Pub Date : 2012-09-03DOI: 10.3724/SP.J.1206.2012.00134
Lu Lin, Shu‐jun Xu, Qinwen Wang
Alzheimer′s disease(AD),which is characterized with acquired deterioration of cognitive functioning and neuronal loss,is the most common neurodegenerative disease in the elderly population.However,the pathogenesis of AD is still unclear.The accumulation of β-amyloid protein(Aβ) in the brains has been associated with pathogenesis of AD.Studies have shown that astrocytes,the most abundant cells in the central nervous system(CNS),play an important role in the cause and progression of AD by regulating the metabolism of Aβ.The present paper reviews the production,internalization and degradation of Aβ in astrocytes.Our goal is to provide updated views of the role and mechanism of astrocytes in the metabolism of Aβ and its role in pathogenesis in the early stages of Alzheimer′s disease.
{"title":"The Relationship Between Astrocyte-mediated Metabolism of β-Amyloid Protein and Pathogenesis of The Early Stages of Alzheimer′s Disease*: The Relationship Between Astrocyte-mediated Metabolism of β-Amyloid Protein and Pathogenesis of The Early Stages of Alzheimer′s Disease*","authors":"Lu Lin, Shu‐jun Xu, Qinwen Wang","doi":"10.3724/SP.J.1206.2012.00134","DOIUrl":"https://doi.org/10.3724/SP.J.1206.2012.00134","url":null,"abstract":"Alzheimer′s disease(AD),which is characterized with acquired deterioration of cognitive functioning and neuronal loss,is the most common neurodegenerative disease in the elderly population.However,the pathogenesis of AD is still unclear.The accumulation of β-amyloid protein(Aβ) in the brains has been associated with pathogenesis of AD.Studies have shown that astrocytes,the most abundant cells in the central nervous system(CNS),play an important role in the cause and progression of AD by regulating the metabolism of Aβ.The present paper reviews the production,internalization and degradation of Aβ in astrocytes.Our goal is to provide updated views of the role and mechanism of astrocytes in the metabolism of Aβ and its role in pathogenesis in the early stages of Alzheimer′s disease.","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":"38 1","pages":"715-720"},"PeriodicalIF":0.3,"publicationDate":"2012-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87248288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-09-03DOI: 10.3724/SP.J.1206.2012.00210
J. Jia, Fen Wang, Q. Yuan, W. Qin, Yi Tnag, Xiu-mei Zuo, Yue Han
{"title":"Progresses on Genetics of Predementia Phase of Alzheimer′s Disease*: Progresses on Genetics of Predementia Phase of Alzheimer′s Disease*","authors":"J. Jia, Fen Wang, Q. Yuan, W. Qin, Yi Tnag, Xiu-mei Zuo, Yue Han","doi":"10.3724/SP.J.1206.2012.00210","DOIUrl":"https://doi.org/10.3724/SP.J.1206.2012.00210","url":null,"abstract":"","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":"36 1","pages":"698-702"},"PeriodicalIF":0.3,"publicationDate":"2012-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89493919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-09-03DOI: 10.3724/SP.J.1206.2012.00315
Jiang-Ning Zhou, Ya‐Jing Liu
{"title":"Circadian Rhythm of Melatonin and Alzheimer′s Disease*: Circadian Rhythm of Melatonin and Alzheimer′s Disease*","authors":"Jiang-Ning Zhou, Ya‐Jing Liu","doi":"10.3724/SP.J.1206.2012.00315","DOIUrl":"https://doi.org/10.3724/SP.J.1206.2012.00315","url":null,"abstract":"","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":"1969 1","pages":"796-803"},"PeriodicalIF":0.3,"publicationDate":"2012-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86586182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-09-03DOI: 10.3724/SP.J.1206.2012.00303
Juan Li, Jing Yu, Y. Niu
{"title":"Neuropsychological Impairment Characteristics of MCI and Its Early Detection and Intervention: Prevent and Delay The Onset of AD*: Neuropsychological Impairment Characteristics of MCI and Its Early Detection and Intervention: Prevent and Delay The Onset of AD*","authors":"Juan Li, Jing Yu, Y. Niu","doi":"10.3724/SP.J.1206.2012.00303","DOIUrl":"https://doi.org/10.3724/SP.J.1206.2012.00303","url":null,"abstract":"","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":"17 1","pages":"804-810"},"PeriodicalIF":0.3,"publicationDate":"2012-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81803037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-09-03DOI: 10.3724/SP.J.1206.2012.00217
Tan Wang, Xiulian Sun
{"title":"Molecular Regulaion of BACE1 and Its Function at The Early Onset of Alzheimer′s Disease: Molecular Regulaion of BACE1 and Its Function at The Early Onset of Alzheimer′s Disease","authors":"Tan Wang, Xiulian Sun","doi":"10.3724/SP.J.1206.2012.00217","DOIUrl":"https://doi.org/10.3724/SP.J.1206.2012.00217","url":null,"abstract":"","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":"37 1","pages":"709-714"},"PeriodicalIF":0.3,"publicationDate":"2012-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87502921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-08-06DOI: 10.3724/SP.J.1206.2012.00216
Dan QiongJie, YiTong Liu, Jia-Wei Wu, Zhi-Xin Wang, 王志新
{"title":"Crystallization of Mutations at SiteIII of Dvl2-DIX and Co-crystallization of Dvl2-DIX(G65A) With Ccd1-DIX*: Crystallization of Mutations at SiteIII of Dvl2-DIX and Co-crystallization of Dvl2-DIX(G65A) With Ccd1-DIX*","authors":"Dan QiongJie, YiTong Liu, Jia-Wei Wu, Zhi-Xin Wang, 王志新","doi":"10.3724/SP.J.1206.2012.00216","DOIUrl":"https://doi.org/10.3724/SP.J.1206.2012.00216","url":null,"abstract":"","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":"25 1","pages":"647-654"},"PeriodicalIF":0.3,"publicationDate":"2012-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90848040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-08-06DOI: 10.3724/SP.J.1206.2011.00308
D. Zhu, Kang-le Wang, Pei-Lin Chen, Ya-Qiong Jiang
{"title":"Effect of Oxymatrine on H 2 O 2 Resistance in L 6 Rat Myoblast Cells*: Effect of Oxymatrine on H 2 O 2 Resistance in L 6 Rat Myoblast Cells*","authors":"D. Zhu, Kang-le Wang, Pei-Lin Chen, Ya-Qiong Jiang","doi":"10.3724/SP.J.1206.2011.00308","DOIUrl":"https://doi.org/10.3724/SP.J.1206.2011.00308","url":null,"abstract":"","PeriodicalId":20655,"journal":{"name":"生物化学与生物物理进展","volume":"13 1","pages":"662-670"},"PeriodicalIF":0.3,"publicationDate":"2012-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82256430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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