: To facilitate the efficient use of phosphate-based glasses in various biomedical applications, it is essential to understand the effects of ion-releasing in the living body. In this work, the ion-releasing behavior of silicophosphate glass, designed as a supply source of silicate and phosphate ions that are effective for bone formation, was investigated. Two types of P 2 O 5 -SiO 2 -CaO-Na 2 O glasses containing 45–50 mol% of P 2 O 5 with both four- and six-fold coordinated silicon structures were prepared. The glass with ~50 mol% of P 2 O 5 content had a higher proportion of six-fold coordinated silicon structure, and it showed a lower ionic release to a simulated body fluid than that with ~45 mol% P 2 O 5 content. The release of the therapeutic ions from the silicophosphate glass can be effectively controlled by choosing their composition.
为了促进磷酸盐基玻璃在各种生物医学应用中的有效使用，有必要了解离子释放在活体中的影响。在这项工作中，研究了硅磷玻璃的离子释放行为，硅磷玻璃被设计为有效的骨形成的硅酸盐和磷酸盐离子的供应来源。制备了两种p2o5 - sio2 - cao - na 2o玻璃，p2o5的质量分数为45-50摩尔%，具有四层和六层硅配位结构。p2o含量为~50 mol%的玻璃具有更高比例的六重配硅结构，其对模拟体液的离子释放量低于p2o含量为~45 mol%的玻璃。通过选择治疗离子的组成，可以有效地控制治疗离子从硅磷酸盐玻璃中的释放。
{"title":"ION RELEASE BEHAVIOR OF SILICOPHOSPHATE GLASSES CONTAINING SIX-FOLD COORDINATED SILICON STRUCTURE","authors":"Atsuhiro Miura, A. Obata, T. Kasuga","doi":"10.3363/prb.38.1","DOIUrl":"https://doi.org/10.3363/prb.38.1","url":null,"abstract":": To facilitate the efficient use of phosphate-based glasses in various biomedical applications, it is essential to understand the effects of ion-releasing in the living body. In this work, the ion-releasing behavior of silicophosphate glass, designed as a supply source of silicate and phosphate ions that are effective for bone formation, was investigated. Two types of P 2 O 5 -SiO 2 -CaO-Na 2 O glasses containing 45–50 mol% of P 2 O 5 with both four- and six-fold coordinated silicon structures were prepared. The glass with ~50 mol% of P 2 O 5 content had a higher proportion of six-fold coordinated silicon structure, and it showed a lower ionic release to a simulated body fluid than that with ~45 mol% P 2 O 5 content. The release of the therapeutic ions from the silicophosphate glass can be effectively controlled by choosing their composition.","PeriodicalId":20022,"journal":{"name":"Phosphorus Research Bulletin","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73210940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"REVISITING WET-CHEMICALLY SYNTHESIZED β-TRICALCIUM PHOSPHATE: SOLID-STATE NMR STUDY OF LOCAL STRUCTURE","authors":"Toshiisa Konishi","doi":"10.3363/prb.38.5","DOIUrl":"https://doi.org/10.3363/prb.38.5","url":null,"abstract":"","PeriodicalId":20022,"journal":{"name":"Phosphorus Research Bulletin","volume":"433 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90944272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective of the present study was to synthesize Mg-free whitlockite (WH) particles using organophosphates with different alkyl chain lengths via a solvothermal reaction. The effects of the organophosphates and their Ca/P molar ratio on the formation of WH were investigated. With increasing alkyl chain length of the organophosphate and increasing Ca/P molar ratio, the dominant phase changed from WH to hydroxyapatite (HA). This result suggests that the organophosphates exhibited different hydrolysis rates. With all of the organophosphates, WHs were obtained only at a Ca/P molar ratio of 0.25. In addition, an analysis of the local structure using H and P nuclear magnetic resonance spectroscopy indicated that the WH contained protonated phosphate (HPO4 ) and trace amount of HA subphase. (Received Jul 12, 2021; Accepted Sept 15, 2021)
{"title":"EFFECT OF ORGANOPHOSPHATES ON THE FORMATION OF MAGNESIUM-FREE WHITLOCKITE","authors":"Toshiisa Konishi, Sadayuki Watanabe","doi":"10.3363/prb.37.26","DOIUrl":"https://doi.org/10.3363/prb.37.26","url":null,"abstract":"Objective of the present study was to synthesize Mg-free whitlockite (WH) particles using organophosphates with different alkyl chain lengths via a solvothermal reaction. The effects of the organophosphates and their Ca/P molar ratio on the formation of WH were investigated. With increasing alkyl chain length of the organophosphate and increasing Ca/P molar ratio, the dominant phase changed from WH to hydroxyapatite (HA). This result suggests that the organophosphates exhibited different hydrolysis rates. With all of the organophosphates, WHs were obtained only at a Ca/P molar ratio of 0.25. In addition, an analysis of the local structure using H and P nuclear magnetic resonance spectroscopy indicated that the WH contained protonated phosphate (HPO4 ) and trace amount of HA subphase. (Received Jul 12, 2021; Accepted Sept 15, 2021)","PeriodicalId":20022,"journal":{"name":"Phosphorus Research Bulletin","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84775955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kakeru Tsuchiya, Shohei Nakata, M. Ohno, Shigetaka Tamagawa, H. Shibata, K. Hashimoto
: The present work is based on prior research into the synthesis of porous β-tricalcium phosphate (β-TCP) with continuous pores by applying a β-TCP suspension onto a porous polyurethane foam by spray coating followed by pyrolysis of the foam. In the work reported herein, the three-dimensional (3D) pore structure of a polyurethane foam specimen was scanned using X-ray computerized tomography after which a porous acrylic foam with an optimized pore structure was fabricated using a 3D printer based on this scan. The pore size and pillar diameter of the porous printed material could be modified simply by changing the brightness value of the image data in the processing software. Specifically, the pillar diameter was increased while the pore size became smaller as the brightness was increased. β-TCP with interconnecting pores could be easily fabricated by spray coating these printed molds. The physical properties and porous structure of the product could also be tuned by modifying the pore structure of the foam and the amount of spray coating. The porous β-TCP obtained in this study had sufficient physical properties to be used as a scaffold material, suggesting the possibility of applying this scanning process to other porous materials, including living bones.
{"title":"FABRICATION OF POROUS β-TRICALCIUM PHOSPHATE SCAFFOLDS USING FOAM REPLICA WITH 3D TECHNOLOGY","authors":"Kakeru Tsuchiya, Shohei Nakata, M. Ohno, Shigetaka Tamagawa, H. Shibata, K. Hashimoto","doi":"10.3363/prb.37.32","DOIUrl":"https://doi.org/10.3363/prb.37.32","url":null,"abstract":": The present work is based on prior research into the synthesis of porous β-tricalcium phosphate (β-TCP) with continuous pores by applying a β-TCP suspension onto a porous polyurethane foam by spray coating followed by pyrolysis of the foam. In the work reported herein, the three-dimensional (3D) pore structure of a polyurethane foam specimen was scanned using X-ray computerized tomography after which a porous acrylic foam with an optimized pore structure was fabricated using a 3D printer based on this scan. The pore size and pillar diameter of the porous printed material could be modified simply by changing the brightness value of the image data in the processing software. Specifically, the pillar diameter was increased while the pore size became smaller as the brightness was increased. β-TCP with interconnecting pores could be easily fabricated by spray coating these printed molds. The physical properties and porous structure of the product could also be tuned by modifying the pore structure of the foam and the amount of spray coating. The porous β-TCP obtained in this study had sufficient physical properties to be used as a scaffold material, suggesting the possibility of applying this scanning process to other porous materials, including living bones.","PeriodicalId":20022,"journal":{"name":"Phosphorus Research Bulletin","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86123324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Calcium phosphates (CPs) were widely used as synthetic bone graft substitutes. However, the control of particle size and morphology of CP materials have not been achieved substantially, even though these factors would influence the physicochemical properties. Recent studies revealed that a uniform nanostructured Mg-free whitlockite (WH), which was structurally similar to a high temperature polymorph of β-tricalcium phosphate, was synthesized by precipitation in organic solvents of N,N-dimethylformamide (DMF) and ethylene glycol (EG). The present study therefore aims to synthesize WH particles in the DMF-EG binary solvents by a solvothermal reaction to investigate the formation mechanism of the WH particles. The nucleation of the amorphous precursor, which occurred at 3 h, was dominated by the slow hydrolysis of organophosphate, which retarded reaching critical supersaturation and hindered the fast nucleation. The investigation on the effect of reaction time on WH formation revealed that the amorphous-precursor mediated WH formation via a solid-solid phase transformation occurred between 4 and 9 h of reaction time. (Received Mar 19, 2021; Accepted Apr 13, 2021)
{"title":"AMORPHOUS-PRECURSOR MEDIATED FORMATION OF MAGNESIUM-FREE WHITLOCKITE","authors":"Toshiisa Konishi, Sadayuki Watanabe","doi":"10.3363/PRB.37.1","DOIUrl":"https://doi.org/10.3363/PRB.37.1","url":null,"abstract":"Calcium phosphates (CPs) were widely used as synthetic bone graft substitutes. However, the control of particle size and morphology of CP materials have not been achieved substantially, even though these factors would influence the physicochemical properties. Recent studies revealed that a uniform nanostructured Mg-free whitlockite (WH), which was structurally similar to a high temperature polymorph of β-tricalcium phosphate, was synthesized by precipitation in organic solvents of N,N-dimethylformamide (DMF) and ethylene glycol (EG). The present study therefore aims to synthesize WH particles in the DMF-EG binary solvents by a solvothermal reaction to investigate the formation mechanism of the WH particles. The nucleation of the amorphous precursor, which occurred at 3 h, was dominated by the slow hydrolysis of organophosphate, which retarded reaching critical supersaturation and hindered the fast nucleation. The investigation on the effect of reaction time on WH formation revealed that the amorphous-precursor mediated WH formation via a solid-solid phase transformation occurred between 4 and 9 h of reaction time. (Received Mar 19, 2021; Accepted Apr 13, 2021)","PeriodicalId":20022,"journal":{"name":"Phosphorus Research Bulletin","volume":"213 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85876111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
We here report a single-step, rapid synthesis method for magnesium whitlockite (MgWH). The hydrothermal synthesis of MgWH by transformation of calcium hydrogen phosphate dihydrate (DCPD) in formic acid solution was investigated. The fraction of MgWH increased with increasing Mg ion concentration. Single-phase MgWH with monodisperse, hexahedral-shaped particles was obtained when the reaction was conducted in the presence of 15 mmol/L Mg ions and at 220 °C for more than 3 h. The results also indicated that the hydrothermal transformation into MgWH in the presence of Mg ions was not pH-dependent precipitation but thermodynamically stable precipitation. Local structure analysis by H and P nuclear magnetic resonance confirmed the presence of protonated phosphate (HPO4 ) and showed three distinct phosphate peaks corresponding to the MgWH structure, which were consistent with the crystal structure of conventional MgWH. (Received Jul 12, 2021; Accepted Sept 15, 2021)
{"title":"HYDROTHERMAL TRANSFORMATION OF CALCIUM HYDROGEN PHOSPHATE DIHYDRATE INTO MAGNESIUM WHITLOCKITE","authors":"Toshiisa Konishi, Sadayuki Watanabe","doi":"10.3363/prb.37.21","DOIUrl":"https://doi.org/10.3363/prb.37.21","url":null,"abstract":"We here report a single-step, rapid synthesis method for magnesium whitlockite (MgWH). The hydrothermal synthesis of MgWH by transformation of calcium hydrogen phosphate dihydrate (DCPD) in formic acid solution was investigated. The fraction of MgWH increased with increasing Mg ion concentration. Single-phase MgWH with monodisperse, hexahedral-shaped particles was obtained when the reaction was conducted in the presence of 15 mmol/L Mg ions and at 220 °C for more than 3 h. The results also indicated that the hydrothermal transformation into MgWH in the presence of Mg ions was not pH-dependent precipitation but thermodynamically stable precipitation. Local structure analysis by H and P nuclear magnetic resonance confirmed the presence of protonated phosphate (HPO4 ) and showed three distinct phosphate peaks corresponding to the MgWH structure, which were consistent with the crystal structure of conventional MgWH. (Received Jul 12, 2021; Accepted Sept 15, 2021)","PeriodicalId":20022,"journal":{"name":"Phosphorus Research Bulletin","volume":"63 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79169535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
: Calcium phosphate-based ceramics, in particular, biodegradable β- and α-tricalcium phosphate (TCP), have re-ceived much attention as synthetic bone substitutes. Although there is a consensus that β- and α-TCP are both high temperature polymorphs, in which the β phase transforms to the α phase at above ~1125 °C, recent extensive studies reported novel synthetic methods for TCP and related materials such as magnesium- or magnesium-free whitlockite at temperatures below 800 °C. While several synthesis methods for TCP and related materials have been reported, few have focused on the low-temperature synthesis of TCP and related materials, but rather on conventional methods. Therefore, the focus of this short review is upon the low-temperature synthesis of TCP and related materials. In addition, future strategies to synthesize three-dimensional shapes of TCP and related materials at low temperature are discussed.
{"title":"LOW-TEMPERATURE SYNTHESIS OF TRICALCIUM PHOSPHATE AND RELATED MATERIALS","authors":"Toshiisa Konishi","doi":"10.3363/PRB.37.11","DOIUrl":"https://doi.org/10.3363/PRB.37.11","url":null,"abstract":": Calcium phosphate-based ceramics, in particular, biodegradable β- and α-tricalcium phosphate (TCP), have re-ceived much attention as synthetic bone substitutes. Although there is a consensus that β- and α-TCP are both high temperature polymorphs, in which the β phase transforms to the α phase at above ~1125 °C, recent extensive studies reported novel synthetic methods for TCP and related materials such as magnesium- or magnesium-free whitlockite at temperatures below 800 °C. While several synthesis methods for TCP and related materials have been reported, few have focused on the low-temperature synthesis of TCP and related materials, but rather on conventional methods. Therefore, the focus of this short review is upon the low-temperature synthesis of TCP and related materials. In addition, future strategies to synthesize three-dimensional shapes of TCP and related materials at low temperature are discussed.","PeriodicalId":20022,"journal":{"name":"Phosphorus Research Bulletin","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87882969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hideko Maeda, Tadashi Matsushima, Takeshi Nagai, H. Nakayama
Phosphonylations of 5’-deoxy-5-fluorouridine (5’-DFUR) and 1--D-arabinofuranosylcytosine (Ara C) in aqueous solution were successfully performed using disodium diphosphonate (DP, Na2P2O5H2). The former reaction resulted in the synthesis of both 3’-phosphonyl-5’-DFUR and 2’-phosphonyl-5’-DFUR, with an overall yield of 100%. The reaction of 1--D-arabinofuranosylcytosine (Ara C) with DP gave 5’-phosphonyl-Ara C, 3’-phosphonyl-Ara C and 2’-phosphonyl-Ara C in a total yield of more than 35%. The optimal condition for the phosphonylation of either 5’-DFUR or Ara C with DP was determined to be a 1:10 ratio of 5’-DFUR or Ara C to DP and a solution pH of 11. The phosphonylated products of 5’-DFUR and Ara C were stable at 10 oC and 25 oC, respectively, over the pH range of 7 to 9. A proposed mechanism for the reactions of 5’-DFUR and Ara C with DP was developed. (Received Nov 10, 2020; Accepted Nov 30, 2020)
{"title":"PHOSPHONYLATION OF 5’-DEOXY-5-FLUOROURIDINE AND 1-?-D-ARABINOFURANOSYLCYTOSINE WITH DISODIUM DIPHOSPHONATE","authors":"Hideko Maeda, Tadashi Matsushima, Takeshi Nagai, H. Nakayama","doi":"10.3363/prb.36.29","DOIUrl":"https://doi.org/10.3363/prb.36.29","url":null,"abstract":"Phosphonylations of 5’-deoxy-5-fluorouridine (5’-DFUR) and 1--D-arabinofuranosylcytosine (Ara C) in aqueous solution were successfully performed using disodium diphosphonate (DP, Na2P2O5H2). The former reaction resulted in the synthesis of both 3’-phosphonyl-5’-DFUR and 2’-phosphonyl-5’-DFUR, with an overall yield of 100%. The reaction of 1--D-arabinofuranosylcytosine (Ara C) with DP gave 5’-phosphonyl-Ara C, 3’-phosphonyl-Ara C and 2’-phosphonyl-Ara C in a total yield of more than 35%. The optimal condition for the phosphonylation of either 5’-DFUR or Ara C with DP was determined to be a 1:10 ratio of 5’-DFUR or Ara C to DP and a solution pH of 11. The phosphonylated products of 5’-DFUR and Ara C were stable at 10 oC and 25 oC, respectively, over the pH range of 7 to 9. A proposed mechanism for the reactions of 5’-DFUR and Ara C with DP was developed. (Received Nov 10, 2020; Accepted Nov 30, 2020)","PeriodicalId":20022,"journal":{"name":"Phosphorus Research Bulletin","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85994184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hasnat Zamin, Takeshi Yabutsuka, S. Takai, H. Sakaguchi
A comparative study of polyvinylidene fluoride (PVDF) and polycaprolactone (PCL) incorporated with particles of amorphous calcium phosphate on the induction of apatite formation ability in simulated body fluid (SBF)-biomimetic environment has been investigated. PVDF and PCL films containing amorphous calcium phosphate particles were fabricated using the solvent casting method. These amorphous calcium phosphate particles were highly active in inducing apatite formation. Results showed that both PCL and PVDF successfully resulted in apatite formation in SBF. However, it was found that the amount of amorphous calcium phosphate particles and the induction period of the apatite formation in SBF significantly varied for PVDF and PCL. These types of bioactive polymeric composite materials are attractive candidates as bone restorative materials with flexibility as well as high apatite forming ability. (Received Aug 28, 2020; Accepted Sep 11, 2020)
{"title":"A COMPARITIVE IN VITRO BIOACTIVY EVALUATION OF POLYVINYLIDENE FLUORIDE AND POLYCAPROLACTONE INCORPORATED WITH AMORPHOUS CALCIUM PHOSPHATE PARTICLES","authors":"Hasnat Zamin, Takeshi Yabutsuka, S. Takai, H. Sakaguchi","doi":"10.3363/prb.36.15","DOIUrl":"https://doi.org/10.3363/prb.36.15","url":null,"abstract":"A comparative study of polyvinylidene fluoride (PVDF) and polycaprolactone (PCL) incorporated with particles of amorphous calcium phosphate on the induction of apatite formation ability in simulated body fluid (SBF)-biomimetic environment has been investigated. PVDF and PCL films containing amorphous calcium phosphate particles were fabricated using the solvent casting method. These amorphous calcium phosphate particles were highly active in inducing apatite formation. Results showed that both PCL and PVDF successfully resulted in apatite formation in SBF. However, it was found that the amount of amorphous calcium phosphate particles and the induction period of the apatite formation in SBF significantly varied for PVDF and PCL. These types of bioactive polymeric composite materials are attractive candidates as bone restorative materials with flexibility as well as high apatite forming ability. (Received Aug 28, 2020; Accepted Sep 11, 2020)","PeriodicalId":20022,"journal":{"name":"Phosphorus Research Bulletin","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81333851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Magnesium is an essential element to the human body, and Mg ion can work to enhance cell adhesion, proliferation, differentiation, and mineralization. From the viewpoint of inorganic glass formation, MgO can be classified as an intermediate, that improves the glass-forming and ion-releasing abilities. The present work reports fundamental data for designing MgO-containing bioactive phosphate glasses with manipulated ion-releasability. MgO-CaO-P2O5-TiO2 invert glasses were prepared, in which TiO2 was substituted by MgO, and their structure and dissolution behavior were examined. Magnesium in the glasses was preferentially bonded to orthophosphate groups. The glass-forming ability and chemical durability of the glasses decreased with increasing MgO content, since P-O-Mg bonds are weaker than P-O-Ti bonds. In contrast, the ion-releasing ability of the glasses improved with increasing MgO content, and the released amount of Mg ion was expected to be within the range suitable to stimulate cell adhesion and proliferation. (Received Jul 10, 2020; Accepted Aug 13, 2020)
镁是人体必需的元素，镁离子可以增强细胞的粘附、增殖、分化和矿化。从无机玻璃形成的角度来看，MgO可归类为中间体，提高了玻璃形成和离子释放能力。本工作报告了设计具有可控离子释放性的含氧化镁生物活性磷酸盐玻璃的基础数据。用MgO取代TiO2制备了MgO- cao - p2o5 -TiO2反晶玻璃，并对其结构和溶解行为进行了研究。玻璃中的镁优先与正磷酸盐基团结合。随着MgO含量的增加，玻璃的形成能力和化学耐久性下降，因为P-O-Mg键比P-O-Ti键弱。相反，玻璃的离子释放能力随着MgO含量的增加而提高，Mg离子的释放量有望在适宜刺激细胞粘附和增殖的范围内。(2020年7月10日收稿;接受2020年8月13日)
{"title":"DISSOLUTION BEHAVIOR OF MgO-CaO-P2O5-TiO2 INVERT GLASSES","authors":"Sungho Lee, F. Nagata, Katsuya Kato, T. Kasuga","doi":"10.3363/prb.36.10","DOIUrl":"https://doi.org/10.3363/prb.36.10","url":null,"abstract":"Magnesium is an essential element to the human body, and Mg ion can work to enhance cell adhesion, proliferation, differentiation, and mineralization. From the viewpoint of inorganic glass formation, MgO can be classified as an intermediate, that improves the glass-forming and ion-releasing abilities. The present work reports fundamental data for designing MgO-containing bioactive phosphate glasses with manipulated ion-releasability. MgO-CaO-P2O5-TiO2 invert glasses were prepared, in which TiO2 was substituted by MgO, and their structure and dissolution behavior were examined. Magnesium in the glasses was preferentially bonded to orthophosphate groups. The glass-forming ability and chemical durability of the glasses decreased with increasing MgO content, since P-O-Mg bonds are weaker than P-O-Ti bonds. In contrast, the ion-releasing ability of the glasses improved with increasing MgO content, and the released amount of Mg ion was expected to be within the range suitable to stimulate cell adhesion and proliferation. (Received Jul 10, 2020; Accepted Aug 13, 2020)","PeriodicalId":20022,"journal":{"name":"Phosphorus Research Bulletin","volume":"60 1","pages":"10-14"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88573254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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