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Effects of transcutaneous electrical nerve stimulation on acute postoperative breast augmentation pain: study protocol. 经皮神经电刺激对隆胸术后急性疼痛的影响:研究方案。
IF 1.4 Q4 CLINICAL NEUROLOGY Pub Date : 2024-12-01 Epub Date: 2024-11-26 DOI: 10.1080/17581869.2024.2434450
Kamylla Caroline Santos, Mariana Arias Avila, Gilberto Inacio Cardoso Neto, Alexandre Fabricio Martucci, Natiele Camponogara Righi, Richard Eloin Liebano

The aim of this study is to describe a protocol for evaluating the effects of transcutaneous electrical nerve stimulation (TENS) on pain following breast augmentation surgery. Fifty-four women will be randomly allocated into two groups: active TENS and placebo. Pain will be assessed at rest and during movement, before and immediately after TENS application. Secondary outcomes include pain one-hour post-treatment, respiratory muscle strength, patient satisfaction, and analgesic use in the first four hours post-surgery. The results of this clinical trial could enhance the management of post-operative pain in breast augmentation surgery using non-pharmacological interventions, potentially reducing costs and improving patient experience.Clinical Trial Registration: RBR-96h3k97.

本研究旨在描述经皮神经电刺激(TENS)对隆胸手术后疼痛影响的评估方案。54 名女性将被随机分为两组:活性 TENS 组和安慰剂组。将在使用 TENS 之前和之后立即对休息时和运动时的疼痛进行评估。次要结果包括治疗后一小时的疼痛、呼吸肌力量、患者满意度以及术后前四小时的镇痛剂使用情况。这项临床试验的结果可加强对隆胸手术术后疼痛的管理,采用非药物干预措施,有可能降低成本并改善患者体验:临床试验注册:RBR-96h3k97。
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引用次数: 0
A team approach to adhesive capsulitis with ultrasound guided hydrodilatation: a retrospective study.
IF 1.4 Q4 CLINICAL NEUROLOGY Pub Date : 2024-12-01 Epub Date: 2024-11-29 DOI: 10.1080/17581869.2024.2435803
Michael Dakkak, Jason Genin, Lauren Wichman, Chao Zhang, Vikas Patel

Background: Adhesive capsulitis (AC) causes shoulder pain and limited range of motion. While ultrasound-guided suprascapular nerve block, glenohumeral joint hydrodilatation, and physical therapy are effective individually, their combined use is not well-studied.

Objective: This study evaluates the effect and safety of combining ultrasound-guided suprascapular nerve block, glenohumeral joint hydrodilatation, and physical therapy on range of motion and pain, comparing diabetic and non-diabetic patients.

Design: Retrospective Cohort; Level of Evidence 3.

Methods: 150 patients (30-75 years) with AC received ultrasound-guided suprascapular nerve block, glenohumeral joint hydrodilatation with corticosteroid injection, and subsequent physical therapy. Baseline Visual Analog Scale (VAS) pain score, active forward flexion, and external rotation range of motion were measured using a goniometer. At 3 months post-procedure, range of motion and pain were reevaluated.

Results: Significant improvements in active forward flexion (median improvement of 25 degrees) and external rotation (median improvement of 19 degrees) were observed at 3 months (p < 0.001). No complications were reported.

Conclusion: Combining ultrasound-guided suprascapular nerve block, glenohumeral joint hydrodilatation, and physical therapy is safe, effective, and improves pain, flexion, and external rotation range of motion in patients with adhesive capsulitis.

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引用次数: 0
Ultrasound-guided regional anesthesia (UGRA) in the emergency department: a scoping review. 急诊科超声引导区域麻醉 (UGRA):范围综述。
IF 1.4 Q4 CLINICAL NEUROLOGY Pub Date : 2024-10-01 Epub Date: 2024-11-24 DOI: 10.1080/17581869.2024.2431474
Syed Mohammad J Mahmood, Nikhil B Bhana, Clarence Kong, Nik Theyyunni, William J Schaeffer, Charles W Kropf, Nicole T Klekowski, Brendan W Munzer, Zachary B Rotter, Ashley E Hall, Jonathan D Porath, William J Peterson, Ryan V Tucker

Introduction: While many studies have been published on Ultrasound-guided regional anesthesia in the Emergency Department (ED), there has been no previous study assessing the current state of the literature based in the form of a scoping review.

Objective: The purpose of this study is to evaluate the current state of the literature on UGRA performed in the ED setting.

Methods: EMBASE, MEDLINE, CINAHL, and Cochrane databases were searched for studies. Following PRISMA-ScR guidelines (Figure 1), two reviewers evaluated each title and abstract and were included if they described a UGRA technique performed on patients in the ED by an ED provider. Cohen's kappa coefficients were calculated for each level of review.[Figure: see text].

Results: Of the 1,456 abstracts, a total of 53 articles were included in the analysis, of which 28 (52.8%) were case series and 11 (20.8%) were randomized control trials (RCTs). The most common types of nerve block represented in these studies were femoral nerve/fascia iliaca (14), brachial plexus (7), and forearm (radial, ulnar, median nerves) (7). 47 of the 53 articles were published in or after the year 2010.

Conclusion: Current literature supporting UGRA use in the ED is growing but unbalanced, requiring large population studies to demonstrate safety and efficacy of these techniques.

简介:虽然已经发表了许多关于急诊科(ED)超声引导区域麻醉的研究,但此前还没有以范围综述的形式对文献现状进行评估的研究:本研究旨在评估在急诊科环境下进行 UGRA 的文献现状:方法:检索 EMBASE、MEDLINE、CINAHL 和 Cochrane 数据库中的相关研究。按照 PRISMA-ScR 指南(图 1),两名审稿人对每篇标题和摘要进行评估,如果其中描述了急诊室医疗人员在急诊室对患者实施的 UGRA 技术,则将其纳入。每级评审均计算了科恩卡帕系数(Cohen's kappa coefficient):在 1,456 篇摘要中,共有 53 篇文章被纳入分析,其中 28 篇(52.8%)为病例系列,11 篇(20.8%)为随机对照试验(RCT)。这些研究中最常见的神经阻滞类型包括股神经/髂筋膜(14)、臂丛神经(7)和前臂神经(桡神经、尺神经和正中神经)(7)。53 篇文章中有 47 篇发表于 2010 年或之后:目前支持在急诊室使用 UGRA 的文献越来越多,但并不平衡,需要进行大规模的人群研究来证明这些技术的安全性和有效性。
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引用次数: 0
The use of music in the treatment of chronic pain: a scoping review.
IF 1.4 Q4 CLINICAL NEUROLOGY Pub Date : 2024-10-01 Epub Date: 2024-11-29 DOI: 10.1080/17581869.2024.2435243
Elise Cournoyer Lemaire, Michel Perreault

Objective: Music is a promising strategy to address the physical, psychological, and social needs of people with chronic pain. To better understand its potential in the treatment of chronic pain, this study aims to assess the state of knowledge regarding the effects of music in the context of chronic pain treatment.

Methods: A scoping review was conducted in eight databases using music, chronic pain, and treatment concepts and associated keywords. Studies were included in the review if they reported some effects of any form of music on chronic pain or concomitant conditions.

Results: Sixty-three studies were identified. Results showed numerous benefits of music-based interventions on chronic pain and common concomitant difficulties including emotional regulation, anxiety and depression symptoms, and social issues. Though literature supports varied forms of music-based interventions, those that account for participants' preferences and that encourage self-management and autonomy appeared to be the most effective.

Conclusions: Despite the benefits of music in the management of pain and concomitant difficulties, there remain few examples of applied music interventions in services designed for people who experience chronic pain. More research is needed to identify the musical modalities that would be the most adapted and effective to complement chronic pain services.

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引用次数: 0
Patient and staff perspectives on pain treatment experiences in a community clinic serving under-resourced older adults. 在一家为资源匮乏的老年人服务的社区诊所中,病人和员工对疼痛治疗经验的看法。
IF 1.4 Q4 CLINICAL NEUROLOGY Pub Date : 2024-10-01 Epub Date: 2024-11-27 DOI: 10.1080/17581869.2024.2432852
Julie R Brewer, Katherine A McDermott, Jonathan Greenberg, Alexander M Presciutti, Danielle E LaCamera, Christine S Ritchie, Ana-Maria Vranceanu

Aims: Chronic pain affects up to 37.8% of older adults with higher prevalence among those in under-resourced communities. While there are many treatments for chronic pain, there are complexities to treating under-resourced older adults in community clinics, including multimorbidity, barriers to treatment access, and varying degrees of openness to different treatment approaches. Understanding patient and clinic staff perceptions of treatment options for chronic pain is critical for implementing treatment approaches that will work sustainably in the community. This study aimed to understand clinic staff and patients' perspectives on chronic pain treatment experiences.

Methods: Focus groups and individual interviews were analyzed using a hybrid inductive-deductive approach.

Results: Themes are: (1) Limited patient and clinic resources and availability affecting pain treatment experiences (e.g., copays, transportation challenges, and conflicting responsibilities), (2) Discrepancies in patient and staff approaches to treatment and the importance of trialing different pain management techniques to alleviate pain (e.g., trialing multiple treatments with varied success), and (3) Conflict between patients' desire for pain elimination vs. staffs' focus on symptom reduction and function (e.g., patient-staff disconnect).

Conclusions: These findings are important for determining how treatments can best fit the needs of under-resourced older adults with chronic pain.

目的:多达 37.8% 的老年人受到慢性疼痛的影响,在资源不足的社区中,慢性疼痛的发病率更高。虽然有许多治疗慢性疼痛的方法,但在社区诊所治疗资源匮乏的老年人却面临着复杂的问题,包括多病共存、获得治疗的障碍以及对不同治疗方法的不同开放程度。了解患者和诊所工作人员对慢性疼痛治疗方案的看法对于实施可在社区持续发挥作用的治疗方法至关重要。本研究旨在了解诊所工作人员和患者对慢性疼痛治疗经验的看法:方法:采用归纳-演绎混合方法对焦点小组和个人访谈进行分析:结果:主题是(1) 有限的患者和诊所资源及可用性影响了疼痛治疗体验(例如,共付额、交通挑战和责任冲突),(2) 患者和工作人员在治疗方法上的差异以及尝试不同疼痛管理技术以减轻疼痛的重要性(例如,尝试多种治疗方法但效果不一),(3) 患者对消除疼痛的渴望与工作人员对减轻症状和功能的关注之间的冲突(例如,患者与工作人员脱节):这些发现对于确定如何治疗才能最符合资源不足的慢性疼痛老年人的需求非常重要。
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引用次数: 0
Spinal cord stimulation in a patient with an implantable cardioverter defibrillator for managing chronic chest pain: a case report and literature review. 植入式心脏除颤器患者脊髓刺激治疗慢性胸痛:病例报告和文献综述。
IF 1.4 Q4 CLINICAL NEUROLOGY Pub Date : 2024-10-01 Epub Date: 2024-11-14 DOI: 10.1080/17581869.2024.2426971
Porras Bueno Cristian Orlando, Rangel Jaimes German William, Camargo Cárdenas Anamaria, Cediel Carrillo Ximena, Berdugo Pereira Eliana Milena

The simultaneous use of spinal cord stimulation (SCS) and an implantable cardioverter-defibrillator (ICD) is safe and effective in selected patients with refractory chest pain. Our case highlights successful pain management with SCS without compromising ICD function. Careful patient selection, low device settings, and ongoing monitoring are crucial for achieving optimal outcomes.

对于选定的难治性胸痛患者,同时使用脊髓刺激(SCS)和植入式心律转复除颤器(ICD)是安全有效的。我们的病例强调了在不影响 ICD 功能的情况下使用 SCS 成功控制疼痛的效果。谨慎选择患者、降低设备设置和持续监测是获得最佳疗效的关键。
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引用次数: 0
Antidepressants for pain in adults. 治疗成人疼痛的抗抑郁药。
IF 1.4 Q4 CLINICAL NEUROLOGY Pub Date : 2024-10-01 Epub Date: 2024-11-24 DOI: 10.1080/17581869.2024.2432281
Giovanni E Ferreira, Hanan McLachlan, Andrew J McLachlan
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引用次数: 0
The efficacy of topical 8% capsaicin patches for the treatment of postsurgical neuropathic pain: a systematic review. 8%辣椒素外用贴片治疗手术后神经病理性疼痛的疗效:系统性综述。
IF 1.4 Q4 CLINICAL NEUROLOGY Pub Date : 2024-10-01 Epub Date: 2024-11-26 DOI: 10.1080/17581869.2024.2433931
Brandon Goodwin, Jessica Mitchell, Erin Major, Alicia Podwojniak, Hanna Brancaccio, Katarina Rusinak, Matthew King, Hassan Tahir

Objective: To investigate the benefits of topical 8% capsaicin patches for the decrease of postsurgical neuropathic pain level and area.

Methods: A systematic review with pooled analysis was conducted utilizing the PRISMA 2020 guidelines. Five commonly used databases were employed utilizing a search string made from MeSH terms and boolean operators. Retrieved articles were then subjected to title and abstract appraisal, followed by full-text appraisal by two independent reviewers and an adjudicator to break ties.

Results: A total of 127 articles were retrieved from five commonly used databases. Of the 127 articles, 20 were subjected to full-text appraisal, with 12 remaining for inclusion. Due to a heterogeneity greater than the 50% threshold provided by Cochrane, a random-effects pooled-analysis was conducted in lieu of meta-analysis. The random-effects pooled-analysis denotes an overall Cohen's d of 1.09 (95% CI: 0.58-1.56; p < 0.001). All studies that investigated neuropathic pain area denote a decrease in pain size, with some denoting a continued reduction with subsequent application.

Conclusion: Further larger randomized-controlled trials are required to strengthen the position of topical capsaicin patches in the physician's armamentarium.

Protocol registration: www.crd.york.ac.uk/prospero identifier is CRD42024542508.

目的研究 8%辣椒素外用贴片对降低手术后神经病理性疼痛程度和面积的益处:采用 PRISMA 2020 指南进行了一项系统性综述和汇总分析。利用由 MeSH 术语和布尔运算符组成的检索字符串,对五个常用数据库进行了检索。对检索到的文章进行标题和摘要评审,然后由两名独立评审员和一名裁定员对全文进行评审,以打破平局:结果:从五个常用数据库中共检索到 127 篇文章。在这 127 篇文章中,20 篇进行了全文鉴定,剩下 12 篇可供纳入。由于异质性大于 Cochrane 规定的 50%阈值,因此进行了随机效应汇总分析以代替荟萃分析。随机效应汇总分析结果表明,总的 Cohen's d 为 1.09(95% CI:0.58-1.56;P 结论:随机效应汇总分析结果表明,该疗法的异质性大于 Cochrane 规定的 50%阈值:需要进一步开展更大规模的随机对照试验,以加强外用辣椒素贴片在医生用药中的地位。协议注册:www.crd.york.ac.uk/prospero 识别码为 CRD42024542508。
{"title":"The efficacy of topical 8% capsaicin patches for the treatment of postsurgical neuropathic pain: a systematic review.","authors":"Brandon Goodwin, Jessica Mitchell, Erin Major, Alicia Podwojniak, Hanna Brancaccio, Katarina Rusinak, Matthew King, Hassan Tahir","doi":"10.1080/17581869.2024.2433931","DOIUrl":"10.1080/17581869.2024.2433931","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the benefits of topical 8% capsaicin patches for the decrease of postsurgical neuropathic pain level and area.</p><p><strong>Methods: </strong>A systematic review with pooled analysis was conducted utilizing the PRISMA 2020 guidelines. Five commonly used databases were employed utilizing a search string made from MeSH terms and boolean operators. Retrieved articles were then subjected to title and abstract appraisal, followed by full-text appraisal by two independent reviewers and an adjudicator to break ties.</p><p><strong>Results: </strong>A total of 127 articles were retrieved from five commonly used databases. Of the 127 articles, 20 were subjected to full-text appraisal, with 12 remaining for inclusion. Due to a heterogeneity greater than the 50% threshold provided by Cochrane, a random-effects pooled-analysis was conducted in lieu of meta-analysis. The random-effects pooled-analysis denotes an overall Cohen's d of 1.09 (95% CI: 0.58-1.56; <i>p</i> < 0.001). All studies that investigated neuropathic pain area denote a decrease in pain size, with some denoting a continued reduction with subsequent application.</p><p><strong>Conclusion: </strong>Further larger randomized-controlled trials are required to strengthen the position of topical capsaicin patches in the physician's armamentarium.</p><p><strong>Protocol registration: </strong>www.crd.york.ac.uk/prospero identifier is CRD42024542508.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"591-598"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11622774/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142716817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A novel approach to refractory coccydynia: ultrasound- fluoroscopy-guided cryoablation of sacrococcygeal nerve. 治疗难治性尾骨痛的新方法:超声-透视引导下的骶尾部神经冷冻消融术。
IF 1.4 Q4 CLINICAL NEUROLOGY Pub Date : 2024-10-01 Epub Date: 2024-11-17 DOI: 10.1080/17581869.2024.2430162
Inês Mendes-Andrade, Robert Pagan-Rosado, Nuno Ferreira-Silva, Mark Friedrich Hurdle

Coccydynia, also termed chronic pain in the tailbone, is a complex condition with limited treatment options for refractory cases. This case series introduces a novel approach for treating refractory coccydynia using cryoablation of the sacrococcygeal nerves under combined ultrasound and fluoroscopy guidance. Two female patients, suffering from chronic pain for over six months and unresponsive to conservative interventions, underwent cryoablation. Both patients reported significant pain relief, with more than 50% reduction in their numeric rating scale scores, and no major complications were observed during or after the procedure. Furthermore, we propose a clinical treatment algorithm to assist in selecting appropriate interventions for refractory coccydynia, based on the anatomical source of the pain. The findings suggest that cryoablation may be a valuable option for patients with persistent coccygeal pain; however, larger prospective studies are required to confirm its efficacy and long-term safety.

尾骨痛又称慢性尾骨痛,是一种复杂的疾病,难治性病例的治疗方案有限。本病例系列介绍了一种治疗难治性尾骨痛的新方法,即在超声波和透视联合引导下对骶尾部神经进行冷冻消融。两名女性患者被慢性疼痛折磨了六个多月,对保守治疗无效,她们接受了冷冻消融术。两名患者的疼痛都得到了明显缓解,数字评分量表评分降低了 50%以上,术中和术后均未发现重大并发症。此外,我们还提出了一种临床治疗算法,以协助根据疼痛的解剖学来源选择适当的干预措施来治疗难治性尾骨痛。研究结果表明,低温消融术可能是顽固性尾骨痛患者的一种有价值的选择;但还需要更大规模的前瞻性研究来证实其疗效和长期安全性。
{"title":"A novel approach to refractory coccydynia: ultrasound- fluoroscopy-guided cryoablation of sacrococcygeal nerve.","authors":"Inês Mendes-Andrade, Robert Pagan-Rosado, Nuno Ferreira-Silva, Mark Friedrich Hurdle","doi":"10.1080/17581869.2024.2430162","DOIUrl":"10.1080/17581869.2024.2430162","url":null,"abstract":"<p><p>Coccydynia, also termed chronic pain in the tailbone, is a complex condition with limited treatment options for refractory cases. This case series introduces a novel approach for treating refractory coccydynia using cryoablation of the sacrococcygeal nerves under combined ultrasound and fluoroscopy guidance. Two female patients, suffering from chronic pain for over six months and unresponsive to conservative interventions, underwent cryoablation. Both patients reported significant pain relief, with more than 50% reduction in their numeric rating scale scores, and no major complications were observed during or after the procedure. Furthermore, we propose a clinical treatment algorithm to assist in selecting appropriate interventions for refractory coccydynia, based on the anatomical source of the pain. The findings suggest that cryoablation may be a valuable option for patients with persistent coccygeal pain; however, larger prospective studies are required to confirm its efficacy and long-term safety.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"541-547"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11622740/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of transdermal anti-inflammatory patches for musculoskeletal pain: a systematic review and meta-analysis. 透皮消炎贴对肌肉骨骼疼痛的疗效:系统综述和荟萃分析。
IF 1.4 Q4 CLINICAL NEUROLOGY Pub Date : 2024-10-01 Epub Date: 2024-11-22 DOI: 10.1080/17581869.2024.2421153
María B Sánchez, Michael J Callaghan, James Selfe, Michael Twigg, Toby Smith

Aim: To determine the efficacy of transdermal anti-inflammatory patches in the treatment of acute and chronic musculoskeletal pain.Methods: A comprehensive search of: Cochrane Central register of controlled trials, EMBASE, MEDLINE, CINAHL and PubMed, for studies using transdermal anti-inflammatory patches vs placebo for management of musculoskeletal pain, e.g. soft tissue injuries or tendonitis (last search January 2024). Cochrane Risk of Bias Tools v1 was used for quality assessment and GRADE determined certainty of evidence. Meta-analysis was performed.Results: Twenty-three randomized placebo-controlled trials (n = 4729) were included. There was low-certainty evidence that transdermal patches provided statistically and clinically significant pain relief on movement at long-term follow-up for chronic musculoskeletal pain (effect size -2-69 (95% CI: -4.14, -1.24) and at short-term follow-up which was non-clinically significant, (-1.24: 95% CI: -1.78, -0.69).Conclusion: Several types of transdermal anti-inflammatory patches may offer short-term and long-term pain relief for acute and chronic musculoskeletal conditions. However, the clinical significance of this effect for the long-term pain relief was based on low-certainty evidence of transdermal anti-inflammatory patches versus placebo; for short-term pain there was an overall non-clinically significant improvement. Performing a meta-analysis for all outcomes was not possible due to insufficiency in the evidence-base.Protocol registration: www.crd.york.ac.uk/prospero identifier is CRD42020185944.

目的:确定透皮消炎贴对治疗急性和慢性肌肉骨骼疼痛的疗效:方法:全面检索:方法:全面检索:Cochrane 对照试验中央登记簿、EMBASE、MEDLINE、CINAHL 和 PubMed,检索使用透皮消炎贴剂与安慰剂治疗肌肉骨骼疼痛(如软组织损伤或肌腱炎)的研究(最后检索日期为 2024 年 1 月)。质量评估采用 Cochrane Risk of Bias Tools v1,证据确定度采用 GRADE。进行了 Meta 分析:共纳入 23 项随机安慰剂对照试验(n = 4729)。有低确定性证据表明,透皮贴剂在长期随访中对慢性肌肉骨骼疼痛的运动疼痛缓解具有统计学和临床意义(效应大小为-2-69(95% CI:-4.14,-1.24),在短期随访中无临床意义,(-1.24:95% CI:-1.78,-0.69):结论:多种类型的透皮消炎贴片可缓解急性和慢性肌肉骨骼疾病的短期和长期疼痛。然而,对长期疼痛缓解效果的临床意义是基于透皮消炎贴片与安慰剂对比的低确定性证据;对短期疼痛的改善总体上无临床意义。由于证据基础不足,无法对所有结果进行荟萃分析。协议注册:www.crd.york.ac.uk/prospero 识别码为 CRD42020185944。
{"title":"Efficacy of transdermal anti-inflammatory patches for musculoskeletal pain: a systematic review and meta-analysis.","authors":"María B Sánchez, Michael J Callaghan, James Selfe, Michael Twigg, Toby Smith","doi":"10.1080/17581869.2024.2421153","DOIUrl":"10.1080/17581869.2024.2421153","url":null,"abstract":"<p><p><b>Aim:</b> To determine the efficacy of transdermal anti-inflammatory patches in the treatment of acute and chronic musculoskeletal pain.<b>Methods:</b> A comprehensive search of: Cochrane Central register of controlled trials, EMBASE, MEDLINE, CINAHL and PubMed, for studies using transdermal anti-inflammatory patches vs placebo for management of musculoskeletal pain, e.g. soft tissue injuries or tendonitis (last search January 2024). Cochrane Risk of Bias Tools v1 was used for quality assessment and GRADE determined certainty of evidence. Meta-analysis was performed.<b>Results:</b> Twenty-three randomized placebo-controlled trials (n = 4729) were included. There was low-certainty evidence that transdermal patches provided statistically and clinically significant pain relief on movement at long-term follow-up for chronic musculoskeletal pain (effect size -2-69 (95% CI: -4.14, -1.24) and at short-term follow-up which was non-clinically significant, (-1.24: 95% CI: -1.78, -0.69).<b>Conclusion:</b> Several types of transdermal anti-inflammatory patches may offer short-term and long-term pain relief for acute and chronic musculoskeletal conditions. However, the clinical significance of this effect for the long-term pain relief was based on low-certainty evidence of transdermal anti-inflammatory patches versus placebo; for short-term pain there was an overall non-clinically significant improvement. Performing a meta-analysis for all outcomes was not possible due to insufficiency in the evidence-base.<b>Protocol registration:</b> www.crd.york.ac.uk/prospero identifier is CRD42020185944.</p>","PeriodicalId":20000,"journal":{"name":"Pain management","volume":" ","pages":"557-569"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142688410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Pain management
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