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Authors' Response to the Discussion Regarding the Article "Effects of Nature-Based Multisensory Stimulation on Pain Mechanisms in Women with Fibromyalgia Syndrome: A Randomized Double-Blind Placebo-Controlled Trial". 作者对“基于自然的多感觉刺激对纤维肌痛综合征女性疼痛机制的影响:一项随机双盲安慰剂对照试验”一文讨论的回应
IF 1.6 4区 医学 Q2 NURSING Pub Date : 2025-01-15 DOI: 10.1016/j.pmn.2024.12.012
Dogukan Baran Gungormus, José Manuel Pérez-Mármol
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引用次数: 0
Evaluation of Older People's Presentations to the Emergency Department With Pain During and Before the COVID-19 Pandemic. COVID-19大流行期间和之前老年人因疼痛向急诊科就诊的评估
IF 1.6 4区 医学 Q2 NURSING Pub Date : 2025-01-14 DOI: 10.1016/j.pmn.2024.12.007
Zeynep Sofuoğlu, Hale Turhan Damar, Gulsah Sehitoglu Alpagut, Bulent Calik, Eyup Kebapci, Hakan Gulmez, Mustafa Kurtulus, Muhammet Damar

Background: This study aimed to determine the tendency of older adults to present to the emergency department with pain complaints during the COVID-19 pandemic compared to the prepandemic period.

Methods: A cross-sectional, retrospective study design was used. Data were collected from the electronic medical records of older people who presented to emergency departments with pain before (March 2019-March 2020) and during the COVID-19 pandemic (April 2020-July 2021). We identified 10 pain diagnosis groups using ICD-10 codes. Patient data were grouped and cleaned using SQL scripts on the Oracle database.

Results: It was determined that 13.3% of 405,404 older people had presented to the emergency department with pain between March 2019 and July 2021. There was a 14.2% decrease in such admissions during the pandemic period. In the study, an increase was observed in the rates of older adults presenting to the emergency department with myalgia and joint pain. In contrast, the rates of those presenting with low back and neck pain, headache, eye pain, dysuria, and acute pain decreased during the pandemic. In the regression analysis, predictors for older adults' presentation to the emergency department with pain included age over 85 years (OR: 1.403), female gender (OR: 1.053), and myalgia (OR: 2.471).

Conclusions: During the COVID-19 pandemic, our study revealed fewer presentations to the emergency department for pain-related complaints. To prevent severe health problems from delayed care, we recommend expanding telemedicine, remote pain management, and home-based care. Further research is needed to examine the long-term effects of increased myalgia and joint pain.

背景:本研究旨在确定在COVID-19大流行期间,与大流行前相比,老年人因疼痛主诉到急诊室就诊的趋势。方法:采用横断面、回顾性研究设计。数据收集于2019年3月- 2020年3月之前和2020年4月- 2021年7月COVID-19大流行期间因疼痛到急诊室就诊的老年人的电子病历。我们使用ICD-10代码确定了10个疼痛诊断组。在Oracle数据库上使用SQL脚本对患者数据进行分组和清理。结果:确定在2019年3月至2021年7月期间,405404名老年人中有13.3%因疼痛就诊于急诊科。在大流行期间,这类入院人数减少了14.2%。在这项研究中,老年人因肌痛和关节痛到急诊室就诊的比例有所增加。相比之下,在大流行期间,出现腰背和颈部疼痛、头痛、眼痛、排尿困难和急性疼痛的患者比例有所下降。在回归分析中,老年人因疼痛到急诊科就诊的预测因素包括年龄超过85岁(OR: 1.403)、女性(OR: 1.053)和肌痛(OR: 2.471)。结论:在COVID-19大流行期间,我们的研究显示,到急诊室就诊的疼痛相关投诉减少了。为了防止因延误护理而造成严重的健康问题,我们建议扩大远程医疗、远程疼痛管理和家庭护理。需要进一步的研究来检验肌痛和关节疼痛增加的长期影响。
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引用次数: 0
Efficacy of Acupuncture in Postoperative Pain-Relieving: A Systematic Review and Meta-Analysis. 针刺在术后镇痛中的疗效:一项系统综述和meta分析。
IF 1.6 4区 医学 Q2 NURSING Pub Date : 2025-01-14 DOI: 10.1016/j.pmn.2024.12.014
Jin Liu, Yinyin Li, Junya Liu, Xingshuo Zhang

Objectives: This study aimed to assess the efficacy of acupuncture in relieving postoperative pain.

Design: Systematic review and meta-analysis.

Data sources: The search strategy was designed according to the PICOS principle (population, intervention, comparison, outcome, and study). PubMed, Web of Science, Cochrane Library, and Embase were searched from the inception of databases to August 25th, 2022 to collect studies on acupuncture in the management of postoperative pain.

Review methods: Two researchers independently screened the searched studies using the EndNote X9 software. Relevant data were extracted, and the risk of bias in included studies was assessed. RevMan 5.4 software was used for data analysis, and the Grading of Recommendations, Assessment, Development, and Evaluation was used to assess the quality of evidence.

Results: A total of 25 studies were included. This meta-analysis showed statistically significant differences in the pain scores (SMD=-0.38, 95 %CI [-0.69, -0.07], p = .02) and the dosage of analgesics (SMD = -0.53, 95% CI [-0.99, -0.06], I2 = 90 %, p < .00001] between the acupuncture group and the control group.

Conclusion: Acupuncture is effective for alleviating postoperative pain and reducing the dosage of analgesics. More well-designed, and large-scale prospective studies are needed to further validate the efficacy of acupuncture in relieving postoperative pain.

Nursing practice implications: Acupuncture is an acceptable choice for relieving postoperative pain since it is convenient, effective, and acceptable. Nurses can provide tailored guidance for patients to enhance their recovery and satisfaction.

目的:本研究旨在评估针刺对缓解术后疼痛的疗效。设计:系统回顾和荟萃分析。数据来源:根据PICOS原则(人群、干预、比较、结果和研究)设计搜索策略。检索PubMed、Web of Science、Cochrane Library和Embase数据库自建库至2022年8月25日,收集针灸治疗术后疼痛的相关研究。综述方法:两位研究者使用EndNote X9软件对检索到的研究进行独立筛选。提取相关资料,评估纳入研究的偏倚风险。采用RevMan 5.4软件进行数据分析,采用推荐、评估、发展和评价分级法评价证据质量。结果:共纳入25项研究。meta分析显示,针刺组与对照组疼痛评分(SMD=-0.38, 95% CI [-0.69, -0.07], p = 0.02)和镇痛药用量(SMD= -0.53, 95% CI [-0.99, -0.06], I2 = 90%, p < 0.00001)差异均有统计学意义。结论:针刺可有效减轻术后疼痛,减少镇痛药用量。需要更多精心设计的、大规模的前瞻性研究来进一步验证针灸缓解术后疼痛的疗效。护理实践启示:针灸是一种可接受的选择,以减轻术后疼痛,因为它方便,有效,和可接受的。护士可以为患者提供量身定制的指导,以提高患者的康复和满意度。
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引用次数: 0
Effect of Virtual Reality on Pain, Anxiety, and Vital Signs in Endoscopy. 虚拟现实对内镜疼痛、焦虑和生命体征的影响。
IF 1.6 4区 医学 Q2 NURSING Pub Date : 2025-01-13 DOI: 10.1016/j.pmn.2024.11.009
Kübra Aslan, Zülfünaz Özer, Mustafa Kemal Yöntem

Aim: This study was conducted to evaluate the effect of relaxation exercise with VR (Virtual Reality) glasses on pain severity, anxiety level, and vital signs in patients undergoing endoscopy.

Methods: This is a quasi-experimental study including a control group with a pretest/post-test applied. This study was conducted with a total of 100 patients, including 50 patients in the intervention and 50 patients in the control group. The data were collected by using Personal Information Form, Visual Analogue Scale (VAS), Visual Anxiety Scale, Vital Signs Form and Virtual Reality Glass Application Satisfaction Form.

Results: In the inter group evaluation, the mean systolic and diastolic blood pressure, heart rate and respiratory rate of the patients in the experimental group after endoscopy were found to be lower than the control group (p < .05). When the effect size value (Cohen d) of this finding was examined, it was found that the application of virtual reality glasses had a large effect on systolic and diastolic blood pressure and a moderate effect on respiration and heart rate. It was found that the mean VAS score of the patients in the control group after the endoscopy procedure was significantly higher than their mean values before the procedure (p = .001). There was no statistically significant difference in the mean VAS scores, anxiety scores and O2 saturation values of the patients in the experimental and control groups after the endoscopy. The mean virtual reality glasses satisfaction value of the patients was found to be 6.98.

Conclusion: Relaxation exercise performed with virtual reality glasses has positive effects on mean systolic and diastolic blood pressure values, heart rate and respiratory rate in patients undergoing endoscopy. In line with these results, it is recommended that the use of virtual reality glasses during endoscopy should be widespread by nurses.

目的:本研究旨在评估VR(虚拟现实)眼镜放松运动对内镜患者疼痛程度、焦虑水平和生命体征的影响。方法:本研究为准实验研究,包括对照组,采用前测/后测。本研究共纳入100例患者,其中干预组50例,对照组50例。采用《个人信息表》、《视觉模拟量表》、《视觉焦虑量表》、《生命体征表》和《虚拟现实眼镜应用满意度表》进行数据采集。结果:在组间评价中,实验组患者内镜检查后的平均收缩压、舒张压、心率、呼吸频率均低于对照组(p < 0.05)。当检查这一发现的效应大小值(Cohen d)时,发现虚拟现实眼镜的应用对收缩压和舒张压有很大的影响,对呼吸和心率有中等的影响。结果发现,对照组患者术后VAS评分均值显著高于术前VAS评分均值(p = .001)。实验组和对照组患者术后VAS评分、焦虑评分、血氧饱和度均值比较,差异均无统计学意义。患者对虚拟现实眼镜的平均满意值为6.98。结论:使用虚拟现实眼镜进行放松运动对内镜患者的平均收缩压、舒张压值、心率和呼吸频率有积极影响。根据这些结果,建议护士在内窥镜检查中广泛使用虚拟现实眼镜。
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引用次数: 0
Quality of Headache Management in Inpatients. 住院病人头痛治疗的质量。
IF 1.6 4区 医学 Q2 NURSING Pub Date : 2025-01-10 DOI: 10.1016/j.pmn.2024.12.006
Eulalia Gine-Cipres, Marta Torres-Ferrus, Victor J Gallardo, Alicia Alpuente Ruiz, Edoardo Caronna, Patricia Pozo-Rosich

Purpose: Headache is a prevalent and highly disabling neurological disorder. There are no data on its prevalence in and impact on hospitalized patients. The objective of this study was to describe the prevalence of headache in hospitalized patients, triggers associated with headaches in this population, and compliance with documentation in the electronic medical record system (EMRS).

Design: This was a prospective, descriptive, observational, cross-sectional study. Inpatients who agreed were included.

Methods: Demographic data, admission-related data, and headache data were collected. Data were obtained from the EMRS and direct interviews with patients. Data were collected at three time points in 2021 and 2022. Statistical analysis, comprising primary and secondary data analysis, was performed with R.

Results: Of the 403 admitted patients, 65.5% (264 of 403) participated. A total of 39% (103 of 264) had presented with headache during their hospitalization, of whom 48.5% (50 of 103) had experienced headache in the preceding 24 hours. Of these, 35.9% (37 of 103) identified stress and 26.2% (27 of 103) identified noise as the most frequent triggers and 24.3% (25 of 103) identified headache as a secondary symptom derived from the cause of admission. During the daily follow-up by the nurse, 95.5% (252 of 264) of patients indicated that they had been asked about pain in general and 11.4% (30 of 264) indicated that they had been asked specifically about headache. No records were obtained from the computer program because although some patients were asked about headache, answers were not recorded in the prespecified "headache" item in the EMRS.

Conclusions: Headache is a prevalent symptom in hospitalized patients. Health care professionals should ask, register, and care about headache routinely to improve patients' well-being.

目的:头痛是一种普遍且高度致残的神经系统疾病。没有关于其在住院患者中的流行程度和影响的数据。本研究的目的是描述住院患者头痛的患病率,与头痛相关的触发因素,以及电子病历系统(EMRS)文件的依从性。设计:这是一项前瞻性、描述性、观察性、横断面研究。同意的住院患者也包括在内。方法:收集人口学资料、入院相关资料和头痛资料。数据来自EMRS和对患者的直接访谈。数据收集于2021年和2022年的三个时间点。结果:403例住院患者中,65.5%(403例中264例)参与了研究。共有39%(264人中的103人)在住院期间出现头痛,其中48.5%(103人中的50人)在住院前24小时内出现头痛。其中,35.9%(37 / 103)认为压力和26.2%(27 / 103)认为噪音是最常见的诱因,24.3%(25 / 103)认为头痛是入院原因引起的次要症状。在护士的日常随访中,95.5%(264人中的252人)的患者表示他们被问及一般的疼痛,11.4%(264人中的30人)的患者表示他们被问及具体的头痛。没有从计算机程序中获得记录,因为虽然一些患者被问及头痛,但答案没有记录在EMRS中预先指定的“头痛”项目中。结论:头痛是住院患者的常见症状。卫生保健专业人员应该定期询问、登记和关心头痛,以改善患者的健康状况。
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引用次数: 0
Association Between Nurses' Comfort and Confidence in Pain Management and Compassion Satisfaction and Fatigue. 护士疼痛管理的舒适度与信心、同情满意度与疲劳的关系。
IF 1.6 4区 医学 Q2 NURSING Pub Date : 2025-01-08 DOI: 10.1016/j.pmn.2024.12.003
Kristin A Schuller, Ebru Cayir Burke

Purpose: A current challenge that may exacerbate symptoms of compassion fatigue and compromise the ability to experience compassion satisfaction among nurses is pain management. This study examined the associations between nurses' comfort with administering pain management, confidence in providers' prescribing patterns and reported compassion satisfaction and compassion fatigue (measured as burnout and secondary traumatic stress).

Design: This exploratory study used a survey design to gather primary data from nurses via a convenience sampling method.

Methods: A survey was created and disseminated electronically to registered nurses from September to November 2019. The survey asked about nurses' comfort administering pain medications, confidence in providers' prescribing patterns, and the Professional Quality of Life Scale (ProQOL).

Results: While nurses reported comfort treating patients with pain and managing pain, they were less confident that providers opioid prescribing patterns. Confidence in provider prescribing was positively correlated with compassion satisfaction and negatively correlated with burnout.

Conclusions: Organizations should focus on continuing education of pain management, creating a culture of evidence-based pain management, and promoting effective communication.

目的:当前的一个挑战可能会加剧同情疲劳的症状,并损害护士体验同情满意度的能力是疼痛管理。本研究考察了护士对实施疼痛管理的舒适度、对提供者处方模式的信心、报告的同情满意度和同情疲劳(以倦怠和继发性创伤压力衡量)之间的关系。设计:本探索性研究采用调查设计,通过方便的抽样方法收集护士的原始数据。方法:于2019年9月至11月对注册护士进行电子调查。该调查询问了护士在使用止痛药时的舒适度,对提供者处方模式的信心,以及职业生活质量量表(ProQOL)。结果:虽然护士报告了对疼痛患者的舒适治疗和疼痛管理,但他们对提供阿片类药物处方模式的信心不足。医师处方信心与同情满意度正相关,与倦怠负相关。结论:组织应关注疼痛管理的继续教育,创建循证疼痛管理文化,促进有效沟通。
{"title":"Association Between Nurses' Comfort and Confidence in Pain Management and Compassion Satisfaction and Fatigue.","authors":"Kristin A Schuller, Ebru Cayir Burke","doi":"10.1016/j.pmn.2024.12.003","DOIUrl":"https://doi.org/10.1016/j.pmn.2024.12.003","url":null,"abstract":"<p><strong>Purpose: </strong>A current challenge that may exacerbate symptoms of compassion fatigue and compromise the ability to experience compassion satisfaction among nurses is pain management. This study examined the associations between nurses' comfort with administering pain management, confidence in providers' prescribing patterns and reported compassion satisfaction and compassion fatigue (measured as burnout and secondary traumatic stress).</p><p><strong>Design: </strong>This exploratory study used a survey design to gather primary data from nurses via a convenience sampling method.</p><p><strong>Methods: </strong>A survey was created and disseminated electronically to registered nurses from September to November 2019. The survey asked about nurses' comfort administering pain medications, confidence in providers' prescribing patterns, and the Professional Quality of Life Scale (ProQOL).</p><p><strong>Results: </strong>While nurses reported comfort treating patients with pain and managing pain, they were less confident that providers opioid prescribing patterns. Confidence in provider prescribing was positively correlated with compassion satisfaction and negatively correlated with burnout.</p><p><strong>Conclusions: </strong>Organizations should focus on continuing education of pain management, creating a culture of evidence-based pain management, and promoting effective communication.</p>","PeriodicalId":19959,"journal":{"name":"Pain Management Nursing","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142953199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Breast Pain in Randomized Controlled Trials: Options Beyond the Daily Visual Analog Scale. 随机对照试验中的乳房疼痛:每日视觉模拟量表之外的选择。
IF 1.6 4区 医学 Q2 NURSING Pub Date : 2025-01-04 DOI: 10.1016/j.pmn.2024.12.002
Mithilesh Kumar Sinha, Apurba Barman
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引用次数: 0
Conditioned Pain Modulation (CPM) Paradigms: Reliability and Relationship With Individual Characteristics. 条件疼痛调节(CPM)范式:信度与个体特征的关系。
IF 1.6 4区 医学 Q2 NURSING Pub Date : 2024-12-31 DOI: 10.1016/j.pmn.2024.12.001
Antonio Gil-Ugidos, Lara Rubal-Otero, Alberto González-Villar, María Teresa Carrillo-De-la-Peña

Purpose: Conditioned Pain Modulation (CPM) is a useful tool for testing the functionality of endogenous pain modulation. However, inconsistent results have been obtained in clinical populations, possibly due to the wide variety of CPM protocols used and the influence of demographic and psychological characteristics of the individuals assessed.

Methods: We tested the sensitivity and reliability of four commonly used CPM paradigms in a sample of 58 healthy participants. We also checked how these measures were related to Temporal Summation of Second Pain (TSSP), sociodemographic (age and sex) and psychological variables (anxiety and stress).

Results: CPM results were influenced by the test stimulus used, with tests using pain pressure threshold (PPT) obtaining a greater number of responders (over 65%) and being the most sensitive (higher size effect: Cohen's d > 0.5). However, all measures showed excellent intrasession reliability, with strong agreement between the CPM magnitudes. CPM indices were not correlated with TSSP, age or sex, and the psychological scales did not differentiate CPM responders and non-responders.

Conclusions: Although the CPM indices showed good reliability, construction of a large database with standardized values for healthy individuals seems necessary for the use of CPM in clinical settings.

目的:条件疼痛调节(CPM)是测试内源性疼痛调节功能的有用工具。然而,在临床人群中获得了不一致的结果,这可能是由于所使用的CPM方案种类繁多,以及受评估个体的人口统计学和心理特征的影响。方法:在58名健康被试中,对四种常用CPM范式进行敏感性和信度检验。我们还检查了这些措施与第二次疼痛时间总和(TSSP)、社会人口学(年龄和性别)和心理变量(焦虑和压力)的关系。结果:CPM结果受测试刺激的影响,使用疼痛压力阈值(PPT)的测试获得更多的反应(超过65%),并且最敏感(更高大小效应:Cohen's d > 0.5)。然而,所有的测量都显示出良好的行业内可靠性,CPM数值之间具有很强的一致性。CPM指数与TSSP、年龄和性别无关,心理量表对CPM反应者和无反应者没有区分。结论:虽然CPM指标显示出良好的可靠性,但在临床环境中使用CPM似乎有必要建立一个具有健康个体标准化值的大型数据库。
{"title":"Conditioned Pain Modulation (CPM) Paradigms: Reliability and Relationship With Individual Characteristics.","authors":"Antonio Gil-Ugidos, Lara Rubal-Otero, Alberto González-Villar, María Teresa Carrillo-De-la-Peña","doi":"10.1016/j.pmn.2024.12.001","DOIUrl":"https://doi.org/10.1016/j.pmn.2024.12.001","url":null,"abstract":"<p><strong>Purpose: </strong>Conditioned Pain Modulation (CPM) is a useful tool for testing the functionality of endogenous pain modulation. However, inconsistent results have been obtained in clinical populations, possibly due to the wide variety of CPM protocols used and the influence of demographic and psychological characteristics of the individuals assessed.</p><p><strong>Methods: </strong>We tested the sensitivity and reliability of four commonly used CPM paradigms in a sample of 58 healthy participants. We also checked how these measures were related to Temporal Summation of Second Pain (TSSP), sociodemographic (age and sex) and psychological variables (anxiety and stress).</p><p><strong>Results: </strong>CPM results were influenced by the test stimulus used, with tests using pain pressure threshold (PPT) obtaining a greater number of responders (over 65%) and being the most sensitive (higher size effect: Cohen's d > 0.5). However, all measures showed excellent intrasession reliability, with strong agreement between the CPM magnitudes. CPM indices were not correlated with TSSP, age or sex, and the psychological scales did not differentiate CPM responders and non-responders.</p><p><strong>Conclusions: </strong>Although the CPM indices showed good reliability, construction of a large database with standardized values for healthy individuals seems necessary for the use of CPM in clinical settings.</p>","PeriodicalId":19959,"journal":{"name":"Pain Management Nursing","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Incidence and Risk Factors for Moderate to Severe Pain After Foot and Ankle Surgery: A Retrospective Study. 足和踝关节手术后中重度疼痛的发生率和危险因素:一项回顾性研究。
IF 1.6 4区 医学 Q2 NURSING Pub Date : 2024-12-28 DOI: 10.1016/j.pmn.2024.12.004
Busara Sirivanasandha, Pongpeera Jitsrisakda, Dudsadee Atungkoon, Wiruntri Punchuklang, Arissara Iamaroon

Background: Severe pain after foot/ankle surgeries is often underestimated because these procedures are perceived as less extensive than other orthopedic surgeries. However, surgeries involving the bones and joints in the foot and ankle can result in intense pain.

Aims: This study aimed to identify the incidence and risk factors associated with postoperative moderate to severe pain.

Design: We reviewed the medical records of 334 patients undergoing foot/ankle surgery under spinal anesthesia. The maximum numeric rating scale (NRS) pain scores were recorded at 12-hour intervals for 48 hours postsurgery, and the incidence of postoperative pain was calculated. Patients were then classified into two groups based on their maximum NRS score from the first postoperative day: those with no or mild pain (NRS score of 0-3) and those with moderate to severe pain (NRS score of 4-10). We collected variables related to the patient, surgery, and anesthesia and used logistic regression analysis to identify the factors associated with moderate to severe pain.

Results: Approximately 67% of patients experienced moderate to severe pain on the first day after foot/ankle surgery, with the peak severity occurring during the initial 12 hours. Performing spinal anesthesia alone (adjusted risk ratio [ARR], 1.44; 95% confidence interval [CI], 1.21-1.71; p < .001) and hindfoot/ankle surgery (ARR, 1.22; 95% CI, 1.03-1.44; p = .020) were identified as independent risk factors for moderate to severe pain.

Conclusions: Due to the high incidence of severe pain following foot/ankle surgery, patients who had spinal anesthetic alone or underwent hindfoot/ankle surgery are more likely to experience moderate to severe pain. Improved pain management measures are crucial for these patients to achieve better outcomes.

背景:足部/踝关节手术后的剧烈疼痛通常被低估,因为这些手术被认为比其他骨科手术范围小。然而,涉及足部和踝关节的手术会导致剧烈的疼痛。目的:本研究旨在确定与术后中至重度疼痛相关的发生率和危险因素。设计:我们回顾了334例在脊髓麻醉下进行足/踝关节手术的患者的医疗记录。术后48小时每隔12小时记录一次最大数值评定量表(NRS)疼痛评分,并计算术后疼痛发生率。然后根据患者术后第一天的最高NRS评分将患者分为两组:无疼痛或轻度疼痛组(NRS评分0-3)和中度至重度疼痛组(NRS评分4-10)。我们收集了与患者、手术和麻醉相关的变量,并使用逻辑回归分析来确定与中度至重度疼痛相关的因素。结果:大约67%的患者在足/踝关节手术后的第一天出现中度至重度疼痛,严重程度在最初的12小时内达到高峰。单独实施脊髓麻醉(校正风险比[ARR], 1.44;95%置信区间[CI], 1.21-1.71;p < .001)和后足/踝关节手术(ARR, 1.22;95% ci, 1.03-1.44;P = 0.020)被确定为中重度疼痛的独立危险因素。结论:由于足/踝关节手术后严重疼痛的发生率较高,单独行脊髓麻醉或后足/踝关节手术的患者更容易出现中度至重度疼痛。改善疼痛管理措施对这些患者取得更好的结果至关重要。
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引用次数: 0
Association of COMT rs4680 Genotype With Chronic Neuropathic Pain Experience in Patients With Sickle Cell Disease. COMT rs4680基因型与镰状细胞病患者慢性神经性疼痛经历的关系
IF 1.6 4区 医学 Q2 NURSING Pub Date : 2024-12-28 DOI: 10.1016/j.pmn.2024.11.010
Abigail R Islam, Gebre-Egziabher Kiros, Rachael O Ajiboye, Keesha Powell-Roach, Miriam O Ezenwa, R Renee Reams, Robert E Molokie, Zaijie Jim Wang, Yingwei Yao, Diana J Wilkie

Purpose: The pain experience of patients with sickle cell disease (SCD) frequently consists of episodes of acute exacerbation. However, recent studies suggest that many patients who suffer from SCD have symptoms of chronic neuropathic pain. Additional research is needed to determine what role genotype plays in the patient's pain phenotype experience in SCD. The purpose of our project was to determine whether a catechol-O-methyltransferase (COMT) single nucleotide polymorphism (SNP), rs4680, was associated with the experience of chronic neuropathic pain in patients with SCD.

Design: Cross sectional study.

Method: In our study, 184 patients (98% African American, mean age 36.5 ± 11.6 years, 63% female) completed the Self-Reported Leeds Assessment of Neuropathic Symptoms and Signs (S-LANNS) and the Neuropathic Pain Symptom Inventory (NPSI) and provided blood samples for genotyping of the rs4680 SNP. We conducted a cross-sectional association study using a likelihood ratio test that compared a model with and without genotype as a predictor. We also used linear regression model to determine whether the Met allele was associated with pain in an additive model.

Result: 50% of the study participants had a Val/Val genotype, 41% had a Val/Met, and 9% had a MET/MET. Between the three rs4680 genotypes, the differences in the mean S-LANNS or NPSI scores were not statistically significant. The Met allele was also not significantly associated with neuropathic pain (S-LANNS p = .23; NPSI p = .73) in an additive SNP model.

Conclusion: Further studies with larger samples are needed to determine if the Met/Met genotype predisposes patients with SCD to neuropathic pain and if other polymorphisms in the COMT gene play a role in this process.

目的:镰状细胞病(SCD)患者的疼痛经历经常由急性加重发作组成。然而,最近的研究表明,许多患有SCD的患者有慢性神经性疼痛的症状。需要进一步的研究来确定基因型在SCD患者疼痛表型体验中所起的作用。我们项目的目的是确定儿茶酚- o -甲基转移酶(COMT)单核苷酸多态性(SNP) rs4680是否与SCD患者的慢性神经性疼痛经历相关。设计:横断面研究。方法:184例患者(98%为非裔美国人,平均年龄36.5±11.6岁,63%为女性)完成了自我报告利兹神经症状和体征评估(S-LANNS)和神经性疼痛症状量表(NPSI),并提供血样进行rs4680 SNP基因分型。我们使用似然比检验进行了一项横断面关联研究,比较了有和没有基因型作为预测因子的模型。我们还使用线性回归模型在加性模型中确定Met等位基因是否与疼痛相关。结果:50%的研究参与者有Val/Val基因型,41%有Val/Met基因型,9%有Met /Met基因型。3个rs4680基因型间S-LANNS均值和NPSI评分差异均无统计学意义。Met等位基因与神经性疼痛也无显著相关性(S-LANNS p = 0.23;在加性SNP模型中NPSI p = .73)。结论:需要更大样本的进一步研究来确定Met/Met基因型是否使SCD患者易患神经性疼痛,以及COMT基因的其他多态性是否在这一过程中发挥作用。
{"title":"Association of COMT rs4680 Genotype With Chronic Neuropathic Pain Experience in Patients With Sickle Cell Disease.","authors":"Abigail R Islam, Gebre-Egziabher Kiros, Rachael O Ajiboye, Keesha Powell-Roach, Miriam O Ezenwa, R Renee Reams, Robert E Molokie, Zaijie Jim Wang, Yingwei Yao, Diana J Wilkie","doi":"10.1016/j.pmn.2024.11.010","DOIUrl":"10.1016/j.pmn.2024.11.010","url":null,"abstract":"<p><strong>Purpose: </strong>The pain experience of patients with sickle cell disease (SCD) frequently consists of episodes of acute exacerbation. However, recent studies suggest that many patients who suffer from SCD have symptoms of chronic neuropathic pain. Additional research is needed to determine what role genotype plays in the patient's pain phenotype experience in SCD. The purpose of our project was to determine whether a catechol-O-methyltransferase (COMT) single nucleotide polymorphism (SNP), rs4680, was associated with the experience of chronic neuropathic pain in patients with SCD.</p><p><strong>Design: </strong>Cross sectional study.</p><p><strong>Method: </strong>In our study, 184 patients (98% African American, mean age 36.5 ± 11.6 years, 63% female) completed the Self-Reported Leeds Assessment of Neuropathic Symptoms and Signs (S-LANNS) and the Neuropathic Pain Symptom Inventory (NPSI) and provided blood samples for genotyping of the rs4680 SNP. We conducted a cross-sectional association study using a likelihood ratio test that compared a model with and without genotype as a predictor. We also used linear regression model to determine whether the Met allele was associated with pain in an additive model.</p><p><strong>Result: </strong>50% of the study participants had a Val/Val genotype, 41% had a Val/Met, and 9% had a MET/MET. Between the three rs4680 genotypes, the differences in the mean S-LANNS or NPSI scores were not statistically significant. The Met allele was also not significantly associated with neuropathic pain (S-LANNS p = .23; NPSI p = .73) in an additive SNP model.</p><p><strong>Conclusion: </strong>Further studies with larger samples are needed to determine if the Met/Met genotype predisposes patients with SCD to neuropathic pain and if other polymorphisms in the COMT gene play a role in this process.</p>","PeriodicalId":19959,"journal":{"name":"Pain Management Nursing","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Pain Management Nursing
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