首页 > 最新文献

Pathologia et microbiologia最新文献

英文 中文
Skeletal effects of cholesterol feeding. 摄入胆固醇对骨骼的影响。
Pathologia et microbiologia
Pub Date : 1975-01-01 DOI: 10.1159/000162839
R Silberberg

The effect of a 4% supplement of cholesterol to a standard diet on knee joints and vertebral columns was investigated in male mice of strain C57B1. The experimental diet was fed from the time of weaning through the 18-month period of observation or from the age of 1 year to the end of the experiment at 18 months of age. The incidence of osteoarthrosis was increased in mice fed cholesterol from the age of 12 months on. The incidence of spondylosis was increased after lifelong feeding as well as after feeding of cholesterol during the second year of life. This increase involved both, spondylosis associated with or uncomplicated by prolapse of intervertebral discs. The incidence of simple disc prolapse was not affected by the experimental diet.

研究了C57B1品系雄性小鼠在标准饮食中补充4%胆固醇对膝关节和脊柱的影响。试验饲粮从断奶时开始饲喂至观察期18个月，或1岁饲喂至18个月试验结束。从12个月大时起，喂食胆固醇的小鼠骨关节病的发病率增加。脊椎病的发病率在终生喂食后以及在出生后第二年喂食胆固醇后都有所增加。这种增加包括两种情况，伴有或不伴有椎间盘突出的颈椎病。单纯性椎间盘脱垂的发生率不受实验饮食的影响。
{"title":"Skeletal effects of cholesterol feeding.","authors":"R Silberberg","doi":"10.1159/000162839","DOIUrl":"https://doi.org/10.1159/000162839","url":null,"abstract":"<p><p>The effect of a 4% supplement of cholesterol to a standard diet on knee joints and vertebral columns was investigated in male mice of strain C57B1. The experimental diet was fed from the time of weaning through the 18-month period of observation or from the age of 1 year to the end of the experiment at 18 months of age. The incidence of osteoarthrosis was increased in mice fed cholesterol from the age of 12 months on. The incidence of spondylosis was increased after lifelong feeding as well as after feeding of cholesterol during the second year of life. This increase involved both, spondylosis associated with or uncomplicated by prolapse of intervertebral discs. The incidence of simple disc prolapse was not affected by the experimental diet.</p>","PeriodicalId":19854,"journal":{"name":"Pathologia et microbiologia","volume":"43 4","pages":"265-75"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000162839","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12405467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Endocarditis parietalis eosinophilica-are there idiopathic forms? 壁性心内膜炎嗜酸性粒细胞增多——有特发性形式吗?
Pathologia et microbiologia
Pub Date : 1975-01-01 DOI: 10.1159/000162802
T Hardmeier, H P Biedermann, H L Winklehner
{"title":"Endocarditis parietalis eosinophilica-are there idiopathic forms?","authors":"T Hardmeier,&nbsp;H P Biedermann,&nbsp;H L Winklehner","doi":"10.1159/000162802","DOIUrl":"https://doi.org/10.1159/000162802","url":null,"abstract":"","PeriodicalId":19854,"journal":{"name":"Pathologia et microbiologia","volume":"43 2-O","pages":"107-13"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000162802","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12405582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Medionecrosis aortae. 主动脉中微血管病。
Pathologia et microbiologia
Pub Date : 1975-01-01 DOI: 10.1159/000162806
A E Becker
{"title":"Medionecrosis aortae.","authors":"A E Becker","doi":"10.1159/000162806","DOIUrl":"https://doi.org/10.1159/000162806","url":null,"abstract":"","PeriodicalId":19854,"journal":{"name":"Pathologia et microbiologia","volume":"43 2-O","pages":"124-8"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000162806","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12405586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Natural history of primary lymphedema of the legs. 腿部原发性淋巴水肿的自然病史。
Pathologia et microbiologia
Pub Date : 1975-01-01 DOI: 10.1159/000162826
U Brunner
{"title":"Natural history of primary lymphedema of the legs.","authors":"U Brunner","doi":"10.1159/000162826","DOIUrl":"https://doi.org/10.1159/000162826","url":null,"abstract":"","PeriodicalId":19854,"journal":{"name":"Pathologia et microbiologia","volume":"43 2-O","pages":"230-234"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000162826","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12417468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
F antigen. II. Chemical and physical properties. F抗原。2化学和物理性质。
Pathologia et microbiologia
Pub Date : 1975-01-01 DOI: 10.1159/000162716
R. Utzinger
Physical and chemical properties of the liver-specific F antigen suggested a model for the labile quarternary structure of the protein. The native molecule showed a size slightly larger than 60,000 dalton (d), which was reduced to about 40,000 d under acidic conditions. Breaking of hydrogen bonds by chaotropic treatment resulted in the release of components of 30,000, 7,000 and 2,000 d. The smallest component was split to fragments of about 1,000 d by the reducing action of sulfhydryl compounds.
肝脏特异性F抗原的物理和化学性质为该蛋白的不稳定的四级结构提供了一个模型。天然分子的尺寸略大于60,000道尔顿(d)，在酸性条件下减小到40,000 d左右。朝乱性处理导致氢键断裂，释放30,000、7,000和2,000 d的组分。最小的组分在巯基化合物的还原作用下被分裂成约1,000 d的片段。
{"title":"F antigen. II. Chemical and physical properties.","authors":"R. Utzinger","doi":"10.1159/000162716","DOIUrl":"https://doi.org/10.1159/000162716","url":null,"abstract":"Physical and chemical properties of the liver-specific F antigen suggested a model for the labile quarternary structure of the protein. The native molecule showed a size slightly larger than 60,000 dalton (d), which was reduced to about 40,000 d under acidic conditions. Breaking of hydrogen bonds by chaotropic treatment resulted in the release of components of 30,000, 7,000 and 2,000 d. The smallest component was split to fragments of about 1,000 d by the reducing action of sulfhydryl compounds.","PeriodicalId":19854,"journal":{"name":"Pathologia et microbiologia","volume":"12 1","pages":"3-14"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90631425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
F antigen. III. Immunological and biological properties. F抗原。3免疫学和生物学特性。
Pathologia et microbiologia
Pub Date : 1975-01-01 DOI: 10.1159/000162727
R. Utzinger
Relationship of the isoforms of F antigens from A2G and CBA inbred mouse strains have been worked out in detail in respect to their immunogenicity. Mice from several inbred strains have been shown to possess the ability of forming anti-F upon stimulation with xenogeneic F antigens from certain species. An immunoelectrophoretic method for sensitive quantitation of the antigen is described. During human ontogenesis the antigen appears very early. It could never be detected in serum except in cases of acute liver disease. A small fragment set free under denaturing conditions showed the ability of inhibiting precipitation of the complete antigen by antibody. The F protein seems to be a vehicle for this small fragment possessing haptenic properties and probably being responsible for the universal cross-reactivity.
详细分析了A2G和CBA近交系小鼠F抗原同工型在免疫原性方面的关系。来自几个近交系的小鼠已被证明在受到来自某些物种的异种F抗原刺激时具有形成抗F的能力。描述了一种抗原敏感定量的免疫电泳方法。在人类个体发育过程中，抗原很早就出现了。除非在急性肝病的情况下，它永远不能在血清中检测到。在变性条件下释放的小片段显示出抑制抗体沉淀完整抗原的能力。F蛋白似乎是这个具有半抗原特性的小片段的载体，可能是造成普遍交叉反应的原因。
{"title":"F antigen. III. Immunological and biological properties.","authors":"R. Utzinger","doi":"10.1159/000162727","DOIUrl":"https://doi.org/10.1159/000162727","url":null,"abstract":"Relationship of the isoforms of F antigens from A2G and CBA inbred mouse strains have been worked out in detail in respect to their immunogenicity. Mice from several inbred strains have been shown to possess the ability of forming anti-F upon stimulation with xenogeneic F antigens from certain species. An immunoelectrophoretic method for sensitive quantitation of the antigen is described. During human ontogenesis the antigen appears very early. It could never be detected in serum except in cases of acute liver disease. A small fragment set free under denaturing conditions showed the ability of inhibiting precipitation of the complete antigen by antibody. The F protein seems to be a vehicle for this small fragment possessing haptenic properties and probably being responsible for the universal cross-reactivity.","PeriodicalId":19854,"journal":{"name":"Pathologia et microbiologia","volume":"27 1","pages":"92-102"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88748477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemical carcinogenesis in the hamster cheek pouch. Influence of inhibitors and inducers of alkaline phosphatase. 仓鼠颊袋的化学致癌作用。抑制剂和诱导剂对碱性磷酸酶的影响。
Pathologia et microbiologia
Pub Date : 1975-01-01
D Rubin, I S Levij

Squamous cell carcinomas were induced in the hamster cheek pouch with 9,10-dimethyl-1,2-benzanthracene. The process of carcinogenesis was inhibited by phenylphosphate, an inducer of alkaline phosphatase. Orthophosphate and l-phenylalanine, which inhibit alkaline phosphatase, had a promoting effect on tumor formation. The results are in accordance with those of previous studies on the effect of inducers of alkaline phosphatase on chemical carcinogenesis. The effect of the studied substances on carcinogenesis was apparently unrelated to the presence of phenyl or phosphate groups or of steroid rings. The tumor inhibition or promotion seemed to be related to the potential of the tested substances to induce or inhibit alkaline phosphatase activity.

9,10-二甲基-1,2-苯并蒽在仓鼠颊袋中诱导鳞状细胞癌。碱性磷酸酶诱导剂苯基磷酸抑制了肿瘤的癌变过程。抑制碱性磷酸酶的正磷酸盐和l-苯丙氨酸对肿瘤形成有促进作用。这一结果与前人关于碱性磷酸酶诱导剂对化学致癌作用的研究结果一致。所研究物质的致癌作用显然与苯基或磷酸基团或类固醇环的存在无关。肿瘤抑制或促进作用似乎与所试物质诱导或抑制碱性磷酸酶活性的潜力有关。
{"title":"Chemical carcinogenesis in the hamster cheek pouch. Influence of inhibitors and inducers of alkaline phosphatase.","authors":"D Rubin,&nbsp;I S Levij","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Squamous cell carcinomas were induced in the hamster cheek pouch with 9,10-dimethyl-1,2-benzanthracene. The process of carcinogenesis was inhibited by phenylphosphate, an inducer of alkaline phosphatase. Orthophosphate and l-phenylalanine, which inhibit alkaline phosphatase, had a promoting effect on tumor formation. The results are in accordance with those of previous studies on the effect of inducers of alkaline phosphatase on chemical carcinogenesis. The effect of the studied substances on carcinogenesis was apparently unrelated to the presence of phenyl or phosphate groups or of steroid rings. The tumor inhibition or promotion seemed to be related to the potential of the tested substances to induce or inhibit alkaline phosphatase activity.</p>","PeriodicalId":19854,"journal":{"name":"Pathologia et microbiologia","volume":"43 1","pages":"26-30"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12005361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Proceedings: The epidemic of primary pulmonary hypertension in Europe. 欧洲原发性肺动脉高压的流行
Pathologia et microbiologia
Pub Date : 1975-01-01
E Lüthy
{"title":"Proceedings: The epidemic of primary pulmonary hypertension in Europe.","authors":"E Lüthy","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":19854,"journal":{"name":"Pathologia et microbiologia","volume":"43 2-O","pages":"246-7"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12405460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Proceedings: Determination of the combined effects of antibacterial drugs by means of gradient plates]. [论文集:梯度平板法测定抗菌药物联合作用]。
Pathologia et microbiologia
Pub Date : 1975-01-01
J Füllhas
{"title":"[Proceedings: Determination of the combined effects of antibacterial drugs by means of gradient plates].","authors":"J Füllhas","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":19854,"journal":{"name":"Pathologia et microbiologia","volume":"42 4","pages":"222-4"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12405571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Proceedings: Preliminary study of chloramphenicol resistance in Pseudomonas aeruginosa strains]. [论文集:铜绿假单胞菌菌株氯霉素耐药性的初步研究]。
Pathologia et microbiologia
Pub Date : 1975-01-01
S Abdel-Sayed, J C Piffaretti, J S Pitton
{"title":"[Proceedings: Preliminary study of chloramphenicol resistance in Pseudomonas aeruginosa strains].","authors":"S Abdel-Sayed,&nbsp;J C Piffaretti,&nbsp;J S Pitton","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":19854,"journal":{"name":"Pathologia et microbiologia","volume":"42 4","pages":"232-33"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12006663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
类型
全部 化学•材料 生命科学 医学 物理 工程技术 环境•农林 材料科学 地球科学 法学 管理学 化学 环境科学与生态学 计算机科学 教育学 经济学 农林科学 人文科学 生物学 数学 物理与天体物理 心理学 综合性期刊 其他 工业工程 理学 历史学 农学 文学 信息工程
数据库
全部 ACS Publications Elsevier ieeexplore Springer The Royal Society of Chemistry Wiley
期刊
Pathologia et microbiologia
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
﹀
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们：info@booksci.cn
Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1