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3D Neck Lift: A Dynamic Approach to Submental Anatomy. 三维颈部提升:颏下解剖的动态方法。
IF 1.8 Q3 SURGERY Pub Date : 2026-02-02 eCollection Date: 2026-02-01 DOI: 10.1097/GOX.0000000000007463
Marc Divaris, Sydney Ohana

Background: Traditional neck rejuvenation-liposuction, platysmaplasty, and skin redraping-overlooks intrinsic mandibular-cervical asymmetry,digastric insertions, platysmal discontinuity, submandibular gland descent, and age-related hyoid retrodisplacement. These influence submental contour and require a tridimensional, anatomy-based correction.

Methods: A retrospective study of 177 patients (99 women, 78 men; mean age 59 y, range 26-78 y) undergoing isolated neck rejuvenation (2003-2024) assessed outcomes of the 3D neck lift, which has been used since 2018 in Knize stage II-III and stage IV cases. The technique combines a triangular platysma myectomy forming a stabilizing neo-floor, partial digastric resection, and subplatysmal fat control, with platelet-rich plasma (PRP) (stages III-IV) or bipolar radiofrequency (stage IV). Results were evaluated by complications, morphology, and satisfaction.

Results: Mandibular asymmetry (broad on the left side) was present in 92% of patients. Stage distribution was: I, 28%; II, 35%; III, 21%; and IV, 16%. Chin implants were added in 10%, PRP in 31%, and radiofrequency in 6%. Complications were minimal, consisting of 2 transient marginal mandibular pareses (<6 wk) and 10 seromas, only 3 of which occurred since 2020; all resolved after a single aspiration. Excellent or good cervicomental angle definition was achieved in 98% of cases, with 96% of patients satisfied or very satisfied.

Conclusions: The 3D neck lift offers a personalized, single-incision solution to submental rejuvenation, integrating natural asymmetry, triangular platysma resection, and fibrotic stabilization to restore a stable cervicomental angle with low morbidity. Adjuncts such as PRP or radiofrequency enhance advanced cases but are nonessential. This method provides a reliable, scar-sparing alternative for isolated neck rejuvenation.

背景:传统的颈部年轻化-吸脂、颈阔成形术和皮肤重铺-忽略了固有的下颌-颈椎不对称、二腹肌插入、颈阔不连续性、下颌下腺下降和与年龄相关的舌骨后移位。这些影响颏下轮廓,需要三维的、基于解剖学的校正。方法:回顾性研究177例(女性99例,男性78例,平均年龄59岁,范围26-78岁)接受孤立颈部年轻化(2003-2024)的患者,评估自2018年以来用于Knize II-III期和IV期病例的3D颈部提升的结果。该技术结合了三角脊髓型肌瘤切除术形成稳定的新基底、二腹肌部分切除和脊髓型下脂肪控制,以及富血小板血浆(PRP) (III-IV期)或双极射频(IV期)。结果通过并发症、形态学和满意度进行评估。结果:92%的患者下颌不对称(左侧偏宽)。分期分布为:1,28%;二世,35%;第三,21%;IV, 16%。下颌种植体占10%,PRP占31%,射频治疗占6%。结论:3D颈部提升术为颏下年轻化提供了一种个性化的单切口解决方案,结合了自然不对称、三角颈肌切除和纤维化稳定,恢复了稳定的颈椎角度,发病率低。诸如PRP或射频等辅助手段可以增强晚期病例,但不是必需的。这种方法为孤立颈部年轻化提供了可靠的、不留疤痕的替代方法。
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引用次数: 0
Minimally Invasive Endoscopic Palmaris Longus Abductorplasty for Severe Carpal Tunnel Syndrome and Thenar Muscle Paralysis Reconstruction. 微创内窥镜掌外展长肌成形术治疗严重腕管综合征及大鱼际肌瘫痪重建。
IF 1.8 Q3 SURGERY Pub Date : 2026-02-02 eCollection Date: 2026-02-01 DOI: 10.1097/GOX.0000000000007438
Dawn Sinn Yii Chia, Suraj Sajeev

Functional deficits in severe carpal tunnel syndrome arise from a combination of persistent diminished sensation and thenar muscle paralysis, leading to the disruption of thumb kinematics. Decompression alone does not address thenar atrophy. To restore thumb function, tendon transfers from donors, such as the palmaris longus, have been described. However, palmaris longus abductorplasty has disadvantages, including extensive dissection and large wounds, which increase the risk of higher morbidity, scarring, increased pain, and delayed rehabilitation. We introduce a minimally invasive endoscopic technique of tendon harvest for thenar abductorplasty to minimize morbidity. This technique can be used with a simultaneous endoscopic carpal tunnel decompression. The average surgical time was 47 minutes for combined endoscopic carpal tunnel decompression and tendon transfer procedures. The final outcomes at 6 months showed a pinch strength of 1-3.5 kgF, or 74.8% of the contralateral side. The introduction of the endoscopic technique for tendon transfer heralds a new direction in minimally invasive surgery.

严重腕管综合征的功能缺陷源于持续性感觉减退和大鱼际肌麻痹的结合,导致拇指运动中断。单纯减压并不能解决鱼际萎缩。为了恢复拇指功能,已经描述了来自供体的肌腱转移,例如掌长肌。然而,掌外展长肌成形术有缺点,包括广泛的剥离和较大的伤口,这增加了更高的发病率、疤痕、疼痛增加和延迟康复的风险。我们介绍一种微创内窥镜下肌腱采集技术,用于大鱼际外展成形术,以减少发病率。该技术可与内窥镜腕管减压术同时使用。联合内窥镜腕管减压和肌腱转移手术的平均手术时间为47分钟。6个月时的最终结果显示捏压强度为1-3.5 kgF,占对侧的74.8%。内镜下肌腱转移技术的引入预示着微创手术的新方向。
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引用次数: 0
The Role and Efficacy of NovoSorb Biodegradable Temporizing Matrix in Complex Reconstructive Wounds: A Systematic Review. NovoSorb可生物降解缓释基质在复杂创面重建中的作用和疗效:系统综述。
IF 1.8 Q3 SURGERY Pub Date : 2026-02-02 eCollection Date: 2026-02-01 DOI: 10.1097/GOX.0000000000007461
Omar H Shadid, Siuyan Pang, Basheer N Arnaout, Aleha Pillay, Beryl Tan, Cheng H Lo

Background: Managing complex wounds with exposed bone, tendons, metalware, or irradiated tissue is challenging. NovoSorb Biodegradable Temporizing Matrix (BTM) offers an alternative by promoting vascularization and neodermis formation. This review assessed the effectiveness of BTM in managing complex wounds, including those with vascular compromise (eg, periosteal stripping or denuded paratenon) or exposure to radiotherapy.

Methods: A systematic search of Embase, Ovid, Scopus, and PubMed was conducted. Inclusion criteria included wounds involving exposed bone, tendons, or radiotherapy exposure. Data were analyzed for clinical outcomes, demographic variables, and complications.

Results: A total of 208 patients across 34 studies were analyzed. The overall complication rate was 27.9%. Wounds with combined bone and tendon exposure and periosteal stripping or denuded paratenon had significantly higher complication rates than those with only exposed bone and tendon (57.1% versus 35.3%, P = 0.006). Denuded tendons only had significantly higher complication rates compared with intact tendons (38.9% versus 18.6%, P = 0.044). Across all wounds, the presence of periosteal stripping and/or denuded paratenon was linked to significantly more complications (40.0% versus 21.8%, P = 0.005). Chronic wounds were independently associated with a 4-fold increase in complication risk (P = 0.013). Upper extremity wounds had significantly lower complication rates than lower extremity wounds (odds ratio 0.295, P = 0.008). Increasing age was independently associated with poorer outcomes (odds ratio 1.015 per year, P = 0.039).

Conclusions: BTM is a valuable addition to the reconstructive armamentarium. However, complication rates in complex wounds are high, so careful clinical judgment is essential for their implementation.

背景:处理骨、肌腱、金属器皿或辐照组织暴露的复杂伤口是具有挑战性的。NovoSorb可生物降解延缓基质(BTM)通过促进血管化和新生皮形成提供了另一种选择。本综述评估了BTM治疗复杂伤口的有效性,包括血管受损(如骨膜剥离或剥脱的对腱膜)或放射治疗。方法:系统检索Embase、Ovid、Scopus、PubMed等文献。纳入标准包括骨、肌腱外露或放疗暴露的伤口。对数据进行临床结果、人口统计学变量和并发症的分析。结果:34项研究共分析了208例患者。总并发症发生率为27.9%。骨和肌腱联合暴露并骨膜剥离或脱脱的伤口并发症发生率明显高于仅暴露骨和肌腱的伤口(57.1%比35.3%,P = 0.006)。与完整肌腱相比,剥离肌腱的并发症发生率明显更高(38.9%比18.6%,P = 0.044)。在所有伤口中,骨膜剥离和/或脱落的旁腱膜的存在与更多的并发症相关(40.0%比21.8%,P = 0.005)。慢性伤口与并发症风险增加4倍独立相关(P = 0.013)。上肢创面并发症发生率明显低于下肢创面(优势比0.295,P = 0.008)。年龄增加与预后较差独立相关(比值比为1.015 /年,P = 0.039)。结论:BTM是一种有价值的修复器械。然而,复杂伤口的并发症发生率很高,因此谨慎的临床判断对其实施至关重要。
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引用次数: 0
Beyond Conventional Donor Tendons: Flexor Tendon Reconstruction with Fascia Lata-A Narrative Review and Case Illustration. 超越传统供体肌腱:用阔筋膜重建屈肌腱-叙述回顾和案例说明。
IF 1.8 Q3 SURGERY Pub Date : 2026-02-02 eCollection Date: 2026-02-01 DOI: 10.1097/GOX.0000000000007457
Carmine Scarlato, Rossella Pagliaro, Luigi Troisi, Giorgio Eugenio Pajardi, Macarena Vizcay

Background: Hand flexor tendon injuries can be treated with primary repair by direct tenorrhaphy or, when this option is not feasible, with secondary repair by reconstruction with tendon grafts. Commonly used autologous grafts include palmaris longus and plantaris; however, these may be congenitally absent or unavailable. Fascia lata (FL) is widely used for ligament and tendon reconstruction in other anatomical regions, but its use in hand surgery is rarely reported.

Methods: A narrative review of the literature was conducted using the PubMed and Scopus databases to identify clinical and experimental studies on the use of FL grafts in tendon reconstruction. Relevant case reports and series were analyzed to summarize indications, techniques, and outcomes. A representative clinical case is also presented to illustrate the use of FL in a 2-staged flexor tendon reconstruction.

Results: FL has demonstrated favorable biomechanical and histological properties across multiple sites including shoulder, knee, Achilles tendon, and upper limb, with satisfactory long-term outcomes. Only a few reports have described its use in hand flexor tendon reconstruction, generally noting good motion recovery and low donor-site morbidity. The reported case illustrates a successful 2-stage reconstruction of a flexor digitorum profundus tendon using a rolled FL graft in a 20-year-old patient.

Conclusions: FL represents a reliable and versatile autologous graft option when conventional donor tendons are unavailable. Further biomechanical and clinical research is needed to establish its long-term performance and optimal applications in hand surgery.

背景:手部屈肌腱损伤可以通过直接肌腱缝合进行初级修复,当这种方法不可行时,可以通过肌腱移植重建进行二级修复。常用的自体移植物包括掌长肌和跖骨;然而,这些可能是先天缺失或不可用的。阔筋膜(FL)广泛用于其他解剖区域的韧带和肌腱重建,但在手部手术中的应用很少报道。方法:使用PubMed和Scopus数据库对文献进行叙述性回顾,以确定FL移植物在肌腱重建中的临床和实验研究。对相关病例报告和系列进行分析,总结适应证、技术和结果。一个有代表性的临床病例也被提出来说明FL在两阶段屈肌腱重建中的应用。结果:FL在多个部位表现出良好的生物力学和组织学特性,包括肩部、膝关节、跟腱和上肢,具有令人满意的长期预后。只有少数报道描述了它在手部屈肌腱重建中的应用,通常注意到良好的运动恢复和低的供区发病率。本文报道了一名20岁的患者,采用滚FL移植成功地进行了2期指深屈肌腱重建。结论:当无法获得传统供体肌腱时,FL是一种可靠且通用的自体移植物选择。需要进一步的生物力学和临床研究来确定其长期性能和在手外科中的最佳应用。
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引用次数: 0
Acellular Dermal Matrix-Associated Recurrent Capsular Contracture in a Breast Augmentation Patient. 一例隆胸患者脱细胞性真皮基质相关性复发性包膜挛缩。
IF 1.8 Q3 SURGERY Pub Date : 2026-02-02 eCollection Date: 2026-02-01 DOI: 10.1097/GOX.0000000000007451
Sarah Petrecca, Hillary Nepon, Avi Islur, Joshua Vorstenbosch

Capsular contracture (CC) is a common complication following breast augmentation. Acellular dermal matrix (ADM) is increasingly used to reduce and treat CC in breast augmentation. However, rare cases of ADM-associated CC can occur. In this case report, we describe a 63-year-old breast augmentation patient who developed significant recurrent CC following subglandular augmentation, capsulectomies, and ADM-assisted revisions. Despite ADM coverage, the patient developed Baker grade 3 CC. Histologic and immunohistochemical analyses were performed on capsular tissue adjacent to visible ADM (study ADM) and on capsule without ADM contact (study capsule), and the results were compared with benign controls. Study ADM demonstrated histologic evidence of ADM resorption and increased fibrotic density. Study capsule exhibited the greatest capsule thickness. Immunohistochemistry revealed significantly elevated macrophages (CD68+, P < 0.0001), pro-inflammatory M1 macrophages (iNOS+, P < 0.05), and T cells (CD3+, P < 0.01) in both study ADM and study capsule compared with controls. Comparison of study ADM to study capsule revealed a higher macrophage burden near ADM (CD68+ P < 0.001, iNOS+ P = 0.6), whereas T cells (CD3+, CD4+, P < 0.05) were reduced. This case illustrates that ADM may paradoxically trigger an inflammatory reaction, resulting in ADM-associated CC despite its intended protective role. The observed immune dysregulation suggests that ADM resorption, in contrast to incorporation, may be a driver of capsule pathology. These findings underscore the need for further research into patient-specific immune responses to ADM and their implications for CC risk.

摘要包膜挛缩是隆胸术后常见的并发症。脱细胞真皮基质(ADM)在隆胸术中越来越多地用于减少和治疗CC。然而,极少数与adm相关的CC也会发生。在这个病例报告中,我们描述了一位63岁的隆胸患者,他在腺下隆胸、包膜切除术和adm辅助修复后出现了明显的复发性CC。尽管有ADM覆盖,患者仍发展为Baker级3 CC。对可见ADM附近的包膜组织(研究ADM)和未接触ADM的包膜组织(研究胶囊)进行组织学和免疫组织化学分析,并将结果与良性对照进行比较。研究显示组织学证据表明ADM吸收和纤维化密度增加。研究胶囊的胶囊厚度最大。免疫组化显示,与对照组相比,研究ADM和研究胶囊中巨噬细胞(CD68+, P < 0.0001)、促炎M1巨噬细胞(iNOS+, P < 0.05)和T细胞(CD3+, P < 0.01)均显著升高。研究ADM与研究胶囊的比较发现,ADM附近巨噬细胞负荷增加(CD68+ P < 0.001, iNOS+ P = 0.6), T细胞(CD3+、CD4+, P < 0.05)减少。本病例表明,ADM可能矛盾地引发炎症反应,导致ADM相关的CC,尽管其预期的保护作用。观察到的免疫失调表明,与掺入相反,ADM的吸收可能是胶囊病理的驱动因素。这些发现强调需要进一步研究患者对ADM的特异性免疫反应及其对CC风险的影响。
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引用次数: 0
Innovative Refinements in Robotic-assisted Transoral Free Flap Inset Using Mini-pharyngotomy. 微型咽切开术在机器人辅助经口自由皮瓣植入中的创新改进。
IF 1.8 Q3 SURGERY Pub Date : 2026-02-02 eCollection Date: 2026-02-01 DOI: 10.1097/GOX.0000000000007441
Nicole E Speck, Medea Rodriguez, Alexander Lunger, Pablo Pfister, Dirk J Schaefer, Maximilian Burger, John W Shuck, Rene D Largo, Tarek Ismail, Laurent Muller

Transoral robotic surgery (TORS) has revolutionized head and neck cancer treatment by offering minimally invasive access to challenging anatomical regions. The first TORS procedure was performed in 2003, using the da Vinci Surgical System to remove a vallecular cyst, demonstrating its feasibility in otolaryngology. In 2005, Hockstein et al advanced robotic applications for pharyngeal and laryngeal regions, making TORS a viable alternative to more invasive approaches, such as mandibulotomy for tumor resection. Initially used for small tumors, TORS has expanded to include larger tumors requiring free flap reconstruction for extensive oropharyngeal defects. Robotic surgery also continues to grow in other head and neck procedures, with increasing reports of robotic thyroidectomy and skull base procedures. As robotic techniques expand, challenges for reconstructive surgeons accustomed to open techniques may arise. It is imperative that plastic surgeons embrace new technology and innovate accordingly. This case series explored a novel, minimally invasive approach to transoral free flap inset and pedicle positioning using a nerve- and vessel-sparing mini-pharyngotomy. Four patients underwent robotic-assisted resection and free flap reconstruction, avoiding traditional mandibulotomy and lateral pharyngotomy, thus preserving critical structures such as the hypoglossal and lingual nerves. This method may reduce surgical morbidity, optimize pedicle transfer, and improve functional outcomes. All patients had successful reconstructions with no flap loss or fistulas, and follow-up ranged from 9 to 70 months. These findings suggest that robotic-assisted free flap inset with a mini-pharyngotomy is a safe, effective, and patient-centric alternative to conventional approaches in head and neck reconstruction.

经口机器人手术(TORS)通过提供具有挑战性的解剖区域的微创治疗,彻底改变了头颈部癌症的治疗。2003年进行了第一次TORS手术,使用达芬奇手术系统切除了一个小静脉囊肿,证明了其在耳鼻喉科的可行性。2005年,Hockstein等人推进了机器人在咽部和喉部的应用,使TORS成为更有创入路(如下颌切开术)的可行选择。tor最初用于小肿瘤,现已扩展到需要自由皮瓣重建广泛口咽缺损的较大肿瘤。机器人手术在其他头颈部手术中也继续增长,机器人甲状腺切除术和颅底手术的报道越来越多。随着机器人技术的发展,习惯开放技术的重建外科医生可能会面临挑战。整形外科医生必须接受新技术并进行相应的创新。本病例系列探讨了一种新颖的、微创的经口自由皮瓣插入和蒂定位方法,采用保留神经和血管的小咽切开术。4例患者采用机器人辅助切除和自由皮瓣重建,避免了传统的下颌切开术和侧咽切开术,从而保留了舌下神经和舌神经等关键结构。该方法可减少手术并发症,优化椎弓根转移,改善功能预后。所有患者均成功重建,无皮瓣丢失或瘘管,随访时间为9至70个月。这些研究结果表明,机器人辅助的自由皮瓣插入小咽切开术是一种安全、有效、以患者为中心的头颈部重建方法。
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引用次数: 0
Long-term Outcome After Correction of Lower Eyelid Retraction With Donor Sclera in Thyroid Eye Disease. 甲状腺眼病用供体巩膜矫正下眼睑后的远期疗效。
IF 1.8 Q3 SURGERY Pub Date : 2026-02-02 eCollection Date: 2026-02-01 DOI: 10.1097/GOX.0000000000007455
Kathrine Halsøy, Annette Morwena Hope, Calvin Foshaug, Dag Einar Lysebo, Eyvind Rødahl, Hans Olav Ueland

Background: Lower eyelid retraction is a common feature of thyroid eye disease (TED). Various spacer materials have been used for surgical correction, but long-term data on donor sclera are missing.

Methods: A retrospective study of all TED patients treated with donor sclera to correct lower eyelid retraction was performed at the Department of Ophthalmology, Haukeland University Hospital, from 1999 to 2023. Data were obtained from hospital records and follow-up examinations. Outcomes were graded as perfect (scleral show of 0 mm), acceptable (0 mm < scleral show ≤ 1 mm), and unacceptable (scleral show >1 mm).

Results: Thirty-five patients (29 women, 6 men) with a median age (range) of 57 (20-79) years and a median time from TED onset to surgery of 72 (12-468) months were included. At first follow-up, 3 (0.03-12) months postoperatively, scleral show improved significantly (P < 0.001) from 2 (1-6) mm preoperatively to 0 (0-4) mm, and margin reflex distance 2 (MRD2) decreased significantly from 7 (6-11) to 5 (4-9) mm. A perfect or acceptable result was achieved in 83% of patients. Estimated graft survival rates were 93.9% at 5 years and 54.2% at 25 years. At final follow-up, 84 (12-275) months postoperatively, a perfect or acceptable outcome was found in 46%. No significant difference (P = 0.808) was observed between the preoperative MRD2 of 7 (6-11) mm and long-term postoperative MRD2 of 7 (5-11) mm.

Conclusions: Correction of lower eyelid retraction with donor sclera in TED patients provides satisfactory short-term outcomes. However, over time, relapse of retraction commonly occurs.

背景:下眼睑挛缩是甲状腺性眼病(TED)的常见特征。各种各样的垫片材料已用于手术矫正,但供体巩膜的长期数据缺失。方法:回顾性分析1999年至2023年在豪克兰大学医院眼科接受供体巩膜矫治下睑挛缩的所有TED患者。数据来自医院记录和随访检查。结果分为完美(巩膜显示0 mm)、可接受(0 mm <巩膜显示≤1 mm)和不可接受(巩膜显示0 ~ 1 mm)。结果:纳入35例患者(女性29例,男性6例),中位年龄(范围)为57(20-79)岁,从TED发病到手术的中位时间为72(12-468)个月。在术后3(0.03-12)个月的首次随访中,巩膜从术前的2 (1-6)mm明显改善到0 (0-4)mm (P < 0.001),边缘反射距离2 (MRD2)从7 (6-11)mm显著降低到5 (4-9)mm。83%的患者获得了完美或可接受的结果。5年和25年的移植存活率分别为93.9%和54.2%。在术后84(12-275)个月的最后随访中,46%的患者获得完美或可接受的结果。术前MRD2为7 (6-11)mm,术后长期MRD2为7 (5-11)mm,两者间无显著性差异(P = 0.808)。结论:TED患者用供体巩膜矫正下睑挛缩可获得满意的近期效果。然而,随着时间的推移,通常会复发。
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引用次数: 0
Guide Needle-assisted Ultrasound-guided (SIBUS) Filler Injections: Improving Needle Visualization for Safer Aesthetic Procedures. 引导针辅助超声引导(SIBUS)填充物注射:改善针的可视化安全性美学程序。
IF 1.8 Q3 SURGERY Pub Date : 2026-01-29 eCollection Date: 2026-01-01 DOI: 10.1097/GOX.0000000000007326
Ascher Benjamin, Youkyoung Cho, Leonie Schelke, Peter J Velthuis, Ji-Soo Kim, Jin-Hyun Kim, Kyu-Ho Yi

This study evaluated whether echogenic needles improve ultrasound visibility during hyaluronic acid filler injections in the cheek-a high-risk area due to anatomical variability of facial vessels. In a single-patient in vivo setting, 3 types of needles (23G nonechogenic and 23G and 30G echogenic) were tested under ultrasound guidance. Echogenic needles showed better tip and shaft visibility across angles and depths, including dynamic movement. Reviewers noted greater procedural confidence and a reduced need for probe adjustment. These findings suggest that echogenic needles may enhance safety and precision in ultrasound-guided aesthetic procedures.

本研究评估了超声针是否能提高透明质酸填充剂在脸颊注射时的超声可见度——由于面部血管的解剖变异,这是一个高风险区域。在单例患者体内环境下,超声引导下检测3种类型的针头(23G无回声和23G和30G有回声)。回声针在不同角度和深度,包括动态运动,显示出更好的尖端和轴的可视性。审稿人注意到更大的程序信心和减少探头调整的需要。这些发现表明,超声针可以提高超声引导美容手术的安全性和准确性。
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引用次数: 0
Associations of Glycemic Control and Diabetes Duration With Dupuytren Disease in Men and Women With Type 1 and 2 Diabetes. 1型和2型糖尿病患者血糖控制和糖尿病病程与Dupuytren疾病的关系
IF 1.8 Q3 SURGERY Pub Date : 2026-01-28 eCollection Date: 2026-01-01 DOI: 10.1097/GOX.0000000000007435
Märta Backman, Jesper Nordenskjöld, Raquel Perez, Mattias Rydberg

Background: Dupuytren disease (DD) is a benign fibroproliferative disorder affecting the hand. Although diabetes mellitus is a known risk factor, the underlying mechanisms behind this association remain unclear. This study aimed to examine the relationship between glycemic control and DD in type 1 (T1D) and type 2 diabetes (T2D), and to identify other metabolic risk factors influencing DD risk.

Methods: In this retrospective registry study, data from the Swedish National Diabetes Register and the Skåne Healthcare Register were cross-linked. In total, 96,039 individuals aged 18 years or older with T1D or T2D were included. Sex-stratified, multivariable logistic regression models calculated associations between HbA1c levels and DD risk. Interaction analyses evaluated whether diabetes duration modified the association between HbA1c levels and DD risk.

Results: Longer diabetes duration consistently increased the risk of DD in both T1D and T2D groups. A trend toward increased DD risk with higher HbA1c levels was seen in T1D (P > 0.05). Higher body mass index was inversely associated with DD in men and women with T2D (P < 0.05). No interaction was observed between HbA1c levels and diabetes duration.

Conclusions: Diabetes duration seems to be a strong and independent risk factor for DD in T1D and T2D. Although a trend toward higher DD risk with elevated HbA1c was observed in T1D, no interaction with diabetes duration was found. A higher body mass index was associated with a lower risk of DD in individuals with T2D.

背景:Dupuytren病(DD)是一种影响手部的良性纤维增生性疾病。虽然糖尿病是一个已知的危险因素,但这种关联背后的潜在机制尚不清楚。本研究旨在探讨1型糖尿病(T1D)和2型糖尿病(T2D)患者血糖控制与DD之间的关系,并确定影响DD风险的其他代谢危险因素。方法:在这项回顾性登记研究中,来自瑞典国家糖尿病登记和sk医疗保健登记的数据被交叉链接。总共包括96039名18岁及以上的T1D或T2D患者。性别分层、多变量逻辑回归模型计算了HbA1c水平与DD风险之间的关联。相互作用分析评估糖尿病病程是否改变了HbA1c水平与DD风险之间的关系。结果:糖尿病病程越长,T1D和T2D患者发生DD的风险越高。在T1D患者中,HbA1c水平越高,DD风险越高(P < 0.05)。在男性和女性T2D患者中,较高的体重指数与DD呈负相关(P < 0.05)。未观察到HbA1c水平与糖尿病病程之间的相互作用。结论:糖尿病病程似乎是T1D和T2D患者发生DD的一个强大且独立的危险因素。虽然在T1D中观察到HbA1c升高导致DD风险增加的趋势,但未发现与糖尿病病程的相互作用。较高的体重指数与T2D患者较低的DD风险相关。
{"title":"Associations of Glycemic Control and Diabetes Duration With Dupuytren Disease in Men and Women With Type 1 and 2 Diabetes.","authors":"Märta Backman, Jesper Nordenskjöld, Raquel Perez, Mattias Rydberg","doi":"10.1097/GOX.0000000000007435","DOIUrl":"10.1097/GOX.0000000000007435","url":null,"abstract":"<p><strong>Background: </strong>Dupuytren disease (DD) is a benign fibroproliferative disorder affecting the hand. Although diabetes mellitus is a known risk factor, the underlying mechanisms behind this association remain unclear. This study aimed to examine the relationship between glycemic control and DD in type 1 (T1D) and type 2 diabetes (T2D), and to identify other metabolic risk factors influencing DD risk.</p><p><strong>Methods: </strong>In this retrospective registry study, data from the Swedish National Diabetes Register and the Skåne Healthcare Register were cross-linked. In total, 96,039 individuals aged 18 years or older with T1D or T2D were included. Sex-stratified, multivariable logistic regression models calculated associations between HbA1c levels and DD risk. Interaction analyses evaluated whether diabetes duration modified the association between HbA1c levels and DD risk.</p><p><strong>Results: </strong>Longer diabetes duration consistently increased the risk of DD in both T1D and T2D groups. A trend toward increased DD risk with higher HbA1c levels was seen in T1D (<i>P</i> > 0.05). Higher body mass index was inversely associated with DD in men and women with T2D (<i>P</i> < 0.05). No interaction was observed between HbA1c levels and diabetes duration.</p><p><strong>Conclusions: </strong>Diabetes duration seems to be a strong and independent risk factor for DD in T1D and T2D. Although a trend toward higher DD risk with elevated HbA1c was observed in T1D, no interaction with diabetes duration was found. A higher body mass index was associated with a lower risk of DD in individuals with T2D.</p>","PeriodicalId":20149,"journal":{"name":"Plastic and Reconstructive Surgery Global Open","volume":"14 1","pages":"e7435"},"PeriodicalIF":1.8,"publicationDate":"2026-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12851777/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146086532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Histological Evaluation of Dual-depth Poly-l-Lactic Acid and Hyaluronic Acid Injections. 双深度聚乳酸和透明质酸注射的组织学评价。
IF 1.8 Q3 SURGERY Pub Date : 2026-01-28 eCollection Date: 2026-01-01 DOI: 10.1097/GOX.0000000000007402
Gi-Woong Hong, You-Kyoung Cho, Nark-Kyoung Rho, Jong-Hee Lee, Livia Pedrosa Moura, Gladstone Eustaquio de Lima Faria, Iñigo De Felipe Garate, Nicholas Shannon, Kyu-Ho Yi

This single-case histological study evaluated the safety and tissue effects of dual-depth injections of poly-L-lactic acid (PLLA) and hyaluronic acid (HA)-based skin booster administered into the same anatomical region. A 77-year-old woman received PLLA in the subcutaneous fat layer and HA in the deep dermis/subdermal layer of the right jowl. The untreated left side served as a control. Histological analysis revealed that PLLA induced a localized foreign-body reaction with increased fibroblast activity, dense collagen, and elastic fiber formation in the subcutaneous layer, indicative of extracellular matrix remodeling. HA-treated dermal layers showed mild matrix compaction and low-grade inflammation, consistent with the hydration effects. There was no histological evidence of filler overlap or adverse interaction. Three-dimensional imaging further supported volumetric enhancement and tissue elevation on the treated side. The results demonstrate that when spatially separated by depth, PLLA and HA can exert independent, synergistic effects without compromising safety. This dual-layer approach may offer a novel strategy for targeted skin rejuvenation in clinical practice. In this single-patient case, layer-separated PLLA and HA elicited independent, compartment-specific tissue responses without observed interaction. Findings are descriptive and anecdotal and should not be generalized without larger, controlled studies incorporating quantitative volumetry and histomorphometry.

这项单例组织学研究评估了在同一解剖区域双深度注射聚l-乳酸(PLLA)和透明质酸(HA)皮肤增强剂的安全性和组织效应。一位77岁的女性接受了右下颌皮下脂肪层PLLA和真皮深层/真皮下层HA。未治疗的左侧作为对照。组织学分析显示,PLLA诱导了局部的异物反应,增加了成纤维细胞活性,致密的胶原蛋白和皮下层弹性纤维的形成,表明细胞外基质重塑。ha处理的真皮层显示轻度基质压实和轻度炎症,与水合作用一致。没有组织学证据表明填充物重叠或不良反应。三维成像进一步支持治疗侧的体积增强和组织提升。结果表明,当空间深度分开时,PLLA和HA可以在不影响安全性的情况下发挥独立的协同效应。这种双层方法可能为临床实践中有针对性的皮肤年轻化提供一种新的策略。在这个单例病例中,分层分离的PLLA和HA引起了独立的、室特异性的组织反应,没有观察到相互作用。研究结果是描述性和轶事性的,如果没有更大规模的对照研究,包括定量体积测定法和组织形态测定法,就不应该普遍化。
{"title":"Histological Evaluation of Dual-depth Poly-l-Lactic Acid and Hyaluronic Acid Injections.","authors":"Gi-Woong Hong, You-Kyoung Cho, Nark-Kyoung Rho, Jong-Hee Lee, Livia Pedrosa Moura, Gladstone Eustaquio de Lima Faria, Iñigo De Felipe Garate, Nicholas Shannon, Kyu-Ho Yi","doi":"10.1097/GOX.0000000000007402","DOIUrl":"10.1097/GOX.0000000000007402","url":null,"abstract":"<p><p>This single-case histological study evaluated the safety and tissue effects of dual-depth injections of poly-L-lactic acid (PLLA) and hyaluronic acid (HA)-based skin booster administered into the same anatomical region. A 77-year-old woman received PLLA in the subcutaneous fat layer and HA in the deep dermis/subdermal layer of the right jowl. The untreated left side served as a control. Histological analysis revealed that PLLA induced a localized foreign-body reaction with increased fibroblast activity, dense collagen, and elastic fiber formation in the subcutaneous layer, indicative of extracellular matrix remodeling. HA-treated dermal layers showed mild matrix compaction and low-grade inflammation, consistent with the hydration effects. There was no histological evidence of filler overlap or adverse interaction. Three-dimensional imaging further supported volumetric enhancement and tissue elevation on the treated side. The results demonstrate that when spatially separated by depth, PLLA and HA can exert independent, synergistic effects without compromising safety. This dual-layer approach may offer a novel strategy for targeted skin rejuvenation in clinical practice. In this single-patient case, layer-separated PLLA and HA elicited independent, compartment-specific tissue responses without observed interaction. Findings are descriptive and anecdotal and should not be generalized without larger, controlled studies incorporating quantitative volumetry and histomorphometry.</p>","PeriodicalId":20149,"journal":{"name":"Plastic and Reconstructive Surgery Global Open","volume":"14 1","pages":"e7402"},"PeriodicalIF":1.8,"publicationDate":"2026-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12851759/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146086525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Plastic and Reconstructive Surgery Global Open
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