Pub Date : 2012-10-09DOI: 10.3724/SP.J.1206.2011.00429
Li Yang, Ling Xiao, Linxun Chen
{"title":"Research Progress of Autophagy and Pulmonary Diseases*: Research Progress of Autophagy and Pulmonary Diseases*","authors":"Li Yang, Ling Xiao, Linxun Chen","doi":"10.3724/SP.J.1206.2011.00429","DOIUrl":"https://doi.org/10.3724/SP.J.1206.2011.00429","url":null,"abstract":"","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":"73 1","pages":"861-868"},"PeriodicalIF":0.3,"publicationDate":"2012-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86122554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-10-01DOI: 10.3724/sp.j.1206.2011.00519
Li Jing, Lin Zhu-mei, Zhu Li-qi
Autism spectrum disorder (ASD) is a defective mental disease and its core impairments are social function defect, communication defect, restrictive and stereotyped behavior pattern. The paper introduces the genetic basis and neural mechanism of ASD. ASD has high genetic rate, and 5-HT and testosterone of ASD individual are both higher. Neuroimaging studies find that there are some differences between ASD and normal individuals in the structure and function of amygdala, cingulate gyrus, the fusiform gyrus, mirror neurons, prefrontal lobe and other brain areas, but it is inconsistent in the discrepancy direction of some areas' activation patterns. In addition, the results of functional connectivity studies also confirm the hypothesis that the ASD individuals are under-connection. Future research should focus more on how to use the basic research outcomes to put forward effective treatment and training for clinical research.
{"title":"Genetic Basis and Neural Mechanism of Autism Spectrum Disorder","authors":"Li Jing, Lin Zhu-mei, Zhu Li-qi","doi":"10.3724/sp.j.1206.2011.00519","DOIUrl":"https://doi.org/10.3724/sp.j.1206.2011.00519","url":null,"abstract":"Autism spectrum disorder (ASD) is a defective mental disease and its core impairments are social function defect, communication defect, restrictive and stereotyped behavior pattern. The paper introduces the genetic basis and neural mechanism of ASD. ASD has high genetic rate, and 5-HT and testosterone of ASD individual are both higher. Neuroimaging studies find that there are some differences between ASD and normal individuals in the structure and function of amygdala, cingulate gyrus, the fusiform gyrus, mirror neurons, prefrontal lobe and other brain areas, but it is inconsistent in the discrepancy direction of some areas' activation patterns. In addition, the results of functional connectivity studies also confirm the hypothesis that the ASD individuals are under-connection. Future research should focus more on how to use the basic research outcomes to put forward effective treatment and training for clinical research.","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":"37 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2012-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80336062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-09-03DOI: 10.3724/SP.J.1206.2012.00097
N. Chen, L. Dai, Yuwu Jiang, Ye Wu
{"title":"Pathogenic Role of UPR (Unfolded Protein Response) Among Hereditary Leukoencephalopathy and Neurodegenerative Disorders After Endoplasmic Reticulum Stress*: Pathogenic Role of UPR (Unfolded Protein Response) Among Hereditary Leukoencephalopathy and Neurodegenerative Disorders After Endoplasmic Retic","authors":"N. Chen, L. Dai, Yuwu Jiang, Ye Wu","doi":"10.3724/SP.J.1206.2012.00097","DOIUrl":"https://doi.org/10.3724/SP.J.1206.2012.00097","url":null,"abstract":"","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":"24 1","pages":"764-770"},"PeriodicalIF":0.3,"publicationDate":"2012-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72732477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-09-03DOI: 10.3724/SP.J.1206.2012.00275
Jiankang Liu, Yunhua Peng, J. Long
{"title":"The Role of Brain Mitochondrial Estrogen Receptor β in The Pathogensis of Female Alzheimer′s Disease*: The Role of Brain Mitochondrial Estrogen Receptor β in The Pathogensis of Female Alzheimer′s Disease*","authors":"Jiankang Liu, Yunhua Peng, J. Long","doi":"10.3724/SP.J.1206.2012.00275","DOIUrl":"https://doi.org/10.3724/SP.J.1206.2012.00275","url":null,"abstract":"","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":"33 1","pages":"785-790"},"PeriodicalIF":0.3,"publicationDate":"2012-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88428275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-09-03DOI: 10.3724/SP.J.1206.2012.00215
Qian Hua, Hai-min Ding, Mi Liang
{"title":"Progress on Aβ-Targeted Therapeutic Strategies for Alzheimer′s Disease*: Progress on Aβ-Targeted Therapeutic Strategies for Alzheimer′s Disease*","authors":"Qian Hua, Hai-min Ding, Mi Liang","doi":"10.3724/SP.J.1206.2012.00215","DOIUrl":"https://doi.org/10.3724/SP.J.1206.2012.00215","url":null,"abstract":"","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":"26 1","pages":"734-740"},"PeriodicalIF":0.3,"publicationDate":"2012-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83639259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-09-03DOI: 10.3724/SP.J.1206.2012.00316
D. Yin, Wenfei Liu
{"title":"Carbonyl Stress, Aging Mechanisms, and The Up-stream Molecular Etiology of Alzheimer′s Disease*: Carbonyl Stress, Aging Mechanisms, and The Up-stream Molecular Etiology of Alzheimer′s Disease*","authors":"D. Yin, Wenfei Liu","doi":"10.3724/SP.J.1206.2012.00316","DOIUrl":"https://doi.org/10.3724/SP.J.1206.2012.00316","url":null,"abstract":"","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":"100 1","pages":"747-755"},"PeriodicalIF":0.3,"publicationDate":"2012-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76372339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-09-03DOI: 10.3724/SP.J.1206.2012.00297
Zhao Baolu, 赵保路, Wan Li
{"title":"Metal Metabolic Homeostasis Disruption and Early Initiation of Mechanism for Alzheimer's Disease","authors":"Zhao Baolu, 赵保路, Wan Li","doi":"10.3724/SP.J.1206.2012.00297","DOIUrl":"https://doi.org/10.3724/SP.J.1206.2012.00297","url":null,"abstract":"","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":"47 1","pages":"756-763"},"PeriodicalIF":0.3,"publicationDate":"2012-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78201318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-09-03DOI: 10.3724/SP.J.1206.2012.00363
Zhi‐Xue Liu, Jie Chen, De-Yi Zhang
{"title":"The Mechanism of Autophagy Regulation and The Role of Autophagy in Alzheimer′s Disease*: The Mechanism of Autophagy Regulation and The Role of Autophagy in Alzheimer′s Disease*","authors":"Zhi‐Xue Liu, Jie Chen, De-Yi Zhang","doi":"10.3724/SP.J.1206.2012.00363","DOIUrl":"https://doi.org/10.3724/SP.J.1206.2012.00363","url":null,"abstract":"","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":"5 1","pages":"726-733"},"PeriodicalIF":0.3,"publicationDate":"2012-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78420848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-09-03DOI: 10.3724/SP.J.1206.2012.00365
Yan-fei Wei, Junye Miao, Y. Liu
{"title":"Endogenous and Exogenous Factors in Hyperphosphorylation of Tau in Alzheimer′s Disease*: Endogenous and Exogenous Factors in Hyperphosphorylation of Tau in Alzheimer′s Disease*","authors":"Yan-fei Wei, Junye Miao, Y. Liu","doi":"10.3724/SP.J.1206.2012.00365","DOIUrl":"https://doi.org/10.3724/SP.J.1206.2012.00365","url":null,"abstract":"","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":"125 1","pages":"778-784"},"PeriodicalIF":0.3,"publicationDate":"2012-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75743481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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