Eine besondere Form von Leukamie-Erkrankung wird durch eine chromosomale Translokation des MLL-Gens (11q23) charakterisiert. Das normale MLL-Gen kodiert fur ein nukleares Protein, das eine wesentliche Rolle bei Differenzierung und Organbildung spielt. Es vermittelt wichtige epigenetische Eigenschaften, indem es Gewebe-spezifische Promotoren aktiviert und die Transkription dieser aktivierten Gene aufrechterhalt.
{"title":"[Translocations of the MLL gene: New insights into high-risk leukemia].","authors":"Rolf Marschalek","doi":"10.1002/pauz.201200468","DOIUrl":"https://doi.org/10.1002/pauz.201200468","url":null,"abstract":"Eine besondere Form von Leukamie-Erkrankung wird durch eine chromosomale Translokation des MLL-Gens (11q23) charakterisiert. Das normale MLL-Gen kodiert fur ein nukleares Protein, das eine wesentliche Rolle bei Differenzierung und Organbildung spielt. Es vermittelt wichtige epigenetische Eigenschaften, indem es Gewebe-spezifische Promotoren aktiviert und die Transkription dieser aktivierten Gene aufrechterhalt.","PeriodicalId":19878,"journal":{"name":"Pharmazie in Unserer Zeit","volume":"41 3","pages":"196-200"},"PeriodicalIF":0.0,"publicationDate":"2012-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/pauz.201200468","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30798768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Pharmazie in unserer Zeit 3/2012].","authors":"Rolf Marschalek, Theo Dingermann","doi":"10.1002/pauz.201290042","DOIUrl":"https://doi.org/10.1002/pauz.201290042","url":null,"abstract":"","PeriodicalId":19878,"journal":{"name":"Pharmazie in Unserer Zeit","volume":" ","pages":"179"},"PeriodicalIF":0.0,"publicationDate":"2012-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/pauz.201290042","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40195417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Genetic basis of leukemia: Serious consequences of chromosomal translocations].","authors":"Rolf Marschalek","doi":"10.1002/pauz.201200467","DOIUrl":"https://doi.org/10.1002/pauz.201200467","url":null,"abstract":"","PeriodicalId":19878,"journal":{"name":"Pharmazie in Unserer Zeit","volume":"41 3","pages":"190-5"},"PeriodicalIF":0.0,"publicationDate":"2012-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/pauz.201200467","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30798767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gesche Tallen, Günter Henze, Arend von Stackelberg
{"title":"[Treatment of children and adolescents with relapsed ALL: therapy target long-term healing].","authors":"Gesche Tallen, Günter Henze, Arend von Stackelberg","doi":"10.1002/pauz.201200470","DOIUrl":"https://doi.org/10.1002/pauz.201200470","url":null,"abstract":"","PeriodicalId":19878,"journal":{"name":"Pharmazie in Unserer Zeit","volume":"41 3","pages":"214-21"},"PeriodicalIF":0.0,"publicationDate":"2012-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/pauz.201200470","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30798770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Nocebo: Wer's glaubt, wird krank. Von Magnus Heier","authors":"I. Zündorf","doi":"10.1002/PAUZ.201290057","DOIUrl":"https://doi.org/10.1002/PAUZ.201290057","url":null,"abstract":"","PeriodicalId":19878,"journal":{"name":"Pharmazie in Unserer Zeit","volume":"48 1","pages":"259-259"},"PeriodicalIF":0.0,"publicationDate":"2012-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85019639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aufgrund der hohen Heilungsraten nach der Behandlung einer akuten lymphoblastischen Leukamie (ALL) bei Kindern und Jugendlichen wachst die Kohorte der uberlebenden ehemaligen Patienten und viele erreichen das Erwachsenenalter.
{"title":"[Sequelae after successful treatment of ALL in childhood and adolescence: follow-up is precautionary].","authors":"Thorsten Langer","doi":"10.1002/pauz.201200473","DOIUrl":"https://doi.org/10.1002/pauz.201200473","url":null,"abstract":"Aufgrund der hohen Heilungsraten nach der Behandlung einer akuten lymphoblastischen Leukamie (ALL) bei Kindern und Jugendlichen wachst die Kohorte der uberlebenden ehemaligen Patienten und viele erreichen das Erwachsenenalter.","PeriodicalId":19878,"journal":{"name":"Pharmazie in Unserer Zeit","volume":"41 3","pages":"234-8"},"PeriodicalIF":0.0,"publicationDate":"2012-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/pauz.201200473","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30798773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Rezepturen. Probleme erkennen, lösen, vermeiden. Von Gerd Wolf","authors":"Christian Redmann","doi":"10.1002/PAUZ.201290062","DOIUrl":"https://doi.org/10.1002/PAUZ.201290062","url":null,"abstract":"","PeriodicalId":19878,"journal":{"name":"Pharmazie in Unserer Zeit","volume":"169 1","pages":"256-257"},"PeriodicalIF":0.0,"publicationDate":"2012-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86800447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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