首页 > 最新文献

The Clinical neuropsychologist最新文献

英文 中文
Cognitive measures in the Canadian Longitudinal Study on Aging 加拿大老龄化纵向研究中的认知测量
Pub Date : 2017-01-02 DOI: 10.1080/13854046.2016.1254279
H. Tuokko, L. Griffith, M. Simard, V. Taler
Abstract Objective: We describe the implementation of cognitive measures within the Canadian Longitudinal Study on Aging (CLSA), a nationwide, epidemiological study of aging, and relate CLSA Tracking cohort data (n over 20,000) to previous studies using these measures.Method: CLSA participants (aged 45–85, n over 50,000) provided demographic, social, physical/clinical, psychological, economic, and health service utilization information relevant to health and aging through telephone interviews (Tracking cohort, n over 20,000) or in-person (i.e. Comprehensive cohort, n over 30,000) in both official languages (i.e. English, French). Cognitive measures included: the Rey Auditory Verbal Learning Test (RAVLT) – Trial 1 and five-minute delayed recall; Animal Fluency (AF), the Mental Alternation Test (MAT) (both cohorts); Controlled Oral Word Association Test, Stroop Test, Prospective Memory Test, and Choice reaction times (Comprehensive Cohort).Results: Performance on the RAVLT Trial 1 and AF were very similar to comparable groups studied previously; CLSA sample sizes were far larger. Within the CLSA Tracking cohort, main effects of age and language were observed for all cognitive measures except RAVLT delayed recall. Interaction effects (language × age) were observed for AF.Conclusion: This preliminary examination of the CLSA Tracking cognitive measures lends support to their use in large studies of aging. The CLSA has the potential to provide the ‘best’ comparison data for adult Canadians generated to date and may also be applicable more broadly. Future studies examining relations among the psychological, biological, health, lifestyle, and social measures within the CLSA will make unique contributions to understanding aging.
摘要目的:我们描述了在加拿大老龄化纵向研究(CLSA)中认知测量的实施情况,这是一项全国性的老龄化流行病学研究,并将CLSA跟踪队列数据(n超过20,000)与先前使用这些测量方法的研究联系起来。方法:里昂证券参与者(年龄45-85岁,超过5万人)通过电话访谈(追踪队列,超过2万人)或面对面访谈(即综合队列,超过3万人),以两种官方语言(即英语、法语)提供与健康和老龄化相关的人口、社会、身体/临床、心理、经济和卫生服务利用信息。认知测试包括:雷伊听觉语言学习测试(RAVLT) -试验一和五分钟延迟回忆;动物流畅性(AF),精神交替测试(MAT)(两个队列);对照口语单词联想测验、Stroop测验、前瞻记忆测验和选择反应时间(综合队列)。结果:RAVLT试验1和AF的表现与先前研究的可比组非常相似;里昂证券的样本量要大得多。在里昂证券跟踪队列中,年龄和语言对所有认知测量的主要影响被观察到,除了RAVLT延迟回忆。观察到af的相互作用效应(语言与年龄)。结论:里昂证券跟踪认知测量的初步检查为其在衰老的大型研究中的应用提供了支持。里昂证券有可能为迄今为止生成的加拿大成年人提供“最佳”比较数据,也可能更广泛地适用。未来在里昂证券内部对心理、生物、健康、生活方式和社会措施之间关系的研究将对理解老龄化做出独特的贡献。
{"title":"Cognitive measures in the Canadian Longitudinal Study on Aging","authors":"H. Tuokko, L. Griffith, M. Simard, V. Taler","doi":"10.1080/13854046.2016.1254279","DOIUrl":"https://doi.org/10.1080/13854046.2016.1254279","url":null,"abstract":"Abstract Objective: We describe the implementation of cognitive measures within the Canadian Longitudinal Study on Aging (CLSA), a nationwide, epidemiological study of aging, and relate CLSA Tracking cohort data (n over 20,000) to previous studies using these measures.Method: CLSA participants (aged 45–85, n over 50,000) provided demographic, social, physical/clinical, psychological, economic, and health service utilization information relevant to health and aging through telephone interviews (Tracking cohort, n over 20,000) or in-person (i.e. Comprehensive cohort, n over 30,000) in both official languages (i.e. English, French). Cognitive measures included: the Rey Auditory Verbal Learning Test (RAVLT) – Trial 1 and five-minute delayed recall; Animal Fluency (AF), the Mental Alternation Test (MAT) (both cohorts); Controlled Oral Word Association Test, Stroop Test, Prospective Memory Test, and Choice reaction times (Comprehensive Cohort).Results: Performance on the RAVLT Trial 1 and AF were very similar to comparable groups studied previously; CLSA sample sizes were far larger. Within the CLSA Tracking cohort, main effects of age and language were observed for all cognitive measures except RAVLT delayed recall. Interaction effects (language × age) were observed for AF.Conclusion: This preliminary examination of the CLSA Tracking cognitive measures lends support to their use in large studies of aging. The CLSA has the potential to provide the ‘best’ comparison data for adult Canadians generated to date and may also be applicable more broadly. Future studies examining relations among the psychological, biological, health, lifestyle, and social measures within the CLSA will make unique contributions to understanding aging.","PeriodicalId":197334,"journal":{"name":"The Clinical neuropsychologist","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129471342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 67
Acting President’s Annual State of the Academy Report 代理总统的年度学院状况报告
Pub Date : 2017-01-02 DOI: 10.1080/13854046.2016.1262992
C. Morrison
ISSN: 1385-4046 (Print) 1744-4144 (Online) Journal homepage: http://www.tandfonline.com/loi/ntcn20 Acting President’s Annual State of the Academy Report Chris Morrison To cite this article: Chris Morrison (2017) Acting President’s Annual State of the Academy Report, The Clinical Neuropsychologist, 31:1, 1-15, DOI: 10.1080/13854046.2016.1262992 To link to this article: http://dx.doi.org/10.1080/13854046.2016.1262992
ISSN: 1385-4046(印刷)1744-4144(在线)期刊主页:http://www.tandfonline.com/loi/ntcn20代理总统年度学院报告克里斯·莫里森引用本文:克里斯·莫里森(2017)代理总统年度学院报告,临床神经心理学家,31:1,1-15,DOI: 10.1080/13854046.2016.1262992链接到本文:http://dx.doi.org/10.1080/13854046.2016.1262992
{"title":"Acting President’s Annual State of the Academy Report","authors":"C. Morrison","doi":"10.1080/13854046.2016.1262992","DOIUrl":"https://doi.org/10.1080/13854046.2016.1262992","url":null,"abstract":"ISSN: 1385-4046 (Print) 1744-4144 (Online) Journal homepage: http://www.tandfonline.com/loi/ntcn20 Acting President’s Annual State of the Academy Report Chris Morrison To cite this article: Chris Morrison (2017) Acting President’s Annual State of the Academy Report, The Clinical Neuropsychologist, 31:1, 1-15, DOI: 10.1080/13854046.2016.1262992 To link to this article: http://dx.doi.org/10.1080/13854046.2016.1262992","PeriodicalId":197334,"journal":{"name":"The Clinical neuropsychologist","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127575787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Cognitive screening in Multiple Sclerosis: the Five-Point Test as a substitute for the PASAT in measuring executive function 多发性硬化症的认知筛查:五点测试替代PASAT测量执行功能
Pub Date : 2017-01-02 DOI: 10.1080/13854046.2016.1241894
Sascha Hansen, Jana Muenssinger, Simona Kronhofmann, S. Lautenbacher, P. Oschmann, Philipp M. Keune
Abstract Objective: The Paced Auditory Serial Addition Test (PASAT) is frequently employed to measure executive functions in patients with Multiple Sclerosis (MS). In the past, the PASAT has often been criticized because of its stressful and demanding requirements. Continuous utilization might also reduce its validity. The Five-Point Test (FPT) by Regard, Strauss, and Knapp ((1982) Children’s production on verbal and non-verbal fluency tasks. Perceptual and Motor Skills, 55, 839–844.) is a short test of figural fluency which might serve as a substitute.Method: 116 patients diagnosed with MS were tested with a short version of the Brief Repeatable Battery (BRB) by Rao and the Cognitive Function Study Group of the National Multiple Sclerosis Society including the PASAT, as well as the FPT. A factor analysis was computed and the frequency of cognitive impairment was calculated for both the original short version of the BRB and the alternative version (involving the FPT).Results: In the factor analysis, PASAT and FPT loaded highest on the same factor (two factors were extracted). The estimation of the frequency of cognitive impairment showed that replacing the PASAT with the FPT did not considerably alter the proportion of patients identified as cognitively impaired.Conclusions: The FPT proved to be a viable alternative to the PASAT in this study. It may be recommended as a possible replacement in neuropsychological screening of MS-patients with the advantage of avoiding the indicated limitations of the PASAT.
摘要目的:节奏性听觉序列加法测验(PASAT)常用于测量多发性硬化症(MS)患者的执行功能。在过去,PASAT经常受到批评,因为它的压力和苛刻的要求。持续使用也可能降低其有效性。Regard、Strauss和Knapp(1982)的五点测验(FPT):儿童在语言和非语言流畅性任务上的生产。知觉和运动技能,55,839 - 844)是一个简短的图形流畅性测试,可以作为替代。方法:由Rao和美国国家多发性硬化症学会认知功能研究组(包括PASAT)以及FPT,对116例诊断为MS的患者进行简短可重复电池(BRB)测试。计算了因子分析,并计算了原始短版本的BRB和替代版本(包括FPT)的认知障碍频率。结果:在因子分析中,PASAT和FPT在同一因子上的负荷最高(提取两个因子)。对认知障碍频率的估计表明,用FPT代替PASAT并没有显著改变认知障碍患者的比例。结论:在本研究中,FPT被证明是PASAT的可行替代方案。它可能被推荐作为ms患者神经心理筛查的可能替代方法,其优点是避免了PASAT的指示局限性。
{"title":"Cognitive screening in Multiple Sclerosis: the Five-Point Test as a substitute for the PASAT in measuring executive function","authors":"Sascha Hansen, Jana Muenssinger, Simona Kronhofmann, S. Lautenbacher, P. Oschmann, Philipp M. Keune","doi":"10.1080/13854046.2016.1241894","DOIUrl":"https://doi.org/10.1080/13854046.2016.1241894","url":null,"abstract":"Abstract Objective: The Paced Auditory Serial Addition Test (PASAT) is frequently employed to measure executive functions in patients with Multiple Sclerosis (MS). In the past, the PASAT has often been criticized because of its stressful and demanding requirements. Continuous utilization might also reduce its validity. The Five-Point Test (FPT) by Regard, Strauss, and Knapp ((1982) Children’s production on verbal and non-verbal fluency tasks. Perceptual and Motor Skills, 55, 839–844.) is a short test of figural fluency which might serve as a substitute.Method: 116 patients diagnosed with MS were tested with a short version of the Brief Repeatable Battery (BRB) by Rao and the Cognitive Function Study Group of the National Multiple Sclerosis Society including the PASAT, as well as the FPT. A factor analysis was computed and the frequency of cognitive impairment was calculated for both the original short version of the BRB and the alternative version (involving the FPT).Results: In the factor analysis, PASAT and FPT loaded highest on the same factor (two factors were extracted). The estimation of the frequency of cognitive impairment showed that replacing the PASAT with the FPT did not considerably alter the proportion of patients identified as cognitively impaired.Conclusions: The FPT proved to be a viable alternative to the PASAT in this study. It may be recommended as a possible replacement in neuropsychological screening of MS-patients with the advantage of avoiding the indicated limitations of the PASAT.","PeriodicalId":197334,"journal":{"name":"The Clinical neuropsychologist","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115042310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 15
Performance validity in undergraduate research participants: a comparison of failure rates across tests and cutoffs 本科研究参与者的绩效效度:跨测试和截止的不合格率的比较
Pub Date : 2017-01-02 DOI: 10.1080/13854046.2016.1217046
K. An, Kristen A. Kaploun, L. Erdodi, Christopher A. Abeare
Abstract Objective: This study compared failure rates on performance validity tests (PVTs) across liberal and conservative cutoffs in a sample of undergraduate students participating in academic research.Method: Participants (n = 120) were administered four free-standing PVTs (Test of Memory Malingering, Word Memory Test, Rey 15-Item Test, Hiscock Forced-Choice Procedure) and three embedded PVTs (Digit Span, letter and category fluency). Participants also reported their perceived level of effort during testing.Results: At liberal cutoffs, 36.7% of the sample failed ≥1 PVTs, 6.7% failed ≥2, and .8% failed 3. At conservative cutoffs, 18.3% of the sample failed ≥1 PVTs, 2.5% failed ≥2, and .8% failed 3. Participants were 3 to 5 times more likely to fail embedded (15.8–30.8%) compared to free-standing PVTs (3.3–10.0%). There was no significant difference in failure rates between native and non-native English speaking participants at either liberal or conservative cutoffs. Additionally, there was no relation between self-reported effort and PVT failure rates.Conclusions: Although PVT failure rates varied as a function of PVTs and cutoffs, between a third and a fifth of the sample failed ≥1 PVTs, consistent with high initial estimates of invalid performance in this population. Embedded PVTs had notably higher failure rates than free-standing PVTs. Assuming optimal effort in research using students as participants without a formal assessment of performance validity introduces a potentially significant confound in the study design.
摘要目的:本研究比较了参与学术研究的本科生在自由主义和保守主义截断点上的绩效效度测试不及格率。方法:对120名被试进行4项独立ptt测试(记忆伪装测试、单词记忆测试、Rey 15题测试、Hiscock强迫选择程序)和3项嵌入式ptt测试(数字广度、字母和类别流畅性)。参与者还报告了他们在测试过程中感知到的努力程度。结果:在自由截止点,36.7%的样本≥1 pvt失败,6.7%≥2 pvt失败,0.8%失败3 pvt。在保守截止点,18.3%的样本≥1 pvt失败,2.5%≥2 pvt失败,0.8%失败3 pvt。参与者失败的可能性是独立pvt(3.3-10.0%)的3 - 5倍(15.8-30.8%)。在自由或保守的临界值上,母语为英语和非母语为英语的参与者的失败率没有显著差异。此外,自我报告的努力和PVT失败率之间没有关系。结论:尽管PVT失败率随PVT和截止时间的变化而变化,但三分之一到五分之一的样本失败≥1个PVT,这与该人群中无效表现的高初始估计一致。嵌入式pvt的故障率明显高于独立式pvt。假设在研究中使用学生作为参与者而没有正式的绩效效度评估的最佳努力会在研究设计中引入潜在的重大混淆。
{"title":"Performance validity in undergraduate research participants: a comparison of failure rates across tests and cutoffs","authors":"K. An, Kristen A. Kaploun, L. Erdodi, Christopher A. Abeare","doi":"10.1080/13854046.2016.1217046","DOIUrl":"https://doi.org/10.1080/13854046.2016.1217046","url":null,"abstract":"Abstract Objective: This study compared failure rates on performance validity tests (PVTs) across liberal and conservative cutoffs in a sample of undergraduate students participating in academic research.Method: Participants (n = 120) were administered four free-standing PVTs (Test of Memory Malingering, Word Memory Test, Rey 15-Item Test, Hiscock Forced-Choice Procedure) and three embedded PVTs (Digit Span, letter and category fluency). Participants also reported their perceived level of effort during testing.Results: At liberal cutoffs, 36.7% of the sample failed ≥1 PVTs, 6.7% failed ≥2, and .8% failed 3. At conservative cutoffs, 18.3% of the sample failed ≥1 PVTs, 2.5% failed ≥2, and .8% failed 3. Participants were 3 to 5 times more likely to fail embedded (15.8–30.8%) compared to free-standing PVTs (3.3–10.0%). There was no significant difference in failure rates between native and non-native English speaking participants at either liberal or conservative cutoffs. Additionally, there was no relation between self-reported effort and PVT failure rates.Conclusions: Although PVT failure rates varied as a function of PVTs and cutoffs, between a third and a fifth of the sample failed ≥1 PVTs, consistent with high initial estimates of invalid performance in this population. Embedded PVTs had notably higher failure rates than free-standing PVTs. Assuming optimal effort in research using students as participants without a formal assessment of performance validity introduces a potentially significant confound in the study design.","PeriodicalId":197334,"journal":{"name":"The Clinical neuropsychologist","volume":"63 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124658140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 86
Spontaneous recovery of memory functions in an untreated case of anti NMDAR encephalitis – a reason to maintain hope 未经治疗的抗NMDAR脑炎患者记忆功能的自发恢复——一个保持希望的理由
Pub Date : 2017-01-02 DOI: 10.1080/13854046.2016.1245358
Katy McIvor, P. Moore
Abstract Objective: Anti N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is an autoimmune disorder that was only fully discovered recently and neuropsychological outcome data remains sparse. We present the case of BA, a 19-year-old male, which illustrates the cognitive outcome in an untreated case over a time period of over 2½ years.Method: We conducted three cognitive assessments, including tests of memory and executive functioning, over this time period and considered the evidence for reliable change in memory function using the Wechsler Advanced Clinical Solutions (ACS) serial assessment package.Results: Our findings revealed mild memory problems 6 months post-discharge with, at best, static and potentially declining memory functioning at follow-up assessment 12 months post-discharge. However, the results of testing at 30 months post-discharge revealed significant improvements in immediate and delayed memory index performances.Conclusions: Our report of a case of anti-NMDAR encephalitis provides evidence for spontaneous improvements in memory functioning occurring more than 2 years after initial assessment and also demonstrates both the utility and potential limitations of the ACS serial assessment software when used in a relatively typical clinical assessment situation.
目的:抗n -甲基- d -天冬氨酸受体(Anti - nmdar)脑炎是一种自身免疫性疾病,最近才被完全发现,神经心理学结果数据仍然很少。我们提出了一个19岁的男性BA的病例,它说明了一个未经治疗的病例在超过2年半的时间里的认知结果。方法:我们在这段时间内进行了三次认知评估,包括记忆和执行功能测试,并使用韦氏高级临床解决方案(ACS)系列评估包考虑记忆功能可靠变化的证据。结果:我们的研究结果显示,出院后6个月出现轻微的记忆问题,出院后12个月的随访评估中,记忆功能最多保持不变,甚至可能下降。然而,出院后30个月的测试结果显示,即时和延迟记忆指数的表现有显著改善。结论:我们报告的一个抗nmdar脑炎病例提供了在初始评估后2年多记忆功能自发改善的证据,也证明了ACS系列评估软件在相对典型的临床评估情况下的实用性和潜在局限性。
{"title":"Spontaneous recovery of memory functions in an untreated case of anti NMDAR encephalitis – a reason to maintain hope","authors":"Katy McIvor, P. Moore","doi":"10.1080/13854046.2016.1245358","DOIUrl":"https://doi.org/10.1080/13854046.2016.1245358","url":null,"abstract":"Abstract Objective: Anti N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is an autoimmune disorder that was only fully discovered recently and neuropsychological outcome data remains sparse. We present the case of BA, a 19-year-old male, which illustrates the cognitive outcome in an untreated case over a time period of over 2½ years.Method: We conducted three cognitive assessments, including tests of memory and executive functioning, over this time period and considered the evidence for reliable change in memory function using the Wechsler Advanced Clinical Solutions (ACS) serial assessment package.Results: Our findings revealed mild memory problems 6 months post-discharge with, at best, static and potentially declining memory functioning at follow-up assessment 12 months post-discharge. However, the results of testing at 30 months post-discharge revealed significant improvements in immediate and delayed memory index performances.Conclusions: Our report of a case of anti-NMDAR encephalitis provides evidence for spontaneous improvements in memory functioning occurring more than 2 years after initial assessment and also demonstrates both the utility and potential limitations of the ACS serial assessment software when used in a relatively typical clinical assessment situation.","PeriodicalId":197334,"journal":{"name":"The Clinical neuropsychologist","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125660897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Practice effects and longitudinal cognitive change in clinically normal older adults differ by Alzheimer imaging biomarker status 临床正常老年人的练习效果和纵向认知变化因阿尔茨海默病成像生物标志物状态而异
Pub Date : 2017-01-02 DOI: 10.1080/13854046.2016.1241303
M. Machulda, Clinton E. Hagen, H. Wiste, M. Mielke, D. Knopman, R. Roberts, P. Vemuri, V. Lowe, C. Jack, R. Petersen
Abstract Objective: The objective of this study was to examine practice effects and longitudinal cognitive change in 190 clinically normal elderly classified according to a two-feature biomarker model for Alzheimer’s disease.Methods: All participants completed neuropsychological testing, MRI, FDG-PET, and PiB-PET at their baseline evaluation. We divided participants into four groups based on neuroimaging measures of amyloid (A+ or A−) and neurodegeneration (N+ or N−) and reexamined cognition at 15- and 30-month intervals.Results: The A−N− group showed significant improvements in the memory and global scores. The A+N− group also showed significant improvements in the memory and global scores as well as attention. The A−N+ group showed a significant decline in attention at 30 months. The A+N+ group showed significant improvements in memory and the global score at 15 months followed by a significant decline in the global score at 30 months.Conclusion: Amyloidosis in the absence of neurodegeneration did not have an adverse impact on practice effects or the 30-month cognitive trajectories. In contrast, participants with neurodegeneration (either A−N+ or A+N+) had worse performance at the 30-month follow-up. Our results show that neurodegeneration has a more deleterious effect on cognition than amyloidosis in clinically normal individuals.
摘要目的:本研究的目的是研究190名临床正常老年人阿尔茨海默病双特征生物标志物模型的实践效果和纵向认知变化。方法:所有参与者在基线评估时完成神经心理测试、MRI、FDG-PET和PiB-PET。我们根据淀粉样蛋白(A+或A -)和神经退行性变(N+或N -)的神经影像学指标将参与者分为四组,并每隔15个月和30个月重新检查认知能力。结果:A - N -组在记忆和整体评分方面有显著改善。A+N -组在记忆力、整体得分和注意力方面也有显著改善。A−N+组在30个月时的注意力显著下降。A+N+组在15个月时表现出记忆力和整体得分的显著改善,随后在30个月时整体得分显著下降。结论:无神经退行性变的淀粉样变性对练习效果或30个月的认知轨迹没有不利影响。相比之下,神经退行性变(A−N+或A+N+)的参与者在30个月的随访中表现更差。我们的研究结果表明,在临床正常个体中,神经变性对认知的有害影响比淀粉样变更大。
{"title":"Practice effects and longitudinal cognitive change in clinically normal older adults differ by Alzheimer imaging biomarker status","authors":"M. Machulda, Clinton E. Hagen, H. Wiste, M. Mielke, D. Knopman, R. Roberts, P. Vemuri, V. Lowe, C. Jack, R. Petersen","doi":"10.1080/13854046.2016.1241303","DOIUrl":"https://doi.org/10.1080/13854046.2016.1241303","url":null,"abstract":"Abstract Objective: The objective of this study was to examine practice effects and longitudinal cognitive change in 190 clinically normal elderly classified according to a two-feature biomarker model for Alzheimer’s disease.Methods: All participants completed neuropsychological testing, MRI, FDG-PET, and PiB-PET at their baseline evaluation. We divided participants into four groups based on neuroimaging measures of amyloid (A+ or A−) and neurodegeneration (N+ or N−) and reexamined cognition at 15- and 30-month intervals.Results: The A−N− group showed significant improvements in the memory and global scores. The A+N− group also showed significant improvements in the memory and global scores as well as attention. The A−N+ group showed a significant decline in attention at 30 months. The A+N+ group showed significant improvements in memory and the global score at 15 months followed by a significant decline in the global score at 30 months.Conclusion: Amyloidosis in the absence of neurodegeneration did not have an adverse impact on practice effects or the 30-month cognitive trajectories. In contrast, participants with neurodegeneration (either A−N+ or A+N+) had worse performance at the 30-month follow-up. Our results show that neurodegeneration has a more deleterious effect on cognition than amyloidosis in clinically normal individuals.","PeriodicalId":197334,"journal":{"name":"The Clinical neuropsychologist","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125302044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 45
Multicomponent analysis of a digital Trail Making Test 数字造径试验的多分量分析
Pub Date : 2017-01-02 DOI: 10.1080/13854046.2016.1238510
R. Fellows, Jessamyn Dahmen, D. Cook, M. Schmitter-Edgecombe
Abstract Objective: The purpose of the current study was to use a newly developed digital tablet-based variant of the TMT to isolate component cognitive processes underlying TMT performance.Method: Similar to the paper-based trail making test, this digital variant consists of two conditions, Part A and Part B. However, this digital version automatically collects additional data to create component subtest scores to isolate cognitive abilities. Specifically, in addition to the total time to completion and number of errors, the digital Trail Making Test (dTMT) records several unique components including the number of pauses, pause duration, lifts, lift duration, time inside each circle, and time between circles. Participants were community-dwelling older adults who completed a neuropsychological evaluation including measures of processing speed, inhibitory control, visual working memory/sequencing, and set-switching. The abilities underlying TMT performance were assessed through regression analyses of component scores from the dTMT with traditional neuropsychological measures.Results: Results revealed significant correlations between paper and digital variants of Part A (rs = .541, p < .001) and paper and digital versions of Part B (rs = .799, p < .001). Regression analyses with traditional neuropsychological measures revealed that Part A components were best predicted by speeded processing, while inhibitory control and visual/spatial sequencing were predictors of specific components of Part B. Exploratory analyses revealed that specific dTMT-B components were associated with a performance-based medication management task.Conclusions: Taken together, these results elucidate specific cognitive abilities underlying TMT performance, as well as the utility of isolating digital components.
摘要目的:本研究的目的是使用新开发的基于数字平板的TMT变体来分离TMT表现背后的组件认知过程。方法:与纸质试道测试类似,该数字版本由A部分和b部分两个条件组成,但该数字版本自动收集额外数据来创建组件子测试分数,以隔离认知能力。具体来说,除了总完成时间和错误次数外,数字轨迹制作测试(dTMT)还记录了几个独特的组件,包括暂停次数、暂停持续时间、提升、提升持续时间、每个圈内的时间以及圈间的时间。参与者是居住在社区的老年人,他们完成了神经心理学评估,包括处理速度、抑制控制、视觉工作记忆/排序和集合转换。通过传统的神经心理学测量方法对dTMT的成分得分进行回归分析,评估了TMT表现的能力。结果:结果显示纸质版和电子版A部分(rs = .541, p < .001)和纸质版和电子版B部分(rs = .799, p < .001)之间存在显著相关性。传统神经心理学测量的回归分析显示,快速加工最能预测A部分成分,而抑制控制和视觉/空间测序是b部分特定成分的预测因子。探索性分析显示,特定dTMT-B成分与基于绩效的药物管理任务相关。综上所述,这些结果阐明了TMT表现背后的特定认知能力,以及隔离数字组件的效用。
{"title":"Multicomponent analysis of a digital Trail Making Test","authors":"R. Fellows, Jessamyn Dahmen, D. Cook, M. Schmitter-Edgecombe","doi":"10.1080/13854046.2016.1238510","DOIUrl":"https://doi.org/10.1080/13854046.2016.1238510","url":null,"abstract":"Abstract Objective: The purpose of the current study was to use a newly developed digital tablet-based variant of the TMT to isolate component cognitive processes underlying TMT performance.Method: Similar to the paper-based trail making test, this digital variant consists of two conditions, Part A and Part B. However, this digital version automatically collects additional data to create component subtest scores to isolate cognitive abilities. Specifically, in addition to the total time to completion and number of errors, the digital Trail Making Test (dTMT) records several unique components including the number of pauses, pause duration, lifts, lift duration, time inside each circle, and time between circles. Participants were community-dwelling older adults who completed a neuropsychological evaluation including measures of processing speed, inhibitory control, visual working memory/sequencing, and set-switching. The abilities underlying TMT performance were assessed through regression analyses of component scores from the dTMT with traditional neuropsychological measures.Results: Results revealed significant correlations between paper and digital variants of Part A (rs = .541, p < .001) and paper and digital versions of Part B (rs = .799, p < .001). Regression analyses with traditional neuropsychological measures revealed that Part A components were best predicted by speeded processing, while inhibitory control and visual/spatial sequencing were predictors of specific components of Part B. Exploratory analyses revealed that specific dTMT-B components were associated with a performance-based medication management task.Conclusions: Taken together, these results elucidate specific cognitive abilities underlying TMT performance, as well as the utility of isolating digital components.","PeriodicalId":197334,"journal":{"name":"The Clinical neuropsychologist","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124365482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 78
Embedded performance validity tests within the Hopkins Verbal Learning Test – Revised and the Brief Visuospatial Memory Test – Revised 霍普金斯语言学习测试-修订版和简短视觉空间记忆测试-修订版中的嵌入性能效度测试
Pub Date : 2017-01-02 DOI: 10.1080/13854046.2016.1245787
R. John Sawyer, S. Marc Testa, M. Dux
Abstract Objective: Various research studies and neuropsychology practice organizations have reiterated the importance of developing embedded performance validity tests (PVTs) to detect potentially invalid neurocognitive test data. This study investigated whether measures within the Hopkins Verbal Learning Test – Revised (HVLT-R) and the Brief Visuospatial Memory Test – Revised (BVMT-R) could accurately classify individuals who fail two or more PVTs during routine clinical assessment.Method: The present sample of 109 United States military veterans (Mean age = 52.4, SD = 13.3), all consisted of clinically referred patients and received a battery of neuropsychological tests. Based on performance validity findings, veterans were assigned to valid (n = 86) or invalid (n = 23) groups. Of the 109 patients in the overall sample, 77 were administered the HLVT-R and 75 were administered the BVMT-R, which were examined for classification accuracy.Results: The HVLT-R Recognition Discrimination Index and the BVMT-R Retention Percentage showed good to adequate discrimination with an area under the curve of .78 and .70, respectively. The HVLT-R Recognition Discrimination Index showed sensitivity of .53 with specificity of .93. The BVMT-R Retention Percentage demonstrated sensitivity of .31 with specificity of .92.Conclusions: When used in conjunction with other PVTs, these new embedded PVTs may be effective in the detection of invalid test data, although they are not intended for use in patients with dementia.
摘要目的:各种研究和神经心理学实践组织都重申了开发嵌入式性能效度测试(pvt)来检测潜在无效的神经认知测试数据的重要性。本研究调查了霍普金斯语言学习测试-修订版(HVLT-R)和简短视觉空间记忆测试-修订版(BVMT-R)中的测量方法是否可以准确地对在常规临床评估中两次或两次以上pvt失败的个体进行分类。方法:109例美国退伍军人(平均年龄52.4岁,SD = 13.3)均为临床转诊患者,接受了一系列神经心理测试。根据效能效度结果,将退伍军人分为有效组(n = 86)和无效组(n = 23)。在109例患者中,77例接受HLVT-R治疗,75例接受BVMT-R治疗,检查其分类准确性。结果:hvmt - r识别鉴别指数和BVMT-R保留百分率为良好至充分鉴别,曲线下面积分别为0.78和0.70。HVLT-R识别鉴别指数敏感性为0.53,特异性为0.93。BVMT-R保留率敏感性为0.31,特异性为0.92。结论:当与其他pvt联合使用时,这些新的嵌入式pvt可能有效地检测无效的测试数据,尽管它们不打算用于痴呆症患者。
{"title":"Embedded performance validity tests within the Hopkins Verbal Learning Test – Revised and the Brief Visuospatial Memory Test – Revised","authors":"R. John Sawyer, S. Marc Testa, M. Dux","doi":"10.1080/13854046.2016.1245787","DOIUrl":"https://doi.org/10.1080/13854046.2016.1245787","url":null,"abstract":"Abstract Objective: Various research studies and neuropsychology practice organizations have reiterated the importance of developing embedded performance validity tests (PVTs) to detect potentially invalid neurocognitive test data. This study investigated whether measures within the Hopkins Verbal Learning Test – Revised (HVLT-R) and the Brief Visuospatial Memory Test – Revised (BVMT-R) could accurately classify individuals who fail two or more PVTs during routine clinical assessment.Method: The present sample of 109 United States military veterans (Mean age = 52.4, SD = 13.3), all consisted of clinically referred patients and received a battery of neuropsychological tests. Based on performance validity findings, veterans were assigned to valid (n = 86) or invalid (n = 23) groups. Of the 109 patients in the overall sample, 77 were administered the HLVT-R and 75 were administered the BVMT-R, which were examined for classification accuracy.Results: The HVLT-R Recognition Discrimination Index and the BVMT-R Retention Percentage showed good to adequate discrimination with an area under the curve of .78 and .70, respectively. The HVLT-R Recognition Discrimination Index showed sensitivity of .53 with specificity of .93. The BVMT-R Retention Percentage demonstrated sensitivity of .31 with specificity of .92.Conclusions: When used in conjunction with other PVTs, these new embedded PVTs may be effective in the detection of invalid test data, although they are not intended for use in patients with dementia.","PeriodicalId":197334,"journal":{"name":"The Clinical neuropsychologist","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130256993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 40
Ascertaining educational outcomes after assessment in children with learning disorders 确定学习障碍儿童评估后的教育成果
Pub Date : 2017-01-02 DOI: 10.1080/13854046.2016.1244289
D. Waber, Ellen C. Boiselle, J. Girard, Joseph L. Amaral, P. Forbes
Abstract Objective: To survey educational outcomes after an interdisciplinary, neuropsychologically based team assessment for learning disorders.Method: Parents of 137 children who underwent a comprehensive interdisciplinary neuropsychologically based assessment for learning problems completed an online survey one to four years later. Questions pertained broadly to school outcomes: positive or negative school responses, changes in special education services, and parental perceptions about the helpfulness of those services. These outcomes were examined in relation to demographic characteristics and parent satisfaction with the evaluation. We also obtained recent performance on state-based academic testing for descriptive purposes.Results: Parents reported that schools generally responded positively (78%), and 70% reported that their children had access to more or different special education services after the evaluation. Parents nearly uniformly (98%) viewed these services as helpful. Positive changes in education services were related to income (lower income received more services, p < .05) and parent satisfaction with the evaluation (p < .05). The intensity of special education services was strongly related to performance on state-based testing (p < .0001–p < .01).Conclusions: School response is a relatively objective and meaningful metric of educational outcome after neuropsychologically based evaluation for children with learning problems.
摘要目的:探讨跨学科、基于神经心理学的学习障碍小组评估后的教育效果。方法:137名儿童的父母在一到四年后完成了一项在线调查,这些儿童接受了基于学习问题的综合跨学科神经心理学评估。问题广泛地涉及到学校的结果:积极或消极的学校反应,特殊教育服务的变化,以及家长对这些服务的帮助的看法。这些结果与人口统计学特征和家长对评估的满意度有关。为了描述目的,我们还获得了最近在基于州的学术测试中的表现。结果:家长反映学校的反应普遍是积极的(78%),70%的家长表示他们的孩子在评估后获得了更多或不同的特殊教育服务。几乎一致(98%)的家长认为这些服务是有帮助的。教育服务的正向变化与收入(低收入者获得更多的服务,p < 0.05)和家长对评价的满意度相关(p < 0.05)。特殊教育服务的强度与州基础测试的表现密切相关(p < .0001 - p < .01)。结论:对有学习问题的儿童进行基于神经心理学的评估后,学校反应是一个相对客观和有意义的教育效果指标。
{"title":"Ascertaining educational outcomes after assessment in children with learning disorders","authors":"D. Waber, Ellen C. Boiselle, J. Girard, Joseph L. Amaral, P. Forbes","doi":"10.1080/13854046.2016.1244289","DOIUrl":"https://doi.org/10.1080/13854046.2016.1244289","url":null,"abstract":"Abstract Objective: To survey educational outcomes after an interdisciplinary, neuropsychologically based team assessment for learning disorders.Method: Parents of 137 children who underwent a comprehensive interdisciplinary neuropsychologically based assessment for learning problems completed an online survey one to four years later. Questions pertained broadly to school outcomes: positive or negative school responses, changes in special education services, and parental perceptions about the helpfulness of those services. These outcomes were examined in relation to demographic characteristics and parent satisfaction with the evaluation. We also obtained recent performance on state-based academic testing for descriptive purposes.Results: Parents reported that schools generally responded positively (78%), and 70% reported that their children had access to more or different special education services after the evaluation. Parents nearly uniformly (98%) viewed these services as helpful. Positive changes in education services were related to income (lower income received more services, p < .05) and parent satisfaction with the evaluation (p < .05). The intensity of special education services was strongly related to performance on state-based testing (p < .0001–p < .01).Conclusions: School response is a relatively objective and meaningful metric of educational outcome after neuropsychologically based evaluation for children with learning problems.","PeriodicalId":197334,"journal":{"name":"The Clinical neuropsychologist","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124771145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
List of Reviewers 审稿人名单
Pub Date : 2016-11-16 DOI: 10.1080/13854046.2016.1241374
{"title":"List of Reviewers","authors":"","doi":"10.1080/13854046.2016.1241374","DOIUrl":"https://doi.org/10.1080/13854046.2016.1241374","url":null,"abstract":"","PeriodicalId":197334,"journal":{"name":"The Clinical neuropsychologist","volume":"75 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126193322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
The Clinical neuropsychologist
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1