Objective: To analyze the diagnostic value of frozen section pathology in the diagnosis of breast cancer. Methods: A total of 50 patients with breast tumors treated between July 2021 and February 2023 were randomly selected as samples. Both paraffin section and frozen section diagnoses were conducted. The paraffin section results served as the gold standard for evaluating the value of frozen section examination. Results: Among the frozen section diagnoses, 48 cases (96.00%) were confirmed, 1 case was misdiagnosed (2.00%), and 1 case was delayed (2.00%). Among the confirmed patients, 45 cases (90.00%) were entirely consistent, and 3 cases (6.00%) were basically consistent. The diagnostic rate of the frozen section was 96.00%, compared with 100.00% for the paraffin section (P > 0.05). The diagnostic time of the frozen section (35.25 ± 2.11 min) was significantly shorter than that for the paraffin section (6911.36 ± 58.36 min; P < 0.05). Conclusion: Frozen section diagnosis is rapid and demonstrates relatively high diagnostic accuracy. It can guide doctors in determining whether to pursue breast-conserving treatment and aid in selecting appropriate surgical methods. This is beneficial for preventing unnecessary medical interventions and reducing the need for secondary surgeries in breast cancer patients.
{"title":"Examining the Pathological Diagnostic Impact of Frozen Sections in Breast Cancer","authors":"Ying Shen","doi":"10.26689/par.v7i6.5369","DOIUrl":"https://doi.org/10.26689/par.v7i6.5369","url":null,"abstract":"Objective: To analyze the diagnostic value of frozen section pathology in the diagnosis of breast cancer. Methods: A total of 50 patients with breast tumors treated between July 2021 and February 2023 were randomly selected as samples. Both paraffin section and frozen section diagnoses were conducted. The paraffin section results served as the gold standard for evaluating the value of frozen section examination. Results: Among the frozen section diagnoses, 48 cases (96.00%) were confirmed, 1 case was misdiagnosed (2.00%), and 1 case was delayed (2.00%). Among the confirmed patients, 45 cases (90.00%) were entirely consistent, and 3 cases (6.00%) were basically consistent. The diagnostic rate of the frozen section was 96.00%, compared with 100.00% for the paraffin section (P > 0.05). The diagnostic time of the frozen section (35.25 ± 2.11 min) was significantly shorter than that for the paraffin section (6911.36 ± 58.36 min; P < 0.05). Conclusion: Frozen section diagnosis is rapid and demonstrates relatively high diagnostic accuracy. It can guide doctors in determining whether to pursue breast-conserving treatment and aid in selecting appropriate surgical methods. This is beneficial for preventing unnecessary medical interventions and reducing the need for secondary surgeries in breast cancer patients.","PeriodicalId":20511,"journal":{"name":"Proceedings of Anticancer Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139247300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To analyze the impact of sentinel lymph node biopsy (SLNB) combined with breast-conserving surgery in the clinical treatment of early-stage breast cancer. Methods: 80 patients with early-stage breast cancer admitted to the Second Department of Breast Surgery at Dezhou Second People’s Hospital from September 2020 to September 2022 were selected and randomly divided into a control group and an observation group using the random number table method, with 40 cases in each group. The control group underwent a modified radical mastectomy, while the observation group underwent SLNB combined with breast-conserving surgery. The surgical efficacy and prognosis between the two groups were compared. Results: The observation group exhibited shorter operation, hospitalization, and extubation times, as well as less intraoperative blood loss and drainage volume, all of which were significantly better than those in the control group (P < 0.05). Additionally, the observation group demonstrated a higher rate of excellent breast cosmetology and quality of life, with lower complication incidence, significantly outperforming the control group (P < 0.05). There was no statistical difference in the metastasis rate and recurrence rate between the two groups (P > 0.05). Conclusion: The combination of SLNB and breast-conserving surgery proves highly effective for patients with early-stage breast cancer, presenting fewer complications and enhancing both breast cosmetic outcomes and quality of life.
{"title":"Assessing the Clinical Efficacy and Effectiveness of Sentinel Lymph Node Biopsy Combined with Breast-Conserving Surgery for Early-Stage Breast Cancer","authors":"Jiehou Fan","doi":"10.26689/par.v7i6.5649","DOIUrl":"https://doi.org/10.26689/par.v7i6.5649","url":null,"abstract":"Objective: To analyze the impact of sentinel lymph node biopsy (SLNB) combined with breast-conserving surgery in the clinical treatment of early-stage breast cancer. Methods: 80 patients with early-stage breast cancer admitted to the Second Department of Breast Surgery at Dezhou Second People’s Hospital from September 2020 to September 2022 were selected and randomly divided into a control group and an observation group using the random number table method, with 40 cases in each group. The control group underwent a modified radical mastectomy, while the observation group underwent SLNB combined with breast-conserving surgery. The surgical efficacy and prognosis between the two groups were compared. Results: The observation group exhibited shorter operation, hospitalization, and extubation times, as well as less intraoperative blood loss and drainage volume, all of which were significantly better than those in the control group (P < 0.05). Additionally, the observation group demonstrated a higher rate of excellent breast cosmetology and quality of life, with lower complication incidence, significantly outperforming the control group (P < 0.05). There was no statistical difference in the metastasis rate and recurrence rate between the two groups (P > 0.05). Conclusion: The combination of SLNB and breast-conserving surgery proves highly effective for patients with early-stage breast cancer, presenting fewer complications and enhancing both breast cosmetic outcomes and quality of life.","PeriodicalId":20511,"journal":{"name":"Proceedings of Anticancer Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139250063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Deepa Priya R, Aishwarya Lakshmi J, Veena H, K. Shanmugam
Antimicrobial-treated textiles should exhibit efficacy against a broad spectrum of bacterial and fungal species, all while maintaining user safety with a non-toxic profile. Natural antimicrobial compounds play a vital role in textile finishing processes. The proliferation of synthetic antimicrobial agents introduces environmental and consumer safety concerns. Given these potential hazards associated with synthetic agents, the utilization of natural antimicrobial agents is gaining traction, as they tend to have fewer adverse effects on users and are more environmentally sustainable. Numerous natural antimicrobial compounds, sourced from plants such as neem, basil, turmeric, aloe vera, and clove oil, have been developed, showcasing inherent antimicrobial properties. This review article highlights the importance of incorporating bioactive components in the creation of antibacterial textile fabrics.
{"title":"A Review of Textile Fabrication Using Bioactive Compounds Derived from Natural Products","authors":"Deepa Priya R, Aishwarya Lakshmi J, Veena H, K. Shanmugam","doi":"10.26689/par.v7i6.5162","DOIUrl":"https://doi.org/10.26689/par.v7i6.5162","url":null,"abstract":"Antimicrobial-treated textiles should exhibit efficacy against a broad spectrum of bacterial and fungal species, all while maintaining user safety with a non-toxic profile. Natural antimicrobial compounds play a vital role in textile finishing processes. The proliferation of synthetic antimicrobial agents introduces environmental and consumer safety concerns. Given these potential hazards associated with synthetic agents, the utilization of natural antimicrobial agents is gaining traction, as they tend to have fewer adverse effects on users and are more environmentally sustainable. Numerous natural antimicrobial compounds, sourced from plants such as neem, basil, turmeric, aloe vera, and clove oil, have been developed, showcasing inherent antimicrobial properties. This review article highlights the importance of incorporating bioactive components in the creation of antibacterial textile fabrics.","PeriodicalId":20511,"journal":{"name":"Proceedings of Anticancer Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139286004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To analyze the screening effectiveness of combining the fecal occult blood test with tumor marker detection for colorectal cancer. Methods: A total of thirty patients with colorectal cancer and thirty patients with benign colon hyperplasia who received treatment from January 2020 to January 2023 were selected. These patients were assigned to the observation group and the control group, respectively. All patients in both groups underwent both fecal occult blood tests and tumor marker detection. The levels of tumor markers between the two groups were compared, the tumor marker levels in different stages were assessed within the observation group, and the positive detection rates for single detection and combined detection were compared. Results: The levels of various tumor markers in the observation group were significantly higher than those in the control group (P < 0.05). Furthermore, as the Duke stage increased within the observation group, the levels of various tumor markers also increased (P < 0.05). The positive detection rate of the combined test was notably higher than that of single detection (P < 0.05). Conclusion: Combining the fecal occult blood test with tumor marker detection in colorectal cancer screening can significantly improve the overall detection rate.
{"title":"Evaluating the Efficacy of Fecal Occult Blood Test and Tumor Marker Combined Screening for Colorectal Cancer","authors":"Yuan Yu","doi":"10.26689/par.v7i6.5567","DOIUrl":"https://doi.org/10.26689/par.v7i6.5567","url":null,"abstract":"Objective: To analyze the screening effectiveness of combining the fecal occult blood test with tumor marker detection for colorectal cancer. Methods: A total of thirty patients with colorectal cancer and thirty patients with benign colon hyperplasia who received treatment from January 2020 to January 2023 were selected. These patients were assigned to the observation group and the control group, respectively. All patients in both groups underwent both fecal occult blood tests and tumor marker detection. The levels of tumor markers between the two groups were compared, the tumor marker levels in different stages were assessed within the observation group, and the positive detection rates for single detection and combined detection were compared. Results: The levels of various tumor markers in the observation group were significantly higher than those in the control group (P < 0.05). Furthermore, as the Duke stage increased within the observation group, the levels of various tumor markers also increased (P < 0.05). The positive detection rate of the combined test was notably higher than that of single detection (P < 0.05). Conclusion: Combining the fecal occult blood test with tumor marker detection in colorectal cancer screening can significantly improve the overall detection rate.","PeriodicalId":20511,"journal":{"name":"Proceedings of Anticancer Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135544566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To survey and study the emergency response capabilities of grassroots disease control institutions in a certain area for public health emergencies, and to put forward suggestions for rectification. Methods: The study was carried out from March 2022 to March 2023. Field surveys, questionnaire surveys, and interviews were used to investigate and analyze the emergency response capabilities of public health emergencies in 5 county Centers for Disease Control and Prevention (CDCs) in the region. Results: Through the survey, it was found that the professional level of the existing emergency team personnel of the grassroots disease control institutions in this region needs to be improved. There was an overall lack of emergency plans, and the compliance rate of the equipment, inspection, and testing items was low. The health emergency system of the CDCs in the region and the ability of the talent team need to be further improved. Conclusion: The emergency response capacity of grassroots disease control institutions in this region needs to be improved. For this reason, government departments need to increase investment and strengthen the construction of talent teams and hardware settings, and grassroots disease control institutions need to strengthen the construction of the public health emergency system to improve the ability to respond to public health emergencies.
{"title":"Survey on the Status Quo of Emergency Response Capabilities of Public Health Emergencies in Grassroots Disease Control Institutions in a Certain Area","authors":"Zhaohua Jiang","doi":"10.26689/par.v7i5.5309","DOIUrl":"https://doi.org/10.26689/par.v7i5.5309","url":null,"abstract":"Objective: To survey and study the emergency response capabilities of grassroots disease control institutions in a certain area for public health emergencies, and to put forward suggestions for rectification. Methods: The study was carried out from March 2022 to March 2023. Field surveys, questionnaire surveys, and interviews were used to investigate and analyze the emergency response capabilities of public health emergencies in 5 county Centers for Disease Control and Prevention (CDCs) in the region. Results: Through the survey, it was found that the professional level of the existing emergency team personnel of the grassroots disease control institutions in this region needs to be improved. There was an overall lack of emergency plans, and the compliance rate of the equipment, inspection, and testing items was low. The health emergency system of the CDCs in the region and the ability of the talent team need to be further improved. Conclusion: The emergency response capacity of grassroots disease control institutions in this region needs to be improved. For this reason, government departments need to increase investment and strengthen the construction of talent teams and hardware settings, and grassroots disease control institutions need to strengthen the construction of the public health emergency system to improve the ability to respond to public health emergencies.","PeriodicalId":20511,"journal":{"name":"Proceedings of Anticancer Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135864453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To compare the effect of L-asparaginase and pegaspargase in the treatment of adult acute lymphoblastic leukemia. Methods: In this study, 96 patients who received treatment at the Shaanxi Provincial People’s Hospital from April 2019 to April 2021 were selected. The control group received L-asparaginase treatment, and the observation group received pegaspargase treatment. The curative effect and adverse reaction rate were compared between the two groups. Results: Comparing the experimental statistical results of the observation and the control groups, it can be concluded that the effect of the former group is better than that of the latter group in terms of clinical curative effect and statistics of adverse reactions. Conclusion: In the treatment of adult acute lymphoblastic leukemia, the application of pegaspargase therapy has a significantly better clinical effect and is worthy of further promotion.
{"title":"Comparison of the Effects of L-asparaginase and Pegaspargase in the Treatment of Adult Acute Lymphoblastic Leukemia","authors":"Limin Hou, Lan Li","doi":"10.26689/par.v7i5.5157","DOIUrl":"https://doi.org/10.26689/par.v7i5.5157","url":null,"abstract":"Objective: To compare the effect of L-asparaginase and pegaspargase in the treatment of adult acute lymphoblastic leukemia. Methods: In this study, 96 patients who received treatment at the Shaanxi Provincial People’s Hospital from April 2019 to April 2021 were selected. The control group received L-asparaginase treatment, and the observation group received pegaspargase treatment. The curative effect and adverse reaction rate were compared between the two groups. Results: Comparing the experimental statistical results of the observation and the control groups, it can be concluded that the effect of the former group is better than that of the latter group in terms of clinical curative effect and statistics of adverse reactions. Conclusion: In the treatment of adult acute lymphoblastic leukemia, the application of pegaspargase therapy has a significantly better clinical effect and is worthy of further promotion.","PeriodicalId":20511,"journal":{"name":"Proceedings of Anticancer Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135770026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Advanced gastric cancer is a common digestive system tumor, and its treatment has always been a difficult problem. In recent years, with the rapid development of immunotherapy, the treatment effect of advanced gastric cancer has been significantly improved. This article introduces the current status and clinical research progress of immune checkpoint inhibitors in advanced gastric cancer. Commonly used immunotherapy methods include chemical drug therapy, biological therapy, and gene therapy, among which the immune checkpoint inhibitors are currently one of the most popular immunotherapy methods, including nivolumab, pembrolizumab, and atezolizumab, which target programmed death ligand 1 (PD-L1) low expression (1%–49%) and PD-L1 high expression (≥50%). The results of clinical studies have shown that immunotherapy can significantly prolong the survival of patients with advanced gastric cancer while having lower toxic side effects and better tolerance. However, immunotherapy also has some problems, such as drug resistance and repeated infection. Future research directions include exploring new immunotherapy methods, combination therapy, and individualized therapy.
{"title":"Current Status and Clinical Research Progress of Immunotherapy for Advanced Gastric Cancer","authors":"Jiaxin Wang","doi":"10.26689/par.v7i5.5245","DOIUrl":"https://doi.org/10.26689/par.v7i5.5245","url":null,"abstract":"Advanced gastric cancer is a common digestive system tumor, and its treatment has always been a difficult problem. In recent years, with the rapid development of immunotherapy, the treatment effect of advanced gastric cancer has been significantly improved. This article introduces the current status and clinical research progress of immune checkpoint inhibitors in advanced gastric cancer. Commonly used immunotherapy methods include chemical drug therapy, biological therapy, and gene therapy, among which the immune checkpoint inhibitors are currently one of the most popular immunotherapy methods, including nivolumab, pembrolizumab, and atezolizumab, which target programmed death ligand 1 (PD-L1) low expression (1%–49%) and PD-L1 high expression (≥50%). The results of clinical studies have shown that immunotherapy can significantly prolong the survival of patients with advanced gastric cancer while having lower toxic side effects and better tolerance. However, immunotherapy also has some problems, such as drug resistance and repeated infection. Future research directions include exploring new immunotherapy methods, combination therapy, and individualized therapy.","PeriodicalId":20511,"journal":{"name":"Proceedings of Anticancer Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135864076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To investigate the impact of sarcopenia on the prognosis of frail elderly patients with chronic kidney disease. Methods: A total of 98 elderly frail patients with chronic kidney disease were included in this study from June 2020 to July 2022. The patients were randomly divided into a study group of 48 cases and a control group of 50 cases. The control group only received conventional treatment for chronic kidney disease. On the basis of conventional treatment for chronic kidney disease, the study group added sarcopenia intervention treatment. The quality-of-life scores, muscle mass and muscle strength, renal function, and incidence of complications of the two groups were observed and analyzed. Results: The quality-of-life score, muscle mass and muscle strength, and renal function of the study group were significantly better than those of the control group (P < 0.05); the incidence of complications in the study group was 12.5%, which was significantly lower than that of the control group 36% of the group (P < 0.05). Conclusion: There is a close relationship between sarcopenia and frail elderly patients with chronic kidney disease. Sarcopenia will further aggravate the frailty symptoms and increase the risk of complications in elderly patients with chronic kidney disease. For elderly patients with chronic kidney disease, sarcopenia should be screened and intervened as early as possible to improve the prognosis and quality of life of the patients.
{"title":"Impact of Sarcopenia on Prognosis in Frail Elderly Patients with Chronic Kidney Disease","authors":"Lei Ran, Lei Wang, Tingting Cai","doi":"10.26689/par.v7i5.5261","DOIUrl":"https://doi.org/10.26689/par.v7i5.5261","url":null,"abstract":"Objective: To investigate the impact of sarcopenia on the prognosis of frail elderly patients with chronic kidney disease. Methods: A total of 98 elderly frail patients with chronic kidney disease were included in this study from June 2020 to July 2022. The patients were randomly divided into a study group of 48 cases and a control group of 50 cases. The control group only received conventional treatment for chronic kidney disease. On the basis of conventional treatment for chronic kidney disease, the study group added sarcopenia intervention treatment. The quality-of-life scores, muscle mass and muscle strength, renal function, and incidence of complications of the two groups were observed and analyzed. Results: The quality-of-life score, muscle mass and muscle strength, and renal function of the study group were significantly better than those of the control group (P < 0.05); the incidence of complications in the study group was 12.5%, which was significantly lower than that of the control group 36% of the group (P < 0.05). Conclusion: There is a close relationship between sarcopenia and frail elderly patients with chronic kidney disease. Sarcopenia will further aggravate the frailty symptoms and increase the risk of complications in elderly patients with chronic kidney disease. For elderly patients with chronic kidney disease, sarcopenia should be screened and intervened as early as possible to improve the prognosis and quality of life of the patients.","PeriodicalId":20511,"journal":{"name":"Proceedings of Anticancer Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135864633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tingting Li, Jia Feng, Qian Sun, Yanhong Shang, Youchao Jia, Kebin Zheng, Ce Wang, Jing Li, Yanling Li
Purpose: To study the adverse effects of frailty on elderly cancer patients and explore effective interventions. Methods: The convenience sampling method was used to select 362 elderly cancer patients who were consecutively admitted to the Oncology Department of the Affiliated Hospital of Hebei University from April 2020 to March 2021. The patients had five physical dimensions of activity tested and were divided into a frail group (n = 128) and a non-frail group (n = 234) based on the test results. The Chinese version of the Vulnerable Elders Questionnaire was formed on the basis of the Vulnerable Elders Survey-13 (VES-13). The two groups of patients were surveyed within three days of admission. The questionnaire includes general information (age, gender, education level, marital status, monthly income, living area, smoking, and alcohol history, hearing, vision, and sleep status), Geriatric Depression Scale (GDS), Mini Nutritional Assessment (MNA), Mini-Mental State Examination (MMSE), and Charlson Comorbidity Index (CCI). Results: (1) By comparing the general information of the two groups of patients, it was found that the gender, education level, marital status, living area, and history of tobacco and alcohol had no statistical significance (P > 0.05). In contrast, the frail group’s age, hearing status, vision status, and sleep status are significantly worse than those of the non-frail group (P < 0.05); (2) Analysis of Vulnerable Elderly Questionnaire results found that the GDS scores in the frail group were higher than those in the non-frail group, and the MNA and MMSE scores were lower than those in the non-frail group (P < 0.05). This indicated that the patients in the frail group had more severe depression, poor nutritional status, and specific impairments in cognitive function. Conclusion: Frailty adversely affects elderly cancer patients, and effective measures should be taken to intervene.
{"title":"Adverse Effects and Intervention of Frailty on Elderly Cancer Patients","authors":"Tingting Li, Jia Feng, Qian Sun, Yanhong Shang, Youchao Jia, Kebin Zheng, Ce Wang, Jing Li, Yanling Li","doi":"10.26689/par.v7i5.5394","DOIUrl":"https://doi.org/10.26689/par.v7i5.5394","url":null,"abstract":"Purpose: To study the adverse effects of frailty on elderly cancer patients and explore effective interventions. Methods: The convenience sampling method was used to select 362 elderly cancer patients who were consecutively admitted to the Oncology Department of the Affiliated Hospital of Hebei University from April 2020 to March 2021. The patients had five physical dimensions of activity tested and were divided into a frail group (n = 128) and a non-frail group (n = 234) based on the test results. The Chinese version of the Vulnerable Elders Questionnaire was formed on the basis of the Vulnerable Elders Survey-13 (VES-13). The two groups of patients were surveyed within three days of admission. The questionnaire includes general information (age, gender, education level, marital status, monthly income, living area, smoking, and alcohol history, hearing, vision, and sleep status), Geriatric Depression Scale (GDS), Mini Nutritional Assessment (MNA), Mini-Mental State Examination (MMSE), and Charlson Comorbidity Index (CCI). Results: (1) By comparing the general information of the two groups of patients, it was found that the gender, education level, marital status, living area, and history of tobacco and alcohol had no statistical significance (P > 0.05). In contrast, the frail group’s age, hearing status, vision status, and sleep status are significantly worse than those of the non-frail group (P < 0.05); (2) Analysis of Vulnerable Elderly Questionnaire results found that the GDS scores in the frail group were higher than those in the non-frail group, and the MNA and MMSE scores were lower than those in the non-frail group (P < 0.05). This indicated that the patients in the frail group had more severe depression, poor nutritional status, and specific impairments in cognitive function. Conclusion: Frailty adversely affects elderly cancer patients, and effective measures should be taken to intervene.","PeriodicalId":20511,"journal":{"name":"Proceedings of Anticancer Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135865893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Saranya N, Sri Abarajitha R, Anandhasayanan T, Jaivignesh D, Mugunthan B, Yuvaraj Dinakarkumar, Kirubanandan Shanmugam
Lately there has been a lot of interest worldwide in studies on the antiviral activities of marine natural secondary metabolites, notably marine polysaccharides. It has been established that polysaccharides made from marine sources and their derivatives have antiviral effects against potent viruses. Agricultural, biological, food, and pharmaceutical industries all make extensive use of goods obtained from algae. The most well-known chemical components found in algae are polysaccharides, which have been the subject of a variety of studies because of their varied bioactivities. Polysaccharides made from algae have recently risen to the top of pharmaceutical research due to their fascinating antiviral potential. Currently, COVID-19 can be prevented with vaccination, but the brown alga Sargassum wightii has several bioactive compounds that have the following qualities and may be a better option. S. wightii is one of the marine algae species that is rich in sulfated polysaccharides, the secondary metabolites which have antiviral action and the capacity to prevent viral proliferation. Fucoidan, a long-chain sulfated polysaccharide found in various brown algae, has potent antiviral effects. Additionally, sulfated polysaccharides from green algae (such as ulvans) and red algae (such as carrageenan), and lectins from red algae (such as griffithsin) have antiviral therapeutic agents against coronaviruses and other viruses. This research focuses on screening seaweeds for possible antiviral compounds to treat viral infections notably COVID-19.
{"title":"Screening of Antiviral Efficacy of Few Seaweeds of Tamil Nadu Coast","authors":"Saranya N, Sri Abarajitha R, Anandhasayanan T, Jaivignesh D, Mugunthan B, Yuvaraj Dinakarkumar, Kirubanandan Shanmugam","doi":"10.26689/par.v7i5.5161","DOIUrl":"https://doi.org/10.26689/par.v7i5.5161","url":null,"abstract":"Lately there has been a lot of interest worldwide in studies on the antiviral activities of marine natural secondary metabolites, notably marine polysaccharides. It has been established that polysaccharides made from marine sources and their derivatives have antiviral effects against potent viruses. Agricultural, biological, food, and pharmaceutical industries all make extensive use of goods obtained from algae. The most well-known chemical components found in algae are polysaccharides, which have been the subject of a variety of studies because of their varied bioactivities. Polysaccharides made from algae have recently risen to the top of pharmaceutical research due to their fascinating antiviral potential. Currently, COVID-19 can be prevented with vaccination, but the brown alga Sargassum wightii has several bioactive compounds that have the following qualities and may be a better option. S. wightii is one of the marine algae species that is rich in sulfated polysaccharides, the secondary metabolites which have antiviral action and the capacity to prevent viral proliferation. Fucoidan, a long-chain sulfated polysaccharide found in various brown algae, has potent antiviral effects. Additionally, sulfated polysaccharides from green algae (such as ulvans) and red algae (such as carrageenan), and lectins from red algae (such as griffithsin) have antiviral therapeutic agents against coronaviruses and other viruses. This research focuses on screening seaweeds for possible antiviral compounds to treat viral infections notably COVID-19.","PeriodicalId":20511,"journal":{"name":"Proceedings of Anticancer Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135864612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：