Ryuto Kuniya, T. Sumi, S. Horikoshi, T. Toyama, K. Itatani
Preparation conditions of fibrous hydroxyapatite (Ca10(PO4)6(OH)2: HAp) particles were examined by two-step chemical routes: (i) the preparation of fibrous octacalcium phosphate (Ca8H2(PO4)6·5H2O: OCP) particles by homogeneous precipitation, using 0.0333 ~ 0.0500 mol∙dm Ca(NO3)2, 0.0200 ~ 0.0300 mol∙dm 3 (NH4)2HPO4, 0.04 ~ 0.40 mol∙dm 3 urea ((NH2)2CO; precipitant) and conc. HNO3, and (ii) the microwave-assisted hydrothermal heating of OCP particles at 130oC for 1 ~ 3 h. The fibrous HAp particles with the mean long-axis length of 307 m were obtained when the calcium phosphate solution containing 0.0333 mol∙dm Ca(NO3)2, 0.0200 mol∙dm 3 (NH4)2HPO4 and 0.12 mol∙dm 3 (NH2)2CO, was heated under flux at 80oC for 24 h, followed by the microwave-assisted hydrothermal heating at 130oC for 3 h. The mean long-axis length decreased down to 255 m, after the heating under reflux and microwave-assisted hydrothermal heating of the calcium phosphate solution containing 0.050 mol∙dm Ca(NO3)2, 0.030 mol∙dm 3 (NH4)2HPO4 and 0.20 mol∙dm 3 (NH2)2CO. Instead, the microwave-assisted hydrothermal heating of OCP particles in the HAp-dissolved solution, i.e., the dissolution of HAp powder by bubbling CO2 gas, helped increasing the mean long-axis length to 437 m. (Received Dec 7, 2017; Accepted Jan 16, 2018)
{"title":"Preparation of fibrous hydroxyapatite particles by homogeneous precipitation and microwave-assisted hydrothermal heating","authors":"Ryuto Kuniya, T. Sumi, S. Horikoshi, T. Toyama, K. Itatani","doi":"10.3363/PRB.34.1","DOIUrl":"https://doi.org/10.3363/PRB.34.1","url":null,"abstract":"Preparation conditions of fibrous hydroxyapatite (Ca10(PO4)6(OH)2: HAp) particles were examined by two-step chemical routes: (i) the preparation of fibrous octacalcium phosphate (Ca8H2(PO4)6·5H2O: OCP) particles by homogeneous precipitation, using 0.0333 ~ 0.0500 mol∙dm Ca(NO3)2, 0.0200 ~ 0.0300 mol∙dm 3 (NH4)2HPO4, 0.04 ~ 0.40 mol∙dm 3 urea ((NH2)2CO; precipitant) and conc. HNO3, and (ii) the microwave-assisted hydrothermal heating of OCP particles at 130oC for 1 ~ 3 h. The fibrous HAp particles with the mean long-axis length of 307 m were obtained when the calcium phosphate solution containing 0.0333 mol∙dm Ca(NO3)2, 0.0200 mol∙dm 3 (NH4)2HPO4 and 0.12 mol∙dm 3 (NH2)2CO, was heated under flux at 80oC for 24 h, followed by the microwave-assisted hydrothermal heating at 130oC for 3 h. The mean long-axis length decreased down to 255 m, after the heating under reflux and microwave-assisted hydrothermal heating of the calcium phosphate solution containing 0.050 mol∙dm Ca(NO3)2, 0.030 mol∙dm 3 (NH4)2HPO4 and 0.20 mol∙dm 3 (NH2)2CO. Instead, the microwave-assisted hydrothermal heating of OCP particles in the HAp-dissolved solution, i.e., the dissolution of HAp powder by bubbling CO2 gas, helped increasing the mean long-axis length to 437 m. (Received Dec 7, 2017; Accepted Jan 16, 2018)","PeriodicalId":20022,"journal":{"name":"Phosphorus Research Bulletin","volume":"30 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82643557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Catalytically active cerium dioxide is used as light reflection materials for cosmetic applications. Therefore, cosmetics containing this pigment cause oxidation of the skin. From this fact, the substitute for cerium dioxide is required to prepare the cosmetics without catalytic activity. Herein, as novel white pigments for use in cosmetics, cerium phosphate was prepared at various pH values. The chemical composition, powder properties, catalytic activity, color, and smoothness of the cerium phosphate were evaluated. All samples prepared in this work indicated XRD pattern of the cerium phosphate hydrate. The sample prepared at pH 4 had relatively small particles and low static friction resistance. The samples prepared at pH 5, 6, and 7 had no photocatalytic activity. The samples prepared at pH 5 and 6 exhibited high reflectance within the range of visible light. (Received Nov 20, 2018; Accepted Dec 17, 2018)
{"title":"PREPARATION OF NOVEL CERIUM PHOSPHATE WHITE PIGMENT","authors":"H. Onoda, H. Muraki","doi":"10.3363/PRB.34.14","DOIUrl":"https://doi.org/10.3363/PRB.34.14","url":null,"abstract":"Catalytically active cerium dioxide is used as light reflection materials for cosmetic applications. Therefore, cosmetics containing this pigment cause oxidation of the skin. From this fact, the substitute for cerium dioxide is required to prepare the cosmetics without catalytic activity. Herein, as novel white pigments for use in cosmetics, cerium phosphate was prepared at various pH values. The chemical composition, powder properties, catalytic activity, color, and smoothness of the cerium phosphate were evaluated. All samples prepared in this work indicated XRD pattern of the cerium phosphate hydrate. The sample prepared at pH 4 had relatively small particles and low static friction resistance. The samples prepared at pH 5, 6, and 7 had no photocatalytic activity. The samples prepared at pH 5 and 6 exhibited high reflectance within the range of visible light. (Received Nov 20, 2018; Accepted Dec 17, 2018)","PeriodicalId":20022,"journal":{"name":"Phosphorus Research Bulletin","volume":"1 1","pages":"14-18"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88079343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hideko Maeda, Saki Tsuchida, H. Nariai, H. Nakayama
Phosphorylation of hydroxyproline (Hyp) has been achieved using inorganic trisodium- cyclo -triphosphate (P 3m ) in aqueous solution. In the reaction of Hyp (1.5 M) and P 3m (0.5 M), at pH 11, and 10 ºC, N -triphosphoryl hydroxyproline (P 3 -( N )-Hyp) was synthesized. An intramolecular attack of carboxyl group on a phosphorus atom of P 3 -( N )-Hyp yields cyclic phosphate derivative (P 1 -( N , O )-Hyp). Hydrolysis of cyclic phosphate derivative occurs simultaneously to form N -phosphoryl hydroxyproline (P 1 -( N )-Hyp). Here, we were able to show that Hyp reacts with P 3m to form the intermediates (P 3 -( N )-Hyp and (P 1 -( N , O )-Hyp) and give the final product (P 1 -( N )-Hyp). The optimum condition for P 1 -( N )-Hyp was Hyp : P 3m = 2(1.0 M) : 1(0.5 M), pH 13, and 25 ºC. P 1 -( N )-Hyp was synthesized by dissolving Hyp and P 3m in H 2 O under the optimum conditions for 7 days, and isolated by adding 2-propanol to the reaction solution. The moisture retention of P 1 -( N )-Hyp and Hyp alone were compared by measuring amount of water. The moisture retention of the P 1 -( N )-Hyp can be increased more effectively than that of Hyp alone.
{"title":"PHOSPHORYLATION OF HYDROXYPROLINE WITH TRISODIUM CYCLO-TRIPHOSPHATE AND EVALUATION OF THEIR MOISTURE RETAINING PROPERTY","authors":"Hideko Maeda, Saki Tsuchida, H. Nariai, H. Nakayama","doi":"10.3363/PRB.34.9","DOIUrl":"https://doi.org/10.3363/PRB.34.9","url":null,"abstract":"Phosphorylation of hydroxyproline (Hyp) has been achieved using inorganic trisodium- cyclo -triphosphate (P 3m ) in aqueous solution. In the reaction of Hyp (1.5 M) and P 3m (0.5 M), at pH 11, and 10 ºC, N -triphosphoryl hydroxyproline (P 3 -( N )-Hyp) was synthesized. An intramolecular attack of carboxyl group on a phosphorus atom of P 3 -( N )-Hyp yields cyclic phosphate derivative (P 1 -( N , O )-Hyp). Hydrolysis of cyclic phosphate derivative occurs simultaneously to form N -phosphoryl hydroxyproline (P 1 -( N )-Hyp). Here, we were able to show that Hyp reacts with P 3m to form the intermediates (P 3 -( N )-Hyp and (P 1 -( N , O )-Hyp) and give the final product (P 1 -( N )-Hyp). The optimum condition for P 1 -( N )-Hyp was Hyp : P 3m = 2(1.0 M) : 1(0.5 M), pH 13, and 25 ºC. P 1 -( N )-Hyp was synthesized by dissolving Hyp and P 3m in H 2 O under the optimum conditions for 7 days, and isolated by adding 2-propanol to the reaction solution. The moisture retention of P 1 -( N )-Hyp and Hyp alone were compared by measuring amount of water. The moisture retention of the P 1 -( N )-Hyp can be increased more effectively than that of Hyp alone.","PeriodicalId":20022,"journal":{"name":"Phosphorus Research Bulletin","volume":"40 1","pages":"9-13"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76742896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Biological apatite presented in bone and teeth of mammals contains various ions, such as Na, K, Mg, F and CO3 ions, in trace levels. Substitution of the above ions into hydroxyapatite (HAp) have great effect on the crystallinity, morphology, lattice parameters and stability of the apatite structure. It is known that potassium (K) in the living bone give a tremendous effect to the biomineralization process. Aim of this study is to clarify the influence of substitution of potassium into the HAp structure on the properties of powders and ceramics. In this study, we have fabricated the potassium-substituted hydroxyapatite (KAp) ceramics via an ultrasonic spray-pyrolysis route. Effect of potassium substitution on the phase, chemical composition, morphology and crystal lattice structure of HA was examined. Experimental results showed that the addition of potassium does not significantly affect the crystal phase, particle morphology and particle size. Sintered bodies fabricated from KAp powders were of single phase of HAp, and lattice constants of a-axis and c-axis increased with potassium contents. Substitution of potassium into the HAp lattice formed OH vacancies and caused grain growth. (Received Oct 19, 2017; Accepted Nov 21, 2017)
{"title":"FABRICATION OF POTASSIUM-SUBSTITUTED HYDROXYAPATITE CERAMICS VIA ULTRASONIC SPRAY-PYROLYSIS ROUTE","authors":"Tomohiro Yokota, M. Honda, M. Aizawa","doi":"10.3363/PRB.33.35","DOIUrl":"https://doi.org/10.3363/PRB.33.35","url":null,"abstract":"Biological apatite presented in bone and teeth of mammals contains various ions, such as Na, K, Mg, F and CO3 ions, in trace levels. Substitution of the above ions into hydroxyapatite (HAp) have great effect on the crystallinity, morphology, lattice parameters and stability of the apatite structure. It is known that potassium (K) in the living bone give a tremendous effect to the biomineralization process. Aim of this study is to clarify the influence of substitution of potassium into the HAp structure on the properties of powders and ceramics. In this study, we have fabricated the potassium-substituted hydroxyapatite (KAp) ceramics via an ultrasonic spray-pyrolysis route. Effect of potassium substitution on the phase, chemical composition, morphology and crystal lattice structure of HA was examined. Experimental results showed that the addition of potassium does not significantly affect the crystal phase, particle morphology and particle size. Sintered bodies fabricated from KAp powders were of single phase of HAp, and lattice constants of a-axis and c-axis increased with potassium contents. Substitution of potassium into the HAp lattice formed OH vacancies and caused grain growth. (Received Oct 19, 2017; Accepted Nov 21, 2017)","PeriodicalId":20022,"journal":{"name":"Phosphorus Research Bulletin","volume":"82 1","pages":"35-40"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83774976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hideko Maeda, M. Katsushiro, H. Nariai, H. Nakayama
Phosphorylation of -arbutin has been achieved using inorganic cyclo-triphosphate (P3m) in aqueous solution. The optimum condition for the phosphorylation of -arbutin with P3m is -arbutin : P3m = 0.1 mol/L : 0.5 mol/L, pH 11 and 40oC. 4-Triphospho--arbutin was synthesized with the yield of 90%. The reaction mechanism of -arbutin with P3m was discussed. We have successfully introduced the triphosphate group in one molecule. Phosphorylated -arbutin is expected that the permeability of -arbutin into the skin will be increased by introducing a phosphate group. (Received Jul 7, 2017; Accepted Aug 2, 2017)
{"title":"INTRODUCTION OF PHOSPHATE GROUP INTO β-ARBUTIN BY CYCLO-TRIPHOSPHATE","authors":"Hideko Maeda, M. Katsushiro, H. Nariai, H. Nakayama","doi":"10.3363/PRB.33.21","DOIUrl":"https://doi.org/10.3363/PRB.33.21","url":null,"abstract":"Phosphorylation of -arbutin has been achieved using inorganic cyclo-triphosphate (P3m) in aqueous solution. The optimum condition for the phosphorylation of -arbutin with P3m is -arbutin : P3m = 0.1 mol/L : 0.5 mol/L, pH 11 and 40oC. 4-Triphospho--arbutin was synthesized with the yield of 90%. The reaction mechanism of -arbutin with P3m was discussed. We have successfully introduced the triphosphate group in one molecule. Phosphorylated -arbutin is expected that the permeability of -arbutin into the skin will be increased by introducing a phosphate group. (Received Jul 7, 2017; Accepted Aug 2, 2017)","PeriodicalId":20022,"journal":{"name":"Phosphorus Research Bulletin","volume":"5 1","pages":"21-25"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84364491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Colloidal manganese (Mn)-doped calcium hydroxyapatites (abbreviated as MnHap) were prepared by the coprecipitation method. The Mn/(Ca+Mn) atomic ratio in the solution (abbreviated as XMn) was varied from 0~0.30. The precipitated particles were characterized by various physicochemical analyses, i.e., TEM, XRD, N2 and H2O adsorptions, TG, FTIR, ICP-AES and XPS measurements. The MnHap particles were produced at 0.01≤XMn≤0.2. The calcium hydroxyapatite produced without Mn ions (XMn=0) was rod-like particles with 23 nm (width) x 55 nm (length). With increase in XMn up to 0.06, the particle width was decreased. The thickness of the rod-like particles produced at XMn≥0.08 was further decreased to ca. 3~5 nm. The spherical nano-particles with ca. 7 nm in diameter precipitated at XMn=0.3 were -TCP and amorphous particles of -MnOOH precursor. The particle color was varied from white to brown, dark-brown and pale-red. The ICP-AES measurement revealed that all the MnHap particles are cation-deficient with XMn values among 1.52~1.63. The lattice constants of c-axis was decreased with increase in XMn at XMn≥0.05 by incorporation of Mn(III) and Mn(IV) ions with smaller atomic radii, 0.072 and 0.053 nm, respectively, instead of Mn(II) ones (0.089 nm). The XPS measurement also revealed that there is no Mn(II) in the MnHap particles but they include both Mn(III) and Mn(IV) ions. The in vacuo IR measurements suggested that the incorporation of Mn ions increased the acidity of surface P-OH groups. (Received May 11, 2017; Accepted Oct 16, 2017)
{"title":"SYNTHESIS AND CHARACTERIZATION OF Mn-DOPED CALCIUM HYDROXYAPATITE PARTICLES","authors":"K. Kandori, Yuto Yamaguchi","doi":"10.3363/PRB.33.26","DOIUrl":"https://doi.org/10.3363/PRB.33.26","url":null,"abstract":"Colloidal manganese (Mn)-doped calcium hydroxyapatites (abbreviated as MnHap) were prepared by the coprecipitation method. The Mn/(Ca+Mn) atomic ratio in the solution (abbreviated as XMn) was varied from 0~0.30. The precipitated particles were characterized by various physicochemical analyses, i.e., TEM, XRD, N2 and H2O adsorptions, TG, FTIR, ICP-AES and XPS measurements. The MnHap particles were produced at 0.01≤XMn≤0.2. The calcium hydroxyapatite produced without Mn ions (XMn=0) was rod-like particles with 23 nm (width) x 55 nm (length). With increase in XMn up to 0.06, the particle width was decreased. The thickness of the rod-like particles produced at XMn≥0.08 was further decreased to ca. 3~5 nm. The spherical nano-particles with ca. 7 nm in diameter precipitated at XMn=0.3 were -TCP and amorphous particles of -MnOOH precursor. The particle color was varied from white to brown, dark-brown and pale-red. The ICP-AES measurement revealed that all the MnHap particles are cation-deficient with XMn values among 1.52~1.63. The lattice constants of c-axis was decreased with increase in XMn at XMn≥0.05 by incorporation of Mn(III) and Mn(IV) ions with smaller atomic radii, 0.072 and 0.053 nm, respectively, instead of Mn(II) ones (0.089 nm). The XPS measurement also revealed that there is no Mn(II) in the MnHap particles but they include both Mn(III) and Mn(IV) ions. The in vacuo IR measurements suggested that the incorporation of Mn ions increased the acidity of surface P-OH groups. (Received May 11, 2017; Accepted Oct 16, 2017)","PeriodicalId":20022,"journal":{"name":"Phosphorus Research Bulletin","volume":"11 1","pages":"26-34"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78279738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Preparation conditions of millimeter-scale fibrous octacalcium phosphate (Ca8H2(PO4)6·5H2O: OCP) particles by homogeneous precipitation method were examined, using Ca(NO3)2, (NH4)2HPO4, urea ((NH2)2CO; precipitant) and conc. HNO3 (precipitation inhibitor). The starting solution (200 cm) with 0.0266 mol∙dm Ca(NO3)2 and 0.0200 mol∙dm (NH4)2HPO4, i.e., the stoichiometric Ca/P ratio of OCP (=1.33), was heated under reflux at 80oC for 24 h in order to encourage the precipitation, due to the hydrolysis of urea to dissociate ammonia; however, the reaction products were not only OCP but also CaHPO4. The increase in Ca/P ratio and diluted concentrations of starting calcium phosphate solution made the formation of longer fibrous OCP particles possible, i.e., approximately 1000m of mean long-axis length due to the heating of 0.0500 mol∙dm Ca(NO3)2 and 0.0300 mol∙dm (NH4)2HPO4 solution (Ca/P ratio=1.67) under reflux and approximately 1200m due to the heating of 0.0500 mol∙dm Ca(NO3)2 and 0.0250 mol∙dm (NH4)2HPO4 solution (Ca/P ratio=2.00)), both using 0.20 mol∙dm urea. (Received Mar 26, 2017; Accepted Apr 20, 2017)
{"title":"Preparation of millimeter-scale fibrous octacalcium phosphate particles by homogeneous precipitation method","authors":"Ryuto Kuniya, K. Itatani","doi":"10.3363/PRB.33.14","DOIUrl":"https://doi.org/10.3363/PRB.33.14","url":null,"abstract":"Preparation conditions of millimeter-scale fibrous octacalcium phosphate (Ca8H2(PO4)6·5H2O: OCP) particles by homogeneous precipitation method were examined, using Ca(NO3)2, (NH4)2HPO4, urea ((NH2)2CO; precipitant) and conc. HNO3 (precipitation inhibitor). The starting solution (200 cm) with 0.0266 mol∙dm Ca(NO3)2 and 0.0200 mol∙dm (NH4)2HPO4, i.e., the stoichiometric Ca/P ratio of OCP (=1.33), was heated under reflux at 80oC for 24 h in order to encourage the precipitation, due to the hydrolysis of urea to dissociate ammonia; however, the reaction products were not only OCP but also CaHPO4. The increase in Ca/P ratio and diluted concentrations of starting calcium phosphate solution made the formation of longer fibrous OCP particles possible, i.e., approximately 1000m of mean long-axis length due to the heating of 0.0500 mol∙dm Ca(NO3)2 and 0.0300 mol∙dm (NH4)2HPO4 solution (Ca/P ratio=1.67) under reflux and approximately 1200m due to the heating of 0.0500 mol∙dm Ca(NO3)2 and 0.0250 mol∙dm (NH4)2HPO4 solution (Ca/P ratio=2.00)), both using 0.20 mol∙dm urea. (Received Mar 26, 2017; Accepted Apr 20, 2017)","PeriodicalId":20022,"journal":{"name":"Phosphorus Research Bulletin","volume":"66 1","pages":"14-20"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74597817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Keishi Kiminami, Kento Matsuoka, Toshiisa Konishi, Minori Mizumoto, M. Honda, Hidetoshi Arimura, M. Aizawa
We have previously developed a chelate-setting calcium-phosphate cement (CPC) consisting of hydroxyapatite (HAp) powders surface-modified with inositol hexaphosphate (IP6). In the present study, mechanically ball-milled α-tricalcium phosphate (α-TCP) powders were added into the IP6-HAp cement in order to enhance its anti-washout capability and mechanical properties. After optimization of the ball-milling conditions, the cement specimens mixed with various amounts of the prepared α-TCP powders were fabricated. Examinations of their mechanical properties revealed significant increase of compressive strength (CS) with the addition of the α-TCP powders. Further, it was demonstrated that the specimens of the IP6-HAp powders / the α-TCP powders mixing ratios of 20/80 and 30/70 [g/g] exhibited comparatively high anti-washout capability. In conclusion, these cements are promising chelate-setting CPCs with enhanced anti-washout capability and mechanical properties. (Received Feb 8, 2017; Accepted Mar 17, 2017)
{"title":"EFFECTS OF ADDITION OF α-TRICALCIUM PHOSPHATE POWDERS ON MATERIAL PROPERTIES OF THE CHELATE-SETTING HYDROXYAPATITE CEMENT","authors":"Keishi Kiminami, Kento Matsuoka, Toshiisa Konishi, Minori Mizumoto, M. Honda, Hidetoshi Arimura, M. Aizawa","doi":"10.3363/PRB.33.7","DOIUrl":"https://doi.org/10.3363/PRB.33.7","url":null,"abstract":"We have previously developed a chelate-setting calcium-phosphate cement (CPC) consisting of hydroxyapatite (HAp) powders surface-modified with inositol hexaphosphate (IP6). In the present study, mechanically ball-milled α-tricalcium phosphate (α-TCP) powders were added into the IP6-HAp cement in order to enhance its anti-washout capability and mechanical properties. After optimization of the ball-milling conditions, the cement specimens mixed with various amounts of the prepared α-TCP powders were fabricated. Examinations of their mechanical properties revealed significant increase of compressive strength (CS) with the addition of the α-TCP powders. Further, it was demonstrated that the specimens of the IP6-HAp powders / the α-TCP powders mixing ratios of 20/80 and 30/70 [g/g] exhibited comparatively high anti-washout capability. In conclusion, these cements are promising chelate-setting CPCs with enhanced anti-washout capability and mechanical properties. (Received Feb 8, 2017; Accepted Mar 17, 2017)","PeriodicalId":20022,"journal":{"name":"Phosphorus Research Bulletin","volume":"12 1","pages":"7-13"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83165789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Shakya, M. Murata, N. Okubo, H. Nagayasu, T. Akazawa
use 9pt): Healthy bone has many physiological microcracks, which may be involved in the release of bone matrix-derived factors and act to accelerate bone-remodeling process. In this study, the mouse parietal bone fragments (5x5x1mm) were demineralized by acidic electrolyzed water (AEW: pH2.7) or distilled water (DW: pH5.2) at 120W and 38KHz for 20 min. Each bone was implanted into subcutaneous tissue of 10 week-old male nude mouse, and explanted at 4 and 6 weeks. AEW-bone showed clear enlargement and union of cracks on SEM. AEW-bone revealed active bone induction over wide areas at 6 weeks, while DW-bone induced new bone in limited area. We concluded that the AEW-bone had better performance in bone induction than the DW-bone. Our micro-damage technique combined with AEW and the ultrasonic irradiation will contribute to improve surface area and 3D structure of the dense bone and promote bone formation in the initial stage for bone remodeling. (Received Jan 20, 2017; Accepted Mar 1, 2017)
{"title":"MICROCRACKS DESIGN AND BONE INDUCTION OF SKULL BONE MODIFIED BY ULTRASONIC TREATMENT USING ACIDIC ELECTROLYZED WATER","authors":"M. Shakya, M. Murata, N. Okubo, H. Nagayasu, T. Akazawa","doi":"10.3363/PRB.33.1","DOIUrl":"https://doi.org/10.3363/PRB.33.1","url":null,"abstract":"use 9pt): Healthy bone has many physiological microcracks, which may be involved in the release of bone matrix-derived factors and act to accelerate bone-remodeling process. In this study, the mouse parietal bone fragments (5x5x1mm) were demineralized by acidic electrolyzed water (AEW: pH2.7) or distilled water (DW: pH5.2) at 120W and 38KHz for 20 min. Each bone was implanted into subcutaneous tissue of 10 week-old male nude mouse, and explanted at 4 and 6 weeks. AEW-bone showed clear enlargement and union of cracks on SEM. AEW-bone revealed active bone induction over wide areas at 6 weeks, while DW-bone induced new bone in limited area. We concluded that the AEW-bone had better performance in bone induction than the DW-bone. Our micro-damage technique combined with AEW and the ultrasonic irradiation will contribute to improve surface area and 3D structure of the dense bone and promote bone formation in the initial stage for bone remodeling. (Received Jan 20, 2017; Accepted Mar 1, 2017)","PeriodicalId":20022,"journal":{"name":"Phosphorus Research Bulletin","volume":"10 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75798562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Y. Yokogawa, T. Murata, H. Yamada, K. Fujii, K. Tone, Y. Okada
Calcium phosphate cement (CPC) has biocompatibility and osteoconductive property, but it has some drawbacks, such as wash-out and rigid and brittle properties. Such drawbacks can be overcome by fast-setting and gelation of the CPC paste. The CPC powder is a mixture of tetracalcium phosphate and dicalcium phosphate dehydrate. A low or medium molecular weight chitosan (lowor med-chitosan) and malic acid solution were used in the liquid phase to develop fast-setting and high work-of-fracture CPC materials. The incorporation of 1.25 2.5 wt% chitosan increased a tripled work-of-fracture to 12.0 kJ/m when not using chitosan. The setting time was 2.8±0.3 min and 5.5±0.5 min when 2.5 wt% lowor med-chitosan was used, respectively. The "non-rigid” and “fast-setting" CPC cement was successfully obtained by adding chitosan and malic acid to the liquid phase, and the incorporation of med-chitosan may produce a high work-of-fracture and stable CPC with a desirable setting time. (Received March 31, 2016; Accepted May 2, 2016)
磷酸钙水泥(CPC)具有生物相容性和骨导电性，但也存在冲刷、硬脆等缺点。这些缺点可以通过CPC膏体的快速凝固和凝胶化来克服。CPC粉末是磷酸四钙和脱水磷酸二钙的混合物。采用低分子量或中等分子量的壳聚糖(low - medium -chitosan)和苹果酸溶液作为液相，制备了快速凝固和高压裂作业能力的CPC材料。在不使用壳聚糖的情况下，1.25 - 2.5 wt%的壳聚糖的掺入使压裂功增加了三倍，达到12.0 kJ/m。2.5%低浓度壳聚糖的凝固时间分别为2.8±0.3 min和5.5±0.5 min。通过在液相中加入壳聚糖和苹果酸，成功地获得了“非刚性”和“快凝”CPC水泥，并且中壳聚糖的掺入可以产生高压裂功和稳定的CPC，并且具有理想的凝结时间。(2016年3月31日收稿;2016年5月2日录用)
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