A. Salehzadeh, Fatemeh Sayyad Delshadpour, Ataollah Sadat Shandiz
Accepted: 31 Jan, 2017 Abstract Background and Objectives: Breast cancer is one of the most common cancers in women around the world. Problems, such as treatment failure, drug resistance, heavy costs, other problems associated with the treatment of this type of cancer, have attracted the interest of many researchers to cyanobacteria, since these microorganisms have fewer side-effects compared to chemical drugs. In the present research, the effect of Oscillatoria extract was investigated on the viability of MCF7 cell line as well as caspase-9 gene expression.
{"title":"Cytotoxicity Effect and Changes in the Expression of Caspase-9 Gene in Breast Cancer Cell Line (MCF-7) Treated with the Extract of Oscillatoria Cyanobacteria","authors":"A. Salehzadeh, Fatemeh Sayyad Delshadpour, Ataollah Sadat Shandiz","doi":"10.29252/QUMS.12.1.26","DOIUrl":"https://doi.org/10.29252/QUMS.12.1.26","url":null,"abstract":"Accepted: 31 Jan, 2017 Abstract Background and Objectives: Breast cancer is one of the most common cancers in women around the world. Problems, such as treatment failure, drug resistance, heavy costs, other problems associated with the treatment of this type of cancer, have attracted the interest of many researchers to cyanobacteria, since these microorganisms have fewer side-effects compared to chemical drugs. In the present research, the effect of Oscillatoria extract was investigated on the viability of MCF7 cell line as well as caspase-9 gene expression.","PeriodicalId":20865,"journal":{"name":"Qom University of Medical Sciences Journal","volume":"292 1","pages":"26-34"},"PeriodicalIF":0.0,"publicationDate":"2018-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79494528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Accepted: 10 Jun, 2016 Abstract Background and Objectives: To protect the body from destructive effects of oxidants, living organisms have an antioxidant system (enzymatic and non-enzymatic). This system can be affected by many factors, including exercise training. The aim of the present research was to investigate the effect of 8 weeks of resistance training on gene expression of lymphocyte antioxidant enzymes and malondialdehyde (MDA) in healthy inactive men.
{"title":"The Effect of 8 Weeks of Resistance Training on Gene Expression Lymphocyte Antioxidant Enzymes and Malondialdehyde in Healthy Inactive Men","authors":"H. Amini, M. Azarbayjani, Kamal Azizbeigi Boukani","doi":"10.29252/QUMS.12.2.74","DOIUrl":"https://doi.org/10.29252/QUMS.12.2.74","url":null,"abstract":"Accepted: 10 Jun, 2016 Abstract Background and Objectives: To protect the body from destructive effects of oxidants, living organisms have an antioxidant system (enzymatic and non-enzymatic). This system can be affected by many factors, including exercise training. The aim of the present research was to investigate the effect of 8 weeks of resistance training on gene expression of lymphocyte antioxidant enzymes and malondialdehyde (MDA) in healthy inactive men.","PeriodicalId":20865,"journal":{"name":"Qom University of Medical Sciences Journal","volume":"46 1","pages":"74-83"},"PeriodicalIF":0.0,"publicationDate":"2018-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73765617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Rahmati, M. Ghanbarzadeh, Mohammad Hassan Aghaei
Accepted: 10 Jan, 2017 Abstract Background and Objectives: Studies have shown that impairment in kinases in the nervous system is related to many neurodegenerative disease. Glycogen synthase kinase-3β (GSK-3β) is a serine/threonine kinase that participates in regulation of various functions of neurons. Accordingly, GSK-3β is one of the drug targets for nervous system therapies. In this study, the effect of decreased activity in the form of neuropathic pain, was investigated on GSK-3β gene expression in sciatic nerve fiber of male Wistar rats.
{"title":"The Effect of Decreased Activity in the Form of Neuropathic Pain on GSK-3β Gene Expression in Sciatic Nerve Fiber of Male Wistar Rats","authors":"M. Rahmati, M. Ghanbarzadeh, Mohammad Hassan Aghaei","doi":"10.29252/QUMS.12.2.11","DOIUrl":"https://doi.org/10.29252/QUMS.12.2.11","url":null,"abstract":"Accepted: 10 Jan, 2017 Abstract Background and Objectives: Studies have shown that impairment in kinases in the nervous system is related to many neurodegenerative disease. Glycogen synthase kinase-3β (GSK-3β) is a serine/threonine kinase that participates in regulation of various functions of neurons. Accordingly, GSK-3β is one of the drug targets for nervous system therapies. In this study, the effect of decreased activity in the form of neuropathic pain, was investigated on GSK-3β gene expression in sciatic nerve fiber of male Wistar rats.","PeriodicalId":20865,"journal":{"name":"Qom University of Medical Sciences Journal","volume":"23 1","pages":"11-18"},"PeriodicalIF":0.0,"publicationDate":"2018-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90739720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Ebadollahi, F. Babaei, S. Zare, Maryam Ebadollahi
Accepted: 1 Jan, 2017 Abstract Background and Objectives: Parkinson is the most common degenerative disorder of central nervous system. Liver plays an important role in the metabolism of chemical drugs; synthesis of plasma proteins, and extensive use of levodopa in the treatment of Parkinson disease. This study aimed to find the effect of levodopa and hydroalcoholic extract of purslane on the concentration of liver enzymes.
{"title":"Evaluation of Antioxidant Properties of Hydroalcoholic Extract of Purslane (Portulaca oleracea) and Its Protective Effect on 6-Hydroxydopamine Induced Hepatic Damage in Parkinsonian Male Rats","authors":"S. Ebadollahi, F. Babaei, S. Zare, Maryam Ebadollahi","doi":"10.29252/QUMS.12.1.15","DOIUrl":"https://doi.org/10.29252/QUMS.12.1.15","url":null,"abstract":"Accepted: 1 Jan, 2017 Abstract Background and Objectives: Parkinson is the most common degenerative disorder of central nervous system. Liver plays an important role in the metabolism of chemical drugs; synthesis of plasma proteins, and extensive use of levodopa in the treatment of Parkinson disease. This study aimed to find the effect of levodopa and hydroalcoholic extract of purslane on the concentration of liver enzymes.","PeriodicalId":20865,"journal":{"name":"Qom University of Medical Sciences Journal","volume":"1 1","pages":"15-25"},"PeriodicalIF":0.0,"publicationDate":"2018-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83052610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Rahmani, H. K. Varkaneh, M. Yekaninejad, A. R. J. Motlagh
Accepted: 3 Jan, 2017 Abstract Background and Objectives: Today, the criteria of social acceptance and success, have changed, which affect psychological health, including self-esteem. On the other hand, obesity and overweight have increased in recent decades, which have many effects on the incidence of physical and psychological diseases. This study was carried out with the aim of investigating the relationship between obesity, waist circumference, and body fat with self-esteem in young men.
{"title":"The Relationship between Body Mass Index and Waist Circumference with Self-Esteem in Iranian Young Men","authors":"J. Rahmani, H. K. Varkaneh, M. Yekaninejad, A. R. J. Motlagh","doi":"10.29252/QUMS.12.1.80","DOIUrl":"https://doi.org/10.29252/QUMS.12.1.80","url":null,"abstract":"Accepted: 3 Jan, 2017 Abstract Background and Objectives: Today, the criteria of social acceptance and success, have changed, which affect psychological health, including self-esteem. On the other hand, obesity and overweight have increased in recent decades, which have many effects on the incidence of physical and psychological diseases. This study was carried out with the aim of investigating the relationship between obesity, waist circumference, and body fat with self-esteem in young men.","PeriodicalId":20865,"journal":{"name":"Qom University of Medical Sciences Journal","volume":"33 1","pages":"80-87"},"PeriodicalIF":0.0,"publicationDate":"2018-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77955370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Methods: In this experimental study, 32 male Wistar rats (weight, 230 ±20g), were divided into DMSO treated healthy group, DMSO treated gonadectomized group, or the extract’s solvent (0.5ml), and gonadectomized groups (received 50 and 100mg/kg hydroalcoholic extract of Cuminum cyminum L.) (n=8). First, the hydroalcoholic extract was extracted by soxhlet, then, the extract powder was prepared using an oven. Testicles were removed by surgery. All injections were intraperitoneal, and half an hour after the injection, anxiety test was carried out using elevated plus maze. Anxiety evaluation’s standard indicators (staying period and the number of entering to free arm), were assessed and recorded for 5 minutes. Data were analyzed using one-way analysis of variance and Tukey’s tests (p<0.05).
{"title":"The Effect of Hydroalcoholic Extract of Cuminum cyminum L. on Anxiety in Gonadectomized Male Rats","authors":"Z. Heshmat, N. Heydarieh, M. Khoshsokhan","doi":"10.29252/QUMS.12.1.35","DOIUrl":"https://doi.org/10.29252/QUMS.12.1.35","url":null,"abstract":"Methods: In this experimental study, 32 male Wistar rats (weight, 230 ±20g), were divided into DMSO treated healthy group, DMSO treated gonadectomized group, or the extract’s solvent (0.5ml), and gonadectomized groups (received 50 and 100mg/kg hydroalcoholic extract of Cuminum cyminum L.) (n=8). First, the hydroalcoholic extract was extracted by soxhlet, then, the extract powder was prepared using an oven. Testicles were removed by surgery. All injections were intraperitoneal, and half an hour after the injection, anxiety test was carried out using elevated plus maze. Anxiety evaluation’s standard indicators (staying period and the number of entering to free arm), were assessed and recorded for 5 minutes. Data were analyzed using one-way analysis of variance and Tukey’s tests (p<0.05).","PeriodicalId":20865,"journal":{"name":"Qom University of Medical Sciences Journal","volume":"3 1","pages":"35-43"},"PeriodicalIF":0.0,"publicationDate":"2018-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76217605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Methods: In this study, 36 trained females with iron deficiency anemia (mean age, 26.8±6.3 years and body mass index, 19.55±4.4kg/m 2 ) of Lahijan city, were selected as subjects and randomly divided into three groups of supplement+combined training, placebo+combined training, and control. Iron level and lipid profile were assessed before and after 8 weeks of combined training program and supplementation. Data were analyzed using paired t-test, one way analysis of variance, and Tukey post hoc test. The significance level was considered to be p<0.05.
{"title":"The Effect of Combined Exercise Training and Feroglobin Supplementation on Serum Iron and Lipid Profile in Women with Iron Deficiency Anemia","authors":"Sepideh Ghasemian, Zahra Hojjati Zidashti","doi":"10.29252/QUMS.12.2.84","DOIUrl":"https://doi.org/10.29252/QUMS.12.2.84","url":null,"abstract":"Methods: In this study, 36 trained females with iron deficiency anemia (mean age, 26.8±6.3 years and body mass index, 19.55±4.4kg/m 2 ) of Lahijan city, were selected as subjects and randomly divided into three groups of supplement+combined training, placebo+combined training, and control. Iron level and lipid profile were assessed before and after 8 weeks of combined training program and supplementation. Data were analyzed using paired t-test, one way analysis of variance, and Tukey post hoc test. The significance level was considered to be p<0.05.","PeriodicalId":20865,"journal":{"name":"Qom University of Medical Sciences Journal","volume":"42 1","pages":"84-93"},"PeriodicalIF":0.0,"publicationDate":"2018-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81253425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Accepted: 12 Jun, 2017 Abstract Background and Objectives: Salmonella enterica serovar Typhimurium is one of the most common Salmonella serotypes in gastroenteritis cases. ERIC-PCR method is used for genotyping studies and examinations in order to apply appropriate preventive and controlling conditions. This research was carried out with the objective of investigating the genotyping of Salmonella typhimurium strains in the treatment centers of Kerman province.
{"title":"Genotyping of Clinical Isolates of Salmonella enterica serovar Typhimurium from Medical Centers of Kerman Province Using ERIC-PCR Method","authors":"A. Moghadam, S. Nazarian","doi":"10.29252/QUMS.12.1.44","DOIUrl":"https://doi.org/10.29252/QUMS.12.1.44","url":null,"abstract":"Accepted: 12 Jun, 2017 Abstract Background and Objectives: Salmonella enterica serovar Typhimurium is one of the most common Salmonella serotypes in gastroenteritis cases. ERIC-PCR method is used for genotyping studies and examinations in order to apply appropriate preventive and controlling conditions. This research was carried out with the objective of investigating the genotyping of Salmonella typhimurium strains in the treatment centers of Kerman province.","PeriodicalId":20865,"journal":{"name":"Qom University of Medical Sciences Journal","volume":" 511","pages":"44-53"},"PeriodicalIF":0.0,"publicationDate":"2018-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91410131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Survey of Patients Satisfaction in the Faculty of Dentistry, Qom University of Medical Sciences in 2016-2017","authors":"S. Hajisadeghi, Z. Kashani","doi":"10.29252/QUMS.12.2.62","DOIUrl":"https://doi.org/10.29252/QUMS.12.2.62","url":null,"abstract":"","PeriodicalId":20865,"journal":{"name":"Qom University of Medical Sciences Journal","volume":"13 1","pages":"62-73"},"PeriodicalIF":0.0,"publicationDate":"2018-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81061937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Accepted: Abstract Background and Objectives: Multiple sclerosis is a chronic autoimmune disease with inflammation of the myelin sheath of the central nervous system. A series of factors, such as environmental factors and polymorphisms have been known to be associated with it. In this study, the correlation between polymorphism of rs2829803 in miR-155 and multiple sclerosis, was investigated in the patients referred to Farshchian Hospital of Hamadan City.
{"title":"An Association Study of rs2829803 Polymorphism in miRNA-155 with Multiple Sclerosis in Patients Referred to Farshchian Hospital of Hamadan City, (Iran)","authors":"Sanaz Abolfathirad, Soyar Sari, R. Mirfakhraie","doi":"10.29252/QUMS.12.2.28","DOIUrl":"https://doi.org/10.29252/QUMS.12.2.28","url":null,"abstract":"Accepted: Abstract Background and Objectives: Multiple sclerosis is a chronic autoimmune disease with inflammation of the myelin sheath of the central nervous system. A series of factors, such as environmental factors and polymorphisms have been known to be associated with it. In this study, the correlation between polymorphism of rs2829803 in miR-155 and multiple sclerosis, was investigated in the patients referred to Farshchian Hospital of Hamadan City.","PeriodicalId":20865,"journal":{"name":"Qom University of Medical Sciences Journal","volume":"34 1","pages":"28-34"},"PeriodicalIF":0.0,"publicationDate":"2018-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78930669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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