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Efficacy of Oxytocin in Reducing Blood Loss During Abdominal Myomectomy 催产素在腹部子宫肌瘤切除术中减少出血量的疗效
Pub Date : 2021-10-27 DOI: 10.47489/pszmc8573646569
Saira Niaz
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引用次数: 0
Reopening of Universities for On-Campus Teaching In COVID-19 Pandemic: Status of Generalized Anxiety in Medical Students 新冠肺炎疫情下大学复课:医学生广泛性焦虑状况
Pub Date : 2021-08-11 DOI: 10.17632/DJD7XVW6D5.1
Sarosh Saleem, Saadia Shahzad
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引用次数: 0
Comparative Effects of Cane Sugar, Honey & Jaggery on Plasma Glucose Level & Body Weight of Alloxan Induced Diabetic Rats 蔗糖、蜂蜜和粗糖对四氧嘧啶诱导的糖尿病大鼠血糖和体重的影响
Pub Date : 2021-06-26 DOI: 10.47489/pszmc-807-35-3-44-49
Ambreen Anjum
Introduction: Diabetes mellitus is characterized by hyperglycemia with impaired metabolism of carbohydrates, fats, and proteins resulting from insufficiency of secretion or action of insulin. The interplay of genes and environmental factors is believed to stress glucose homeostasis. Simple dietary and lifestyle modifications have a role in prevention and slow progression of the disease. The choice and role of sweeteners (sugars) such as ordinary cane sugar, honey, and jaggery have always been a difficult decision for patients with Type 2 diabetes.Aims & Objectives: Evaluation and comparison of the effects of cane sugar, honey, and jaggery on plasma glucose in the sera and body weights of alloxan-induced male Wistar rats with diabetes.Place and duration of study: The study was conducted at the animal house of Services Institute of Medical Sciences Lahore for a duration of 20 months approximately.Material & Methods: In this experimental study 120 male Wistar (albino) rats were randomly allocated into 4 groups of 30 each. After acclimatization, freshly prepared 2% alloxan monohydrate was administered to all the rats via intraperitoneal injection in a single dose of 120mg/kg body weight. Blood sample via tail tipping method was analyzed for fasting serum glucose at 4th post-diabetes induction day. Rodents having ? 200mg/dl serum glucose were regarded as type 2 diabetes models for further study. All animals had access to usual pelleted diet ad libitum. Diabetic controls in group I were fed with equivalent amount of distilled water. Group II, III and IV rats were fed freshly prepared sweetener containing cane sugar, honey and jaggery solutions respectively in a dose of 1g/kg body weight dissolved in 2ml distilled water on pre-scheduled time of the day for 28 days via oral syringe-dosing. Final serum glucose was estimated at 29thday of study by terminal blood sampling and final body weights were recorded. Data analysis was performed using SPSS version 20.Results: Group III (honey fed) rats had least hyperglycemia of 34.53±77.31mg/dL, followed by group II (cane sugar fed) rats (79.31±73.03 mg/dL) then group I diabetic control rats (88.11±92.56mg/dL) and maximal rise in jaggery fed rats with value of 134.50 mg/dL. Significant reduction (p=0.049) in body weight (-40.50g) was noted in group II rats whereas maximum weight gain occurred in group I (127.57 ±72.475), than those of group IV rats (69.13 ± 92.88) followed by II rats (38.42±89.43).Conclusion: The result demonstrates that honey in type 2 diabetes mellitus possess antidiabetic properties via minimum hyperglycemic and weight gaining effects than processed cane sugar. As it was presumed, minimally processed jaggery has not shown significant beneficial effects on serum glucose and body weight. Owing to the advantageous effects on metabolic profile, honey may be regarded as a relatively safer sweetener in diabetics.
导语:糖尿病以高血糖为特征,并伴有碳水化合物、脂肪和蛋白质代谢受损,这是由于胰岛素分泌或作用不足引起的。基因和环境因素的相互作用被认为是葡萄糖稳态的压力。简单的饮食和生活方式的改变对预防和减缓疾病的进展有作用。甜味剂(糖)的选择和作用,如普通的蔗糖、蜂蜜和粗糖,一直是2型糖尿病患者的一个困难的决定。目的:评价和比较蔗糖、蜂蜜和粗糖对四氧嘧啶诱导的雄性糖尿病Wistar大鼠血清血糖和体重的影响。研究地点和时间:本研究在拉合尔医学科学服务研究所动物馆进行,持续时间约为20个月。材料与方法:将120只雄性Wistar(白化)大鼠随机分为4组,每组30只。适应后,将新鲜配制的2%一水四氧嘧啶按120mg/kg体重单次腹腔注射给大鼠。采用摇尾法测定糖尿病诱导后第4天的空腹血糖。啮齿动物有?以200mg/dl血清葡萄糖为2型糖尿病模型进行进一步研究。所有动物都可以随意使用常规颗粒饲料。1组糖尿病对照组饲喂等量蒸馏水。II组、III组和IV组大鼠分别以1g/kg体重的蔗糖、蜂蜜和糖霜溶液新鲜配制的甜味剂溶于2ml蒸馏水中,每日预先设定时间口服注射给药28天。在研究的第29天,通过最终采血来估计最终的血糖,并记录最终的体重。数据分析采用SPSS version 20。结果:第三组(蜂蜜喂养)大鼠高血糖最低(34.53±77.31mg/dL),其次是第二组(蔗糖喂养)大鼠(79.31±73.03 mg/dL),然后是第一组糖尿病对照大鼠(88.11±92.56mg/dL),糖精喂养大鼠高血糖最高(134.50 mg/dL)。II组大鼠体重显著减少(-40.50g) (p=0.049),而I组大鼠体重增加最多(127.57±72.475),IV组大鼠体重增加最多(69.13±92.88),II组大鼠体重增加最多(38.42±89.43)。结论:蜂蜜对2型糖尿病患者的降糖作用明显优于精制蔗糖。据推测,最低限度加工的粗糖并没有显示出对血糖和体重的显著有益影响。由于对代谢的有利影响,蜂蜜可能被认为是糖尿病患者相对安全的甜味剂。
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引用次数: 0
Morphological Spectrum of Ovarian Teratomas: A 6 Years Experience at a Specialized Diagnostic Institute 卵巢畸胎瘤的形态谱:一家专业诊断机构6年的经验
Pub Date : 2021-06-26 DOI: 10.47489/pszmc-805-35-3-31-36
F. Khalid, S. Afzal, G. Zafar, A. Chughtai, S. Zaman, A. Chughtai
Introduction: Ovarian teratomas include mature cystic teratoma (MCT), immature teratoma (IT) and monodermal teratoma (MoT). Malignant transformation (MT) can occur in MCT and MoT, which remains a diagnostic challenge.Aims & Objectives: To discuss the morphological spectrum of ovarian teratomas reported during the last six years at our specialized diagnostic institute and determine the frequency of MT in MCT and MoT.Place and duration of study: The study was carried out at Chughtai Institute of Pathology from January 2015 to December 2020.Material & Methods: A retrospective study was performed by retrieving 1018 cases of ovarian teratomas reported in last 6 years. SPSS version 20 was used for data analysis.Results: MCT was most frequent ovarian teratoma with frequency of 95.6% (n=973), 2.26% (n=23) being IT and 2.16% (n=22) being MoT. IT were mostly seen in pediatric age group. MT in benign MCT was seen in 0.72% of MCT (n=7). Squamous cell carcinoma was most frequent malignancy 71.4% (n=5). One case of MoT also showed MT into papillary thyroid carcinoma, classic type, with frequency of MT in Mot being 4.76% (n=1). All MT in MCT had age >30 yearswhich was a significant finding (p <0.001).Conclusion: Ovarian masses in postmenopausal patients with suspicious radiological features, irrespective of lesional size warrant a thorough gross examination, extensive sampling and a careful microscopic evaluation.
卵巢畸胎瘤包括成熟囊性畸胎瘤(MCT)、未成熟畸胎瘤(IT)和单皮畸胎瘤(MoT)。恶性转化(MT)可发生在MCT和MoT,这仍然是一个诊断挑战。目的:探讨我院近六年来报告的卵巢畸胎瘤的形态谱,确定MT在MCT和MoT中的频率。研究地点和时间:研究于2015年1月至2020年12月在中台病理研究所进行。材料与方法:对近6年来报道的1018例卵巢畸胎瘤进行回顾性研究。使用SPSS version 20进行数据分析。结果:卵巢畸胎瘤以MCT最为常见,发生率为95.6% (n=973),其中IT占2.26% (n=23), MoT占2.16% (n=22)。多见于儿童年龄组。良性MCT的MT发生率为0.72% (n=7)。鳞状细胞癌是最常见的恶性肿瘤,占71.4% (n=5)。1例MoT也表现为甲状腺乳头状癌,典型型,MoT中发生MT的频率为4.76% (n=1)。MCT中所有MT的年龄均>30岁,这是一个显著的发现(p <0.001)。结论:绝经后卵巢肿块有可疑的放射学特征,无论病变大小,都需要进行彻底的大体检查,广泛的取样和仔细的显微镜评估。
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引用次数: 0
Predictors of Mortality in Necrotizing Soft Tissue Infections in Adults – Experience at A Tertiary Care Hospital in Pakistan 成人坏死性软组织感染的死亡率预测因素——巴基斯坦一家三级医院的经验
Pub Date : 2021-06-26 DOI: 10.47489/pszmc-804-35-3-24-30
H. J. Majid, M. Anwar, M. Z. Khalid, S. Rehman, M. Jameel
Introduction: Necrotizing soft tissue infection is a potentially fatal ‘flesh-eating’ disease that requires prompt intervention to save a patient’s life. Identification of parameters that indicate worsening of the disease (predictors of mortality) is an important part in management that guides a surgeon towards rapid surgical treatment.Aims & Objectives: This retrospective study aims to identify factors that are associated with mortality in adults with NSTIs. This study also aims to propose solutions for the better management of these infection to improve surgical outcome and survival.Place and duration of study: OPD & Emergency of Surgical Unit I and II of Shaikh Zayed Hospital, Lahore over a period of 10 years between the years 2010 to 2021.Material & Methods: This is a cross-sectional epidemiological, retrospective study conducted on patients presenting in the Outpatients Department, as well as the Emergency of Surgical Unit I and II. A total of 72 patients meeting the inclusion criteria were enrolled in this study. SPSS version 23 was used for data analysis.Results: Out of 72 patients, 31.94% of patients were receiving some form of immunosuppressive treatment (n=23), out of which 7 patients lost their life (30.43%, p=0.000). There was a preexisting immunosuppressive disease in 48.61% patients (n=35), and in this subset, a total of 10 patients didn’t recover (28.57%, p=0.000). 13 out of 17 patients who died received first debridement after 12 hours from presentation (p=0.021). High mortality was seen in patients who had the presence of shock at hospital admission.Conclusion: Delay in diagnosis and surgical treatment, the presence of shock at admission accompanied by evidence of organ dysfunction, increasing comorbidity index are reasons for the higher mortality seen in these patients of NSTIs. The timing of the first surgery is of the essence thus highlighting the importance of the “Golden Hour” for the Management of NSTIs.
简介:坏死性软组织感染是一种潜在致命的“食肉性”疾病,需要及时干预以挽救患者的生命。识别表明疾病恶化的参数(死亡率预测因子)是指导外科医生快速手术治疗的重要管理部分。目的和目的:本回顾性研究旨在确定与NSTIs成人死亡率相关的因素。本研究还旨在为更好地管理这些感染提出解决方案,以提高手术效果和生存率。研究地点和时间:拉合尔谢赫扎耶德医院第一和第二外科病房的门诊和急诊,为期10年,从2010年到2021年。材料与方法:本研究是一项横断面流行病学回顾性研究,研究对象为门诊和外科I、II单元急诊科的患者。本研究共纳入72例符合纳入标准的患者。使用SPSS version 23进行数据分析。结果:72例患者中,31.94%的患者接受了某种形式的免疫抑制治疗(n=23),其中7例患者死亡(30.43%,p=0.000)。48.61%的患者(n=35)既往存在免疫抑制疾病,在该亚群中,共有10例患者未康复(28.57%,p=0.000)。17例死亡患者中有13例在发病12小时后接受首次清创(p=0.021)。住院时出现休克的患者死亡率高。结论:诊断和手术治疗的延迟、入院时出现休克并伴有器官功能障碍的证据、合并症指数的增加是NSTIs患者死亡率较高的原因。第一次手术的时机至关重要,因此突出了“黄金时间”对NSTIs管理的重要性。
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引用次数: 0
Community Acquired Methicillin Resistant Staphylococcus Aureus (CA-MRSA) Infection in Paediatric Subcutaneous Abscesses in Pakistan 巴基斯坦儿童皮下脓肿社区获得性耐甲氧西林金黄色葡萄球菌(CA-MRSA)感染
Pub Date : 2021-06-26 DOI: 10.47489/pszmc-802-35-3-12-16
M. A. Sheikh
Introduction: Staphylococcus aureus is one of the common pathogens of the human body. Previously a change in its sensitivity pattern was observed in which it became methicillin resistant but this strain was usually seen in hospital settings or in immunocompromised patients. Recently a changing trend has been observed in which a new variant of methicillin resistant staphylococcus aureus (MRSA) is being isolated specially in pediatric patients, who do not have any risk factors. This strain is labeled as community acquired MRSA.Aims & Objectives: To find the frequency of Community Acquired Methicillin-resistant Staphylococcus Aureus (CAMRSA) in paediatric sub-cutaneous abscesses.Place and duration of study: A cross-sectional prospective study was conducted in Department of Paediatric Surgery Shaikh Zayed Medical Complex, Lahore from January 2017 till December 2020.Material & Methods: All the patients from 7 days to 14 years of age from both genders having subcutaneous abscesses were included. Neonates having hospital stay of more than 24 hours at birth were excluded. Patients having abscess secondary to any surgical intervention, recent hospitalization or trauma were also excluded. Patients were divided into four groups based on age. Pus samples were taken for culture & sensitivity. Data analysis was performed using SPSS version 20.Results: There were 143 patients and 75 (52.4%) of them were males. Patient were divided in groups on the basis of age. The most common location of abscess was head & neck (43.4%) followed by lower limbs and buttocks (30.1%). The most common organism to grow was Staph. aureus (75%) and out of these 107 cases 70 (65.4%) had MRSA. No growth was obtained in 30 (21%) patients. Other less common organisms were seen in 6 (4%) cases. In less than 1 month of age of patients 76% had MRSA which was significantly higher than in other age groups (pvalue 0.047).Conclusion: The frequency of CA-MRSA in paediatric subcutaneous abscesses is on the rise across the globe and more cases of invasive infections are being reported. So, population-based studies are required to assess the prevalence of this bacteria amongst paediatric population of Pakistan.
简介:金黄色葡萄球菌是人体常见的病原体之一。以前观察到其敏感性模式的变化,其中它变得耐甲氧西林,但该菌株通常在医院环境或免疫功能低下的患者中看到。最近观察到一种变化趋势,一种新的耐甲氧西林金黄色葡萄球菌(MRSA)正在被分离出来,特别是在没有任何危险因素的儿科患者中。该菌株被标记为社区获得性MRSA。目的:了解社区获得性耐甲氧西林金黄色葡萄球菌(CAMRSA)在小儿皮下脓肿中的感染频率。研究地点和时间:一项横断面前瞻性研究于2017年1月至2020年12月在拉合尔谢赫扎耶德综合医院儿科外科进行。材料与方法:所有7天至14岁的皮下脓肿患者,男女不限。出生时住院时间超过24小时的新生儿被排除在外。术后继发脓肿、近期住院或外伤的患者也被排除在外。根据年龄将患者分为四组。取脓液样本进行培养和敏感性检测。数据分析采用SPSS version 20。结果:143例患者中男性75例(52.4%)。病人按年龄分组。最常见的脓肿部位为头颈部(43.4%),其次为下肢和臀部(30.1%)。最常见的微生物是葡萄球菌。其中70例(65.4%)为MRSA。30例(21%)患者未见肿瘤生长。在6例(4%)病例中发现了其他不太常见的微生物。在1个月以下的患者中,76%的患者有MRSA,显著高于其他年龄组(p值0.047)。结论:CA-MRSA在儿童皮下脓肿中的发病率在全球范围内呈上升趋势,并且报道了更多的侵袭性感染病例。因此,需要基于人群的研究来评估这种细菌在巴基斯坦儿科人群中的流行程度。
{"title":"Community Acquired Methicillin Resistant Staphylococcus Aureus (CA-MRSA) Infection in Paediatric Subcutaneous Abscesses in Pakistan","authors":"M. A. Sheikh","doi":"10.47489/pszmc-802-35-3-12-16","DOIUrl":"https://doi.org/10.47489/pszmc-802-35-3-12-16","url":null,"abstract":"Introduction: Staphylococcus aureus is one of the common pathogens of the human body. Previously a change in its sensitivity pattern was observed in which it became methicillin resistant but this strain was usually seen in hospital settings or in immunocompromised patients. Recently a changing trend has been observed in which a new variant of methicillin resistant staphylococcus aureus (MRSA) is being isolated specially in pediatric patients, who do not have any risk factors. This strain is labeled as community acquired MRSA.\u0000Aims & Objectives: To find the frequency of Community Acquired Methicillin-resistant Staphylococcus Aureus (CAMRSA) in paediatric sub-cutaneous abscesses.\u0000Place and duration of study: A cross-sectional prospective study was conducted in Department of Paediatric Surgery Shaikh Zayed Medical Complex, Lahore from January 2017 till December 2020.\u0000Material & Methods: All the patients from 7 days to 14 years of age from both genders having subcutaneous abscesses were included. Neonates having hospital stay of more than 24 hours at birth were excluded. Patients having abscess secondary to any surgical intervention, recent hospitalization or trauma were also excluded. Patients were divided into four groups based on age. Pus samples were taken for culture & sensitivity. Data analysis was performed using SPSS version 20.\u0000Results: There were 143 patients and 75 (52.4%) of them were males. Patient were divided in groups on the basis of age. The most common location of abscess was head & neck (43.4%) followed by lower limbs and buttocks (30.1%). The most common organism to grow was Staph. aureus (75%) and out of these 107 cases 70 (65.4%) had MRSA. No growth was obtained in 30 (21%) patients. Other less common organisms were seen in 6 (4%) cases. In less than 1 month of age of patients 76% had MRSA which was significantly higher than in other age groups (pvalue 0.047).\u0000Conclusion: The frequency of CA-MRSA in paediatric subcutaneous abscesses is on the rise across the globe and more cases of invasive infections are being reported. So, population-based studies are required to assess the prevalence of this bacteria amongst paediatric population of Pakistan.","PeriodicalId":20500,"journal":{"name":"Proceedings of Shaikh Zayed Medical Complex Lahore","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76054562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Malus Domestica Peel Extract Counters Carboplatin Induced Fall in Red Blood Cell Count and Bone Marrow Erythroid Cell Percentage in Mice 家葵皮提取物对抗卡铂诱导的小鼠红细胞计数和骨髓红细胞百分比下降
Pub Date : 2021-06-26 DOI: 10.47489/pszmc-803-35-3-17-23
A. M. Rehan
Introduction: The Chemotherapy-Induced Anemia (CIA) is a complex phenomenon impacted by many treatments and patient related variables. Some variations within CIA are type of chemotherapeutic agent, dose and schedule of administration of agent, type as well as stage of cancer, time of intervention, age, gender, nutritional status and renal function. The variety of patient presentation and symptomatology in CIA is very thought-provoking while setting up widespread measures to oversee ideal administration of treatments. This study will be focused on protective role of apple peel extract (APPE) on carboplatin induced fall in blood RBC count bone marrow erythroid cell percentage in mice.Aims & Objective: To evaluate the protective effect of Malus domestica peel extract on carboplatin induced fall in red blood cell count and bone marrow erythroid cell percentage in mice.Place and duration of study: The study was conducted at Pharmacology Department of Postgraduate Medical institute, Lahore in June 2016. The total duration of study was 1 month.Material & Methods: Forty adult male mice were randomly divided into 5 groups (n=8) and maintained on standard diet and water adlibitum. Group A was negative control. Group B was disease control wherein each animal received one dose of 125mg/kg carboplatin intraperitoneally. Group C, D & E experimental groups were administered same dose carboplatin followed by the ethanolic apple peel extract in three different single oral doses of 25, 50 & 75mg/kg respectively for 7 days. Blood & tissue sampling was done on the 8th day. Data was analyzed using Graf Pad prism 7.Results: Acute Carboplatin anaemia resulted in 4.01±0.851012/L RBC Count & 21.6±1.06% bone marrow erythroid cell percentage in Disease Control Group B. Subsequent Apple peel extract administration in a dose of 25, 50 and 75mg/kg countered carboplatin induced fall in Groups C, D & E, simultaneously raising RBC counts & bone marrow erythroid cell percentage to (6.19±0.70×1012/L & 21.3±1.28%) (6.56±0.37×1012/L & 25.3±1.04%) and (6.26±0.74×1012/L & 23.5±1.41%.) respectively. The increase in RBC as well as erythroid cell counts was most significant with the dose of 50mg/kg and nearing that of healthy control levels (Group A)Conclusion: Apple Peel Extract effectively prevented carboplatin induced fall in RBC count and erythroid cellpercentage and produced most significant results in a dose of 50 mg/kg.
化疗性贫血(Chemotherapy-Induced Anemia, CIA)是一个复杂的现象,受多种治疗方法和患者相关变量的影响。CIA的一些变化包括化疗药物的类型、剂量和给药方案、癌症的类型和阶段、干预时间、年龄、性别、营养状况和肾功能。CIA的各种患者表现和症状学非常发人深省,同时建立了广泛的措施来监督理想的治疗管理。本研究旨在探讨苹果皮提取物(apple peel extract, APPE)对卡铂致小鼠红细胞计数、骨髓红细胞百分比下降的保护作用。目的与目的:探讨家苹果皮提取物对卡铂所致小鼠红细胞计数和骨髓红细胞百分比下降的保护作用。研究地点和时间:研究于2016年6月在拉合尔研究生医学研究所药理学部进行。研究总时间为1个月。材料与方法:将40只成年雄性小鼠随机分为5组(n=8),给予标准饮食和饮水。A组为阴性对照。B组为疾病对照,每只动物腹腔注射卡铂125mg/kg 1剂。C组、D组、E组试验组分别以25、50、75mg/kg 3种不同单次口服相同剂量的卡铂,连续7 D。第8天进行血液和组织取样。数据分析采用Graf Pad棱镜7。结果:急性卡铂贫血导致b组红细胞计数为4.01±0.851012/L,骨髓红细胞百分比为21.6±1.06%。随后给予25、50和75mg/kg苹果皮提取物,C、D、E组红细胞计数和骨髓红细胞百分比分别升高至(6.19±0.70×1012/L和21.3±1.28%)(6.56±0.37×1012/L和25.3±1.04%)和(6.26±0.74×1012/L和23.5±1.41%)。当剂量为50mg/kg时,红细胞和红细胞计数的增加最为显著,接近健康对照水平(A组)。结论:苹果皮提取物可有效预防卡铂诱导的红细胞计数和红细胞百分比的下降,且在剂量为50mg/kg时效果最为显著。
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引用次数: 0
Efficacy of Telmisartan in Pristane Induced Arthritis Rat Model 替米沙坦对普里坦性关节炎大鼠模型的影响
Pub Date : 2021-06-26 DOI: 10.47489/pszmc-801-35-3-6-11
Quratulain Mehdi
Introduction: Rheumatoid arthritis is one of the most common systemic inflammatory diseases characterized by progressive damage to the joints. There is rising evidence that Renin Angiotensin Aldosterone System signaling is also involved in the inflammatory response in rheumatoid arthritis and its blockers possess anti-arthritic properties. Telmisartan is an angiotensin receptor blocker and PPAR-? agonist and its anti-arthritic effects were evaluated.Aims & Objectives: This experimental study was designed to evaluate the anti-arthritic efficacy of telmisartan in pristane induced rat model of arthritis in adult female rats.Place and duration of study: The study was conducted in the Department of Pharmacology, Army Medical College, Rawalpindi, in collaboration with National Institute of Health and Armed Forces Institute of Pathology from July 2020to August 2020.Material & Methods: Twenty four (24) adult non-pregnant female Sprague Dawley rats were divided in three groups (n=8) designated as Group A (normal control), Group B (arthritic control) and Group C (telmisartan group) & maintained on standard diet and water adlibitum. Rheumatoid arthritis was induced in each rat of Groups B &C by a single intradermal injection of 0.5ml pristane at the base of its tail on day 0 and the disease developed in two weeks. All3 groups were given distilled water 2.5 ml/kg from 2-4 weeks and Group C was additionally given dissolved telmisartan orally at 2 mg/kg/day. Anti-arthritic efficacy was determined by assessing arthrogram score and total leukocyte count on day 0, 14 and 28 along with histological examination done at the end of the study. Data analysis was done using SPSS version 25.Results: Healthy rats in group A maintained a unremarkable arthogram & histogram score & TLC count of 6675±350/?l during the entire study period. Telmisartan administration in Group C for two weeks after pristane induction resulted in significant reduction in arthrogram score (AS) 9.5±3.66, total leukocyte count (TLC) 7350±550/?l and histological score (HS) to 6.88±1.24 as compared to (AS) 14.50±2.07, WBC 10150±350/?L & (HS) 10.75±2.05 in Group B, left untreated with pristane alone. The intergroup comparison showed significant p value < 0.05 respectively.Conclusion: Anti-arthritic effect was shown by telmisartan as it was able to ameliorate the changes induced by pristane.
类风湿关节炎是最常见的系统性炎症性疾病之一,其特征是关节的进行性损伤。越来越多的证据表明肾素血管紧张素醛固酮系统信号也参与类风湿关节炎的炎症反应,其阻滞剂具有抗关节炎的特性。替米沙坦是一种血管紧张素受体阻断剂和PPAR-?评价激动剂及其抗关节炎作用。目的:本实验旨在评价替米沙坦对普里斯坦诱导的成年雌性大鼠关节炎模型的抗关节炎作用。研究地点和时间:该研究于2020年7月至2020年8月在拉瓦尔品第陆军医学院药学系与国家卫生研究所和武装部队病理研究所合作进行。材料与方法:将24只成年未孕雌性Sprague Dawley大鼠分为A组(正常对照组)、B组(关节炎对照组)和C组(替米沙坦组)3组(n=8),给予标准饮食和饮水。B、c组大鼠于第0天尾底单次皮下注射普利斯坦0.5ml诱导类风湿关节炎,2周发病。3组均于2 ~ 4周给予蒸馏水2.5 ml/kg, C组在此基础上口服溶解替米沙坦2 mg/kg/d。通过评估关节造影评分和第0、14和28天的总白细胞计数以及研究结束时的组织学检查来确定抗关节炎疗效。数据分析采用SPSS 25。结果:A组健康大鼠的直方图评分和TLC计数均维持在6675±350/?L在整个研究期间。C组替米沙坦在普里斯坦诱导后给予2周,关节图评分(AS) 9.5±3.66,总白细胞计数(TLC) 7350±550/?组织学评分(HS)为6.88±1.24,而as为14.50±2.07,WBC为10150±350/?B组L & (HS) 10.75±2.05,单药不给药。组间比较p值均< 0.05。结论:替米沙坦能改善普里斯坦引起的关节炎,具有抗关节炎作用。
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引用次数: 0
Prevalence of Right Ventricular Dysfunction & Pulmonary Hypertension and their Relationship to the Number of Hemodialysis Sessions in Patients of End-Stage Renal Disease (ESRD) 终末期肾病(ESRD)患者右室功能障碍、肺动脉高压患病率及其与血液透析次数的关系
Pub Date : 2021-06-26 DOI: 10.47489/pszmc-811-35-3-64-68
R. B. Adhikari
Introduction: Chronic hemodialysis (HD) ends up with right ventricular (RV) dysfunction and increased pulmonary hypertension (PHTN). Left to right shunt in dialysis patients due to arterio-venous fistula (AVF) causes chronic volume overload, independent of rise in body water leading to worsening RV overload and RV dysfunction (RVD).Aims & Objectives: To determine the prevalence of RV dysfunction & pulmonary hypertension and its relationship to the number of dialysis sessions in patients of ESRD.Place and duration of study: Department of Cardiology & Nephrology, Sheikh Zayed Hospital, Lahore for one year from March 2016 - March 2017.Material & Methods: This cross-sectional analytical hospital based study enrolled 145 Patients of End-Stage Renal Disease (ESRD) on regular 4-hours HD sessions at two or more times per week for at least 3 months. Echocardiography(Echo) with 2-D, M (Motion) Mode & Doppler studies were done. RV dysfunction by TAPSE value less than 15mm & PHTN by Systolic pulmonary artery pressure >35 mm Hg or tricuspid regurgitation velocity (VTR) ?2m/s at rest were noted. Data was analyzed on SPSS version 20.Results: RV dysfunction was seen in 40.7% (59) of patients and the frequency rose across the 4 dialysis session groups (13.8%, 37.3%, 51.7% & 100%, p<0.001). PHTN was observed in 44.1% of the patients and the prevalence progressively increased across the groups (17.2%, 45.1%, 53.3% & 80.01%, p<0.003). There was significant association between RVD and PHTN (p=0.011).Conclusion: We observed positive correlation between RV dysfunction and PHTN with total number of hemodialysis sessions. Early detection of sub-clinical RV dysfunction may improve mortality and morbidity by optimizing treatment options.
慢性血液透析(HD)最终导致右心室(RV)功能障碍和肺动脉高压(PHTN)升高。由动静脉瘘(AVF)引起的透析患者左向右分流导致慢性容量过载,而与体内水分升高无关,导致右心室过载和右心室功能障碍(RVD)恶化。目的:了解终末期肾病患者右心室功能障碍和肺动脉高压的患病率及其与透析次数的关系。学习地点和时间:2016年3月至2017年3月,拉合尔Sheikh Zayed医院心脏病和肾脏病科,为期一年。材料与方法:这项以医院为基础的横断面分析性研究招募了145名终末期肾病(ESRD)患者,每周两次或更多次定期进行4小时HD治疗,持续至少3个月。2-D超声心动图(Echo)、运动模式及多普勒检查。以TAPSE值小于15mm为右心室功能障碍,以肺动脉收缩压小于35mm Hg或静止时三尖瓣反流速度(VTR) ?2m/s为PHTN。数据采用SPSS version 20进行分析。结果:40.7%(59)的患者出现右心室功能障碍,并且在4个透析疗程组中频率升高(13.8%,37.3%,51.7%和100%,p<0.001)。PHTN发生率为44.1%,各组间呈递增趋势(17.2%、45.1%、53.3%、80.01%,p<0.003)。RVD与PHTN有显著相关性(p=0.011)。结论:RV功能障碍和PHTN与血液透析总次数呈正相关。早期发现亚临床右心室功能障碍可以通过优化治疗方案来提高死亡率和发病率。
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引用次数: 0
Prevalence of Bacterial Vaginosis During Pregnancy in Tertiary Care Hospital, Lahore 拉合尔三级保健医院妊娠期细菌性阴道病的患病率
Pub Date : 2021-06-26 DOI: 10.47489/pszmc-808-35-3-50-53
A. Javed, M. Ikram, S. Mukhtar, S. Sarfraz, A. Shahid, A. Rehman
Introduction: Pregnancy is a condition usually associated with increased vaginal discharge including vaginal infections like bacterial vaginosis, leading to adverse perinatal outcomes due to disturbance in vaginal ecosystem that warrants further evaluation and timely management.Aims & Objectives: The study was conducted to determine the prevalence of bacterial vaginosis in pregnancy and its contributing factors.Place and duration of study: Out Patient Department of Obstetrics & Gynecology, Shaikh Zayed Hospital, Lahore. Duration of the study was six months.Material & Methods: 120 pregnant females with age 20-40 years with singleton pregnancy of more than 12 weeks’ gestation were included. Women who were immunosuppressed and history of diabetes and hypertension and recent history of use of antibiotics were excluded. Vaginal swab specimen was taken & bacterial vaginosis was labelled after fulfilling Amsel criteria. Data was analyzed using SPSS version 21.Results: In this study, 120 cases were taken and mean age of participants was 27.55±3.97 years. The mean duration of gestation was 18.76±6.14 weeks. Bacterial vaginosis (BV) was seen in 24 (20%) of the cases. BV was seen in 19 (20.65%) cases with age 20-29 years’ vs 5 (17.86%) cases in age group 20-40 years with p= 1.0. Bacterial vaginosis was nearly significantly high in multiparous women where this was seen in 13 (27.65%) cases as compared to 11 (15.06%)cases in primiparous women with p= 0.11. Out of 20 cases of bacterial vaginosis, low education was seen in 12 (60%) of the cases.Conclusion: The prevalence of bacterial vaginosis in pregnancy at local setup is high and is seen nearly in 1 out of 5 cases. This demands health educational programs to enlighten women regarding screening and early detection & treatment to prevent complications during pregnancy.
妊娠通常与阴道分泌物增加有关,包括细菌性阴道病等阴道感染,由于阴道生态系统紊乱,导致围产期不良结局,需要进一步评估和及时处理。目的:本研究旨在确定妊娠期细菌性阴道病的患病率及其影响因素。研究地点和时间:拉合尔谢赫扎耶德医院妇产科门诊部。研究时间为6个月。材料与方法:选取年龄20 ~ 40岁单胎妊娠12周以上的孕妇120例。排除免疫抑制、有糖尿病、高血压史和近期使用抗生素史的妇女。取阴道拭子标本,满足Amsel标准后标记细菌性阴道病。数据分析采用SPSS version 21。结果:本研究共纳入病例120例,平均年龄27.55±3.97岁。平均妊娠期为18.76±6.14周。细菌性阴道病(BV) 24例(20%)。20 ~ 29岁组BV 19例(20.65%),20 ~ 40岁组BV 5例(17.86%),p= 1.0。细菌性阴道病在多产妇女中几乎是非常高的,13例(27.65%),而在初产妇女中有11例(15.06%),p= 0.11。在20例细菌性阴道病中,有12例(60%)受教育程度低。结论:局部妊娠期细菌性阴道病患病率高,近1 / 5。这就要求开展健康教育项目,对妇女进行筛查、早期发现和治疗,以预防怀孕期间的并发症。
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引用次数: 0
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Proceedings of Shaikh Zayed Medical Complex Lahore
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