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Treatment Preferences in Acute Psychosis: A Comparison of Patient and Staff Perspectives on Symptom Prioritization and Biopsychosocial Interventions. 急性精神病的治疗偏好:患者和医护人员对症状优先级和生物心理社会干预的观点比较。
IF 2.7 4区 医学 Q2 PSYCHIATRY Pub Date : 2025-03-01 Epub Date: 2024-10-29 DOI: 10.1007/s11126-024-10099-2
Rabea Fischer, Steffen Moritz, Jakob Scheunemann, Matthias Nagel, Charlotte Osthues, Daniel Schöttle, Daniel Luedecke

Patients with acute psychosis are often confronted with the prejudice that they refuse all treatment due to lack of insight. This study examined and compared the aims and preferences for treatment of patients with acute psychosis and of psychiatric inpatient staff. A total of 142 inpatients being treated for a psychotic disorder on either a locked or an open ward indicated which of a range of symptoms they want to be treated and which of various biopsychosocial treatment options they would like to receive. Staff members from the same wards reported which psychiatric symptoms they deemed relevant in the treatment of psychosis and which treatment options should be offered. Patients assigned the highest treatment need to neurocognitive symptoms, followed by affective and positive symptoms. In contrast, staff assigned the highest treatment need to positive symptoms, followed by neurocognitive and affective symptoms. Patients and staff on open wards expressed more treatment needs overall than did patients and staff on locked wards. Patients' desire for treatment differed across treatment types. In comparing patients on locked versus open wards, patients on open wards expressed higher approval of medication than patients on locked wards. Even patients with highly acute psychosis being treated on locked psychiatric wards endorsed treatment. Treatment preferences of this group deviated markedly in some instances from staffs' preferences. Considering their specific needs may contribute to increasing patient self-efficacy, and improving adherence to treatment.

急性精神病患者经常会面临一种偏见,认为他们因缺乏洞察力而拒绝一切治疗。这项研究考察并比较了急性精神病患者和精神科住院病人的治疗目的和偏好。共有 142 名在封闭病房或开放病房接受治疗的精神病住院患者表示,他们希望治疗一系列症状中的哪些症状,以及希望接受各种生物-心理-社会治疗方案中的哪些方案。同一病房的工作人员也报告了他们认为哪些精神病症状与治疗精神病相关,以及应该提供哪些治疗方案。患者认为神经认知症状最需要治疗,其次是情感症状和阳性症状。相比之下,工作人员认为阳性症状的治疗需求最大,其次是神经认知症状和情感症状。开放式病房的患者和工作人员比封闭式病房的患者和工作人员表达了更多的治疗需求。不同治疗类型的病人对治疗的渴望也不同。在比较上锁病房和开放式病房的病人时,开放式病房的病人比上锁病房的病人更认可药物治疗。即使是在上锁的精神病院接受治疗的高度急性精神病患者也认可治疗。在某些情况下,这部分患者的治疗偏好与工作人员的偏好存在明显偏差。考虑他们的特殊需求可能有助于提高患者的自我效能感,并改善治疗的依从性。
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引用次数: 0
Correction: Treatment Preferences in Acute Psychosis: A Comparison of Patient and Staff Perspectives on Symptom Prioritization and Biopsychosocial Interventions. 更正:急性精神病的治疗偏好:比较患者和工作人员对症状优先级和生物心理社会干预的看法。
IF 2.7 4区 医学 Q2 PSYCHIATRY Pub Date : 2025-03-01 DOI: 10.1007/s11126-024-10107-5
Rabea Fischer, Steffen Moritz, Jakob Scheunemann, Matthias Nagel, Charlotte Osthues, Daniel Schöttle, Daniel Luedecke
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引用次数: 0
The Mediating Role of Difficulties in Emotion Regulation and Earthquake Stress Coping in the Relationship Between Posttraumatic Cognitive Attribution and Posttraumatic Stress Disorder in Türkiye 2023 Earthquake Survivors. 情绪调节困难和地震应激应对在创伤后认知归因与创伤后应激障碍关系中的中介作用[j] [j][23]。
IF 2.7 4区 医学 Q2 PSYCHIATRY Pub Date : 2025-03-01 Epub Date: 2025-01-29 DOI: 10.1007/s11126-025-10118-w
Azmi Çağlar

Natural disasters such as earthquakes leave deep psychological effects on individuals that can lead to posttraumatic stress disorder, and understanding these effects is vital to support psychological recovery processes after trauma. In this context, the aim of this study was to examine the mediating role of emotion regulation difficulties, religious coping, positive reappraisal and seeking social support in the relationship between posttraumatic cognitive attributions and posttraumatic stress disorder in 2023 Kahramanmaraş Pazarcık, Elbistan and Hatay Yayladağı earthquake survivors (N = 408). The findings from the multiple mediation analysis showed the indirect effect of posttraumatic cognitive attribution on PTSD through difficulties in emotion regulation, religious coping, positive reappraisal, and seeking social support. Therefore, difficulties in emotion regulation may be a risk factor for PTSD, while religious coping, positive reappraisal and seeking social support may be protective factors. Strategies to reduce difficulties in emotion regulation and to improve religious coping, positive reappraisal and social support seeking in earthquake survivors may be necessary to reduce PTSD that may be caused by the earthquake.

自然灾害,如地震,会给个体留下深刻的心理影响,从而导致创伤后应激障碍,了解这些影响对于支持创伤后的心理恢复过程至关重要。在此背景下,本研究旨在探讨情绪调节困难、宗教应对、积极重评价和寻求社会支持在2023名kahramanmarakai Pazarcık、Elbistan和Hatay Yayladağı地震幸存者(N = 408)创伤后认知归因与创伤后应激障碍关系中的中介作用。多重中介分析结果表明,创伤后认知归因通过情绪调节困难、宗教应对困难、积极重评价困难和寻求社会支持等因素间接影响创伤后应激障碍。因此,情绪调节困难可能是PTSD的危险因素,而宗教应对、积极重评价和寻求社会支持可能是保护因素。减轻地震幸存者的情绪调节困难,提高他们的宗教应对、积极的再评价和社会支持寻求,可能是减少地震后应激障碍的必要策略。
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引用次数: 0
Psychometric Properties and Network Analysis of the Arabic Version of Reinforcement Sensitivity Theory of Personality Scale-Short Version in Patients with Anxiety Disorders. 焦虑障碍患者强化敏感性人格量表阿拉伯版-短版的心理测量特征及网络分析。
IF 2.7 4区 医学 Q2 PSYCHIATRY Pub Date : 2025-03-01 Epub Date: 2025-01-17 DOI: 10.1007/s11126-024-10109-3
Rasha Mohamed Abdelrahman, Abdulnaser Fakhrou, Mahmoud Ali Moussa, Mohaddeseh Roshan

This study aimed to examine the psychometric properties of the Arabic version of a short version of the Reinforcement Sensitivity Theory of Personality Questionnaire (RST-PQ-S) among a sample of 700 patients with anxiety disorders (53.1% were female). Participants completed the RST-PQ-S, NEO-FFI, Positive Mental Health (PMH), and Kessler Psychological Distress scale. Both Exploratory Factor Analysis (EFA) and Confirmatory Factor Analysis (CFA) were employed to test the construct validity of the scale. This study also utilized a network perspective, incorporating Exploratory Graph Analysis (EGA) and centrality measures. As a result of the EFA and CFA, it was determined that the scale consists of 22 items and six subdimensions. These subdimensions were named as follows: "Flight Fight-Freeze System", "Behavioral Inhibition System", "Reward Interest", "Reward Reactivity", "Goal-Drive Persistence", and "Impulsivity". Additionally, the network analysis's findings confirmed the six-factor structure derived from the construct validity assessment. The results of this study demonstrated that the Arabic version of the personality scale is a valid and reliable tool for assessing personality in Arabic-speaking individuals with anxiety disorders. It has the potential to serve as an important diagnostic instrument in clinical and research settings. These findings may assist psychologists and clinicians in Arabic-speaking countries to better understand how the personality traits and anxiety disorders are related.

本研究以700名焦虑障碍患者(53.1%为女性)为样本,考察了阿拉伯语版人格强化敏感性理论问卷(RST-PQ-S)的心理测量特征。参与者完成RST-PQ-S、NEO-FFI、积极心理健康(PMH)和Kessler心理困扰量表。采用探索性因子分析(EFA)和验证性因子分析(CFA)对量表的结构效度进行检验。本研究也利用网络视角,结合探索性图分析(EGA)和中心性测量。经综合评价和综合评价,确定该量表由22个项目和6个子维度组成。这些子维度分别为:“逃跑-战斗-冻结系统”、“行为抑制系统”、“奖励兴趣”、“奖励反应性”、“目标驱动持久性”和“冲动性”。此外,网络分析的结果证实了建构效度评估得出的六因子结构。本研究的结果表明,阿拉伯语版人格量表是评估阿拉伯语焦虑症患者人格的有效和可靠的工具。它有潜力作为临床和研究环境中的重要诊断工具。这些发现可能有助于阿拉伯语国家的心理学家和临床医生更好地理解人格特征和焦虑症之间的关系。
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引用次数: 0
Barriers to Treatment of Mental Disorders in Saudi Arabia. 沙特阿拉伯精神障碍治疗的障碍。
IF 2.7 4区 医学 Q2 PSYCHIATRY Pub Date : 2025-03-01 Epub Date: 2024-11-30 DOI: 10.1007/s11126-024-10104-8
Sumayah Aljhani, Sultan Aldughayim, Ziyad Alsweed, Sulaiman Alherbish, Faris Alhumaid, Rayan Alismail, Saleh Alkhalaf, Ibrahim AlBahouth

Mental disorders are a global health issue affecting millions of individuals. People with mental disorders often face barriers to treatment, including stigma and discrimination, social, religious, and familial barriers, and a lack of knowledge about available treatment options. These barriers can lead to delayed or untreated mental illnesses, with serious consequences for the individuals, their families, and communities. This cross-sectional study explores the treatment barriers for different mental disorders as they significantly impact people's lives. It includes patients diagnosed with mental disorders. The data were collected from the patients or their companions attending Qassim Mental Health Hospital's outpatient clinic. We used a self-administered online questionnaire, sociodemographic variables, and the barrier to access to care evaluation (BACE) scale. Our sample included 332 adult patients with mental disorders (men, 63.9%; women, 36.1%). The mean percentage scores for stigma-, attitude-, and instrument-related barriers were 26.7%, 33.0%, and 18.7%, respectively. Younger age was associated with higher scores in all three BACE domains. Patients with psychotic disorders faced stigma- and attitude-related barriers, but not instrument-related barriers. Patients with multiple mental conditions faced increased stigma- and instrument-related barriers but not attitude-related barriers. Further longitudinal studies are required to better understand these barriers to help patients with mental conditions.

精神障碍是影响数百万人的全球性健康问题。精神障碍患者往往面临治疗障碍,包括耻辱和歧视,社会、宗教和家庭障碍,以及缺乏对现有治疗方案的了解。这些障碍可能导致精神疾病的延迟或未经治疗,对个人、其家庭和社区造成严重后果。这项横断面研究探讨了不同精神障碍的治疗障碍,因为它们显著影响人们的生活。它包括被诊断患有精神障碍的患者。这些数据是从卡西姆精神健康医院门诊的病人或他们的同伴那里收集的。我们使用了一份自我管理的在线问卷、社会人口学变量和获得护理的障碍评估(BACE)量表。我们的样本包括332名成年精神障碍患者(男性,63.9%;女性,36.1%)。耻辱感、态度和工具相关障碍的平均百分比分别为26.7%、33.0%和18.7%。年龄越小,三个BACE域的得分越高。精神障碍患者面临与污名和态度相关的障碍,但没有与仪器相关的障碍。患有多种精神疾病的患者面临更多的耻辱感和与器械相关的障碍,而不是与态度相关的障碍。需要进一步的纵向研究来更好地了解这些障碍,以帮助患有精神疾病的患者。
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引用次数: 0
Prevalence and Changes in Usage of Mental Health Services for Rhode Island Children and Youth Before, During, and After Onset of the COVID-19 Pandemic. 在COVID-19大流行发生之前、期间和之后,罗德岛州儿童和青少年心理健康服务使用的患病率和变化
IF 2.7 4区 医学 Q2 PSYCHIATRY Pub Date : 2025-03-01 Epub Date: 2024-12-04 DOI: 10.1007/s11126-024-10103-9
Sharon Zanti, Chenyi Ma

This study reports the prevalence of inpatient, emergency department (ED), and outpatient mental health service usage of children/youth before, during, and after onset of the COVID-19 pandemic in Rhode Island. Additionally, we identify significant changes in usage across these time periods and the prevalence of each service type contingent upon various demographic profiles. This retrospective observational analysis used Rhode Island Medicaid claims to identify the unique children and youth who used inpatient, ED, and outpatient mental health services across three key time periods: pre-onset (March 2019-February 2020); onset (March 2020-February 2021); and post-onset (March 2021-February 2022). We used z-tests to analyze changes in the proportion of children/youth who accessed these services in each period. We examined relationships between demographic characteristics and time period with chi-square tests. Significant decreases in inpatient and ED usage were identified from pre-onset to onset (p < .05). While inpatient nearly returned to pre-pandemic usage in post-onset, ED usage remained lower. Outpatient usage increased significantly leading up to the pandemic but remained at similar levels between pre-onset and post-onset. From pre-onset to post-onset, females grew as a percentage of all inpatient, ED, and outpatient users. Over this same period, the proportion of inpatient users aged 12-18 increased and the proportion of ED and outpatient users aged 19-24 increased. Female usage of mental health services increased significantly, and older children/youth seemed to drive any significant increases. Future public health and disaster preparedness policies should focus on the unique mental health needs of these socially vulnerable groups.

本研究报告了罗德岛州儿童/青少年在COVID-19大流行之前、期间和之后的住院、急诊和门诊精神卫生服务使用率。此外,我们还确定了这些时间段内使用情况的重大变化,以及每种服务类型的流行程度取决于不同的人口统计概况。这项回顾性观察分析使用罗德岛州医疗补助计划的索赔来确定在三个关键时期使用住院、急诊科和门诊精神卫生服务的独特儿童和青少年:发病前(2019年3月- 2020年2月);发病时间(2020年3月- 2021年2月);发病后(2021年3月至2022年2月)。我们使用z检验来分析每个时期访问这些服务的儿童/青少年比例的变化。我们用卡方检验检验了人口统计学特征与时间段之间的关系。从发病前到发病期间,住院病人和急诊科的使用率显著下降(p
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引用次数: 0
Network Analysis of Internalizing and Externalizing Symptoms in Arab Gifted Children: A Cross-Sectional Study. 阿拉伯资优儿童内化和外化症状的网络分析:横断面研究
IF 2.7 4区 医学 Q2 PSYCHIATRY Pub Date : 2025-03-01 Epub Date: 2025-01-14 DOI: 10.1007/s11126-025-10112-2
Ayoub Hamdan Al-Rousan, Mohammad Nayef Ayasrah, Mohamad Ahmad Saleem Khasawneh

The current paper aimed to estimate the network structure of general psychopathology (internalizing and externalizing symptoms/disorders) among 239 gifted children in Jordan. This cross-sectional study with a convenience sampling method was conducted between September 2023 and October 2024 among gifted children aged 7-12. The Child Behavior Checklist (CBCL) was employed to assess six symptom clusters: conduct problems, attention-deficit/hyperactivity disorder (ADHD), and oppositional defiant problems as externalizing symptoms, and affective problems, anxiety issues, and somatic complaints as internalizing symptoms. We used the network analysis perspective by graphical least absolute shrinkage and selection operator (gLASSO) and the Extended Bayesian Information Criterion (EBIC). These methods were used to determine network structure and important nodes in the estimated network. "Sleeps less" (centrality strength = 2.04, edge weight = 0.33) was the central symptom in the affective cluster. In contrast, "worries" (centrality strength = 1.89, edge weight = 0.28) and "headaches" (centrality strength = 2.35, edge weight = 0.41) were pivotal in the anxiety and somatic clusters, respectively. The findings suggested that these symptoms had critical roles in the context of the general psychopathology among gifted children. Accordingly, the mentioned symptoms should be assessed and targeted among gifted children. Future studies could evaluate the results of targeting these symptoms on gifted children's well-being and daily functions.

本研究旨在评估约旦239名天才儿童一般精神病理(内化和外化症状/障碍)的网络结构。本研究于2023年9月至2024年10月对7-12岁的天才儿童进行了横断面研究。采用儿童行为检查表(CBCL)评估六个症状群:行为问题、注意缺陷/多动障碍(ADHD)和对立违抗性问题作为外化症状,情感问题、焦虑问题和躯体抱怨作为内化症状。我们通过图形最小绝对收缩和选择算子(gLASSO)和扩展贝叶斯信息准则(EBIC)使用网络分析视角。这些方法用于确定网络结构和估计网络中的重要节点。“睡眠不足”是情感类的中心症状(中心性强度= 2.04,边权= 0.33)。相反,“忧虑”(中心性强度= 1.89,边权= 0.28)和“头痛”(中心性强度= 2.35,边权= 0.41)分别在焦虑和躯体群集中起关键作用。研究结果表明,这些症状在天才儿童的一般精神病理中起着关键作用。因此,上述症状应在天才儿童中进行评估和针对性。未来的研究可以评估针对这些症状对天才儿童的健康和日常功能的影响。
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引用次数: 0
An Exploratory Study about Factors and Outcomes Associated with the Experience of Coercive Measures in Mental Health Settings. 精神卫生机构强制措施经历相关因素和结果的探索性研究。
IF 2.7 4区 医学 Q2 PSYCHIATRY Pub Date : 2025-03-01 Epub Date: 2025-01-16 DOI: 10.1007/s11126-024-10110-w
Jesús Herrera-Imbroda, Vera Carbonel-Aranda, Yaiza García-Illanes, Carlos Aguilera-Serrano, Antonio Bordallo-Aragón, Edgar García-Spínola, Daniel Torres-Campos, José María Villagrán, Juan Antonio García-Sanchez, Fermín Mayoral-Cleries, José Guzmán-Parra

Coercive measures are commonly used in mental health settings despite their negative effects. The subjective experience of coercion varies widely, and its short- and long-term health impacts are not well understood. This study aimed to analyze the association between different types of coercive measures experienced during psychiatric hospitalization, the subjective experience of coercion, and both short- and long-term health outcomes. The study included 111 patients from two mental health units who experienced coercive measures (mechanical restraint, involuntary medication, or both). Perceived coercion was assessed during hospitalization. Short-term outcomes (post-traumatic stress and treatment satisfaction) were evaluated before discharge, while long-term outcomes (functionality improvement, risk of readmission, and suicidal behavior) were assessed at five-year follow-up. Perceived coercion was associated with higher post-traumatic stress (p < 0.001) and lower satisfaction with treatment (p < 0.001) in the short term. In the long term, perceived coercion showed no association with functionality, readmission risk, or suicidal behavior. However, combined coercive measures were linked to lower functionality improvement (p = 0.028) and higher readmission risk (p = 0.028) compared to involuntary medication alone. The findings suggest that efforts to reduce negative subjective experiences associated with coercive measures may improve patient satisfaction and reduce trauma risk during hospitalization. Combined coercive measures may be a risk factor for poorer long-term outcomes and should be carefully considered.

尽管强制性措施有负面影响,但在精神卫生机构中普遍使用。对强迫的主观体验差别很大,其对健康的短期和长期影响也没有得到很好的了解。本研究旨在分析精神科住院期间不同类型胁迫措施、胁迫主观体验与短期和长期健康结果之间的关系。该研究包括来自两个精神卫生单位的111名患者,他们经历了强制措施(机械约束,非自愿用药,或两者兼而有之)。住院期间对感知到的胁迫进行了评估。出院前评估短期结果(创伤后应激和治疗满意度),而长期结果(功能改善、再入院风险和自杀行为)在5年随访中评估。感知到的强迫与较高的创伤后应激有关
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引用次数: 0
A Network Analysis of Depression and Cognitive Impairments in Fibromyalgia: A Secondary Analysis Study. 纤维肌痛中抑郁和认知障碍的网络分析:二次分析研究
IF 2.7 4区 医学 Q2 PSYCHIATRY Pub Date : 2025-03-01 Epub Date: 2024-11-26 DOI: 10.1007/s11126-024-10106-6
Dariush Tahmasebi Aghbelaghi, Mahbobeh Jalali, Natalie Tayim, Roghayeh Kiyani

Introduction: Fibromyalgia is a chronic condition often accompanied by cognitive impairments, such as difficulties with sustained attention, and emotional disturbances, particularly depression and anxiety. Understanding how these emotional and cognitive factors interact is crucial to improving treatment for fibromyalgia patients. This study aimed to investigate the network structure of these interactions, focusing on the relationship between depression, anxiety, and cognitive performance.

Method: A total of one hundred ten participants diagnosed with fibromyalgia completed self-reported assessments of depression and anxiety, alongside cognitive performance tests. Key measures included Continuous Performance Tasks (CPT) for impulsivity and sustained attention, the Stroop Interference Index (StI), Stroop Color Naming (StC), and Stroop Word Reading (StW). Network analysis was conducted to estimate the relationships between emotional and cognitive variables and assess their centrality within the network.

Results: Errors in CPT emerged as the most significant indicators of the relationship between depression and cognitive performance, with high centrality values observed for the Stroop tasks (StI, StC, and StW). Additionally, Trait Anxiety (A_T) and Beck Depression Inventory (BDI) measures showed high centrality, underscoring the critical role of emotional states in the network of cognitive and emotional variables. The centrality values for cognitive flexibility, processing speed, and inhibitory control were found to be 0.85, 0.78, and 0.72, respectively.

Conclusion: This study highlights the strong association between depression symptoms and deficits in cognitive domains, emphasizing the need for integrated care approaches that address both cognitive and emotional health. Multidisciplinary treatment programs, including cognitive rehabilitation and psychological support, could improve patient outcomes by targeting the most influential variables in the cognitive-emotional network.

引言纤维肌痛是一种慢性疾病,通常伴有认知障碍(如持续注意力困难)和情感障碍(尤其是抑郁和焦虑)。了解这些情绪和认知因素如何相互作用,对于改善纤维肌痛患者的治疗至关重要。本研究旨在调查这些相互作用的网络结构,重点研究抑郁、焦虑和认知表现之间的关系:共有 110 名被诊断为纤维肌痛的参与者完成了自我报告的抑郁和焦虑评估以及认知能力测试。主要测试包括冲动性和持续注意力的连续表现任务(CPT)、斯特罗普干扰指数(StI)、斯特罗普颜色命名(StC)和斯特罗普词语阅读(StW)。研究人员进行了网络分析,以估计情绪变量和认知变量之间的关系,并评估它们在网络中的中心地位:CPT中的错误是抑郁与认知表现之间关系最显著的指标,Stroop任务(StI、StC和StW)的中心性值较高。此外,特质焦虑(A_T)和贝克抑郁量表(BDI)也显示出较高的中心性,突出了情绪状态在认知和情绪变量网络中的关键作用。认知灵活性、处理速度和抑制控制的中心性值分别为 0.85、0.78 和 0.72:本研究强调了抑郁症状与认知领域缺陷之间的密切联系,强调了采取综合护理方法同时解决认知和情绪健康问题的必要性。包括认知康复和心理支持在内的多学科治疗方案可以通过针对认知-情感网络中最具影响力的变量来改善患者的预后。
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引用次数: 0
Are S100B and VILIP-1 Involved in a Common Mechanism of Neuroinflammation in Major Depressive Disorder? S100B 和 VILIP-1 是否参与了重度抑郁症神经炎症的共同机制?
IF 2.7 4区 医学 Q2 PSYCHIATRY Pub Date : 2025-03-01 Epub Date: 2024-11-08 DOI: 10.1007/s11126-024-10102-w
Nagihan Ayaz Naycı, Aybeniz Civan Kahve, Hasan Kaya, Andaç Uzdoğan, Yağmur Darben Azarsız, Süreyya Barun, Erol Göka

This study aimed to evaluate the role of neuroinflammation in neuronal and glial cells in the pathophysiology of Major Depressive Disorder (MDD) through different biomarkers.S100-B and VILIP-1 levels of patients diagnosed with MDD were evaluated before and after antidepressant treatment. A total of 65 patients diagnosed with MDD and 69 healthy controls were included. Serum levels of S100B and VILIP-1 were measured at the time of diagnosis and after eight weeks antidepressant treatment and compared with healthy controls. Hamilton Depression Rating Scale (HDRS) and the Clinical Global Impression Scale (CGI) were applied to assess the severity of depression. In our study, although serum S100B levels were higher in patients before treatment compared to healthy controls, this difference was not statistically significant. Regarding VILIP-1 levels, there was no statistically significant difference between patients and healthy controls. A positive and statistically significant correlation was found between S100B and VILIP-1 levels in MDD group before the treatment. At the eighth week of treatment, a statistically significant positive correlation was also found between S100B and VILIP-1 levels. Our research is the first study to evaluate MDD through two separate biomarkers specific to glial and neuronal cells.The fact that S100B and VILIP-1 levels showed significant correlations in patients diagnosed with MDD both before and after treatment suggests that they may play a shared role in the pathophysiology of the disorder. The correlation between S100B and VILIP-1 may serve as a guide in understanding the pathophysiology of the disorder and in identifying new drug development targets.

本研究旨在通过不同的生物标志物评估神经元和神经胶质细胞中的神经炎症在重度抑郁症(MDD)病理生理学中的作用。研究人员在抗抑郁治疗前后评估了确诊为MDD患者的S100-B和VILIP-1水平。研究共纳入了 65 名确诊为 MDD 的患者和 69 名健康对照者。在诊断时和八周抗抑郁治疗后测量血清中 S100B 和 VILIP-1 的水平,并与健康对照组进行比较。汉密尔顿抑郁量表(HDRS)和临床整体印象量表(CGI)用于评估抑郁症的严重程度。在我们的研究中,虽然与健康对照组相比,治疗前患者的血清 S100B 水平较高,但这一差异在统计学上并不显著。至于 VILIP-1 水平,患者与健康对照组之间的差异无统计学意义。MDD 组患者在治疗前的 S100B 和 VILIP-1 水平呈正相关,且在统计学上有显著意义。在治疗的第八周,S100B 和 VILIP-1 水平之间也发现了具有统计学意义的正相关。我们的研究是第一项通过神经胶质细胞和神经元细胞的两种不同生物标志物来评估 MDD 的研究。S100B 和 VILIP-1 水平在 MDD 患者治疗前后均显示出明显的相关性,这一事实表明它们可能在该疾病的病理生理学中发挥着共同的作用。S100B和VILIP-1之间的相关性可能有助于理解该疾病的病理生理学,并确定新的药物开发目标。
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Psychiatric Quarterly
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