Objective: To explore the feasibility of two-dimensional shear wave elastography in evaluating calf skeletal muscle stiffness in diabetic nephropathy patients with medial tibial stress syndrome. Methods: A total of 48 diabetic nephropathy patients with medial tibial stress syndrome from January 2020 to December 2022 were included as the study group, and 48 patients with diabetic nephropathy during the same period were included as the control group. Both groups were detected by two-dimensional shear wave elastography with ultrasonic equipment, and Young‘s modulus of the tibialis anterior muscle, tibialis posterior muscle, and gastrocnemius muscle were observed and analyzed in the two groups. Results: The Young‘s modulus values of tibialis anterior muscle, tibialis posterior muscle, and gastrocnemius muscle in the study group were significantly lower than those in the control group (P < 0.05). Conclusion: Two-dimensional shear wave elastography is feasible for the evaluation of calf skeletal muscle stiffness in diabetic nephropathy patients with medial tibial stress syndrome, and has high accuracy and repeatability. This technique can be used to diagnose, treat and monitor muscle lesions in patients with diabetic nephropathy, and can also be used to assess muscle fatigue and exercise capacity, which has broad application prospects.
{"title":"Assessment of Calf Skeletal Muscle Stiffness in Diabetic Nephropathy Patients with Medial Tibial Stress Syndrome by Two-Dimensional Shear Wave Elastography","authors":"Lei Wang, Lei Ran","doi":"10.26689/par.v7i5.4470","DOIUrl":"https://doi.org/10.26689/par.v7i5.4470","url":null,"abstract":"Objective: To explore the feasibility of two-dimensional shear wave elastography in evaluating calf skeletal muscle stiffness in diabetic nephropathy patients with medial tibial stress syndrome. Methods: A total of 48 diabetic nephropathy patients with medial tibial stress syndrome from January 2020 to December 2022 were included as the study group, and 48 patients with diabetic nephropathy during the same period were included as the control group. Both groups were detected by two-dimensional shear wave elastography with ultrasonic equipment, and Young‘s modulus of the tibialis anterior muscle, tibialis posterior muscle, and gastrocnemius muscle were observed and analyzed in the two groups. Results: The Young‘s modulus values of tibialis anterior muscle, tibialis posterior muscle, and gastrocnemius muscle in the study group were significantly lower than those in the control group (P < 0.05). Conclusion: Two-dimensional shear wave elastography is feasible for the evaluation of calf skeletal muscle stiffness in diabetic nephropathy patients with medial tibial stress syndrome, and has high accuracy and repeatability. This technique can be used to diagnose, treat and monitor muscle lesions in patients with diabetic nephropathy, and can also be used to assess muscle fatigue and exercise capacity, which has broad application prospects.","PeriodicalId":20511,"journal":{"name":"Proceedings of Anticancer Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135864750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To evaluate the efficacy of emergency ventilator therapy in severe acute left heart failure. Methods: A total of 75 patients with severe acute left ventricular heart failure who were admitted to the hospital from July 2020 to July 2023 were randomly divided into two groups. Group A received additional emergency ventilator treatment, and group B received conventional treatment. The efficacy was compared. Results: The curative effect of patients with severe acute left heart failure in group A was higher than that in group B (P < 0.05); all blood gas indicators in group A were better than those in group B (P < 0.05); all vital signs indicators in group A were better than those in group B (P < 0.05); group A was more satisfied with the treatment of severe acute left ventricular heart failure than group B (P < 0.05). Conclusion: Patients with severe acute left heart failure who receive emergency ventilator treatment can stabilize vital signs, improve blood oxygen supply, and enhance curative effect.
{"title":"Evaluating the Effectiveness of Emergency Ventilator Treatment for Severe Acute Left Ventricular Heart Failure","authors":"Hua Zhou","doi":"10.26689/par.v7i5.5401","DOIUrl":"https://doi.org/10.26689/par.v7i5.5401","url":null,"abstract":"Objective: To evaluate the efficacy of emergency ventilator therapy in severe acute left heart failure. Methods: A total of 75 patients with severe acute left ventricular heart failure who were admitted to the hospital from July 2020 to July 2023 were randomly divided into two groups. Group A received additional emergency ventilator treatment, and group B received conventional treatment. The efficacy was compared. Results: The curative effect of patients with severe acute left heart failure in group A was higher than that in group B (P < 0.05); all blood gas indicators in group A were better than those in group B (P < 0.05); all vital signs indicators in group A were better than those in group B (P < 0.05); group A was more satisfied with the treatment of severe acute left ventricular heart failure than group B (P < 0.05). Conclusion: Patients with severe acute left heart failure who receive emergency ventilator treatment can stabilize vital signs, improve blood oxygen supply, and enhance curative effect.","PeriodicalId":20511,"journal":{"name":"Proceedings of Anticancer Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135865895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To observe the clinical effect of emergency interventional therapy for patients with acute severe non-variceal upper gastrointestinal bleeding. Methods: 78 patients with acute severe non-variceal upper gastrointestinal bleeding who were treated in the General Hospital of the Eastern Theater Command from May 2020 to May 2023 were randomly divided into two groups according to different treatment plans. The study group underwent emergency upper gastrointestinal angiography and interventional embolization therapy, the control group was treated with esomeprazole; the clinical data related to the two groups were compared, including the total effective rate of treatment, blood pressure stabilization time, bleeding control time, etc. Results: The effective rate of clinical treatment in the study group was 97.44%, which was higher than that in the control group, which was 79.49% (P < 0.05). Both were significantly shorter (P < 0.05); the 7 d rebleeding rate and 30 d rebleeding rate of the study group were lower than those of the control group (P < 0.05); the 7 d and 30 d mortality rates of the two groups after treatment were compared, and the comparative study group was lower, but there was no significant difference (P > 0.05). Conclusion: Emergency interventional therapy can control bleeding more quickly, shorten bleeding control time and complete hemostasis time, shorten blood pressure stabilization time and abdominal pain relief time, and reduce rebleeding rate in patients with acute severe non-variceal upper gastrointestinal bleeding.
{"title":"Observation on the Clinical Effect of Emergency Interventional Therapy on Acute Severe Non- Variceal Upper Gastrointestinal Bleeding","authors":"Bo Chen, Donghong Shi, Min Ai, Longjiang Zhang","doi":"10.26689/par.v7i5.5301","DOIUrl":"https://doi.org/10.26689/par.v7i5.5301","url":null,"abstract":"Objective: To observe the clinical effect of emergency interventional therapy for patients with acute severe non-variceal upper gastrointestinal bleeding. Methods: 78 patients with acute severe non-variceal upper gastrointestinal bleeding who were treated in the General Hospital of the Eastern Theater Command from May 2020 to May 2023 were randomly divided into two groups according to different treatment plans. The study group underwent emergency upper gastrointestinal angiography and interventional embolization therapy, the control group was treated with esomeprazole; the clinical data related to the two groups were compared, including the total effective rate of treatment, blood pressure stabilization time, bleeding control time, etc. Results: The effective rate of clinical treatment in the study group was 97.44%, which was higher than that in the control group, which was 79.49% (P < 0.05). Both were significantly shorter (P < 0.05); the 7 d rebleeding rate and 30 d rebleeding rate of the study group were lower than those of the control group (P < 0.05); the 7 d and 30 d mortality rates of the two groups after treatment were compared, and the comparative study group was lower, but there was no significant difference (P > 0.05). Conclusion: Emergency interventional therapy can control bleeding more quickly, shorten bleeding control time and complete hemostasis time, shorten blood pressure stabilization time and abdominal pain relief time, and reduce rebleeding rate in patients with acute severe non-variceal upper gastrointestinal bleeding.","PeriodicalId":20511,"journal":{"name":"Proceedings of Anticancer Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135864306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This report describes a considerably rare case of high-grade urothelial carcinoma of the renal pelvis and ureter, presenting with heterologous differentiation, in a patient with bilateral duplicated kidneys. A 73-year-old male experienced intermittent gross hematuria for 5 months, accompanied by lower back and abdominal pain. Ultrasound and computed tomography scans revealed bilateral renal and ureteral duplication with multiple tumors in the left renal pelvis. A total nephroterectomy and bladder cuff resection were performed on the left two nephrons. Multiple space-occupying lesions were identified in the left renal pelvis and ureter. Histopathological examination showed poorly differentiated and diverse tumor cells, manifesting as sarcomatoid carcinoma, papillary adenocarcinoma, and infiltrating high-grade urothelial carcinoma. The tumor infiltrated the subcutaneous fibrous connective tissue of the renal pelvis and the full thickness of the ureter. Given the rarity of recurrent renal urothelial carcinoma with heterogeneous differentiation, comprehensive imaging and pathological assessments are vital to delineate the nature of the lesion and the direction of tissue pathological heterologous differentiation. These evaluations guide early radical surgical interventions, improving survival rates.
{"title":"A Case Report: High-Grade Urothelial Carcinoma in the Renal Pelvis with Complete Kidney and Ureter Duplication Featuring Heterologous Differentiation","authors":"Pan Wang, Lina Li, Pei Zhang, Yanan Wang","doi":"10.26689/par.v7i5.5411","DOIUrl":"https://doi.org/10.26689/par.v7i5.5411","url":null,"abstract":"This report describes a considerably rare case of high-grade urothelial carcinoma of the renal pelvis and ureter, presenting with heterologous differentiation, in a patient with bilateral duplicated kidneys. A 73-year-old male experienced intermittent gross hematuria for 5 months, accompanied by lower back and abdominal pain. Ultrasound and computed tomography scans revealed bilateral renal and ureteral duplication with multiple tumors in the left renal pelvis. A total nephroterectomy and bladder cuff resection were performed on the left two nephrons. Multiple space-occupying lesions were identified in the left renal pelvis and ureter. Histopathological examination showed poorly differentiated and diverse tumor cells, manifesting as sarcomatoid carcinoma, papillary adenocarcinoma, and infiltrating high-grade urothelial carcinoma. The tumor infiltrated the subcutaneous fibrous connective tissue of the renal pelvis and the full thickness of the ureter. Given the rarity of recurrent renal urothelial carcinoma with heterogeneous differentiation, comprehensive imaging and pathological assessments are vital to delineate the nature of the lesion and the direction of tissue pathological heterologous differentiation. These evaluations guide early radical surgical interventions, improving survival rates.","PeriodicalId":20511,"journal":{"name":"Proceedings of Anticancer Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135864309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To analyze the application of deep inspiration breath hold technique in radiotherapy after breast-conserving surgery for left breast cancer and the improvement of cardiac dose. Methods: A total of 45 patients with left breast cancer treated in our hospital after breast-conserving surgery were selected, and the selection time was set from January 2020 to August 2022. All patients received radiotherapy. The right breast, heart, and lung volumes, and dose parameters of the heart, lungs, right breast, and left anterior descending coronary artery were compared under free breathing (FB) and deep inspiration breath hold (DIBH) technical modes. Results: The heart volume of the DIBH group was smaller than that of the FB group, and the left and right lung volumes were significantly larger than those of the FB group. In the DIBH group, the heart dose parameters V5, proper lung dose parameters, and left anterior descending coronary artery dose parameters were found lower than that of the FB group, and the differences were statistically significant (P < 0.05). Conclusion: Compared with FB, the DIBH technique can reduce the heart’s size and increase the lung volume when used for radiotherapy after breast-conserving surgery for left breast cancer. It also reduces the dose to the heart, right lung, and left anterior descending coronary artery, thus protecting the heart and lungs.
{"title":"Application of Deep Inspiration Breath Hold Technique in Radiotherapy After Breast- Conserving Surgery for Left Breast Cancer and Its Improvement on Cardiac Dose","authors":"Yu Luo, Lihan Huang, Qiao Lan, Yurui Wu, Yin Li, Xiaorong Cheng, Kunhai Xiong, Xiaoyu Wu","doi":"10.26689/par.v7i5.5373","DOIUrl":"https://doi.org/10.26689/par.v7i5.5373","url":null,"abstract":"Objective: To analyze the application of deep inspiration breath hold technique in radiotherapy after breast-conserving surgery for left breast cancer and the improvement of cardiac dose. Methods: A total of 45 patients with left breast cancer treated in our hospital after breast-conserving surgery were selected, and the selection time was set from January 2020 to August 2022. All patients received radiotherapy. The right breast, heart, and lung volumes, and dose parameters of the heart, lungs, right breast, and left anterior descending coronary artery were compared under free breathing (FB) and deep inspiration breath hold (DIBH) technical modes. Results: The heart volume of the DIBH group was smaller than that of the FB group, and the left and right lung volumes were significantly larger than those of the FB group. In the DIBH group, the heart dose parameters V5, proper lung dose parameters, and left anterior descending coronary artery dose parameters were found lower than that of the FB group, and the differences were statistically significant (P < 0.05). Conclusion: Compared with FB, the DIBH technique can reduce the heart’s size and increase the lung volume when used for radiotherapy after breast-conserving surgery for left breast cancer. It also reduces the dose to the heart, right lung, and left anterior descending coronary artery, thus protecting the heart and lungs.","PeriodicalId":20511,"journal":{"name":"Proceedings of Anticancer Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135865897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To explore the effect of continuous non-invasive blood pressure monitoring on intraoperative hemodynamics and postoperative myocardial injury in craniotomy. Methods: 120 cases of elective craniotomy were divided into the self-control group (continuous non-invasive blood pressure monitoring and intermittent cuff non-invasive blood pressure monitoring, CNAP group) and propensity score matching group (only intermittent cuff non-invasive blood pressure measurement in previous craniotomy, PSM group); Goal-directed hemodynamic management in CNAP group included heart rate (HR), blood pressure (BP), stroke volume (SV), stroke variability (SVV), and systemic vascular resistance index (SVRI). The main index is to compare the troponin level within 72 hours after operation between the CNAP group and the PSM group; The secondary indicators are the comparison of the hemodynamic conditions between the CNAP group and the PSM at 10 specific time points. Results: The incidence of postoperative myocardial injury in the CNAP group was significantly lower than that in the PSM group (12% vs. 30%, P = 0.01); in the CNAP group hypotensive episodes (6 vs. 3, P = 0.01), positive balance of fluid therapy (700 vs. 500 mL, P < 0.001), more use of vasoactive drugs (29 vs. 18, P = 0.04), more stable hemodynamics medical status (P = 0.03) were recorded. Conclusion: The hemodynamic management strategy based on continuous non-invasive blood pressure monitoring can reduce the incidence of myocardial injury after elective craniotomy and maintain a more stable hemodynamic state.
目的:探讨连续无创血压监测对开颅术中血流动力学及术后心肌损伤的影响。方法:将120例择期开颅患者分为自我控制组(连续无创血压监测和间歇袖带无创血压监测，CNAP组)和倾向评分匹配组(既往开颅仅间歇袖带无创血压测量，PSM组);CNAP组目标导向血流动力学管理包括心率(HR)、血压(BP)、脑卒中容量(SV)、脑卒中变异性(SVV)和全身血管阻力指数(SVRI)。主要指标是比较CNAP组与PSM组术后72小时内肌钙蛋白水平;次要指标为CNAP组与PSM组在10个特定时间点的血流动力学情况比较。结果:CNAP组术后心肌损伤发生率显著低于PSM组(12% vs. 30%， P = 0.01);CNAP组低血压发作(6次vs 3次，P = 0.01)，液体治疗正平衡(700 mL vs 500 mL, P <0.001)，使用血管活性药物较多(29 vs. 18, P = 0.04)，血流动力学医疗状况较稳定(P = 0.03)。结论:基于连续无创血压监测的血流动力学管理策略可降低择期开颅术后心肌损伤的发生率，维持更稳定的血流动力学状态。
{"title":"Effects of Continuous Non-Invasive Blood Pressure Monitoring on Intraoperative Hemodynamics and Postoperative Myocardial Injury in Craniotomy: Comparison Between Groups Based on Self-Control and Propensity Score Matching","authors":"Yi Tang, Bingchun Xia, Cibo Chen, Chunyan Zhao","doi":"10.26689/par.v7i5.5321","DOIUrl":"https://doi.org/10.26689/par.v7i5.5321","url":null,"abstract":"Objective: To explore the effect of continuous non-invasive blood pressure monitoring on intraoperative hemodynamics and postoperative myocardial injury in craniotomy. Methods: 120 cases of elective craniotomy were divided into the self-control group (continuous non-invasive blood pressure monitoring and intermittent cuff non-invasive blood pressure monitoring, CNAP group) and propensity score matching group (only intermittent cuff non-invasive blood pressure measurement in previous craniotomy, PSM group); Goal-directed hemodynamic management in CNAP group included heart rate (HR), blood pressure (BP), stroke volume (SV), stroke variability (SVV), and systemic vascular resistance index (SVRI). The main index is to compare the troponin level within 72 hours after operation between the CNAP group and the PSM group; The secondary indicators are the comparison of the hemodynamic conditions between the CNAP group and the PSM at 10 specific time points. Results: The incidence of postoperative myocardial injury in the CNAP group was significantly lower than that in the PSM group (12% vs. 30%, P = 0.01); in the CNAP group hypotensive episodes (6 vs. 3, P = 0.01), positive balance of fluid therapy (700 vs. 500 mL, P < 0.001), more use of vasoactive drugs (29 vs. 18, P = 0.04), more stable hemodynamics medical status (P = 0.03) were recorded. Conclusion: The hemodynamic management strategy based on continuous non-invasive blood pressure monitoring can reduce the incidence of myocardial injury after elective craniotomy and maintain a more stable hemodynamic state.","PeriodicalId":20511,"journal":{"name":"Proceedings of Anticancer Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135865899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To study the therapeutic efficacy of patients with ulcerative colitis receiving Bifidobacterium quadruple viable tablets. Methods: 49 cases were selected from ulcerative colitis patients who attended the clinic from February 2021 to November 2022, and were randomly grouped into group A for addition of Bifidobacterium quadruple viable tablets treatment, and group B for conventional medication. The efficacy, inflammatory factors, nutritional indexes, and adverse reactions were compared between the groups. Results: The efficacy of UC patients in group A was higher than that in group B (P < 0.05); the inflammatory factors in group A were lower than that in group B (P < 0.05); nutritional indicators in group A were higher than that in group B (P < 0.05); and the adverse reactions of medication in UC patients in group A were lower than that in group B (P < 0.05). Conclusion: The treatment of UC patients with the addition of Bifidobacterium quadruple viable tablets can improve the nutritional status of the organism, inhibit the progression of inflammation, and is safe and efficient in treating ulcerative colitis.
{"title":"Study on the Effect of Bifidobacterium Quadruple Viable Tablets in the Treatment of Ulcerative Colitis","authors":"Mengyuan Wang","doi":"10.26689/par.v7i5.5403","DOIUrl":"https://doi.org/10.26689/par.v7i5.5403","url":null,"abstract":"Objective: To study the therapeutic efficacy of patients with ulcerative colitis receiving Bifidobacterium quadruple viable tablets. Methods: 49 cases were selected from ulcerative colitis patients who attended the clinic from February 2021 to November 2022, and were randomly grouped into group A for addition of Bifidobacterium quadruple viable tablets treatment, and group B for conventional medication. The efficacy, inflammatory factors, nutritional indexes, and adverse reactions were compared between the groups. Results: The efficacy of UC patients in group A was higher than that in group B (P < 0.05); the inflammatory factors in group A were lower than that in group B (P < 0.05); nutritional indicators in group A were higher than that in group B (P < 0.05); and the adverse reactions of medication in UC patients in group A were lower than that in group B (P < 0.05). Conclusion: The treatment of UC patients with the addition of Bifidobacterium quadruple viable tablets can improve the nutritional status of the organism, inhibit the progression of inflammation, and is safe and efficient in treating ulcerative colitis.","PeriodicalId":20511,"journal":{"name":"Proceedings of Anticancer Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135866046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jirui Sun, Qiushuang Ma, Hong Chen, Xing Zhou, Jinku Zhang
Objective: To explore the detection and clinical significance of peripheral blood CTC, CA125, CA153, and CEA levels in patients with DCIS. Methods: 210 patients who received surgical treatment for breast cancer in our hospital from January 2019 to December 2022 were selected as the research subjects. According to the postoperative pathology, 100 cases were divided into breast cancer and 110 benign breast tumor groups. One hundred ten healthy patients undergoing physical examination during the same period were selected as the control group. CA153, CA125, and CEA levels were observed in the three groups. Results: The levels of CA153, CA125, and CEA in the breast cancer group were significantly higher than those in the benign breast tumor group and the control group (P < 0.05); the levels of CA153, CA125, and CEA in the benign breast tumor group were all higher than those in the control group, but the differences were not statistically significant; among the three tumor markers, CA153 has the highest sensitivity at 39.00%, CA125 has the second highest sensitivity at 18.00%, and CEA has the lowest sensitivity at 17.00%; The sensitivity of the two joint tests of CA153+CA125, CA153+CEA, and CA125+CEA for the diagnosis of breast cancer were 50.00%, 48.00%, and 26.00% respectively; the sensitivity of the three joint tests is the highest, reaching 53.00%, while the specificity of the joint tests was lower than the individual tests. Conclusion: Detection of peripheral blood CTC, CA125, CA153, and CEA levels has specific reference significance for the treatment and prognosis of DCIS patients.
{"title":"Detection and Clinical Significance of Peripheral Blood CTC, CA125, CA153, and CEA Levels in Patients with Ductal Carcinoma in situ","authors":"Jirui Sun, Qiushuang Ma, Hong Chen, Xing Zhou, Jinku Zhang","doi":"10.26689/par.v7i5.5418","DOIUrl":"https://doi.org/10.26689/par.v7i5.5418","url":null,"abstract":"Objective: To explore the detection and clinical significance of peripheral blood CTC, CA125, CA153, and CEA levels in patients with DCIS. Methods: 210 patients who received surgical treatment for breast cancer in our hospital from January 2019 to December 2022 were selected as the research subjects. According to the postoperative pathology, 100 cases were divided into breast cancer and 110 benign breast tumor groups. One hundred ten healthy patients undergoing physical examination during the same period were selected as the control group. CA153, CA125, and CEA levels were observed in the three groups. Results: The levels of CA153, CA125, and CEA in the breast cancer group were significantly higher than those in the benign breast tumor group and the control group (P < 0.05); the levels of CA153, CA125, and CEA in the benign breast tumor group were all higher than those in the control group, but the differences were not statistically significant; among the three tumor markers, CA153 has the highest sensitivity at 39.00%, CA125 has the second highest sensitivity at 18.00%, and CEA has the lowest sensitivity at 17.00%; The sensitivity of the two joint tests of CA153+CA125, CA153+CEA, and CA125+CEA for the diagnosis of breast cancer were 50.00%, 48.00%, and 26.00% respectively; the sensitivity of the three joint tests is the highest, reaching 53.00%, while the specificity of the joint tests was lower than the individual tests. Conclusion: Detection of peripheral blood CTC, CA125, CA153, and CEA levels has specific reference significance for the treatment and prognosis of DCIS patients.","PeriodicalId":20511,"journal":{"name":"Proceedings of Anticancer Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135864452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To investigate the therapeutic effect of omeprazole + amoxicillin in patients with gastric ulcers. Methods: 62 cases of patients with gastric ulcers who were treated from January 2022 to December 2022 were recruited and randomly divided into groups. Omeprazole + amoxicillin treatment was included in the study group, and amoxicillin treatment was included in the control group. The score of gastric ulcer symptoms, time of symptom resolution, gastrointestinal hormone index, and adverse reactions were compared. Results: The gastric ulcer symptom scores in the study group were lower than those in the control group (P < 0.05); the gastric ulcer symptoms and Helicobacter pylori-negative time in the study group were shorter than those in the control group (P < 0.05); the gastrointestinal hormone indexes in the study group were better than those in the control group (P < 0.05); the adverse reaction rate of gastric ulcer in the study group was lower than that in the control group (P < 0.05). Conclusion: Omeprazole + amoxicillin in the treatment of gastric ulcers can regulate gastrointestinal hormones, relieve gastric ulcer symptoms, and shorten the duration of ulcers, which is highly effective and feasible.
{"title":"Clinical Effect of Omeprazole Combined with Amoxicillin in the Treatment of Gastric Ulcer","authors":"Yifei Liu","doi":"10.26689/par.v7i5.5300","DOIUrl":"https://doi.org/10.26689/par.v7i5.5300","url":null,"abstract":"Objective: To investigate the therapeutic effect of omeprazole + amoxicillin in patients with gastric ulcers. Methods: 62 cases of patients with gastric ulcers who were treated from January 2022 to December 2022 were recruited and randomly divided into groups. Omeprazole + amoxicillin treatment was included in the study group, and amoxicillin treatment was included in the control group. The score of gastric ulcer symptoms, time of symptom resolution, gastrointestinal hormone index, and adverse reactions were compared. Results: The gastric ulcer symptom scores in the study group were lower than those in the control group (P < 0.05); the gastric ulcer symptoms and Helicobacter pylori-negative time in the study group were shorter than those in the control group (P < 0.05); the gastrointestinal hormone indexes in the study group were better than those in the control group (P < 0.05); the adverse reaction rate of gastric ulcer in the study group was lower than that in the control group (P < 0.05). Conclusion: Omeprazole + amoxicillin in the treatment of gastric ulcers can regulate gastrointestinal hormones, relieve gastric ulcer symptoms, and shorten the duration of ulcers, which is highly effective and feasible.","PeriodicalId":20511,"journal":{"name":"Proceedings of Anticancer Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136238932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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