Objective: To investigate the safety hazards in nursing and explore mitigation strategies for elderly patients in the endocrinology department. Methods: A total of 240 bedridden elderly patients from February 2021 to January 2023 were recruited and divided into two groups using the random number table method. The control group (n = 120) received conventional nursing care, and the observation group (n = 120) received personalized nursing care. Patients’ quality of life, the incidence rate of pressure sores, and patient satisfaction with nursing care were observed and analyzed. Results: The incidence of pressure ulcers in the observation group was significantly lower at 17.50% compared to 30.00% in the control group (P < 0.05). Quality of life in the observation group was significantly higher than that in the control group (P < 0.05). The satisfaction rate in the observation group was significantly higher at 93.33% compared to 84.17% in the control group (P < 0.05). Conclusion: These findings emphasize that only through the implementation of scientific and rational nursing measures can effectively reduce nursing risks, enhance therapeutic outcomes, and improve the quality of life for elderly patients.
{"title":"Addressing Nursing Safety Hazards and Mitigation Strategies for Elderly Endocrinology Patients in Hospital Care","authors":"Yamin Zhao, Fang Zhao, Yujie Gu","doi":"10.26689/par.v7i6.5507","DOIUrl":"https://doi.org/10.26689/par.v7i6.5507","url":null,"abstract":"Objective: To investigate the safety hazards in nursing and explore mitigation strategies for elderly patients in the endocrinology department. Methods: A total of 240 bedridden elderly patients from February 2021 to January 2023 were recruited and divided into two groups using the random number table method. The control group (n = 120) received conventional nursing care, and the observation group (n = 120) received personalized nursing care. Patients’ quality of life, the incidence rate of pressure sores, and patient satisfaction with nursing care were observed and analyzed. Results: The incidence of pressure ulcers in the observation group was significantly lower at 17.50% compared to 30.00% in the control group (P < 0.05). Quality of life in the observation group was significantly higher than that in the control group (P < 0.05). The satisfaction rate in the observation group was significantly higher at 93.33% compared to 84.17% in the control group (P < 0.05). Conclusion: These findings emphasize that only through the implementation of scientific and rational nursing measures can effectively reduce nursing risks, enhance therapeutic outcomes, and improve the quality of life for elderly patients.","PeriodicalId":20511,"journal":{"name":"Proceedings of Anticancer Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138614214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To comprehend the clinical characteristics and treatment approaches for children and adolescents in Qinghai Province with two types of echinococcosis, cystic echinococcosis (CE) and alveolar echinococcosis (AE). Methods: A total of 128 pediatric inpatients with echinococcosis at the People’s Hospital of Qinghai Province and the Clinical Research Institute of Echinococcosis of Qinghai Province between January 2016 and December 2021 were chosen as subjects. Demographic and clinical data were collected, and double data entry was executed using EpiData 3.02. Factors influencing the cure of echinococcosis were analyzed with echinococcosis cure as the dependent variable, employing statistical analysis via SPSS 19.0. Results: Of the cases, 35.9% had CE, and 64.1% had AE. Both types were observed in patients of all ages, with the majority aged 13–18. The number of cysts and their sizes varied between CE and AE. Complications were prevalent, including liver, gallbladder, lung, and nutritional complications. Univariate analyses revealed significant differences in outcomes based on factors such as cyst size (for CE), liver function grade (for AE), hydatid hypersensitivity test, operation, and length of hospital stay (P < 0.05). Conclusion: This comprehensive analysis of hospitalized cases sheds light on the clinical data of echinococcosis in children and adolescents in Qinghai Province. The findings contribute to a scientific foundation for formulating effective prevention and control measures tailored to this demographic, facilitating an improved understanding of echinococcosis in Qinghai province.
{"title":"Clinical Analysis of 128 Children and Adolescents with Echinococcosis","authors":"Linghong Zhu, Yanqing Ma, Yongmei Lan, Zilong Zhang","doi":"10.26689/par.v8i1.5734","DOIUrl":"https://doi.org/10.26689/par.v8i1.5734","url":null,"abstract":"Objective: To comprehend the clinical characteristics and treatment approaches for children and adolescents in Qinghai Province with two types of echinococcosis, cystic echinococcosis (CE) and alveolar echinococcosis (AE). Methods: A total of 128 pediatric inpatients with echinococcosis at the People’s Hospital of Qinghai Province and the Clinical Research Institute of Echinococcosis of Qinghai Province between January 2016 and December 2021 were chosen as subjects. Demographic and clinical data were collected, and double data entry was executed using EpiData 3.02. Factors influencing the cure of echinococcosis were analyzed with echinococcosis cure as the dependent variable, employing statistical analysis via SPSS 19.0. Results: Of the cases, 35.9% had CE, and 64.1% had AE. Both types were observed in patients of all ages, with the majority aged 13–18. The number of cysts and their sizes varied between CE and AE. Complications were prevalent, including liver, gallbladder, lung, and nutritional complications. Univariate analyses revealed significant differences in outcomes based on factors such as cyst size (for CE), liver function grade (for AE), hydatid hypersensitivity test, operation, and length of hospital stay (P < 0.05). Conclusion: This comprehensive analysis of hospitalized cases sheds light on the clinical data of echinococcosis in children and adolescents in Qinghai Province. The findings contribute to a scientific foundation for formulating effective prevention and control measures tailored to this demographic, facilitating an improved understanding of echinococcosis in Qinghai province.","PeriodicalId":20511,"journal":{"name":"Proceedings of Anticancer Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139210366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To investigate the impact of combining liraglutide with metformin on the enhancement of pancreatic islet function in patients with type 2 diabetes and coronary heart disease. Methods: 60 patients with type 2 diabetes and coronary heart disease admitted from February 2022 to August 2023 were selected as research subjects. They were randomly assigned to either control or treatment groups, with 30 patients in each. The control group received metformin alone, while the treatment group received liraglutide in combination with metformin. Various indicators, including blood sugar levels, pancreatic islet function, and cardiac function between the two groups were compared. Results: The results of FPG, 2hPG, HbA1c, HOMA-IR, NT-proBNP, and LVEDD in the treatment group were lower than those in the control group, whereas the values of FINS, HOMA-β, E/A, and LVEF in the treatment group were higher than those in the control group (P < 0.05). Conclusion: The use of liraglutide in combination with metformin significantly benefits patients with type 2 diabetes and coronary heart disease. It leads to improved pancreatic islet function, better blood sugar control, and enhanced cardiac function. This combination therapy is recommended for clinical adoption.
{"title":"A Study on Enhancing Pancreatic Islet Function in Type 2 Diabetes and Coronary Heart Disease Patients with Liraglutide and Metformin Combination Therapy","authors":"Chunxiao Yang","doi":"10.26689/par.v7i6.5566","DOIUrl":"https://doi.org/10.26689/par.v7i6.5566","url":null,"abstract":"Objective: To investigate the impact of combining liraglutide with metformin on the enhancement of pancreatic islet function in patients with type 2 diabetes and coronary heart disease. Methods: 60 patients with type 2 diabetes and coronary heart disease admitted from February 2022 to August 2023 were selected as research subjects. They were randomly assigned to either control or treatment groups, with 30 patients in each. The control group received metformin alone, while the treatment group received liraglutide in combination with metformin. Various indicators, including blood sugar levels, pancreatic islet function, and cardiac function between the two groups were compared. Results: The results of FPG, 2hPG, HbA1c, HOMA-IR, NT-proBNP, and LVEDD in the treatment group were lower than those in the control group, whereas the values of FINS, HOMA-β, E/A, and LVEF in the treatment group were higher than those in the control group (P < 0.05). Conclusion: The use of liraglutide in combination with metformin significantly benefits patients with type 2 diabetes and coronary heart disease. It leads to improved pancreatic islet function, better blood sugar control, and enhanced cardiac function. This combination therapy is recommended for clinical adoption.","PeriodicalId":20511,"journal":{"name":"Proceedings of Anticancer Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139247423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To explore and analyze the evaluation and driving factors of postoperative psychological pain inpatients with oral and maxillofacial malignant tumors. Methods: Relevant data were collected from 80 patients with oral and maxillofacial malignant tumors who attended the outpatient clinic for follow-up consultations between May 2021 to May 2023. The patients used the psychological distress thermometer (DT) to circle words that best described their experiences in the past week, assigning a numerical value (0–10) to indicate their pain level on each day. The scoring results were employed to assess the psychological pain in these patients. A self-developed patient basic information questionnaire was utilized to record demographic details. Logistic regression analysis was employed to evaluate patients two weeks after surgery, focusing on the assessment of psychological distress and the identification and location of driving factors. Results: Following evaluation, the results revealed that the average postoperative DT score for the 80 patients with oral and maxillofacial malignant tumors was 4.53 ± 1.98 points. Scores < 4 points indicated no psychological pain (Group N) in 48 cases, while scores ≥ 4 points indicated psychological pain (Group Y) in 32 cases. The differences in postoperative DT scores among patients with varying educational levels, fears and worries about disease progression, economic problems, sleep problems, level of hope, and oral pain were statistically significant (P < 0.05). Multiple linear regression analysis results indicated that education level, fear and worry about disease progression, economic problems, sleep problems, level of hope, and oral pain are driving factors of postoperative psychological pain in patients with oral and maxillofacial malignant tumors (P < 0.05). Conclusion: The postoperative psychological pain level in patients with oral and maxillofacial malignant tumors is at a moderate level. Educational level, fear and worry about disease progression, economic problems, sleep problems, level of hope, and oral pain were identified as driving factors for postoperative psychological pain in these patients.
{"title":"Evaluation of Postoperative Psychological Distress and Its Driving Factors in Patients with Oral and Maxillofacial Malignant Tumors","authors":"Yanqing Feng, Fengqiao Lin, Mengjun Huang","doi":"10.26689/par.v7i6.5669","DOIUrl":"https://doi.org/10.26689/par.v7i6.5669","url":null,"abstract":"Objective: To explore and analyze the evaluation and driving factors of postoperative psychological pain inpatients with oral and maxillofacial malignant tumors. Methods: Relevant data were collected from 80 patients with oral and maxillofacial malignant tumors who attended the outpatient clinic for follow-up consultations between May 2021 to May 2023. The patients used the psychological distress thermometer (DT) to circle words that best described their experiences in the past week, assigning a numerical value (0–10) to indicate their pain level on each day. The scoring results were employed to assess the psychological pain in these patients. A self-developed patient basic information questionnaire was utilized to record demographic details. Logistic regression analysis was employed to evaluate patients two weeks after surgery, focusing on the assessment of psychological distress and the identification and location of driving factors. Results: Following evaluation, the results revealed that the average postoperative DT score for the 80 patients with oral and maxillofacial malignant tumors was 4.53 ± 1.98 points. Scores < 4 points indicated no psychological pain (Group N) in 48 cases, while scores ≥ 4 points indicated psychological pain (Group Y) in 32 cases. The differences in postoperative DT scores among patients with varying educational levels, fears and worries about disease progression, economic problems, sleep problems, level of hope, and oral pain were statistically significant (P < 0.05). Multiple linear regression analysis results indicated that education level, fear and worry about disease progression, economic problems, sleep problems, level of hope, and oral pain are driving factors of postoperative psychological pain in patients with oral and maxillofacial malignant tumors (P < 0.05). Conclusion: The postoperative psychological pain level in patients with oral and maxillofacial malignant tumors is at a moderate level. Educational level, fear and worry about disease progression, economic problems, sleep problems, level of hope, and oral pain were identified as driving factors for postoperative psychological pain in these patients.","PeriodicalId":20511,"journal":{"name":"Proceedings of Anticancer Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139247789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To investigate the impact of partial gastrectomy on gastrointestinal function in the treatment of patients with early gastric cancer. Methods: A sample of 20 patients with early-stage gastric cancer treated from January 2022 to January 2023 was randomly divided into two groups. Group A underwent partial gastrectomy, while Group B underwent distal subtotal gastrectomy. Surgical outcomes, complication rates, BMI indices, and quality of life were compared. Result: All surgical outcomes of patients with early gastric cancer in group A were better than those in group B (P < 0.05); the postoperative complication rate for early gastric cancer in group A was lower than that in group B (P < 0.05); the BMI index for patients with early gastric cancer in group A was higher than that in group B at different times (P < 0.05); the postoperative quality of life (SF-36) score of group A for early gastric cancer was higher than that of group B (P < 0.05). Conclusion: Partial gastrectomy for patients with early gastric cancer can increase BMI, optimize surgical outcomes, improve gastric function, and enhance the quality of life for gastric cancer patients.
{"title":"The Effect of Partial Gastrectomy in the Treatment of Early Gastric Cancer and Its Impact on the Gastrointestinal Function of Patients","authors":"Bo Zhao, Chonglin Liu","doi":"10.26689/par.v7i6.5514","DOIUrl":"https://doi.org/10.26689/par.v7i6.5514","url":null,"abstract":"Objective: To investigate the impact of partial gastrectomy on gastrointestinal function in the treatment of patients with early gastric cancer. Methods: A sample of 20 patients with early-stage gastric cancer treated from January 2022 to January 2023 was randomly divided into two groups. Group A underwent partial gastrectomy, while Group B underwent distal subtotal gastrectomy. Surgical outcomes, complication rates, BMI indices, and quality of life were compared. Result: All surgical outcomes of patients with early gastric cancer in group A were better than those in group B (P < 0.05); the postoperative complication rate for early gastric cancer in group A was lower than that in group B (P < 0.05); the BMI index for patients with early gastric cancer in group A was higher than that in group B at different times (P < 0.05); the postoperative quality of life (SF-36) score of group A for early gastric cancer was higher than that of group B (P < 0.05). Conclusion: Partial gastrectomy for patients with early gastric cancer can increase BMI, optimize surgical outcomes, improve gastric function, and enhance the quality of life for gastric cancer patients.","PeriodicalId":20511,"journal":{"name":"Proceedings of Anticancer Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139248986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To investigate the detection of Th17/Treg cell-related factors in patients with gestational diabetes mellitus (GDM) and its clinical significance. Methods: In this study, a retrospective cohort research method was used to collect the clinical data of 42 patients who were hospitalized in the Affiliated Hospital of Hebei University and received the diagnosis of GDM from January 2018 to December 2022, as well as 42 patients with normal pregnancies during the same period. The Th17/Treg expression levels and metabolism-related indexes in the peripheral blood of patients were detected by radioimmunoassay. Results: The relative expression of Th17 in the serum of patients in the GDM group was significantly higher than that of the control group, and the level of Treg was significantly lower than that of the control group (P < 0.05); the levels of FBG, FINS, 2hBG, TC, TG and HOMA-IR of the patients in the GDM group were significantly higher than that of the control group, and the level of HOMA-β was significantly lower than that of the control group (P < 0.05). Conclusion: The imbalance of the Th17/Treg cell ratio in patients with GDM may be related to their disease progression and prognosis, providing new ideas and strategies for the clinical treatment of GDM.
{"title":"Detection and Clinical Significance of Th17/Treg Cell-Related Factors in Patients with Gestational Diabetes Mellitus","authors":"Jinjin Qin, Bei Wang, Chenyuan Cao, Yakun Zhao, Jing Wang, Hongli Wu","doi":"10.26689/par.v7i6.5508","DOIUrl":"https://doi.org/10.26689/par.v7i6.5508","url":null,"abstract":"Objective: To investigate the detection of Th17/Treg cell-related factors in patients with gestational diabetes mellitus (GDM) and its clinical significance. Methods: In this study, a retrospective cohort research method was used to collect the clinical data of 42 patients who were hospitalized in the Affiliated Hospital of Hebei University and received the diagnosis of GDM from January 2018 to December 2022, as well as 42 patients with normal pregnancies during the same period. The Th17/Treg expression levels and metabolism-related indexes in the peripheral blood of patients were detected by radioimmunoassay. Results: The relative expression of Th17 in the serum of patients in the GDM group was significantly higher than that of the control group, and the level of Treg was significantly lower than that of the control group (P < 0.05); the levels of FBG, FINS, 2hBG, TC, TG and HOMA-IR of the patients in the GDM group were significantly higher than that of the control group, and the level of HOMA-β was significantly lower than that of the control group (P < 0.05). Conclusion: The imbalance of the Th17/Treg cell ratio in patients with GDM may be related to their disease progression and prognosis, providing new ideas and strategies for the clinical treatment of GDM.","PeriodicalId":20511,"journal":{"name":"Proceedings of Anticancer Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139249643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To analyze the value of microbiological testing in the treatment of urinary tract infections. Methods:A total of 552 patients with urinary tract infections, diagnosed and treated between January and December 2021, were selected for this study. They were divided into observation and control groups, each consisting of 276 cases, using the random number table method. The observation group underwent microbial testing, while the control group underwent routine examinations to compare the diagnosis rate, overall treatment effectiveness, and infection status between the two groups. Results: The observation group exhibited significantly improved diagnosis rate, treatment effectiveness, and infection status compared to the control group (P < 0.05). Conclusion: The application of microbial testing in the treatment of urinary tract infections demonstrates high clinical applicability.
{"title":"Enhancing Infection Control: A Comprehensive Analysis of Microbial Testing and Clinical Accuracy Assessment","authors":"Lingfeng Lu","doi":"10.26689/par.v7i6.5506","DOIUrl":"https://doi.org/10.26689/par.v7i6.5506","url":null,"abstract":"Objective: To analyze the value of microbiological testing in the treatment of urinary tract infections. Methods:A total of 552 patients with urinary tract infections, diagnosed and treated between January and December 2021, were selected for this study. They were divided into observation and control groups, each consisting of 276 cases, using the random number table method. The observation group underwent microbial testing, while the control group underwent routine examinations to compare the diagnosis rate, overall treatment effectiveness, and infection status between the two groups. Results: The observation group exhibited significantly improved diagnosis rate, treatment effectiveness, and infection status compared to the control group (P < 0.05). Conclusion: The application of microbial testing in the treatment of urinary tract infections demonstrates high clinical applicability.","PeriodicalId":20511,"journal":{"name":"Proceedings of Anticancer Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139248688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In the process of tumor proliferation and metastasis, tumor cells encounter hypoxia, low glucose, acidosis, and other stressful environments. These conditions prompt tumor cells to generate endoplasmic reticulum stress (ERS). As a signal mechanism that mitigates ERS in eukaryotic cells, the unfolded protein response (UPR) pathway can activate cells and tissues, regulating pathological activities in various cells, and maintaining ER homeostasis. It forms the most crucial adaptive and defensive mechanism for cells. However, under the continuous influence of chemotherapy drugs, the quantity of unfolded proteins and erroneous proteins produced by tumor cells significantly increases, surpassing the normal regulatory range of UPR. Consequently, ERS fails to function properly, fostering tumor cell proliferation and the development of drug resistance. This review delves into the study of three UPR pathways (PERK, IRE1, and ATF6), elucidating the mechanisms of drug resistance and research progress in the signal transduction pathway of UPR related to cancers. It provides a profound understanding of the role and relationship between UPR and anti-tumor drugs, offering a new direction for effective clinical treatment.
{"title":"The Role and Mechanism of Unfolded Protein Response Pathway in Tumor Drug Resistance","authors":"Yaqi Han, Bi-Yun Zhou, Haizhi Qiao, Lingyan Wang, Jinku Zhang","doi":"10.26689/par.v7i6.5647","DOIUrl":"https://doi.org/10.26689/par.v7i6.5647","url":null,"abstract":"In the process of tumor proliferation and metastasis, tumor cells encounter hypoxia, low glucose, acidosis, and other stressful environments. These conditions prompt tumor cells to generate endoplasmic reticulum stress (ERS). As a signal mechanism that mitigates ERS in eukaryotic cells, the unfolded protein response (UPR) pathway can activate cells and tissues, regulating pathological activities in various cells, and maintaining ER homeostasis. It forms the most crucial adaptive and defensive mechanism for cells. However, under the continuous influence of chemotherapy drugs, the quantity of unfolded proteins and erroneous proteins produced by tumor cells significantly increases, surpassing the normal regulatory range of UPR. Consequently, ERS fails to function properly, fostering tumor cell proliferation and the development of drug resistance. This review delves into the study of three UPR pathways (PERK, IRE1, and ATF6), elucidating the mechanisms of drug resistance and research progress in the signal transduction pathway of UPR related to cancers. It provides a profound understanding of the role and relationship between UPR and anti-tumor drugs, offering a new direction for effective clinical treatment.","PeriodicalId":20511,"journal":{"name":"Proceedings of Anticancer Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139249013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The endoplasmic reticulum plays an extremely important role in the process of cellular protein secretion. The cyclic AMP-responsive element-binding protein 3 (CREB3) transcription factor family is closely associated with the secretion and transport of proteins within the endoplasmic reticulum. As a member of the CREB3 transcription factor family, cyclic AMP-responsive element-binding protein 3-like protein 2 (CREB3L2) stands out as a non-classical sensor within the endoplasmic reticulum. CREB3L2 can detect and regulate endoplasmic reticulum pressure, exert control over the processes of protein transport and secretion, participate in the development of tumor cells, and is also closely linked to the development of certain human tissues and organs. This article aims to review the role of CREB3L2 in tissue development and disease, shedding light on the related mechanisms of CREB3L2 in cancer development. The goal is to provide insights and directions for further analysis of CREB3L2.
{"title":"The Role of Endoplasmic Reticulum Stress Sensor Protein CREB3L2 in the Development of Tissues and Tumors","authors":"Ziwei Li, Wenming Zhao, Jirui Sun, Lingyan Wang, Jinku Zhang","doi":"10.26689/par.v7i6.5610","DOIUrl":"https://doi.org/10.26689/par.v7i6.5610","url":null,"abstract":"The endoplasmic reticulum plays an extremely important role in the process of cellular protein secretion. The cyclic AMP-responsive element-binding protein 3 (CREB3) transcription factor family is closely associated with the secretion and transport of proteins within the endoplasmic reticulum. As a member of the CREB3 transcription factor family, cyclic AMP-responsive element-binding protein 3-like protein 2 (CREB3L2) stands out as a non-classical sensor within the endoplasmic reticulum. CREB3L2 can detect and regulate endoplasmic reticulum pressure, exert control over the processes of protein transport and secretion, participate in the development of tumor cells, and is also closely linked to the development of certain human tissues and organs. This article aims to review the role of CREB3L2 in tissue development and disease, shedding light on the related mechanisms of CREB3L2 in cancer development. The goal is to provide insights and directions for further analysis of CREB3L2.","PeriodicalId":20511,"journal":{"name":"Proceedings of Anticancer Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139247974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rui Xu, Li Wang, Zhuan Huang, Yurong Zhang, Lingjuan Huang
Objective: To investigate the efficacy of montelukast sodium in the treatment of lung cancer patients with pulmonary infections. Methods: A total of 330 patients diagnosed with lung cancer and pulmonary infection, who were admitted to the First Affiliated Hospital of Xi’an Medical University from 2020 to 2022, were selected as research subjects. They were randomly divided into two groups: a control group receiving conventional treatment and an observation group receiving conventional treatment combined with montelukast sodium. Each group consisted of 165 cases. The time required for clinical symptom improvement, the resolution of lung infection signs, and the levels of serum inflammatory factors before and after treatment were compared between the two groups. Results: The observation group exhibited significantly faster improvement in clinical symptoms compared to the control group (P < 0.001). ELISA assays were conducted to detect the expression levels of IL-1β, IL-6, IL-8, and TNF-α in the serum of both groups at 1 week and 2 weeks into the treatment. The results indicated that, as the treatment progressed, the observation group displayed significantly lower levels of the four serum inflammatory factors compared to the control group (P < 0.001). Conclusion: Montelukast sodium demonstrates efficacy in the treatment of patients with lung cancer complicated by pulmonary infections. These findings suggest its potential for further verification and clinical application.
{"title":"Assessing the Effectiveness of Montelukast Sodium in Managing Pulmonary Infections in Lung Cancer Patients","authors":"Rui Xu, Li Wang, Zhuan Huang, Yurong Zhang, Lingjuan Huang","doi":"10.26689/par.v7i6.5523","DOIUrl":"https://doi.org/10.26689/par.v7i6.5523","url":null,"abstract":"Objective: To investigate the efficacy of montelukast sodium in the treatment of lung cancer patients with pulmonary infections. Methods: A total of 330 patients diagnosed with lung cancer and pulmonary infection, who were admitted to the First Affiliated Hospital of Xi’an Medical University from 2020 to 2022, were selected as research subjects. They were randomly divided into two groups: a control group receiving conventional treatment and an observation group receiving conventional treatment combined with montelukast sodium. Each group consisted of 165 cases. The time required for clinical symptom improvement, the resolution of lung infection signs, and the levels of serum inflammatory factors before and after treatment were compared between the two groups. Results: The observation group exhibited significantly faster improvement in clinical symptoms compared to the control group (P < 0.001). ELISA assays were conducted to detect the expression levels of IL-1β, IL-6, IL-8, and TNF-α in the serum of both groups at 1 week and 2 weeks into the treatment. The results indicated that, as the treatment progressed, the observation group displayed significantly lower levels of the four serum inflammatory factors compared to the control group (P < 0.001). Conclusion: Montelukast sodium demonstrates efficacy in the treatment of patients with lung cancer complicated by pulmonary infections. These findings suggest its potential for further verification and clinical application.","PeriodicalId":20511,"journal":{"name":"Proceedings of Anticancer Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139249087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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