Pub Date : 2026-03-17DOI: 10.1007/s12602-026-10983-2
Qi Zhang, Yang Yang, Shuqi Li, Jiachi Chiou, Qian Zhao
{"title":"Synergistic Effects of Auranofin and Lysozyme Against Staphylococcus Aureus.","authors":"Qi Zhang, Yang Yang, Shuqi Li, Jiachi Chiou, Qian Zhao","doi":"10.1007/s12602-026-10983-2","DOIUrl":"https://doi.org/10.1007/s12602-026-10983-2","url":null,"abstract":"","PeriodicalId":20506,"journal":{"name":"Probiotics and Antimicrobial Proteins","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147475109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-16DOI: 10.1007/s12602-026-10985-0
Yang Yu, Zi-Yan Liu, Tian-Sheng Zhu, Xiao-Zheng Yu
{"title":"Progress on the Mechanisms of Probiotics in Mitigating Ammonia Nitrogen Stress and Their Application in Fish.","authors":"Yang Yu, Zi-Yan Liu, Tian-Sheng Zhu, Xiao-Zheng Yu","doi":"10.1007/s12602-026-10985-0","DOIUrl":"https://doi.org/10.1007/s12602-026-10985-0","url":null,"abstract":"","PeriodicalId":20506,"journal":{"name":"Probiotics and Antimicrobial Proteins","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147469165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-14DOI: 10.1007/s12602-026-10956-5
Abbas Khan, Mona A Sawali, Anwar Mohammad, Fakhrul Hasssan, Fahad M Alshabrmi, Eid A Alatawi, Sergio Crovella, Dong-Qing Wei, Abdelali Agouni
{"title":"Bridging Generative AI and Diffusion Models With Molecular Simulation to Design Anti-Quorum-Sensing De novo Peptides Targeting LasR of Pseudomonas aeruginosa.","authors":"Abbas Khan, Mona A Sawali, Anwar Mohammad, Fakhrul Hasssan, Fahad M Alshabrmi, Eid A Alatawi, Sergio Crovella, Dong-Qing Wei, Abdelali Agouni","doi":"10.1007/s12602-026-10956-5","DOIUrl":"https://doi.org/10.1007/s12602-026-10956-5","url":null,"abstract":"","PeriodicalId":20506,"journal":{"name":"Probiotics and Antimicrobial Proteins","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147459766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-14DOI: 10.1007/s12602-026-10925-y
Seo-Joon Yeom, Jihye Yang, Ki-Nam Yoon, Sang-Su Kim, Min-Ji Cho, Jong-Heum Park, Beom-Seok Song, Joo Hyung Park, Yeung Bae Jin, Young-Min Kim, Seung-Hwan Park, Ju Huck Lee, Hyeun Bum Kim, Ju-Hoon Lee, Jae-Kyung Kim
{"title":"Safety and Next-Generation Probiotic Potential of Mitsuokella multacida AGMB01124 Newly Isolated from Healthy Swine Feces.","authors":"Seo-Joon Yeom, Jihye Yang, Ki-Nam Yoon, Sang-Su Kim, Min-Ji Cho, Jong-Heum Park, Beom-Seok Song, Joo Hyung Park, Yeung Bae Jin, Young-Min Kim, Seung-Hwan Park, Ju Huck Lee, Hyeun Bum Kim, Ju-Hoon Lee, Jae-Kyung Kim","doi":"10.1007/s12602-026-10925-y","DOIUrl":"https://doi.org/10.1007/s12602-026-10925-y","url":null,"abstract":"","PeriodicalId":20506,"journal":{"name":"Probiotics and Antimicrobial Proteins","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147459753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Advancing Fish Health: Systematic and Bibliometric Insights into Functional Feed Additives for Common Carp and Rainbow Trout.","authors":"Alireza Azizian, Laleh Roomiani, Mehdi Shamsaie Mehrgan, Seyed Pezhman Hosseini Shekarabi","doi":"10.1007/s12602-026-10946-7","DOIUrl":"https://doi.org/10.1007/s12602-026-10946-7","url":null,"abstract":"","PeriodicalId":20506,"journal":{"name":"Probiotics and Antimicrobial Proteins","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147459674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-12DOI: 10.1007/s12602-026-10975-2
Taoqiu Deng, Zhinuo Du, Huifen Liang, Dexin Jiao, Jinkun Li, Yuqing Zheng, Ming Zhang, Bin Zhang, Yongzhen Zhao, Zhixun Guo, Ngoc Tuan Tran, Shengkang Li
Butyrate-producing bacteria (BPB) are widely used as additives in aquaculture because of the beneficial effects of the butyrate they produce. However, most available BPB currently are of terrestrial origin, which are quite different from aquatic animals, resulting in profoundly unstable probiotic performance. This study isolated a novel, indigenous BPB, Clostridium moniliforme G18, from the gut of mud crabs, Scylla paramamosain. The strain demonstrated robust butyric acid production, tolerance to gastrointestinal conditions (pH 4-9, 0-3% NaCl, 0.4-1.0% bile salts), antibiotic sensitivity, pathogen inhibition, and non-hemolytic activity. Dietary supplementation with G18 alone or in combination with resistant starch and galactooligosaccharides (GR18) significantly enhanced mud crab body weight (P < 0.05). The supplementation improved intestinal health by enhancing histomorphology and upregulating tight junction genes (ZO-1 and Claudin). Furthermore, it boosted antioxidant capacity (elevated SOD and CAT; reduced MDA), modulated immune responses (increased AKP and ACP; reduced ALT and AST, P < 0.05), and increased intestinal butyrate levels. Analysis of the gut microbiota of mud crabs fed G18 alone or in combination with prebiotics revealed an increase in alpha diversity and beneficial composition changes (including reduced Vibrionaceae and elevated Proteocatella, P < 0.05). Following Vibrio parahaemolyticus challenge, mud crabs fed G18 and GR18 showed significantly higher survival rate (66.7% and 73.3%, respectively, P < 0.05) versus 53.3% in the control group. These diets mitigated intestinal damage, restored immune and antioxidant parameters, and enhanced the expression of barrier function genes. These results establish indigenous C. moniliforme G18 as a highly promising probiotic candidate for enhancing growth and health in mud crabs.
丁酸产菌（butyrate - production bacteria， BPB）因其所产丁酸盐的有益作用而被广泛用作水产养殖添加剂。然而，目前大多数可用的BPB都是陆生的，这与水生动物有很大的不同，导致益生菌性能极不稳定。本研究从泥蟹Scylla paramamosain肠道中分离出一种新的本土BPB，念珠状梭菌G18。该菌株表现出强大的丁酸生产能力，对胃肠道条件（pH 4-9, 0-3% NaCl, 0.4-1.0%胆盐）的耐受性，抗生素敏感性，病原体抑制能力和非溶血活性。饲粮中单独添加G18或与抗性淀粉和低聚半乳糖（GR18）联合添加均显著提高了泥蟹的体重(P
{"title":"A Novel Indigenous Probiotic, Clostridium moniliforme G18, Confers Health Benefits to Mud Crabs (Scylla paramamosain).","authors":"Taoqiu Deng, Zhinuo Du, Huifen Liang, Dexin Jiao, Jinkun Li, Yuqing Zheng, Ming Zhang, Bin Zhang, Yongzhen Zhao, Zhixun Guo, Ngoc Tuan Tran, Shengkang Li","doi":"10.1007/s12602-026-10975-2","DOIUrl":"https://doi.org/10.1007/s12602-026-10975-2","url":null,"abstract":"<p><p>Butyrate-producing bacteria (BPB) are widely used as additives in aquaculture because of the beneficial effects of the butyrate they produce. However, most available BPB currently are of terrestrial origin, which are quite different from aquatic animals, resulting in profoundly unstable probiotic performance. This study isolated a novel, indigenous BPB, Clostridium moniliforme G18, from the gut of mud crabs, Scylla paramamosain. The strain demonstrated robust butyric acid production, tolerance to gastrointestinal conditions (pH 4-9, 0-3% NaCl, 0.4-1.0% bile salts), antibiotic sensitivity, pathogen inhibition, and non-hemolytic activity. Dietary supplementation with G18 alone or in combination with resistant starch and galactooligosaccharides (GR18) significantly enhanced mud crab body weight (P < 0.05). The supplementation improved intestinal health by enhancing histomorphology and upregulating tight junction genes (ZO-1 and Claudin). Furthermore, it boosted antioxidant capacity (elevated SOD and CAT; reduced MDA), modulated immune responses (increased AKP and ACP; reduced ALT and AST, P < 0.05), and increased intestinal butyrate levels. Analysis of the gut microbiota of mud crabs fed G18 alone or in combination with prebiotics revealed an increase in alpha diversity and beneficial composition changes (including reduced Vibrionaceae and elevated Proteocatella, P < 0.05). Following Vibrio parahaemolyticus challenge, mud crabs fed G18 and GR18 showed significantly higher survival rate (66.7% and 73.3%, respectively, P < 0.05) versus 53.3% in the control group. These diets mitigated intestinal damage, restored immune and antioxidant parameters, and enhanced the expression of barrier function genes. These results establish indigenous C. moniliforme G18 as a highly promising probiotic candidate for enhancing growth and health in mud crabs.</p>","PeriodicalId":20506,"journal":{"name":"Probiotics and Antimicrobial Proteins","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147444827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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