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Effectiveness of Lipofilling in Postmastectomy Pain Syndrome: A Prospective Cohort Study. 脂质填充治疗乳房切除术后疼痛综合征的有效性:一项前瞻性队列研究。
IF 0.6 4区 医学 Q4 SURGERY Pub Date : 2025-09-29 DOI: 10.1177/22925503251379889
Victor Gibrán Reyes-García, Giancarlo Talleri-Ornelas, Giancarlo Talleri-De Andrea, Jesús Fernando Gallardo-Garcia, Quitzia Libertad Torres-Salazar

Background: Postmastectomy pain syndrome (PMPS) is a chronic condition affecting up to 50% of mastectomy patients, characterized by persistent pain that significantly impairs quality of life. Lipofilling, the transplantation of autologous fat, has emerged as a potential treatment option, offering pain relief and functional improvements through its regenerative properties. This study evaluates the effectiveness of lipofilling in managing PMPS and its impact on patients' quality of life. Methods: A prospective cohort study was conducted on 26 women diagnosed with PMPS at a tertiary care hospital in Jalisco, Mexico. This study exclusively included patients who had undergone modified radical mastectomy (MRM) without any form of breast reconstruction, in order to isolate non-implant-related causes of PMPS. Pain intensity and quality of life were assessed using the Visual Analog Scale (VAS) and EQ-5D-3L questionnaire at baseline, two weeks, and two months post-treatment. The lipofilling procedure included fat harvesting, processing via centrifugation, and reinjection into the affected chest wall areas. Changes in outcomes were analyzed using paired t-tests and Wilcoxon signed-rank tests, with significance set at p < 0.05. Results: The median VAS score decreased significantly from baseline (6, IQR 5-7) to two months post-treatment (4, IQR 3-5, p < 0.05). Quality of life scores improved markedly in the domains of mobility and usual activities (p < 0.05). No significant adverse effects were observed. Conclusion: Lipofilling is an effective intervention for reducing PMPS and improving quality of life, offering a promising option for reconstructive postmastectomy care.

背景:乳房切除术后疼痛综合征(PMPS)是一种慢性疾病,影响多达50%的乳房切除术患者,其特征是持续疼痛,严重影响生活质量。脂肪填充,自体脂肪的移植,已经成为一种潜在的治疗选择,通过其再生特性提供疼痛缓解和功能改善。本研究评估脂质填充治疗PMPS的有效性及其对患者生活质量的影响。方法:对26名在墨西哥哈利斯科州一家三级保健医院诊断为经前综合症的妇女进行前瞻性队列研究。本研究仅包括接受改良根治性乳房切除术(MRM)而没有任何形式的乳房重建的患者,以分离非植入物相关的PMPS原因。在治疗后基线、治疗后2周和2个月,采用视觉模拟量表(VAS)和EQ-5D-3L问卷对疼痛强度和生活质量进行评估。充脂过程包括脂肪收集,通过离心处理,再注射到受影响的胸壁区域。结果:VAS评分中位数从基线(6,IQR 5-7)到治疗后2个月(4,IQR 3-5, p)显著下降。结论:脂质填充是减少PMPS和改善生活质量的有效干预措施,为乳房切除术后重建护理提供了一个有希望的选择。
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引用次数: 0
Evaluating the Utility and Impact of Canadian Plastic Surgery Residency Programs' Instagram Accounts on Resident Recruitment and Engagement. 评估加拿大整形外科住院医师项目Instagram账户对住院医师招聘和参与的效用和影响。
IF 0.6 4区 医学 Q4 SURGERY Pub Date : 2025-09-29 DOI: 10.1177/22925503251379895
Chloe R Wong, Jacob Wise, Syena Moltaji, Heather L Baltzer, Jeffrey Fialkov

Introduction: This study assesses how Canadian Plastic Surgery Residency Instagram accounts are utilized and perceived by residents, fellows, and attending physicians, and evaluates their influence on medical students' residency program selection. Methods: This 2-part study includes: (1) a descriptive analysis of Instagram activity, content, and engagement, along with a national survey of Canadian plastic surgery residents, fellows, and attendings assessing account utility; and (2) a survey of medical students who attended the University of Toronto Plastic Surgery Residency Information Session, evaluating Instagram's influence on residency selection. Descriptive statistics were reported. Results: Twelve of 13 Canadian Plastic Surgery Residency Programs had active Instagram accounts. Canadian Plastic Surgery Residency Instagram accounts had an average of 119 posts (SD = 94) over 5 years (SD = 2). Among surveyed residents (N = 27/77, 35%) and fellows/attendings (N = 83/328, 25%), Instagram use was reported by 93% and 81%, respectively. Resident recruitment ranked as the top goal (residents 1.75, fellows/attendings 3.17), followed by achievement highlights. Most residents (80%) and fellows/attendings (53%) felt medical students benefitted most. Preferred content included program culture (85%, 84%), resident profiles (90%, 73%), and research highlights (70%, 70%). Among medical student respondents (N = 25/112, 22%), 95% followed Canadian programs on Instagram, seeking program culture, resident profiles, and educational opportunities (all 89%). Over half (56%) said Instagram influenced their perception of a program, with all reporting a positive impact. Conclusion: Instagram is a valuable platform for Canadian Plastic Surgery Residency Programs to share insights and influence medical student decision-making.

前言:本研究评估了加拿大整形外科住院医师Instagram账户如何被住院医师、研究员和主治医生使用和感知,并评估了它们对医学生住院医师项目选择的影响。方法:本研究分为两部分,包括:(1)对Instagram活动、内容和参与度进行描述性分析,并对加拿大整形外科住院医生、研究员和主治医生进行全国性调查,评估账户效用;(2)对参加多伦多大学整形外科住院医师信息会的医学生进行调查,评估Instagram对住院医师选择的影响。进行描述性统计。结果:13个加拿大整形外科住院医师项目中有12个有活跃的Instagram账户。加拿大整形外科住院医师的Instagram账户在5年(SD = 2)内平均有119条帖子(SD = 94)。在接受调查的住院医师(N = 27/77, 35%)和研究员/主治医师(N = 83/328, 25%)中,分别有93%和81%的人使用Instagram。住院医师招聘被列为最高目标(住院医师1.75人,研究员/主治医师3.17人),其次是成就亮点。大多数住院医生(80%)和研究员/主治医生(53%)认为医学生受益最多。首选内容包括项目文化(85%,84%),居民简介(90%,73%)和研究亮点(70%,70%)。在医学生受访者中(N = 25/112, 22%), 95%的人在Instagram上关注加拿大项目,寻求项目文化、住院医生简介和教育机会(均为89%)。超过一半(56%)的人表示,Instagram影响了他们对节目的看法,所有人都表示有积极的影响。结论:Instagram是加拿大整形外科住院医师项目分享见解和影响医学生决策的宝贵平台。
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引用次数: 0
An Anatomical Study of At-Risk Nerves During Carpal Tunnel Release: Considerations for the Prevention of Iatrogenic Nerve Injury. 腕管释放过程中危险神经的解剖学研究:预防医源性神经损伤的考虑。
IF 0.6 4区 医学 Q4 SURGERY Pub Date : 2025-09-25 DOI: 10.1177/22925503251379893
Max J Abercrombie, Kenneth Liu, Majid Alimohammadi

Introduction: Despite carpal tunnel release (CTR) being a common procedure in hand surgery, variation in the location of the nerves supplying the palm leads to a high risk of iatrogenic damage. Recommendations have been made for a surgical incision placement that would avoid such damage, yet injury persists in clinical practice. These studies infrequently consider the safety of multiple at-risk nerves when making their recommendation, often optimizing the safety of one and subsequently jeopardizing another's. Methods: Sixty-one dissections were performed on formalin preserved cadavers to define a safe zone in the palm and recommend an incision placement for CTR. Detailed measurements examining the anatomy of the palmar cutaneous branch of the median nerve (PCBMN), the palmar cutaneous branch of the ulnar nerve (PCBUN), and the thenar motor branch (TMB) were taken relative the scaphoid tubercle, pisiform, or the A line. Results: The PCBMN was located 3.3 ± 4.1 mm ulnar to the scaphoid tubercle and 8.7 ± 3.9 mm radial to the A line. The PCBUN was located the 6.5 ± 2.4 mm radial and 6.6 ± 3.7 mm ulnar from the pisiform and A line respectively. The TMB was found 8.0 ± 3.3 mm from the A line and was classified as 56% extraligamentous, 31% subligamentous, and 13% transligamentous. Conclusion: We conclude that an area approximately 6 mm ulnar and 7 mm radial from the A line is the safe zone for CTR and recommend an incision placement in line with the radial aspect of the fourth digit. This knowledge may aid surgeons performing CTR and help reduce iatrogenic damage.

导论:尽管腕管松解术(carpal tunnel release, CTR)是手部手术中常见的手术,但是掌部神经位置的变化会导致医源性损伤的高风险。建议手术切口放置,以避免这种损害,但损伤仍然存在于临床实践中。这些研究在提出建议时很少考虑多个高危神经的安全性,往往是优化一个神经的安全性,随后危及另一个神经的安全性。方法:对61例福尔马林保存的尸体进行解剖,以确定手掌的安全区,并推荐CTR的切口位置。相对于舟状骨结节、梨状骨或A线,对正中神经掌皮支(PCBMN)、尺神经掌皮支(PCBUN)和大鱼际运动支(TMB)进行了详细的解剖测量。结果:PCBMN位于舟状骨结节尺侧3.3±4.1 mm, A线桡侧8.7±3.9 mm。PCBUN分别位于距梨状骨6.5±2.4 mm桡侧和距A线6.6±3.7 mm尺侧。TMB位于距A线8.0±3.3 mm处,56%为韧带外区,31%为韧带下区,13%为韧带外区。结论:我们的结论是,距离A线约6mm尺侧和7mm桡侧的区域是CTR的安全区域,并建议切口放置在与第四指桡侧一致的位置。这些知识可以帮助外科医生进行CTR,并有助于减少医源性损伤。
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引用次数: 0
The Classification of Nerve Injury Revisited: Sunderland 0-VI. 神经损伤的分类:桑德兰0-VI。
IF 0.6 4区 医学 Q4 SURGERY Pub Date : 2025-09-16 DOI: 10.1177/22925503251375862
Stahs Pripotnev, Noah S Llaneras, Bob Teixeira, Erica Lee, Megan Patterson, Michelle Seu, Susan E Mackinnon

Introduction:Seddon and Sunderland's original nerve injury classification systems have stood the test of time over the last 70 years and continue to be widely used today. However, since those original descriptions, knowledge of nerve pathophysiology and healing has advanced, electrodiagnostic results have become more refined, and surgical options have increased. Methods: We offer a revisited review of the nerve injury classification to incorporate new knowledge for the modern era of nerve surgery. Results: We offer the addition of grades 0 and VI to the existing classification of nerve injuries based on Sunderland's framework, and we present a simplified classification that is patient and physician oriented, reflecting prognosis, time to recovery, and degree of recovery. Discussion: By following this nerve injury framework, clinicians can better assess, prognosticate, and manage patients.

引言:Seddon和Sunderland独创的神经损伤分类系统在过去70年里经受住了时间的考验,并在今天继续被广泛使用。然而,由于这些原始的描述,神经病理生理学和愈合的知识已经进步,电诊断结果变得更加精确,手术选择也增加了。方法:我们重新回顾神经损伤分类,为现代神经外科提供新的知识。结果:我们在现有的基于Sunderland框架的神经损伤分类基础上增加了0级和VI级,提出了一种以患者和医生为导向的简化分类,反映了预后、恢复时间和恢复程度。讨论:通过遵循这一神经损伤框架,临床医生可以更好地评估、预测和管理患者。
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引用次数: 0
Nipple Shield for Nipple Areolar Reconstruction: A Simple Technique. 乳头护罩用于乳头乳晕重建:一种简单的技术。
IF 0.6 4区 医学 Q4 SURGERY Pub Date : 2025-09-15 DOI: 10.1177/22925503251375854
Lucy Pu, Rawan ElAbd, Joshua Vorstenbosch
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引用次数: 0
Thoracic Outlet Syndrome After Implant-based Breast Reconstruction. 假体乳房重建术后的胸廓出口综合征。
IF 0.6 4区 医学 Q4 SURGERY Pub Date : 2025-09-08 DOI: 10.1177/22925503251371052
Idorenyin E Ndem, Grace Anne Longfellow, Christina N Kapsalis, Meredith A Kugar, Marcos Lopez, Lauren Cook, Nina Mehta, Jennifer Carr

Background: Thoracic outlet syndrome (TOS) is characterized by compression of neurovascular structures within the thoracic outlet. Symptoms include upper-extremity paresthesias, weakness, and, in some-cases, effort-induced thrombosis. Implant-based breast reconstruction has been identified as a potential etiology of TOS given the anatomic relationship of the pectoralis muscles to the thoracic outlet. This study aims to investigate the relationship between implant-based reconstruction and TOS diagnosis. Methods: A retrospective, single-institution review was conducted to identify female subjects that presented for evaluation of TOS-like symptoms between April 2014 and December 2022. Results: 319 female patients presented to our institution for evaluation. Sixteen (5.0%) of these subjects previously underwent implant-based breast reconstruction, for which the following outcomes were considered: symptom type, timing to onset of symptoms relative to timing of reconstruction, and diagnosis of TOS as confirmed by imaging or testing. Seven of 16 patients (43.8%) received a formal diagnosis of TOS from a surgical specialist and were also found to have subpectoral implants. Conclusions: Based on clinical evidence, breast reconstruction has been acknowledged as a probable etiology for TOS. However, over half of symptomatic subjects did not receive a formal diagnosis of TOS, suggesting a potential for improvement in screening methods for this population. While the data of this study suggests that the plane of reconstruction, specifically subpectoral, could have an association with TOS, further research with a larger patient cohort is necessary to establish a definitive causal relationship.

背景:胸廓出口综合征(TOS)以胸廓出口神经血管结构受压为特征。症状包括上肢感觉异常、虚弱,在某些情况下,还包括努力引起的血栓形成。鉴于胸肌与胸廓出口的解剖关系,植体乳房重建术已被确定为TOS的潜在病因。本研究旨在探讨植体重建与TOS诊断的关系。方法:对2014年4月至2022年12月期间提出tos样症状评估的女性受试者进行回顾性、单机构评价。结果:319例女性患者来我院评估。其中16例(5.0%)曾接受过基于假体的乳房重建,考虑了以下结果:症状类型、相对于重建时间的症状发作时间以及通过影像学或检查确诊TOS的诊断。16名患者中有7名(43.8%)接受了外科专家对TOS的正式诊断,并发现有胸下植入物。结论:基于临床证据,乳房重建已被认为是TOS的可能病因。然而,超过一半的有症状的受试者没有得到正式的TOS诊断,这表明对这一人群的筛查方法有改进的潜力。虽然本研究的数据表明,重建平面,特别是胸下,可能与TOS有关,但需要对更大的患者群体进行进一步的研究,以建立明确的因果关系。
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引用次数: 0
Emergency Department Visits Within 90 Days of Elective Hand Surgery: A Healthcare Utilization Study. 选择性手外科90天内急诊就诊:一项医疗保健利用研究。
IF 0.6 4区 医学 Q4 SURGERY Pub Date : 2025-09-03 DOI: 10.1177/22925503251371057
Katie Ross, Haley Glazebrook, Jo-Anne Douglas, Justin MacLellan, Emily M Krauss

Introduction: Emergency department (ED) visits following elective surgeries place significant strain on already overburdened healthcare systems. In Nova Scotia, carpal tunnel release (CTR) and trigger finger release (TFR) are the most common elective hand surgeries performed. This study sought to determine the rates, reasons, and risk factors associated with ED visits following elective outpatient hand surgery. Methods: Patients who underwent CTR or TFR between April 1, 2016 and March 31, 2022, and visited any Nova Scotia ED within 90 days of surgery were identified using provincial healthcare databases. A chart review was completed to explore ED timing, reasons for presentation, and predetermined systems-level factors. Results: During the retrospective period, 2690 patients underwent CTR and 1103 patients underwent TFR. For CTR, 159 patients (5.97%) presented to the ED within 90 days of surgery for surgery-specific concerns. The most common presentation was surgical site infection (2.16%), wound check (1.60%), and suture removal (1.04%). For TFR, 63 (5.71%) patients presented to the ED within 90 days. Similarly, surgical site infection was the most common presentation (2.63%) followed by suture removal (1.45%) and wound check (1.18%). The most frequent timing for ED presentation was days 13-15 (27.9%). Conclusion: In an evaluation of true healthcare utilization after elective surgery, ED visits for surgery-specific concerns after CTR and TFR were nearly 6%, far exceeding expected complication rates. As the presentations are manageable in an outpatient clinic or office setting, a mixed-methods patient-oriented intervention is planned to redirect this population away from the ED.

简介:急诊部门(ED)访问后的选择性手术给已经不堪重负的医疗保健系统带来了巨大的压力。在新斯科舍省,腕管松解术(CTR)和扳机指松解术(TFR)是最常见的手部手术。本研究旨在确定选择性门诊手部手术后急诊科就诊的发生率、原因和危险因素。方法:在2016年4月1日至2022年3月31日期间接受CTR或TFR的患者,并在手术后90天内前往新斯科舍省任何急诊科就诊,并使用省级卫生保健数据库进行识别。完成了图表审查,以探索ED的时间,演示的原因和预定的系统级因素。结果:在回顾性研究期间,2690例患者行CTR, 1103例患者行TFR。对于CTR, 159例患者(5.97%)在手术后90天内因手术特异性问题就诊于急诊科。最常见的表现是手术部位感染(2.16%)、伤口检查(1.60%)和缝线拆除(1.04%)。对于TFR, 63例(5.71%)患者在90天内就诊。同样,手术部位感染是最常见的表现(2.63%),其次是拆线(1.45%)和伤口检查(1.18%)。最常见的ED出现时间是第13-15天(27.9%)。结论:在择期手术后真实医疗保健利用的评估中,CTR和TFR后因手术特定问题而去急诊室就诊的比例接近6%,远远超过预期的并发症发生率。由于在门诊诊所或办公室环境中进行演示是可管理的,因此计划采用以患者为导向的混合方法干预,将这些人群从急诊科转移出去。
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引用次数: 0
Acquired Brown Syndrome as a Postoperative Complication of Orbital Wall Fracture Repair with Metallic Mesh. 金属网修复眶壁骨折术后并发症获得性布朗综合征。
IF 0.6 4区 医学 Q4 SURGERY Pub Date : 2025-08-29 DOI: 10.1177/22925503251371048
Justin J Lee, Nikhil Patil, Trent Schimmel, Matthew D Benson, Joshua J DeSerres

Background: Surgical repair of orbital fractures comes with risks. One rare risk is interference with the actions of the superior oblique tendon-muscle complex causing an acquired Brown syndrome. We present the case of a 45-year-old man who developed acquired Brown syndrome after undergoing repair of a large orbital floor and medial orbital wall fracture using a titanium mesh implant. A case report was prepared to discuss a rare surgical risk with open reduction internal fixation (ORIF) of an orbital wall fracture. Methods: A retrospective chart review was performed. Results: Post-operative ophthalmological assessment revealed persistent diplopia along with limitations of up-gaze particularly in the adducted position. Ultimately, the patient underwent surgical repositioning of the orbital implant, which seemingly released the superior oblique muscle-tendon complex, resolving most of the diplopia. No further treatment with prisms or strabismus surgery has been required. Conclusions: Acquired Brown syndrome is a potential risk of surgical repair of orbital fractures involving the medial orbital wall. Herein this case study, we describe a case of acquired Brown syndrome following ORIF of an orbital floor and medial wall fracture, which was alleviated with a revision surgery.

背景:眼眶骨折的手术修复是有风险的。一种罕见的风险是干扰上斜肌腱-肌肉复合体的活动,导致获得性布朗综合征。我们报告一例45岁的男性患者,在使用钛网植入物修复大面积眶底和眶内壁骨折后出现获得性布朗综合征。本文报告一例罕见的眶壁骨折切开复位内固定(ORIF)手术风险。方法:回顾性图表回顾。结果:术后眼科检查发现持续性复视伴上视限制,尤其是内收位。最终,患者接受了眶内植入物的手术重新定位,似乎释放了上斜肌-肌腱复合体,解决了大部分复视。不需要进一步的棱镜治疗或斜视手术。结论:获得性布朗综合征是手术修复累及眶内壁骨折的潜在危险因素。在此病例研究中,我们描述了一例眶底和内侧壁骨折ORIF后获得性布朗综合征,该病例通过翻修手术得到缓解。
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引用次数: 0
Publication Trajectories of Today's Canadian Academic Plastic Surgeons: A Bibliometric Analysis. 今天加拿大学术整形外科医生的出版轨迹:文献计量分析。
IF 0.6 4区 医学 Q4 SURGERY Pub Date : 2025-08-29 DOI: 10.1177/22925503251371051
Norbert Banyi, Theresa Buchel, Young Ji Tuen, Sophia Shayan, Rebecca Courtemanche, Jugpal S Arneja

Introduction: The landscape of academic research has evolved notably in recent decades, shifting towards earlier career publications and more interdisciplinary collaborations. This study aims to identify research productivity trends among Canadian academic plastic surgeons. Methods: The Web of Science and MEDLINE databases were searched by plastic surgeon names and for each result, the author list position, year of publication, journal, and citation counts were collected. Surgeons' demographics, including gender and medical school graduation year, were obtained from provincial college websites. Publication rates over a plastic surgeon's career trajectory were analyzed by surgeons' current decade of practice. Results: There were 3661 included entries in our database, corresponding to 2831 unique publications by 245 surgeons (71%, 175/245 men). The median year of medical school graduation was 2002 (SD 12 years). Surgeons in more recent decades of practice (decade 1 or decade 2) published earlier and more frequently per career decade. A wide distribution of publication rates (range 0-66) was found for surgeons currently in their fourth decade of practice. From 2005 to 2020, the number of publications per year increased dramatically, from 36 publications in 2005 to 198 publications in 2020. Citations normalized by years from publication remained stable. The proportion of first authorship decreased from 0.63 and 0.42 in the pre-medicine and educational decades, to 0.09 and 0.08 by the third and fourth decades of practice (p < .001). Conclusion: An emerging trend of earlier and increased publications among newer generations of surgeons was seen. Incentives to participate and mentor in research for surgeons gaining seniority are suggested.

引言:近几十年来,学术研究的格局发生了显著的变化,转向早期的职业出版物和更多的跨学科合作。本研究旨在确定加拿大学术整形外科医生的研究生产力趋势。方法:通过Web of Science和MEDLINE数据库检索整形外科医生的姓名,并收集每个结果的作者名单位置、发表年份、期刊和被引次数。外科医生的人口统计数据,包括性别和医学院毕业年份,从省级高校网站获得。在整形外科医生的职业生涯轨迹中,发表率是根据外科医生目前十年的实践来分析的。结果:我们的数据库中有3661条纳入条目,对应245名外科医生的2831篇独特出版物(71%,175/245名男性)。医学院毕业年份中位数为2002年(标准差12年)。外科医生在近几十年的实践中(第1年或第2年)每十年发表的时间更早,频率更高。发表率分布广泛(范围0-66)的外科医生目前在他们的执业第四个十年。从2005年到2020年,每年的出版物数量急剧增加,从2005年的36篇增加到2020年的198篇。从出版开始按年份标准化的引文保持稳定。第一作者比例从医学预科和教育十年的0.63和0.42下降到第三和第四个十年的0.09和0.08 (p结论:在新一代外科医生中出现了早期和增加发表论文的趋势。建议为获得资历的外科医生提供参与和指导研究的激励措施。
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引用次数: 0
Breast Cancer Local Recurrence in Patients With and Without Post-Mastectomy Immediate Breast Reconstruction: Systematic Review and Meta-Analysis. 乳腺癌局部复发患者在乳房切除术后立即乳房重建:系统回顾和荟萃分析。
IF 0.6 4区 医学 Q4 SURGERY Pub Date : 2025-08-26 DOI: 10.1177/22925503251363108
Melissa Chao, Kellan Woo, David Long, Dana Toameh, Kathryn V Isaac

Introduction: Despite rising rates of post-mastectomy immediate breast reconstruction (IBR), there are fears of local recurrence (LR) among patients and physicians. This systematic review and meta-analysis compare long-term LR incidence in patients with mastectomy and IBR (Mast + IBR) to patients with mastectomy alone (Mast - IBR). Methods: Medline, Embase, and Web of Science databases were searched for relevant articles. Articles published between January 2000 and December 2020 were included when LR rates were reported for patients with breast cancer (stage I or II) who underwent mastectomy with or without IBR. A random-effects model was used to calculate pooled odds ratios (ORs) with a 95% confidence interval (CI), adjusted for age, and follow-up time. Results: In total, 1475 unique articles were identified, with 1434 excluded in title abstract screening and 31 excluded in full-text screening. Ten articles, amounting to 15 173 patients (3478 Mast + IBR, 11 695 Mast - IBR), were included. In total, 111 (3.2%) patients in Mast + IBR experienced LR after a mean follow-up time of 72.9 months, while 245 (2.1%) in Mast - IBR experienced LR after a mean follow-up time of 73.3 months. There were no increased odds of LR in Mast + IBR, adjusted for age, and follow-up time (OR 1.17, CI 0.86-1.59, P = 0.59). Conclusion: This meta-analysis supports that IBR is not associated with increased LR odds compared to mastectomy alone. Patients with breast cancer may undergo mastectomy and IBR without concern of increased rates of LR, which contributes to improved quality of life.

导语:尽管乳房切除术后立即乳房重建(IBR)的比例不断上升,但患者和医生仍然担心局部复发(LR)。本系统综述和荟萃分析比较了乳房切除术和IBR患者(Mast + IBR)和单独乳房切除术患者(Mast - IBR)的长期LR发病率。方法:检索Medline、Embase和Web of Science数据库的相关文章。2000年1月至2020年12月期间发表的文章被纳入了有或没有IBR的乳房切除术的乳腺癌(I期或II期)患者的LR率报告。使用随机效应模型计算合并优势比(or), 95%置信区间(CI),调整年龄和随访时间。结果:共鉴定出1475篇独特的文章,其中1434篇被排除在标题摘要筛选之外,31篇被排除在全文筛选之外。纳入10篇文章,共15173例患者(3478例Mast + IBR, 11695例Mast - IBR)。总体而言,111例(3.2%)Mast + IBR患者在平均随访时间为72.9个月后出现LR,而245例(2.1%)Mast - IBR患者在平均随访时间为73.3个月后出现LR。经年龄和随访时间调整后,Mast + IBR患者发生LR的几率没有增加(OR 1.17, CI 0.86-1.59, P = 0.59)。结论:这一荟萃分析支持IBR与单纯乳房切除术相比与LR风险增加无关。乳腺癌患者可以接受乳房切除术和IBR,而不必担心LR的发生率增加,这有助于提高生活质量。
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