Purpose: The polymerization of restorative materials has the potential to increase pulpal temperature and may result in damage to the health of pulpal tissue. The aim of this study is to investigate the pulpal temperature change of primary teeth with two LED light-curing units (Valo Cordless®, EliparTM DeepCure-S) and three restorative groups (Filtek™ Bulk Fill Flowable, Filtek™ Z250 Universal Restorative and empty cavity) by using a microcirculation model. Material and Methods: Ten sound human maxillary second primary molars were used. Standardized Class V cavity preparations were performed with a dentin thickness of 1 mm and restorative groups were cured with LED light-curing units. The highest temperature point in the pulp chamber was recorded. A repeated measures ANOVA and paired samples t-test were used for analysis of the data (𝑝
目的:修复材料的聚合有可能使牙髓温度升高，对牙髓组织的健康造成损害。本研究通过微循环模型研究两种LED光固化单元(Valo Cordless®、EliparTM DeepCure-S)和三种修复组(Filtek™Bulk Fill Flowable、Filtek™Z250 Universal restorative和空腔)对乳牙牙髓温度变化的影响。材料与方法:选用10颗健全人上颌第二磨牙。采用标准的V级牙本质厚度为1mm的空腔制备，修复组采用LED光固化装置固化。记录了浆腔内的最高温度点。数据分析采用重复测量方差分析和配对样本t检验(𝑝)
{"title":"Effect of resin photopolymerization on primary teeth pulpal temperature change.","authors":"Y. Erdoğan, I. Ertuğrul","doi":"10.31362/patd.1257746","DOIUrl":"https://doi.org/10.31362/patd.1257746","url":null,"abstract":"Purpose: The polymerization of restorative materials has the potential to increase pulpal temperature and may result in damage to the health of pulpal tissue. The aim of this study is to investigate the pulpal temperature change of primary teeth with two LED light-curing units (Valo Cordless®, EliparTM DeepCure-S) and three restorative groups (Filtek™ Bulk Fill Flowable, Filtek™ Z250 Universal Restorative and empty cavity) by using a microcirculation model. \u0000Material and Methods: Ten sound human maxillary second primary molars were used. Standardized Class V cavity preparations were performed with a dentin thickness of 1 mm and restorative groups were cured with LED light-curing units. The highest temperature point in the pulp chamber was recorded. A repeated measures ANOVA and paired samples t-test were used for analysis of the data (𝑝","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":"142 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91110837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Purpose: The severe course of COVID-19 in individuals with chronic diseases has led to concerns in the management of rheumatic diseases during the pandemic therefore we aimed to define the factors associated with the frequency and severity of COVID-19 in patients with axial spondyloarthritis (axSpa) in this study. Materials-Methods: Patients with axSpa who were followed up in three tertiary hospitals and used their treatment regularly for at least six months were included. We assessed the relationship between axSpa associated variables such as disease duration time, radiological severity, treatment and COVID-19 outcomes. Results: A total of 833 patients with a mean disease duration of 109 months were analyzed; 64.5% had ankylosing spondylitis, 35.5% had non-radiographic axSpa diagnosis, and 59.4% of patients were treated with biologic agent . The frequency of COVID-19 was 23% (n: 192); only five pateints (0.5%) had a history of intensive care unit. Advanced age, hypertension (HT), and diabetes mellitus (DM) were found to be significantly more common in those with involvement in high resolution computed tomography (HRCT) (p:0.02, p:0.01, and p
{"title":"Factors associated with freqeuncy and severity of COVID-19 in patients with axial spondyloarthritis","authors":"M. Pekdiker, M. Kara, Emrah Koç, G. Kimyon","doi":"10.31362/patd.1223660","DOIUrl":"https://doi.org/10.31362/patd.1223660","url":null,"abstract":"Purpose: The severe course of COVID-19 in individuals with chronic diseases has led to concerns in the management of rheumatic diseases during the pandemic therefore we aimed to define the factors associated with the frequency and severity of COVID-19 in patients with axial spondyloarthritis (axSpa) in this study. \u0000Materials-Methods: Patients with axSpa who were followed up in three tertiary hospitals and used their treatment regularly for at least six months were included. We assessed the relationship between axSpa associated variables such as disease duration time, radiological severity, treatment and COVID-19 outcomes. \u0000Results: A total of 833 patients with a mean disease duration of 109 months were analyzed; 64.5% had ankylosing spondylitis, 35.5% had non-radiographic axSpa diagnosis, and 59.4% of patients were treated with biologic agent . The frequency of COVID-19 was 23% (n: 192); only five pateints (0.5%) had a history of intensive care unit. Advanced age, hypertension (HT), and diabetes mellitus (DM) were found to be significantly more common in those with involvement in high resolution computed tomography (HRCT) (p:0.02, p:0.01, and p","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73059234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Purpose: This study aimed to determine the relationship between the level of problematic internet use of adolescents and their level of satisfaction with family life. Method: The research was conducted in a cross-sectional descriptive design. 508 volunteer students from among the students studying at the high schools in Yozgat city center participated in the research which was carried out in the 2021-2022 academic year.. Data were collected through Google Forms questionnaires sent to students' smartphones. Results: The results of the analysis revealed a significant negative relationship between the problematic internet use of adolescents and their level of satisfaction with family life. Accordingly, a significant difference was determined between the variables of family income, academic achievement, father's educational background and father's child-rearing attitudes and problematic internet use. Furthermore, a significant difference was determined between the variables of academic achievement, parents’ living together, father's educational background, father's working status, family's economic income and the level of satisfaction with family life. Conclusion: In this study, the significance of the family with regard to the development of adolescents as healthy internet users was emphasized; it was suggested that preventive, protective and educational studies should be carried out and that the use of different methods, including other possible predictors, should be included in follow-up studies.
{"title":"The Relationship Between Problematic Internet Use of Adolescents and Their Level of Satisfaction with Family Life","authors":"Ayse Kalkan, Esin Cerit","doi":"10.31362/patd.1194209","DOIUrl":"https://doi.org/10.31362/patd.1194209","url":null,"abstract":"Purpose: This study aimed to determine the relationship between the level of problematic internet use of adolescents and their level of satisfaction with family life. \u0000Method: The research was conducted in a cross-sectional descriptive design. 508 volunteer students from among the students studying at the high schools in Yozgat city center participated in the research which was carried out in the 2021-2022 academic year.. Data were collected through Google Forms questionnaires sent to students' smartphones. \u0000Results: The results of the analysis revealed a significant negative relationship between the problematic internet use of adolescents and their level of satisfaction with family life. Accordingly, a significant difference was determined between the variables of family income, academic achievement, father's educational background and father's child-rearing attitudes and problematic internet use. Furthermore, a significant difference was determined between the variables of academic achievement, parents’ living together, father's educational background, father's working status, family's economic income and the level of satisfaction with family life. \u0000Conclusion: In this study, the significance of the family with regard to the development of adolescents as healthy internet users was emphasized; it was suggested that preventive, protective and educational studies should be carried out and that the use of different methods, including other possible predictors, should be included in follow-up studies.","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75175597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Erdal Görkem Gavcar, Ahmet Büber, Murat Balkıs, Çağlar Şimşek
Purpose: Numerous studies indicate that the use of smartphones among adolescents has increased recently. Studies on phubbing generally focus on how parental phubbing affects adolescents. This study aims to contribute to the literature by revealing the validity and reliability of the scale measuring phubbing behavior in adolescents. Material and Methods: The sample included 206 adolescents aged 12-17 who applied to Pamukkale University Medical Faculty Hospital Child and Adolescent Psychiatry Outpatient Clinics and Kırıkkale Yüksek İhtisas Hospital Child and Adolescent Psychiatry Outpatient Clinic. Results: To evaluate the construct validity of the General Phubbing Scale (GPS) in adolescents, first and second level confirmatory factor analyses were performed. The data model fit was shown to be at an acceptable level. The general phubbing was negatively related to social connectedness and positively related to internet addiction. Test-retest analysis indicated that the subdimensions nomophobia, interpersonal conflict, self-isolation, problem acceptance, and total score were 0.82, 0.80, 0.71, 0.66 and 0.81, respectively. The coefficients of internal consistency for the subdimensions of nomophobia, interpersonal conflict, self-isolation, problem acceptance, and total score were 0.78, 0.85, 0.92, 0.77, and 0.94. Furthermore, it has been shown that the GPS structure was identical for both genders. Conclusion: This study demonstrated that the GPS can be used as a valid and reliable measurement tool for determining general phubbing levels for the clinical adolescent sample.
目的:大量研究表明，最近青少年中智能手机的使用有所增加。关于低头症的研究通常集中在父母低头症对青少年的影响上。本研究旨在通过揭示青少年低头行为量表的效度和信度，为文献做出贡献。材料与方法:样本包括在Pamukkale大学医学院附属医院儿童与青少年精神病学门诊和Kırıkkale y ksek İhtisas附属医院儿童与青少年精神病学门诊就诊的206名12-17岁青少年。结果:采用一、二级验证性因子分析对青少年一般低头量表(GPS)的结构效度进行评价。数据模型拟合显示处于可接受的水平。一般的低头症与社会联系负相关，与网络成瘾正相关。重测分析显示，无恐惧症、人际冲突、自我隔离、问题接受和总分分别为0.82、0.80、0.71、0.66和0.81。无恐惧症子维度、人际冲突子维度、自我隔离子维度、问题接受子维度和总分的内部一致性系数分别为0.78、0.85、0.92、0.77和0.94。此外，研究表明，男女的GPS结构是相同的。结论:本研究表明GPS可以作为一种有效和可靠的测量工具，用于确定临床青少年样本的一般低头水平。
{"title":"The Psychometric Properties of the General Phubbing Scale in Adolescents","authors":"Erdal Görkem Gavcar, Ahmet Büber, Murat Balkıs, Çağlar Şimşek","doi":"10.31362/patd.1232372","DOIUrl":"https://doi.org/10.31362/patd.1232372","url":null,"abstract":"Purpose: Numerous studies indicate that the use of smartphones among adolescents has increased recently. Studies on phubbing generally focus on how parental phubbing affects adolescents. This study aims to contribute to the literature by revealing the validity and reliability of the scale measuring phubbing behavior in adolescents. \u0000 \u0000Material and Methods: The sample included 206 adolescents aged 12-17 who applied to Pamukkale University Medical Faculty Hospital Child and Adolescent Psychiatry Outpatient Clinics and Kırıkkale Yüksek İhtisas Hospital Child and Adolescent Psychiatry Outpatient Clinic. \u0000 \u0000Results: To evaluate the construct validity of the General Phubbing Scale (GPS) in adolescents, first and second level confirmatory factor analyses were performed. The data model fit was shown to be at an acceptable level. The general phubbing was negatively related to social connectedness and positively related to internet addiction. Test-retest analysis indicated that the subdimensions nomophobia, interpersonal conflict, self-isolation, problem acceptance, and total score were 0.82, 0.80, 0.71, 0.66 and 0.81, respectively. The coefficients of internal consistency for the subdimensions of nomophobia, interpersonal conflict, self-isolation, problem acceptance, and total score were 0.78, 0.85, 0.92, 0.77, and 0.94. Furthermore, it has been shown that the GPS structure was identical for both genders. \u0000 \u0000Conclusion: This study demonstrated that the GPS can be used as a valid and reliable measurement tool for determining general phubbing levels for the clinical adolescent sample.","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87444603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The aim of this study is to evaluate health status, erectile function, continence status and mental status of the patients. We also analyze demographic features and post-operative complications. We want to detect changings in surgical techniques and complication rates, so we will obtain accurate knowledges for the patients who will undergo radical prostatectomy in the future. 67 patient included to this study with permission of Pamukkale University ethic commission. We phoned patients and ask to come hospital to filling out forms and to ask few questiones. We suggest them to fill out generel health quality, IIEF, ICIQ and MMT forms. We also asked them how they decide to undergo operation, satisfaction and regret for treatment We record demographic and follow-up informations of patient from database of our hospital We found that the number of the patients who undergone radical prostatectomy increased over the years and the lenght of stay in hospital and the risk of additional operation for urethral stricture decreased over the yeary Data from our study were compatible with the existing literature- Çalışmamızın amacı kliniğimizde son 5 yılda yapılan radikal prostatektomi ameliyatlarının hastaların genel sağlık durumları, erektil fonksiyonları, kontinans durumları ve mental durumlarını değerlendirmek ayrıca hastaların demografik özellikleri ile post-operastif takiplerini retrospektif olarak değeılendirmektir. Bu değerlendirmeler sonucunda kliniğimizde yapılan radikal prostatektomi ameliyatlarının yıllar içinde teknik ve sonuçlar açısından değişimi saptanacak ayrıca önümüzdeki yıllarda bu ameliyatın önerileceği hasta grubuna sunulabilecek somut verilere ulaşılabilecektir. Çalışmaya Pamukkale Üniversitesi Tıbbi Etik kuruldan alınan izinle toplam 67 hasta dahil edildin Hastalar telefonla aranarak hastaneye çağıldı. Hastalara genel sağlık durumu, 11EF, ICIQ ve MMT sorgu formları uygulandı. Ayrıca hastalara operasyona karar aşamasındaki tutumları, tedavi memnuniyetleri ve aynı tedaviyi tekrar kabul edip etmeyecekleri soruldu„ Ardından hastaların operasyon ve operasyon sonrası takip bilgileri hastane hasta takip sisteminden kaydedildi, Çalışma kliniğimizin son 2 yılda radikal prostatektomi sayısında altış olduğu ayrıca vaka sayısında artışla birlikte hastaların hastanede kalış süıeleıinin ve darlık nedeniyle ek girişim riskinin azaldığı saptanmıştır. Çalışmamızdan elde edilen veriler mevcut literatür ile uyumlu saptanmıştır
本研究的目的是评估患者的健康状况、勃起功能、失禁状况和精神状况。我们还分析了人口统计学特征和术后并发症。我们希望发现手术技术和并发症发生率的变化，以便为将来接受根治性前列腺切除术的患者获得准确的知识。67例患者经Pamukkale大学伦理委员会同意纳入本研究。我们给病人打电话，让他们来医院填写表格，问一些问题。建议填写综合健康质量、IIEF、ICIQ和MMT表格。我们还询问他们是如何决定接受手术的，我们从我院数据库中记录患者的人口统计和随访信息，我们发现接受根治性前列腺切除术的患者数量逐年增加，住院时间和尿道狭窄额外手术的风险逐年下降。我们的研究数据与现有文献相符- Çalışmamızın amaci kliniğimizde son 5 yılda yapılan根治性前列腺切除术Ameliyatlarının hastaların genel sağlık durumlari, erektil fonksiyonlari, kontinans durumlari ve mental durumlarını değerlendirmek ayrıca hastaların demografik özellikleri ile post-operastif takiplerini retrospecktif olarak değeılendirmektir。但是değerlendirmeler sonucunda kliniğimizde yapılan radikal prostatektomi ameliyatlarının yıllar i - inde teknik ve sonucunda açısından değişimi saptanacak ayrıca önümüzdeki yıllarda但是ameliyatın önerileceği hasta grubuna sunulabilecek somut verilere ulaşılabilecektir。Çalışmaya Pamukkale Üniversitesi Tıbbi Etik kuruldan alınan izinle toplam 67 hasta dahil edildin Hastalar telefonla aranarak hastaneye çağıldı。Hastalara genel sağlık durumu, 11EF, ICIQ 5 MMT sorgu formlaryygulandi。埃尔ıca hastalara operasyona karar一şamaındaki tutumları,tedavi memnuniyetleri ve艾茵·ıtedaviyi tekrar喀布尔edip etmeyecekleri soruldu”Ardından hastaların operasyon ve operasyon sonrasıtakip bilgileri hastane直到takip sisteminden kaydedildi,卡尔ış马kliniğimizin儿子2 yılda radikal prostatektomi说ı年代ında altışolduğu埃尔ıca vaka说ı年代ında艺术ışla birlikte hastaların hastanede粗铁ış苏ı避署ıinin已经存在kınedeniyle ek girişim riskinin azaldığısaptanmıştır。Çalışmamızdan elde edilen veriler mecut literatr ile uumlu saptanmıştır
{"title":"Evaluation of quality of life and post-operative complications of our radical prostatectomy series for 5 years. 5 YILLIK RADİKAL PROSTATEKTOMİ SERİMİZİN POSTOPERATİF KOMPLİKASYON VE YAŞAM KALİTELERİNİN DEĞERLENDİRİLMESİ","authors":"Cihan Toktaş, I. Acar, Ö. L. Tuncay","doi":"10.31362/patd.1225431","DOIUrl":"https://doi.org/10.31362/patd.1225431","url":null,"abstract":"The aim of this study is to evaluate health status, erectile function, continence status and mental status of the patients. We also analyze demographic features and post-operative complications. We want to detect changings in surgical techniques and complication rates, so we will obtain accurate knowledges for the patients who will undergo radical prostatectomy in the future. \u000067 patient included to this study with permission of Pamukkale University ethic commission. We phoned patients and ask to come hospital to filling out forms and to ask few questiones. We suggest them to fill out generel health quality, IIEF, ICIQ and MMT forms. We also asked them how they decide to undergo operation, satisfaction and regret for treatment We record demographic and follow-up informations of patient from database of our hospital \u0000We found that the number of the patients who undergone radical prostatectomy increased over the years and the lenght of stay in hospital and the risk of additional operation for urethral stricture decreased over the yeary \u0000Data from our study were compatible with the existing literature- \u0000 \u0000 \u0000Çalışmamızın amacı kliniğimizde son 5 yılda yapılan radikal prostatektomi ameliyatlarının hastaların genel sağlık durumları, erektil fonksiyonları, kontinans durumları ve mental durumlarını değerlendirmek ayrıca hastaların demografik özellikleri ile post-operastif takiplerini retrospektif olarak değeılendirmektir. Bu değerlendirmeler sonucunda kliniğimizde yapılan radikal prostatektomi ameliyatlarının yıllar içinde teknik ve sonuçlar açısından değişimi saptanacak ayrıca önümüzdeki yıllarda bu ameliyatın önerileceği hasta grubuna sunulabilecek somut verilere ulaşılabilecektir. \u0000Çalışmaya Pamukkale Üniversitesi Tıbbi Etik kuruldan alınan izinle toplam 67 hasta dahil edildin Hastalar telefonla aranarak hastaneye çağıldı. Hastalara genel sağlık durumu, 11EF, ICIQ ve MMT sorgu formları uygulandı. Ayrıca hastalara operasyona karar aşamasındaki tutumları, tedavi memnuniyetleri ve aynı tedaviyi tekrar kabul edip etmeyecekleri soruldu„ Ardından hastaların operasyon ve operasyon sonrası takip bilgileri hastane hasta takip sisteminden kaydedildi, \u0000Çalışma kliniğimizin son 2 yılda radikal prostatektomi sayısında altış olduğu ayrıca vaka sayısında artışla birlikte hastaların hastanede kalış süıeleıinin ve darlık nedeniyle ek girişim riskinin azaldığı saptanmıştır. \u0000Çalışmamızdan elde edilen veriler mevcut literatür ile uyumlu saptanmıştır","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85333722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Göksu Hande Naz Şimdivar, Emine Çiloğlu, T. Incekalan, Neşe ÇETİN DOĞAN, Nevzat Ünal, Hivda ÜlbeĞİ Polat, E. Akçael
Purpose: To investigate the presence of virus in the aqueous humor and vitreous of patients undergoing elective combined cataract and pars plana vitrectomy during the Coronavirus disease 2019 (COVID-19) pandemic. Materials and methods: In this prospective cross-sectional study, of the patients to undergo elective surgery, those who had a negative severe acute respiratory syndrome coronavirus 2 ( SARS-CoV-2) nasal swab test 24-72 hours prior to the surgery and who were asymptomatic were included. SARS-CoV-2 IgG antibodies were evaluated in blood samples taken 24-72 hours before the operation. 0.1 cc of aqueous humor and 0.1 cc of vitreous fluid were aspirated at the beginning of the surgery. The presence of SARS-CoV-2 viral ribonucleic acid (RNA) was evaluated by real-time reverse transcriptase polymerase chain reaction (RT-PCR). Results: Of 66 participants, 39 were male (59.1%) while 27 were female (40.9%). Twenty five patients (37.8%) had a history of COVID-19 between 20 days - 60 days (mean 49 days) before the surgery. There were 58 patients (87.9%) with a history of vaccination before the operation and 8 patients (12.1%) without a history of vaccination. No SARS CoV 2 RNA was detected in the aqueous humor and vitreous samples of any patient. IgG against SARSCoV-2 was detected in 3 patients who had not been vaccinated against COVID-19 before and had no known history of COVID-19. Conclusion: We did not find any SARS-CoV-2 viral genetic material in the aqueous and vitreous fluids of asymptomatic participants whose nasal swab test was negative, even if they recently had COVID-19.
{"title":"Evaluation of the presence of SARS-CoV-2 in the aqueous humor and vitreous in patients undergoing combined phaco-vitrectomy surgery","authors":"Göksu Hande Naz Şimdivar, Emine Çiloğlu, T. Incekalan, Neşe ÇETİN DOĞAN, Nevzat Ünal, Hivda ÜlbeĞİ Polat, E. Akçael","doi":"10.31362/patd.1232525","DOIUrl":"https://doi.org/10.31362/patd.1232525","url":null,"abstract":"Purpose: To investigate the presence of virus in the aqueous humor and vitreous of patients undergoing elective combined cataract and pars plana vitrectomy during the Coronavirus disease 2019 (COVID-19) pandemic. \u0000Materials and methods: In this prospective cross-sectional study, of the patients to undergo elective surgery, those who had a negative severe acute respiratory syndrome coronavirus 2 ( SARS-CoV-2) nasal swab test 24-72 hours prior to the surgery and who were asymptomatic were included. SARS-CoV-2 IgG antibodies were evaluated in blood samples taken 24-72 hours before the operation. 0.1 cc of aqueous humor and 0.1 cc of vitreous fluid were aspirated at the beginning of the surgery. The presence of SARS-CoV-2 viral ribonucleic acid (RNA) was evaluated by real-time reverse transcriptase polymerase chain reaction (RT-PCR). \u0000Results: Of 66 participants, 39 were male (59.1%) while 27 were female (40.9%). Twenty five patients (37.8%) had a history of COVID-19 between 20 days - 60 days (mean 49 days) before the surgery. There were 58 patients (87.9%) with a history of vaccination before the operation and 8 patients (12.1%) without a history of vaccination. No SARS CoV 2 RNA was detected in the aqueous humor and vitreous samples of any patient. IgG against SARSCoV-2 was detected in 3 patients who had not been vaccinated against COVID-19 before and had no known history of COVID-19. \u0000Conclusion: We did not find any SARS-CoV-2 viral genetic material in the aqueous and vitreous fluids of asymptomatic participants whose nasal swab test was negative, even if they recently had COVID-19.","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84335047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Derya Karaer, Bahtiyar Şahinoğlu, A. Gürler, K. Karaer
Purpose: Familial Mediterranean Fever (FMF) is a hereditary auto inflammatory disease (MIM#249100). The most common symptoms are high fever, abdominal pain and arthralgia. FMF is the result of variations in the MEditerraneanFeVer (MEFV) gene, which is located on chromosome 16p13.3, consists of 10 exons and encodes the pyrin (marenostrin) protein. The frequency of MEFV gene variants that cause FMF varies according to ethnic groups, countries and even different regions in the same country. In this study, we aimed to determine the frequency and distribution of MEFV gene alterations that cause Familial Mediterranean fever in southeastern Turkey. Materials and Methods: A total of 6,660 patients with a prediagnosis of FMF, including 3,495 women and 3,165 men, were included in the study. Fragment analysis was performed to investigate the MEFV gene variations of the patients and the 19 most common variants in the Turkish population were examined. Results: We found at least one variation in 50.17% (3,341) of our 6,660 patients. In our patients, 108 different genotypes; in Exon 2, 3, 5 and 10 and we identified 16 different variations. We found 2,120 (63.21%) patients heterozygous, 693 (20.74%) compound heterozygotes, 275 (8.23%) homozygous and 261 (7.81%) complex genotypes. The 5 variants with the highest allele frequency are respectively; R202Q (27.84%), M694V (22.83%), E148Q (21.98%), V726A (7.42%), and M680I(G>C) (6.39%). Conclusion: We identified the most common prevalence of MEFV gene alteration in a large patient group in our region. High R202Q mutation rates were among the remarkable results of this study.
{"title":"Evaluation of the frequency of MEFV gene variants in patients with a pre-diagnosis of Familial Mediterranean Fever (FMF) in southeast Turkey.","authors":"Derya Karaer, Bahtiyar Şahinoğlu, A. Gürler, K. Karaer","doi":"10.31362/patd.1255344","DOIUrl":"https://doi.org/10.31362/patd.1255344","url":null,"abstract":"Purpose: Familial Mediterranean Fever (FMF) is a hereditary auto inflammatory disease (MIM#249100). The most common symptoms are high fever, abdominal pain and arthralgia. FMF is the result of variations in the MEditerraneanFeVer (MEFV) gene, which is located on chromosome 16p13.3, consists of 10 exons and encodes the pyrin (marenostrin) protein. The frequency of MEFV gene variants that cause FMF varies according to ethnic groups, countries and even different regions in the same country. In this study, we aimed to determine the frequency and distribution of MEFV gene alterations that cause Familial Mediterranean fever in southeastern Turkey. \u0000Materials and Methods: A total of 6,660 patients with a prediagnosis of FMF, including 3,495 women and 3,165 men, were included in the study. Fragment analysis was performed to investigate the MEFV gene variations of the patients and the 19 most common variants in the Turkish population were examined. \u0000Results: We found at least one variation in 50.17% (3,341) of our 6,660 patients. In our patients, 108 different genotypes; in Exon 2, 3, 5 and 10 and we identified 16 different variations. We found 2,120 (63.21%) patients heterozygous, 693 (20.74%) compound heterozygotes, 275 (8.23%) homozygous and 261 (7.81%) complex genotypes. The 5 variants with the highest allele frequency are respectively; R202Q (27.84%), M694V (22.83%), E148Q (21.98%), V726A (7.42%), and M680I(G>C) (6.39%). \u0000Conclusion: We identified the most common prevalence of MEFV gene alteration in a large patient group in our region. High R202Q mutation rates were among the remarkable results of this study.","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88322735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Purpose: Ischemic stroke is classified as large artery atherosclerosis, small vessel occlusion (lacunar infarcts), ischemic stroke due to other identified causes, and cryptogenic. The human leukocyte antigen (HLA) complex is a group of genes on chromosome six in humans responsible for encoding cell-surface proteins that regulate the immune system. In this study, HLA’s roles in the pathophysiology of ischemic stroke, especially the lacunar subgroup, are investigated, and their potential mechanisms are presented. Materials and methods: This study consisted of 49 patients with ischemic stroke and 50 healthy participants. HLA-A, HLA-B, HLA-C, HLA-DQB, and HLA-DRB subgroup genomes were assessed. Results: A statistically significant difference in the presence of HLA-A, HLA-B, HLA-C, HLA-DQB, and HLA-DRB subgroups was found between the control and patient groups. The presence of HLA-A*02, HLA-A*30, HLA-B*08, HLA-B*15, and HLA-DQB*06 genomes was higher in the patient group than in the control group (p≤0.05). Nevertheless, HLA-DQB*03 and HLA-DRB*11 genomes were found more in the control group than the patient group (p≤0.05) Conclusion: The results of this study pioneered in scrutinizing HLA alleles in small vascular disease (SVD). HLA-A*01, HLA-A*30, HLA-B*08, HLA-B*15, HLA-DQB*06, HLA-DQB*03 and HLA-DRB*11 are associated with HLA alleles of stroke patients with small vessel occlusion. We attempted to provide objective evidence for whether HLA genomes could act as a discriminative factor between SVD patients and control groups, which might hold considerable promise for future therapies.
目的:缺血性脑卒中分为大动脉粥样硬化、小血管闭塞(腔隙性梗死)、其他明确原因引起的缺血性脑卒中和隐源性脑卒中。人类白细胞抗原(HLA)复合物是人类6号染色体上的一组基因，负责编码调节免疫系统的细胞表面蛋白。本研究探讨了HLA在缺血性脑卒中病理生理中的作用，特别是腔隙亚群，并提出了其可能的机制。材料与方法:本研究包括49例缺血性脑卒中患者和50例健康受试者。评估HLA-A、HLA-B、HLA-C、HLA-DQB和HLA-DRB亚组基因组。结果:对照组与患者组之间HLA-A、HLA-B、HLA-C、HLA-DQB、HLA-DRB亚组的存在差异有统计学意义。患者组HLA-A*02、HLA-A*30、HLA-B*08、HLA-B*15、HLA-DQB*06基因组的存在率高于对照组(p≤0.05)。然而，HLA- dqb *03和HLA- drb *11基因组在对照组中比在患者组中发现的多(p≤0.05)。结论:本研究结果在小血管疾病(SVD) HLA等位基因的研究中具有开创性。HLA- a *01、HLA- a *30、HLA- b *08、HLA- b *15、HLA- dqb *06、HLA- dqb *03、HLA- drb *11与脑卒中合并小血管闭塞患者HLA等位基因相关。我们试图为HLA基因组是否可以作为SVD患者和对照组之间的判别因素提供客观证据，这可能为未来的治疗提供可观的希望。
{"title":"Relationship between cerebrovascular diseases and human leukocyte antigen subgroups","authors":"Ufuk Cinkir, Eylem Teke, E. Mete","doi":"10.31362/patd.1263788","DOIUrl":"https://doi.org/10.31362/patd.1263788","url":null,"abstract":"Purpose: Ischemic stroke is classified as large artery atherosclerosis, small vessel occlusion (lacunar infarcts), ischemic stroke due to other identified causes, and cryptogenic. The human leukocyte antigen (HLA) complex is a group of genes on chromosome six in humans responsible for encoding cell-surface proteins that regulate the immune system. In this study, HLA’s roles in the pathophysiology of ischemic stroke, especially the lacunar subgroup, are investigated, and their potential mechanisms are presented. \u0000Materials and methods: This study consisted of 49 patients with ischemic stroke and 50 healthy participants. HLA-A, HLA-B, HLA-C, HLA-DQB, and HLA-DRB subgroup genomes were assessed. \u0000Results: A statistically significant difference in the presence of HLA-A, HLA-B, HLA-C, HLA-DQB, and HLA-DRB subgroups was found between the control and patient groups. The presence of HLA-A*02, HLA-A*30, HLA-B*08, HLA-B*15, and HLA-DQB*06 genomes was higher in the patient group than in the control group (p≤0.05). Nevertheless, HLA-DQB*03 and HLA-DRB*11 genomes were found more in the control group than the patient group (p≤0.05) \u0000Conclusion: The results of this study pioneered in scrutinizing HLA alleles in small vascular disease (SVD). HLA-A*01, HLA-A*30, HLA-B*08, HLA-B*15, HLA-DQB*06, HLA-DQB*03 and HLA-DRB*11 are associated with HLA alleles of stroke patients with small vessel occlusion. We attempted to provide objective evidence for whether HLA genomes could act as a discriminative factor between SVD patients and control groups, which might hold considerable promise for future therapies.","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":"85 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79754544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Purpose: Colorectal cancers compose the third most common cancer group leading to death, with increasing rates in developed countries after lung and breast cancers. Rectal cancers make up about 30% of all colorectal cancers. Although many factors affecting recurrence and survival in rectal cancer have been identified, the stage of the tumor is the most important prognostic factor. However, many additional parameters that can be associated with survival and affect the adjuvant treatment plan have been identified besides the stage. Perineural invasion (PNI) is one of the parameters that can be associated with survival and affect the adjuvant treatment plan in colorectal cancers. The aim of this study is to investigate the effects of various histopathological prognostic factors, including PNI, on disease-free survival, overall survival, and recurrence rates in patients with rectal cancer who underwent surgery. Materials and methods: The clinical records of patients diagnosed with rectal cancer and operated on at the Department of General Surgery, Faculty of Medicine, Pamukkale University between 2008-2014 were reviewed. To investigate the factors affecting disease-free survival, recurrence rates, and overall survival, the presence of PNI, serum CEA levels, cTNM stage, pT stage, pN stage, number of metastatic LNs, tumor budding status, histopathological grades, lymphocyte infiltration, and presence of desmoplasia were evaluated in patients. Results: A total of 124 patients were included in the study. 42 patients (33.9%) had PNI while 82 patients (66.1%) did not have PNI. Of the 45 patients with recurrence, 26 had PNI while 19 did not have PNI. Of the 79 patients without recurrence, 16 had PNI while 63 did not have PNI. Similarly, PNI was seen more frequently in deaths related to the disease. The 3-year average survival of patients with and without PNI was 55% and 89%, respectively (p
{"title":"Investigation of the effect of perineural invasion on survival rates in rectal tumors.","authors":"U. Ozgen, U. Sungurtekin, N. Demirkan","doi":"10.31362/patd.1250890","DOIUrl":"https://doi.org/10.31362/patd.1250890","url":null,"abstract":"Purpose: Colorectal cancers compose the third most common cancer group leading to death, with increasing rates in developed countries after lung and breast cancers. Rectal cancers make up about 30% of all colorectal cancers. Although many factors affecting recurrence and survival in rectal cancer have been identified, the stage of the tumor is the most important prognostic factor. However, many additional parameters that can be associated with survival and affect the adjuvant treatment plan have been identified besides the stage. Perineural invasion (PNI) is one of the parameters that can be associated with survival and affect the adjuvant treatment plan in colorectal cancers. The aim of this study is to investigate the effects of various histopathological prognostic factors, including PNI, on disease-free survival, overall survival, and recurrence rates in patients with rectal cancer who underwent surgery. Materials and methods: The clinical records of patients diagnosed with rectal cancer and operated on at the Department of General Surgery, Faculty of Medicine, Pamukkale University between 2008-2014 were reviewed. To investigate the factors affecting disease-free survival, recurrence rates, and overall survival, the presence of PNI, serum CEA levels, cTNM stage, pT stage, pN stage, number of metastatic LNs, tumor budding status, histopathological grades, lymphocyte infiltration, and presence of desmoplasia were evaluated in patients. \u0000Results: A total of 124 patients were included in the study. 42 patients (33.9%) had PNI while 82 patients (66.1%) did not have PNI. Of the 45 patients with recurrence, 26 had PNI while 19 did not have PNI. Of the 79 patients without recurrence, 16 had PNI while 63 did not have PNI. Similarly, PNI was seen more frequently in deaths related to the disease. The 3-year average survival of patients with and without PNI was 55% and 89%, respectively (p","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":"54 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72646489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Purpose: To evaluate the outcomes of the closure of the appendix base using two different suture materials that we used in our clinic with those published in the literature. Materials and methods: The study retrospectively reviews 36 cases of children who underwent laparoscopic appendectomies. The patients were divided into two groups: the Vicryl suture group and the silk suture group. Laboratory results, diagnostic algorithms, surgical techniques, and complications were investigated. Results: Sixteen (44%) of the cases were male, and twenty (56%) were female. All patients' mean hospital admission time was 2.22±1.6 days (range: 1–7 days). The mean WBC and CRP levels were 14.67±5.8x109/L, 139.3±120 mg/L in the vicryl group and 15.36±6.4x109/L and 86±80 mg/L in the silk group. Small bowel obstruction was observed in nine patients in the vicryl group and six patients in the silk group. Ultrasonography was performed in 31 of the cases, the appendix was visualized in 21 cases (67%).Intravenous contrast-enhanced CT imaging was applied in 25 cases. At laparoscopic exploration, 20 cases were classified as complicated—17 due to perforation, and 3 due to gangrene. All cases were treated with broad-spectrum antibiotics. The mean follow-up period was 43 months (range: 10-117 months); none of the patients experienced intraoperative complications, and only two patients had minor complications in the postoperative period. Conclusion: In all circumstances and regardless of the appendix's diameter, the appendix stump can be securely closed with both silk and vicryl suture material.
{"title":"Closure of the appendix stump with two different suture materials in laparoscopic appendectomy in children","authors":"Osman Uzunlu","doi":"10.31362/patd.1249448","DOIUrl":"https://doi.org/10.31362/patd.1249448","url":null,"abstract":"Purpose: To evaluate the outcomes of the closure of the appendix base using two different suture materials that we used in our clinic with those published in the literature. \u0000 \u0000Materials and methods: The study retrospectively reviews 36 cases of children who underwent laparoscopic appendectomies. The patients were divided into two groups: the Vicryl suture group and the silk suture group. Laboratory results, diagnostic algorithms, surgical techniques, and complications were investigated. \u0000 \u0000Results: \u0000Sixteen (44%) of the cases were male, and twenty (56%) were female. All patients' mean hospital admission time was 2.22±1.6 days (range: 1–7 days). The mean WBC and CRP levels were 14.67±5.8x109/L, 139.3±120 mg/L in the vicryl group and 15.36±6.4x109/L and 86±80 mg/L in the silk group. Small bowel obstruction was observed in nine patients in the vicryl group and six patients in the silk group. Ultrasonography was performed in 31 of the cases, the appendix was visualized in 21 cases (67%).Intravenous contrast-enhanced CT imaging was applied in 25 cases. At laparoscopic exploration, 20 cases were classified as complicated—17 due to perforation, and 3 due to gangrene. All cases were treated with broad-spectrum antibiotics. The mean follow-up period was 43 months (range: 10-117 months); none of the patients experienced intraoperative complications, and only two patients had minor complications in the postoperative period. \u0000 \u0000Conclusion: In all circumstances and regardless of the appendix's diameter, the appendix stump can be securely closed with both silk and vicryl suture material.","PeriodicalId":19789,"journal":{"name":"Pamukkale Medical Journal","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72884251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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