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Thromboelastography (TEG) Point-of-Care Diagnostic for Hemostasis Management 血栓弹性成像(TEG)即时诊断止血管理
Pub Date : 2018-03-01 DOI: 10.1097/POC.0000000000000156
J. Hartmann, D. Mason, Hardean E. Achneck
Abstract Thromboelastography is a method of assessing the coagulation status of patients. Unlike standard laboratory–based coagulation tests (eg, prothrombin time and activated partial thromboplastin time), it provides a holistic, functional perspective on the entire coagulation process; and point-of-care application provides results more quickly. Across a wide range of clinical settings, thromboelastography can be used to assess the risk of bleeding or thromboembolic events and to guide management of hemostatic equilibrium. Until recently, the principal system for performing thromboelastography was the TEG 5000 analyzer. The TEG 6s system, which consists of the TEG 6s analyzer and disposable cartridges, measures the same properties as the TEG 5000 and was recently developed to increase the ease and precision with which thromboelastography is performed. By measuring the velocity of clot formation, the strength of the clot, contributions of fibrinogen and platelets to clot strength, and the speed/extent of fibrinolysis, a comprehensive insight into the patient's coagulation status is gained. Treatment can then be individualized to ensure effective coagulation management while avoiding exposure to unnecessary treatment. Subsequently, the effect of treatment can be assessed to determine whether further intervention may be required. We review the clinical use of thromboelastography in trauma, cardiovascular surgery, liver transplantation, obstetrics, congenital bleeding disorders, and other settings. Increased uptake of thromboelastography has the potential to improve standards of patient care and to lead to health economic benefits.
摘要血栓弹性成像是一种评估患者凝血状态的方法。不像标准的实验室为基础的凝血试验(例如,凝血酶原时间和活化部分凝血活素时间),它提供了一个整体的,功能的角度对整个凝血过程;即时护理应用可以更快地提供结果。在广泛的临床环境中,血栓弹性成像可用于评估出血或血栓栓塞事件的风险,并指导止血平衡的管理。直到最近,执行血栓弹性成像的主要系统是TEG 5000分析仪。TEG 6s系统由TEG 6s分析仪和一次性药筒组成,测量与TEG 5000相同的性能,最近开发用于提高血栓弹性成像的易用性和精度。通过测量凝块形成的速度、凝块的强度、纤维蛋白原和血小板对凝块强度的贡献以及纤维蛋白溶解的速度/程度,可以全面了解患者的凝血状态。然后可以个体化治疗,以确保有效的凝血管理,同时避免不必要的治疗。随后,可以评估治疗效果,以确定是否需要进一步干预。我们回顾了血栓弹性成像在创伤、心血管手术、肝移植、产科、先天性出血性疾病和其他情况下的临床应用。增加血栓弹性成像有可能提高患者护理标准,并带来健康经济效益。
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引用次数: 21
Validation of the Nova Point-of-Care Testing StatStrip &bgr;-Ketone Test in a Laboratory and Clinical Setting Nova即时护理测试StatStrip -酮测试在实验室和临床环境中的验证
Pub Date : 2018-03-01 DOI: 10.1097/POC.0000000000000155
S. Vandamme, Kore Van Mechelen, Hugo Cluckers, V. Van Hoof
E ach year in Belgium, 2000 patients are newly diagnosed with type 1 diabetes mellitus (DM) and 23,500 patients with type 2 DM. Diabetic ketoacidosis (DKA) is a severe acute complication of DM, with a prevalence around 30% in type 1 DM and 6% in type 2 DM. Guidelines advocate whole-blood measurement of beta-hydroxybutyrate (βHB) for the management of DKA, making point-of-care testing (POCT) devices for glucose and ketones an important and lifesaving tool. At the request of our emergency department (ED), the POCT hospital meter StatStrip (Nova Biomedical, Waltham, Mass) was installed on trial.
在比利时,每年有2000名新诊断为1型糖尿病(DM)的患者和23,500名2型糖尿病患者。糖尿病酮症酸中毒(DKA)是糖尿病的严重急性并发症,在1型糖尿病中患病率约为30%,在2型糖尿病中患病率约为6%。指南提倡全血测量β -羟基丁酸(βHB)来管理DKA,使葡萄糖和酮类的护理点检测(POCT)设备成为重要的救生工具。应急诊科(ED)的要求,POCT医院计量器StatStrip (Nova Biomedical, Waltham, Mass)被安装在试验中。
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引用次数: 0
The Effectiveness of Fetal Lactate Measurement in the Assessment of Fetal Acidemia Using StatStrip Lactate Meter 用StatStrip乳酸计测定胎儿乳酸在评估胎儿酸血症中的有效性
Pub Date : 2018-03-01 DOI: 10.1097/POC.0000000000000154
V. Olagundoye, S. Ijaz
F etal lactate measurement in labor has been shown to be as effective as pH in the assessment and identification of fetal hypoxia. Fetal lactate is widely used in northern Europe, New Zealand, and United States to assess fetal acidemia. It has been endorsed by theNational Institute for Health and Care Excellence since December 2014. StatStrip Lactate is a rapid handheld point of care (POC) meter for the measurement of whole blood lactate level providing results within 13 seconds of testing thus enabling early identification of hyperlactatemia and babies at risk of hypoxia. Our study was carried out at City Hospital, Birmingham UK, a busy district general hospital.
在分娩中测量胎儿乳酸已被证明是有效的评估和鉴定胎儿缺氧的pH值。在北欧、新西兰和美国,胎儿乳酸被广泛用于评估胎儿酸血症。自2014年12月以来,它已得到国家健康与护理卓越研究所的认可。StatStrip Lactate是一种快速手持式护理点(POC)计,用于测量全血乳酸水平,在13秒内提供测试结果,从而能够早期识别高乳酸血症和有缺氧风险的婴儿。我们的研究是在英国伯明翰市城市医院进行的,这是一家繁忙的地区综合医院。
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引用次数: 0
Point-of-Care Abstracts From the 2017 American Association for Clinical Chemistry Meeting (Reprinted with permission) 2017年美国临床化学协会会议护理点摘要(经许可转载)
Pub Date : 2018-01-01 DOI: 10.1097/POC.0000000000000158
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引用次数: 0
A First Impression of Point-of-Care Testing in Spain: Spanish Society of Clinical Biochemistry Survey Results 在西班牙的护理点测试的第一印象:西班牙社会临床生物化学调查结果
Pub Date : 2017-12-01 DOI: 10.1097/POC.0000000000000148
F. J. Lirón-Hernández, Paloma Oliver-Sáez, Catalina Sánchez-Mora, O. Rodríguez-Fraga
Abstract The use of point-of-care testing (POCT) technology has increased every year worldwide. In Spain, there are no data about how these tests are used and where they are performed, and there is no clear vision of what is the role of laboratory regarding these tests. The POCT Committee, in the Spanish Society of Clinical Biochemistry, carried out a survey in order to find out what the situation is with POCT in the country from a laboratory POCT manager's point of view. The survey had 19 questions: 3 for segmentation, 1 for opinion, 13 to obtain specific information about POCT in their hospitals, and 2 about personal information. To enable a response, a survey link was shared in the Spanish Society of Clinical Biochemistry Web page. Responses were obtained via Google Docs Web page, where coworkers were requested to fill in the survey. The survey was answered by 140 laboratories, but only 126 of the responses were considered valid. The survey results generally showed that the situation in Spain is similar to that in other countries as documented by similar national surveys on POCT. The survey also demonstrated room for improvement in POCT practices and a need for governmental regulation to improve POCT processes.
在世界范围内,点护理检测(POCT)技术的使用每年都在增加。在西班牙,没有关于如何使用和在何处进行这些检测的数据,也没有关于实验室在这些检测方面的作用的明确设想。西班牙临床生物化学学会的POCT委员会进行了一项调查,以便从实验室POCT管理人员的角度了解该国POCT的情况。调查共有19个问题:3个问题用于细分,1个问题用于意见,13个问题用于获取其所在医院POCT的具体信息,2个问题用于个人信息。为了得到回应,西班牙临床生物化学学会的网页上分享了一个调查链接。我们通过谷歌Docs网页获得了反馈,并要求同事填写调查问卷。140个实验室回答了这项调查,但只有126个回答被认为是有效的。调查结果普遍表明,西班牙的情况与其他国家类似的POCT全国调查所记录的情况相似。调查还显示了POCT实践的改进空间,以及政府监管改进POCT流程的必要性。
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引用次数: 0
Accuracy of CoaguChek XS in Patients With Antiphospholipid Syndrome CoaguChek XS在抗磷脂综合征患者中的准确性
Pub Date : 2017-12-01 DOI: 10.1097/POC.0000000000000149
James R. Taylor, C. Richter, Chris Lindamood, Xinyu Liu, M. Zumberg, Brad Fletcher
Abstract The CoaguChek XS meter is an international normalized ratio (INR) point-of-care (POC) monitor that has been shown to provide clinically acceptable accuracy. Because of a potential interaction between antiphospholipid antibodies and the reagent used in the prothrombin time INR assay, there is uncertainty as to the reliability of using POC INR monitors in patients with antiphospholipid syndrome (APLS). The study population consisted of 41 patients on warfarin therapy for either APLS (treatment group) or any other indication (control group). All patients had their INR analyzed by the CoaguChek XS meter and a central laboratory. Overall, the mean INR difference between the CoaguChek XS and laboratory in the APLS patients was 0.6772 (P < 0.0001). In APLS patients, when the laboratory INR was less than 2.0, 2.0 to 3.0, 3.1 to 4.0, or greater than 4.0, the CoaguChek XS differed by averages of 0.0636 (P = 0.4111), 0.6903 (P < 0.0001), 1.1417 (P < 0.0001), and 0.9333 (P = 0.0848), respectively. In the control group the overall mean difference was 0.5456 (P < 0.0001). For laboratory INR values of less than 2.0, 2.0 to 3.0, 3.1 to 4.0, and greater than 4.0, the mean differences from the CoaguChek XS were 0.3000 (P = 0.0003), 0.4444 (P < 0.0001), 1.0444 (P = 0.0002), and 1.3500 (P = 0.0236). Our data do support the manufacturer recommendation of comparing laboratory and CoaguChek XS meter INRs in APLS patients because in a subset of patients the 2 methods produced acceptable results, and POC monitoring might be used.
CoaguChek XS仪表是一种国际标准化比率(INR)护理点(POC)监测仪,已被证明提供临床可接受的准确性。由于抗磷脂抗体与用于凝血酶原时间INR测定的试剂之间存在潜在的相互作用,因此在抗磷脂综合征(apl)患者中使用POC INR监测器的可靠性存在不确定性。研究人群包括41例接受华法林治疗的apl患者(治疗组)或任何其他适应症(对照组)。所有患者的INR均由CoaguChek XS仪器和中心实验室进行分析。总体而言,CoaguChek XS与实验室在apl患者中的平均INR差异为0.6772 (P < 0.0001)。在apl患者中,当实验室INR小于2.0、2.0 ~ 3.0、3.1 ~ 4.0、大于4.0时,CoaguChek XS的平均差异分别为0.0636 (P = 0.4111)、0.6903 (P < 0.0001)、1.1417 (P < 0.0001)、0.9333 (P = 0.0848)。对照组总平均差异为0.5456 (P < 0.0001)。实验室INR值小于2.0、2.0 ~ 3.0、3.1 ~ 4.0和大于4.0时,与CoaguChek XS的平均差异分别为0.3000 (P = 0.0003)、0.4444 (P < 0.0001)、1.0444 (P = 0.0002)和1.3500 (P = 0.0236)。我们的数据确实支持制造商在apl患者中比较实验室和CoaguChek XS仪表INRs的建议,因为在一部分患者中,这两种方法产生了可接受的结果,并且可以使用POC监测。
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引用次数: 5
A Multicenter Evaluation of the Quality Management Practices for Point-of-Care Testing in Nigeria 多中心评价的质量管理实践的护理点测试在尼日利亚
Pub Date : 2017-12-01 DOI: 10.1097/POC.0000000000000152
I. Nnakenyi, C. Onyenekwu, L. Imoh, N. Ntuen, I. Mohammed, C. Nlemadim
Introduction The need for timely patient management has led to the proliferation of point-of-care testing (POCT) within health care facilities. However, POCT is often implemented without supervision by laboratory personnel, which raises concern about the quality of its results. The aim of this study was to determine the quality management practices for POCT in several Nigerian tertiary hospitals. Materials and Method This was a descriptive study of 61 POCT sites at 5 tertiary hospitals across Nigeria. Research laboratories and self-monitoring POCT were excluded. Data were collected using interviewer-administered questionnaires, as well as visual inspection of records and facilities. Results were presented as counts and percentages. Results The predominant POCT was the glucometer (65%). Cost of testing was majorly 0 to 500 naira (<2 US dollars; 78%). Point-of-care testing sites were majorly operated by physicians 40%, and only 26% of the sites had documentation of training on the POCT before use. Method validation was not performed in 81% of the sites. Internal quality control and external quality assessment were performed at 26% and 10% of the sites, respectively. There was no traceability of results on the device to the patients tested at 78% of the sites. Troubleshooting a faulty device was performed by nonlaboratorians at 77% of the sites. Most sites did not involve the laboratory in device procurement (74%), validation (77%), maintenance (78%), troubleshooting (64%), or monitoring the accuracy of the results (74%). None of the hospitals had a POCT committee. Discussion The practice of quality management for POCT in tertiary hospitals was poor because of inadequately trained operators and noninvolvement of the laboratory. Laboratory staff should provide guidance and a framework for POCT implementation to ensure quality results and patient safety.
对患者及时管理的需求导致了卫生保健机构内护理点检测(POCT)的普及。然而,POCT通常在没有实验室人员监督的情况下实施,这引起了对其结果质量的担忧。本研究的目的是确定尼日利亚几家三级医院POCT的质量管理实践。材料和方法本研究对尼日利亚5家三级医院的61个POCT站点进行了描述性研究。排除研究实验室和自我监测POCT。数据是通过访谈者填写的问卷以及对记录和设施的目视检查来收集的。结果以计数和百分比表示。结果主要POCT为血糖仪(65%)。检测费用主要为0 - 500奈拉(<2美元;78%)。40%的测试点主要由医生操作,只有26%的测试点在使用POCT前有培训文件。81%的地点未进行方法验证。内部质量控制和外部质量评估分别在26%和10%的站点进行。在78%的检测地点,设备上的检测结果无法追踪到患者。故障设备的故障排除是由非实验室人员在77%的站点进行的。大多数场所在设备采购(74%)、验证(77%)、维护(78%)、故障排除(64%)或监测结果准确性(74%)中没有让实验室参与。没有一家医院有POCT委员会。三级医院POCT质量管理实践较差,原因是操作人员培训不足,实验室不参与。实验室工作人员应为POCT的实施提供指导和框架,以确保质量结果和患者安全。
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引用次数: 3
A Novel Approach to Assess Performance of Glucometer: Error Grid Analysis 一种评估血糖仪性能的新方法:误差网格分析
Pub Date : 2017-12-01 DOI: 10.1097/POC.0000000000000150
Vandana Kumavat, M. Rojekar, Jayesh Panot, Arati Adhe-Rojekar
Abstract Glucose meters are excellent tools for self-monitoring of blood glucose especially in the circumstances where continuous monitoring is mandatory and at decision-making levels. Tight glycemic control protocols are important for preventing ill effects of fluctuating glucose levels. As technology advances, glucometers are getting better in terms of quality of results. The purpose here is to study the quality of glucose meter results in terms of clinical outcomes. The study was conducted in a tertiary care referral hospital. A total of 125 patients were recruited from pediatric wards. Bland-Altman plot, Parke error grid, and surveillance error grid analysis were used for comparing the results of the glucose meters with a standard laboratory method. It was found that there was a significant difference between the results of the 2 methods. Although usually minimal, the glucose meter results deviated from the results of the standard laboratory method. This will affect overall patient care especially in emergency conditions. Sometimes, the risk may be so high that the patient may be mislabeled as hypoglycemic when they actually are hyperglycemic and vice versa. This study is the first of its kind because no similar studies have been reported in the pediatric population. For effective use of glucose meters, the devices should give as accurate results as possible. Results should not only be accurate but also precise, without which critical errors may be possible. We recommend that for any glucose meter there should be regular calibration so that agreement with the reference laboratory method is maintained and effective medical decisions are possible.
血糖仪是自我监测血糖的优秀工具,特别是在需要连续监测和决策的情况下。严格的血糖控制方案对于预防血糖水平波动的不良影响非常重要。随着技术的进步,血糖仪在结果质量方面越来越好。这里的目的是研究血糖仪结果的质量在临床结果方面。这项研究是在一家三级保健转诊医院进行的。从儿科病房共招募125名患者。使用Bland-Altman图、Parke误差网格和监视误差网格分析将血糖仪的结果与标准实验室方法进行比较。发现两种方法的结果有显著性差异。虽然通常最小,但血糖仪的结果偏离了标准实验室方法的结果。这将影响病人的整体护理,特别是在紧急情况下。有时,风险可能非常高,以至于患者可能被错误地标记为低血糖,而实际上他们是高血糖,反之亦然。这项研究是第一次,因为在儿科人群中没有类似的研究报道。为了有效地使用血糖仪,设备应提供尽可能准确的结果。结果不仅要准确,而且要精确,否则可能会出现严重的错误。我们建议对任何血糖仪进行定期校准,以便与参考实验室方法保持一致,并可能做出有效的医疗决策。
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引用次数: 0
Direct-to-Consumer Genetic Testing in the Personalized Medicine Era 个性化医疗时代的直接面向消费者的基因检测
Pub Date : 2017-09-01 DOI: 10.1097/POC.0000000000000146
L. Baudhuin
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引用次数: 0
Direct-to-Consumer Testing: A New Paradigm for Point-of-Care Testing 直接面向消费者的测试:护理点测试的新范例
Pub Date : 2017-09-01 DOI: 10.1097/POC.0000000000000137
N. Tolan
Abstract 2016 CPOCT International Symposium Review. This is an invited submission for the March issue covering the 2016 CPOCT International Symposium. Session 2: Direct to Consumer Testing—the New Face of Point-of-Care?
2016年CPOCT国际研讨会综述。这是2016年CPOCT国际研讨会3月号的特邀投稿。第二场:直接面向消费者的测试——即时医疗服务的新面貌?
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引用次数: 3
期刊
Point of Care: The Journal of Near-Patient Testing & Technology
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