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Intravenous thrombolytic therapies in the management of unknown onset and wakeup strokes: A scoping review 静脉溶栓治疗在不明起病和醒后卒中中的应用:范围综述
Pub Date : 2022-12-04 DOI: 10.56310/pjns.v17i02.184
Saima Nazish
Background : The efficacy and safety of thrombolytic therapies for the management of unknown time onset stroke (UTOS) and wake-up stroke (WUS) are in a debate.  Objective: The objective of this scoping review is to map the existing research literature to answer the research question: What is the efficacy and safety of intravenous thrombolysis in the management of unknown time onset stroke?  Data Sources:  The literature search was conducted using the search terms {(Intravenous thrombolysis)} AND {(Unknown time onset stroke)} in pub med and Intravenous thrombolysis *, Unknown time onset stroke *in Cochrane. The review was limited to articles written in the English language. Databases searched included MEDLINE, PubMed and Cochrane electronic databases complemented with a manual search. Study Selection and Data Extraction: 45 articles of potential relevance were selected. Out of them 14 were containing relevant information direct to the question. The analysis was conducted by charting descriptive numerical data and by content analysis of the narrative representations  Results:  From 14 relevant papers, 2 Retrospective observational, 2 case control, 1 pilot study, and 5 recent randomized control trials were included for critical appraisal and review writing. Conclusions:  The penumbral mismatch in UTOS is a cogent method to recognize the patients for thrombolytic therapy without significant risk, but the appropriate imaging criteria to maximize the efficacy and minimize bleeding complications of thrombolytic treatment still has to be fully defined. Results from ongoing trials may be promising with the use of advanced imaging modalities in selected patients.
背景:溶栓治疗治疗未知时间起脑卒中(UTOS)和唤醒性脑卒中(WUS)的有效性和安全性一直存在争议。目的:本综述的目的是对现有的研究文献进行梳理,以回答研究问题:静脉溶栓治疗时间不明的脑卒中的有效性和安全性是什么?资料来源:文献检索采用pubmed检索词{(静脉溶栓)}和{(未知时间起脑卒中)},Cochrane检索词静脉溶栓*,未知时间起脑卒中*。该综述仅限于用英语撰写的文章。检索的数据库包括MEDLINE、PubMed和Cochrane电子数据库,并辅以人工检索。研究选择和数据提取:选择45篇具有潜在相关性的文章。其中14个包含直接与问题相关的信息。结果:从14篇相关论文中,纳入2篇回顾性观察性研究、2篇病例对照研究、1篇先导性研究和5篇近期随机对照试验,进行批判性评价和综述写作。结论:UTOS的半影失配是识别溶栓治疗患者的可靠方法,无明显风险,但如何制定合适的影像学标准以最大限度地提高溶栓治疗的疗效,最大限度地减少溶栓治疗的出血并发症仍有待明确。正在进行的试验结果可能是有希望的使用先进的成像方式在选定的患者。
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引用次数: 0
Churg Strauss syndrome with neuropathy: a case report 丘格·施特劳斯综合征伴神经病变1例
Pub Date : 2022-12-04 DOI: 10.56310/pjns.v17i02.182
Zaid Waqar
A 24 years old man with known history of asthma came with acute presentation of ascending weakness for4 days following flu like symptoms and worsening of asthma. His complete blood counts showed elevated eosinophil count. Nerve conduction showed neuropathy. Diagnosed Churg Strauss syndrome due to presence of asthma, eosinophilia, neuropathy and pulmonary infiltrates. Churg Strauss is systemic eosinophilic vasculitis involving multiple organ systems.
24岁男性,已知有哮喘病史,在流感样症状和哮喘恶化后出现急性虚弱4天。他的全血细胞计数显示嗜酸性粒细胞计数升高。神经传导表现为神经病。由于哮喘、嗜酸性粒细胞增多、神经病变和肺部浸润,诊断为Churg Strauss综合征。Churg Strauss是累及多器官系统的系统性嗜酸性血管炎。
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引用次数: 0
Molecular analyses of Phenylketonuria in the intellectually disabled children from Faisalabad, Punjab, Pakistan 巴基斯坦旁遮普费萨拉巴德智障儿童苯丙酮尿的分子分析
Pub Date : 2022-12-04 DOI: 10.56310/pjns.v17i02.168
Habiba Hussain, M. Wasim, Haq Nawaz Khan, Hina Ayesha, Fazli Rabbi Awan
Background: Phenylketonuria (PKU) is a rare inherited metabolic disorder, caused by mutations in the phenylalanine hydroxylase (PAH). It is a treatable disorder if diagnosed earlier in life. The objective was to identify PKU patient(s) in the intellectually disabled children. Methods: Blood samples (n=100) were collected from intellectually disabled children from Faisalabad, Pakistan. Screening was performed on plasma samples through HPLC, and DNA samples were examined for mutational analysis of PAH through direct PCR and SSCP analyses. Results: 85% consanguinity rate, the average BMI (16.15 kg/m2) and head circumference (50.21 cm) was observed. Moreover, through biochemical and genetic analyses, not a single PKU patient was identified. Conclusion: Based on just one previous report and our small dataset it is concluded that either mutations are not common in the hotspot regions or chances of occurrence of PKU might be rare in Pakistan. Moreover, there is a need of more research on large scale to find the incidence of PKU in Pakistan.
背景:苯丙酮尿症(PKU)是一种罕见的遗传性代谢疾病,由苯丙氨酸羟化酶(PAH)突变引起。如果在生命早期诊断出来,这是一种可以治疗的疾病。目的是在智障儿童中识别PKU患者。方法:采集巴基斯坦费萨拉巴德市智障儿童血样100例。通过HPLC对血浆样本进行筛选,通过直接PCR和SSCP分析对DNA样本进行PAH突变分析。结果:血亲率85%,平均BMI (16.15 kg/m2),头围(50.21 cm)。此外,通过生化和基因分析,没有一个PKU患者被确定。结论:仅基于先前的一份报告和我们的小数据集,我们得出的结论是,突变在热点地区并不常见,或者PKU的发生机会在巴基斯坦可能很少见。此外,还需要更多的大规模研究来了解巴基斯坦的PKU发病率。
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引用次数: 1
Post COVID-19 vaccine (SINOVAC) cerebral venous sinus thrombosis 新冠肺炎疫苗后脑静脉窦血栓形成
Pub Date : 2022-12-03 DOI: 10.56310/pjns.v17i02.185
Soban Khan, Mariam Khalil, Zaid Waqar
Sinovac is an inactivated virus COVID 19 vaccine given emergency authorization for COVID 19 Pandemic.  Different adverse reactions have been seen in after marketing of COVID 19 vaccines. Here we present a case of patient who developed cerebral venous sinus thrombosis two weeks after the first dose of SINOVAC vaccine.
科兴是一种COVID - 19灭活病毒疫苗,获得了COVID - 19大流行紧急授权。COVID - 19疫苗上市后出现了不同的不良反应。在此,我们报告一例患者在首次注射SINOVAC疫苗后两周发生脑静脉窦血栓形成。
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引用次数: 1
Prevalence of depression in caregivers of stroke patients in Karachi, Pakistan 巴基斯坦卡拉奇卒中患者护理人员抑郁患病率
Pub Date : 2022-12-02 DOI: 10.56310/pjns.v17i02.192
Marium Mansoor, S. Pirani, Rabeeka Aftab, Tania Nadeem
OBJECTIVES To determine the frequency of depression in caregivers of stroke patients at a tertiary care teaching hospital in Karachi Pakistan.  METHODS A cross-sectional study was conducted among caregivers of stroke, who were recruited from the Aga Khan University Hospital Karachi Pakistan, between January 2018 to October 2018. Data was collected through the Urdu Hamilton rating scale for depression (HAM-D-U) and it was analyzed using descriptive and inferential statistics.  RESULTS A total of 136 caregivers participated in the study. Among them, 44.1 % were male and 55.9% were female. The mean age of caregivers was 45.38 ± 10.33 years. Using the HAM-D-U scale, depression was present in 64 (47.1%) caregivers. Out of them (n=64), 46 (33.8%) caregivers had mild depression whereas 18 (13.2%) had moderate depression. Depression was found to have a significant relationship with the age of the patient (p=0.002), education level of caregiver (p= 0.012), employment status of caregiver (p=0.012), being a sole caregiver (p=0.039), and monthly family income (p=0.016).  CONCLUSIONS Caring for patients with neurological disorders is highly challenging and demanding. The need for this role may arise unexpectedly in one’s life; leaving little space for adjustment and coping. Depression itself can be very paralyzing for the sufferer especially if moderate to severe in intensity. Depression in stroke caregivers can be missed as patients are the center of a clinical visit. Hence, strategies should be designed and reinforced to screen patients and caregivers for depression along with a pathway for an easy and timely referral.
目的了解巴基斯坦卡拉奇某三级护理教学医院脑卒中患者护理人员抑郁发生率。方法在2018年1月至2018年10月期间从巴基斯坦卡拉奇阿迦汗大学医院招募的中风护理人员中进行横断面研究。通过乌尔都汉密尔顿抑郁量表(HAM-D-U)收集数据,并采用描述性统计和推理统计进行分析。结果共136名护理人员参与本研究。其中男性占44.1%,女性占55.9%。护理人员平均年龄45.38±10.33岁。使用HAM-D-U量表,64名(47.1%)照顾者存在抑郁。其中(n=64), 46名(33.8%)护理人员患有轻度抑郁症,18名(13.2%)患有中度抑郁症。抑郁症与患者年龄(p=0.002)、照顾者文化程度(p=0.012)、照顾者就业状况(p=0.012)、独自照顾者(p=0.039)、家庭月收入(p=0.016)有显著关系。结论:护理神经系统疾病患者是一项极具挑战性和高要求的工作。对这个角色的需求可能会在一个人的生活中意外出现;没有留下多少调整和应对的空间。抑郁症本身对患者来说是非常瘫痪的,尤其是在中度到重度的情况下。由于患者是临床访问的中心,中风护理人员可能会忽略抑郁症。因此,应该设计和加强策略来筛选抑郁症患者和护理人员,并提供一个简单和及时的转诊途径。
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引用次数: 1
Practical measures for disabled’s empowerment- Time for economic growth! 残疾人赋权的实际措施——经济增长的时间到了!
Pub Date : 2022-12-02 DOI: 10.56310/pjns.v17i02.195
M. Hafeez
   The objective of this paper is to advocate for Persons with disabilities’ (PWD) rights, to discuss issues solutions, social awareness and to promote diversity and inclusion.       The word ‘Disability’ covers a wide range of irreversible permanent impairments including physical and mobility difficulties, hearing, visual impairment, specific learning disabilities including dyslexia, medical conditions and mental health problems that may hinder their full and effective participation in society on an equal basis with others.1 Handicap is the condition of being unable to perform due to physical or mental unfitness.
本文的目的是倡导残疾人士的权利,讨论问题的解决方案,提高社会意识,促进多元化和共融。“残疾”一词涵盖范围广泛的不可逆转的永久性损伤,包括身体和行动困难、听力、视力障碍、包括阅读障碍在内的特殊学习障碍、医疗状况和精神健康问题,这些都可能妨碍残疾人在与其他人平等的基础上充分和有效地参与社会残疾是指由于身体或精神不健康而不能参加比赛的状况。
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引用次数: 0
A case of ulcerative colitis presenting with cerebral venous thrombosis 溃疡性结肠炎并发脑静脉血栓1例
Pub Date : 2022-10-18 DOI: 10.56310/pjns.v17i01.177
Zaid Waqar
Ulcerative Colitis is an autoimmune Inflammatory Bowel Disease causing abdominal pain, bloody diarrhea and malnutrition and is associated with Intestinal and extra intestinal complications. The clinical course has remissions and flare ups. Thromboembolism is known risk associated with Ulcerative colitis. Here we present a case of a young man who presented with a flare up of ulcerative colitis and developed neurological deficits that were diagnosed as due to cerebral venous thrombosis. Cerebral venous thrombosis is rare complications rare complication of ulcerative colitis and maybe missed without proper work up and consideration of diagnosis.
溃疡性结肠炎是一种自身免疫性炎症性肠病,引起腹痛、血性腹泻和营养不良,并与肠道和肠道外并发症有关。临床过程有缓解和突然发作。已知血栓栓塞与溃疡性结肠炎相关。在这里,我们提出了一个年轻人的情况下,谁提出了溃疡性结肠炎和发展的神经功能障碍,被诊断为由于脑静脉血栓形成。脑静脉血栓形成是溃疡性结肠炎的罕见并发症,如果不及时检查和诊断,可能会被遗漏。
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引用次数: 0
World Brain Day- brain health for all 世界大脑日——人人享有大脑健康
Pub Date : 2022-10-18 DOI: 10.56310/pjns.v17i01.190
S. Younis
World Brain Day is celebrated annually on July 22nd,  and this year’s theme was “Brain Health for All”. In honor of World Brain Day, Aga Khan University, in collaboration with the World Federation of Neurology, hosted an international webinar. This article summarizes the main proceedings and expounds upon key takeaways. 
每年的7月22日是世界大脑日,今年的主题是“人人享有大脑健康”。为了纪念世界大脑日,阿迦汗大学与世界神经病学联合会合作,举办了一次国际网络研讨会。本文总结了主要的研究过程,并对主要结论进行了阐述。
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引用次数: 0
Stroke: Are women worse off? 中风:女性的情况更糟吗?
Pub Date : 2022-10-18 DOI: 10.56310/pjns.v17i01.159
Maria Khan
This is a short communication on new information emerging about stroke in women
这是一个关于女性中风新信息的简短交流
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引用次数: 0
Misperception about epilepsy among common public in Balochistan 俾路支省公众对癫痫的误解
Pub Date : 2022-10-18 DOI: 10.56310/pjns.v17i01.165
Muhammad Essa, Gulandam, Aman ullah Kakar, Saleem Barech, Ihsan ul haq zarkon, Suhail Mari, Muhammad Dawood, Tahir Shah
Abstract Background of the Study: Epilepsy is a curable chronic neurological illness that is frequently associated to supernatural activity. Due to a lack of knowledge and awareness among the Common public. The objectives of this study were to determine common myths and misperception about epilepsy by analysing a comprehensive panel of variables in our local population. Methods: We conducted a face-to-face questionnaire interview survey in three different shopping malls 1000 people were randomly enrolled in this cross-sectional study at Quetta, Baluchistan, during the period of twenty-one august 2021 to 30 august 2021. Results: A total of 1000 people were interviewed among them 220(22%) were male and 780(78%) were female. People of all age group were included in the study. Out of thousand people 419 (41.9%) says epilepsy is brain disease, 488 (48.8%) responds its ghost attack, 23(2.3%) believes its psychosis. 980(98%) respondents had heard about epilepsy. The aspects of knowledge tested were on causes, types, and management of epilepsy. Forty-nine (4.9%) people believes that cause of epilepsy is head trauma, 488 (48.8%) said its Ghost attack, 67 (6.7%) said it’s because of evil eye, and 293 (29.3%) peoples believes that epilepsy is caused by Black magic. 928 (92.8%) who believed on domestic stunts such as sniffing shoes is effective in epilepsy. This result was much surprising because in this era of modern medicine and technology, still superstitious believes prevail among large population Conclusions: This study revealed a lack of awareness about epilepsy in Baluchistan, as well as the prevalence of both negative and favourable attitudes about Epilepsy. The study also emphasized to increase public awareness and epilepsy education initiatives to change public opinions and promote the use of standard epileptic treatment Keywords: Epilepsy, Attitudes, Knowledge
摘要研究背景:癫痫是一种可治愈的慢性神经系统疾病,通常与超自然活动有关。由于普通大众缺乏知识和意识。本研究的目的是通过分析我们当地人群的综合变量来确定关于癫痫的常见神话和误解。方法:在2021年8月21日至2021年8月30日期间,我们在俾路支省奎达的三个不同的购物中心进行了面对面的问卷访谈调查,随机招募了1000人参加这项横断面研究。结果:共访谈1000人,其中男性220人(22%),女性780人(78%)。所有年龄段的人都参与了这项研究。每千人中有419人(41.9%)认为癫痫病是脑部疾病,488人(48.8%)认为癫痫病是鬼魂发作,23人(2.3%)认为癫痫病是精神病。980名(98%)受访者听说过癫痫。知识测试的方面是癫痫的原因、类型和管理。49人(4.9%)认为癫痫的病因是头部外伤,488人(48.8%)认为是鬼的袭击,67人(6.7%)认为是邪眼,293人(29.3%)认为癫痫是黑魔法引起的。928人(92.8%)认为嗅鞋等国产噱头对癫痫有效。这一结果非常令人惊讶,因为在这个现代医学和技术的时代,迷信信仰仍然在大量人口中盛行。结论:本研究揭示了俾路支省对癫痫缺乏认识,以及对癫痫的消极和积极态度的普遍存在。本研究还强调要提高公众意识,开展癫痫教育活动,改变公众观念,促进使用标准的癫痫治疗方法
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引用次数: 0
期刊
Pakistan Journal of Neurological Sciences
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