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Contemporary Approaches to Peripheral Nerve Surgery. 周围神经外科的现代方法
IF 0.7 4区 医学 Q4 SURGERY Pub Date : 2024-08-01 Epub Date: 2022-09-09 DOI: 10.1177/22925503221120571
Christopher Doherty, Erin Brown, Michael Berger, Alexander Seal, David Tang, Rowan Chandler, Sean Bristol

"State of the Art" Learning Objectives: This manuscript serves to provide the reader with a general overview of the contemporary approaches to peripheral nerve reconstruction as the field has undergone considerable advancement over the last 3 decades. The learning objectives are as follows: To provide the reader with a brief history of peripheral nerve surgery and some of the landmark developments that allow for current peripheral nerve care practices.To outline the considerations and management options for the care of patients with brachial plexopathy, spinal cord injury, and lower extremity peripheral nerve injury.Highlight contemporary surgical techniques to address terminal neuroma and phantom limb pain.Review progressive and future procedures in peripheral nerve care, such as supercharge end-to-side nerve transfers.Discuss rehabilitation techniques for peripheral nerve care.

“最新技术”学习目标:这篇手稿旨在为读者提供一个关于周围神经重建的当代方法的概述,因为该领域在过去30年中取得了长足的进步。学习目标如下:为读者提供外周神经手术的简史,以及允许当前外周神经护理实践的一些里程碑式的发展。概述臂丛病、脊髓损伤和下肢周围神经损伤患者的护理注意事项和管理选择。强调当代外科技术,以解决晚期神经瘤和幻肢疼痛。回顾外周神经护理的进展和未来程序,如超负荷端侧神经转移。讨论周围神经护理的康复技术。
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引用次数: 0
Comparison of Surgical Wait Times and Procedure Length in the Management of Postaxial Polydactyly Using Local or General Anesthesia. 局部或全身麻醉治疗轴后多指畸形的手术等待时间和手术时间的比较
IF 0.7 4区 医学 Q4 SURGERY Pub Date : 2024-08-01 Epub Date: 2022-11-17 DOI: 10.1177/22925503221134813
Adam Mosa, Mithila Somasundaram, Diba Vahidi Ferdosi, Kristen Davidge, Howard M Clarke, Emily S Ho, Terence Kwan-Wong

Introduction: For infants with ulnar polydactyly, surgical removal of the supernumerary digit can be performed under general or local anesthetic. This study evaluated the wait times, surgical duration, and sedation times associated with performing the procedure under local versus general anesthetic in infants with ulnar polydactyly. Methods: The databases of three surgeons at our institution were reviewed for children less than 2 years of age who underwent surgery for non-syndromic ulnar polydactyly. Data collection included patient demographics, wait times, duration of surgery and sedation and complications. Results: The study included children (n  =  55) who received treatment under local (n  =  22) or general (n  =  33) anesthesia. The wait times for the local anesthetic group were significantly shorter than the general anesthetic group (p < 0.05) for: referral to first consultation appointment; referral to surgery date, and decision date to surgery date. The duration of surgery (17.9  ±  6.9 vs 36.6  ±  20.2 min) and sedation time (26.3  ±  11.1 vs 74.8  ±  29.1 min) were significantly shorter in the local anaesthetic group (p < 0.05). There were no differences in complication rates between the groups. Conclusion: In this single-institution retrospective analysis, treatment of non-syndromic ulnar polydactyly with local anesthetic and bottle sedation was associated with shorter wait times, and duration of surgery and sedation. Level of Evidence: III, retrospective chart review and quality improvement initiative.

引言:对于患有尺侧多指畸形的婴儿,手术切除多指可以在全身或局部麻醉下进行。本研究评估了尺骨多指畸形婴儿在局部和全身麻醉下进行手术的等待时间、手术持续时间和镇静时间。方法:回顾了我院三名外科医生的数据库,这些外科医生都是2岁以下接受非综合征尺骨多指畸形手术的儿童。数据收集包括患者人口统计、等待时间、手术持续时间、镇静和并发症。结果:研究包括儿童(n  =  55)接受局部(n  =  22)或一般(n  =  33)麻醉。局部麻醉组的等待时间明显短于全身麻醉组(p < 0.05)用于:转诊至首次会诊预约;手术日期的转诊以及手术日期的决定日期。手术持续时间(17.9  ±  6.9对36.6  ±  20.2分钟)和镇静时间(26.3  ±  11.1对74.8  ±  29.1分钟)明显缩短(p < 0.05)。两组并发症发生率无差异。结论:在这项单一机构的回顾性分析中,局部麻醉和瓶镇静治疗非综合征尺侧多指畸形与更短的等待时间、手术和镇静时间有关。证据级别:III,回顾性图表审查和质量改进倡议
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引用次数: 0
Commentary: Analysis of Advanced Degrees in Academic Plastic Surgery Faculty. 邀请讨论:学术整形外科学院高级学位分析
IF 0.7 4区 医学 Q4 SURGERY Pub Date : 2024-08-01 Epub Date: 2023-05-17 DOI: 10.1177/22925503231172793
Subhas Gupta
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引用次数: 0
The Financial Considerations of Employing a Dedicated Chaperone in Clinical Practice. 在临床实践中雇用专职监护人的财务考虑
IF 0.7 4区 医学 Q4 SURGERY Pub Date : 2024-08-01 Epub Date: 2022-10-30 DOI: 10.1177/22925503221128988
Nick N Maizlin, Stephanie Black, Olubimpe Ayeni

Introduction: Medical associations and medicolegal bodies are urging for increased chaperone use by physicians during intimate physical examinations in clinical practice (such as breast or pelvic examinations). However, widespread chaperone use is limited by factors such as staff availability and financial considerations. Presently, there is a scarcity of information available regarding the cost of hiring a dedicated chaperone. This study investigates the cost of hiring a chaperone and its financial implications for a physician's clinical practice. Materials and Methods: Using data from the Government of Canada website, the range of salary rates for clinic staff who can act as a chaperone in Canada was analyzed. The cost of hiring a chaperone was estimated to be in the range between the cost of hiring a minimum-wage worker and a nurse (the highest-paid hired medical office staff). Obstetrics and Gynecology as well as Plastic Surgery urban community practices were consulted regarding the costs of operating a clinic. Results: The approximate annual income for a minimum-wage worker in Canada is $29,250 CAD. Registered nurses earn on average $72,783.75 CAD per year. The cost of operating a private clinic practice with one staff member in Canada is on average $102,500 CAD per year. Thus, hiring an additional full-time chaperone could increase clinic expenses by approximately 49% per year, bringing the clinic cost to approximately $153,517 CAD per year. For part-time employment, the annual cost of hiring a chaperone is approximately $10,203 CAD for each day/week of employment. Conclusion: In terms of financial considerations, hiring a chaperone can increase clinic expenses by approximately one-and-a-half times. The findings of this study provide an important reference for physicians and may assist with the decision to employ chaperones in clinical practice.

引言:医学协会和法医机构敦促医生在临床实践中的亲密体检(如乳房或骨盆检查)中增加伴侣的使用。然而,广泛使用伴侣受到工作人员可用性和财务考虑等因素的限制。目前,关于聘请一名专职监护人的费用,信息匮乏。这项研究调查了聘请监护人的成本及其对医生临床实践的财务影响。材料和方法:使用加拿大政府网站上的数据,分析了在加拿大可以担任监护人的诊所工作人员的工资率范围。据估计,雇佣监护人的成本在雇佣一名最低工资工人和一名护士(薪酬最高的医务室员工)的成本之间。就诊所的运营成本咨询了妇产科和整形外科城市社区实践。结果:加拿大最低工资工人的年收入约为29250加元。注册护士的平均年收入为72783.75加元。在加拿大,由一名工作人员经营一家私人诊所的费用平均每年为102500加元。因此,雇佣一名额外的全职监护人每年可能会使诊所费用增加约49%,使诊所费用达到每年约153517加元。对于非全日制工作,雇佣监护人的年费用约为10203加元,每工作一天/周。结论:从经济角度考虑,聘请陪护可以使诊所费用增加约1.5倍。这项研究的结果为医生提供了重要的参考,并可能有助于在临床实践中使用监护人的决定。
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引用次数: 0
Prevalence and Severity of Chronic Pain in Patients Receiving Mastectomy with Alloplastic Immediate Breast Reconstruction: A Survey Study. 接受乳房切除术并同种异体即刻乳房重建的患者慢性疼痛的患病率和严重程度:一项调查研究
IF 0.7 4区 医学 Q4 SURGERY Pub Date : 2024-08-01 Epub Date: 2022-10-19 DOI: 10.1177/22925503221128985
Larissa Rogowsky, Caroline F Illmann, Sheina A Macadam, Peter A Lennox, Nancy Van Laeken, Esta S Bovill, Christopher Doherty, Kathryn V Isaac

Introduction: Breast cancer is the most frequently diagnosed cancer worldwide. For those undergoing mastectomy, the choice of alloplastic immediate breast reconstruction (IBR) is increasingly favored. Post-operative chronic pain is an important consideration in this decision, but there is a paucity of data for those undergoing alloplastic IBR. We sought to examine the prevalence, severity, and risk factors for the development of chronic pain in this cohort using validated patient-reported outcome measures. Methods: A cross-sectional survey study was conducted among patients receiving mastectomy with alloplastic IBR. Participants completed 3 surveys querying chronic pain, specifically the Breast Cancer Pain Questionnaire (BCPQ), Brief Pain Inventory (BPI), and BREAST-Q. Participant medical records were reviewed for demographic and surgical variables. Results: A total of 118 patients participated in the study-a response rate of 33.6%. Chronic pain prevalence was high (52.5%), and only 29.0% of these patients had consulted a physician regarding their pain. Among those reporting chronic pain (n = 62), the median severity of pain was 3.1 on an 11-point scale. Chronic pain was associated with radiation (p = .018), bilateral reconstruction (p = .05), worse emotional health (p = .0003), less self (p = .022), and sexual confidence (p = .044). Inter-tool reliability was high, with no significant difference in responses between the 3 surveys. Conclusion: In this cohort, chronic pain is supported as a significant concern among patients who have undergone mastectomy with alloplastic IBR. Given the burden of chronic pain, there is an opportunity to intervene with preventative measures and support for its management.

乳腺癌是世界上最常见的癌症。对于接受乳房切除术的患者,选择同种异体即刻乳房重建(IBR)越来越受到青睐。术后慢性疼痛是这一决定的重要考虑因素,但缺乏同种异体IBR患者的数据。我们试图使用经过验证的患者报告的结果测量来检查该队列中慢性疼痛的患病率、严重程度和发展的危险因素。方法:对接受同种异体乳房切除术的患者进行横断面调查研究。参与者完成了3项关于慢性疼痛的调查,特别是乳腺癌疼痛问卷(BCPQ)、简短疼痛量表(BPI)和Breast - q。对参与者的医疗记录进行了人口统计学和外科变量的审查。结果:共118例患者参与研究,有效率为33.6%。慢性疼痛的患病率很高(52.5%),只有29.0%的患者就他们的疼痛咨询过医生。在报告慢性疼痛的患者中(n = 62),疼痛严重程度中位数为3.1(11分制)。慢性疼痛与放射(p = 0.018)、双侧重建(p = 0.05)、较差的情绪健康(p = 0.0003)、较差的自我(p = 0.022)和性自信(p = 0.044)有关。工具间的可靠性很高,3个调查之间的反应没有显著差异。结论:在这个队列中,慢性疼痛是接受同种异体乳房切除术的患者的一个重要问题。鉴于慢性疼痛的负担,有机会干预预防措施和支持其管理。
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引用次数: 0
Commentary: Trends and Early Complications in Direct-to-Implant Breast Reconstruction: An Updated Analysis of the ACS-NSQIP Database. 受邀讨论:直接植入乳房重建的趋势和早期并发症:ACS-NSQIP数据库的更新分析
IF 0.7 4区 医学 Q4 SURGERY Pub Date : 2024-08-01 Epub Date: 2023-03-13 DOI: 10.1177/22925503231163243
Mitchell H Brown
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引用次数: 0
Analysis of Additional Degrees in Academic Plastic Surgery Faculty. 学术整形外科学院增设学位的分析
IF 0.7 4区 医学 Q4 SURGERY Pub Date : 2024-08-01 Epub Date: 2022-12-19 DOI: 10.1177/22925503221144039
Sahil Chawla, Sarim Faheem, Michael L Moreton, Amardeep Sekhon, Orapin M Amornteerasawas, Jeffrey Ding, Faisal Khosa

Background: As plastic surgery continues to evolve, an increasing number of surgeons are attaining additional degrees (ADs). Prior studies illustrate this trend of increased AD attainment among plastic surgery faculty within the United States. Yet, no such study has documented AD attainment variability and influence within Canadian plastic surgery faculty. Objectives: Our objective was to investigate the relationship between AD attainment and gender, alongside research productivity, and academic rank of Canadian plastic surgery faculty members. Methods: All Canadian academic plastic surgery faculty members were identified and information regarding gender, academic rank, research productivity, timing of AD attainment was recorded. AD was defined as any degree beyond a medical degree or equivalent. Results: A total of 299 faculty members were identified. Of these, 33% (N = 99) attained an AD. A higher percentage of females (40%) obtained ADs compared to males (30%) (P = .0402). When controlling for number of years in practice, there was a significantly larger proportion of females than males with ADs as assistant and associate professor (P = .033). Faculty with ADs were associated with higher research productivity and higher academic rank than those with MDs (P < .05). ADs were commonly obtained post-residency (38%) and most common ADs were MSc (51%) and PhDs (21%). It was found that the Canadian plastic surgeons were less likely to pursue MBAs than US plastic surgeons (P = .002). Conclusion: One-third of Canadian academic plastic surgeons had ADs. Those with ADs present with higher research productivity and academic rank. When segmented by gender, there were significant differences among AD holders. The results of this study will lend support to ongoing endeavors voicing the need for gender equity in academic plastic surgery.

背景:随着整形外科的不断发展,越来越多的外科医生获得了额外的学位(ad)。先前的研究表明,在美国整形外科教师中,AD的实现有增加的趋势。然而,在加拿大整形外科教师中,没有这样的研究记录了AD成就的变异性和影响。目的:我们的目的是调查AD成就与性别之间的关系,以及研究生产力和加拿大整形外科教师的学术等级。方法:对所有加拿大学术整形外科教师进行调查,记录性别、学术等级、研究成果、AD实现时间等信息。AD被定义为医学学位或同等学历以外的任何学位。结果:共确定了299名教职员工。其中33% (N = 99)达到AD。与男性(30%)相比,女性(40%)获得ad的比例更高(P = 0.0402)。在控制实习年数的情况下,ADs担任助理、副教授的女性比例显著高于男性(P = 0.033)。与md教员相比,ad教员具有更高的研究效率和更高的学术排名(P < 0.05)。通常在实习后获得ADs(38%),最常见的ADs是硕士(51%)和博士(21%)。研究发现,与美国整形外科医生相比,加拿大整形外科医生攻读mba学位的可能性较小(P = 0.002)。结论:加拿大三分之一的学术整形外科医生患有ad,患有ad的人具有更高的研究效率和学术排名。当按性别细分时,AD持有者之间存在显著差异。这项研究的结果将为呼吁学术整形手术中性别平等的持续努力提供支持。
{"title":"Analysis of Additional Degrees in Academic Plastic Surgery Faculty.","authors":"Sahil Chawla, Sarim Faheem, Michael L Moreton, Amardeep Sekhon, Orapin M Amornteerasawas, Jeffrey Ding, Faisal Khosa","doi":"10.1177/22925503221144039","DOIUrl":"10.1177/22925503221144039","url":null,"abstract":"<p><p><b>Background:</b> As plastic surgery continues to evolve, an increasing number of surgeons are attaining additional degrees (ADs). Prior studies illustrate this trend of increased AD attainment among plastic surgery faculty within the United States. Yet, no such study has documented AD attainment variability and influence within Canadian plastic surgery faculty. <b>Objectives:</b> Our objective was to investigate the relationship between AD attainment and gender, alongside research productivity, and academic rank of Canadian plastic surgery faculty members. <b>Methods:</b> All Canadian academic plastic surgery faculty members were identified and information regarding gender, academic rank, research productivity, timing of AD attainment was recorded. AD was defined as any degree beyond a medical degree or equivalent. <b>Results:</b> A total of 299 faculty members were identified. Of these, 33% (N = 99) attained an AD. A higher percentage of females (40%) obtained ADs compared to males (30%) (<i>P</i> = .0402). When controlling for number of years in practice, there was a significantly larger proportion of females than males with ADs as assistant and associate professor (<i>P</i> = .033). Faculty with ADs were associated with higher research productivity and higher academic rank than those with MDs (<i>P</i> < .05). ADs were commonly obtained post-residency (38%) and most common ADs were MSc (51%) and PhDs (21%). It was found that the Canadian plastic surgeons were less likely to pursue MBAs than US plastic surgeons (<i>P</i> = .002). <b>Conclusion:</b> One-third of Canadian academic plastic surgeons had ADs. Those with ADs present with higher research productivity and academic rank. When segmented by gender, there were significant differences among AD holders. The results of this study will lend support to ongoing endeavors voicing the need for gender equity in academic plastic surgery.</p>","PeriodicalId":20206,"journal":{"name":"Plastic surgery","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11298144/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47123291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Extending the Indications for Direct Transcutaneous Lower Blepharoplasty With an Infraorbital Incision to Tear Trough Deformities, Suborbicularis Oculi Fat, Festoons, and Revision Blepharoplasty. 眶下切口直接经皮下睑成形术的适应症扩展到撕裂槽畸形、眼轮匝肌下脂肪、赘肉和改型睑成形术
IF 0.7 4区 医学 Q4 SURGERY Pub Date : 2024-08-01 Epub Date: 2022-08-24 DOI: 10.1177/22925503221120545
Ulrich E Ziegler, Ruth C Schäfer, Adrien Daigeler, Philip H Zeplin

Introduction: Treatment of high-grade lower eyelid deformities with massive skin laxity and retroseptal fat pads can be challenging. Common techniques such as the transconjunctival approach and transcutaneous technique performed through a subciliary incision are associated with increased complication rates. Direct excision of the lower eyelid through an infraorbital incision is an alternative technique that allows safe treatment of dermatochalasis and pigmentation and correction of tear trough deformities, suborbicularis oculi fat, and festoons. This study aimed to determine whether direct transcutaneous blepharoplasty with an infraorbital incision could be indicated for these conditions instead of the established operative methods. Methods: A retrospective study of 21 patients with Fratila grades 9 or 10, Hirmand grade 3, and Barton grade 3 who underwent direct transcutaneous lower eyelid blepharoplasty via an infraorbital incision under local anesthesia was performed. All patients underwent surgery during a 9-year period from January 2010 to December 2018. The follow-up period was 12 months. Results were rated postoperatively using Barton grading. Results: Of 21 consecutive patients (13 women and 8 men), 18 required retroseptal fat pad removal, 3 had laxity of the skin and orbicularis muscle, and 5 had triangular cheek festoons. Combined lower and upper blepharoplasty was performed for 12 patients. All patients were satisfied with their surgical results and major improvements were observed. Scar quality was considered good by all patients. Conclusion: Direct transcutaneous lower blepharoplasty of the orbital rim can be indicated for different tear trough deformities, suborbicularis oculi fat laxity, and festoons.

引言:治疗伴有大量皮肤松弛和隔后脂肪垫的高级下眼睑畸形可能具有挑战性。常见的技术,如经结膜入路和通过髂下切口进行的经皮技术,会增加并发症发生率。通过眶下切口直接切除下眼睑是一种替代技术,可以安全地治疗皮肤松弛症和色素沉着,并矫正泪沟畸形、眼轮匝肌下脂肪和节索。本研究旨在确定眶下切口直接经皮眼睑整形术是否适用于这些情况,而不是既定的手术方法。方法:对21例Fratila 9级或10级、Hirmand 3级和Barton 3级患者进行回顾性研究,这些患者在局部麻醉下通过眶下切口进行了直接经皮下眼睑整形术。所有患者在2010年1月至2018年12月的9年时间里接受了手术。随访12个月。术后采用Barton分级对结果进行评分。结果:在21名连续患者中(13名女性和8名男性),18名患者需要去除间隔后脂肪垫,3名患者皮肤和轮匝肌松弛,5名患者脸颊呈三角形。对12例患者进行了上下眼睑联合整形术。所有患者都对他们的手术结果感到满意,并观察到明显的改善。所有患者都认为疤痕质量良好。结论:直接经皮眶缘下睑成形术可用于不同类型的泪沟畸形、眼轮匝下脂肪松弛和眼睑下垂。
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引用次数: 0
Trends and Early Complications in Direct-to-Implant Breast Reconstruction: An Updated Analysis of the ACS-NSQIP Database. 直接植入乳房重建的趋势和早期并发症:ACS-NSQIP数据库的最新分析
IF 0.7 4区 医学 Q4 SURGERY Pub Date : 2024-08-01 Epub Date: 2022-12-13 DOI: 10.1177/22925503221141708
Ethan L Plotsker, Robyn N Rubenstein, Francis D Graziano, Kathryn Haglich, Joseph J Disa, Carrie S Stern, Jonas A Nelson

Background: Rates of direct-to-implant (DTI) breast reconstruction, in which breast implants are placed at the time of mastectomy, have been consistently rising. Advances in surgical adjuncts and technology, such as acellular dermal matrices (ADM), have made DTI reconstruction safer and more reliable. However, few studies have characterized early (30-day) postoperative complications following DTI. The aim of this study was to obtain a current understanding of early postoperative outcomes following DTI breast reconstruction. Methods: Using data from the American College of Surgeons-National Surgical Quality Improvement Program, we analyzed complications for female patients who underwent DTI reconstruction from 2017 to 2019, as well as trends in DTI reconstruction from data on mastectomy and DTI reconstruction from 2010 to 2019. We grouped complications into major surgical (including return to the operating room) or medical complications. Statistical analysis was performed using Fischer's exact test for categorical variables, Student's t-test for continuous variables, and logistic regression. Results: DTI breast reconstruction rates have increased since 2010. Among our 2017-2019 cohort of 4204 patients, the early major surgical complication rate was approximately 10% (422 patients) and the major medical complication rate was 0.83% (35 patients). Regression modeling identified body mass index, smoking status, hypertension, bleeding disorders, and intraoperative blood transfusion as having a relationship with surgical complications (P < .001). Conclusions: Despite increased use of ADM and indocyanine green angiography, compared to prior studies, early postoperative complications have remained stable. Further studies are needed to assess long-term complications and patient-reported outcomes in DTI breast reconstruction.

背景:乳房直接植入(DTI)乳房重建术,即在乳房切除术时放置乳房植入物,其比例一直在上升。手术辅助工具和技术的进步,如脱细胞真皮基质(ADM),使DTI重建更安全、更可靠。然而,很少有研究描述DTI术后早期(30天)并发症。本研究的目的是获得DTI乳房重建后早期术后结果的当前理解。方法:利用美国外科医师学会-国家手术质量改进计划的数据,分析2017 - 2019年接受DTI重建的女性患者的并发症,以及2010 - 2019年乳房切除术和DTI重建数据的DTI重建趋势。我们将并发症分为主要手术(包括返回手术室)或内科并发症。统计分析采用分类变量的Fischer精确检验,连续变量的Student t检验和逻辑回归。结果:自2010年以来,DTI乳房重建率有所上升。在2017-2019年4204例患者队列中,早期主要手术并发症发生率约为10%(422例),主要内科并发症发生率为0.83%(35例)。回归模型确定体重指数、吸烟状况、高血压、出血性疾病和术中输血与手术并发症有关系(P < 0.001)。结论:尽管ADM和吲哚菁绿血管造影的使用增加,但与先前的研究相比,早期术后并发症保持稳定。需要进一步的研究来评估DTI乳房重建的长期并发症和患者报告的结果。
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引用次数: 0
The Effect of Nitroglycerin Treatment Initiation Time on Survival in Partial Flap Necrosis: An Experimental Study. 硝酸甘油治疗起始时间对部分皮瓣坏死患者生存率影响的实验研究
IF 0.7 4区 医学 Q4 SURGERY Pub Date : 2024-08-01 Epub Date: 2022-10-19 DOI: 10.1177/22925503221128984
Galip Gencay Üstün, Güven Ozan Kaplan, Ebru Öztürk, Özay Gököz, Figen Özgür

Background: Nitroglycerin is suggested to improve flap survival based on promising results; however, there are no data on the effectiveness of treatment initiation time. This study aimed to compare the effect of various nitroglycerin treatment initiation times on partial flap survival. Materials and Methods: The study included 50 Sprague-Dawley rats. Modified McFarlane flaps were elevated on the dorsum of each rat. Group A received placebo treatment. Groups B, C, D, and E received topical nitroglycerin 2% starting 1 day before surgery, on the day of surgery, postoperative d 2, and postoperative d 4, respectively. After 7 days, the flap survival rates were calculated. Afterward, the severity and extent of inflammation and ischemia, and the severity of edema were evaluated histologically. Results: The flap survival rate was highest in group B, followed by groups C, D, E, and A. The difference between groups B and C was not significant, whereas the difference between group B and groups A, D, and E was. In addition, the difference between groups A, D, and E was not significant. Histological analysis showed that inflammation was less severe in groups B and C than in groups A, D, and E. Ischemia was the most severe in groups A and D and was the least severe in group C. Conclusion: Topical nitroglycerin treatment increases flap survival when initiated before or on the day of surgery, but has no benefit when initiated on postsurgery d 2 or 4. Preoperative initiation of nitroglycerin treatment positively affects flap survival.

背景:硝酸甘油被认为可以提高皮瓣的存活率,这是有希望的结果;然而,目前还没有关于治疗开始时间有效性的数据。本研究旨在比较不同硝酸甘油治疗起始时间对部分皮瓣存活率的影响。材料和方法:本研究包括50只Sprague-Dawley大鼠。在每只大鼠的背侧抬高改良的McFarlane皮瓣。A组接受安慰剂治疗。B组、C组、D组和E组分别在手术前1天、手术当天、术后第2天和术后第4天开始接受2%的局部硝酸甘油治疗。7天后,计算皮瓣的存活率。之后,对炎症和缺血的严重程度和程度以及水肿的严重程度进行组织学评估。结果:B组皮瓣成活率最高,其次是C、D、E和A组。B组和C组之间的差异不显著,而B组与A、D和E组之间的差别为。此外,A、D和E组之间的差异也不显著。组织学分析显示,B组和C组的炎症程度低于A组、D组和E组。A组和D组的缺血最严重,C组的缺血程度最低。术前开始硝酸甘油治疗对皮瓣存活率有积极影响。
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