首页 > 最新文献

Paediatrics & child health最新文献

英文 中文
L'évaluation médicale en cas de soupçons de trauma crânien causé par la maltraitance des enfants. 对疑似虐待儿童造成的颅脑损伤进行医疗评估。
IF 1.8 4区 医学 Q2 PEDIATRICS Pub Date : 2025-05-01 eCollection Date: 2025-06-01 DOI: 10.1093/pch/pxae072
Michelle Shouldice, Michelle G K Ward, Kathleen Nolan, Emma Cory

Le trauma crânien causé par la maltraitance des enfants, une conséquence grave de la violence envers les enfants, est associé à une morbidité et une mortalité importantes, particulièrement chez les nourrissons et les jeunes enfants. Les professionnels de la santé ont un rôle important à jouer, y compris pour détecter et traiter ces enfants, signaler les craintes de maltraitance aux services de protection de l'enfance, évaluer les lésions et les troubles médicaux connexes, soutenir les enfants et leur famille et transmettre l'information médicale clairement aux familles, aux autres professionnels de la santé, aux services de protection de l'enfance et au milieu juridique. Les symptômes associés aux traumatismes crâniens recoupent souvent ceux d'autres maladies courantes de l'enfance, et les signes externes de lésions peuvent être discrets ou même inexistants. Par conséquent, le trauma crânien causé par la maltraitance des enfants est souvent négligé et détecté tardivement, ce qui contribue au risque que les sévices se poursuivent. Pour évaluer un traumatisme crânien en cas de soupçons de maltraitance d'enfant, il faut examiner les causes médicales éventuelles des observations cliniques et déterminer la présence de lésions occultes. Le présent point de pratique fournit aux professionnels de la santé des conseils pour qu'en cas de soupçons, ils détectent le trauma crânien causé par la maltraitance d'un nourrisson ou d'un enfant et procèdent à l'évaluation médicale des lésions et des blessures.

虐待儿童造成的颅脑创伤是虐待儿童的严重后果,与高发病率和死亡率有关,特别是在婴儿和幼儿中。卫生专业人员们可以发挥重要作用,包括检测和治疗这些孩子,担心举报虐待儿童保护服务、评估及相关医疗疾病,病变的支持儿童与家人和传送信息明确的家属、其他医疗卫生专业人员、儿童保护服务和法律在中间。与头部创伤相关的症状往往与其他常见的儿童疾病重叠,损伤的外部迹象可能是离散的,甚至不存在。因此,虐待儿童造成的颅脑创伤往往被忽视和发现较晚,这增加了虐待继续下去的风险。在怀疑虐待儿童的情况下评估颅脑损伤时,应检查临床观察的可能医学原因,并确定是否存在隐藏损伤。这一做法为卫生保健专业人员提供指导,以便在怀疑虐待婴儿或儿童造成的颅脑创伤时,他们能够发现并对伤害和伤害进行医疗评估。
{"title":"L'évaluation médicale en cas de soupçons de trauma crânien causé par la maltraitance des enfants.","authors":"Michelle Shouldice, Michelle G K Ward, Kathleen Nolan, Emma Cory","doi":"10.1093/pch/pxae072","DOIUrl":"10.1093/pch/pxae072","url":null,"abstract":"<p><p>Le trauma crânien causé par la maltraitance des enfants, une conséquence grave de la violence envers les enfants, est associé à une morbidité et une mortalité importantes, particulièrement chez les nourrissons et les jeunes enfants. Les professionnels de la santé ont un rôle important à jouer, y compris pour détecter et traiter ces enfants, signaler les craintes de maltraitance aux services de protection de l'enfance, évaluer les lésions et les troubles médicaux connexes, soutenir les enfants et leur famille et transmettre l'information médicale clairement aux familles, aux autres professionnels de la santé, aux services de protection de l'enfance et au milieu juridique. Les symptômes associés aux traumatismes crâniens recoupent souvent ceux d'autres maladies courantes de l'enfance, et les signes externes de lésions peuvent être discrets ou même inexistants. Par conséquent, le trauma crânien causé par la maltraitance des enfants est souvent négligé et détecté tardivement, ce qui contribue au risque que les sévices se poursuivent. Pour évaluer un traumatisme crânien en cas de soupçons de maltraitance d'enfant, il faut examiner les causes médicales éventuelles des observations cliniques et déterminer la présence de lésions occultes. Le présent point de pratique fournit aux professionnels de la santé des conseils pour qu'en cas de soupçons, ils détectent le trauma crânien causé par la maltraitance d'un nourrisson ou d'un enfant et procèdent à l'évaluation médicale des lésions et des blessures.</p>","PeriodicalId":19730,"journal":{"name":"Paediatrics & child health","volume":"30 3","pages":"189-194"},"PeriodicalIF":1.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12208362/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144541791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Managing pain in newborns: A multidimensional approach. 新生儿疼痛管理:一种多维方法。
IF 2 4区 医学 Q2 PEDIATRICS Pub Date : 2025-04-28 eCollection Date: 2025-11-01 DOI: 10.1093/pch/pxaf011
Marsha Campbell-Yeo Nnp-Bc, Timothy Disher, Souvik Mitra

Preventing and managing an infant's pain effectively is an essential component of newborn care. Experiencing untreated pain in early life has been associated with immediate negative effects and long-term adverse outcomes affecting physiological stability, pain processing and neurodevelopment. Inadequate pain management during medical procedures is consistently reported by parents as one of the most stressful aspects of having a baby. Despite known ways to effectively manage infant pain, these interventions remain underutilized in clinical practice. To ensure optimal outcomes, health care facilities should establish organization-wide pain management frameworks, with dedicated resources that include: comprehensive training for care providers, implementing pain prevention and control strategies, and quality improvement measures to minimize the number of painful procedures, assess and reassess pain appropriately, reduce procedural and surgery-related pain, and actively engage parents in shared decision-making and pain care.

有效预防和管理婴儿疼痛是新生儿护理的重要组成部分。在生命早期经历未经治疗的疼痛与影响生理稳定性、疼痛处理和神经发育的即时负面影响和长期不良后果有关。在医疗过程中,不适当的疼痛管理一直被父母报告为生孩子最紧张的方面之一。尽管已知的方法有效地管理婴儿疼痛,这些干预措施在临床实践中仍未充分利用。为确保最佳结果,卫生保健机构应建立全组织范围的疼痛管理框架,并配备专用资源,包括:对护理提供者进行全面培训,实施疼痛预防和控制策略,以及质量改进措施,以最大限度地减少疼痛手术的次数,适当地评估和重新评估疼痛,减少手术和手术相关的疼痛,并积极让父母参与共同决策和疼痛护理。
{"title":"Managing pain in newborns: A multidimensional approach.","authors":"Marsha Campbell-Yeo Nnp-Bc, Timothy Disher, Souvik Mitra","doi":"10.1093/pch/pxaf011","DOIUrl":"https://doi.org/10.1093/pch/pxaf011","url":null,"abstract":"<p><p>Preventing and managing an infant's pain effectively is an essential component of newborn care. Experiencing untreated pain in early life has been associated with immediate negative effects and long-term adverse outcomes affecting physiological stability, pain processing and neurodevelopment. Inadequate pain management during medical procedures is consistently reported by parents as one of the most stressful aspects of having a baby. Despite known ways to effectively manage infant pain, these interventions remain underutilized in clinical practice. To ensure optimal outcomes, health care facilities should establish organization-wide pain management frameworks, with dedicated resources that include: comprehensive training for care providers, implementing pain prevention and control strategies, and quality improvement measures to minimize the number of painful procedures, assess and reassess pain appropriately, reduce procedural and surgery-related pain, and actively engage parents in shared decision-making and pain care.</p>","PeriodicalId":19730,"journal":{"name":"Paediatrics & child health","volume":"30 7","pages":"607-623"},"PeriodicalIF":2.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12663794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145649039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Somatic symptom and related disorders: Guidance on assessment and management for paediatric health care providers. 躯体症状和相关疾病:儿科卫生保健提供者评估和管理指南
IF 2 4区 医学 Q2 PEDIATRICS Pub Date : 2025-04-23 eCollection Date: 2025-07-01 DOI: 10.1093/pch/pxae115
Natasha Ruth Saunders, Anne Kawamura, Olivia MacLeod, Alexandra Nieuwesteeg, Claire De Souza

Somatic symptom and related disorders (SSRDs) pose significant challenges in paediatric health care due to their impacts on child and adolescent well-being, functioning, and family systems. This statement offers comprehensive guidance to health care providers on the assessment and management of SSRDs as well as communication strategies for clinical encounters. Specific SSRD diagnoses are outlined along with common clinical presentations and recommended approaches to medical investigations and patient/family communication early in the diagnostic journey. Evidence-based treatments for SSRDs once a diagnosis has been established are delineated. Psychoeducational approaches that help to shift the onus of care from unnecessary medical testing and procedures, thereby shortening the diagnostic journey and promoting more functional, rehabilitative care therapies, are reviewed. Specific strategies to support patients and their families and validate their perspectives are outlined.

躯体症状和相关疾病(ssrd)由于对儿童和青少年的健康、功能和家庭系统的影响,对儿科卫生保健构成了重大挑战。本声明就ssrd的评估和管理以及临床接触的沟通策略向卫生保健提供者提供了全面的指导。具体的SSRD诊断概述了常见的临床表现和推荐的医学调查方法,以及在诊断过程的早期患者/家属沟通。一旦诊断确定,就对ssrd进行循证治疗。心理教育方法有助于将护理的责任从不必要的医学测试和程序中转移出来,从而缩短诊断过程,促进功能更强的康复治疗。概述了支持患者及其家属并验证其观点的具体策略。
{"title":"Somatic symptom and related disorders: Guidance on assessment and management for paediatric health care providers.","authors":"Natasha Ruth Saunders, Anne Kawamura, Olivia MacLeod, Alexandra Nieuwesteeg, Claire De Souza","doi":"10.1093/pch/pxae115","DOIUrl":"https://doi.org/10.1093/pch/pxae115","url":null,"abstract":"<p><p>Somatic symptom and related disorders (SSRDs) pose significant challenges in paediatric health care due to their impacts on child and adolescent well-being, functioning, and family systems. This statement offers comprehensive guidance to health care providers on the assessment and management of SSRDs as well as communication strategies for clinical encounters. Specific SSRD diagnoses are outlined along with common clinical presentations and recommended approaches to medical investigations and patient/family communication early in the diagnostic journey. Evidence-based treatments for SSRDs once a diagnosis has been established are delineated. Psychoeducational approaches that help to shift the onus of care from unnecessary medical testing and procedures, thereby shortening the diagnostic journey and promoting more functional, rehabilitative care therapies, are reviewed. Specific strategies to support patients and their families and validate their perspectives are outlined.</p>","PeriodicalId":19730,"journal":{"name":"Paediatrics & child health","volume":"30 4","pages":"331-337"},"PeriodicalIF":2.0,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12316537/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Les troubles à symptomatologie somatique et apparentés: directives d'évaluation et de prise en charge pour les professionnels de la santé des enfants. 体细胞和相关体征障碍:儿童保健专业人员的评估和管理指南。
IF 2 4区 医学 Q2 PEDIATRICS Pub Date : 2025-04-23 eCollection Date: 2025-07-01 DOI: 10.1093/pch/pxae114
Natasha Ruth Saunders, Anne Kawamura, Olivia MacLeod, Alexandra Nieuwesteeg, Claire De Souza

Les troubles à symptomatologie somatique et apparentés (TSSA) représentent un défi important en pédiatrie en raison de leurs répercussions sur le bien-être et le fonctionnement de l'enfant et de l'adolescent ainsi que sur les systèmes familiaux. Le présent document de principes contient des directives détaillées pour les professionnels de la santé au sujet de l'évaluation et de la prise en charge de ces troubles et des stratégies de communication lors des rencontres cliniques. Les autrices présentent divers diagnostics, de même que les tableaux cliniques fréquents et les approches recommandées pour procéder aux évaluations médicales des patients et des familles et entretenir des communications avec eux dès le début du parcours diagnostique. Ils décrivent les traitements fondés sur des données probantes à adopter après la confirmation du diagnostic. Ils passent également en revue des approches psychoéducatives qui contribuent à éviter le fardeau des soins découlant des interventions et des examens médicaux inutiles et ainsi à raccourcir le parcours diagnostique et à promouvoir des traitements de réadaptation plus fonctionnels. Ils exposent enfin des stratégies particulières pour soutenir les patients et leur famille et pour valider leurs points de vue.

体细胞和相关症状障碍(SSAD)是儿科的一个主要挑战,因为它们影响儿童和青少年以及家庭系统的福祉和功能。本政策文件为卫生保健专业人员提供了关于评估和管理这些疾病的详细指导,以及在临床会议上的沟通策略。作者介绍了各种诊断、常见的临床情况和建议的方法,以便从诊断过程的一开始就对患者和家属进行医疗评估和沟通。它们描述了诊断确认后应采取的循证治疗。他们还审查心理教育方法,以帮助避免不必要的医疗干预和检查带来的护理负担,从而缩短诊断路径,并促进更功能性的康复治疗。最后,他们提出了具体的策略来支持患者和他们的家人,并验证他们的观点。
{"title":"Les troubles à symptomatologie somatique et apparentés: directives d'évaluation et de prise en charge pour les professionnels de la santé des enfants.","authors":"Natasha Ruth Saunders, Anne Kawamura, Olivia MacLeod, Alexandra Nieuwesteeg, Claire De Souza","doi":"10.1093/pch/pxae114","DOIUrl":"https://doi.org/10.1093/pch/pxae114","url":null,"abstract":"<p><p>Les troubles à symptomatologie somatique et apparentés (TSSA) représentent un défi important en pédiatrie en raison de leurs répercussions sur le bien-être et le fonctionnement de l'enfant et de l'adolescent ainsi que sur les systèmes familiaux. Le présent document de principes contient des directives détaillées pour les professionnels de la santé au sujet de l'évaluation et de la prise en charge de ces troubles et des stratégies de communication lors des rencontres cliniques. Les autrices présentent divers diagnostics, de même que les tableaux cliniques fréquents et les approches recommandées pour procéder aux évaluations médicales des patients et des familles et entretenir des communications avec eux dès le début du parcours diagnostique. Ils décrivent les traitements fondés sur des données probantes à adopter après la confirmation du diagnostic. Ils passent également en revue des approches psychoéducatives qui contribuent à éviter le fardeau des soins découlant des interventions et des examens médicaux inutiles et ainsi à raccourcir le parcours diagnostique et à promouvoir des traitements de réadaptation plus fonctionnels. Ils exposent enfin des stratégies particulières pour soutenir les patients et leur famille et pour valider leurs points de vue.</p>","PeriodicalId":19730,"journal":{"name":"Paediatrics & child health","volume":"30 4","pages":"338-345"},"PeriodicalIF":2.0,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12316530/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Medical assessment of suspected traumatic head injury due to child maltreatment (THI-CM). 疑似儿童虐待所致创伤性头部损伤的医学评估。
IF 2 4区 医学 Q2 PEDIATRICS Pub Date : 2025-04-23 eCollection Date: 2025-06-01 DOI: 10.1093/pch/pxae073
Michelle Shouldice, Michelle G K Ward, Kathleen Nolan, Emma Cory

Traumatic head injury due to child maltreatment (THI-CM) is a serious form of child abuse with significant morbidity and mortality, particularly in infants and young children. Healthcare providers have important roles to play, including identifying and treating these children, reporting concerns of child maltreatment to child welfare authorities, assessing for associated injuries and medical conditions, supporting children and their families, and communicating medical information clearly to families and other medical, child welfare, and legal professionals. Symptoms associated with head trauma often overlap with those of other common childhood illnesses, and external signs of injury may be subtle or absent. As a result, THI-CM is frequently overlooked and its identification is often delayed, leading to a risk of ongoing injury. Assessing for head trauma in cases of possible child maltreatment includes considering medical causes for clinical findings and assessment for occult injuries. This practice point provides health care providers with guidance for identifying and medically assessing suspected THI-CM in infants and children.

儿童虐待造成的创伤性头部损伤(THI-CM)是一种严重的儿童虐待形式,发病率和死亡率很高,特别是在婴儿和幼儿中。医疗保健提供者可以发挥重要作用,包括识别和治疗这些儿童,向儿童福利当局报告儿童虐待问题,评估相关伤害和医疗状况,支持儿童及其家庭,并向家庭和其他医疗、儿童福利和法律专业人员清楚地传达医疗信息。与头部创伤相关的症状通常与其他常见儿童疾病的症状重叠,损伤的外部迹象可能很微妙或不存在。因此,THI-CM经常被忽视,其识别往往被延迟,导致持续损伤的风险。在可能的儿童虐待案件中,对头部创伤的评估包括考虑临床发现的医学原因和对隐性损伤的评估。这个实践点为医疗保健提供者提供指导,以确定和医学上评估婴儿和儿童疑似THI-CM。
{"title":"Medical assessment of suspected traumatic head injury due to child maltreatment (THI-CM).","authors":"Michelle Shouldice, Michelle G K Ward, Kathleen Nolan, Emma Cory","doi":"10.1093/pch/pxae073","DOIUrl":"10.1093/pch/pxae073","url":null,"abstract":"<p><p>Traumatic head injury due to child maltreatment (THI-CM) is a serious form of child abuse with significant morbidity and mortality, particularly in infants and young children. Healthcare providers have important roles to play, including identifying and treating these children, reporting concerns of child maltreatment to child welfare authorities, assessing for associated injuries and medical conditions, supporting children and their families, and communicating medical information clearly to families and other medical, child welfare, and legal professionals. Symptoms associated with head trauma often overlap with those of other common childhood illnesses, and external signs of injury may be subtle or absent. As a result, THI-CM is frequently overlooked and its identification is often delayed, leading to a risk of ongoing injury. Assessing for head trauma in cases of possible child maltreatment includes considering medical causes for clinical findings and assessment for occult injuries. This practice point provides health care providers with guidance for identifying and medically assessing suspected THI-CM in infants and children.</p>","PeriodicalId":19730,"journal":{"name":"Paediatrics & child health","volume":"30 3","pages":"184-196"},"PeriodicalIF":2.0,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12402887/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144993151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Home-based phototherapy for neonatal hyperbilirubinemia: A one-time Canadian Paediatric Surveillance Program Survey. 新生儿高胆红素血症的家庭光疗:一次加拿大儿科监测项目调查。
IF 2 4区 医学 Q2 PEDIATRICS Pub Date : 2025-04-17 eCollection Date: 2025-07-01 DOI: 10.1093/pch/pxae045
Karissa Young, Charlotte Moore Hepburn, Michael Miller, Farah Abdulsatar

Objectives: Home-based phototherapy (HP) has gained traction as an alternative to hospital-based treatment for neonatal hyperbilirubinemia, but the safety of this practice remains unclear. This study aimed to identify adverse events (AEs) associated with HP in Canada.

Methods: A one-time survey, distributed through the Canadian Paediatric Surveillance Program, collected retrospective data from paediatricians. The survey included questions about the use of HP, AEs associated with HP, potential HP AE risk factors, and outcomes. A descriptive statistical analysis was conducted.

Results: The survey response rate was 31% (844/2741), with 497 respondents indicating that they provide care for neonatal hyperbilirubinemia. Among those 497 respondents, 58 (12%) reported working at a centre that provides HP. AEs were reported by 15 (3%) physicians with 21 cases of AEs associated with HP in the preceding 12 months. Most AEs resulted in admissions or readmissions to the hospital for inpatient phototherapy. No serious AEs or long-term consequences were reported. Risk factors were identified in 67% of cases, with infant-related factors identified more frequently than provider, system, or family-related factors. Formal protocols for patient assessment and follow-up were in place at most centres that provide HP.

Conclusion: This survey revealed no serious AEs related to HP, as reported by paediatricians in Canada, in the preceding 12 months. The survey also revealed that while HP is available in Canada, there is limited access and a lack of standardization to its administration. This study provides valuable insights into the safety and practice of HP for neonatal hyperbilirubinemia in Canada.

目的:以家庭为基础的光疗(HP)作为新生儿高胆红素血症的医院治疗的替代方案已经获得了关注,但这种做法的安全性尚不清楚。本研究旨在确定加拿大HP相关的不良事件(ae)。方法:通过加拿大儿科监测项目进行一次性调查,收集儿科医生的回顾性数据。调查的问题包括HP的使用、HP相关的AE、HP AE的潜在危险因素和结果。进行描述性统计分析。结果:调查回复率为31%(844/2741),497名受访者表示他们为新生儿高胆红素血症提供护理。在这497名受访者中,有58名(12%)表示在为惠普提供服务的中心工作。15名(3%)医生报告了ae,其中21例ae在过去12个月内与HP相关。大多数ae导致住院或再入院接受住院光疗。没有严重不良反应或长期后果的报道。在67%的病例中发现了危险因素,与婴儿相关的因素比提供者、系统或家庭相关的因素更频繁地被发现。大多数提供HP的中心都有正式的病人评估和随访方案。结论:这项调查显示,在过去的12个月里,没有加拿大儿科医生报告的与HP相关的严重ae。调查还显示,虽然惠普在加拿大可以买到,但访问有限,其管理缺乏标准化。这项研究为加拿大新生儿高胆红素血症HP治疗的安全性和实践提供了有价值的见解。
{"title":"Home-based phototherapy for neonatal hyperbilirubinemia: A one-time Canadian Paediatric Surveillance Program Survey.","authors":"Karissa Young, Charlotte Moore Hepburn, Michael Miller, Farah Abdulsatar","doi":"10.1093/pch/pxae045","DOIUrl":"10.1093/pch/pxae045","url":null,"abstract":"<p><strong>Objectives: </strong>Home-based phototherapy (HP) has gained traction as an alternative to hospital-based treatment for neonatal hyperbilirubinemia, but the safety of this practice remains unclear. This study aimed to identify adverse events (AEs) associated with HP in Canada.</p><p><strong>Methods: </strong>A one-time survey, distributed through the Canadian Paediatric Surveillance Program, collected retrospective data from paediatricians. The survey included questions about the use of HP, AEs associated with HP, potential HP AE risk factors, and outcomes. A descriptive statistical analysis was conducted.</p><p><strong>Results: </strong>The survey response rate was 31% (844/2741), with 497 respondents indicating that they provide care for neonatal hyperbilirubinemia. Among those 497 respondents, 58 (12%) reported working at a centre that provides HP. AEs were reported by 15 (3%) physicians with 21 cases of AEs associated with HP in the preceding 12 months. Most AEs resulted in admissions or readmissions to the hospital for inpatient phototherapy. No serious AEs or long-term consequences were reported. Risk factors were identified in 67% of cases, with infant-related factors identified more frequently than provider, system, or family-related factors. Formal protocols for patient assessment and follow-up were in place at most centres that provide HP.</p><p><strong>Conclusion: </strong>This survey revealed no serious AEs related to HP, as reported by paediatricians in Canada, in the preceding 12 months. The survey also revealed that while HP is available in Canada, there is limited access and a lack of standardization to its administration. This study provides valuable insights into the safety and practice of HP for neonatal hyperbilirubinemia in Canada.</p>","PeriodicalId":19730,"journal":{"name":"Paediatrics & child health","volume":"30 4","pages":"279-283"},"PeriodicalIF":2.0,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12316525/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effects of recreational cannabis legalization in Alberta on poison control centre calls and paediatric emergency department visits. 艾伯塔省娱乐性大麻合法化对中毒控制中心电话和儿科急诊室就诊的影响。
IF 2 4区 医学 Q2 PEDIATRICS Pub Date : 2025-04-11 eCollection Date: 2025-07-01 DOI: 10.1093/pch/pxae090
Sarah Johnson, Dominic Allain, Scott Lucyk, Michelle Simonelli, Theresa Loch, Mathieu Chin

Objectives: To characterize cannabis-related presentations to the two major paediatric emergency departments (EDs) in Alberta as well as calls to Alberta's Poison and Drug Information Services (PADIS) and detect any changes in relation to legalization.

Methods: This was a retrospective medical record review analyzing all paediatric (ages 0 to 18) ED presentations for cannabis-related concerns. The two sites included were the Stollery Children's Hospital in Edmonton and the Alberta Children's Hospital in Calgary. We searched the PADIS database for all calls in the province for 'Cannabinoids and Analogues' for ages 0 to 19. The rates prior to and after legalization were compared.

Results: While we saw no overall difference in ED visits, pre- and post-legislation we found an increase in unintentional overdoses in children under 12 years of age (7% versus 15%, proportion change 1.13). The severity of presentations did not change during this time period (37% versus 42%, P 0.254). We also found an increase in calls to PADIS in the 2 years after legalization. There was an increase in exposure to edible cannabis formulations during this time period.

Conclusion: This study combines a province-wide medical record review of ED visits with poison control centre information to provide a complete look at cannabis intoxication in paediatric patients over the time of legalization. It adds to the growing body of evidence that legalization of recreational cannabis, especially edible formulations has resulted in increased unintentional overdoses in young children.

目标:描述向艾伯塔省两个主要儿科急诊科(ed)介绍大麻相关情况以及向艾伯塔省毒药和药物信息服务(PADIS)打电话的情况,并发现与大麻合法化有关的任何变化。方法:这是一项回顾性的医疗记录回顾,分析了所有儿童(0至18岁)与大麻相关的ED表现。这两个地点是埃德蒙顿的斯托勒里儿童医院和卡尔加里的阿尔伯塔儿童医院。我们在PADIS数据库中搜索了全省0至19岁的“大麻素和类似物”的所有呼叫。比较了合法化前后的比率。结果:虽然我们没有看到急诊就诊的总体差异,但立法前和立法后,我们发现12岁以下儿童的意外过量用药增加(7%对15%,比例变化1.13)。在此期间,症状的严重程度没有变化(37%对42%,P 0.254)。我们还发现,在合法化后的两年内,对PADIS的呼吁有所增加。在此期间,食用大麻制剂的暴露量有所增加。结论:本研究结合了全省医疗记录审查的访问与中毒控制中心的信息,以提供一个完整的看大麻中毒的儿科患者在合法化的时间。越来越多的证据表明,娱乐性大麻,尤其是可食用配方大麻的合法化,导致幼儿意外过量服用的情况有所增加。
{"title":"The effects of recreational cannabis legalization in Alberta on poison control centre calls and paediatric emergency department visits.","authors":"Sarah Johnson, Dominic Allain, Scott Lucyk, Michelle Simonelli, Theresa Loch, Mathieu Chin","doi":"10.1093/pch/pxae090","DOIUrl":"https://doi.org/10.1093/pch/pxae090","url":null,"abstract":"<p><strong>Objectives: </strong>To characterize cannabis-related presentations to the two major paediatric emergency departments (EDs) in Alberta as well as calls to Alberta's Poison and Drug Information Services (PADIS) and detect any changes in relation to legalization.</p><p><strong>Methods: </strong>This was a retrospective medical record review analyzing all paediatric (ages 0 to 18) ED presentations for cannabis-related concerns. The two sites included were the Stollery Children's Hospital in Edmonton and the Alberta Children's Hospital in Calgary. We searched the PADIS database for all calls in the province for 'Cannabinoids and Analogues' for ages 0 to 19. The rates prior to and after legalization were compared.</p><p><strong>Results: </strong>While we saw no overall difference in ED visits, pre- and post-legislation we found an increase in unintentional overdoses in children under 12 years of age (7% versus 15%, proportion change 1.13). The severity of presentations did not change during this time period (37% versus 42%, P 0.254). We also found an increase in calls to PADIS in the 2 years after legalization. There was an increase in exposure to edible cannabis formulations during this time period.</p><p><strong>Conclusion: </strong>This study combines a province-wide medical record review of ED visits with poison control centre information to provide a complete look at cannabis intoxication in paediatric patients over the time of legalization. It adds to the growing body of evidence that legalization of recreational cannabis, especially edible formulations has resulted in increased unintentional overdoses in young children.</p>","PeriodicalId":19730,"journal":{"name":"Paediatrics & child health","volume":"30 4","pages":"268-272"},"PeriodicalIF":2.0,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12316535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Perceptions of caffeine among high school students in the Greater Toronto and Hamilton Area. 大多伦多和汉密尔顿地区中学生对咖啡因的认知。
IF 2 4区 医学 Q2 PEDIATRICS Pub Date : 2025-04-11 eCollection Date: 2025-07-01 DOI: 10.1093/pch/pxae109
Muhammad Akhter Hamid, Manasvi Sai Vanama, Husnain Ahmed, Sumairaa Ahmed, Atchaya Arulchelvan, Sahir Danyal Farooq, Zainab Khan, Nudrat Farheen, Muhib Shah, Masroor Sharfi

Objectives: This clinical cross-sectional study examines the perceptions of caffeine consumption among high school students in the Greater Toronto and Hamilton Area. The purpose of the study is to gain insight into the motives behind caffeine consumption among this population.

Methods: A total of 2273 high school students participated in the study by anonymously filling out an online questionnaire via Cognito forms. The motives behind caffeine consumption can be influenced by the perceptions students hold about caffeine and its effects.

Results: This study reveals that a high proportion (97.2%) of the surveyed high school students reported daily caffeine consumption. Over 80% of these students were consuming more than 100 mg of caffeine per day, surpassing the daily limit recommended by the American Academy of Pediatrics.

Conclusions: These findings highlight the need for targeted interventions and policies aimed at promoting healthier caffeine consumption habits among high school students. The findings of this study have implications for healthcare professionals, policymakers, and parents in understanding adolescent caffeine consumption patterns and providing effective interventions to promote healthy habits.

目的:本临床横断面研究考察了大多伦多和汉密尔顿地区高中生对咖啡因摄入的认知。这项研究的目的是深入了解这一人群摄入咖啡因的动机。方法:采用Cognito在线问卷,对2273名高中生进行匿名调查。咖啡因摄入背后的动机可能受到学生对咖啡因及其作用的看法的影响。结果:本研究显示,在接受调查的高中生中,有很高比例(97.2%)的人报告每天摄入咖啡因。这些学生中超过80%的人每天摄入超过100毫克的咖啡因,超过了美国儿科学会推荐的每日限量。结论:这些发现强调了有针对性的干预和政策的必要性,旨在促进高中生更健康的咖啡因消费习惯。这项研究的发现对医疗保健专业人员、政策制定者和家长了解青少年咖啡因消费模式和提供有效的干预措施以促进健康习惯具有重要意义。
{"title":"Perceptions of caffeine among high school students in the Greater Toronto and Hamilton Area.","authors":"Muhammad Akhter Hamid, Manasvi Sai Vanama, Husnain Ahmed, Sumairaa Ahmed, Atchaya Arulchelvan, Sahir Danyal Farooq, Zainab Khan, Nudrat Farheen, Muhib Shah, Masroor Sharfi","doi":"10.1093/pch/pxae109","DOIUrl":"https://doi.org/10.1093/pch/pxae109","url":null,"abstract":"<p><strong>Objectives: </strong>This clinical cross-sectional study examines the perceptions of caffeine consumption among high school students in the Greater Toronto and Hamilton Area. The purpose of the study is to gain insight into the motives behind caffeine consumption among this population.</p><p><strong>Methods: </strong>A total of 2273 high school students participated in the study by anonymously filling out an online questionnaire via Cognito forms. The motives behind caffeine consumption can be influenced by the perceptions students hold about caffeine and its effects.</p><p><strong>Results: </strong>This study reveals that a high proportion (97.2%) of the surveyed high school students reported daily caffeine consumption. Over 80% of these students were consuming more than 100 mg of caffeine per day, surpassing the daily limit recommended by the American Academy of Pediatrics.</p><p><strong>Conclusions: </strong>These findings highlight the need for targeted interventions and policies aimed at promoting healthier caffeine consumption habits among high school students. The findings of this study have implications for healthcare professionals, policymakers, and parents in understanding adolescent caffeine consumption patterns and providing effective interventions to promote healthy habits.</p>","PeriodicalId":19730,"journal":{"name":"Paediatrics & child health","volume":"30 4","pages":"284-295"},"PeriodicalIF":2.0,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12316520/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Success of amoxicillin challenges in the emergency department for children with low risk of serious reactions. 阿莫西林挑战的成功在急诊科儿童低风险的严重反应。
IF 2 4区 医学 Q2 PEDIATRICS Pub Date : 2025-04-10 eCollection Date: 2025-07-01 DOI: 10.1093/pch/pxae091
Camille Gervais, Luc Panetta, Philippe Ovetchkine, Hélène Roy, Maria Buithieu, Anne Des Roches, Stéphanie Pellerin, Evelyne D Trottier

Objective: This study aimed to address the overdiagnosis of penicillin allergies in the pediatric population, which leads to less effective antibiotic usage. We investigated the effectiveness of standardized oral amoxicillin challenges in the emergency departments (EDs) of pediatric patients with previous reactions but a low risk for serious reactions.

Methods: Children under 18 years of age who reported allergy to any penicillin presenting to the ED of the Centre Hospitalier Universitaire Sainte-Justine (CHUSJ), Montreal, Quebec, Canada, with a clinical requirement for amoxicillin treatment were included if their risk of anaphylaxis was judged to be low. We evaluated immediate and delayed reactions, patient demographics, the impact on resource utilization, and the number of patients no longer considered to be allergic to penicillins at the 1-month follow-up.

Results: From August 2021 through April 2023, 100 children received an oral amoxicillin challenge in the ED. Among them, 93% safely received amoxicillin without an immediate reaction and were discharged with amoxicillin from the ED. Seven participants had immediate reactions which included skin rashes or vomiting, with one participant experiencing an anaphylactic reaction. Five of the seven subsequently had an amoxicillin challenge by an allergist and only the one with anaphylaxis in the ED reacted. Suspected delayed reactions were observed in 4 of the other 89 (4%) participants who could be contacted within 30 days of the challenge and consisted of skin rashes. Three of the four subsequently had an amoxicillin challenge by an allergist and one reacted. Then, two patients (2%) had confirmed allergies following suspected reactions: one patient with the anaphylactic reaction, and the other with the delayed reaction. Overall, 79/89 (89%) of patients with 30-day follow-up could have their allergy label removed without an allergist consultation.

Conclusions: Standardized oral amoxicillin challenges in low-risk pediatric ED patients allowed for the removal of penicillin allergy labels in 89% of patients reached for follow-up without an allergist consultation. This approach enhanced patient care, allowing 93% of participants to be discharged from the ED with an amoxicillin prescription. Only 2 of 100 children had proven amoxicillin allergy; another 3 had reactions but no assessment by an allergist.

目的:本研究旨在解决儿科人群中青霉素过敏的过度诊断,这导致抗生素的使用效果较差。我们调查了在急诊科(EDs)有既往反应但发生严重反应风险低的儿科患者中,标准化口服阿莫西林挑战的有效性。方法:在加拿大魁北克省蒙特利尔市圣贾斯汀大学医院(CHUSJ)急诊科报告对任何青霉素过敏的18岁以下儿童,如果他们的过敏反应风险被判断为低,则纳入阿莫西林治疗的临床要求。我们评估了即时和延迟反应、患者人口统计、对资源利用的影响,以及在1个月的随访中不再被认为对青霉素过敏的患者数量。结果:从2021年8月到2023年4月,100名儿童在急症室接受了口服阿莫西林治疗。其中93%的儿童安全接受了阿莫西林治疗,没有立即反应,并从急症室出院。7名参与者出现了包括皮疹或呕吐在内的立即反应,1名参与者出现了过敏反应。7人中有5人随后接受了过敏专科医生的阿莫西林挑战,只有ED中有过敏反应的人有反应。在其他89名参与者中,有4名(4%)在30天内接触到可疑的延迟反应,包括皮疹。四人中有三人随后接受了过敏专科医生的阿莫西林治疗,其中一人出现了反应。然后,两名患者(2%)在疑似反应后确诊过敏:一名患者为过敏性反应,另一名患者为延迟性反应。总的来说,在30天的随访中,79/89(89%)的患者可以在没有过敏专科医生咨询的情况下去除过敏标签。结论:在低风险儿科急诊科患者中,标准化的口服阿莫西林挑战允许89%的患者在没有过敏专科医生咨询的情况下进行随访。这种方法提高了病人的护理,允许93%的参与者带着阿莫西林处方从急诊科出院。100名儿童中只有2名被证实对阿莫西林过敏;另有3人有过敏反应,但没有经过过敏专科医生的评估。
{"title":"Success of amoxicillin challenges in the emergency department for children with low risk of serious reactions.","authors":"Camille Gervais, Luc Panetta, Philippe Ovetchkine, Hélène Roy, Maria Buithieu, Anne Des Roches, Stéphanie Pellerin, Evelyne D Trottier","doi":"10.1093/pch/pxae091","DOIUrl":"https://doi.org/10.1093/pch/pxae091","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to address the overdiagnosis of penicillin allergies in the pediatric population, which leads to less effective antibiotic usage. We investigated the effectiveness of standardized oral amoxicillin challenges in the emergency departments (EDs) of pediatric patients with previous reactions but a low risk for serious reactions.</p><p><strong>Methods: </strong>Children under 18 years of age who reported allergy to any penicillin presenting to the ED of the Centre Hospitalier Universitaire Sainte-Justine (CHUSJ), Montreal, Quebec, Canada, with a clinical requirement for amoxicillin treatment were included if their risk of anaphylaxis was judged to be low. We evaluated immediate and delayed reactions, patient demographics, the impact on resource utilization, and the number of patients no longer considered to be allergic to penicillins at the 1-month follow-up.</p><p><strong>Results: </strong>From August 2021 through April 2023, 100 children received an oral amoxicillin challenge in the ED. Among them, 93% safely received amoxicillin without an immediate reaction and were discharged with amoxicillin from the ED. Seven participants had immediate reactions which included skin rashes or vomiting, with one participant experiencing an anaphylactic reaction. Five of the seven subsequently had an amoxicillin challenge by an allergist and only the one with anaphylaxis in the ED reacted. Suspected delayed reactions were observed in 4 of the other 89 (4%) participants who could be contacted within 30 days of the challenge and consisted of skin rashes. Three of the four subsequently had an amoxicillin challenge by an allergist and one reacted. Then, two patients (2%) had confirmed allergies following suspected reactions: one patient with the anaphylactic reaction, and the other with the delayed reaction. Overall, 79/89 (89%) of patients with 30-day follow-up could have their allergy label removed without an allergist consultation.</p><p><strong>Conclusions: </strong>Standardized oral amoxicillin challenges in low-risk pediatric ED patients allowed for the removal of penicillin allergy labels in 89% of patients reached for follow-up without an allergist consultation. This approach enhanced patient care, allowing 93% of participants to be discharged from the ED with an amoxicillin prescription. Only 2 of 100 children had proven amoxicillin allergy; another 3 had reactions but no assessment by an allergist.</p>","PeriodicalId":19730,"journal":{"name":"Paediatrics & child health","volume":"30 4","pages":"273-278"},"PeriodicalIF":2.0,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12316527/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Males with Kawasaki disease develop coronary artery aneurysms more than twice as much as females. 患有川崎病的男性患冠状动脉瘤的几率是女性的两倍多。
IF 2 4区 医学 Q2 PEDIATRICS Pub Date : 2025-04-03 eCollection Date: 2025-07-01 DOI: 10.1093/pch/pxae106
Laurence Watelle, Andrea Dahoud, Samuel Blais, Rosie Scuccimarri, Claudia Renaud, Brian W McCrindle, Dereck Human, Frédéric Dallaire, Nagib Dahdah

Objectives: Kawasaki disease (KD) is the leading cause of acquired childhood coronary aneurysms (CAA). Males are more affected than females, with lower survival from cardiac events and normalization rates. This study aimed to determine the association between biological sex and CAA risk and evaluate the association with baseline biochemical inflammatory markers by biological sex.

Methods: This multicenter retrospective cohort study involved children ≤10 years old diagnosed with KD in five Canadian centres. Adjusted CAA risk differences between sexes were computed using binomial regression. Associations between inflammatory markers and CAA risk were analyzed using logistic regression with interaction terms between sex and inflammatory markers.

Results: From 2004 to 2015, 1382 patients were diagnosed with KD and 812 (59%) were males. Median age, fever total duration, and fever duration at therapy initiation were similar between the sexes. The cumulative incidence of medium to large (Z ≥ 5) CAA was higher in males [70/812 (8.6%)] compared to females [19/570 (3.3%)], with an adjusted risk difference of 4.6 % (95% confidence interval [CI] 2.1 to 7.1). Large (Z > 10) aneurysms were more prevalent in males (adjusted risk difference of 3.3%, 95% CI 1.7 to 5.0). Most inflammatory markers were positively associated with CAA risk, but the association was not statistically different between sexes.

Conclusion: Males with KD are at higher risk of developing CAA compared to females. The majority of patients were presumed to be prepubertal, suggesting that hormonal influences are unlikely to be a significant factor. Future KD research based on biological sex categorization should focus on patient risk stratification and long-term prognostic evaluation.

目的:川崎病(KD)是儿童获得性冠状动脉瘤(CAA)的主要病因。男性比女性更容易受到影响,心脏事件的存活率和正常化率较低。本研究旨在确定生物性别与CAA风险之间的关系,并评估生物性别与基线生化炎症标志物的关系。方法:这项多中心回顾性队列研究纳入了加拿大5个中心诊断为KD的≤10岁儿童。使用二项回归计算性别间调整后的CAA风险差异。使用逻辑回归分析炎症标志物与CAA风险之间的关系,并考虑性别和炎症标志物之间的相互作用。结果:2004 - 2015年确诊KD患者1382例,其中男性812例(59%)。治疗开始时的中位年龄、发烧总持续时间和发烧持续时间在两性之间相似。男性中大型(Z≥5)CAA的累积发病率[70/812(8.6%)]高于女性[19/570(3.3%)],调整后的风险差异为4.6%(95%置信区间[CI] 2.1 ~ 7.1)。大动脉瘤(zbbb10)在男性中更为普遍(调整后的风险差异为3.3%,95% CI为1.7 ~ 5.0)。大多数炎症标志物与CAA风险呈正相关,但性别间无统计学差异。结论:男性KD患者发生CAA的风险高于女性。大多数患者被认为是青春期前,这表明激素的影响不太可能是一个重要因素。未来基于生物学性别分类的KD研究应侧重于患者风险分层和长期预后评估。
{"title":"Males with Kawasaki disease develop coronary artery aneurysms more than twice as much as females.","authors":"Laurence Watelle, Andrea Dahoud, Samuel Blais, Rosie Scuccimarri, Claudia Renaud, Brian W McCrindle, Dereck Human, Frédéric Dallaire, Nagib Dahdah","doi":"10.1093/pch/pxae106","DOIUrl":"10.1093/pch/pxae106","url":null,"abstract":"<p><strong>Objectives: </strong>Kawasaki disease (KD) is the leading cause of acquired childhood coronary aneurysms (CAA). Males are more affected than females, with lower survival from cardiac events and normalization rates. This study aimed to determine the association between biological sex and CAA risk and evaluate the association with baseline biochemical inflammatory markers by biological sex.</p><p><strong>Methods: </strong>This multicenter retrospective cohort study involved children ≤10 years old diagnosed with KD in five Canadian centres. Adjusted CAA risk differences between sexes were computed using binomial regression. Associations between inflammatory markers and CAA risk were analyzed using logistic regression with interaction terms between sex and inflammatory markers.</p><p><strong>Results: </strong>From 2004 to 2015, 1382 patients were diagnosed with KD and 812 (59%) were males. Median age, fever total duration, and fever duration at therapy initiation were similar between the sexes. The cumulative incidence of medium to large (Z ≥ 5) CAA was higher in males [70/812 (8.6%)] compared to females [19/570 (3.3%)], with an adjusted risk difference of 4.6 % (95% confidence interval [CI] 2.1 to 7.1). Large (Z > 10) aneurysms were more prevalent in males (adjusted risk difference of 3.3%, 95% CI 1.7 to 5.0). Most inflammatory markers were positively associated with CAA risk, but the association was not statistically different between sexes.</p><p><strong>Conclusion: </strong>Males with KD are at higher risk of developing CAA compared to females. The majority of patients were presumed to be prepubertal, suggesting that hormonal influences are unlikely to be a significant factor. Future KD research based on biological sex categorization should focus on patient risk stratification and long-term prognostic evaluation.</p>","PeriodicalId":19730,"journal":{"name":"Paediatrics & child health","volume":"30 4","pages":"250-256"},"PeriodicalIF":2.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12316523/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Paediatrics & child health
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1