Pub Date : 2026-01-09eCollection Date: 2026-01-01DOI: 10.1097/GOX.0000000000007375
Gabriel De La Cruz Ku, Jessica J Farzan, Jiddu Antonio Guart, Anshumi Desai, Camila Franco, Jessica Mroueh, Vanessa Mroueh, Camille Briskin, Nichita Kulkarni, Otto Ziegler Rodriguez, Gonzalo Ziegler Rodriguez
Background: Surgical intervention, particularly sentinel lymph node and lymph node dissection, is essential in managing melanoma, targeting locoregional disease. Our aim was to elucidate risk factors for postoperative lymphatic complications in melanoma patients undergoing lymph node surgery in Peru.
Methods: A retrospective cohort study was conducted, reviewing records of melanoma patients who underwent lymphatic surgery at the Instituto Nacional de Enfermedades Neoplásicas from 2010 to 2019. Descriptive statistics and logistic regression analyses were performed to identify predictors of lymphatic complications.
Results: The study included 699 melanoma patients (mean age 60.70 y, 51.4% women). Most patients were Hispanic (99.3%) and from Lima (52.8%), with lower extremity involvement being common. Surgical interventions included wide local excision (56.9%), sentinel lymph node surgery (67%), and lymph node dissection (32.3%). Complications at the site of lymph node dissection included wound dehiscence (1.6%), infection (6.2%), lymphoceles (5.7%), and lymphedema (2.7%). Multivariate analysis identified lymphatic invasion (odds ratio [OR] = 2.601, 95% confidence interval [CI]: 1.232-5.491) and positive lymph node pathology (OR = 2.066, 95% CI: 1.034-4.127) as risk factors, whereas primary lesion location in the upper extremity (OR = 0.055, 95% CI: 0.007-0.408) and trunk (OR = 0.106, 95% CI: 0.014-0.818) were protective factors.
Conclusions: Key risk factors for postoperative lymphatic complications in melanoma patients undergoing lymph node surgery include lower extremity involvement, lymph node dissections, lymphatic invasion, and positive lymph nodes. Understanding these risk factors can help clinicians optimize management strategies to reduce postoperative lymphatic complications.
{"title":"Lymphatic Complications in Patients Undergoing Melanoma Surgery in Peru.","authors":"Gabriel De La Cruz Ku, Jessica J Farzan, Jiddu Antonio Guart, Anshumi Desai, Camila Franco, Jessica Mroueh, Vanessa Mroueh, Camille Briskin, Nichita Kulkarni, Otto Ziegler Rodriguez, Gonzalo Ziegler Rodriguez","doi":"10.1097/GOX.0000000000007375","DOIUrl":"10.1097/GOX.0000000000007375","url":null,"abstract":"<p><strong>Background: </strong>Surgical intervention, particularly sentinel lymph node and lymph node dissection, is essential in managing melanoma, targeting locoregional disease. Our aim was to elucidate risk factors for postoperative lymphatic complications in melanoma patients undergoing lymph node surgery in Peru.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted, reviewing records of melanoma patients who underwent lymphatic surgery at the Instituto Nacional de Enfermedades Neoplásicas from 2010 to 2019. Descriptive statistics and logistic regression analyses were performed to identify predictors of lymphatic complications.</p><p><strong>Results: </strong>The study included 699 melanoma patients (mean age 60.70 y, 51.4% women). Most patients were Hispanic (99.3%) and from Lima (52.8%), with lower extremity involvement being common. Surgical interventions included wide local excision (56.9%), sentinel lymph node surgery (67%), and lymph node dissection (32.3%). Complications at the site of lymph node dissection included wound dehiscence (1.6%), infection (6.2%), lymphoceles (5.7%), and lymphedema (2.7%). Multivariate analysis identified lymphatic invasion (odds ratio [OR] = 2.601, 95% confidence interval [CI]: 1.232-5.491) and positive lymph node pathology (OR = 2.066, 95% CI: 1.034-4.127) as risk factors, whereas primary lesion location in the upper extremity (OR = 0.055, 95% CI: 0.007-0.408) and trunk (OR = 0.106, 95% CI: 0.014-0.818) were protective factors.</p><p><strong>Conclusions: </strong>Key risk factors for postoperative lymphatic complications in melanoma patients undergoing lymph node surgery include lower extremity involvement, lymph node dissections, lymphatic invasion, and positive lymph nodes. Understanding these risk factors can help clinicians optimize management strategies to reduce postoperative lymphatic complications.</p>","PeriodicalId":20149,"journal":{"name":"Plastic and Reconstructive Surgery Global Open","volume":"14 1","pages":"e7375"},"PeriodicalIF":1.8,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12788895/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145952822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-09eCollection Date: 2026-01-01DOI: 10.1097/GOX.0000000000007465
Mohammadhossein Hesamirostami, Sami Hesamirostami, Sanli Hesamirostami
[This corrects the article DOI: 10.1097/GOX.0000000000007323.].
[这更正了文章DOI: 10.1097/GOX.0000000000007323.]。
{"title":"Erratum: Innovative Preoperative Mathematical Suggestion for Vertical Incision in Mammaplasty: Erratum.","authors":"Mohammadhossein Hesamirostami, Sami Hesamirostami, Sanli Hesamirostami","doi":"10.1097/GOX.0000000000007465","DOIUrl":"10.1097/GOX.0000000000007465","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1097/GOX.0000000000007323.].</p>","PeriodicalId":20149,"journal":{"name":"Plastic and Reconstructive Surgery Global Open","volume":"14 1","pages":"e7465"},"PeriodicalIF":1.8,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12788891/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145952906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Gender Diversity in Plastic Surgery: Progress and Perspectives From Qatar.","authors":"Mohamed Badie Ahmed, Fatima Saoud Al-Mohannadi, Abeer Alsherawi","doi":"10.1097/GOX.0000000000007415","DOIUrl":"10.1097/GOX.0000000000007415","url":null,"abstract":"","PeriodicalId":20149,"journal":{"name":"Plastic and Reconstructive Surgery Global Open","volume":"14 1","pages":"e7415"},"PeriodicalIF":1.8,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12783999/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145952841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-08eCollection Date: 2026-01-01DOI: 10.1097/GOX.0000000000007401
Haad A Arif, Bilal Khilfeh, Fatima Z Arif, Dainn Woo, Simon T Moore, Emmi Deckard, Ronit Wollstein, Stuart Kuschner
Background: Despite the ability of both plastic surgeons and orthopedic surgeons to treat hand and wrist injuries, significant differences exist in clinical practice between hand surgeons with differing residency training backgrounds. This study sought to investigate the influence of residency training on medicolegal exposure among hand surgeons trained in orthopedic and plastic and reconstructive surgery (PRS).
Methods: The Westlaw database was queried for all jury verdicts and settlements related to hand and wrist surgery and filed directly against an orthopedic or PRS hand surgeon. Extracted data included patient and defendant demographics, alleged negligence, damages, and payouts.
Results: A total of 66 cases out of 3933 were included. A defendant verdict was reached in 55 (83.3%) cases. The average monetary award was $2.1 million. The most common preceding treatment was fracture repair (n = 20, 30.3%) and carpal tunnel release (n = 13, 19.7%). Out of 66 cases, 52 (78.8%) were levied against orthopedic-trained hand surgeons. Therapeutic delay (P = 0.0068) or patient death (P = 0.0242) were predictive factors of a plaintiff verdict. PRS surgeons faced greater risks of litigation in cases following soft tissue repair, therapeutic delay, or negligence requiring an amputation. Conversely, orthopedic surgeons were more likely to face litigation following fracture repair.
Conclusions: Although specialty training of hand surgeons alone does not considerably influence the risk of facing medical malpractice litigation, differences in medicolegal trends within hand surgery reflect key differences in prevailing residency training emphases, clinical exposure, and geographic practice distribution between orthopedic- and PRS-trained hand surgeons.
{"title":"A Comparative Risk Analysis of Malpractice Claims in Hand Surgeons Trained in Plastic and Orthopedic Surgery.","authors":"Haad A Arif, Bilal Khilfeh, Fatima Z Arif, Dainn Woo, Simon T Moore, Emmi Deckard, Ronit Wollstein, Stuart Kuschner","doi":"10.1097/GOX.0000000000007401","DOIUrl":"10.1097/GOX.0000000000007401","url":null,"abstract":"<p><strong>Background: </strong>Despite the ability of both plastic surgeons and orthopedic surgeons to treat hand and wrist injuries, significant differences exist in clinical practice between hand surgeons with differing residency training backgrounds. This study sought to investigate the influence of residency training on medicolegal exposure among hand surgeons trained in orthopedic and plastic and reconstructive surgery (PRS).</p><p><strong>Methods: </strong>The Westlaw database was queried for all jury verdicts and settlements related to hand and wrist surgery and filed directly against an orthopedic or PRS hand surgeon. Extracted data included patient and defendant demographics, alleged negligence, damages, and payouts.</p><p><strong>Results: </strong>A total of 66 cases out of 3933 were included. A defendant verdict was reached in 55 (83.3%) cases. The average monetary award was $2.1 million. The most common preceding treatment was fracture repair (n = 20, 30.3%) and carpal tunnel release (n = 13, 19.7%). Out of 66 cases, 52 (78.8%) were levied against orthopedic-trained hand surgeons. Therapeutic delay (<i>P</i> = 0.0068) or patient death (<i>P</i> = 0.0242) were predictive factors of a plaintiff verdict. PRS surgeons faced greater risks of litigation in cases following soft tissue repair, therapeutic delay, or negligence requiring an amputation. Conversely, orthopedic surgeons were more likely to face litigation following fracture repair.</p><p><strong>Conclusions: </strong>Although specialty training of hand surgeons alone does not considerably influence the risk of facing medical malpractice litigation, differences in medicolegal trends within hand surgery reflect key differences in prevailing residency training emphases, clinical exposure, and geographic practice distribution between orthopedic- and PRS-trained hand surgeons.</p>","PeriodicalId":20149,"journal":{"name":"Plastic and Reconstructive Surgery Global Open","volume":"14 1","pages":"e7401"},"PeriodicalIF":1.8,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12784001/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145952830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-08eCollection Date: 2026-01-01DOI: 10.1097/GOX.0000000000007368
Andrew Hannoudi, Jeffrey E Janis
Background: "Pipelining" is a phenomenon whereby a residency program repeatedly matches individuals from the same medical school across several application cycles. This is potentially disadvantageous to qualified applicants without a history of institutional legacy at their schools. We aimed to evaluate the prevalence of pipelining by US integrated plastic surgery residency programs to promote an equitable playing field for future applicants.
Methods: An analysis of every Accreditation Council for Graduate Medical Education-accredited US integrated plastic surgery residency program was conducted. The graduated medical schools of 2229 current and former plastic surgery residents were collected. Pipeline scores were defined as the ratio of total residents to number of unique medical schools represented at the program (PipelineC, current residents; PipelineC+F, current and former residents). Programs were stratified by geographic location and by affiliation with the top 25 medical schools that graduate plastic surgery residents.
Results: The average PipelineC score was 1.23, and the average PipelineC+F score was 1.45. Programs in the Northeast had the highest PipelineC (P < 0.001) and PipelineC+F (P = 0.042) scores. Programs affiliated with the top 25 medical schools had higher PipelineC (P < 0.001) and PipelineC+F (P = 0.015) scores than all other programs. Overall, 17.4% of current and 22.6% of former residents matched at their home residency programs.
Conclusions: There is a measurable prevalence of pipelining in plastic surgery, especially in the Northeastern US and at programs affiliated with medical schools with historical match success. Fostering an inclusive and meritocratic match process will benefit the field of plastic surgery entirely.
{"title":"Nationwide Analysis of Pipelining and Medical School Affiliation in the US Integrated Plastic Surgery Residency Match.","authors":"Andrew Hannoudi, Jeffrey E Janis","doi":"10.1097/GOX.0000000000007368","DOIUrl":"10.1097/GOX.0000000000007368","url":null,"abstract":"<p><strong>Background: </strong>\"Pipelining\" is a phenomenon whereby a residency program repeatedly matches individuals from the same medical school across several application cycles. This is potentially disadvantageous to qualified applicants without a history of institutional legacy at their schools. We aimed to evaluate the prevalence of pipelining by US integrated plastic surgery residency programs to promote an equitable playing field for future applicants.</p><p><strong>Methods: </strong>An analysis of every Accreditation Council for Graduate Medical Education-accredited US integrated plastic surgery residency program was conducted. The graduated medical schools of 2229 current and former plastic surgery residents were collected. Pipeline scores were defined as the ratio of total residents to number of unique medical schools represented at the program (Pipeline<sup>C</sup>, current residents; Pipeline<sup>C+F</sup>, current and former residents). Programs were stratified by geographic location and by affiliation with the top 25 medical schools that graduate plastic surgery residents.</p><p><strong>Results: </strong>The average Pipeline<sup>C</sup> score was 1.23, and the average Pipeline<sup>C+F</sup> score was 1.45. Programs in the Northeast had the highest Pipeline<sup>C</sup> (<i>P</i> < 0.001) and Pipeline<sup>C+F</sup> (<i>P</i> = 0.042) scores. Programs affiliated with the top 25 medical schools had higher Pipeline<sup>C</sup> (<i>P</i> < 0.001) and Pipeline<sup>C+F</sup> (<i>P</i> = 0.015) scores than all other programs. Overall, 17.4% of current and 22.6% of former residents matched at their home residency programs.</p><p><strong>Conclusions: </strong>There is a measurable prevalence of pipelining in plastic surgery, especially in the Northeastern US and at programs affiliated with medical schools with historical match success. Fostering an inclusive and meritocratic match process will benefit the field of plastic surgery entirely.</p>","PeriodicalId":20149,"journal":{"name":"Plastic and Reconstructive Surgery Global Open","volume":"14 1","pages":"e7368"},"PeriodicalIF":1.8,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12784003/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145952867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Orthoplastic surgery integrates orthopedic and plastic surgical expertise and principles in the context of complex lower limb pathologies involving bone and soft tissue. Rapid advancements in the field have revolutionized the multidisciplinary approach to such conditions and have allowed for advancements in techniques used and outcomes achieved. We performed the first bibliometric analysis focused on the 100 most-cited articles related to lower limb orthoplastic surgery (LLOS) to analyze emerging trends and provide guidance for future research in the field.
Methods: The 100 most-cited articles related to LLOS were identified on Web of Science across all databases and all years. Study details, including total citation count, study outcomes, primary orthoplastic pathology, and the modality used, were extracted, and the level of evidence was also assessed.
Results: The 100 most-cited articles in LLOS were referenced by a total of 12,225 articles. Citation counts per article ranged significantly from 62 to 691 (mean: 103 ± 88.9). The majority of studies were retrospective cohorts (n = 59, mean citations: 139.8 ± 110.5). Only 1 study achieved level I status, highlighting a significant gap in methodological quality research within the field. Most studies focused on clinical outcomes (n = 88), whereas trauma and open fractures were the most common pathologies (n = 94), and flap coverage was the most common orthoplastic modality (n = 79) discussed.
Conclusions: Overall, the majority of the most influential articles in LLOS are of lower level evidence. Future research should prioritize improving methodological rigor and applying orthoplastic principles beyond trauma care.
{"title":"Trends in Lower Limb Orthoplastic Surgery: A Bibliometric Analysis.","authors":"Panagiotis Bompolas, Sina Dehnadi, Francesca Ruccia, Kian Daneshi, Ankur Khajuria, Apoorva Khajuria","doi":"10.1097/GOX.0000000000007409","DOIUrl":"10.1097/GOX.0000000000007409","url":null,"abstract":"<p><strong>Background: </strong>Orthoplastic surgery integrates orthopedic and plastic surgical expertise and principles in the context of complex lower limb pathologies involving bone and soft tissue. Rapid advancements in the field have revolutionized the multidisciplinary approach to such conditions and have allowed for advancements in techniques used and outcomes achieved. We performed the first bibliometric analysis focused on the 100 most-cited articles related to lower limb orthoplastic surgery (LLOS) to analyze emerging trends and provide guidance for future research in the field.</p><p><strong>Methods: </strong>The 100 most-cited articles related to LLOS were identified on Web of Science across all databases and all years. Study details, including total citation count, study outcomes, primary orthoplastic pathology, and the modality used, were extracted, and the level of evidence was also assessed.</p><p><strong>Results: </strong>The 100 most-cited articles in LLOS were referenced by a total of 12,225 articles. Citation counts per article ranged significantly from 62 to 691 (mean: 103 ± 88.9). The majority of studies were retrospective cohorts (n = 59, mean citations: 139.8 ± 110.5). Only 1 study achieved level I status, highlighting a significant gap in methodological quality research within the field. Most studies focused on clinical outcomes (n = 88), whereas trauma and open fractures were the most common pathologies (n = 94), and flap coverage was the most common orthoplastic modality (n = 79) discussed.</p><p><strong>Conclusions: </strong>Overall, the majority of the most influential articles in LLOS are of lower level evidence. Future research should prioritize improving methodological rigor and applying orthoplastic principles beyond trauma care.</p>","PeriodicalId":20149,"journal":{"name":"Plastic and Reconstructive Surgery Global Open","volume":"14 1","pages":"e7409"},"PeriodicalIF":1.8,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12784007/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145952908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-08eCollection Date: 2026-01-01DOI: 10.1097/GOX.0000000000007399
Noah Oiknine, Dominique Tremblay, Géraldine Jacquemin, Catherine Dansereau, Philippe Ménard, Josée Dubois, Marie-Ève Lamarche, Marion Lack, Elie Boghossian
Background: Restoring upper extremity (UE) function has consistently been ranked by tetraplegic patients as the most important function that would improve functional independence and quality of life. Given the reported underuse of UE reconstruction in spinal cord injury (SCI) and the complexity of these patients, an interdisciplinary clinic offering the full spectrum of UE reconstruction for this population was developed, taking into account known barriers.
Methods: We describe the development and functioning of our interdisciplinary TetraHand clinic with consideration for recognized barriers to implementation. We herein share the lessons we have learned and describe our experience since the introduction of the clinic in 2019.
Results: In the initial 5-year period since the establishment of the interdisciplinary Montreal TetraHand Clinic, 65 tetraplegic patients were seen in consultation, and 23 underwent UE reconstructive surgery (18 bilateral, 5 unilateral), yielding a 35.4% conversion rate. Compared with the previous model of care under which only 10 patients underwent unilateral UE reconstructive surgery over a 12-year period, the interdisciplinary clinic achieved a 5.75-fold increase in annual case volume.
Conclusions: Building a successful TetraHand program requires the recruitment of a dedicated interdisciplinary team including hand surgeons, physiatrists, therapists, the establishment of a vast referral network, and a targeted clinical strategy to address barriers to providing care for the complex SCI population. This interdisciplinary clinical model has led to a significant increase in operative volumes and referrals, enabling us to provide comprehensive UE reconstructive surgery for SCI patients.
{"title":"Building an Interdisciplinary Clinic for Upper Extremity Reconstruction in Spinal Cord Injury: The Montreal TetraHand Experience.","authors":"Noah Oiknine, Dominique Tremblay, Géraldine Jacquemin, Catherine Dansereau, Philippe Ménard, Josée Dubois, Marie-Ève Lamarche, Marion Lack, Elie Boghossian","doi":"10.1097/GOX.0000000000007399","DOIUrl":"10.1097/GOX.0000000000007399","url":null,"abstract":"<p><strong>Background: </strong>Restoring upper extremity (UE) function has consistently been ranked by tetraplegic patients as the most important function that would improve functional independence and quality of life. Given the reported underuse of UE reconstruction in spinal cord injury (SCI) and the complexity of these patients, an interdisciplinary clinic offering the full spectrum of UE reconstruction for this population was developed, taking into account known barriers.</p><p><strong>Methods: </strong>We describe the development and functioning of our interdisciplinary TetraHand clinic with consideration for recognized barriers to implementation. We herein share the lessons we have learned and describe our experience since the introduction of the clinic in 2019.</p><p><strong>Results: </strong>In the initial 5-year period since the establishment of the interdisciplinary Montreal TetraHand Clinic, 65 tetraplegic patients were seen in consultation, and 23 underwent UE reconstructive surgery (18 bilateral, 5 unilateral), yielding a 35.4% conversion rate. Compared with the previous model of care under which only 10 patients underwent unilateral UE reconstructive surgery over a 12-year period, the interdisciplinary clinic achieved a 5.75-fold increase in annual case volume.</p><p><strong>Conclusions: </strong>Building a successful TetraHand program requires the recruitment of a dedicated interdisciplinary team including hand surgeons, physiatrists, therapists, the establishment of a vast referral network, and a targeted clinical strategy to address barriers to providing care for the complex SCI population. This interdisciplinary clinical model has led to a significant increase in operative volumes and referrals, enabling us to provide comprehensive UE reconstructive surgery for SCI patients.</p>","PeriodicalId":20149,"journal":{"name":"Plastic and Reconstructive Surgery Global Open","volume":"14 1","pages":"e7399"},"PeriodicalIF":1.8,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12784000/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145952899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cancer-related hypercalcemia typically indicates poor prognosis and occurs most commonly in squamous cell carcinoma cases. However, its occurrence in patients with verrucous carcinoma, a clinically indolent subtype, has never been reported. We present the first documented case of verrucous carcinoma-related hypercalcemia caused by parathyroid hormone-related protein (PTHrP) production. A 49-year-old man presented with weight loss, fatigue, and severe hypercalcemia. He had a 3-year history of a scrotal mass that was diagnosed as perineal verrucous carcinoma based on histopathologic examination. Laboratory results revealed markedly elevated calcium (13.0 mg/dL) and PTHrP (6.6 pmol/L) levels, confirming tumor-associated hypercalcemia. The cauliflower-like tumor measuring 17 × 15 cm involved the penis and scrotum. Complete surgical resection with bilateral inguinal lymph node dissection was performed. Split-thickness skin grafts provided wound coverage over the large perineal defect. Immunohistochemical staining confirmed PTHrP production by tumor cells that had invaded beyond the basement membrane. Postoperative calcium (9.8 mg/dL) and PTHrP (<1.1 pmol/L) levels normalized rapidly. Histopathology confirmed verrucous carcinoma with dermal invasion; however, no lymph node metastasis occurred. Pseudomonas aeruginosa infection developed but resolved with topical treatment. Six-month follow-up magnetic resonance imaging showed no recurrence with sustained hypercalcemia resolution. This first documented case linking PTHrP-mediated hypercalcemia to verrucous carcinoma demonstrates that paraneoplastic hypercalcemia can occur in this typically indolent malignancy when dermal invasion occurs. Recognition of this rare syndrome is crucial for optimal management. Complete surgical excision achieved both oncological control and resolution of systemic complications, highlighting the importance of aggressive treatment when basement membrane invasion is present.
{"title":"Perineal Verrucous Carcinoma Associated With Hypercalcemia: First Clinical Report of Parathyroid Hormone-Related Protein-producing Tumor.","authors":"Wakana Oka, Hiroaki Kuwahara, Norio Motoda, Mayumi Ishikawa, Rei Ogawa, Satoshi Akaishi","doi":"10.1097/GOX.0000000000007395","DOIUrl":"10.1097/GOX.0000000000007395","url":null,"abstract":"<p><p>Cancer-related hypercalcemia typically indicates poor prognosis and occurs most commonly in squamous cell carcinoma cases. However, its occurrence in patients with verrucous carcinoma, a clinically indolent subtype, has never been reported. We present the first documented case of verrucous carcinoma-related hypercalcemia caused by parathyroid hormone-related protein (PTHrP) production. A 49-year-old man presented with weight loss, fatigue, and severe hypercalcemia. He had a 3-year history of a scrotal mass that was diagnosed as perineal verrucous carcinoma based on histopathologic examination. Laboratory results revealed markedly elevated calcium (13.0 mg/dL) and PTHrP (6.6 pmol/L) levels, confirming tumor-associated hypercalcemia. The cauliflower-like tumor measuring 17 × 15 cm involved the penis and scrotum. Complete surgical resection with bilateral inguinal lymph node dissection was performed. Split-thickness skin grafts provided wound coverage over the large perineal defect. Immunohistochemical staining confirmed PTHrP production by tumor cells that had invaded beyond the basement membrane. Postoperative calcium (9.8 mg/dL) and PTHrP (<1.1 pmol/L) levels normalized rapidly. Histopathology confirmed verrucous carcinoma with dermal invasion; however, no lymph node metastasis occurred. <i>Pseudomonas aeruginosa</i> infection developed but resolved with topical treatment. Six-month follow-up magnetic resonance imaging showed no recurrence with sustained hypercalcemia resolution. This first documented case linking PTHrP-mediated hypercalcemia to verrucous carcinoma demonstrates that paraneoplastic hypercalcemia can occur in this typically indolent malignancy when dermal invasion occurs. Recognition of this rare syndrome is crucial for optimal management. Complete surgical excision achieved both oncological control and resolution of systemic complications, highlighting the importance of aggressive treatment when basement membrane invasion is present.</p>","PeriodicalId":20149,"journal":{"name":"Plastic and Reconstructive Surgery Global Open","volume":"14 1","pages":"e7395"},"PeriodicalIF":1.8,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12783993/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145952904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-08eCollection Date: 2026-01-01DOI: 10.1097/GOX.0000000000007412
Carolina A Mariluis, Diego Lagonegro, Fernanda Cavallieri, Patricia Barrera
Diagnosing late-onset complications after hyaluronic acid (HA) fillers can be challenging, particularly when clinical symptoms are mild. Although ultrasound (US) is widely regarded as the gold standard for evaluating facial fillers, it has limitations in certain scenarios. We report the case of a 30-year-old woman who developed a persistent sensation of pressure in the mental region 2 years after chin augmentation with a high-G-prime HA filler (brand unknown). Two high-frequency US examinations performed by experienced radiologists identified only a small supraperiosteal bolus, without significant deposits to explain the symptoms. High-resolution facial magnetic resonance imaging (MRI) unexpectedly revealed a substantial amount of HA diffusely dispersed within the subcutaneous fat of the chin, undetectable by US. A targeted injection of hyaluronidase (150 IU) was administered, resulting in complete symptom relief. Follow-up MRI confirmed the resolution of the HA deposits. This case highlighted a diagnostic blind spot of US when filler material was diffusely infiltrated into adipose tissue and lacked nodular morphology. MRI, although not routinely used due to cost and availability, may provide crucial complementary information in cases of clinical-radiological discordance. This case suggested that MRI may provide useful complementary information in selected scenarios of clinical-radiological discrepancy.
{"title":"Where Is the Filler? Magnetic Resonance Imaging Reveals Hidden Hyaluronic Acid in a Delayed Chin Complication.","authors":"Carolina A Mariluis, Diego Lagonegro, Fernanda Cavallieri, Patricia Barrera","doi":"10.1097/GOX.0000000000007412","DOIUrl":"10.1097/GOX.0000000000007412","url":null,"abstract":"<p><p>Diagnosing late-onset complications after hyaluronic acid (HA) fillers can be challenging, particularly when clinical symptoms are mild. Although ultrasound (US) is widely regarded as the gold standard for evaluating facial fillers, it has limitations in certain scenarios. We report the case of a 30-year-old woman who developed a persistent sensation of pressure in the mental region 2 years after chin augmentation with a high-G-prime HA filler (brand unknown). Two high-frequency US examinations performed by experienced radiologists identified only a small supraperiosteal bolus, without significant deposits to explain the symptoms. High-resolution facial magnetic resonance imaging (MRI) unexpectedly revealed a substantial amount of HA diffusely dispersed within the subcutaneous fat of the chin, undetectable by US. A targeted injection of hyaluronidase (150 IU) was administered, resulting in complete symptom relief. Follow-up MRI confirmed the resolution of the HA deposits. This case highlighted a diagnostic blind spot of US when filler material was diffusely infiltrated into adipose tissue and lacked nodular morphology. MRI, although not routinely used due to cost and availability, may provide crucial complementary information in cases of clinical-radiological discordance. This case suggested that MRI may provide useful complementary information in selected scenarios of clinical-radiological discrepancy.</p>","PeriodicalId":20149,"journal":{"name":"Plastic and Reconstructive Surgery Global Open","volume":"14 1","pages":"e7412"},"PeriodicalIF":1.8,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12783995/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145952865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-08eCollection Date: 2026-01-01DOI: 10.1097/GOX.0000000000007397
Nina Hadzimustafic, Emma Avery, Jeffrey Chen, Mahmud Zeidan, Siba Haykal
Background: Prevention of wound complications of the neoumbilicus in deep inferior epigastric perforator breast reconstruction increases patient cosmetic satisfaction. The reported incidence of umbilical wound complications is between 3% and 18% in the current literature, necessitating improved prediction of such complications.
Methods: The authors evaluated a retrospective cohort of 30 consecutive patients who underwent deep inferior epigastric perforator breast reconstruction during a 1.5-year period at the University Health Network by a single surgeon. Umbilical perfusion was intraoperatively measured by the SPY quantification of perfusion (QP) system with indocyanine green angiography. Postoperative outcomes were assessed in the outpatient clinic and classified as no wound complication, minor wound dehiscence, partial, or total necrosis.
Results: A total of 30 patients were included: 19 with no complications, 2 had minor wounds, 3 had dehiscence, 3 had partial necrosis, and 3 had total necrosis. The average patient age was 50 ± 10 years; the average body mass index was 28 ± 4 kg/m2. Seven (23%) patients had a smoking history, and 1 (3%) patient was an active smoker. Patients with an average SPY-QP of 66% or higher had no umbilical wound complications. An average SPY-QP of 31% or lower predicts minor wound complications, 26% or lower predicts partial or total necrosis, and 13% or lower predicts total necrosis.
Conclusions: Intraoperative indocyanine green angiography is an excellent adjunct to clinical assessment for predicting umbilical wound complications. A surgeon can use SPY-QP to make intraoperative decisions to improve outcomes if quantitative perfusion is poor.
{"title":"Intraoperative Umbilical Perfusion Assessment Following Deep Inferior Epigastric Perforator Breast Reconstruction Using Indocyanine Green.","authors":"Nina Hadzimustafic, Emma Avery, Jeffrey Chen, Mahmud Zeidan, Siba Haykal","doi":"10.1097/GOX.0000000000007397","DOIUrl":"10.1097/GOX.0000000000007397","url":null,"abstract":"<p><strong>Background: </strong>Prevention of wound complications of the neoumbilicus in deep inferior epigastric perforator breast reconstruction increases patient cosmetic satisfaction. The reported incidence of umbilical wound complications is between 3% and 18% in the current literature, necessitating improved prediction of such complications.</p><p><strong>Methods: </strong>The authors evaluated a retrospective cohort of 30 consecutive patients who underwent deep inferior epigastric perforator breast reconstruction during a 1.5-year period at the University Health Network by a single surgeon. Umbilical perfusion was intraoperatively measured by the SPY quantification of perfusion (QP) system with indocyanine green angiography. Postoperative outcomes were assessed in the outpatient clinic and classified as no wound complication, minor wound dehiscence, partial, or total necrosis.</p><p><strong>Results: </strong>A total of 30 patients were included: 19 with no complications, 2 had minor wounds, 3 had dehiscence, 3 had partial necrosis, and 3 had total necrosis. The average patient age was 50 ± 10 years; the average body mass index was 28 ± 4 kg/m<sup>2</sup>. Seven (23%) patients had a smoking history, and 1 (3%) patient was an active smoker. Patients with an average SPY-QP of 66% or higher had no umbilical wound complications. An average SPY-QP of 31% or lower predicts minor wound complications, 26% or lower predicts partial or total necrosis, and 13% or lower predicts total necrosis.</p><p><strong>Conclusions: </strong>Intraoperative indocyanine green angiography is an excellent adjunct to clinical assessment for predicting umbilical wound complications. A surgeon can use SPY-QP to make intraoperative decisions to improve outcomes if quantitative perfusion is poor.</p>","PeriodicalId":20149,"journal":{"name":"Plastic and Reconstructive Surgery Global Open","volume":"14 1","pages":"e7397"},"PeriodicalIF":1.8,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12783989/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145952912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}