Pub Date : 2024-07-16DOI: 10.1007/s11094-024-03158-2
A. H. Al-Humairi
{"title":"Experimental In Vitro and In Vivo Studies of the Antitumor Activity of New Azoloazine Derivatives for the Treatment of Breast Cancer","authors":"A. H. Al-Humairi","doi":"10.1007/s11094-024-03158-2","DOIUrl":"https://doi.org/10.1007/s11094-024-03158-2","url":null,"abstract":"","PeriodicalId":19990,"journal":{"name":"Pharmaceutical Chemistry Journal","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141641431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-16DOI: 10.1007/s11094-024-03176-0
Muhammad Abbas, Muhammad Tayyab Ansari, Musharraf Abbas
{"title":"Improved and Validated Quantitative Spectroscopic Analysis of Chlorpheniramine in Pharmaceutical Formulations","authors":"Muhammad Abbas, Muhammad Tayyab Ansari, Musharraf Abbas","doi":"10.1007/s11094-024-03176-0","DOIUrl":"https://doi.org/10.1007/s11094-024-03176-0","url":null,"abstract":"","PeriodicalId":19990,"journal":{"name":"Pharmaceutical Chemistry Journal","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141642158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-16DOI: 10.1007/s11094-024-03161-7
Mehtap Tugrak Sakarya, H. Gul, Cem Yamali, Yusuf Ozkay, T. Tok
{"title":"In Vitro Enzyme Activity and Molecular Docking Studies of Pyrazoline Derivatives as Monoamine Oxidase Inhibitors","authors":"Mehtap Tugrak Sakarya, H. Gul, Cem Yamali, Yusuf Ozkay, T. Tok","doi":"10.1007/s11094-024-03161-7","DOIUrl":"https://doi.org/10.1007/s11094-024-03161-7","url":null,"abstract":"","PeriodicalId":19990,"journal":{"name":"Pharmaceutical Chemistry Journal","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141641472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-16DOI: 10.1007/s11094-024-03175-1
R. Gandhimathi, Archana Mandava, K. N. Kalyani, P. Indhumathy, V. Kommineni
{"title":"Development and Validation of a Novel HPLC Method for the Simultaneous Determination of Pregabalin and Etoricoxib in Bulk and Pharmaceutical Dosage Form","authors":"R. Gandhimathi, Archana Mandava, K. N. Kalyani, P. Indhumathy, V. Kommineni","doi":"10.1007/s11094-024-03175-1","DOIUrl":"https://doi.org/10.1007/s11094-024-03175-1","url":null,"abstract":"","PeriodicalId":19990,"journal":{"name":"Pharmaceutical Chemistry Journal","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141642338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-16DOI: 10.1007/s11094-024-03162-6
S. Sukanya, T. Venkatesh, K. Upendranath, H. Shanavaz, O. Nagaraj
{"title":"Synthesis, In-Vitro Evaluation and Docking Studies of Novel 6-Amino-4-Substituted-Pyrano[3,2-d]Isoxazole-5-Carbonitrile Derivatives as Potential Anti-Diabetic and Anticancer Agents","authors":"S. Sukanya, T. Venkatesh, K. Upendranath, H. Shanavaz, O. Nagaraj","doi":"10.1007/s11094-024-03162-6","DOIUrl":"https://doi.org/10.1007/s11094-024-03162-6","url":null,"abstract":"","PeriodicalId":19990,"journal":{"name":"Pharmaceutical Chemistry Journal","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141641026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-16DOI: 10.1007/s11094-024-03172-4
A. S. Minero, O. B. Runova, M. G. Korotkov, O. Ustinnikova
{"title":"Development of a Method for Quantitative Determination of Carbohydrate Stabilizers in Biologics Based on HPLC with Refractometric Detection","authors":"A. S. Minero, O. B. Runova, M. G. Korotkov, O. Ustinnikova","doi":"10.1007/s11094-024-03172-4","DOIUrl":"https://doi.org/10.1007/s11094-024-03172-4","url":null,"abstract":"","PeriodicalId":19990,"journal":{"name":"Pharmaceutical Chemistry Journal","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141641926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-15DOI: 10.1007/s11094-024-03168-0
Mostafa Akbari, M. Taherkhani
{"title":"Phytochemical Analysis of Extract and Essential Oil of Echinophora platyloba","authors":"Mostafa Akbari, M. Taherkhani","doi":"10.1007/s11094-024-03168-0","DOIUrl":"https://doi.org/10.1007/s11094-024-03168-0","url":null,"abstract":"","PeriodicalId":19990,"journal":{"name":"Pharmaceutical Chemistry Journal","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141645369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-15DOI: 10.1007/s11094-024-03164-4
Chandrakant G. Bonde, Ritesh P. Bhole, Ashish Asrodkar, Rupesh V Chikhale, Shailendra S. Gurav
A simple and promising methodology was employed for the synthesis of (Z)-1-(benzo[d]thiazol-2-yl)-2-(3-substituted thiazolidine-4-one) hydrazine as antitubercular agents. In vitro activity was tested against Mycobacterium tuberculosis. Two derivatives among all the synthesized compounds were found to be highly effective. Furthermore, to rationalize the observed biological activity data, a molecular docking study has also been carried out against a potential target DprE1 enzyme. The interaction was shown between the oxygen of thiazolidinediones and Ser228. The bond distance (O—H) is 2.35 Å. The π-π-stacking was seen between His137 and thiazole ring electrons. The binding score of compound 15 is –7 kcal/mol, which suggests an excellent binding affinity toward the Dpre1 receptor.
{"title":"Design, Synthesis and Biological Evaluation of (Z)-1-(Benzo[D]Thiazol-2-yl)-2-(3-Substituted Thiazolidine-4-One) Hydrazine Dpre1 Inhibitors as Antimycobacterial Agents","authors":"Chandrakant G. Bonde, Ritesh P. Bhole, Ashish Asrodkar, Rupesh V Chikhale, Shailendra S. Gurav","doi":"10.1007/s11094-024-03164-4","DOIUrl":"https://doi.org/10.1007/s11094-024-03164-4","url":null,"abstract":"<p>A simple and promising methodology was employed for the synthesis of <i>(Z</i>)-1-(benzo[<i>d</i>]thiazol-2-yl)-2-(3-substituted thiazolidine-4-one) hydrazine as antitubercular agents<i>.</i> In vitro activity was tested against <i>Mycobacterium tuberculosis</i>. Two derivatives among all the synthesized compounds were found to be highly effective. Furthermore, to rationalize the observed biological activity data, a molecular docking study has also been carried out against a potential target DprE1 enzyme. The interaction was shown between the oxygen of thiazolidinediones and Ser228. The bond distance (O—H) is 2.35 Å. The π-π-stacking was seen between His137 and thiazole ring electrons. The binding score of compound 15 is –7 kcal/mol, which suggests an excellent binding affinity toward the Dpre1 receptor.</p>","PeriodicalId":19990,"journal":{"name":"Pharmaceutical Chemistry Journal","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141718417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-15DOI: 10.1007/s11094-024-03159-1
V. S. Rogovskii, A. D. Kukushkina, N. L. Shimanovskii
{"title":"Influence of Urolithin A and Cholecalciferol on IFN-γ Production by Peripheral Blood Mononuclear Cells Under Normal Conditions and in the Presence of Products Released by Tumor Cells","authors":"V. S. Rogovskii, A. D. Kukushkina, N. L. Shimanovskii","doi":"10.1007/s11094-024-03159-1","DOIUrl":"https://doi.org/10.1007/s11094-024-03159-1","url":null,"abstract":"","PeriodicalId":19990,"journal":{"name":"Pharmaceutical Chemistry Journal","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141647787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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