Photodermatology, photoimmunology & photomedicine最新文献

英文中文

Characteristics of dermatology practices accepting Medicaid for phototherapy in the United States: A comprehensive nationwide cross‐sectional analysis 美国接受医疗补助计划（Medicaid）光疗的皮肤科诊所的特点：全国性横断面综合分析

IF 2.6 4区医学 Q2 DERMATOLOGY

Photodermatology, photoimmunology & photomedicine

Pub Date : 2024-04-30 DOI: 10.1111/phpp.12973

Seda Sahin, Eric J. Beltrami, Hao Feng

引用次数: 0

Inhibition of UVB radiation‐induced tissue swelling and immune suppression by nicotinamide riboside and pterostilbene 烟酰胺核苷和紫檀芪抑制紫外线辐射引起的组织肿胀和免疫抑制

IF 2.6 4区医学 Q2 DERMATOLOGY

Photodermatology, photoimmunology & photomedicine

Pub Date : 2024-04-27 DOI: 10.1111/phpp.12961

Verena Isak, Shayan Azizi, Xi K. Zhou, Devina Mehta, Wanhong Ding, Zakir Bulmer, Daniella S. Aivazi, Ryan W. Dellinger, Richard D. Granstein

BackgroundEnvironmental ultraviolet radiation has deleterious effects on humans, including sunburn and immune perturbations. These immune changes are involved in skin carcinogenesis.ObjectivesTo determine whether nicotinamide riboside and/or pterostilbene administered systemically inhibits inflammatory and immune effects of exposure to mid‐range ultraviolet radiation.MethodsTo examine UVB radiation‐induced inflammatory effects, mice were fed standard chow/water, 0.04% pterostilbene in chow and 0.2% nicotinamide riboside in drinking water, diet with nicotinamide riboside alone, or diet with pterostilbene alone. After 4 weeks, mice were exposed to UVB radiation (3500 J/m2), and 24‐/48‐h ear swelling was assessed. We also asked if each agent or the combination inhibits UVB radiation suppression of contact hypersensitivity in two models. Mice were fed standard diet/water or chow containing 0.08% pterostilbene, water with 0.4% nicotinamide riboside, or both for 4 weeks. Low‐dose: Half the mice in each group were exposed on the depilated dorsum to UVB radiation (1700 J/m2) daily for 4 days, whereas half were mock‐irradiated. Mice were immunized on the exposed dorsum to dinitrofluorobenzene 4 h after the last irradiation, challenged 7 days later on the ears with dinitrofluorobenzene, and 24‐h ear swelling assessed. High dose: Mice were treated similarly except that a single dose of 10,000 J/m2 of radiation was administered and immunization was performed on the unirradiated shaved abdomen 3 days later.ResultsNicotinamide riboside and pterostilbene together inhibited UVB‐induced skin swelling more than either alone. Pterostilbene alone and both given together could inhibit UVB‐induced immune suppression in both the low‐dose and high‐dose models while nicotinamide riboside alone was more effective in the low‐dose model than the high‐dose model.ConclusionNicotinamide riboside and pterostilbene have protective effects against UVB radiation‐induced tissue swelling and immune suppression.

背景环境紫外线辐射会对人体产生有害影响，包括晒伤和免疫紊乱。方法为了研究 UVB 辐射引起的炎症效应，小鼠被喂食标准饲料/水、饲料中含 0.04% 紫檀芪和饮用水中含 0.2% 尼古丁酰胺核苷的食物、仅含尼古丁酰胺核苷的食物或仅含紫檀芪的食物。4 周后，将小鼠暴露于 UVB 辐射（3500 J/m2），并评估 24/48 小时的耳肿胀情况。我们还询问了在两种模型中，每种制剂或其组合是否能抑制紫外线辐射对接触过敏的抑制作用。给小鼠喂食标准饮食/水或含有 0.08% 紫檀芪的饲料、含有 0.4% 烟酸核苷的水或两者，持续 4 周。低剂量：每组一半的小鼠每天将脱毛后的背部暴露于紫外线辐射（1700 J/m2），持续 4 天，另一半小鼠则接受模拟辐射。在最后一次照射后 4 小时，用二硝基氟苯对小鼠受照射的背部进行免疫，7 天后用二硝基氟苯对小鼠的耳朵进行挑战，并评估 24 小时的耳朵肿胀情况。高剂量：结果烟酰胺核糖甙和紫檀芪共同抑制 UVB 引起的皮肤肿胀的效果优于单独使用其中一种。结论烟酰胺核苷和紫檀芪对紫外线辐射引起的组织肿胀和免疫抑制具有保护作用。

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引用次数: 0

Phototherapy for vitiligo: A narrative review on the clinical and molecular aspects, and recent literature 白癜风的光疗：临床和分子方面的叙述性综述以及最新文献

IF 2.6 4区医学 Q2 DERMATOLOGY

Photodermatology, photoimmunology & photomedicine

Pub Date : 2024-04-18 DOI: 10.1111/phpp.12968

Anuradha Bishnoi, Davinder Parsad

BackgroundVitiligo is characterized by depigmented patches resulting from loss of melanocytes. Phototherapy has emerged as a prominent treatment option for vitiligo, utilizing various light modalities to induce disease stability and repigmentation.Aims and MethodsThis narrative review aims to explore the clinical applications and molecular mechanisms of phototherapy in vitiligo.Results and DiscussionThe review evaluates existing literature on phototherapy for vitiligo, analyzing studies on hospital‐based and home‐based phototherapy, as well as outcomes related to stabilization and repigmentation. Narrowband ultra‐violet B, that is, NBUVB remains the most commonly employed, studied and effective phototherapy modality for vitiligo. Special attention is given to assessing different types of lamps, dosimetry, published guidelines, and the utilization of targeted phototherapy modalities. Additionally, the integration of phototherapy with other treatment modalities, including its use as a depigmenting therapy in generalized/universal vitiligo, is discussed. Screening for anti‐nuclear antibodies and tailoring approaches for non‐photo‐adapters are also examined.ConclusionIn conclusion, this review provides a comprehensive overview of phototherapy for vitiligo treatment. It underscores the evolving landscape of phototherapy and offers insights into optimizing therapeutic outcomes and addressing the challenges ahead. By integrating clinical evidence with molecular understanding, phototherapy emerges as a valuable therapeutic option for managing vitiligo, with potential for further advancements in the field.

背景白癜风的特征是黑色素细胞脱失导致的色素脱失斑。光疗已成为治疗白癜风的一种重要方法，它利用各种光照模式诱导疾病稳定和再色素沉着。结果与讨论该综述评估了现有的白癜风光疗文献，分析了基于医院和家庭的光疗研究，以及与疾病稳定和再色素沉着相关的结果。窄带紫外线 B（即 NBUVB）仍然是白癜风光疗中最常用、最受研究、最有效的方法。本研究特别关注对不同类型的灯管、剂量测定、已发布的指南以及有针对性的光疗方法的使用进行评估。此外，还讨论了光疗与其他治疗方式的结合，包括将其用作泛发型/全身型白癜风的脱色疗法。结论综上所述，本综述全面概述了用于白癜风治疗的光疗。它强调了光疗不断发展的前景，并为优化治疗效果和应对未来挑战提供了见解。通过将临床证据与分子认识相结合，光疗已成为治疗白癜风的一种有价值的治疗方法，并有可能在该领域取得进一步的进展。

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引用次数: 0

Effect of education on sun‐safe behaviour in kidney transplant recipients 教育对肾移植受者防晒行为的影响

IF 2.6 4区医学 Q2 DERMATOLOGY

Photodermatology, photoimmunology & photomedicine

Pub Date : 2024-04-15 DOI: 10.1111/phpp.12966

Vanessza Tári, Eszter Anna Janka, Gabriella Emri, Balázs Nemes, Éva Remenyik, Emese Gellén

BackgroundOrgan transplant recipients (OTR) are more likely to develop skin cancer than the general population. One of the main components of the exposome that triggers the development of skin tumours is solar ultraviolet (UV) radiation. To reduce the incidence of harmful consequences of sun exposure, sun protection education is needed for patients taking long‐term immunosuppressive drugs.MethodsIn a previous study, we assessed the sun‐safe behaviour of 221 OTR using a questionnaire before and after transplantation and personally educated the patients about proper sun protection. After the education, there were no further reminder presentations. Presently, the sun protection and sun seeking habits of the available 176 of these patients were questioned to assess the long‐term effect of the previous sun protection education.ResultsTwo‐four years after the education, more patients wore hats and protected their skin with long‐sleeved clothing than before the education. In terms of sun seeking habits, both occupational and recreational sun exposure decreased significantly. Significantly fewer people went on holiday after transplantation, but those who went on holiday spent significantly less time in the sun.ConclusionThe long‐term positive effects of education can be seen both in the patients' sun protection and in their sun seeking habits. However, the long‐term goal is to maintain these results and thereby reduce the likelihood of skin tumours and consequently the associated tumour death.

背景器官移植受者（OTR）比普通人更容易患皮肤癌。太阳紫外线（UV）辐射是诱发皮肤肿瘤的暴露体的主要成分之一。为了减少日光照射造成的有害后果，需要对长期服用免疫抑制剂的患者进行防晒教育。教育结束后，我们没有再对患者进行提醒。目前，我们对其中 176 名患者的防晒和寻求阳光的习惯进行了调查，以评估之前防晒教育的长期效果。从晒太阳的习惯来看，职业性和娱乐性晒太阳的情况都明显减少。移植后去度假的人数明显减少，但去度假的人在阳光下曝晒的时间也明显减少。然而，长期目标是保持这些效果，从而降低皮肤肿瘤的可能性，并减少相关的肿瘤死亡。

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引用次数: 0

New trends on personalized sunscreens 个性化防晒霜的新趋势

IF 2.6 4区医学 Q2 DERMATOLOGY

Photodermatology, photoimmunology & photomedicine

Pub Date : 2024-04-15 DOI: 10.1111/phpp.12967

Tamara Gracia‐Cazaña, José Aguilera, Alba Navarro‐Bielsa, Salvador González, Henry W. Lim, Yolanda Gilaberte

Background/PurposeNowadays, there are emerging trends in customized and personalized photoprotection, focusing on the innovative approaches to enhance sun protection efficacy tailored to individual needs.MethodsWe conducted an electronic search of the following databases: MEDLINE, EMBASE, Cochrane Database of Systematic Reviews, Cochrane Skin Group Specialised Skin Register, and TESEO. Specific search terms related to personalized photoprotection and the variables of age, genetic predisposition, skin phototype, photodermatosis, and physiological conditions such as pregnancy, as well as lifestyle habits were used.Results/ConclusionThe article highlights the challenges and opportunities in adopting personalized photoprotection strategies, aiming to promote skin health and prevent the harmful effects of UV radiation in the era of precision medicine.

背景/目的如今，定制化和个性化防晒已成为一种新兴趋势，其重点是根据个人需求采用创新方法来提高防晒效果：我们对以下数据库进行了电子检索：MEDLINE、EMBASE、Cochrane 系统综述数据库、Cochrane 皮肤组专业皮肤登记册和 TESEO。结果/结论这篇文章强调了在精准医学时代，采用个性化光防护策略的挑战和机遇，旨在促进皮肤健康和预防紫外线辐射的有害影响。

引用次数: 0

Phototherapy for pigmentary disorders 色素性疾病的光疗

IF 2.6 4区医学 Q2 DERMATOLOGY

Photodermatology, photoimmunology & photomedicine

Pub Date : 2024-04-15 DOI: 10.1111/phpp.12963

Hee Young Kang

CONFLICT OF INTEREST STATEMENT

The author declares no conflicts of interest.

利益冲突声明作者声明没有利益冲突。

引用次数: 0

Efficacy and safety of excimer light (308 nm) in the treatment of pityriasis lichenoides chronica 准分子光（308 纳米）治疗慢性脓疱性苔藓的有效性和安全性

IF 2.6 4区医学 Q2 DERMATOLOGY

Photodermatology, photoimmunology & photomedicine

Pub Date : 2024-04-15 DOI: 10.1111/phpp.12964

Eman Mohamed Salah, Nermeen Ibrahim Bedair, Sarah Khalil Abd El‐Rahim, Mohammed Ahmed El‐Khalawany

IntroductionPityriasis lichenoides chronica is the chronic end of the spectrum of pityriasis lichenoides which have several forms of papulosuamous conditions. Several treatments obtained complete clearance of the condition including phototherapy and specifically narrow band ultraviolet B. The Excimer light 308 is a monochromatic light that acts within the ultraviolet B wavelength and used as a targeted phototherapy in several skin conditions.MethodsThirty‐four patients with histopathologically diagnosed pityriasis lichenoides chronica underwent treatment with biweekly sessions of excimer light 308 nm. Treatment continued until complete clearance was obtained or to a maximum of 48 sessions (24 weeks).ResultsThirty‐one patients obtained complete clearance with no recurrence till the end of the study period, two patients had partial response and only one patient showed poor response to treatment.ConclusionExcimer light can be a safe and effective treatment of pityriasis lichinoides chronica in different ages and genders.

导言：慢性斑丘疹性苔藓是斑丘疹性苔藓的慢性病，它有多种形式的丘疹脓疱病。准分子光 308 是一种单色光，其波长在紫外线 B 波段内，可用于多种皮肤病的靶向光疗。方法34 名经组织病理学诊断为慢性斑癣的患者每两周接受一次准分子光 308 nm 治疗。结果31名患者完全痊愈，直到研究结束也没有复发，2名患者有部分反应，只有1名患者对治疗反应不佳。

引用次数: 0

Report of a case with CARD14‐associated papulosquamous eruptions and multiple skin cancers 一例与 CARD14 相关的丘疹鳞状溃疡和多发性皮肤癌病例的报告

IF 2.6 4区医学 Q2 DERMATOLOGY

Photodermatology, photoimmunology & photomedicine

Pub Date : 2024-04-15 DOI: 10.1111/phpp.12969

Chia‐Jung Hsu, Tsen‐Fang Tsai

引用次数: 0

Effect of photodynamic therapy with 5-aminolevulinic acid and EDTA-2Na against mixed infection of methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa. 5-aminolevulinic acid 和 EDTA-2Na 光动力疗法对耐甲氧西林金黄色葡萄球菌和铜绿假单胞菌混合感染的影响。

IF 2.6 4区医学 Q2 DERMATOLOGY

Photodermatology, photoimmunology & photomedicine

Pub Date : 2024-03-01 DOI: 10.1111/phpp.12959

Rie Teranishi, Toshiyuki Ozawa, Bunpei Katayama, Yu Shimojo, Nobuhisa Ito, Kunio Awazu, Daisuke Tsuruta

Background: The increasing abundance of drug-resistant bacteria is a global threat. Photodynamic therapy is an entirely new, non-invasive method for treating infections caused by antibiotic-resistant strains. We previously described the bactericidal effect of photodynamic therapy on infections caused by a single type of bacterium. We showed that gram-positive and gram-negative bacteria could be killed with 5-aminolevulic acid and 410 nm light, respectively. However, clinically, mixed infections are common and difficult to treat.

Objective: We investigated the bactericidal effects of photodynamic therapy on mixed infections of methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa.

Methods: We compared bacterial growth with and without photodynamic therapy in vitro. Then, in vivo, we studied mixed infections in a mouse skin ulcer model. We evaluated the rates of ulcer area reduction and transitions to healing in treated and untreated mice. In addition, a comparison was made between PDT and existing topical drugs.

Results: We found that photodynamic therapy markedly reduced the growth of both methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa, in culture, and it reduced the skin ulcer areas in mice. PDT was also more effective than existing topical medicines.

Conclusion: This study showed that photodynamic therapy had antibacterial effects against a mixed infection of gram-positive and gram-negative bacteria, and it promoted skin ulcer healing. These results suggested that photodynamic therapy could be effective in both single- and mixed-bacterial infections.

背景：抗药性细菌日益增多是一个全球性威胁。光动力疗法是一种全新的非侵入性方法，可用于治疗由抗生素耐药菌株引起的感染。我们曾描述过光动力疗法对单一类型细菌引起的感染的杀菌效果。我们的研究表明，5-氨基乙酰乙酸和 410 纳米波长的光可分别杀死革兰氏阳性和革兰氏阴性细菌。然而，在临床上，混合感染很常见，而且难以治疗：我们研究了光动力疗法对耐甲氧西林金黄色葡萄球菌和铜绿假单胞菌混合感染的杀菌效果：方法：我们在体外比较了使用光动力疗法和未使用光动力疗法的细菌生长情况。然后，我们在小鼠皮肤溃疡模型中对体内混合感染进行了研究。我们评估了治疗和未治疗小鼠的溃疡面积缩小率和愈合率。此外，我们还将光动力疗法与现有的外用药物进行了比较：结果：我们发现光动力疗法明显减少了耐甲氧西林金黄色葡萄球菌和铜绿假单胞菌在培养基中的生长，并缩小了小鼠的皮肤溃疡面积。光动力疗法比现有的外用药物更有效：这项研究表明，光动力疗法对革兰氏阳性菌和革兰氏阴性菌混合感染有抗菌作用，并能促进皮肤溃疡愈合。这些结果表明，光动力疗法对单一细菌和混合细菌感染均有效。

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引用次数: 0

Efficacy of transcranial photobiomodulation in the treatment for major depressive disorder: A TMS-EEG and pilot study. 经颅光生物调制治疗重度抑郁症的疗效：TMS-EEG和试验研究。

IF 2.6 4区医学 Q2 DERMATOLOGY

Photodermatology, photoimmunology & photomedicine

Pub Date : 2024-03-01 DOI: 10.1111/phpp.12957

Wensi Hao, Xiaona Dai, Min Wei, Siran Li, Mao Peng, Qing Xue, Hua Lin, Huicong Wang, Penghui Song, Yuping Wang

Background: Major depressive disorder (MDD) was a prevalent mental condition that may be accompanied by decreased excitability of left frontal pole (FP) and abnormal brain connections. An 820 nm tPBM can induce an increase in stimulated cortical excitability. The purpose of our study was to establish how clinical symptoms and time-varying brain network connectivity of MDD were affected by transcranial photobiomodulation (tPBM).

Methods: A total of 11 patients with MDD received 820 nm tPBM targeting the left FP for 14 consecutive days. The severity of symptoms was evaluated by neuropsychological assessments at baseline, after treatment, 4-week and 8-week follow-up; 8-min transcranial magnetic stimulation combined electroencephalography (TMS-EEG) was performed for five healthy controls and five patients with MDD before and after treatment, and time-varying EEG network was analyzed using the adaptive-directed transfer function.

Results: All of scales scores in the 11 patients decreased significantly after 14-day tPBM (p < .01) and remained at 8-week follow-up. The time-varying brain network analysis suggested that the brain regions with enhanced connection information outflow in MDD became gradually more similar to healthy controls after treatment.

Conclusions: This study showed that tPBM of the left FP could improve symptoms of patients with MDD and normalize the abnormal network connections.

背景：重度抑郁症（MDD）是一种常见的精神疾病，可能伴有左额叶兴奋性降低和大脑连接异常。820 nm tPBM 可诱导刺激皮层兴奋性的增加。我们的研究旨在确定经颅光生物调控（tPBM）如何影响 MDD 的临床症状和时变脑网络连接：方法：共有11名多发性硬化症患者连续14天接受了以左侧FP为靶点的820纳米经颅光生物调控（tPBM）治疗。在基线、治疗后、4周和8周的随访中，通过神经心理学评估评估了症状的严重程度；在治疗前后，对5名健康对照组和5名MDD患者进行了8分钟经颅磁刺激联合脑电图（TMS-EEG）检查，并使用自适应定向传递函数分析了时变脑电网络：结果：经过 14 天的 tPBM 治疗后，11 名患者的所有量表评分均明显降低（p 结论：tPBM 对多发性硬化症患者的疗效显著：本研究表明，左侧 FP 的 tPBM 可以改善 MDD 患者的症状，并使异常网络连接正常化。

{"title":"Efficacy of transcranial photobiomodulation in the treatment for major depressive disorder: A TMS-EEG and pilot study.","authors":"Wensi Hao, Xiaona Dai, Min Wei, Siran Li, Mao Peng, Qing Xue, Hua Lin, Huicong Wang, Penghui Song, Yuping Wang","doi":"10.1111/phpp.12957","DOIUrl":"10.1111/phpp.12957","url":null,"abstract":"Background: Major depressive disorder (MDD) was a prevalent mental condition that may be accompanied by decreased excitability of left frontal pole (FP) and abnormal brain connections. An 820 nm tPBM can induce an increase in stimulated cortical excitability. The purpose of our study was to establish how clinical symptoms and time-varying brain network connectivity of MDD were affected by transcranial photobiomodulation (tPBM).Methods: A total of 11 patients with MDD received 820 nm tPBM targeting the left FP for 14 consecutive days. The severity of symptoms was evaluated by neuropsychological assessments at baseline, after treatment, 4-week and 8-week follow-up; 8-min transcranial magnetic stimulation combined electroencephalography (TMS-EEG) was performed for five healthy controls and five patients with MDD before and after treatment, and time-varying EEG network was analyzed using the adaptive-directed transfer function.Results: All of scales scores in the 11 patients decreased significantly after 14-day tPBM (p < .01) and remained at 8-week follow-up. The time-varying brain network analysis suggested that the brain regions with enhanced connection information outflow in MDD became gradually more similar to healthy controls after treatment.Conclusions: This study showed that tPBM of the left FP could improve symptoms of patients with MDD and normalize the abnormal network connections.","PeriodicalId":20123,"journal":{"name":"Photodermatology, photoimmunology & photomedicine","volume":"40 2","pages":"e12957"},"PeriodicalIF":2.6,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140102206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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