首页 > 最新文献

Qom University of Medical Sciences Journal最新文献

英文 中文
The Simultaneous Effect of Aerobic Exercise and Matricaria chamomilla L. Flower Extract on the Serum Level of Peptide C in Streptozotocin-Induced Diabetic Rats 有氧运动和洋甘菊提取物对链脲佐菌素诱导的糖尿病大鼠血清肽C水平的同时影响
Pub Date : 2019-12-10 DOI: 10.29252/qums.13.9.10
N. Mirazi, S. Bayat, A. H. pour, Z. Izadi
Methods: In this experimental study, 24 male Wistar rats (weight range, 200±20g), were randomly divided into 4 groups (n=6): control group (diabetic without treatment and training), MFE (diabetic treated with the extract), aerobic training (diabetic and training), and MFE+aerobic training (diabetic treated with extract+aerobic training). The aerobic training was performed as running on treadmill for 12 weeks (5 days per week, 60min/day, 26meter/min). The rats were diabetized with a single dose of streptozotocin (65mg/kg bw, ip). The MFE groups that daily received 200mg/kg orally (gavaged) along with exercise, were tested for 12 weeks. Data were analyzed using ShapiroWilk test, one way ANOVA, and Tukey post hoc test at the significant level of p<0.05.
方法:选取24只雄性Wistar大鼠(体重200±20g),随机分为4组(n=6):对照组(未治疗和训练的糖尿病)、MFE组(用提取物治疗的糖尿病)、有氧训练组(糖尿病和训练)、MFE+有氧训练组(用提取物治疗的糖尿病+有氧训练)。有氧训练在跑步机上进行,为期12周(每周5天,60分钟/天,26米/分钟)。用单剂量链脲佐菌素(65mg/kg bw, ip)诱导大鼠糖尿病。MFE组每日口服(灌胃)200mg/kg并运动,连续12周。资料分析采用ShapiroWilk检验、单因素方差分析和Tukey事后检验,p<0.05为显著水平。
{"title":"The Simultaneous Effect of Aerobic Exercise and Matricaria chamomilla L. Flower Extract on the Serum Level of Peptide C in Streptozotocin-Induced Diabetic Rats","authors":"N. Mirazi, S. Bayat, A. H. pour, Z. Izadi","doi":"10.29252/qums.13.9.10","DOIUrl":"https://doi.org/10.29252/qums.13.9.10","url":null,"abstract":"Methods: In this experimental study, 24 male Wistar rats (weight range, 200±20g), were randomly divided into 4 groups (n=6): control group (diabetic without treatment and training), MFE (diabetic treated with the extract), aerobic training (diabetic and training), and MFE+aerobic training (diabetic treated with extract+aerobic training). The aerobic training was performed as running on treadmill for 12 weeks (5 days per week, 60min/day, 26meter/min). The rats were diabetized with a single dose of streptozotocin (65mg/kg bw, ip). The MFE groups that daily received 200mg/kg orally (gavaged) along with exercise, were tested for 12 weeks. Data were analyzed using ShapiroWilk test, one way ANOVA, and Tukey post hoc test at the significant level of p<0.05.","PeriodicalId":20865,"journal":{"name":"Qom University of Medical Sciences Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81335345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Factors Influencing the Quality of Educational Performance of Faculty Members: A Qualitative Study 影响教师教育绩效质量的因素:一项质性研究
Pub Date : 2019-12-10 DOI: 10.29252/qums.13.10.34
S. N. Doulatabad, Mojgan Amireyanzadeh, R. Zarei, E. Ahmadi
Methods: This research qualitative is a descriptive exploratory study, which its data were collected through in-depth semi-structured interviews and analyzed based on thematic analysis. The statistical population of the study consisted of faculty members of Yasuj University of Medical Sciences, among whom, 18 were selected using purposive sampling. Initially, two general questions were asked about the educational performance for beginning the interview and then, the interview process was guided based on the participants' responses. The Interviews were performed in the participants' workplaces and each interview lasted between 1.5 and 2 hours on average. Interviews continued until achieving theoretical saturation.
方法:本研究定性为描述性探索性研究,通过深度半结构化访谈收集数据,并以专题分析为基础进行分析。统计人口的研究由教员Yasuj大学医学科学,其中18选择使用立意抽样。最初,面试开始时问了两个关于教育表现的一般性问题,然后,面试过程根据参与者的回答进行指导。访谈在参与者的工作场所进行,每次访谈平均持续1.5至2小时。访谈一直持续到理论饱和。
{"title":"Factors Influencing the Quality of Educational Performance of Faculty Members: A Qualitative Study","authors":"S. N. Doulatabad, Mojgan Amireyanzadeh, R. Zarei, E. Ahmadi","doi":"10.29252/qums.13.10.34","DOIUrl":"https://doi.org/10.29252/qums.13.10.34","url":null,"abstract":"Methods: This research qualitative is a descriptive exploratory study, which its data were collected through in-depth semi-structured interviews and analyzed based on thematic analysis. The statistical population of the study consisted of faculty members of Yasuj University of Medical Sciences, among whom, 18 were selected using purposive sampling. Initially, two general questions were asked about the educational performance for beginning the interview and then, the interview process was guided based on the participants' responses. The Interviews were performed in the participants' workplaces and each interview lasted between 1.5 and 2 hours on average. Interviews continued until achieving theoretical saturation.","PeriodicalId":20865,"journal":{"name":"Qom University of Medical Sciences Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79603117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Educational Needs Assessment of Faculty Members of Qom University of Medical Sciences, (Iran) 库姆医科大学教员教育需求评估(伊朗)
Pub Date : 2019-12-10 DOI: 10.29252/qums.13.9.69
F. Izadkhah, M. Ghaffari, S. Mohebi, Z. Gharlipour, Z. Ahmadi
Methods: This analytical descriptive cross-sectional study was carried on all faculty members of Qom University of Medical Sciences. Sampling method was census and 142 participants were included in the study. Data collection tools included demographic questionnaire and faculty members' educational needs assessment questionnaire with 6 domains that was completed by the faculty members. Data were analyzed using Pearson correlation coefficient, Independent t-test, and one way ANOVA.
方法:对库姆医科大学全体教职工进行分析性描述性横断面研究。抽样方法为人口普查,共纳入142人。数据收集工具包括人口统计问卷和教师教育需求评估问卷,共6个领域,由教师填写。数据分析采用Pearson相关系数、独立t检验和单因素方差分析。
{"title":"Educational Needs Assessment of Faculty Members of Qom University of Medical Sciences, (Iran)","authors":"F. Izadkhah, M. Ghaffari, S. Mohebi, Z. Gharlipour, Z. Ahmadi","doi":"10.29252/qums.13.9.69","DOIUrl":"https://doi.org/10.29252/qums.13.9.69","url":null,"abstract":"Methods: This analytical descriptive cross-sectional study was carried on all faculty members of Qom University of Medical Sciences. Sampling method was census and 142 participants were included in the study. Data collection tools included demographic questionnaire and faculty members' educational needs assessment questionnaire with 6 domains that was completed by the faculty members. Data were analyzed using Pearson correlation coefficient, Independent t-test, and one way ANOVA.","PeriodicalId":20865,"journal":{"name":"Qom University of Medical Sciences Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84681244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of the anti-bacterial efficacy of the silver incorporated resin composites 银树脂复合材料的抗菌效果评价
Pub Date : 2019-12-10 DOI: 10.29252/qums.13.10.1
M. Farahani, Abolfazl Farahani, Hasanali Shafiee, H. Farahani
Received: 9 Jul, 2019 Accepted: 26 Oct, 2019 Abstract Background and Objectives: Increased bacterial (streptococcal) biofilm aggregation on the surface of resin composite restorations in comparison with amalgam and glass ionomer restorations makes the composite restorations susceptible to secondary caries next to the restorations. In this study, the anti-Streptococcus mutans properties of resin composites containing silver nanoparticles were investigated.
摘要背景与目的:与汞合金和玻璃离子修复体相比,树脂复合修复体表面细菌(链球菌)生物膜聚集增加,使复合修复体容易发生邻近的继发性龋齿。在本研究中,研究了含银纳米粒子的树脂复合材料抗变形链球菌的性能。
{"title":"Assessment of the anti-bacterial efficacy of the silver incorporated resin composites","authors":"M. Farahani, Abolfazl Farahani, Hasanali Shafiee, H. Farahani","doi":"10.29252/qums.13.10.1","DOIUrl":"https://doi.org/10.29252/qums.13.10.1","url":null,"abstract":"Received: 9 Jul, 2019 Accepted: 26 Oct, 2019 Abstract Background and Objectives: Increased bacterial (streptococcal) biofilm aggregation on the surface of resin composite restorations in comparison with amalgam and glass ionomer restorations makes the composite restorations susceptible to secondary caries next to the restorations. In this study, the anti-Streptococcus mutans properties of resin composites containing silver nanoparticles were investigated.","PeriodicalId":20865,"journal":{"name":"Qom University of Medical Sciences Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78418858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Prevalence and Severity of Premenstrual Syndrome and Its Relationship with Psychological Well-Being in Students of Qom University of Medical Sciences, (Iran) 伊朗库姆医科大学学生经前期综合征患病率、严重程度及其与心理健康的关系
Pub Date : 2019-12-10 DOI: 10.29252/qums.13.10.72
Seyed Reza Seyedtabaee, P. Rahmatinejad, Kosar Feridooni
Received: 28 Sep, 2019 Accepted: 4 Jan, 2020 Abstract Background and Objectives: Premenstrual syndrome is defined as a group of physical and psychological symptom, which happens during luteal phase of the menstrual cycle. Researches have indicated that premenstrual syndrome has significant effects on mental health and well-being of women. The purpose of the present study was to investigate the prevalence and severity of premenstrual syndrome and its relationship with psychological well-being in the students of Qom University of Medical Sciences.
摘要背景与目的:经前综合征是指发生在月经周期黄体期的一组生理和心理症状。研究表明,经前综合症对女性的心理健康和幸福感有显著影响。本研究旨在探讨库姆医科大学学生经前综合征的患病率、严重程度及其与心理健康的关系。
{"title":"Prevalence and Severity of Premenstrual Syndrome and Its Relationship with Psychological Well-Being in Students of Qom University of Medical Sciences, (Iran)","authors":"Seyed Reza Seyedtabaee, P. Rahmatinejad, Kosar Feridooni","doi":"10.29252/qums.13.10.72","DOIUrl":"https://doi.org/10.29252/qums.13.10.72","url":null,"abstract":"Received: 28 Sep, 2019 Accepted: 4 Jan, 2020 Abstract Background and Objectives: Premenstrual syndrome is defined as a group of physical and psychological symptom, which happens during luteal phase of the menstrual cycle. Researches have indicated that premenstrual syndrome has significant effects on mental health and well-being of women. The purpose of the present study was to investigate the prevalence and severity of premenstrual syndrome and its relationship with psychological well-being in the students of Qom University of Medical Sciences.","PeriodicalId":20865,"journal":{"name":"Qom University of Medical Sciences Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76757418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Pyostomatitis Vegetant: An Important Diagnostic in Oral Diseases (Two Case Reports) 植物性化脓性口炎:口腔疾病的重要诊断(附两例报告)
Pub Date : 2019-12-10 DOI: 10.29252/qums.13.10.46
یاسمن صباغ زادگان, فاطمه اولیا, احسان بابایی زارچ
Received: 27 Apr, 2019 Accepted: 16 Nov, 2019 Abstract Background and Objectives: Inflammatory bowel disease (IBD) is a term that refers to crohn's disease (CD) and ulcerative colitis (UC). Oral manifestations in this disease category precedes the onset of gastrointestinal symptoms. In many patients, intestinal symptoms may be minimal or remain undiagnosed. In this paper, two cases of Pyostomatitis vegetans have been investigated.
摘要背景与目的:炎症性肠病(IBD)是克罗恩病(CD)和溃疡性结肠炎(UC)的总称。该疾病类别的口腔表现先于胃肠道症状的出现。在许多患者中,肠道症状可能很轻微或仍未被诊断。本文报告两例素食性脓口炎。
{"title":"Pyostomatitis Vegetant: An Important Diagnostic in Oral Diseases (Two Case Reports)","authors":"یاسمن صباغ زادگان, فاطمه اولیا, احسان بابایی زارچ","doi":"10.29252/qums.13.10.46","DOIUrl":"https://doi.org/10.29252/qums.13.10.46","url":null,"abstract":"Received: 27 Apr, 2019 Accepted: 16 Nov, 2019 Abstract Background and Objectives: Inflammatory bowel disease (IBD) is a term that refers to crohn's disease (CD) and ulcerative colitis (UC). Oral manifestations in this disease category precedes the onset of gastrointestinal symptoms. In many patients, intestinal symptoms may be minimal or remain undiagnosed. In this paper, two cases of Pyostomatitis vegetans have been investigated.","PeriodicalId":20865,"journal":{"name":"Qom University of Medical Sciences Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74366034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Designing a Health Management Process Model for Hospital Staff (Qualitative Research) 医院员工健康管理流程模型设计(定性研究)
Pub Date : 2019-12-10 DOI: 10.29252/qums.13.9.53
شهناز علیان عجم, علیرضا قاسمی زاد
Accepted: 28 Oct, 2019 Abstract Background and Objectives: Safety and health of employees is one of the top priorities of human resource managers in every organization. In the meantime, hospital staffs are exposed to various occupational hazards, including different types of infections, stressors, allergen materials, and so on. Therefore, the need for a health care and monitoring plan is one of the most important management programs. The present study was performed with the purpose of designing a staff health management process in hospitals.
摘要背景与目的:员工的安全和健康是每个组织的人力资源管理者的首要任务之一。与此同时,医院工作人员也面临着各种职业危害,包括不同类型的感染、压力源、过敏原物质等。因此,需要一个卫生保健和监测计划是最重要的管理方案之一。本研究旨在设计医院员工健康管理流程。
{"title":"Designing a Health Management Process Model for Hospital Staff (Qualitative Research)","authors":"شهناز علیان عجم, علیرضا قاسمی زاد","doi":"10.29252/qums.13.9.53","DOIUrl":"https://doi.org/10.29252/qums.13.9.53","url":null,"abstract":"Accepted: 28 Oct, 2019 Abstract Background and Objectives: Safety and health of employees is one of the top priorities of human resource managers in every organization. In the meantime, hospital staffs are exposed to various occupational hazards, including different types of infections, stressors, allergen materials, and so on. Therefore, the need for a health care and monitoring plan is one of the most important management programs. The present study was performed with the purpose of designing a staff health management process in hospitals.","PeriodicalId":20865,"journal":{"name":"Qom University of Medical Sciences Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73893171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of the Performance Indicators of the Emergency Department of Qom Shahid Beheshti Hospital before and after the Health Transformation Plan, (Iran) 库姆沙希德贝赫什蒂医院急诊部实施卫生转型计划前后绩效指标比较(伊朗)
Pub Date : 2019-12-10 DOI: 10.29252/qums.13.10.19
M. Zaheri, M. Zarei, Faeze Sadat Sate, S. Hashemi
* Corresponding Author: Mohammad Reza Zarei; Department of Emergency Medicine, Sina Trauma & Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran. Email: mrzarei@sina.tums.ac.ir Received: 11 March, 2019 Accepted: 5 Nov, 2019 Abstract Background and Objectives: Considering the initiation of the Health Transformation Plan in the Ministry of Health and Medical Education in 2014, evaluation of this plan is of particular importance. The aim of this study was to investigate the performance indicators of the Emergency Department of Shahid Beheshti Hospital in Qom city (before and after the transformation plan).
*通讯作者:Mohammad Reza Zarei;德黑兰医科大学新浪创伤外科研究中心急诊科,伊朗德黑兰。摘要背景与目的:考虑到2014年卫生部卫生转型计划的启动,对该计划的评估尤为重要。本研究的目的是调查库姆市Shahid Beheshti医院急诊科的绩效指标(改造计划前后)。
{"title":"Comparison of the Performance Indicators of the Emergency Department of Qom Shahid Beheshti Hospital before and after the Health Transformation Plan, (Iran)","authors":"M. Zaheri, M. Zarei, Faeze Sadat Sate, S. Hashemi","doi":"10.29252/qums.13.10.19","DOIUrl":"https://doi.org/10.29252/qums.13.10.19","url":null,"abstract":"* Corresponding Author: Mohammad Reza Zarei; Department of Emergency Medicine, Sina Trauma & Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran. Email: mrzarei@sina.tums.ac.ir Received: 11 March, 2019 Accepted: 5 Nov, 2019 Abstract Background and Objectives: Considering the initiation of the Health Transformation Plan in the Ministry of Health and Medical Education in 2014, evaluation of this plan is of particular importance. The aim of this study was to investigate the performance indicators of the Emergency Department of Shahid Beheshti Hospital in Qom city (before and after the transformation plan).","PeriodicalId":20865,"journal":{"name":"Qom University of Medical Sciences Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84720395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effect of Health Expenditure on Human Development Index (HDI) in Iran, 2001–2014 2001-2014年伊朗卫生支出对人类发展指数的影响
Pub Date : 2019-12-10 DOI: 10.29252/qums.13.10.26
M. Pakdaman, R. Askari, Sara Jam Barsang, M. Ranjbar, E. Ameli
Received: 28 Sep, 2019 Accepted: 1 Dec, 2019 Abstract Background and Objectives: The category of health is closely related to growth, comprehensive development, including economic development and human development. Health expenditure are important factors affecting economic growth. These expenditures can increase human development along with human resource and physical capital. The purpose of the present study was to determine the effect of health expenditures (public and private) on the Human Development Index (HDI).
摘要背景与目的:健康范畴与生长、全面发展密切相关,包括经济发展和人的发展。卫生支出是影响经济增长的重要因素。这些支出可以促进人力资源和物质资本的发展。本研究的目的是确定卫生支出(公共和私人)对人类发展指数(HDI)的影响。
{"title":"The Effect of Health Expenditure on Human Development Index (HDI) in Iran, 2001–2014","authors":"M. Pakdaman, R. Askari, Sara Jam Barsang, M. Ranjbar, E. Ameli","doi":"10.29252/qums.13.10.26","DOIUrl":"https://doi.org/10.29252/qums.13.10.26","url":null,"abstract":"Received: 28 Sep, 2019 Accepted: 1 Dec, 2019 Abstract Background and Objectives: The category of health is closely related to growth, comprehensive development, including economic development and human development. Health expenditure are important factors affecting economic growth. These expenditures can increase human development along with human resource and physical capital. The purpose of the present study was to determine the effect of health expenditures (public and private) on the Human Development Index (HDI).","PeriodicalId":20865,"journal":{"name":"Qom University of Medical Sciences Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88450854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Design and Production of Recombinant TAT Protein Structure, Catalytic Domain of Diphtheria Toxin, and Evaluation of Its Effect on Cell Line 重组TAT蛋白结构、白喉毒素催化结构域的设计与制备及其对细胞系的影响
Pub Date : 2019-12-01 DOI: 10.29252/qums.13.9.19
Mohaddeseh Parvand, Fahimeh Nemati Mansour, J. Amani
Received: 30 May, 2019 Accepted: 15 Oct, 2019 Abstract Background and Objectives: Cancer is one of the most deadly diseases in the present age and its conventional therapies have had low success. Toxin therapy of cancer is a new therapeutic approach, which has attracted the attention of pharmaceutical specialists. Diphtheria toxin consists of three functional, transducing, and binding domains, that the functional part inhibits protein synthesis and causes cell death. The purpose of this study was to produce the functional domain of the diphtheria toxin fused with a TAT penetrating peptide and to investigate its degree of lethality on cell line.
摘要背景与目的:癌症是当今时代最致命的疾病之一,其传统治疗方法成功率低。毒素治疗癌症是一种新的治疗方法,已引起药学专家的关注。白喉毒素由三个功能性、转导性和结合性结构域组成,其中功能性部分抑制蛋白质合成并导致细胞死亡。本研究的目的是产生与TAT穿透肽融合的白喉毒素的功能域,并研究其对细胞系的杀伤程度。
{"title":"Design and Production of Recombinant TAT Protein Structure, Catalytic Domain of Diphtheria Toxin, and Evaluation of Its Effect on Cell Line","authors":"Mohaddeseh Parvand, Fahimeh Nemati Mansour, J. Amani","doi":"10.29252/qums.13.9.19","DOIUrl":"https://doi.org/10.29252/qums.13.9.19","url":null,"abstract":"Received: 30 May, 2019 Accepted: 15 Oct, 2019 Abstract Background and Objectives: Cancer is one of the most deadly diseases in the present age and its conventional therapies have had low success. Toxin therapy of cancer is a new therapeutic approach, which has attracted the attention of pharmaceutical specialists. Diphtheria toxin consists of three functional, transducing, and binding domains, that the functional part inhibits protein synthesis and causes cell death. The purpose of this study was to produce the functional domain of the diphtheria toxin fused with a TAT penetrating peptide and to investigate its degree of lethality on cell line.","PeriodicalId":20865,"journal":{"name":"Qom University of Medical Sciences Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83286422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Qom University of Medical Sciences Journal
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1