Pub Date : 2012-11-15DOI: 10.3724/SP.J.1206.2011.00567
Jinjun He, Chuanjun Liu, Danhui Liu, Ji-fu Liu, Shanshan Wu, Xue-yuan Xiao, D. He
{"title":"PROL4 Elevates The Sensitivity of Lung Cancer Cell LTEP-a-2 to Cisplatin Treatment*: PROL4 Elevates The Sensitivity of Lung Cancer Cell LTEP-a-2 to Cisplatin Treatment*","authors":"Jinjun He, Chuanjun Liu, Danhui Liu, Ji-fu Liu, Shanshan Wu, Xue-yuan Xiao, D. He","doi":"10.3724/SP.J.1206.2011.00567","DOIUrl":"https://doi.org/10.3724/SP.J.1206.2011.00567","url":null,"abstract":"","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2012-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83533311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-11-01DOI: 10.3724/SP.J.1206.2011.00442
Liang Kai-yun, Fu Qiufang, Fu Xiaolan
In probabilistic category learning tasks, people learn incrementally the "probabilistic" association between cues and outcomes. Here, we first discussed cognitive strategies used in probabilistic category learning, the unconsciousness of probabilistic category learning, as well as the relationship between probabilistic category learning and working memory and attention. Then, we reviewed the different roles of various brain regions, including the basal ganglia, the medial temporal lobe, the prefrontal lobe and the parietal lobe, in probabilistic category learning. Finally, we suggest that probabilistic category learning might involve both implicit and explicit processes and future research is needed to further explore the cognitive and neural mechanisms of probabilistic category learning.
{"title":"Cognitive and Neural Mechanisms of Probabilistic Category Learning*: Cognitive and Neural Mechanisms of Probabilistic Category Learning*","authors":"Liang Kai-yun, Fu Qiufang, Fu Xiaolan","doi":"10.3724/SP.J.1206.2011.00442","DOIUrl":"https://doi.org/10.3724/SP.J.1206.2011.00442","url":null,"abstract":"In probabilistic category learning tasks, people learn incrementally the \"probabilistic\" association between cues and outcomes. Here, we first discussed cognitive strategies used in probabilistic category learning, the unconsciousness of probabilistic category learning, as well as the relationship between probabilistic category learning and working memory and attention. Then, we reviewed the different roles of various brain regions, including the basal ganglia, the medial temporal lobe, the prefrontal lobe and the parietal lobe, in probabilistic category learning. Finally, we suggest that probabilistic category learning might involve both implicit and explicit processes and future research is needed to further explore the cognitive and neural mechanisms of probabilistic category learning.","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81583139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-10-09DOI: 10.3724/SP.J.1206.2011.00252
Hui Liu, Ziheng Zhuang, J. Guan, Shuigeng Zhou
{"title":"Transcriptional Regulation Functions of Nucleosome Positioning: a Survey*: Transcriptional Regulation Functions of Nucleosome Positioning: a Survey*","authors":"Hui Liu, Ziheng Zhuang, J. Guan, Shuigeng Zhou","doi":"10.3724/SP.J.1206.2011.00252","DOIUrl":"https://doi.org/10.3724/SP.J.1206.2011.00252","url":null,"abstract":"","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2012-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90521160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-10-09DOI: 10.3724/SP.J.1206.2011.00429
Li Yang, Ling Xiao, Linxun Chen
{"title":"Research Progress of Autophagy and Pulmonary Diseases*: Research Progress of Autophagy and Pulmonary Diseases*","authors":"Li Yang, Ling Xiao, Linxun Chen","doi":"10.3724/SP.J.1206.2011.00429","DOIUrl":"https://doi.org/10.3724/SP.J.1206.2011.00429","url":null,"abstract":"","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2012-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86122554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-10-01DOI: 10.3724/sp.j.1206.2011.00519
Li Jing, Lin Zhu-mei, Zhu Li-qi
Autism spectrum disorder (ASD) is a defective mental disease and its core impairments are social function defect, communication defect, restrictive and stereotyped behavior pattern. The paper introduces the genetic basis and neural mechanism of ASD. ASD has high genetic rate, and 5-HT and testosterone of ASD individual are both higher. Neuroimaging studies find that there are some differences between ASD and normal individuals in the structure and function of amygdala, cingulate gyrus, the fusiform gyrus, mirror neurons, prefrontal lobe and other brain areas, but it is inconsistent in the discrepancy direction of some areas' activation patterns. In addition, the results of functional connectivity studies also confirm the hypothesis that the ASD individuals are under-connection. Future research should focus more on how to use the basic research outcomes to put forward effective treatment and training for clinical research.
{"title":"Genetic Basis and Neural Mechanism of Autism Spectrum Disorder","authors":"Li Jing, Lin Zhu-mei, Zhu Li-qi","doi":"10.3724/sp.j.1206.2011.00519","DOIUrl":"https://doi.org/10.3724/sp.j.1206.2011.00519","url":null,"abstract":"Autism spectrum disorder (ASD) is a defective mental disease and its core impairments are social function defect, communication defect, restrictive and stereotyped behavior pattern. The paper introduces the genetic basis and neural mechanism of ASD. ASD has high genetic rate, and 5-HT and testosterone of ASD individual are both higher. Neuroimaging studies find that there are some differences between ASD and normal individuals in the structure and function of amygdala, cingulate gyrus, the fusiform gyrus, mirror neurons, prefrontal lobe and other brain areas, but it is inconsistent in the discrepancy direction of some areas' activation patterns. In addition, the results of functional connectivity studies also confirm the hypothesis that the ASD individuals are under-connection. Future research should focus more on how to use the basic research outcomes to put forward effective treatment and training for clinical research.","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2012-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80336062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-09-03DOI: 10.3724/SP.J.1206.2012.00097
N. Chen, L. Dai, Yuwu Jiang, Ye Wu
{"title":"Pathogenic Role of UPR (Unfolded Protein Response) Among Hereditary Leukoencephalopathy and Neurodegenerative Disorders After Endoplasmic Reticulum Stress*: Pathogenic Role of UPR (Unfolded Protein Response) Among Hereditary Leukoencephalopathy and Neurodegenerative Disorders After Endoplasmic Retic","authors":"N. Chen, L. Dai, Yuwu Jiang, Ye Wu","doi":"10.3724/SP.J.1206.2012.00097","DOIUrl":"https://doi.org/10.3724/SP.J.1206.2012.00097","url":null,"abstract":"","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2012-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72732477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-09-03DOI: 10.3724/SP.J.1206.2012.00275
Jiankang Liu, Yunhua Peng, J. Long
{"title":"The Role of Brain Mitochondrial Estrogen Receptor β in The Pathogensis of Female Alzheimer′s Disease*: The Role of Brain Mitochondrial Estrogen Receptor β in The Pathogensis of Female Alzheimer′s Disease*","authors":"Jiankang Liu, Yunhua Peng, J. Long","doi":"10.3724/SP.J.1206.2012.00275","DOIUrl":"https://doi.org/10.3724/SP.J.1206.2012.00275","url":null,"abstract":"","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2012-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88428275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-09-03DOI: 10.3724/SP.J.1206.2012.00215
Qian Hua, Hai-min Ding, Mi Liang
{"title":"Progress on Aβ-Targeted Therapeutic Strategies for Alzheimer′s Disease*: Progress on Aβ-Targeted Therapeutic Strategies for Alzheimer′s Disease*","authors":"Qian Hua, Hai-min Ding, Mi Liang","doi":"10.3724/SP.J.1206.2012.00215","DOIUrl":"https://doi.org/10.3724/SP.J.1206.2012.00215","url":null,"abstract":"","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2012-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83639259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-09-03DOI: 10.3724/SP.J.1206.2012.00316
D. Yin, Wenfei Liu
{"title":"Carbonyl Stress, Aging Mechanisms, and The Up-stream Molecular Etiology of Alzheimer′s Disease*: Carbonyl Stress, Aging Mechanisms, and The Up-stream Molecular Etiology of Alzheimer′s Disease*","authors":"D. Yin, Wenfei Liu","doi":"10.3724/SP.J.1206.2012.00316","DOIUrl":"https://doi.org/10.3724/SP.J.1206.2012.00316","url":null,"abstract":"","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2012-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76372339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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