Photodermatology, photoimmunology & photomedicine最新文献

英文中文

Carcinogenic risk in patients treated with UVA-1 phototherapy: A 5-year retrospective study. 接受 UVA-1 光疗患者的致癌风险：一项为期 5 年的回顾性研究。

IF 2.6 4区医学 Q2 DERMATOLOGY

Photodermatology, photoimmunology & photomedicine

Pub Date : 2024-05-01 DOI: 10.1111/phpp.12975

Davide Cosetti, Vittoria Cioppa, Pietro Rubegni, Emanuele Trovato

Background: UVA-1 phototherapy was first used to treat atopic dermatitis and afterwards to several other skin diseases. The contribution of UVA-1 in human photocarcinogenesis, skin photoaging, immune suppression, and hyperpigmentation is now well established. The actual contribution of UVA-1 radiation to the development of malignant melanoma (MM) in humans cannot be excluded.

Purpose: The aim of the study is to evaluate the risk of developing skin cancers (non-melanoma skin cancers (NMSCs) and MM) in patients treated with UVA-1 phototherapy with a 5-year dermatological follow-up.

Methods: We conducted a retrospective cohort study with 31 patients with morphea and atopic dermatitis treated with medium dose UVA-1 phototherapy (34 J/cm²). All enrolled patients underwent an oncologic prevention visit annually with a 5-year follow-up with clinical evaluation of the entire skin surface.

Results: During the 5-year follow-up, we recorded a case of basal cell carcinoma (BCC) in the cervical region and one case of MM on the back (pT1a). In both cases, the patients were female and affected by morphea. The Glogau 3 group is prevalent (42%), which is consistent with moderate to severe aging; the data appear to be compatible with the age.

Conclusions: This study attests that medium-dose UVA-1 phototherapy does not increase the risk of developing skin tumors and that UVA-1 phototherapy is not a worsening factor of facial photoaging. The main limitation of the study is the small sample size, avoiding to obtain statistically significant values. It was not possible to analyze individually the actual daily sun exposure during the 5-year observation period and to correlate it in terms of time and tumor development. Further studies with large sample sizes will be needed to confirm our data. Our study reaffirms how the dermatological examination performed annually is essential in the follow-up of patients undergoing this type of therapy.

背景：UVA-1 光疗最早用于治疗特应性皮炎，后来又用于治疗其他几种皮肤病。现在，UVA-1 在人类光致癌、皮肤光老化、免疫抑制和色素沉着方面的作用已得到公认。目的：本研究旨在评估接受 UVA-1 光疗的患者罹患皮肤癌（非黑色素瘤皮肤癌（NMSCs）和 MM）的风险，并进行为期 5 年的皮肤病学随访：我们对 31 名接受中等剂量 UVA-1 光疗（34 J/cm2）的斑秃和特应性皮炎患者进行了回顾性队列研究。所有入组患者每年接受一次肿瘤预防检查，并进行为期 5 年的随访，对整个皮肤表面进行临床评估：在为期 5 年的随访中，我们发现一例颈部基底细胞癌（BCC）和一例背部 MM（pT1a）。这两例患者均为女性，并患有斑秃。格洛高 3 组发病率高（42%），与中度至重度衰老相符；数据似乎与年龄相符：这项研究证明，中等剂量的 UVA-1 光疗不会增加罹患皮肤肿瘤的风险，UVA-1 光疗也不是导致面部光老化的恶化因素。这项研究的主要局限性在于样本量较小，无法获得具有统计学意义的数值。研究无法对 5 年观察期内每天实际日晒情况进行单独分析，也无法将日晒时间与肿瘤发展联系起来。要确认我们的数据，还需要进行更多的大样本研究。我们的研究再次证明，每年进行一次皮肤科检查对接受此类治疗的患者的随访至关重要。

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引用次数: 0

Comparing the efficacy of 308-nm light-emitting diode and 308-nm excimer lamp for treating vitiligo: A randomized controlled trial. 比较 308 纳米发光二极管和 308 纳米准分子灯治疗白癜风的疗效：随机对照试验。

IF 2.5 4区医学 Q2 DERMATOLOGY

Photodermatology, photoimmunology & photomedicine

Pub Date : 2024-05-01 DOI: 10.1111/phpp.12972

Yu Hu, Lihao Liu, Zhuohong Xu, Dan Huang, Hongying Chen, Jiaan Zhang, Lihao Chen, Xiaoxi Dai, Liangliang Zhang, Chao Luan, Mei Ju, Kun Chen

Background: In previous studies, the 308-nm light-emitting diode (LED) has been proven safe and effective for treating vitiligo. However, direct comparisons between the 308-nm LED and 308-nm excimer lamp (308-nm MEL) for the treatment of vitiligo are lacking.

Objective: To compare the efficacy of the 308-nm LED and 308-nm MEL for treating nonsegmental stable vitiligo.

Patients and methods: This randomized controlled trial was conducted between January 2018 and August 2023. Enrolled patients were randomly assigned to either the 308-nm LED or the 308-nm MEL groups, both receiving 16 treatment sessions. Adverse events that occurred during the treatment were documented.

Results: In total, 269 stable vitiligo patches from 174 patients completed the study. A total of 131 lesions were included in the 308-nm LED group, and 138 lesions were included in the 308-nm MEL group. After 16 treatment sessions, 38.17% of the vitiligo patches in the 308-nm LED group achieved repigmentation of at least 50% versus 38.41% in the 308-nm MEL group. The two devices exhibited similar results in terms of efficacy for a repigmentation of at least 50% (p = .968). The incidence of adverse effects with the two phototherapy devices was comparable (p = .522).

Conclusions: Treatment of vitiligo with the 308-nm LED had a similar efficacy rate to the 308-nm MEL, and the incidence of adverse effects was comparable between the two devices.

背景：在以往的研究中，308纳米发光二极管（LED）已被证明对治疗白癜风安全有效。然而，308 纳米 LED 和 308 纳米准分子灯（308-nm MEL）在治疗白癜风方面还缺乏直接比较：比较 308 纳米 LED 和 308 纳米 MEL 治疗非节段性稳定期白癜风的疗效：这项随机对照试验于2018年1月至2023年8月期间进行。入组患者被随机分配到 308-nm LED 组或 308-nm MEL 组，均接受 16 次治疗。治疗期间发生的不良事件均有记录：共有 174 名患者的 269 个稳定期白癜风斑块完成了研究。308-nm LED 组共有 131 个皮损，308-nm MEL 组共有 138 个皮损。经过 16 次治疗后，308 纳米 LED 组有 38.17% 的白癜风斑块达到了至少 50% 的再色素沉着，而 308 纳米 MEL 组则为 38.41%。两种设备在色素恢复至少50%方面的疗效相似（p = 0.968）。两种光疗设备的不良反应发生率相当（p = .522）：结论：308 纳米 LED 治疗白癜风的有效率与 308 纳米 MEL 相似，两种设备的不良反应发生率相当。

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引用次数: 0

Combination of 308‐nm excimer laser and piperine promotes melanocyte proliferation, migration, and melanin content production via the miR‐328/SFRP1 axis 308 纳米准分子激光与胡椒碱的结合可通过 miR-328/SFRP1 轴促进黑色素细胞的增殖、迁移和黑色素含量的生成

IF 2.6 4区医学 Q2 DERMATOLOGY

Photodermatology, photoimmunology & photomedicine

Pub Date : 2024-04-30 DOI: 10.1111/phpp.12970

Yifei Wu, Jiayu Zhang, Sha Du, Xiaochuan Wang, Jinrong Li, Yi Chen, Hongying Zhou, Su Gao, Yongrong Li, Xiuhong Liu

ObjectiveBoth piperine and a 308‐nm excimer laser have significant curative effects on vitiligo. This study mainly explored the molecular mechanism of a 308‐nm excimer combined with piperine in regulating melanocyte proliferation.MethodsEpidermal melanocytes were cultured in piperine solution, and the cells were irradiated by an XTRAC excimer laser treatment system at 308‐nm output monochromatic light. Quantitative real‐time polymerase chain reaction (qRT–PCR) and Western blot were for detecting the expression levels of genes or proteins. The 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyl tetrazolium bromide (MTT) and Transwell method was for assessing cell viability and migration capacity. The content of melanin was also detected.ResultsThe combination of the 308‐nm excimer laser and piperine enhanced the cell proliferation, migration, and melanin production of melanocytes and upregulated the level of miR‐328, and restraint of miR‐328 reversed the influence of the 308‐nm excimer laser and piperine. Secreted frizzled‐related protein 1 (SFRP1) is a direct target gene of miR‐328, and miR‐328 can inhibit the expression of SFRP1 and elevate the protein level of the Wnt/β‐catenin signaling pathway.ConclusionThe 308‐nm excimer laser combined with piperine may be more efficient than piperine alone in the remedy of vitiligo, and the miR‐328/SFRP1 and Wnt/β‐catenin pathways are participated in the proliferation, migration, and melanin synthesis of melanocytes.

目的哌啶和308 nm准分子激光对白癜风均有显著疗效。方法将表皮黑色素细胞置于哌啶溶液中培养，用 XTRAC 准分子激光治疗系统照射输出波长为 308nm 的单色光。定量实时聚合酶链反应（qRT-PCR）和 Western 印迹法用于检测基因或蛋白质的表达水平。3-(4,5-二甲基噻唑-2-基)-2,5-二苯基溴化四氮唑（MTT）和 Transwell 法用于评估细胞活力和迁移能力。结果 308-nm 准分子激光和胡椒碱联合使用可增强黑色素细胞的增殖、迁移和黑色素生成，并上调 miR-328 的水平，而抑制 miR-328 则可逆转 308-nm 准分子激光和胡椒碱的影响。分泌型frizzled相关蛋白1（SFRP1）是miR-328的直接靶基因，miR-328能抑制SFRP1的表达，提高Wnt/β-catenin信号通路的蛋白水平。结论 308-nm准分子激光联合哌啶治疗白癜风可能比单独使用哌啶更有效，miR-328/SFRP1和Wnt/β-catenin通路参与了黑色素细胞的增殖、迁移和黑色素合成。

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引用次数: 0

Characteristics of dermatology practices accepting Medicaid for phototherapy in the United States: A comprehensive nationwide cross‐sectional analysis 美国接受医疗补助计划（Medicaid）光疗的皮肤科诊所的特点：全国性横断面综合分析

IF 2.6 4区医学 Q2 DERMATOLOGY

Photodermatology, photoimmunology & photomedicine

Pub Date : 2024-04-30 DOI: 10.1111/phpp.12973

Seda Sahin, Eric J. Beltrami, Hao Feng

引用次数: 0

Inhibition of UVB radiation‐induced tissue swelling and immune suppression by nicotinamide riboside and pterostilbene 烟酰胺核苷和紫檀芪抑制紫外线辐射引起的组织肿胀和免疫抑制

IF 2.6 4区医学 Q2 DERMATOLOGY

Photodermatology, photoimmunology & photomedicine

Pub Date : 2024-04-27 DOI: 10.1111/phpp.12961

Verena Isak, Shayan Azizi, Xi K. Zhou, Devina Mehta, Wanhong Ding, Zakir Bulmer, Daniella S. Aivazi, Ryan W. Dellinger, Richard D. Granstein

BackgroundEnvironmental ultraviolet radiation has deleterious effects on humans, including sunburn and immune perturbations. These immune changes are involved in skin carcinogenesis.ObjectivesTo determine whether nicotinamide riboside and/or pterostilbene administered systemically inhibits inflammatory and immune effects of exposure to mid‐range ultraviolet radiation.MethodsTo examine UVB radiation‐induced inflammatory effects, mice were fed standard chow/water, 0.04% pterostilbene in chow and 0.2% nicotinamide riboside in drinking water, diet with nicotinamide riboside alone, or diet with pterostilbene alone. After 4 weeks, mice were exposed to UVB radiation (3500 J/m2), and 24‐/48‐h ear swelling was assessed. We also asked if each agent or the combination inhibits UVB radiation suppression of contact hypersensitivity in two models. Mice were fed standard diet/water or chow containing 0.08% pterostilbene, water with 0.4% nicotinamide riboside, or both for 4 weeks. Low‐dose: Half the mice in each group were exposed on the depilated dorsum to UVB radiation (1700 J/m2) daily for 4 days, whereas half were mock‐irradiated. Mice were immunized on the exposed dorsum to dinitrofluorobenzene 4 h after the last irradiation, challenged 7 days later on the ears with dinitrofluorobenzene, and 24‐h ear swelling assessed. High dose: Mice were treated similarly except that a single dose of 10,000 J/m2 of radiation was administered and immunization was performed on the unirradiated shaved abdomen 3 days later.ResultsNicotinamide riboside and pterostilbene together inhibited UVB‐induced skin swelling more than either alone. Pterostilbene alone and both given together could inhibit UVB‐induced immune suppression in both the low‐dose and high‐dose models while nicotinamide riboside alone was more effective in the low‐dose model than the high‐dose model.ConclusionNicotinamide riboside and pterostilbene have protective effects against UVB radiation‐induced tissue swelling and immune suppression.

背景环境紫外线辐射会对人体产生有害影响，包括晒伤和免疫紊乱。方法为了研究 UVB 辐射引起的炎症效应，小鼠被喂食标准饲料/水、饲料中含 0.04% 紫檀芪和饮用水中含 0.2% 尼古丁酰胺核苷的食物、仅含尼古丁酰胺核苷的食物或仅含紫檀芪的食物。4 周后，将小鼠暴露于 UVB 辐射（3500 J/m2），并评估 24/48 小时的耳肿胀情况。我们还询问了在两种模型中，每种制剂或其组合是否能抑制紫外线辐射对接触过敏的抑制作用。给小鼠喂食标准饮食/水或含有 0.08% 紫檀芪的饲料、含有 0.4% 烟酸核苷的水或两者，持续 4 周。低剂量：每组一半的小鼠每天将脱毛后的背部暴露于紫外线辐射（1700 J/m2），持续 4 天，另一半小鼠则接受模拟辐射。在最后一次照射后 4 小时，用二硝基氟苯对小鼠受照射的背部进行免疫，7 天后用二硝基氟苯对小鼠的耳朵进行挑战，并评估 24 小时的耳朵肿胀情况。高剂量：结果烟酰胺核糖甙和紫檀芪共同抑制 UVB 引起的皮肤肿胀的效果优于单独使用其中一种。结论烟酰胺核苷和紫檀芪对紫外线辐射引起的组织肿胀和免疫抑制具有保护作用。

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引用次数: 0

Phototherapy for vitiligo: A narrative review on the clinical and molecular aspects, and recent literature 白癜风的光疗：临床和分子方面的叙述性综述以及最新文献

IF 2.6 4区医学 Q2 DERMATOLOGY

Photodermatology, photoimmunology & photomedicine

Pub Date : 2024-04-18 DOI: 10.1111/phpp.12968

Anuradha Bishnoi, Davinder Parsad

BackgroundVitiligo is characterized by depigmented patches resulting from loss of melanocytes. Phototherapy has emerged as a prominent treatment option for vitiligo, utilizing various light modalities to induce disease stability and repigmentation.Aims and MethodsThis narrative review aims to explore the clinical applications and molecular mechanisms of phototherapy in vitiligo.Results and DiscussionThe review evaluates existing literature on phototherapy for vitiligo, analyzing studies on hospital‐based and home‐based phototherapy, as well as outcomes related to stabilization and repigmentation. Narrowband ultra‐violet B, that is, NBUVB remains the most commonly employed, studied and effective phototherapy modality for vitiligo. Special attention is given to assessing different types of lamps, dosimetry, published guidelines, and the utilization of targeted phototherapy modalities. Additionally, the integration of phototherapy with other treatment modalities, including its use as a depigmenting therapy in generalized/universal vitiligo, is discussed. Screening for anti‐nuclear antibodies and tailoring approaches for non‐photo‐adapters are also examined.ConclusionIn conclusion, this review provides a comprehensive overview of phototherapy for vitiligo treatment. It underscores the evolving landscape of phototherapy and offers insights into optimizing therapeutic outcomes and addressing the challenges ahead. By integrating clinical evidence with molecular understanding, phototherapy emerges as a valuable therapeutic option for managing vitiligo, with potential for further advancements in the field.

背景白癜风的特征是黑色素细胞脱失导致的色素脱失斑。光疗已成为治疗白癜风的一种重要方法，它利用各种光照模式诱导疾病稳定和再色素沉着。结果与讨论该综述评估了现有的白癜风光疗文献，分析了基于医院和家庭的光疗研究，以及与疾病稳定和再色素沉着相关的结果。窄带紫外线 B（即 NBUVB）仍然是白癜风光疗中最常用、最受研究、最有效的方法。本研究特别关注对不同类型的灯管、剂量测定、已发布的指南以及有针对性的光疗方法的使用进行评估。此外，还讨论了光疗与其他治疗方式的结合，包括将其用作泛发型/全身型白癜风的脱色疗法。结论综上所述，本综述全面概述了用于白癜风治疗的光疗。它强调了光疗不断发展的前景，并为优化治疗效果和应对未来挑战提供了见解。通过将临床证据与分子认识相结合，光疗已成为治疗白癜风的一种有价值的治疗方法，并有可能在该领域取得进一步的进展。

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引用次数: 0

Effect of education on sun‐safe behaviour in kidney transplant recipients 教育对肾移植受者防晒行为的影响

IF 2.6 4区医学 Q2 DERMATOLOGY

Photodermatology, photoimmunology & photomedicine

Pub Date : 2024-04-15 DOI: 10.1111/phpp.12966

Vanessza Tári, Eszter Anna Janka, Gabriella Emri, Balázs Nemes, Éva Remenyik, Emese Gellén

BackgroundOrgan transplant recipients (OTR) are more likely to develop skin cancer than the general population. One of the main components of the exposome that triggers the development of skin tumours is solar ultraviolet (UV) radiation. To reduce the incidence of harmful consequences of sun exposure, sun protection education is needed for patients taking long‐term immunosuppressive drugs.MethodsIn a previous study, we assessed the sun‐safe behaviour of 221 OTR using a questionnaire before and after transplantation and personally educated the patients about proper sun protection. After the education, there were no further reminder presentations. Presently, the sun protection and sun seeking habits of the available 176 of these patients were questioned to assess the long‐term effect of the previous sun protection education.ResultsTwo‐four years after the education, more patients wore hats and protected their skin with long‐sleeved clothing than before the education. In terms of sun seeking habits, both occupational and recreational sun exposure decreased significantly. Significantly fewer people went on holiday after transplantation, but those who went on holiday spent significantly less time in the sun.ConclusionThe long‐term positive effects of education can be seen both in the patients' sun protection and in their sun seeking habits. However, the long‐term goal is to maintain these results and thereby reduce the likelihood of skin tumours and consequently the associated tumour death.

背景器官移植受者（OTR）比普通人更容易患皮肤癌。太阳紫外线（UV）辐射是诱发皮肤肿瘤的暴露体的主要成分之一。为了减少日光照射造成的有害后果，需要对长期服用免疫抑制剂的患者进行防晒教育。教育结束后，我们没有再对患者进行提醒。目前，我们对其中 176 名患者的防晒和寻求阳光的习惯进行了调查，以评估之前防晒教育的长期效果。从晒太阳的习惯来看，职业性和娱乐性晒太阳的情况都明显减少。移植后去度假的人数明显减少，但去度假的人在阳光下曝晒的时间也明显减少。然而，长期目标是保持这些效果，从而降低皮肤肿瘤的可能性，并减少相关的肿瘤死亡。

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引用次数: 0

New trends on personalized sunscreens 个性化防晒霜的新趋势

IF 2.6 4区医学 Q2 DERMATOLOGY

Photodermatology, photoimmunology & photomedicine

Pub Date : 2024-04-15 DOI: 10.1111/phpp.12967

Tamara Gracia‐Cazaña, José Aguilera, Alba Navarro‐Bielsa, Salvador González, Henry W. Lim, Yolanda Gilaberte

Background/PurposeNowadays, there are emerging trends in customized and personalized photoprotection, focusing on the innovative approaches to enhance sun protection efficacy tailored to individual needs.MethodsWe conducted an electronic search of the following databases: MEDLINE, EMBASE, Cochrane Database of Systematic Reviews, Cochrane Skin Group Specialised Skin Register, and TESEO. Specific search terms related to personalized photoprotection and the variables of age, genetic predisposition, skin phototype, photodermatosis, and physiological conditions such as pregnancy, as well as lifestyle habits were used.Results/ConclusionThe article highlights the challenges and opportunities in adopting personalized photoprotection strategies, aiming to promote skin health and prevent the harmful effects of UV radiation in the era of precision medicine.

背景/目的如今，定制化和个性化防晒已成为一种新兴趋势，其重点是根据个人需求采用创新方法来提高防晒效果：我们对以下数据库进行了电子检索：MEDLINE、EMBASE、Cochrane 系统综述数据库、Cochrane 皮肤组专业皮肤登记册和 TESEO。结果/结论这篇文章强调了在精准医学时代，采用个性化光防护策略的挑战和机遇，旨在促进皮肤健康和预防紫外线辐射的有害影响。

引用次数: 0

Phototherapy for pigmentary disorders 色素性疾病的光疗

IF 2.6 4区医学 Q2 DERMATOLOGY

Photodermatology, photoimmunology & photomedicine

Pub Date : 2024-04-15 DOI: 10.1111/phpp.12963

Hee Young Kang

CONFLICT OF INTEREST STATEMENT

The author declares no conflicts of interest.

利益冲突声明作者声明没有利益冲突。

引用次数: 0

Efficacy and safety of excimer light (308 nm) in the treatment of pityriasis lichenoides chronica 准分子光（308 纳米）治疗慢性脓疱性苔藓的有效性和安全性

IF 2.6 4区医学 Q2 DERMATOLOGY

Photodermatology, photoimmunology & photomedicine

Pub Date : 2024-04-15 DOI: 10.1111/phpp.12964

Eman Mohamed Salah, Nermeen Ibrahim Bedair, Sarah Khalil Abd El‐Rahim, Mohammed Ahmed El‐Khalawany

IntroductionPityriasis lichenoides chronica is the chronic end of the spectrum of pityriasis lichenoides which have several forms of papulosuamous conditions. Several treatments obtained complete clearance of the condition including phototherapy and specifically narrow band ultraviolet B. The Excimer light 308 is a monochromatic light that acts within the ultraviolet B wavelength and used as a targeted phototherapy in several skin conditions.MethodsThirty‐four patients with histopathologically diagnosed pityriasis lichenoides chronica underwent treatment with biweekly sessions of excimer light 308 nm. Treatment continued until complete clearance was obtained or to a maximum of 48 sessions (24 weeks).ResultsThirty‐one patients obtained complete clearance with no recurrence till the end of the study period, two patients had partial response and only one patient showed poor response to treatment.ConclusionExcimer light can be a safe and effective treatment of pityriasis lichinoides chronica in different ages and genders.

导言：慢性斑丘疹性苔藓是斑丘疹性苔藓的慢性病，它有多种形式的丘疹脓疱病。准分子光 308 是一种单色光，其波长在紫外线 B 波段内，可用于多种皮肤病的靶向光疗。方法34 名经组织病理学诊断为慢性斑癣的患者每两周接受一次准分子光 308 nm 治疗。结果31名患者完全痊愈，直到研究结束也没有复发，2名患者有部分反应，只有1名患者对治疗反应不佳。

引用次数: 0

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