 WHO classification of odontogenic tumors, CEOT is classified as a benign tumor, but it is inherently locally aggressive, capable of invading surrounding normal jawbone tissues, with a recurrence rate of 10–15 %. In this paper, we report a case of a 13-year-old male with a recurrence of CEOT in the mandible 43 months after surgery, covering clinical, imaging, histologic, immunohistochemical, and surgical aspects, and discuss its histopathologic features and treatment options.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"162 ","pages":"Article 107183"},"PeriodicalIF":4.0,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143040692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cancer stem cells (CSCs) are considered key drivers of progression in head and neck squamous cell carcinoma (HNSCC). Our single-cell RNA sequencing (scRNA-seq) analysis revealed predominant expression of CD271 in CSCs, however, its role as a CSC marker in HNSCC requires further elucidation. We investigated the stemness characteristics of CD271high HNSCC cells and their interactions with the tumor immune microenvironment.
Methods
scRNA-seq data from hypopharyngeal squamous cell carcinoma (HPSCC) tissues were analyzed to identify expression profile of CSCs. Overall survival was compared between CD271high and CD271low patients based on immunostaining of HPSCC samples. The stemness of CD271high HNSCC cells was evaluated via an in vivo limiting dilution assay. In a C57BL/6 mice model, the percentage of immune cells and macrophage subtypes were analyzed by flow cytometry. The role of CD271 in macrophage polarization was further examined by in vitro coculture of CD271high cells with CD14+ monocytes. Gene expressions were analyzed by qPCR.
Results
CD271 is predominantly expressed in CSCs identified by scRNA-seq analysis. CD271 enhances HNSCC cell proliferation and is negatively correlated with patient prognosis in HPSCC. CD271 knockdown suppressed HNSCC tumor growth and regulated macrophage polarization within the TME. CD271high cells exhibited stemness features and enhanced tumor growth in vivo.
Conclusions
CD271high HNSCC cells exhibit CSC characteristics and regulate macrophage polarization. Targeting CD271 may improve the immunosuppressive TME to inhibit tumor growth. Combining CD271-targeting agents with other therapies presents a promising strategy that may enhance therapeutic efficacy and prognosis in HNSCC.
{"title":"CD271high cancer stem cells regulate macrophage polarization in head and neck squamous cell carcinoma","authors":"Lifan Chen , Ruihua Fang , Zhimou Cai, Bixue Huang, Jinhong Zhang, Yun Li, Yi Chen, Zhenglin Xu, Wenbin Lei, Minjuan Zhang","doi":"10.1016/j.oraloncology.2025.107181","DOIUrl":"10.1016/j.oraloncology.2025.107181","url":null,"abstract":"<div><h3>Purpose</h3><div>Cancer stem cells (CSCs) are considered key drivers of progression in head and neck squamous cell carcinoma (HNSCC). Our single-cell RNA sequencing (scRNA-seq) analysis revealed predominant expression of CD271 in CSCs, however, its role as a CSC marker in HNSCC requires further elucidation. We investigated the stemness characteristics of CD271<sup>high</sup> HNSCC cells and their interactions with the tumor immune microenvironment.</div></div><div><h3>Methods</h3><div>scRNA-seq data from hypopharyngeal squamous cell carcinoma (HPSCC) tissues were analyzed to identify expression profile of CSCs. Overall survival was compared between CD271<sup>high</sup> and CD271<sup>low</sup> patients based on immunostaining of HPSCC samples. The stemness of CD271<sup>high</sup> HNSCC cells was evaluated via an in vivo limiting dilution assay. In a C57BL/6 mice model, the percentage of immune cells and macrophage subtypes were analyzed by flow cytometry. The role of CD271 in macrophage polarization was further examined by in vitro coculture of CD271<sup>high</sup> cells with CD14<sup>+</sup> monocytes. Gene expressions were analyzed by qPCR.</div></div><div><h3>Results</h3><div>CD271 is predominantly expressed in CSCs identified by scRNA-seq analysis. CD271 enhances HNSCC cell proliferation and is negatively correlated with patient prognosis in HPSCC. CD271 knockdown suppressed HNSCC tumor growth and regulated macrophage polarization within the TME. CD271<sup>high</sup> cells exhibited stemness features and enhanced tumor growth in vivo.</div></div><div><h3>Conclusions</h3><div>CD271<sup>high</sup> HNSCC cells exhibit CSC characteristics and regulate macrophage polarization. Targeting CD271 may improve the immunosuppressive TME to inhibit tumor growth. Combining CD271-targeting agents with other therapies presents a promising strategy that may enhance therapeutic efficacy and prognosis in HNSCC.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"162 ","pages":"Article 107181"},"PeriodicalIF":4.0,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143040698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-23DOI: 10.1016/j.oraloncology.2025.107180
Alex Charlton , Zahir Mughal , Florida Sharin , Raguwinder Bindy Sahota , Mohammed Shaji Mansuri , Manish Mair
The purpose of this systematic review and meta-analysis was to identify the prevalence of synchronous contralateral tonsil carcinoma (SCTC) amongst patients with tonsil carcinoma or head and neck squamous cell carcinoma of unknown primary (HNSCCUP). Thirteen retrospective studies, comprising 2623 patients, were analysed, revealing an overall pooled SCTC prevalence of 4%, rising to 10% in HNSCCUP cases. HPV/p16 positivity was associated with SCTC prevalence of 3%, while HPV/p16 negativity was greater at 8%. Clinical or imaging evaluations often missed SCTC preoperatively, emphasising the importance of contralateral tonsillectomy. Morbidity varied among patients undergoing contralateral tonsillectomy.
The prevalence of SCTC is significant in cases of HNSCCUP and tonsil malignancy, emphasising the importance of informed discussions regarding contralateral tonsillectomy. Tailored approaches considering individual patient and tumour characteristics are crucial, with contralateral tonsillectomy generally warranted in HNSCCUP. Further research, including prospective studies with standardised protocols, is needed to improve the understanding and management of SCTC, specifically the clinical significance of occult SCTC.
{"title":"Prevalence of synchronous bilateral/contralateral tonsil carcinoma: A systematic review and meta-analysis","authors":"Alex Charlton , Zahir Mughal , Florida Sharin , Raguwinder Bindy Sahota , Mohammed Shaji Mansuri , Manish Mair","doi":"10.1016/j.oraloncology.2025.107180","DOIUrl":"10.1016/j.oraloncology.2025.107180","url":null,"abstract":"<div><div>The purpose of this systematic review and <em>meta</em>-analysis was to identify the prevalence of synchronous contralateral tonsil carcinoma (SCTC) amongst patients with tonsil carcinoma or head and neck squamous cell carcinoma of unknown primary (HNSCCUP). Thirteen retrospective studies, comprising 2623 patients, were analysed, revealing an overall pooled SCTC prevalence of 4%, rising to 10% in HNSCCUP cases. HPV/p16 positivity was associated with SCTC prevalence of 3%, while HPV/p16 negativity was greater at 8%. Clinical or imaging evaluations often missed SCTC preoperatively, emphasising the importance of contralateral tonsillectomy. Morbidity varied among patients undergoing contralateral tonsillectomy.</div><div>The prevalence of SCTC is significant in cases of HNSCCUP and tonsil malignancy, emphasising the importance of informed discussions regarding contralateral tonsillectomy. Tailored approaches considering individual patient and tumour characteristics are crucial, with contralateral tonsillectomy generally warranted in HNSCCUP. Further research, including prospective studies with standardised protocols, is needed to improve the understanding and management of SCTC, specifically the clinical significance of occult SCTC.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"162 ","pages":"Article 107180"},"PeriodicalIF":4.0,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143040702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-22DOI: 10.1016/j.oraloncology.2025.107197
Sichen Han , Cangwei Liu , Xinliang Duan , Yao Yuan , Jiayu Shen , Zilin Wang
{"title":"Sarcomatoid salivary duct carcinoma of Parotid: A case report and Review of the Literature","authors":"Sichen Han , Cangwei Liu , Xinliang Duan , Yao Yuan , Jiayu Shen , Zilin Wang","doi":"10.1016/j.oraloncology.2025.107197","DOIUrl":"10.1016/j.oraloncology.2025.107197","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"162 ","pages":"Article 107197"},"PeriodicalIF":4.0,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01DOI: 10.1016/j.oraloncology.2024.107133
Xuan Xiao , Yajia Xie , Zhaocheng Shi , Zhifeng Song
{"title":"Margin to depth ratio as a prognostic indicator for oral squamous cell carcinoma needs randomized controlled trials","authors":"Xuan Xiao , Yajia Xie , Zhaocheng Shi , Zhifeng Song","doi":"10.1016/j.oraloncology.2024.107133","DOIUrl":"10.1016/j.oraloncology.2024.107133","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"160 ","pages":"Article 107133"},"PeriodicalIF":4.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Salivary gland cancer is a rare disease composed of more than 20 histological types with different grades of malignancy. The aim of this multicenter, retrospective study was to identify the most important predictors affecting recurrence and survival after surgery.
Material and Methods
A total of 543 patients with salivary gland cancers that underwent curative surgery between 2012 and 2022 in 13 institutions in northern Japan were evaluated in this study. Predictors affecting recurrence and survival were identified by univariate and multivariate Cox regression analyses. Age, sex, primary site, histological type, pathological T status, surgical margin, lymph node metastasis, extranodal extension, and postoperative radiotherapy were the variables evaluated.
Results
Multivariate Cox regression analysis showed that increasing age, submandibular cancer, pathological T status 3 or 4, positive surgical margin, and lymph node metastasis, especially with extranodal extension, were independent risk factors for both recurrence and survival. Sublingual cancer was an independent risk factor for recurrence. Postoperative radiotherapy was associated with a lower risk of recurrence and a good prognosis, and adenoid cystic carcinoma was associated with a good prognosis.
Conclusion
Lymph node metastasis with extranodal extension was the most important prognostic factor affecting both recurrence and survival after surgery, adenoid cystic carcinoma was associated with a good prognosis, and postoperative radiotherapy was associated with a lower risk of recurrence and a good prognosis.
{"title":"Predictors of recurrence and survival after salivary gland cancer surgery: A multicenter, retrospective study in northern Japan","authors":"Akira Ohkoshi , Ryo Ishii , Kenjiro Higashi , Tadahisa Shishido , Satoshi Kano , Takahiro Kusaka , Daisuke Matsushita , Kosuke Murayama , Yuya Miyakura , Satoshi Kubota , Ryosuke Sato , Shino Godo , Hiroki Tomizawa , Satoshi Toyoma , Ai Tagawa , Akina Shirotori , Yukio Katori","doi":"10.1016/j.oraloncology.2024.107131","DOIUrl":"10.1016/j.oraloncology.2024.107131","url":null,"abstract":"<div><h3>Objectives</h3><div>Salivary gland cancer is a rare disease composed of more than 20 histological types with different grades of malignancy. The aim of this multicenter, retrospective study was to identify the most important predictors affecting recurrence and survival after surgery.</div></div><div><h3>Material and Methods</h3><div>A total of 543 patients with salivary gland cancers that underwent curative surgery between 2012 and 2022 in 13 institutions in northern Japan were evaluated in this study. Predictors affecting recurrence and survival were identified by univariate and multivariate Cox regression analyses. Age, sex, primary site, histological type, pathological T status, surgical margin, lymph node metastasis, extranodal extension, and postoperative radiotherapy were the variables evaluated.</div></div><div><h3>Results</h3><div>Multivariate Cox regression analysis showed that increasing age, submandibular cancer, pathological T status 3 or 4, positive surgical margin, and lymph node metastasis, especially with extranodal extension, were independent risk factors for both recurrence and survival. Sublingual cancer was an independent risk factor for recurrence. Postoperative radiotherapy was associated with a lower risk of recurrence and a good prognosis, and adenoid cystic carcinoma was associated with a good prognosis.</div></div><div><h3>Conclusion</h3><div>Lymph node metastasis with extranodal extension was the most important prognostic factor affecting both recurrence and survival after surgery, adenoid cystic carcinoma was associated with a good prognosis, and postoperative radiotherapy was associated with a lower risk of recurrence and a good prognosis.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"160 ","pages":"Article 107131"},"PeriodicalIF":4.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142770590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01DOI: 10.1016/j.oraloncology.2024.107124
Jin Wang , Hong Chen , Shuang Fu , Zhen-Ming Xu , Kai-Lai Sun , Wei-Neng Fu
{"title":"Corrigendum to “The involvement of CHD5 hypermethylation in laryngeal squamous cell carcinoma” [Oral Oncol. 47(7) (2011) 601–608]","authors":"Jin Wang , Hong Chen , Shuang Fu , Zhen-Ming Xu , Kai-Lai Sun , Wei-Neng Fu","doi":"10.1016/j.oraloncology.2024.107124","DOIUrl":"10.1016/j.oraloncology.2024.107124","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"160 ","pages":"Article 107124"},"PeriodicalIF":4.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142770526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01DOI: 10.1016/j.oraloncology.2024.107134
Lucas Alves da Mota Santana, Marina dos Santos Barreto, Gilmagno Amado Santos, Rajiv Gandhi Gopalsamy, Bernardo Ferreira Brasileiro, Cleverson Luciano Trento, Lysandro Pinto Borges
{"title":"Comment on “Time to treatment for head and neck cancer patients decreased during the early phase of the COVID-19 pandemic”","authors":"Lucas Alves da Mota Santana, Marina dos Santos Barreto, Gilmagno Amado Santos, Rajiv Gandhi Gopalsamy, Bernardo Ferreira Brasileiro, Cleverson Luciano Trento, Lysandro Pinto Borges","doi":"10.1016/j.oraloncology.2024.107134","DOIUrl":"10.1016/j.oraloncology.2024.107134","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"160 ","pages":"Article 107134"},"PeriodicalIF":4.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01DOI: 10.1016/j.oraloncology.2024.107130
Sarah Mortaja , Francesca Angela Chiumenti , Deepak M. Kalaskar , Raghav C. Dwivedi
Pedicled, fasciocutaneous and visceral flaps are all widely adopted for reconstruction after ablative surgery for advanced laryngeal, hypopharyngeal and cervical oesophageal cancers. With multiple options available, the choice depends on type and extent of the defect, patient’s general conditions and institution expertise or preference.
Since its first description in 1959, the use of jejunal free flap (JFF) has been refined thanks to the introduction of microvascular anastomoses, progressively allowing to achieve low mortality and morbidity rates. Both swallowing and speech outcomes are also positively reported across studies.
A systematic review of English literature on JFF in H&N cancer reconstruction published after 2000 was carried out on Medline and Embase. Thirty-six studies were included in the analysis with a total of 3191 JFF reconstructions. Primary outcomes were surgical complications and functional outcomes (quality of speech and oral alimentation). A cumulative review was created pooling complication rates reported in single studies, and overall rates were obtained for fistulas (11.39%), strictures (14.17%), total and partial flap failure (4.79 and 6.15% respectively) and perioperative mortality (3.1%). Functional outcomes were variably reported, with different qualitative and quantitative assessment methods showing overall positive results. When reported, we’ve included impact of adjuvant radiotherapy and the ability of JFF to tolerate it has been widely confirmed. Above results have also been compared with same outcomes registered for different flaps.
Overall, studies over the past 20 years demonstrate good clinical and functional outcomes, proving JFF to be a reliable and safe method for reconstructing circumferential pharyngoesophageal defects.
{"title":"Surgical complications and functional outcomes of 3191 jejunal free flaps used for reconstruction of circumferential defects following head and neck cancer resections: A systematic review","authors":"Sarah Mortaja , Francesca Angela Chiumenti , Deepak M. Kalaskar , Raghav C. Dwivedi","doi":"10.1016/j.oraloncology.2024.107130","DOIUrl":"10.1016/j.oraloncology.2024.107130","url":null,"abstract":"<div><div>Pedicled, fasciocutaneous and visceral flaps are all widely adopted for reconstruction after ablative surgery for advanced laryngeal, hypopharyngeal and cervical oesophageal cancers. With multiple options available, the choice depends on type and extent of the defect, patient’s general conditions and institution expertise or preference.</div><div>Since its first description in 1959, the use of jejunal free flap (JFF) has been refined thanks to the introduction of microvascular anastomoses, progressively allowing to achieve low mortality and morbidity rates. Both swallowing and speech outcomes are also positively reported across studies.</div><div>A systematic review of English literature on JFF in H&N cancer reconstruction published after 2000 was carried out on Medline and Embase. Thirty-six studies were included in the analysis with a total of 3191 JFF reconstructions. Primary outcomes were surgical complications and functional outcomes (quality of speech and oral alimentation). A cumulative review was created pooling complication rates reported in single studies, and overall rates were obtained for fistulas (11.39%), strictures (14.17%), total and partial flap failure (4.79 and 6.15% respectively) and perioperative mortality (3.1%). Functional outcomes were variably reported, with different qualitative and quantitative assessment methods showing overall positive results. When reported, we’ve included impact of adjuvant radiotherapy and the ability of JFF to tolerate it has been widely confirmed. Above results have also been compared with same outcomes registered for different flaps.</div><div>Overall, studies over the past 20 years demonstrate good clinical and functional outcomes, proving JFF to be a reliable and safe method for reconstructing circumferential pharyngoesophageal defects.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"160 ","pages":"Article 107130"},"PeriodicalIF":4.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142770822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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