S. Moallem, Mitra Asgharian Rezaee, A. Mohammadpour, M. Imenshahidi
{"title":"The effect of erythropoietin on cardiac and neurotoxicity induced by carbon monoxide poisoning","authors":"S. Moallem, Mitra Asgharian Rezaee, A. Mohammadpour, M. Imenshahidi","doi":"10.52547/phypha.27.1.2","DOIUrl":"https://doi.org/10.52547/phypha.27.1.2","url":null,"abstract":"","PeriodicalId":20151,"journal":{"name":"Physiology and Pharmacology","volume":"40 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88527660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E. Akbari, Reza Alizadeh Navaei, Motahareh Rouhi Ardeshiri
{"title":"Linear heart rate variability measures in Sickle cell disease compared to the healthy control subjects: A systematic review and mete-analysis study","authors":"E. Akbari, Reza Alizadeh Navaei, Motahareh Rouhi Ardeshiri","doi":"10.52547/phypha.26.2.10","DOIUrl":"https://doi.org/10.52547/phypha.26.2.10","url":null,"abstract":"","PeriodicalId":20151,"journal":{"name":"Physiology and Pharmacology","volume":"1 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88646254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effects of acute, sub-chronic and chronic chocolate consumption with different percent of cocoa/sugar on memory and EEG waves in rats","authors":"Gh. Hadian, M. Radahmadi, H. Alaei, Parham Reisi","doi":"10.52547/phypha.26.3.10","DOIUrl":"https://doi.org/10.52547/phypha.26.3.10","url":null,"abstract":"","PeriodicalId":20151,"journal":{"name":"Physiology and Pharmacology","volume":"9 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84309340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hossein Mostafavi, M. Hatami, M. Alipour, S. S. Mousavi, H. Feizi
{"title":"Effect of cinnamon on antioxidant content and ZO-1 gene expression in brain following middle cerebral artery occlusion in rats receiving high-fat diet","authors":"Hossein Mostafavi, M. Hatami, M. Alipour, S. S. Mousavi, H. Feizi","doi":"10.52547/phypha.27.1.4","DOIUrl":"https://doi.org/10.52547/phypha.27.1.4","url":null,"abstract":"","PeriodicalId":20151,"journal":{"name":"Physiology and Pharmacology","volume":"19 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86254894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lotfollah Rezagholizadeh, Masoud Ojarudi, A. Moradi, Ramin Salimnejad, Abbas Khonakdar-Tarsi, S. Matin, I. Feizi, A. Mohammadnia, M. Mazani
{"title":"Protective effects of Cinnamomum zeylanicum and Zingiber officinale extract against CCl4-induced acute kidney injury in rats","authors":"Lotfollah Rezagholizadeh, Masoud Ojarudi, A. Moradi, Ramin Salimnejad, Abbas Khonakdar-Tarsi, S. Matin, I. Feizi, A. Mohammadnia, M. Mazani","doi":"10.52547/phypha.26.2.6","DOIUrl":"https://doi.org/10.52547/phypha.26.2.6","url":null,"abstract":"","PeriodicalId":20151,"journal":{"name":"Physiology and Pharmacology","volume":"36 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76263102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Reyhaneh Khayamabed, Naeimeh Rezaie, Elnaz Poorgolizadeh, Farshad Homayouni Moghadam, Kianoush Dorminani, M. N. Nasr Esfahani
{"title":"Efficient Modified-mRNA Transfection in Neural Stem Cells","authors":"Reyhaneh Khayamabed, Naeimeh Rezaie, Elnaz Poorgolizadeh, Farshad Homayouni Moghadam, Kianoush Dorminani, M. N. Nasr Esfahani","doi":"10.52547/phypha.27.1.5","DOIUrl":"https://doi.org/10.52547/phypha.27.1.5","url":null,"abstract":"","PeriodicalId":20151,"journal":{"name":"Physiology and Pharmacology","volume":"121 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78420636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Arman Keymoradzadeh, Mojtaba Hedayati Ch, M. Abedinzade, Behrooz Khakpour Taleghani
{"title":"Enriched environment restores passive avoidance memory impairment in a rat model of neuroinflammation","authors":"Arman Keymoradzadeh, Mojtaba Hedayati Ch, M. Abedinzade, Behrooz Khakpour Taleghani","doi":"10.52547/phypha.26.3.4","DOIUrl":"https://doi.org/10.52547/phypha.26.3.4","url":null,"abstract":"","PeriodicalId":20151,"journal":{"name":"Physiology and Pharmacology","volume":"11 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87228789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Nayebi, A. Hashemian, H. Rezazadeh, M. Charkhpour, K. Fekri, Rasool Haddadi
Introduction: Cisplatin is an antineoplastic agent which is used in treatment of various cancers. However its clinical use is associated with oxidative stress-mediated neuropathic pain. This research aimed to explore the effect of silymarin on cisplatin-induced hyperalgesia (CIH) and oxidative stress biomarkers in male rats. Methods: Fifty-six male rats were allocated into seven equal groups. Hyperalgesia was caused by intraperitoneal single dose administration of cisplatin (1mg/kg) and assessed by utilizing tail-flick method. The impact of silymarin (25, 50 and 100 mg/kg/day for 15 days) on CIH was investigated on days 1, 5, 10 and 15. Blood samples were collected to assess malondialdehyde (MDA), glutathione peroxidase (GPx), superoxide dismutase (SOD) and total antioxidant status (TAS) on day fifteen. Results: Single dose injection of cisplatin (1mg/kg) could cause a significant hyperalgesia on days 5, 10 and 15. CIH was abolished by daily administration of silymarin (50 and 100mg/kg) on days 10 and 15. Serum MDA level was decreased in cisplatin and silymarin (100 mg/kg) co-treated rats, while there was an increase in GPx, SOD as well as TAS parameters. Conclusion: The results of this study revealed that silymarin prevents from CIH possibly by improving lipid peroxidation and oxidative stress biomarkers. Other clinical studies should be performed to establish possible use of silymarin for treatment of CIH in susceptible individuals.
{"title":"Silymarin reduced cisplatin-induced hyperalgesia bysuppressing oxidative stress in male rats","authors":"A. Nayebi, A. Hashemian, H. Rezazadeh, M. Charkhpour, K. Fekri, Rasool Haddadi","doi":"10.32598/PPJ.25.2.60","DOIUrl":"https://doi.org/10.32598/PPJ.25.2.60","url":null,"abstract":"Introduction: Cisplatin is an antineoplastic agent which is used in treatment of various cancers. However its clinical use is associated with oxidative stress-mediated neuropathic pain. This research aimed to explore the effect of silymarin on cisplatin-induced hyperalgesia (CIH) and oxidative stress biomarkers in male rats. Methods: Fifty-six male rats were allocated into seven equal groups. Hyperalgesia was caused by intraperitoneal single dose administration of cisplatin (1mg/kg) and assessed by utilizing tail-flick method. The impact of silymarin (25, 50 and 100 mg/kg/day for 15 days) on CIH was investigated on days 1, 5, 10 and 15. Blood samples were collected to assess malondialdehyde (MDA), glutathione peroxidase (GPx), superoxide dismutase (SOD) and total antioxidant status (TAS) on day fifteen. Results: Single dose injection of cisplatin (1mg/kg) could cause a significant hyperalgesia on days 5, 10 and 15. CIH was abolished by daily administration of silymarin (50 and 100mg/kg) on days 10 and 15. Serum MDA level was decreased in cisplatin and silymarin (100 mg/kg) co-treated rats, while there was an increase in GPx, SOD as well as TAS parameters. Conclusion: The results of this study revealed that silymarin prevents from CIH possibly by improving lipid peroxidation and oxidative stress biomarkers. Other clinical studies should be performed to establish possible use of silymarin for treatment of CIH in susceptible individuals.","PeriodicalId":20151,"journal":{"name":"Physiology and Pharmacology","volume":"198 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77442045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
O. Abiodun, A. Bakre, Christiana Adekoya, Adebola Kazeem, T. Oke, Tejumade S. Ujomu
{"title":"Naringin Ameliorates Cognitive Impairment in Streptozotocin/Nicotinamide Induced Type 2 Diabetes in Wistar Rats via inhibition of Inflammation and Acetylcholinesterase Activity","authors":"O. Abiodun, A. Bakre, Christiana Adekoya, Adebola Kazeem, T. Oke, Tejumade S. Ujomu","doi":"10.52547/phypha.26.1.10","DOIUrl":"https://doi.org/10.52547/phypha.26.1.10","url":null,"abstract":"","PeriodicalId":20151,"journal":{"name":"Physiology and Pharmacology","volume":"58 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90395185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. Emelike, U. Anyaehie, E. Iyare, C. Obike, C. Aloke, Ofovwe O. Ekakitie, J. Chukwu, N. Maduka, O. Chukwu
{"title":"EFFECT OF PRENATAL CONSUMPTION OF Combretum dolichopetalum BY PREGNANT RATS ON HAEMATOLOGICAL, BIOCHEMICAL PARAMETERS AND PREGNANCY OUTCOME","authors":"C. Emelike, U. Anyaehie, E. Iyare, C. Obike, C. Aloke, Ofovwe O. Ekakitie, J. Chukwu, N. Maduka, O. Chukwu","doi":"10.52547/phypha.27.1.1","DOIUrl":"https://doi.org/10.52547/phypha.27.1.1","url":null,"abstract":"","PeriodicalId":20151,"journal":{"name":"Physiology and Pharmacology","volume":"28 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83777804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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