Radiotherapy and Oncology最新文献

{"title":"Dosimetric advantages of adaptive IMPT vs. Enhanced workload and treatment time – A need for automation","authors":"Michelle Oud ,&nbsp;Sebastiaan Breedveld ,&nbsp;Marta Giżyńska ,&nbsp;Yi Hsuan Chen ,&nbsp;Steven Habraken ,&nbsp;Zoltán Perkó ,&nbsp;Ben Heijmen ,&nbsp;Mischa Hoogeman","doi":"10.1016/j.radonc.2024.110548","DOIUrl":"10.1016/j.radonc.2024.110548","url":null,"abstract":"<div><h3>Introduction</h3><div>In head-and-neck IMPT, trigger-based offline plan adaptation (Offline_{trigger-based}) is often used. Our goal was to compare this to four alternative adaptive strategies for dosimetry, workload and treatment time, considering also foreseen further technological advancements, including anticipated automation.</div></div><div><h3>Materials and methods</h3><div>Alternative strategies included weekly offline re-planning (Offline_weekly), daily plan selection from a library (Library_static and Library_progsressive) and a fast, approximate daily online re-optimization approach (Online_re-opt). Impact on CTV coverage and NTCPs was assessed by simulations based on repeat-CTs from 15 patients. Full daily re-planning was used as dosimetric benchmark. Increases in workload and treatment time were estimated.</div></div><div><h3>Results</h3><div>Both for coverage and NTCPs, fast Online_re-opt performed as well as full re-planning. Compared to current practice, Online<strong>_re</strong>_-opt showed enhanced probabilities for high coverage, and resulted in reductions in grade ≥ II NTCPs of 4.6 ± 1.7 %-point for xerostomia and 4.2 ± 2.3 %-point for dysphagia. Offline_weekly and library strategies did not show coverage enhancements and resulted in smaller NTCP improvements. Further automation can largely limit workload and treatment time increases. With anticipated further automation, adaptation-related workload of Offline_weekly, Library_static, Library_progressive, and Online_re-opt was expected to increase by 3, 8, 21, and 66 h for 35 fraction treatment courses compared to Offline_{trigger-based}. The corresponding adaptation-related prolonged treatment times were estimated to be 0, 4, 6, and 29 min/fraction.</div></div><div><h3>Conclusion</h3><div>Online adaptive strategies could approach dosimetric quality of full re-planning at the cost of additional workload and prolonged treatment time compared to the current offline adaptive strategy. Automation needs to play a key role in making more complex adaptive approaches feasible.</div></div>","PeriodicalId":21041,"journal":{"name":"Radiotherapy and Oncology","volume":"201 ","pages":"Article 110548"},"PeriodicalIF":4.9,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142352810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of dopamine receptor antagonists and radiation on mouse neural stem/progenitor cells","authors":"Ling He ,&nbsp;Kruttika Bhat ,&nbsp;Angeliki Ioannidis ,&nbsp;Frank Pajonk","doi":"10.1016/j.radonc.2024.110562","DOIUrl":"10.1016/j.radonc.2024.110562","url":null,"abstract":"<div><h3>Background</h3><div>Dopamine receptor antagonists have recently been identified as potential anti-cancer agents in combination with radiation, and a first drug of this class is in clinical trials against pediatric glioma. Radiotherapy causes cognitive impairment primarily by eliminating neural stem/progenitor cells and subsequent loss of neurogenesis, along with inducing inflammation, vascular damage, and synaptic alterations. Here, we tested the combined effects of dopamine receptor antagonists and radiation on neural stem/progenitor cells.</div></div><div><h3>Methods</h3><div>Using transgenic mice that report the presence of neural stem/progenitor cells through Nestin promoter-driven expression of EGFP, the effects of dopamine receptor antagonists alone or in combination with radiation on neural stem/progenitor cells were assessed in sphere-formation assays, extreme limiting dilution assays, flow cytometry and real-time PCR <em>in vitro</em> and <em>in vivo</em> in both sexes.</div></div><div><h3>Results</h3><div>We report that hydroxyzine and trifluoperazine exhibited sex-dependent effects on murine newborn neural stem/progenitor cells <em>in vitro</em>. In contrast, amisulpride, nemonapride, and quetiapine, when combined with radiation, significantly increased the number of neural stem/progenitor cells in both sexes. <em>In vivo</em>, trifluoperazine showed sex-dependent effects on adult neural stem/progenitor cells, while amisulpride demonstrated significant effects in both sexes. Further, amisulpride increased sphere forming capacity and stem cell frequency in both sexes when compared to controls.</div></div><div><h3>Conclusion</h3><div>We conclude that a therapeutic window for dopamine receptor antagonists in combination with radiation potentially exists, making it a novel combination therapy against glioblastoma. Normal tissue toxicity following this treatment scheme likely differs depending on age and sex and should be taken into consideration when designing clinical trials.</div></div>","PeriodicalId":21041,"journal":{"name":"Radiotherapy and Oncology","volume":"201 ","pages":"Article 110562"},"PeriodicalIF":4.9,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142352820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aims+Scope/Editorial Board/ Publication information","authors":"","doi":"10.1016/S0167-8140(24)03530-8","DOIUrl":"10.1016/S0167-8140(24)03530-8","url":null,"abstract":"","PeriodicalId":21041,"journal":{"name":"Radiotherapy and Oncology","volume":"200 ","pages":"Article 110552"},"PeriodicalIF":4.9,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142323197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The EORTC 22922/10925 trial investigating regional nodal irradiation in stage I-III breast cancer: Outcomes according to locoregional and systemic therapies","authors":"Orit Kaidar-Person ,&nbsp;Liesbeth J. Boersma ,&nbsp;Peter De Brouwer ,&nbsp;Caroline Weltens ,&nbsp;Carine Kirkove ,&nbsp;Karine Peignaux-Casasnovas ,&nbsp;Volker Budach ,&nbsp;Femke van der Leij ,&nbsp;Max Peters ,&nbsp;Nicola Weidner ,&nbsp;Sofia Rivera ,&nbsp;Geertjan van Tienhoven ,&nbsp;Alain Fourquet ,&nbsp;Georges Noel ,&nbsp;Mariacarla Valli ,&nbsp;Matthias Guckenberger ,&nbsp;Eveline Koiter ,&nbsp;Severine Racadot ,&nbsp;Roxolyana Abdah-Bortnyak ,&nbsp;Harry Bartelink ,&nbsp;Philip M. Poortmans","doi":"10.1016/j.radonc.2024.110563","DOIUrl":"10.1016/j.radonc.2024.110563","url":null,"abstract":"<div><div>The EORTC 22922/10925 trial aimed to investigate the impact on overall survival (OS) of elective internal mammary and medial supraclavicular (IM-MS) radiation therapy (RT) in breast cancer stage I–III. Surgery for the primary tumour and axillary lymph nodes, chest wall RT, boost RT after whole breast RT in breast conserving therapy (BCT), RT to operated axilla, and systemic therapy were per physician’s preference. The aim of the current analysis is to assess breast cancer outcomes according to different locoregional and systemic therapy used in the trial.</div></div><div><h3>Material/Methods</h3><div>Data with a median follow-up of 15.7 years were extracted from the trial’s case report forms. Kaplan-Meier curves of disease-free and OS and cumulative incidence curves of breast cancer events were produced. An exploratory analysis of the effect of the type of locoregional and systemic therapy on breast cancer outcomes was conducted using the Cox model or the Fine &amp; Gray model accounting for competing risks, both models being adjusted for baseline patient and disease characteristics and treatment. The significance level was set at 5 %, 2-sided.</div></div><div><h3>Results</h3><div>Of the 4,004 patients included, 625 (16%) did not receive any postoperative systemic therapy, 1,185 (30%) received endocrine therapy only, 994 (25%) chemotherapy only, and 1,200 (30%) both chemotherapy and endocrine therapy, without differences between the randomisation arms.</div><div>Administration and type of therapy was associated with age, menopausal status, clinical T- and N-stage and ER status (p &lt; 0.0001). Local control was better with mastectomy (with/without postmastectomy RT) as compared to BCT, but mastectomy was associated with more distant metastasis (DM) as <em>first</em> event. Similarly, DM as <em>first</em> event occurred more in the BCT group that received a boost as compared to no boost and in those who received RT to the lower axillary level. IM-MS RT reduced significantly regional recurrences and improved disease-free survival in a sensitivity stratified analysis. OS was worse with mastectomy as compared to BCT and with irradiation of the axilla but better with sentinel node dissection and adjuvant combined chemo and hormonal therapy.</div></div><div><h3>Conclusion</h3><div>Different components of therapy influenced the site of <em>first</em> event. IM-MS RT improved outcomes in different breast cancer outcomes were most probably related that the group were balanced due to the trial arms and stratification methods.</div></div>","PeriodicalId":21041,"journal":{"name":"Radiotherapy and Oncology","volume":"201 ","pages":"Article 110563"},"PeriodicalIF":4.9,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142352823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of new-onset atrial fibrillation in patients with non-small cell lung cancer treated with curative-intent conventional radiotherapy","authors":"Fariba Tohidinezhad ,&nbsp;Leonard Nürnberg ,&nbsp;Femke Vaassen ,&nbsp;Rachel MA ter Bekke ,&nbsp;Hugo JWL Aerts ,&nbsp;Lizza El Hendriks ,&nbsp;Andre Dekker ,&nbsp;Dirk De Ruysscher ,&nbsp;Alberto Traverso","doi":"10.1016/j.radonc.2024.110544","DOIUrl":"10.1016/j.radonc.2024.110544","url":null,"abstract":"<div><h3>Background</h3><div>Atrial fibrillation (AF) is an important side effect of thoracic Radiotherapy (RT), which may impair quality of life and survival. This study aimed to develop a prediction model for new-onset AF in patients with Non-Small Cell Lung Cancer (NSCLC) receiving RT alone or as a part of their multi-modal treatment.</div></div><div><h3>Patients and Methods</h3><div>Patients with stage I-IV NSCLC treated with curative-intent conventional photon RT were included. The baseline electrocardiogram (ECG) was compared with follow-up ECGs to identify the occurrence of new-onset AF. A wide range of potential clinical predictors and dose-volume measures on the whole heart and six automatically contoured cardiac substructures, including chambers and conduction nodes, were considered for statistical modeling. Internal validation with optimism-correction was performed. A nomogram was made.</div></div><div><h3>Results</h3><div>374 patients (mean age 69 ± 10 years, 57 % male) were included. At baseline, 9.1 % of patients had AF, and 42 (11.2 %) patients developed new-onset AF. The following parameters were predictive: older age (OR=1.04, 95 % CI: 1.013–1.068), being overweight or obese (OR=1.791, 95 % CI: 1.139–2.816), alcohol use (OR=4.052, 95 % CI: 2.445–6.715), history of cardiac procedures (OR=2.329, 95 % CI: 1.287–4.215), tumor located in the upper lobe (OR=2.571, 95 % CI: 1.518–4.355), higher forced expiratory volume in 1 s (OR=0.989, 95 % CI: 0.979–0.999), higher creatinine (OR=1.008, 95 % CI: 1.002–1.014), concurrent chemotherapy (OR=3.266, 95 % CI: 1.757 to 6.07) and left atrium D_max (OR=1.022, 95 % CI: 1.012–1.032). The model showed good discrimination (area under the curve = 0.80, 95 % CI: 0.76–0.84), calibration and positive net benefits.</div></div><div><h3>Conclusion</h3><div>This prediction model employs readily available predictors to identify patients at high risk of new-onset AF who could potentially benefit from active screening and timely management of post-RT AF.</div></div>","PeriodicalId":21041,"journal":{"name":"Radiotherapy and Oncology","volume":"201 ","pages":"Article 110544"},"PeriodicalIF":4.9,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142327999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility, safety and outcomes of stereotactic radiotherapy for ultra-central thoracic oligometastatic disease guided by linear endobronchial ultrasound-inserted fiducials","authors":"Calvin Sidhu ,&nbsp;Colin Tang ,&nbsp;Alison Scott ,&nbsp;Hema Yamini Ramamurty ,&nbsp;Lokesh Yagnik ,&nbsp;Sue Morey ,&nbsp;Martin Phillips ,&nbsp;Angela Jacques ,&nbsp;Rajesh Thomas","doi":"10.1016/j.radonc.2024.110547","DOIUrl":"10.1016/j.radonc.2024.110547","url":null,"abstract":"<div><h3>Background &amp; purpose</h3><div>Local treatment of oligometastases has been found to improve survival and prognosis. Stereotactic body radiotherapy (SBRT) has emerged as a treatment option for oligometastases but its use in ultra-central (UC) areas can cause significant toxicity and mortality. Fiducial markers (FM) can be used to improve SBRT accuracy, and can be inserted in the central thorax using linear endobronchial ultrasound (EBUS) bronchoscopy. Outcomes of FM-guided SBRT for UC thoracic oligometastases is unknown.</div></div><div><h3>Methods</h3><div>A single-centre retrospective study investigating the feasibility, safety and outcomes of both linear EBUS-inserted FMs and subsequent FM-guided SBRT for UC-oligometastatic disease. Motion analyses of FMs were also performed.</div></div><div><h3>Results</h3><div>Thirty outpatients underwent 32 EBUS-FM insertion procedures with 100 % success, and no major procedural mortality or morbidity. Minor complications were 4.8 % incidence of delayed FM-displacement. UC FM-guided SBRT was completed in 20 patients with 99.9 % fractions delivered. Median SBRT dose delivered was 40 Gy over a median of 8 fractions. Majority of adverse events were Grade 1 and there was no SBRT-related mortality. Local control with SBRT was 95 %, with overall survival at 1-year and 3-years of 90 % and 56.3 % respectively. Median overall survival after SBRT was 43.6 months. FM movements in UC areas were recorded being greatest in the superior-inferior axis.</div></div><div><h3>Conclusion</h3><div>Combined linear EBUS sampling and FM-insertion in UC thoracic oligometastatic disease is feasible and safe. UC-SBRT to oligometastases using FM guidance was found to have minimal complications and associated with moderate survival up to 3 years post-treatment.</div></div>","PeriodicalId":21041,"journal":{"name":"Radiotherapy and Oncology","volume":"201 ","pages":"Article 110547"},"PeriodicalIF":4.9,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142352821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is full-automation in radiotherapy treatment planning ready for take off?","authors":"Dylan Callens ,&nbsp;Ciaran Malone ,&nbsp;Antony Carver ,&nbsp;Christian Fiandra ,&nbsp;Mark J. Gooding ,&nbsp;Stine S. Korreman ,&nbsp;Joana Matos Dias ,&nbsp;Richard A. Popple ,&nbsp;Humberto Rocha ,&nbsp;Wouter Crijns ,&nbsp;Carlos E. Cardenas","doi":"10.1016/j.radonc.2024.110546","DOIUrl":"10.1016/j.radonc.2024.110546","url":null,"abstract":"<div><div>Radiotherapy treatment planning is undergoing a transformation with the increasing integration of automation. This transition draws parallels with the aviation industry, which has a long-standing history of addressing challenges and opportunities introduced by automated systems. Both fields witness a shift from manual operations to systems capable of operating independently, raising questions about the risks and evolving role of humans within automated workflows. In response to this shift, a working group assembled during the ESTRO Physics Workshop 2023, reflected on parallels to draw lessons for radiotherapy. A taxonomy is proposed, leveraging insights from aviation, that outlines the observed levels of automation within the context of radiotherapy and their corresponding implications for human involvement. Among the common identified risks associated with automation integration are complacency, overreliance, attention tunneling, data overload, a lack of transparency and training. These risks require mitigation strategies. Such strategies include ensuring role complementarity, introducing checklists and safety requirements for human-automation interaction and using automation for cognitive unload and workflow management. Focusing on already automated processes, such as dose calculation and auto-contouring as examples, we have translated lessons learned from aviation. It remains crucial to strike a balance between automation and human involvement. While automation offers the potential for increased efficiency and accuracy, it must be complemented by human oversight, expertise, and critical decision-making. The irreplaceable value of human judgment remains, particularly in complex clinical situations. Learning from aviation, we identify a need for human factors engineering research in radiation oncology and a continued requirement for proactive incident learning.</div></div>","PeriodicalId":21041,"journal":{"name":"Radiotherapy and Oncology","volume":"201 ","pages":"Article 110546"},"PeriodicalIF":4.9,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142352822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Five-year results of the very accelerated partial breast irradiation VAPBI phase I-II GEC-ESTRO trial","authors":"Jose Luis Guinot ,&nbsp;Cristina Gutierrez-Miguelez ,&nbsp;Norbert Meszaros ,&nbsp;Victor Gonzalez-Perez ,&nbsp;Miguel Angel Santos ,&nbsp;Dina Najjari ,&nbsp;Andrea Slocker ,&nbsp;Tibor Major ,&nbsp;Csaba Polgar","doi":"10.1016/j.radonc.2024.110543","DOIUrl":"10.1016/j.radonc.2024.110543","url":null,"abstract":"<div><h3>Background and purpose</h3><div>The standard partial breast postoperative treatment for early breast carcinomas with multi-catheter interstitial brachytherapy (MIBT) requires 7–8 fractions in 4–5 days as used in the APBI GEC-ESTRO phase III trial. In 2017 the GEC-ESTRO Breast Cancer Working Group started a Phase I-II trial to study if very accelerated partial breast irradiation (VAPBI) using 3–4 fractions could be equivalent.</div></div><div><h3>Material</h3><div>81 patients with low-risk invasive carcinomas underwent high dose rate MIBT. Mean age was 68 (51–90); 33 women received 4 fractions of 6.25 Gy in 2–3 days, and 48 subsequent patients 3 fractions of 7.45 Gy in 2 days, 36 perioperatively and 45 postoperatively.</div></div><div><h3>Results</h3><div>Median follow-up was 62 months, with 5-year actuarial breast recurrence of 3.4 % (two cases). One patient died due to metastasis. Pigmentation changes in the entrance of tubes remained visible only in 12.3 % in long term (skin G1 toxicity). Fibrosis or slight induration (G1) in 22.2 % and G2 in 9.9 %. No case of telangiectasia has been described. Cosmetic outcome is good or excellent in 95 % and fair in 5 %. Four tumors located in the retroareolar area showed nipple retraction.</div></div><div><h3>Conclusion</h3><div>VAPBI with MIBT using four fractions of 6.25 Gy or three fractions of 7.45 Gy in two or three days offers good local control, with a 5-year rate of fibrosis G2 similar to the GEC ESTRO phase III trial. VAPBI in two days is a good choice to decrease the total time of treatment, which is beneficial for the patient and reduces the workload.</div></div>","PeriodicalId":21041,"journal":{"name":"Radiotherapy and Oncology","volume":"201 ","pages":"Article 110543"},"PeriodicalIF":4.9,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142322911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantifying and visualising uncertainty in deep learning-based segmentation for radiation therapy treatment planning: What do radiation oncologists and therapists want?","authors":"M. Huet-Dastarac ,&nbsp;N.M.C. van Acht ,&nbsp;F.C. Maruccio ,&nbsp;J.E. van Aalst ,&nbsp;J.C.J. van Oorschodt ,&nbsp;F. Cnossen ,&nbsp;T.M. Janssen ,&nbsp;C.L. Brouwer ,&nbsp;A. Barragan Montero ,&nbsp;C.W. Hurkmans","doi":"10.1016/j.radonc.2024.110545","DOIUrl":"10.1016/j.radonc.2024.110545","url":null,"abstract":"<div><h3>Background and purpose</h3><div>During the ESTRO 2023 physics workshop on “AI for the fully automated radiotherapy treatment chain”, the topic of deep learning (DL) segmentation was discussed. Despite its widespread use in radiotherapy, the time needed to evaluate and correct DL segmentations remains burdensome. While segmentation uncertainty could be beneficial for clinicians, there is a lack of understanding on what information should be presented to ease their task. This study aimed to gather insights from clinicians on uncertainty visualisation options.</div></div><div><h3>Materials and methods</h3><div>Two sessions of structured interviews were conducted across four institutions already using DL segmentation clinically. The first session focused on the main problems hindering the clinical use of DL. In the second session, ten visualisation options displaying uncertainty information at different levels (structure, slice, or voxel) with binary or continuous values were presented. Dosimetric information was also present in some visualisations. For each case, sixteen clinicians (radiation oncologists and radiation therapists) were asked to grade an overall score, the usability, the training required, and the expected time gain.</div></div><div><h3>Results</h3><div>Participants preferred the binary voxel-level uncertainty visualisation, followed by binary structure-level uncertainty visualisation. Combining structure-level and voxel-level visualisation methods has been proposed as a promising approach. The benefits of dosimetric information were perceived diversely among participants since it complexifies the display but could be useful for the online adaptive workflow.</div></div><div><h3>Conclusion</h3><div>Preferences for uncertainty visualisation methods were assessed within a multi-institutional experienced group of clinicians. Further refinement of preferences may help in selecting the best options for clinical implementation.</div></div>","PeriodicalId":21041,"journal":{"name":"Radiotherapy and Oncology","volume":"201 ","pages":"Article 110545"},"PeriodicalIF":4.9,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142328000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on Bentsen et al.'s study of rib fracture risk after stereotactic body radiotherapy.","authors":"Ahmet Oguz Tugcu, Galip Dogukan Dogru, Cemal Ugur Dursun","doi":"10.1016/j.radonc.2024.110536","DOIUrl":"10.1016/j.radonc.2024.110536","url":null,"abstract":"","PeriodicalId":21041,"journal":{"name":"Radiotherapy and Oncology","volume":" ","pages":"110536"},"PeriodicalIF":4.9,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142294141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}