Pub Date : 2021-06-26DOI: 10.47489/pszmc-809-35-3-54-57
Asifa Karamat
Introduction: Chronic Obstructive Pulmonary Disease (COPD) is a high burden respiratory issue all over the world. It has high morbidity and mortality in the United States. Bronchiectasis is associated with chronic obstructive pulmonary disease (COPD) and is under diagnosed as diagnostic tools like HRCT though easily available but an expensive test in developing countries like Pakistan. We aim to establish the frequency and patterns of bronchiectasis in patients of COPD. Aims and Objectives: To establish the frequency and pattern of bronchiectasis in COPD in our population so that we can improve patient care and quality of life of these patients. Place and duration of study: We did a cross sectional survey in Department of Pulmonology, Gulab Devi Hospital, Lahore. Study was completed from 1st September 2017 to 28th February 2018. Material & Methods: After taking an informed consent 150 already diagnosed COPD patients were included. Bronchiectasis was seen on high resolution CT scan (HRCT). Data was collected on a structured proforma and analyzed on SPSS version 20. Results: Bronchiectasis was observed in 76 (50.6%) patients of COPD while 74 patients had no bronchiectasis. Out of 76, cylindrical bronchiectasis was seen in 82%. Lower lobe and bilateral involvement was more common. Means of age, gender, exacerbations of COPD, and history of pulmonary tuberculosis were not related to bronchiectasis while pack years of smoking, duration of illness and Modified Medical Research Council (MMRC) Dyspnea Scale were significantly related to bronchiectasis. Conclusion: This is observed that bronchiectasisis quite common (50.6%) in patients of COPD in our population.
慢性阻塞性肺疾病(COPD)是一种世界性的高负担呼吸系统疾病。它在美国有很高的发病率和死亡率。支气管扩张与慢性阻塞性肺疾病(COPD)有关，在巴基斯坦等发展中国家，虽然HRCT等诊断工具很容易获得，但却很昂贵。我们的目的是建立慢性阻塞性肺病患者支气管扩张的频率和模式。目的:研究慢性阻塞性肺病患者支气管扩张的频率和模式，以改善患者的护理和生活质量。研究地点和时间:我们在拉合尔Gulab Devi医院肺病科进行了横断面调查。研究于2017年9月1日至2018年2月28日完成。材料与方法:在知情同意后，纳入了150名已经诊断为COPD的患者。高分辨率CT扫描(HRCT)显示支气管扩张。数据以结构化形式表收集，并使用SPSS version 20进行分析。结果:慢性阻塞性肺病患者支气管扩张76例(50.6%)，无支气管扩张74例。在76例患者中，柱状支气管扩张占82%。下肺叶及双侧受累更为常见。年龄、性别、COPD加重程度和肺结核史与支气管扩张无关，而吸烟年数、患病时间和改良医学研究委员会(MMRC)呼吸困难量表与支气管扩张显著相关。结论:观察到支气管扩张在我国COPD患者中相当常见(50.6%)。
{"title":"Frequency and Pattern of Bronchiectasis in Patients with Chronic Obstructive Pulmonary Disease Presenting in a Tertiary Care Hospital","authors":"Asifa Karamat","doi":"10.47489/pszmc-809-35-3-54-57","DOIUrl":"https://doi.org/10.47489/pszmc-809-35-3-54-57","url":null,"abstract":"Introduction: Chronic Obstructive Pulmonary Disease (COPD) is a high burden respiratory issue all over the world. It has high morbidity and mortality in the United States. Bronchiectasis is associated with chronic obstructive pulmonary disease (COPD) and is under diagnosed as diagnostic tools like HRCT though easily available but an expensive test in developing countries like Pakistan. We aim to establish the frequency and patterns of bronchiectasis in patients of COPD.\u0000Aims and Objectives: To establish the frequency and pattern of bronchiectasis in COPD in our population so that we can improve patient care and quality of life of these patients.\u0000Place and duration of study: We did a cross sectional survey in Department of Pulmonology, Gulab Devi Hospital, Lahore. Study was completed from 1st September 2017 to 28th February 2018.\u0000Material & Methods: After taking an informed consent 150 already diagnosed COPD patients were included. Bronchiectasis was seen on high resolution CT scan (HRCT). Data was collected on a structured proforma and analyzed on SPSS version 20.\u0000Results: Bronchiectasis was observed in 76 (50.6%) patients of COPD while 74 patients had no bronchiectasis. Out of 76, cylindrical bronchiectasis was seen in 82%. Lower lobe and bilateral involvement was more common. Means of age, gender, exacerbations of COPD, and history of pulmonary tuberculosis were not related to bronchiectasis while pack years of smoking, duration of illness and Modified Medical Research Council (MMRC) Dyspnea Scale were significantly related to bronchiectasis.\u0000Conclusion: This is observed that bronchiectasisis quite common (50.6%) in patients of COPD in our population.","PeriodicalId":20500,"journal":{"name":"Proceedings of Shaikh Zayed Medical Complex Lahore","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89768836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-26DOI: 10.47489/pszmc-812-35-3-69-74
Hira Ashfaq
Introduction: In today’s world of science and medicine, assessing ones’ quality of life has become a norm. It provides baseline information for future planning in order to elevate quality of life of individuals and communities. Aims & Objectives: To assess the quality of life of infertile women and identify factors influencing it. Place and duration of study: Data was collected from Lahore General Hospital and Services Institute of Medical Sciences, Lahore during 2019. Material & Methods: A cross-sectional study was conducted on 260 married, infertile females attending infertility clinics of two tertiary care hospitals of Lahore. 36-items FertiQoL, an Urdu validated version was used to assess the quality of life of females with infertility. It had six subscales and three total scores. Data was analyzed through SPSS version 22. Results: Mean age of females was found to be 30+5.23 years and 85.8% were not working women. Average duration of infertility was 6.7 years. 61.5% of females presented with primary infertility. 70.4% reported positive attitude of their husband towards this infertility while 56.2% of the participants reported positive attitude of their in-laws as well. 30.8% of the females rated their health as poor. 31.2% reported to be dissatisfied with their overall quality of life. In FertiQoL, ‘Emotional’ subscale showed mean 67±14 SD, ‘Mind-body’ subscale mean 69±14 SD, ‘Relational’ subscale mean 55±14.7 SD, ‘Social’ subscale mean 66.2±14.5 SD, ‘Treatment Environment’ mean 70±17.5 SD and ‘treatment tolerability’ showed mean of 73±17.2 SD. ‘Total scaled core score’ showed mean of 64.5±12 SD, ‘total scaled treatment score’ mean of 69.3±14 SD and ‘total scored FertiQoL score’ showed mean of 66±12 SD. Significant association between family income and mind body subscale; duration of marriage and treatment tolerability; time till infertility diagnosis and treatment environment was found. While overall FertiQoL score and Family Income was found to be significantly associated. Conclusion: Overall quality of life of infertile females is not compromised as was thought of except for its association with family income. Sub scales of mind-body, treatment tolerability and treatment environment were found to be associated with family income, duration of marriage and time till infertility diagnosis respectively. Recognition of factors associated with poor quality of life will help in planning strategies to overcome them during infertility treatment.
{"title":"Fertility-Related Quality of Life Amongst Married Infertile Females of Lahore","authors":"Hira Ashfaq","doi":"10.47489/pszmc-812-35-3-69-74","DOIUrl":"https://doi.org/10.47489/pszmc-812-35-3-69-74","url":null,"abstract":"Introduction: In today’s world of science and medicine, assessing ones’ quality of life has become a norm. It provides baseline information for future planning in order to elevate quality of life of individuals and communities.\u0000Aims & Objectives: To assess the quality of life of infertile women and identify factors influencing it. \u0000Place and duration of study: Data was collected from Lahore General Hospital and Services Institute of Medical Sciences, Lahore during 2019.\u0000Material & Methods: A cross-sectional study was conducted on 260 married, infertile females attending infertility clinics of two tertiary care hospitals of Lahore. 36-items FertiQoL, an Urdu validated version was used to assess the quality of life of females with infertility. It had six subscales and three total scores. Data was analyzed through SPSS version 22.\u0000Results: Mean age of females was found to be 30+5.23 years and 85.8% were not working women. Average duration of infertility was 6.7 years. 61.5% of females presented with primary infertility. 70.4% reported positive attitude of their husband towards this infertility while 56.2% of the participants reported positive attitude of their in-laws as well. 30.8% of the females rated their health as poor. 31.2% reported to be dissatisfied with their overall quality of life. In FertiQoL,\u0000‘Emotional’ subscale showed mean 67±14 SD, ‘Mind-body’ subscale mean 69±14 SD, ‘Relational’ subscale mean 55±14.7 SD, ‘Social’ subscale mean 66.2±14.5 SD, ‘Treatment Environment’ mean 70±17.5 SD and ‘treatment tolerability’ showed mean of 73±17.2 SD. ‘Total scaled core score’ showed mean of 64.5±12 SD, ‘total scaled treatment score’ mean of 69.3±14 SD and ‘total scored FertiQoL score’ showed mean of 66±12 SD. Significant association between family income and mind body subscale; duration of marriage and treatment tolerability; time till infertility diagnosis and treatment environment was found. While overall FertiQoL score and Family Income was found to be significantly associated.\u0000Conclusion: Overall quality of life of infertile females is not compromised as was thought of except for its association with family income. Sub scales of mind-body, treatment tolerability and treatment environment were found to be associated with family income, duration of marriage and time till infertility diagnosis respectively. Recognition of factors associated with poor quality of life will help in planning strategies to overcome them during infertility treatment.","PeriodicalId":20500,"journal":{"name":"Proceedings of Shaikh Zayed Medical Complex Lahore","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81479468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-26DOI: 10.47489/pszmc-814-35-3-78-80
S. Shah
Hereditary Multiple Exostoses is a skeletal dysplasia that is very rare and defined by formation of numerous cartilage capped benign tumours either pedunculated or sessile known as osteochondromas throughout skeleton especially around the growth plates of ribs, vertebrae, pelvis and long bones. Rarely it can present forearm problems such bowing deformity of radius, ulnar shortening and radiocapitellar dislocation or subluxation. We are presenting a case of 20 year old female who presented with left distal ulnar exostosis resulting in ulnar shortening and radial bowing with restricted supination and pronation range of movement. Other complaint was of multiple non tender bony hard lumps in both upper and lower limbs. Excision of distal ulnar exostosis was done which resulted in marked improvement in pronation and supination range of movement. Hereditary multiple exostoses with forearm deformities though very rare but can present and the treatment is conservative except if any bony swelling manifests any complications such as pain or associated deformity.
{"title":"Hereditary Multiple Exostoses with Ulnar Hemimelia","authors":"S. Shah","doi":"10.47489/pszmc-814-35-3-78-80","DOIUrl":"https://doi.org/10.47489/pszmc-814-35-3-78-80","url":null,"abstract":"Hereditary Multiple Exostoses is a skeletal dysplasia that is very rare and defined by formation of numerous cartilage capped benign tumours either pedunculated or sessile known as osteochondromas throughout skeleton especially around the growth plates of ribs, vertebrae, pelvis and long bones. Rarely it can present forearm problems such bowing deformity of radius, ulnar shortening and radiocapitellar dislocation or subluxation. We are presenting a case of 20 year old female who presented with left distal ulnar exostosis resulting in ulnar shortening and radial bowing with restricted supination and pronation range of movement. Other complaint was of multiple non tender bony hard lumps in both upper and lower limbs. Excision of distal ulnar exostosis was done which resulted in marked improvement in pronation and supination range of movement. Hereditary multiple exostoses with forearm deformities though very rare but can present and the treatment is conservative except if any bony swelling manifests any complications such as pain or associated deformity.","PeriodicalId":20500,"journal":{"name":"Proceedings of Shaikh Zayed Medical Complex Lahore","volume":"169 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85831189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-26DOI: 10.47489/pszmc-810-35-3-58-63
Sadia Majeed
Introduction: Hepatotoxicity induced by anti-tuberculous medicine is known due to their oxidative stress. Ajwa dates may have a role to protect liver from oxidative stress Aims & Objectives: To assess the preventive effect of Ajwa date on hepatotoxicity induced by anti-tuberculous drugs in rabbits. Place and duration of study: Post Graduate Medical Institute, Lahore for three months, from May 2014 to July 2014. Material & Methods: Thirty rabbits were distributed into five groups. Rabbits of Group A and of B were fed on normal diet in form of pellets. Group C, D and E were provided diet containing one whole Ajwa date, flesh of one Ajwa date and powdered seed of one Ajwa date respectively in each 100 grams of diet throughout study. Group B, C, D and E were administered 50mg/kg isoniazid and 100mg/kg rifampicin orally for 14 days. Serum levels of liver enzymes Alanine transaminase (ALT), Aspartate transaminase (AST) and Alkaline phosphatase (ALP) and bilirubin were estimated on day 0 and 14. One way ANOVA followed by post hoc Tukey’s test and t-test were applied for statistical analysis using SPSS 20. Results: Baseline LFTs were normal in all groups. Significant hepatotoxicity was observed after 2weeks of INH and rifampicin administration in disease control group B (ALT 200.2±19.3 & ALP 231.0±21.3 IU/L, AST 139.0±22 & bilirubin 0.48±0.046mg/dl, (p value < 0.001) as compared to healthy control group A (ALT47.2 ± 6.7 & ALP78.2 ±5.0 IU/L, AST 43.0 ± 9.7, bilirubin 0.10± 0.00mg/dl). (p value < 0.001). Concomitant Ajwa intake during the same period resulted in an equipotent significantly similar improvement in LFTs in Groups C (whole date) ALT55.7 ± 4.7&ALP 91.5 ±5.0IU/L, AST, 59.0 ± 15.3 &bilirubin 0.09 ±0.02 mg/dl): D (flesh) ALT89.8 ± 6.3 & ALP111.3 ±9.4 IU/L, AST73.7 ± 8.3 & bilirubin0.12± 0.04 mg/dl & E (seed powder) ALT85.8 ± 8.6 IU/L &ALP 92.8 ±11.4 IU/L, AST57.5 ± 5.3 & bilirubin 0.12 ±0.04 mg/dl) versus group B (p value < 0.001). and near normalization of liver function close to that of healthy control group Conclusion: Co-administration of Ajwa date whole fruit, flesh and seed powder are equipotent and effective in preventing isoniazid and rifampicin induced hepatotoxicity.
{"title":"Phoenix dactylifera (Ajwa Date) Whole Fruit, Flesh and Powdered Seed Prevents Anti-Tuberculous Drug Induced Hepatotoxicity in Rabbits","authors":"Sadia Majeed","doi":"10.47489/pszmc-810-35-3-58-63","DOIUrl":"https://doi.org/10.47489/pszmc-810-35-3-58-63","url":null,"abstract":"Introduction: Hepatotoxicity induced by anti-tuberculous medicine is known due to their oxidative stress. Ajwa dates may have a role to protect liver from oxidative stress\u0000Aims & Objectives: To assess the preventive effect of Ajwa date on hepatotoxicity induced by anti-tuberculous drugs in rabbits.\u0000Place and duration of study: Post Graduate Medical Institute, Lahore for three months, from May 2014 to July 2014.\u0000Material & Methods: Thirty rabbits were distributed into five groups. Rabbits of Group A and of B were fed on normal diet in form of pellets. Group C, D and E were provided diet containing one whole Ajwa date, flesh of one Ajwa date and powdered seed of one Ajwa date respectively in each 100 grams of diet throughout study. Group B, C, D and E were administered 50mg/kg isoniazid and 100mg/kg rifampicin orally for 14 days. Serum levels of liver enzymes Alanine\u0000transaminase (ALT), Aspartate transaminase (AST) and Alkaline phosphatase (ALP) and bilirubin were estimated on day 0 and 14. One way ANOVA followed by post hoc Tukey’s test and t-test were applied for statistical analysis using SPSS 20.\u0000Results: Baseline LFTs were normal in all groups. Significant hepatotoxicity was observed after 2weeks of INH and rifampicin administration in disease control group B (ALT 200.2±19.3 & ALP 231.0±21.3 IU/L, AST 139.0±22 & bilirubin 0.48±0.046mg/dl, (p value < 0.001) as compared to healthy control group A (ALT47.2 ± 6.7 & ALP78.2 ±5.0 IU/L, AST 43.0 ± 9.7, bilirubin 0.10± 0.00mg/dl). (p value < 0.001). Concomitant Ajwa intake during the same period resulted in an equipotent significantly similar improvement in LFTs in Groups C (whole date) ALT55.7 ± 4.7&ALP 91.5 ±5.0IU/L, AST, 59.0 ± 15.3 &bilirubin 0.09 ±0.02 mg/dl): D (flesh) ALT89.8 ± 6.3 & ALP111.3 ±9.4 IU/L, AST73.7 ± 8.3 & bilirubin0.12± 0.04 mg/dl & E (seed powder) ALT85.8 ± 8.6 IU/L &ALP 92.8 ±11.4 IU/L, AST57.5 ± 5.3 &\u0000bilirubin 0.12 ±0.04 mg/dl) versus group B (p value < 0.001). and near normalization of liver function close to that of healthy control group\u0000Conclusion: Co-administration of Ajwa date whole fruit, flesh and seed powder are equipotent and effective in preventing isoniazid and rifampicin induced hepatotoxicity.","PeriodicalId":20500,"journal":{"name":"Proceedings of Shaikh Zayed Medical Complex Lahore","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87816396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-26DOI: 10.47489/pszmc-813-35-3-75-77
Wajida Perveen
Facial nerve palsy is a common condition affecting both genders and all age group. However, its incidence in pregnant females needs greater care. It may affect only lower half of the face or full one side of the face or in extreme condition bilateral sides. Symptoms include deviation of angle of mouth towards sound side, flattening of nasolabial folds, loss of forehead wrinkles and inability to completely close the eyelid along with loss of taste on anterior two third of tongue. Here we present a rare case report of facial nerve palsy in a pregnant woman in third trimester of pregnancy. She was offered an evidence based physiotherapy treatment regime along with pharmacological treatment and she recovered; however late complication of “Ptosis” was reported.
{"title":"Idiopathic Facial Nerve Paralysis & Response to Physiotherapy in Pregnant Woman; A Case Report","authors":"Wajida Perveen","doi":"10.47489/pszmc-813-35-3-75-77","DOIUrl":"https://doi.org/10.47489/pszmc-813-35-3-75-77","url":null,"abstract":"Facial nerve palsy is a common condition affecting both genders and all age group. However, its incidence in pregnant females needs greater care. It may affect only lower half of the face or full one side of the face or in extreme condition bilateral sides. Symptoms include deviation of angle of mouth towards sound side, flattening of nasolabial folds, loss of forehead wrinkles and inability to completely close the eyelid along with loss of taste on anterior two third of tongue. Here we present a rare case report of facial nerve palsy in a pregnant woman in third trimester of pregnancy. She was offered an evidence based physiotherapy treatment regime along with pharmacological treatment and she recovered; however late complication of “Ptosis” was reported.","PeriodicalId":20500,"journal":{"name":"Proceedings of Shaikh Zayed Medical Complex Lahore","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86189398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-26DOI: 10.47489/pszmc-800-35-3-1-5
Fariha Sahrish
Introduction: Pediatric renal tumors constitute 7 to 8% of pediatric solid malignancies and most common is Wilms tumor. It usually presents as unilateral mass with sporadic and familial associations. It is currently treated by NWTS and SIOP protocols worldwide. In our hospital setup we follow SIOP 2001 protocol to subcategorize different histological subtypes and staging of Wilms tumor after completing four cycles of chemotherapy. Aims & Objectives: To determine the frequency of histological subtypes of Wilms tumor (WT) in post chemotherapy nephrectomy specimens Place and duration of study: Histopathology Section of Pathology Department, Children’s Hospital and Institute of Child Health Lahore from January 2015 to June 2018. Material & Methods: Ninety-three radical nephrectomy specimens of different histological subtypes i.e. Wilms Tumor (WT) consisting of blastemal predominant (BP), epithelial predominant (EP), stromal (ST), mixed (MT), regressive (RP), completely necrotic (CN) and diffuse anaplastic (DA) were analyzed. Risk categorization and staging proposed by SIOP 2001 was appraised. Data analysis was done using SPSS version 23. Results: A total of 93 cases were included in the present study. Mean age of children recorded was 42 months with male predominance. Mean tumor size after chemotherapy was 7.25 cm. Majority cases were observed on the right side. Regarding the histological subtype there was a predominant group of MT while least observed was DA. Based on subtypes and necrosis, majority of WT were of intermediate risk (IR) and stage I tumors. Conclusion: Majority of pretreated cases (n=80, 85.1%) were stage 1 tumors. Commonest histological subtype is MT followed by RP, CN, EP, BP, ST and DA.
儿童肾肿瘤占儿童实体恶性肿瘤的7 - 8%，最常见的是肾母细胞瘤。它通常表现为单侧肿块，偶有散发和家族性关联。目前在世界范围内采用NWTS和SIOP协议进行治疗。在我们的医院设置中，我们遵循SIOP 2001协议对完成四个周期化疗后的Wilms肿瘤进行不同组织学亚型和分期的亚分类。目的和目的:确定化疗后肾切除术标本中Wilms肿瘤(WT)组织学亚型的频率。研究地点和时间:2015年1月至2018年6月拉合尔儿童医院病理科和儿童保健研究所组织病理学组。材料与方法:对93例不同组织学亚型肾母细胞瘤(WT)的根治性肾切除术标本进行分析，包括胚质优势型(BP)、上皮优势型(EP)、基质型(ST)、混合型(MT)、退行性(RP)、完全坏死型(CN)和弥漫性间变性(DA)。对SIOP 2001提出的风险分类和分期进行评价。数据分析使用SPSS version 23。结果:本研究共纳入93例。患儿平均年龄42个月，男性居多。化疗后平均肿瘤大小为7.25 cm。多数病例位于右侧。在组织学亚型上，以MT为主，DA最少。根据亚型和坏死程度，大多数WT为中等风险(IR)和I期肿瘤。结论:绝大多数(80例，85.1%)为1期肿瘤。最常见的组织学亚型为MT，其次为RP、CN、EP、BP、ST和DA。
{"title":"Histological Subtypes & Staging of Post-Chemotherapy Wilms Tumor According to SIOP 2001 Protocol: Study at the Children’s Hospital, Lahore","authors":"Fariha Sahrish","doi":"10.47489/pszmc-800-35-3-1-5","DOIUrl":"https://doi.org/10.47489/pszmc-800-35-3-1-5","url":null,"abstract":"Introduction: Pediatric renal tumors constitute 7 to 8% of pediatric solid malignancies and most common is Wilms tumor. It usually presents as unilateral mass with sporadic and familial associations. It is currently treated by NWTS and SIOP protocols worldwide. In our hospital setup we follow SIOP 2001 protocol to subcategorize different histological subtypes and staging of Wilms tumor after completing four cycles of chemotherapy.\u0000Aims & Objectives: To determine the frequency of histological subtypes of Wilms tumor (WT) in post chemotherapy nephrectomy specimens\u0000Place and duration of study: Histopathology Section of Pathology Department, Children’s Hospital and Institute of Child Health Lahore from January 2015 to June 2018.\u0000Material & Methods: Ninety-three radical nephrectomy specimens of different histological subtypes i.e. Wilms Tumor (WT) consisting of blastemal predominant (BP), epithelial predominant (EP), stromal (ST), mixed (MT), regressive (RP), completely necrotic (CN) and diffuse anaplastic (DA) were analyzed. Risk categorization and staging proposed by SIOP 2001 was appraised. Data analysis was done using SPSS version 23.\u0000Results: A total of 93 cases were included in the present study. Mean age of children recorded was 42 months with male predominance. Mean tumor size after chemotherapy was 7.25 cm. Majority cases were observed on the right side. Regarding the histological subtype there was a predominant group of MT while least observed was DA. Based on subtypes and necrosis, majority of WT were of intermediate risk (IR) and stage I tumors.\u0000Conclusion: Majority of pretreated cases (n=80, 85.1%) were stage 1 tumors. Commonest histological subtype is MT followed by RP, CN, EP, BP, ST and DA.","PeriodicalId":20500,"journal":{"name":"Proceedings of Shaikh Zayed Medical Complex Lahore","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73602579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-26DOI: 10.47489/pszmc-806-35-3-37-43
S. Komal, Aqna Malik, N. Akhtar, S. A. J. Kazmi, F. Anjum, A. Rida
Introduction: Hepatic diseases remain the leading cause of death worldwide. Despite overall advancements in health care, mortality due to hepatic diseases is constantly growing. More than 2 million people globally are estimated to die each year from liver diseases, and current treatment offers little for its management. Thus, it is essential to find more effective and less toxic pharmaceutical alternatives for the treatment of liver diseases. Aims & Objectives: Tamarix dioica, a shrub broadly used in herbal medicine for the treatment and prevention of various diseases. The current study was designed to analyze the hepatoprotective effect of T. dioica in BALB?cmice against CCl4-induced acute liver damage. Place and duration of study: The study was conducted in NIH, Islamabad, Pakistan, for six months in 2016-2017. Material & Methods: For in vivo evaluation, the animals (n= 42) were randomly divided into seven groups (n=6), three control (i.e. Group, I or normal control, group II or induction control received 0.9% normal saline orally, and Group III or positive control received silymarin 100 mg/kg per oral), and four treatment groups (i.e. IV, V,VI and VII were treated with oral T.dioica 200 mg/kg/day, 300mg/kg/day methanol extract, 200mg/kg/day and 300mg/kg/day of aqueous extracts respectively for six days, followed by intraperitoneal administration of CCl4 on the seventh day. The blood samples were collected for analysis of LFTs, and hepatic tissue was taken for histological analysis. Data was analyzed using SPSS version 16, one-way ANOVA with Duncan’s Multiple Range Test (DMRT). Results: CCl4 induction in Group 2 resulted in severe hepatic derangement manifested as highly elevated mean LFTs (ALT 7245.56, AST 3292.11, ALP 340.09 U/L, bilirubin 4.64 mg/dl) as compared to healthy controls (ALT 38.97, AST 50.20, ALP 57.17 U/L, bilirubin 1.25 mg/dl: (Group 1) levels p<0.001. Pretreatment with different extracts of T.dioica for 6 days before CCl4 administration produced varying degrees of hepatoprotection. 300mg/kg aqueous extract T.dioica (Group7) prevented damage with maximal hepatoprotection, reduced LFTs (ALT: 339.95 , AST: 242.90 , ALP: 116.86 U/L, bilirubin: 1.38 mg/dl) and normalized liver histology as compared to Group 2 and standard drug silymarin 100mg/kg, (ALT: 6483.23, AST: 2567.69, ALP: 272.19 U/L, bilirubin: 2.84 mg/dl: Group 3) p<0.001. Lesser hepatoprotection was provided by T.dioica aqueous extract 200mg/kg (ALT: 439.93, AST: 367.87, ALP: 180.62 U/L bilirubin: 1.53 mg/dl: Group VI) and least by 300mg/kg & 200mg/kg methanolic extracts Groups V & IV (ALT: 6338.06, 6443.91, AST: 2800.81, 3012.34, ALP: 242, 248 U/L & bilirubin: 2.82 & 3.62 mg/dl) respectively. Further, no drug-induced toxicity symptoms were observed 24 hours after administration of the high dose oral T. dioica 2000 mg/kg/body weight aqueous and methanolic extracts were administered. Conclusion: Pretreatment with T. dioica extracts especially 300mg/kg aqueous extract reduc
{"title":"Tamarix dioica (Ghaz) Protective Potential in the Carbon Tetrachloride-Induced Hepatotoxicity Animal Model","authors":"S. Komal, Aqna Malik, N. Akhtar, S. A. J. Kazmi, F. Anjum, A. Rida","doi":"10.47489/pszmc-806-35-3-37-43","DOIUrl":"https://doi.org/10.47489/pszmc-806-35-3-37-43","url":null,"abstract":"Introduction: Hepatic diseases remain the leading cause of death worldwide. Despite overall advancements in health care, mortality due to hepatic diseases is constantly growing. More than 2 million people globally are estimated to die each year from liver diseases, and current treatment offers little for its management. Thus, it is essential to find more effective and less toxic pharmaceutical alternatives for the treatment of liver diseases.\u0000Aims & Objectives: Tamarix dioica, a shrub broadly used in herbal medicine for the treatment and prevention of various diseases. The current study was designed to analyze the hepatoprotective effect of T. dioica in BALB?cmice against CCl4-induced acute liver damage.\u0000Place and duration of study: The study was conducted in NIH, Islamabad, Pakistan, for six months in 2016-2017. Material & Methods: For in vivo evaluation, the animals (n= 42) were randomly divided into seven groups (n=6), three control (i.e. Group, I or normal control, group II or induction control received 0.9% normal saline orally, and Group III or positive control received silymarin 100 mg/kg per oral), and four treatment groups (i.e. IV, V,VI and VII were treated\u0000with oral T.dioica 200 mg/kg/day, 300mg/kg/day methanol extract, 200mg/kg/day and 300mg/kg/day of aqueous extracts respectively for six days, followed by intraperitoneal administration of CCl4 on the seventh day. The blood samples were collected for analysis of LFTs, and hepatic tissue was taken for histological analysis. Data was analyzed using SPSS version 16, one-way ANOVA with Duncan’s Multiple Range Test (DMRT).\u0000Results: CCl4 induction in Group 2 resulted in severe hepatic derangement manifested as highly elevated mean LFTs (ALT 7245.56, AST 3292.11, ALP 340.09 U/L, bilirubin 4.64 mg/dl) as compared to healthy controls (ALT 38.97, AST 50.20, ALP 57.17 U/L, bilirubin 1.25 mg/dl: (Group 1) levels p<0.001. Pretreatment with different extracts of T.dioica for 6 days before CCl4 administration produced varying degrees of hepatoprotection. 300mg/kg aqueous extract T.dioica\u0000(Group7) prevented damage with maximal hepatoprotection, reduced LFTs (ALT: 339.95 , AST: 242.90 , ALP: 116.86 U/L, bilirubin: 1.38 mg/dl) and normalized liver histology as compared to Group 2 and standard drug silymarin 100mg/kg, (ALT: 6483.23, AST: 2567.69, ALP: 272.19 U/L, bilirubin: 2.84 mg/dl: Group 3) p<0.001. Lesser hepatoprotection was provided by T.dioica aqueous extract 200mg/kg (ALT: 439.93, AST: 367.87, ALP: 180.62 U/L bilirubin: 1.53 mg/dl: Group VI) and least by 300mg/kg & 200mg/kg methanolic extracts Groups V & IV (ALT: 6338.06, 6443.91, AST: 2800.81, 3012.34, ALP: 242, 248 U/L & bilirubin: 2.82 & 3.62 mg/dl) respectively. Further, no drug-induced toxicity symptoms were observed 24 hours after administration of the high dose oral T. dioica 2000 mg/kg/body weight aqueous and methanolic extracts were administered.\u0000Conclusion: Pretreatment with T. dioica extracts especially 300mg/kg aqueous extract reduc","PeriodicalId":20500,"journal":{"name":"Proceedings of Shaikh Zayed Medical Complex Lahore","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85091351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-15DOI: 10.47489/pszmc1987p000s351
Terrence V. Stange, L. A. Bader
{"title":"Volume 35, Issue 1","authors":"Terrence V. Stange, L. A. Bader","doi":"10.47489/pszmc1987p000s351","DOIUrl":"https://doi.org/10.47489/pszmc1987p000s351","url":null,"abstract":"","PeriodicalId":20500,"journal":{"name":"Proceedings of Shaikh Zayed Medical Complex Lahore","volume":"151 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74038535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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