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2013 Transducers & Eurosensors XXVII: The 17th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS & EUROSENSORS XXVII)最新文献

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Large-capacity-on-chip preconcentrator device for selective ethylene measurement below 400 PPBV 用于400 PPBV以下乙烯选择性测量的大容量片上预浓缩装置
S. Janßen, T. Teßmann, M. Niessen, A. Sklorz, W. Lang
The small gas chromatograph presented in this paper was for the first time able to detect an ethylene concentration of 400 ppbv. Deduced from this measurement a detection limit below 50 ppbv can be reached which is absolutely mandatory for the shelf life prediction of climacteric fruits. To achieve the necessary sensitivity a complete new large-capacity-on-chip preconcentrator device was realized. New stationary phases were tested. The used packed gas chromatography column is now capable to separate vaporized water and ethylene gas from each other which was a yields a breakthrough in the analysis of ethylene concentrations in ambient air.
本文提出的小型气相色谱仪首次能够检测浓度为400 ppbv的乙烯。从这一测量推断,可以达到低于50 ppbv的检测限,这对于更年期水果的保质期预测是绝对强制性的。为了达到所需的灵敏度,实现了一种全新的大容量片上预富集装置。测试了新的固定相。使用的填充气相色谱柱现在能够将汽化水和乙烯气体相互分离,这是环境空气中乙烯浓度分析的一个突破。
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引用次数: 3
Large displacement plastic deformation process for silicon parasol structure 硅伞结构的大位移塑性变形过程
T. Aono, Y. Ebata, S. Matsui, T. Watanabe
A large displacement silicon parasol structure has been realized using a developed two-step silicon plastic deformation process. This process consists of three key processes: first, plastic deformation at high temperature and applying a load from one side; second, two-step plastic deformation for large displacement and third, canopy release after plastic deformation. Accordingly, the silicon parasol structure with a diameter of 30 mm and a curvature radius of 100 mm can be fabricated by the developed plastic deformation process.
采用开发的两步硅塑性变形工艺,实现了大位移硅遮阳伞结构。这一过程包括三个关键过程:第一,高温下的塑性变形和从一侧施加载荷;二是大位移时的两步塑性变形,三是塑性变形后的冠层释放。据此,利用所开发的塑性变形工艺可制备直径为30 mm、曲率半径为100 mm的硅遮阳伞结构。
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引用次数: 2
A micromachined integrated gyroscope and accelerometer based on gas thermal expansion 一种基于气体热膨胀的微机械集成陀螺仪和加速度计
Song Lin Cai, R. Zhu, Henggao Ding, Yong Jun Yang, Yan Su
This paper reports a novel micromachined integrated gyroscope and accelerometer based on gas thermal expansion. Using gas movement induced by alternating heat expansion in a micro chamber instead of a solid proof mass movement, a new type of micro gyroscope with a wide-range rotation detectability incorporating with 1-axis acceleration sensing is accomplished. Experiments demonstrate a good linearity of the rotation output in response to the angular rate from -3000 °/s to +3000 °/s and the acceleration output in response to the acceleration in the range of ±1g, which validate the simultaneous measurements of 1-axis angular rate and 1-axis acceleration in one chip. Meanwhile, the coupling effects among 3-axis rotations and accelerations are investigated experimentally to demonstrate low coupling effect via using thermal expansion flow.
本文报道了一种新型的基于气体热膨胀的微机械集成陀螺仪和加速度计。利用微腔内交变热膨胀引起的气体运动代替非固体质量运动,实现了一种具有大范围旋转检测能力并结合一轴加速度传感的新型微陀螺仪。实验表明,在-3000°/s ~ +3000°/s范围内,响应角速度的旋转输出和响应加速度在±1g范围内的加速度输出具有良好的线性关系,验证了在一个芯片上同时测量一轴角速度和一轴加速度的可行性。同时,通过实验研究了三轴旋转和加速度之间的耦合效应,证明了热膨胀流的低耦合效应。
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引用次数: 18
A microcalorimeter with in-situ synthesized nanotube adsorber for trace energetic substance detection 原位合成纳米管吸附微热量计用于痕量能物质检测
W. Ruan, Y. Li, Z. Tan, Z. Y. Wang
We have developed a microcalorimeter with carbon nanotube adsorber (CNA) integrated on a suspended microcalorimeter for detection of trace energetic substance. The energetic substance vapors are adsorbed onto the CNA surfaces and are heated to micro deflagration using a heater integrated on the microcalorimeter. The released heat from micro deflagration raises the temperature of the microcalorimeter, which is detected by an integrated thermistor as an indicator of energetic substances. The huge surface areas of the CNA facilitate the adsorption to the energetic substances, and are helpful to achieving fast adsorption. The microcalorimeter is able to detect 2,4,6-trinitrotoluene (TNT) with a limit of detection of 2.6 pg and reduce the adsorption time as much as 60% compared without CNA.
我们研制了一种将碳纳米管吸附剂集成在悬浮式微量热计上的微量热计,用于痕量能物质的检测。含能物质蒸气被吸附到CNA表面上,并使用集成在微热量计上的加热器加热至微爆燃。微爆燃释放的热量提高了微热量计的温度,微热量计的温度由集成热敏电阻检测,作为高能物质的指示。CNA的巨大表面积有利于吸附含能物质,有助于实现快速吸附。微热量计能够检测2,4,6-三硝基甲苯(TNT),检测限为2.6 pg,与不使用CNA相比,吸附时间缩短了60%。
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引用次数: 0
Self focusing acoustic transducer (SFAT) with 10-mm focal length for cancer-specific localized cytolysis of 3D cell spheroids in 3D Matrigel 10毫米焦距的自聚焦声换能器(SFAT)用于三维矩阵中肿瘤特异性局部细胞溶解
Lingtao Wang, Chun-Peng Liao, M. Gross, E. S. Kim
This paper reports three-dimensional (3D) localized cytolysis of cell spheroids by Self Focusing Acoustic Transducers (SFAT) with 10 mm focal length. In previous studies, it has been demonstrated that an SFAT with 800 μm focal length caused localized cytolysis on monolayer cells. Since practical ultrasonic cancer therapeutics are usually performed in a 3D biological environment, an SFAT having a long penetration depth and focusing acoustic energy at 10 mm within an area of 160 μm in diameter has been designed and fabricated. Also, the acoustic intensity thresholds (AITs) of spheroids for cancer-specific cytolysis of malignant cells (breast cancer MCF-7 and prostate cancer 22RV1) are investigated. According to experiments with the spheroids in 3D Matrigel environment, the crosslinks between Matrigel and spheroids greatly increase AITs of 22RV1 and MCF-7 cell spheroids from 0.11 W/cm2 to 11.10 ~ 15.14 W/cm2. In addition, in both “unsolidified” (without crosslink) and solidified (with crosslink) Matrigel environments, spheroids of non-malignant cell line MCF-10A are not lysed even with two to three times higher acoustic intensities than the AITs of MCF-7. Therefore, the general trend associating a lower AIT with a more malignant still stands for MCF-7 and MCF-10A 3D spheroids in 3D Matrigel environment.
本文报道了利用焦距为10mm的自聚焦声换能器(SFAT)对细胞球体进行三维(3D)局部细胞溶解。在先前的研究中,已经证明了800 μm焦距的SFAT可以局部溶解单层细胞。由于实际的超声癌症治疗通常在三维生物环境中进行,因此设计并制造了一种具有长穿透深度并在直径160 μm的区域内聚焦10 mm声能的SFAT。此外,还研究了球形细胞对恶性细胞(乳腺癌MCF-7和前列腺癌22RV1)的特异性细胞溶解的声强阈值(AITs)。在三维Matrigel环境下对球体的实验表明,Matrigel与球体的交联使22RV1和MCF-7细胞球体的AITs从0.11 W/cm2提高到11.10 ~ 15.14 W/cm2。此外,在“未固化”(无交联)和固化(有交联)的基质环境中,即使声强度比MCF-7的ait高2 - 3倍,非恶性细胞系MCF-10A的球体也不会被裂解。因此,在3D Matrigel环境下,MCF-7和MCF-10A三维球体的AIT越低,恶性程度越高的总体趋势仍然存在。
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引用次数: 2
A biological/electrochemical reservoirs integrated microsensor for the determination of biochemical oxygen demand 一种用于生化需氧量测定的生物/电化学储层集成微传感器
J. Wang, C. Bian, J. Tong, J. Sun, Y. Li, H. Zhang, S. Xia
In this paper, a novel Biochemical Oxygen Demand (BOD) microsensor consisted of a biological reservoir and an electrochemical reservoir was fabricated by Micro Electro-Mechanical System (MEMS) technology. The consumption of Dissolved Oxygen (DO) is occurred in biological reservoir by respiration of the microbial, and the change of DO was detected in the electrochemical reservoir by the integrated microelectrode array (MEA). Because of the hemispherical diffusion mode of the MEA, the increase in current densities, the enhancement in mass transport and the increase in signal-to-noise ratios were displayed. The fabricated microsensor showed linear response to DO ranging from 0.5 mg/L to 7.2 mg/L and linear response to BOD ranging from 0 to 20 mg/L. The satisfied results showed that the miniaturized BOD microsensor can be used to detect BOD in the solution, and this method can be applied in other microsystem fabrication.
本文采用微机电系统(MEMS)技术,制作了一种新型生化需氧量(BOD)微传感器,该传感器由生物储层和电化学储层组成。生物储层中溶解氧(DO)通过微生物的呼吸作用消耗,利用集成微电极阵列(MEA)检测电化学储层中溶解氧的变化。由于MEA的半球形扩散模式,电流密度增加,质量输运增强,信噪比增加。该微传感器对DO的响应范围为0.5 ~ 7.2 mg/L,对BOD的响应范围为0 ~ 20 mg/L。结果表明,该微型BOD微传感器可用于检测溶液中的BOD,该方法可应用于其他微系统制造。
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引用次数: 1
Development of pH sensor with enhanced sensitivity using volume of bubbles generated by electrolysis 利用电解产生的气泡体积提高灵敏度的pH传感器的研制
J. Sim, D. Kwon, J. Kim
We have demonstrated a novel and simple pH sensor using electrolysis process. The pH sensor is composed of actuating and sensing electrodes sets, micro-channel and micro-reservoir embedded PDMS part. The electrodes on silicon substrate are formed by a single-step lift-off, and the channel and reservoir are molded on PDMS. The volume of hydrogen bubbles generated by electrolysis is dependent on the pH value, and the bubbles push the pH buffer solution in the reservoir into the micro-channel. The pushed distance results in the current changes between the sensing electrodes. The experimental results show that the developed pH sensor gives enhanced sensing response at strong acid, and the sensing resolution can be enhanced as the electrolysis time increases.
我们展示了一种新颖而简单的电解pH传感器。pH传感器由驱动和传感电极组、微通道和微储槽嵌入式PDMS部分组成。电极在硅衬底上通过一步升降形成,通道和储层在PDMS上成型。电解产生的氢气气泡的体积取决于pH值,气泡将储层中pH值的缓冲溶液推入微通道。推挤的距离导致感应电极之间的电流变化。实验结果表明,所研制的pH传感器在强酸环境下具有较强的传感响应,且随着电解时间的延长,传感分辨率有所提高。
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引用次数: 0
Applications of nanoNewton dielectrophoretic forces using atomic layer deposited oxides for microfluidic sample preparation and proteomics 纳米牛顿介电泳力在原子层沉积氧化物微流体样品制备和蛋白质组学中的应用
S. Emaminejae, M. Javanmare, C. Gupta, R. Dutton, R. W. Davis, R. Howe
By increasing the strength of the negative dielectrophoresis (DEP) force, we demonstrate a significantly improved electrokinetic actuation and filtering microsystem. A pinhole-free, nanometer-scale, thin film oxide was deposited using atomic layer deposition, as a protective layer to protect the electrodes from corrosion, when applying high AC voltages (>20 Vpp) at the electrodes. The electrodes were capacitively coupled to the electrolyte buffer by the application of a high frequency AC voltage signal, thus avoiding electric field degradation and the consequent reduction in dielectrophoresis force due to the presence of the insulating oxide layer. In this work, we demonstrated the use of this DEP-enhanced device for two microfluidic applications. First, we demonstrate an on-chip platform for the depletion of cells and highly abundant serum proteins in blood, which is a prerequisite to assay low-abundance protein biomarkers. For the second application, we show 100% detachment of anti-IgG and IgG bound beads (which is on the same order of magnitude in strength as typical antibody-antigen interactions) from the surface, upon the application of the enhanced negative DEP force. This capability offers the possibility of performing a bead-based multiplexed assay against multiple antigen targets where in a single microfluidic channel various regions are immobilized with a different antibody, each targeting a different antigen.
通过增加负电介质电泳(DEP)力的强度,我们展示了一个显着改进的电动驱动和过滤微系统。当施加高交流电压(>20 Vpp)时,采用原子层沉积法沉积无针孔的纳米级氧化薄膜,作为保护电极免受腐蚀的保护层。通过应用高频交流电压信号,电极与电解质缓冲液电容耦合,从而避免了由于绝缘氧化层的存在而导致的电场退化和随后的介电电泳力降低。在这项工作中,我们展示了在两个微流控应用中使用这种深度增强型装置。首先,我们展示了一个芯片平台,用于血液中细胞和高丰度血清蛋白的消耗,这是测定低丰度蛋白质生物标志物的先决条件。对于第二次应用,我们展示了在应用增强的负DEP力后,抗IgG和IgG结合珠100%脱离表面(其强度与典型抗体-抗原相互作用的强度相同)。这种能力提供了针对多种抗原靶标进行基于头的多路检测的可能性,其中在单个微流控通道中,不同的区域用不同的抗体固定,每个抗体靶向不同的抗原。
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引用次数: 2
Piezoresistive pressure sensor with dual-unit configuration for on-chip self-compensation and suppression of temperature drift 压阻式压力传感器具有双单元配置,用于片上自补偿和抑制温度漂移
J. C. Wang, X. Xia, H. Zou, F. Song, Xinxin Li
With our developed MIS (Microholes Inter-etch & Sealing) micromachining process that is implemented only from the front-side of single-side polished (111) silicon wafers, a novel piezoresistive pressure sensing unit and another identically structured pressure-insensitive dummy unit are on-chip integrated compactly to eliminate unbalance factors induced temperature-drift by mutual compensation between the two units. In addition, the two units are both suspended from silicon substrate to suppress the packaging-stress. The high-performance pressure sensors are low-cost fabricated in a single (111)-wafer by repeatedly using the single-sided MIS process. The tested ultra-low TCO (temperature coefficient of offset) of 0.002%/°C·FS (-40°C to +125°C) well verifies the highly stable performance of the developed sensor structure.
我们开发的MIS (Microholes interetch & sealed)微加工工艺仅从单面抛光(111)硅片的正面实施,一种新型的压阻式压力传感单元和另一种结构相同的压力不敏感虚拟单元被紧凑地集成在片上,通过两个单元之间的相互补偿来消除不平衡因素引起的温度漂移。此外,这两个单元都悬浮在硅衬底上以抑制封装应力。通过重复使用单面MIS工艺,在单(111)晶圆中低成本制造高性能压力传感器。经测试的超低TCO(偏移温度系数)为0.002%/°C·FS(-40°C至+125°C),很好地验证了所开发传感器结构的高稳定性。
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引用次数: 7
Transportation of mono-dispersed micro-plasma bubble in microfluidic chip under atmospheric pressure 常压下微流控芯片内单分散微等离子体气泡的输运
Y. Yamanishi, S. Sameshima, H. Kuriki, S. Sakuma, F. Arai
We have successfully produced mono-dispersed micro-scale plasma bubble in microfluidic chip under atmospheric pressure, and which can be transported to the downstream of the chip. The plasma produced has characteristics of low temperature and which was generated by dielectric barrier discharge for biomedical applications. The discretized plasma phase in microfluidic chip provides high accuracy irradiation to the affected area with limited collateral damage area. This technique is closely tied to the therapeutic uses with high accuracy.
我们成功地在常压条件下在微流控芯片中产生了单分散的微尺度等离子体气泡,并可将其输送到芯片下游。利用介质阻挡放电产生的等离子体具有低温特性,可用于生物医学。微流控芯片采用离散等离子体相对受损伤区域进行高精度辐照,附带损伤面积小。该技术与高精度的治疗用途密切相关。
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引用次数: 5
期刊
2013 Transducers & Eurosensors XXVII: The 17th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS & EUROSENSORS XXVII)
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