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Integrating Orthognathic Surgery Into Lip Lift for Subnasal Aesthetics. 将正颌手术与鼻下美容唇提术相结合。
IF 1.8 Q3 SURGERY Pub Date : 2025-12-09 eCollection Date: 2025-12-01 DOI: 10.1097/GOX.0000000000007230
Yoshitsugu Hattori, Hirokazu Uda, Makoto Omori, Takanobu Mashiko, Yasushi Sugawara

Lip lift is a versatile procedure to shorten the upper lip and improve the morphology and proportion of the lip. It is commonly performed as part of facial rejuvenation in Western patients, whereas in Asian countries, younger people tend to desire a lip lift because a shorter upper lip is considered more attractive. The lip lift carries a risk of an unfavorable aesthetic outcome when underlying skeletal deformities, such as maxillary protrusion and vertical excess, are not addressed, resulting in an undesirable degree of dental exposure. This article described our experience of integrating orthognathic surgery into subnasal lip lift surgery to harmonize the facial profile, highlighting the methods to achieve an ideal dental show with lip lift. Orthognathic surgery was first performed to correct the skeletal deformity. Subnasal lip lift with bull's horn-type skin excision and orbicularis oris muscle resection was then performed as a staged procedure. The degree of Cupid's bow elevation was determined by the amount of skin excised, and incisor show was determined by the amount of muscle resected. Seventeen patients underwent this combination approach, and the upper lip was successfully shortened with appropriate proportions and dental show. Overall, the aesthetic results were pleasing, with high patient satisfaction. Integrating orthognathic surgery into a lip lift aids in the enhancement of perioral aesthetics. Preexisting skeletal deformities need to be diagnosed before the lip lift and should be corrected when indicated.

拉唇是一种通用的程序,缩短上唇,改善唇的形态和比例。在西方患者中,这通常是面部年轻化的一部分,而在亚洲国家,年轻人往往希望做唇提术,因为上唇较短被认为更有吸引力。当潜在的骨骼畸形,如上颌突出和垂直过度,没有得到解决,导致牙齿暴露的不良程度时,唇提术会带来不利的美学结果的风险。本文介绍了我们将正颌手术与鼻下拉唇手术相结合的经验,以协调面部轮廓,重点介绍了通过拉唇手术达到理想的牙齿外观的方法。正颌手术首先用于矫正骨骼畸形。然后分阶段进行鼻下唇提升、牛角型皮肤切除和口轮匝肌切除。丘比特弓抬高的程度由切除的皮肤数量决定,切牙的显示程度由切除的肌肉数量决定。17例患者采用此联合入路,均成功缩短上唇,比例合适,牙形美观。总体而言,美观效果令人满意,患者满意度高。将正颌手术纳入唇提术有助于提高口腔周围的美观。先前存在的骨骼畸形需要在提唇前确诊,并在需要时予以纠正。
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引用次数: 0
Source-grounded Artificial Intelligence-Driven Transfer of Plastic Surgery Textbooks to Podcasts: Creation of Content and Trainee Satisfaction. 基于源的人工智能驱动的整形外科教科书到播客的转移:内容和学员满意度的创造。
IF 1.8 Q3 SURGERY Pub Date : 2025-12-09 eCollection Date: 2025-12-01 DOI: 10.1097/GOX.0000000000007299
Iulianna Taritsa, Parul Rai, Anitesh Bajaj, Hannah Soltani, Arun K Gosain

Source-grounded artificial intelligence (AI) models have emerged in the public domain and represent a powerful tool for content creation. These models allow users to "ground" the language model in user-input sources and convert text to audio. Although plastic and reconstructive surgery has traditionally relied on textbook sources for trainee education, we demonstrate the potential to migrate information to audio sources. We created podcasts using source-grounded AI technology based on selected chapters of Grabb and Smith's Plastic Surgery. Generated audio was created using NotebookLM and featured a conversation between 2 AI "broadcasters." Surveys were distributed to assess trainee feedback on AI-generated podcasts compared with the source material. Eight source-grounded AI podcasts were created on topics including wound healing, breast reconstruction, lower extremity reconstruction, and aesthetic principles. Generated audio had a mean length of 14.3 ± 0.2 minutes. Generated podcasts had excellent accuracy with no extraneous insertion of information. Weaknesses of AI-generated podcasts included under- or overemphasis on topics that were emphasized in the source. Survey participants (n = 10) on average spent 14.7 ± 4.7 minutes with the podcast and 34.0 ± 13.9 minutes with the book chapter. Participants preferred a mixed-media approach (90%) over text (0%) or audio alone (10%) for learning the specified material. We demonstrate the potential for source-grounded AI models to aid in the creation of audio-based plastic surgery educational content with high accuracy. This technology can translate plastic surgery literature into audible content to diversify the media available to trainees and practitioners.

基于源的人工智能(AI)模型已经出现在公共领域,并代表了内容创作的强大工具。这些模型允许用户在用户输入源中“接地”语言模型,并将文本转换为音频。尽管整形和重建手术传统上依赖于教科书来源的培训生教育,但我们证明了将信息迁移到音频来源的潜力。我们根据《Grabb and Smith’s Plastic Surgery》的部分章节,使用人工智能技术创建了播客。生成的音频是使用NotebookLM创建的,并以两个AI“播音员”之间的对话为特色。分发了调查问卷,以评估实习生对人工智能生成的播客的反馈,并将其与原始材料进行比较。8个人工智能播客的主题包括伤口愈合、乳房重建、下肢重建和美学原则。生成的音频平均长度为14.3±0.2分钟。生成的播客具有极好的准确性,没有多余的信息插入。人工智能生成的播客的缺点包括对源中强调的主题的强调不足或过度强调。调查参与者(n = 10)平均花14.7±4.7分钟在播客上,34.0±13.9分钟在书本章节上。在学习指定材料时,参与者更喜欢混合媒体方法(90%),而不是文本(0%)或单独的音频(10%)。我们展示了基于源的人工智能模型的潜力,以帮助以高精度创建基于音频的整形外科教育内容。这项技术可以将整形外科文献翻译成可听的内容,使受训者和从业者可以使用的媒体多样化。
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引用次数: 0
Validation of a Machine Learning Model for Predicting Postmastectomy Radiotherapy Recommendation Following Immediate Breast Reconstruction. 预测乳房切除术后放疗建议的机器学习模型的验证。
IF 1.8 Q3 SURGERY Pub Date : 2025-12-09 eCollection Date: 2025-12-01 DOI: 10.1097/GOX.0000000000007311
Jaimie J Lee, Yi-Fu Chen, Gregory Arbour, Alan M Nichol, Raymond T Ng, Kathryn V Isaac

Background: Postmastectomy radiotherapy (PMRT) in the context of immediate implant-based breast reconstruction (IIBBR) is associated with long-term morbidity. The likelihood of PMRT may influence the type and timing of breast reconstruction chosen in the preoperative setting. This study aimed to validate a machine learning (ML) model for predicting the probability of PMRT recommendations in IIBBR patients, in accordance with the transparent reporting of studies on prediction models for individual prognosis or diagnosis guidelines.

Methods: The study cohort comprised 224 breast cancer patients who underwent mastectomy with IIBBR from January 2021 to December 2022. Data were collected on 12 patient characteristics identified as predictive in our ML model. Preoperative characteristics were recorded from clinical history, physical examination, diagnostic imaging, and pathology reports.

Results: Of the 224 patients, 37% (n = 84) were recommended PMRT. Our ML model demonstrated high predictive performance, with an area under the receiver operating characteristic curve score of 0.80 (0.74-0.86). The variables most predictive of PMRT recommendation included the size of suspicious lymph nodes, the presence of carcinoma in axillary lymph node biopsies, tumor size, and the use of ultrasound as the initial diagnostic modality.

Conclusions: An ML model for predicting PMRT recommendations following IIBBR was validated. This prediction model may be helpful in the preoperative clinical setting to inform the discussion of reconstructive options.

背景:乳房切除术后放疗(PMRT)在立即植入式乳房重建(IIBBR)的背景下与长期发病率相关。PMRT的可能性可能影响术前选择乳房重建的类型和时间。本研究旨在根据个体预后或诊断指南预测模型研究的透明报告,验证用于预测IIBBR患者PMRT推荐概率的机器学习(ML)模型。方法:研究队列包括224名于2021年1月至2022年12月接受IIBBR乳房切除术的乳腺癌患者。收集了在我们的ML模型中确定为预测性的12个患者特征的数据。术前记录临床病史、体格检查、诊断影像和病理报告。结果:224例患者中,37% (n = 84)推荐PMRT。我们的ML模型表现出很高的预测性能,在接收者工作特征曲线下的面积得分为0.80(0.74-0.86)。最能预测PMRT推荐的变量包括可疑淋巴结的大小,腋窝淋巴结活检中癌的存在,肿瘤大小,以及超声作为初始诊断方式的使用。结论:预测IIBBR后PMRT建议的ML模型得到了验证。该预测模型可能有助于术前临床设置,告知重建方案的讨论。
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引用次数: 0
Microsurgical Breast Reconstruction Options After Abdominoplasty: Lumbar Artery Perforator Versus Profunda Artery Perforator. 腹部成形术后显微外科乳房重建选择:腰动脉穿通器与深动脉穿通器。
IF 1.8 Q3 SURGERY Pub Date : 2025-12-09 eCollection Date: 2025-12-01 DOI: 10.1097/GOX.0000000000007332
Sumeet S Teotia, Thomas C Troia, Lauren J Kim, Nicholas T Haddock

Background: Patients who have undergone abdominoplasty face limited options for microsurgical breast reconstruction, as the deep inferior epigastric perforator flap is often unavailable. This study compared lumbar artery perforator (LAP) and profunda artery perforator (PAP) flaps for microsurgical breast reconstruction in patients with prior abdominoplasty.

Methods: A retrospective chart review was conducted on all patients who underwent microsurgical breast reconstruction between January 2011 and May 2023. Data analyzed included demographics, comorbidities, reconstruction type, complications, and patient-reported outcomes measured by BREAST-Q surveys. Statistical analysis used the Pearson χ2 test and independent samples t test.

Results: A total of 264 patients underwent microsurgical breast reconstruction, with 39 having a history of abdominoplasty. Patients with prior abdominoplasty were older (54.4 ± 7.8 versus 50.5 ± 9.1 y, P = 0.012) and had a significantly higher body mass index (28.8 ± 4.4 versus 25.3 ± 4.2 kg/m2, P < 0.001). Hypertension (30.8% versus 15.6%, P = 0.023) and diabetes (12.8% versus 4.0%, P = 0.024) were also more common in the abdominoplasty group. Among abdominoplasty patients, LAP flaps were more often undergone (66.7% versus 26.2%, P < 0.001). LAP flap recipients reported significantly higher BREAST-Q scores compared with PAP flap patients (all P < 0.001).

Conclusions: The LAP flap emerges as a superior option for microsurgical breast reconstruction in patients with prior abdominoplasty, providing higher patient satisfaction compared with PAP flaps. This study highlights the necessity of personalized, adaptable surgical approaches in microsurgical breast reconstruction, emphasizing patient-specific anatomical and historical considerations to optimize outcomes.

背景:接受过腹部成形术的患者面临显微外科乳房重建的选择有限,因为深下腹部穿支皮瓣通常不可用。本研究比较了腰动脉穿支皮瓣(LAP)和深动脉穿支皮瓣(PAP)在既往腹部成形术患者显微外科乳房重建中的应用。方法:对2011年1月至2023年5月间所有行显微外科乳房重建的患者进行回顾性图表分析。分析的数据包括人口统计学、合并症、重建类型、并发症和通过BREAST-Q调查测量的患者报告的结果。统计学分析采用Pearson χ2检验和独立样本t检验。结果:264例患者行显微外科乳房重建术,其中39例有腹部成形术史。先前腹部成形术的患者年龄较大(54.4±7.8比50.5±9.1,P = 0.012),体重指数明显较高(28.8±4.4比25.3±4.2 kg/m2, P < 0.001)。高血压(30.8%比15.6%,P = 0.023)和糖尿病(12.8%比4.0%,P = 0.024)在腹部成形术组中也更为常见。在腹部成形术患者中,LAP皮瓣更常见(66.7%比26.2%,P < 0.001)。LAP瓣接受者报告的BREAST-Q评分明显高于PAP瓣患者(均P < 0.001)。结论:与PAP皮瓣相比,LAP皮瓣是既往腹部成形术患者显微外科乳房重建的首选,患者满意度更高。本研究强调了在显微外科乳房重建中采用个性化、适应性强的手术方法的必要性,强调了患者特定的解剖学和历史因素,以优化结果。
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引用次数: 0
Patient-reported Outcome Measures in Head and Neck Reconstruction: A Systematic Review Across Disciplines and Geographical Locations. 患者报告的头颈部重建的结果测量:跨学科和地理位置的系统回顾。
IF 1.8 Q3 SURGERY Pub Date : 2025-12-09 eCollection Date: 2025-12-01 DOI: 10.1097/GOX.0000000000007293
Pablo Pfister, Julia Stoffel, Marie Perrin, Christian Appenzeller-Herzog, Florian S Halbeisen, Lukas Seifert, Daniel Bodmer, Laurent Muller, Maximilian Burger, Rene D Largo, Tarek Ismail, Elisabeth A Kappos

Background: Patient-reported outcome measures (PROMs) have become an integral part of outcome evaluation in reconstructive microsurgery. This study explored the usage of PROMs in microsurgical oncological head and neck reconstruction across surgical specialties and geographic regions.

Methods: A systematic literature search was conducted in Embase, MEDLINE, and Web of Science to identify studies reporting on adult patients undergoing oncological head and neck free flap reconstruction. Data extracted included PROM tools used, study demographics, surgical disciplines involved, procedural details, and outcomes.

Results: Of 5015 screened studies, 354 (n = 30,369 patients) met the inclusion criteria. A total of 94 PROM tools were identified. The most frequently used were the University of Washington Quality of Life Questionnaire (34.75%), nonvalidated tools (25.99%), and the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire - Head and Neck Module 35 (22.32%). Donor site-specific PROMs were infrequently used (22%), though more frequently used when plastic and reconstructive surgeons were involved (31.11% versus 15.53%, P = 0.019). PROM selection varied significantly by specialty and geographic location, and only 20% of studies were interdisciplinary.

Conclusions: Substantial heterogeneity exists in the use of PROMs in head and neck reconstruction, with variations driven by specialty and region. This lack of standardization hinders meaningful cross-study comparisons and the development of robust quality benchmarks. A unified, validated PROM framework is urgently needed to support international evidence-based practice. Future efforts should prioritize interdisciplinary collaboration and incorporate donor-site evaluation to comprehensively assess outcomes in oncological head and neck reconstruction.

背景:患者报告的结果测量(PROMs)已成为重建显微手术结果评估的一个组成部分。本研究探讨了PROMs在显微外科肿瘤头颈部重建中的应用,跨越外科专业和地理区域。方法:系统检索Embase、MEDLINE和Web of Science中有关成人肿瘤头颈部游离皮瓣重建的文献。提取的数据包括使用的PROM工具、研究人口统计学、涉及的手术学科、手术细节和结果。结果:在5015项筛选研究中,354例(n = 30,369例)符合纳入标准。总共确定了94种PROM工具。最常用的是华盛顿大学生活质量问卷(34.75%),未经验证的工具(25.99%)和欧洲癌症研究和治疗组织生活质量问卷-头颈模块35(22.32%)。供体部位特异性PROMs很少使用(22%),但在涉及整形和重建手术时使用频率更高(31.11%对15.53%,P = 0.019)。毕业舞会的选择因专业和地理位置的不同而有很大差异,只有20%的研究是跨学科的。结论:PROMs在头颈部重建中的应用存在很大的异质性,其差异受专业和地区的驱动。这种标准化的缺乏阻碍了有意义的交叉研究比较和健全的质量基准的发展。迫切需要一个统一的、经过验证的PROM框架来支持国际循证实践。未来的努力应优先考虑跨学科合作,并纳入供体-部位评估,以全面评估肿瘤头颈部重建的结果。
{"title":"Patient-reported Outcome Measures in Head and Neck Reconstruction: A Systematic Review Across Disciplines and Geographical Locations.","authors":"Pablo Pfister, Julia Stoffel, Marie Perrin, Christian Appenzeller-Herzog, Florian S Halbeisen, Lukas Seifert, Daniel Bodmer, Laurent Muller, Maximilian Burger, Rene D Largo, Tarek Ismail, Elisabeth A Kappos","doi":"10.1097/GOX.0000000000007293","DOIUrl":"10.1097/GOX.0000000000007293","url":null,"abstract":"<p><strong>Background: </strong>Patient-reported outcome measures (PROMs) have become an integral part of outcome evaluation in reconstructive microsurgery. This study explored the usage of PROMs in microsurgical oncological head and neck reconstruction across surgical specialties and geographic regions.</p><p><strong>Methods: </strong>A systematic literature search was conducted in Embase, MEDLINE, and Web of Science to identify studies reporting on adult patients undergoing oncological head and neck free flap reconstruction. Data extracted included PROM tools used, study demographics, surgical disciplines involved, procedural details, and outcomes.</p><p><strong>Results: </strong>Of 5015 screened studies, 354 (n = 30,369 patients) met the inclusion criteria. A total of 94 PROM tools were identified. The most frequently used were the University of Washington Quality of Life Questionnaire (34.75%), nonvalidated tools (25.99%), and the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire - Head and Neck Module 35 (22.32%). Donor site-specific PROMs were infrequently used (22%), though more frequently used when plastic and reconstructive surgeons were involved (31.11% versus 15.53%, <i>P</i> = 0.019). PROM selection varied significantly by specialty and geographic location, and only 20% of studies were interdisciplinary.</p><p><strong>Conclusions: </strong>Substantial heterogeneity exists in the use of PROMs in head and neck reconstruction, with variations driven by specialty and region. This lack of standardization hinders meaningful cross-study comparisons and the development of robust quality benchmarks. A unified, validated PROM framework is urgently needed to support international evidence-based practice. Future efforts should prioritize interdisciplinary collaboration and incorporate donor-site evaluation to comprehensively assess outcomes in oncological head and neck reconstruction.</p>","PeriodicalId":20149,"journal":{"name":"Plastic and Reconstructive Surgery Global Open","volume":"13 12","pages":"e7293"},"PeriodicalIF":1.8,"publicationDate":"2025-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12688922/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145725020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Coronavirus Disease 2019 Pandemic on Delivery of Breast Reconstructive Services and Outcomes. 2019冠状病毒病大流行对乳房再造服务提供及结果的影响
IF 1.8 Q3 SURGERY Pub Date : 2025-12-09 eCollection Date: 2025-12-01 DOI: 10.1097/GOX.0000000000007331
Christy O T Kwok, Shreya Luthra, Kimberly DeVries, Esta Bovill, Nancy Yvonne Van Laeken, Sheina Macadam, Peter Lennox, Christopher Doherty, Kathryn V Isaac

Background: Delivery of immediate breast reconstruction (IBR) was severely restricted during the coronavirus disease 2019 (COVID-19) pandemic, with irreversible consequences for breast cancer survivors. This study aimed to determine the pandemic's effect on the provision of IBR services, quality of care delivered, and reconstructive outcomes.

Methods: For this multi-institutional, retrospective cohort study, data were obtained from all IBR cases during the study periods defined as "pre-COVID-19" (October 1, 2018, to March 14, 2020) and "COVID-19" (March 15, 2020, to October 31, 2021). Patient demographics, reconstructive strategy types, and oncological and surgical characteristics were analyzed. Safety and quality outcomes, including readmission, infection, seroma, mastectomy flap necrosis, and wait times were recorded.

Results: A cohort of 525 patients was included in this study. Patient and tumor characteristics were similar between the 2 study periods. There was a significantly lower odds of undergoing a single-stage alloplastic surgery (odds ratio [OR] = 0.40, 95% confidence interval [CI] = 0.17-0.94, P = 0.0365) or autologous immediate reconstruction with a deep inferior epigastric perforator (DIEP) flap (OR = 0.42, 95% CI = 0.21-0.85, P = 0.015) during the COVID-19 era, with a reciprocal 53% higher odds of 2-stage alloplastic surgery (OR = 1.53, 95% CI = 1.03-2.27, P = 0.0359) during that time. Median wait time from first-stage to second-stage reconstruction was significantly shorter during COVID-19 (P = 0.0017). There were no differences in safety outcomes between the periods.

Conclusions: Reconstructive strategies differed during the COVID-19 era of resource limitations with more 2-stage alloplastic procedures and fewer single-stage alloplastic and autologous immediate DIEP flap procedures.

背景:在2019冠状病毒病(COVID-19)大流行期间,立即乳房重建(IBR)的实施受到严重限制,对乳腺癌幸存者造成了不可逆转的后果。本研究旨在确定大流行对IBR服务的提供、提供的护理质量和重建结果的影响。方法:在这项多机构、回顾性队列研究中,数据来自研究期间的所有IBR病例,研究期间定义为“COVID-19前期”(2018年10月1日至2020年3月14日)和“COVID-19”(2020年3月15日至2021年10月31日)。分析患者人口统计学、重建策略类型、肿瘤和外科特征。记录安全性和质量结果,包括再入院、感染、血清肿、乳房切除术皮瓣坏死和等待时间。结果:本研究纳入了525例患者。两个研究期间患者及肿瘤特征相似。在COVID-19时期,接受单期同种异体整形手术的几率(比值比[OR] = 0.40, 95%可信区间[CI] = 0.17-0.94, P = 0.0365)或采用上腹部深下穿支(DIEP)皮瓣进行自体立即重建的几率(OR = 0.42, 95% CI = 0.21-0.85, P = 0.015)显著降低,而接受两期同种异体整形手术的几率(OR = 1.53, 95% CI = 1.03-2.27, P = 0.0359)的几率则高出53%。COVID-19患者从第一阶段到第二阶段重建的中位等待时间显著缩短(P = 0.0017)。两个时期的安全性结果没有差异。结论:在资源有限的COVID-19时代,重建策略不同,更多的是2期同种异体移植手术,更少的是单期同种异体移植和自体立即DIEP皮瓣手术。
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引用次数: 0
Ethosome (ETHOSOMEPTT) Photothermal Therapy with Nd:YAG Laser (Pastelle Pro): A Novel Nanotechnology Approach for Treatment-resistant Melasma. 用Nd:YAG激光(Pastelle Pro)光热治疗乙醇体(ETHOSOMEPTT):一种治疗耐药黄褐斑的新纳米技术方法。
IF 1.8 Q3 SURGERY Pub Date : 2025-12-09 eCollection Date: 2025-12-01 DOI: 10.1097/GOX.0000000000007318
Jee Soo Kook, Jovian Wan, Kyung Tae Bae, Kyu-Ho Yi

Melasma poses considerable challenges in dermatologic management, particularly due to variable treatment responses and frequent recurrence following conventional interventions. We describe ethosome photothermal therapy (ETHOSOMEPTT, N-Finders Co., Ltd, Korea), an innovative 5-layer nanosystem that integrates transdermal delivery technology with targeted laser energy. The platform incorporates ethosomes, phospholipid vesicles containing ethanol, with plasmonic gold and platinum nanoparticles to provide dual therapeutic mechanisms: enhanced drug penetration and controlled hyperthermia. Upon activation by specific laser wavelengths, this system generates localized heat while facilitating the delivery of active ingredients to deeper tissue layers relative to conventional topical treatments. A clinical example demonstrates its utility: a 42-year-old woman with persistent malar melasma spanning 6 years, who had undergone treatment with hydroquinone, oral tranexamic acid, and neodymium-doped yttrium aluminum garnet laser with insufficient improvement, demonstrated a 68% reduction in Modified Melasma Area and Severity Index after 12 treatment sessions. Treatment was well tolerated, with transient erythema as the primary side effect. The mechanism underlying ethosome photothermal therapy encompasses ethanol-mediated enhancement of stratum corneum permeability, targeted delivery via plasmonic nanoparticles, and controlled thermal effects on tissue structure. This methodology represents a potential advancement in melasma management, particularly for cases demonstrating limited response to conventional therapies.

黄褐斑在皮肤科管理中提出了相当大的挑战,特别是由于传统干预措施后治疗反应不一和频繁复发。我们描述了ethos光热疗法(ETHOSOMEPTT, N-Finders Co., Ltd, Korea),这是一种创新的5层纳米系统,将透皮输送技术与靶向激光能量相结合。该平台将溶酶体(含乙醇的磷脂囊泡)与等离子体金和铂纳米粒子结合在一起,提供双重治疗机制:增强药物渗透和控制热疗。在特定激光波长的激活下,该系统产生局部热量,同时与传统的局部治疗相比,有助于将活性成分输送到更深的组织层。一个临床案例证明了它的实用性:一名42岁的女性患有持续6年的恶性黄褐斑,她接受了对苯二酚、口服氨甲环酸和掺钕钇铝石榴石激光治疗,但改善不足,在12次治疗后,改良黄褐斑面积和严重程度指数减少了68%。治疗耐受性良好,主要副作用为短暂性红斑。乙醇体光热疗法的机制包括乙醇介导的角质层通透性增强,等离子体纳米粒子靶向递送,以及对组织结构的控制热效应。这种方法代表了黄褐斑管理的潜在进步,特别是对于对传统疗法反应有限的病例。
{"title":"Ethosome (ETHOSOMEPTT) Photothermal Therapy with Nd:YAG Laser (Pastelle Pro): A Novel Nanotechnology Approach for Treatment-resistant Melasma.","authors":"Jee Soo Kook, Jovian Wan, Kyung Tae Bae, Kyu-Ho Yi","doi":"10.1097/GOX.0000000000007318","DOIUrl":"10.1097/GOX.0000000000007318","url":null,"abstract":"<p><p>Melasma poses considerable challenges in dermatologic management, particularly due to variable treatment responses and frequent recurrence following conventional interventions. We describe ethosome photothermal therapy (ETHOSOMEPTT, N-Finders Co., Ltd, Korea), an innovative 5-layer nanosystem that integrates transdermal delivery technology with targeted laser energy. The platform incorporates ethosomes, phospholipid vesicles containing ethanol, with plasmonic gold and platinum nanoparticles to provide dual therapeutic mechanisms: enhanced drug penetration and controlled hyperthermia. Upon activation by specific laser wavelengths, this system generates localized heat while facilitating the delivery of active ingredients to deeper tissue layers relative to conventional topical treatments. A clinical example demonstrates its utility: a 42-year-old woman with persistent malar melasma spanning 6 years, who had undergone treatment with hydroquinone, oral tranexamic acid, and neodymium-doped yttrium aluminum garnet laser with insufficient improvement, demonstrated a 68% reduction in Modified Melasma Area and Severity Index after 12 treatment sessions. Treatment was well tolerated, with transient erythema as the primary side effect. The mechanism underlying ethosome photothermal therapy encompasses ethanol-mediated enhancement of stratum corneum permeability, targeted delivery via plasmonic nanoparticles, and controlled thermal effects on tissue structure. This methodology represents a potential advancement in melasma management, particularly for cases demonstrating limited response to conventional therapies.</p>","PeriodicalId":20149,"journal":{"name":"Plastic and Reconstructive Surgery Global Open","volume":"13 12","pages":"e7318"},"PeriodicalIF":1.8,"publicationDate":"2025-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12688895/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145724654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Innovative Preoperative Mathematical Suggestion for Vertical Incision in Mammaplasty. 乳房成形术中垂直切口的创新术前数学建议。
IF 1.8 Q3 SURGERY Pub Date : 2025-12-09 eCollection Date: 2025-12-01 DOI: 10.1097/GOX.0000000000007323
Mohammadhossein Hesamirostami, Sami Hesamirostami, Sanli Hesamirostami

One of the most important and challenging decisions in reduction mammaplasty and mastopexy is the choice of incision. Although an existing algorithm considers the sternal notch-nipple distance, patient age, and skin quality to guide selection, it remains incomplete. The superior breast border-inframammary fold distance provides a more accurate assessment of the actual amount of skin and tissue. By analyzing this measurement-along with its components and the patient's skin quality-we can determine the optimal incision type using the mathematics of distances and breast geometry. In brief, a superior breast border-inframammary fold distance of up to approximately 32 cm is generally suitable for a vertical scar mammaplasty.

乳房缩小成形术和乳房切除术中最重要和最具挑战性的决定之一是切口的选择。虽然现有的算法考虑胸骨缺口-乳头距离、患者年龄和皮肤质量来指导选择,但它仍然不完整。乳房边缘-乳腺下褶距离较近,能更准确地评估皮肤和组织的实际数量。通过分析这一测量结果——以及它的组成部分和病人的皮肤质量——我们可以利用距离和乳房几何的数学计算来确定最佳的切口类型。简而言之,纵向疤痕乳房成形术通常适用于乳房边缘-乳房下褶皱距离约为32厘米的乳房。
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引用次数: 0
Comparing Predictors for Leadership in Surgical Subspecialty National Organizations. 比较外科亚专科国家组织领导能力的预测因素。
IF 1.8 Q3 SURGERY Pub Date : 2025-12-08 eCollection Date: 2025-12-01 DOI: 10.1097/GOX.0000000000007330
Jason Zhang, Narainsai K Reddy, Gabrielle C Rodriguez, Kristian Nenchev, Nikhil Sriram, Morgan Gamble, Muhammad T Hassan, Reyna A Patel, Parul Rai, Hannah Soltani, Arun K Gosain

Background: Analyzing characteristics of national leaders in surgery can provide insight into the factors that contribute to their success.

Methods: The names of the 2024 executive board and past presidents were collected from national surgical subspecialty organizations. A cross-sectional analysis of training and leadership backgrounds was conducted from information gathered online. Logistic regression was used to analyze predictors for executive positions.

Results: A total of 871 leaders from 48 organizations were characterized, including 66 plastic surgeons. Most (84.5%) leaders completed a subspecialty-specific fellowship and had a mean of 3.6 institutional positions. The number of chief/chair positions (odds ratio [95% confidence interval] = 1.55 [1.31-1.84]) and editor positions (1.11 [1.02-1.23]) were associated with increased odds of being a national vice president/president, whereas completing multiple fellowships was associated with decreased odds (odds ratio [95% confidence interval] = 0.56 [0.35-0.88]). Plastic surgery leaders had higher rates of no fellowship training (22.7% versus 5.5%) and a lower average number of industry positions (0.1 versus 0.4) compared with those in other fields. Compared with presidents in other specialties, plastic surgery presidents had lower rates of subspecialty-specific fellowship training (72.2% versus 84.9%).

Conclusions: Experience leading at the institutional level is correlated with national surgical leadership. Our findings may help guide young plastic surgeons hoping to become involved at the national level.

背景:分析国家外科领导者的特点,有助于深入了解他们成功的因素。方法:收集全国外科亚专科组织2024届执行理事及历届会长名单。从网上收集的信息对培训和领导背景进行了横断面分析。运用逻辑回归分析行政职位的预测因子。结果:对48家机构的871名领导进行了分析,其中66名是整形外科医生。大多数(84.5%)领导者完成了亚专业特定的奖学金,平均拥有3.6个机构职位。首席/主席职位(优势比[95%置信区间]= 1.55[1.31-1.84])和编辑职位(优势比[1.11[1.02-1.23])的数量与成为国家副总统/主席的几率增加相关,而完成多个奖学金的几率降低相关(优势比[95%置信区间]= 0.56[0.35-0.88])。与其他行业相比,整形外科的负责人没有接受过培训的比率(22.7%比5.5%)较高,而平均行业职位数(0.1比0.4)较低。与其他专科的院长相比,整形外科院长接受亚专科奖学金培训的比例较低(72.2%对84.9%)。结论:机构层面的经验领导与国家外科领导相关。我们的发现可能有助于指导年轻的整形外科医生希望参与到国家层面。
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引用次数: 0
Temporary Tattoo Application Developed Based on 3-dimensional Design in Marking of Breast Reduction/Lift Surgery. 基于三维设计的临时纹身应用于缩胸/提胸手术标记。
IF 1.8 Q3 SURGERY Pub Date : 2025-12-08 eCollection Date: 2025-12-01 DOI: 10.1097/GOX.0000000000007346
Mustafa Tezcan

Preoperative markings are essential in breast reduction surgery, yet conventional hand-drawn methods may be prone to inaccuracies, particularly in patients with large or ptotic breasts. This study aimed to introduce and evaluate a standardized preoperative drawing method using temporary tattoos based on 3-dimensional (3D) breast modeling. Three-dimensional breast models were created using Blender 3D software, incorporating various base diameters and nipple-areola complex widths. The models were flattened into 2D templates and transferred to skin using temporary tattoos. A 5-step standardized drawing protocol was designed and applied to the simulated model. Ratios between breast base circumference and nipple-areola complex diameter were analyzed to guide excision planning. The 2D templates preserved key proportional relationships derived from 3D analysis. The use of temporary tattoos reduced variability in markings caused by tissue elasticity and human error. Tattoos remained intact for several days, enabling surgeons to perform and verify markings ahead of surgery without disruption to daily activities. Temporary tattoos based on 3D modeling offer a reproducible, patient-friendly, and easy guide for preoperative planning in breast reduction surgery. This method may enhance surgical precision and improve aesthetic outcomes.

术前标记在乳房缩小手术中是必不可少的,然而传统的手绘方法可能容易不准确,特别是对于大乳房或下垂的患者。本研究旨在介绍和评估一种基于三维乳房建模的标准化术前绘制方法——临时纹身。使用Blender 3D软件创建三维乳房模型,结合各种基底直径和乳头-乳晕复合宽度。这些模型被压成二维模板,然后用临时纹身转移到皮肤上。设计了5步标准化绘图方案,并将其应用于仿真模型。分析乳房基底周长与乳头乳晕复合直径的比值,以指导切除计划。2D模板保留了从3D分析中得出的关键比例关系。临时纹身的使用减少了由组织弹性和人为错误引起的标记变化。纹身可以完好无损地保存几天,这使得外科医生在手术前进行手术并验证标记,而不会影响日常活动。基于3D建模的临时纹身为缩胸手术的术前计划提供了一个可复制的、对患者友好的、简单的指导。该方法可提高手术精度,改善美观效果。
{"title":"Temporary Tattoo Application Developed Based on 3-dimensional Design in Marking of Breast Reduction/Lift Surgery.","authors":"Mustafa Tezcan","doi":"10.1097/GOX.0000000000007346","DOIUrl":"10.1097/GOX.0000000000007346","url":null,"abstract":"<p><p>Preoperative markings are essential in breast reduction surgery, yet conventional hand-drawn methods may be prone to inaccuracies, particularly in patients with large or ptotic breasts. This study aimed to introduce and evaluate a standardized preoperative drawing method using temporary tattoos based on 3-dimensional (3D) breast modeling. Three-dimensional breast models were created using Blender 3D software, incorporating various base diameters and nipple-areola complex widths. The models were flattened into 2D templates and transferred to skin using temporary tattoos. A 5-step standardized drawing protocol was designed and applied to the simulated model. Ratios between breast base circumference and nipple-areola complex diameter were analyzed to guide excision planning. The 2D templates preserved key proportional relationships derived from 3D analysis. The use of temporary tattoos reduced variability in markings caused by tissue elasticity and human error. Tattoos remained intact for several days, enabling surgeons to perform and verify markings ahead of surgery without disruption to daily activities. Temporary tattoos based on 3D modeling offer a reproducible, patient-friendly, and easy guide for preoperative planning in breast reduction surgery. This method may enhance surgical precision and improve aesthetic outcomes.</p>","PeriodicalId":20149,"journal":{"name":"Plastic and Reconstructive Surgery Global Open","volume":"13 12","pages":"e7346"},"PeriodicalIF":1.8,"publicationDate":"2025-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12685393/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145715376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Plastic and Reconstructive Surgery Global Open
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