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Seroprevalence and Epidemiological studies of bovine viral diarrhea in cattle in New Valley Province, Egypt. 埃及新谷省牛病毒性腹泻血清流行病学研究。
Pub Date : 2023-08-01 DOI: 10.21608/nvvj.2023.212013.1020
A. Sayed, Yasser F. Elnaker, Osama Ali
: Bovine viral diarrhea (BVD) is one of the most imperative worldwide diseases in ruminants leading to substantial damage as well as extensive economic losses for the cattle industry. To our knowledge, there have been no reports about the disease’s situation in New Valley province, so the goal of this study was to estimate the level of bovine viral diarrhea virus (BVDV) infection in cattle herds through serodiagnosis and determining factors influencing the course of infection (current epidemiological situation) which will aid in establishment of control strategy. In this study a total of 1400 cattle of di ff erent ages, sexes and breeds (not previously vaccinated with BVD vaccines) were screened clinically for symptoms of BVD infection. 260 cattle out of totally 1400 screened cattle (18.6%) showing clinical signs arousing suspicion of BVD (49 cattle (18.8%) exhibit respiratory manifestation, 63 (24.2%) cattle su ff ered from diarrhea, 37 (14.2%) with mixed enteric and respiratory signs , 43 (16.5%) with retarded growth, oral lesion was detected in only 6 cattle (2.3%) , While the congenital anomalies were recorded in 18 (6.9%) , abortion occurred in 29 female cattle (11.1%) and only 15 cattle ( 5.8%) su ff ered from infertility trouble ) . Totally 260 clinically diseased cattle undergo Serum Neutralization Test (SNT) for detection of BVDV infection. The results revealed that 83 cattle out of 260 (31.9%) were detected as seropositive (positive for BVDV antibodies), showed clinical signs of BVD infection represented in 17 cattle showed respiratory manifestation (nasal discharge), 22 cattle su ff ered from diarrhea, 12 with mixed enteric and respiratory signs , 6 with retarded growth, oral lesion was detected in Only 2 cattle , While the congenital anomalies were recorded in 5 , abortion occurred in 15 female cattle and only 4 cattle su ff ered from Infertility trouble According to age, the seroprevalence of BVDV for antibodies was higher in in cattle aged ( > 6M to 2 year) (37.50%) and the lowest rate was (21.73%) in cattle aged (1day: 2month). Rendering to sex and breed, female cattle (37.80%) had a greater infection rate than male (21.87%) and infection was higher in Frisian bread (34.05%) than native bread (29.50%). Concerning to season, the highest prevalence of infection was (40.24%) in Winter and the lowest rate was (16.66%) in Autumn. Regarding to locality, the highest prevalence of infection was (45.45%) in EL-Farfara, and the lowest rate was (31%) in Balat. This prevalence of BVDV in cattle of new valley province, Egypt reveals the necessity of further studying BVDV infection in the area
牛病毒性腹泻(BVD)是世界范围内最严重的反刍动物疾病之一,对养牛业造成重大损害和广泛的经济损失。据我们所知,目前还没有关于新谷省牛病毒性腹泻病毒(BVDV)的报道,因此本研究的目的是通过血清诊断和确定感染过程的影响因素(流行病学现状)来估计牛群中牛病毒性腹泻病毒(BVDV)的感染水平,以帮助制定控制策略。在这项研究中,共有1400头不同年龄、性别和品种的牛(以前未接种过BVD疫苗)进行了BVD感染症状的临床筛查。在1400头牛中,有260头牛(18.6%)表现出疑似BVD的临床症状,其中呼吸症状49头(18.8%),腹泻63头(24.2%),肠道和呼吸混合症状37头(14.2%),生长迟缓43头(16.5%),口腔病变6头(2.3%),先天性异常18头(6.9%)。发生流产的母牛29头(11.1%),发生不孕的母牛15头(5.8%)。采用血清中和试验(SNT)对260头临床病牛进行BVDV感染检测。结果发现,260头牛中血清阳性83头(31.9%),BVD感染临床症状17头(鼻分泌物),腹泻22头,肠道和呼吸混合症状12头,生长迟缓6头,口腔病变仅2头,先天异常5头。按年龄分,BVDV抗体血清阳性率在6 ~ 2岁牛中最高(37.50%),在1日龄和2个月龄牛中最低(21.73%)。按性别和品种划分,母牛(37.80%)感染率高于公牛(21.87%),弗里斯兰面包(34.05%)感染率高于本地面包(29.50%)。季节上,冬季感染率最高(40.24%),秋季感染率最低(16.66%);从地区来看,EL-Farfara感染率最高(45.45%),Balat感染率最低(31%)。埃及新谷省牛中BVDV的流行表明有必要进一步研究该地区BVDV感染情况
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引用次数: 0
Clinical Study On the Impact of Amino Acids, Multi-Minerals, and Vitamins Combination Against Small Ruminants With Anemia In New Valley Governorate 氨基酸、多种矿物质和维生素组合对新谷省小反刍动物贫血影响的临床研究
Pub Date : 2023-08-01 DOI: 10.21608/nvvj.2023.215591.1022
S. Galbat, Yasser F. Elnaker, N. Ibrahim, Marwa El-Zeftawy
: Anemia syndrome is defined as a reduction in erythrocyte mass, hematocrit, and hemoglobin (Hb) concentration and sometimes leads to tissue hypoxia. Domesticated sheep and goats are essential to food security and the national economy. The present study aimed to determine the clinical impact of anemia in sheep and goats from di ff erent localities in the New Valley governorate. 150 sheep and 360 goats were clinically examined. Blood and fecal samples were collected from multiple locations. Hematological variables, serum iron (Fe + 2 ), copper (Cu + 2 ), and vitamin B 12 concentrations were estimated. Moreover, blood film and fecal examination were analyzed. Furthermore, the e ff ect of amino acids, multi-minerals, and vitamins combination (AMVC) administration was studied on clinically anemic sheep and goats. The results revealed significant improvement in Hb, red blood cells count, mean corpuscular volume, and mean corpuscular Hb in anemic sheep and goats administrated AMVC compared to anemic ones. Moreover, serum Fe + 2 , Cu + 2 , and vitamin B 12 levels were elevated. The current research found that anemic syndrome had significant detrimental e ff ects on the health of sheep and goats in the New Valley governorate; however, using multivitamins, minerals, and essential amino acids in the ration can restore these e ff ects.
贫血综合征的定义是红细胞质量、红细胞压积和血红蛋白(Hb)浓度降低,有时导致组织缺氧。驯养的绵羊和山羊对粮食安全和国民经济至关重要。本研究旨在确定贫血对新谷省不同地区绵羊和山羊的临床影响。临床检查绵羊150只,山羊360只。从多个地点采集了血液和粪便样本。血液变量、血清铁(Fe + 2)、铜(Cu + 2)和维生素b12浓度进行了评估。并对血膜及粪便检查进行分析。此外,还研究了氨基酸、多种矿物质和维生素组合(AMVC)对临床贫血绵羊和山羊的影响。结果显示,与贫血绵羊和山羊相比,给予AMVC的贫血绵羊和山羊的Hb、红细胞计数、平均红细胞体积和平均红细胞Hb显著改善。血清Fe + 2、Cu + 2和维生素b12水平升高。目前的研究发现,贫血综合症对新山谷省的绵羊和山羊的健康有显著的有害影响;然而,在日粮中使用多种维生素、矿物质和必需氨基酸可以恢复这些效果。
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引用次数: 0
Supplementing Levocarnitine and Thymosin V To improve Growth and Immunity in Broiler Chickens 饲粮中添加左卡尼汀和胸腺素V促进肉仔鸡生长和免疫
Pub Date : 2023-08-01 DOI: 10.21608/nvvj.2023.215420.1021
M. Soliman, M. Abdelhafez
: Objective: This study aimed to investigate the e ff ects of supplementing broiler chickens’ drinking water with levocarnitine and thymosin V on their growth, immunological condition, and performance. Methods: One hundred one-day-old non-vaccinated cobb broiler chicks were randomly divided into four groups. The control group received no treatment, Group 2 received levocarnitine-infused water, Group 3 received thymosin V-infused water, and Group 4 received both levocarnitine and thymosin V-infused water. Body weight, feed intake, lymphoid organ weight, hematological parameters, phagocytic activity, and interleukin 2 (IL-2) levels were measured and compared among the groups. Results: Levocarnitine supplementation resulted in increased body weight gain and feed intake. Thymosin V supplementation led to enhanced lymphoid organ weight and improved hematological parameters. All treated groups showed higher phagocytic activity and phagocytic index values compared to the control group. IL-2 levels were significantly increased in the treated groups. Conclusion: The supplementation of levocarnitine and thymosin V in broiler chickens’ drinking water positively influenced growth performance and immune function. Levocarnitine improved body weight gain and nutrient utilization, while thymosin V enhanced immune-related parameters. These findings suggest that levocarnitine and thymosin V have potential as dietary supplements to enhance broiler chicken production and immune response. Further research is needed to optimize their usage and understand the underlying mechanisms.
目的:研究在肉鸡饮水中添加左卡尼汀和胸腺素V对肉鸡生长、免疫状况和生产性能的影响。方法:100只1日龄未接种疫苗的科布肉仔鸡随机分为4组。对照组不给予治疗,组2给予左卡尼汀输注水,组3给予胸腺素v输注水,组4同时给予左卡尼汀和胸腺素v输注水。测定各组体重、采食量、淋巴器官重量、血液学参数、吞噬活性和白细胞介素2 (IL-2)水平,并进行比较。结果:左卡尼汀的添加增加了猪的体重和采食量。补充胸腺酶V可增加淋巴器官重量和改善血液学参数。各处理组的吞噬活性和吞噬指数均高于对照组。治疗组IL-2水平显著升高。结论:在肉鸡饮水中添加左卡尼汀和胸腺素V对肉鸡生长性能和免疫功能有积极影响。左卡尼汀改善体重增加和营养利用,而胸腺素V增强免疫相关参数。这些结果表明,左卡尼汀和胸腺酶V有可能作为饲粮补充剂提高肉鸡产量和免疫反应。需要进一步的研究来优化它们的使用并了解其潜在机制。
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引用次数: 0
Evaluation Of Some Locally Fermented Milk Products In New Valley Governorate 新谷省一些地方发酵乳制品的评价
Pub Date : 2023-01-01 DOI: 10.21608/nvvj.2023.158263.1011
Reem Eid, E. Mohamed, Rania Ewida
One hundred and forty random samples of yoghurt and Laban raib, seventy of each, were collected from different localities and villages in El-Kharga city, New Valley Governorate, Egypt, for chemical and bacteriologic examination. The obtained results of yoghurt samples showed that the average values of acidity%, total coliforms and fecal coliform , S. Aureus , yeasts, and molds were 1.13, 6.8×10 4 , 5.5×10 4 , 1.42×10 4 , 7.2×107 and 4.9×10 6 CFU/ml, respectively. On the other hand, in Laban raib samples, they were 1.13, 1.6×10 5 , 1.1×10 5 , 2.4×10 3 , 2.1×107 and 2.8×10 5 CFU/ml, respectively. The prevalence of E. coli and anaerobic bacteria in yoghurt samples was 11.4 and 2.8 %, while in Laban raib samples was 8.5 and 4.3%. Enterococci couldn’t be detected in all examined yoghurt and Laban raib samples. The aim of this research was to investigate the chemical and bacteriological characteristics of locally produced yoghurt and Laban raib in El-Kharga city, New Valley governorate, Egypt. Based on the results, both yoghurt and Laban raib samples showed high levels of total coliforms , fecal coliforms , and molds. Additionally, the prevalence of E. coli was relatively high in both types of samples, which may indicate poor hygiene practices during production or handling. However, the absence of Enterococci in all examined samples is a positive finding. These results suggest the need for improved hygiene and quality control measures in the production of these dairy products in the region. In conclusion, this study highlights the importance of monitoring the quality of locally produced dairy products and implementing appropriate measures to ensure their safety and hygiene
从埃及新谷省El-Kharga市的不同地点和村庄随机收集了140份酸奶和拉班莱布样品,各70份,用于化学和细菌学检查。酸奶样品的酸度%、总大肠菌群和粪便大肠菌群、金黄色葡萄球菌、酵母和霉菌的平均值分别为1.13、6.8×10 4、5.5×10 4、1.42×10 4、7.2×107和4.9×10 6 CFU/ml。另一方面,在拉班拉布样品中,它们分别为1.13、1.6×10 5、1.1×10 5、2.4×10 3、2.1×107和2.8×10 5 CFU/ml。酸奶样品中大肠杆菌和厌氧菌的患病率分别为11.4%和2.8%,拉班茶样品中大肠杆菌和厌氧菌的患病率分别为8.5%和4.3%。在所有检测的酸奶和拉班拉布样品中均未检出肠球菌。本研究的目的是调查埃及新谷省El-Kharga市当地生产的酸奶和Laban raib的化学和细菌学特性。根据结果,酸奶和拉班莱布样品都显示出高水平的总大肠菌群、粪便大肠菌群和霉菌。此外,这两类样品中大肠杆菌的流行率相对较高,这可能表明生产或处理过程中的卫生习惯不佳。然而,在所有检查的样本中都没有肠球菌,这是一个积极的发现。这些结果表明,有必要改善该地区这些乳制品生产中的卫生和质量控制措施。总之,这项研究强调了监测当地生产的乳制品质量和采取适当措施确保其安全和卫生的重要性
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引用次数: 0
Stress Dampening Effect of Common Salt on Oreochromis Niloticus During Transport 普通盐对尼罗褐虾运输过程中的应激抑制作用
Pub Date : 2023-01-01 DOI: 10.21608/nvvj.2023.202116.1018
Heba Hana, M. Abd El-Galil, M. Mousa, Rasha Abd El-Lateif, A. Osman, Arafa Emam
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引用次数: 0
Effect of the underground water on health state and growth rate of Nile Tilapia fish (Oreochromis niloticus) in the New Valley Governorate. 新河谷省地下水对尼罗罗非鱼健康状况和生长速度的影响
Pub Date : 2023-01-01 DOI: 10.21608/nvvj.2023.179535.1014
S. Sotohy, Rasha M. Hassan, Ayman Abd-Elmaguid, Mahmoud Arafaa, Mahmoud Mohamed
Twenty water samples were collected from El-Dakhlah City in the New valley governorate, five from fishpond. Metal analyses were carried out in Animal Health Research Institute, Dokki, Giza, Egypt. A total of 200 unsexed 8 months Tilapia fish were used in this study. Fifty fish were collected randomly from each pond and then weighed. The results of this study showed that lead, cadmium, and iron were higher than permissible limits of WHO, on the other hand Iodine, copper and zinc were lower than permissible limits of WHO. Manganese was higher than permissible limits mostly in all examined ponds . The concentration of heavy metals and trace elements in fish tissue showed that Lead, cadmium, iron, zinc, copper, and iodine were lower than permissible limits while Manganese was higher than permissible limits. The average body weight gain of Tilapia fish was high in the filtered water ponds than other ponds.
从新谷省的El-Dakhlah市收集了20个水样,从鱼塘收集了5个水样。金属分析在埃及吉萨Dokki动物卫生研究所进行。本研究选用了200尾8月龄非性别罗非鱼。从每个池塘随机收集50条鱼,然后称重。研究结果显示,铅、镉、铁均高于世界卫生组织的允许限量,碘、铜、锌均低于世界卫生组织的允许限量。在所有被检查的池塘中,锰含量大多高于允许限量。鱼类组织中重金属和微量元素的浓度显示,铅、镉、铁、锌、铜、碘低于允许值,锰高于允许值。过滤池罗非鱼的平均增重高于其他池。
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引用次数: 0
Influence of different sources of groundwater on broiler performance in New Valley governorate. 新谷省不同地下水来源对肉鸡生产性能的影响
Pub Date : 2023-01-01 DOI: 10.21608/nvvj.2023.171760.1013
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引用次数: 0
Evaluation of the efficacy of vaccine in coccidiosis in broilers in New Valley governorate 新谷省肉鸡球虫病疫苗效果评价
Pub Date : 2023-01-01 DOI: 10.21608/nvvj.2023.183405.1015
Wafaa Mahmoud, Esraa Mahmoud, M. Soliman, M. A. E. Abd El Hafez
Avian coccidiosis is the primary parasitic disease that afflicts poultry and is responsible for significant economic losses. Vaccination has emerged as a viable alternative to chemical treatments for controlling broiler coccidiosis and has shown considerable potential for mitigating its impact. This study aimed to evaluate the effectiveness of Fortegra ® vaccination in controlling coccidiosis in broiler chickens. A total of 245 unsexed one-day-old broiler chickens obtained from Masr poultry were divided into seven groups, with 35 birds in each group. Four groups (GA1, GA2, GA3, and GA4) were vaccinated with Fortegra ® while three groups (GB1, GB2, and GB3) served as non-vaccinated controls. At 6 days of age, all chicks in the vaccinated group were administered Fortegra ® , while all groups except GA3 and GB3 were infected with coccidia at day 22. The results showed that vaccination did not prevent infection but resulted in lower lesion scores compared to the conventional and control groups. Body weight in the vaccinated group (GA) was lower than that of the non-vaccinated (GB) groups. Microscopic examination of fecal samples collected at different ages confirmed coccidia infection in all experimental groups. Broiler intestinal mucosa scrapings revealed typical forms of Eimeria species, leading to bloody diarrhea and petechial hemorrhage. After a 72-hour period at 30ºC with forced aeration, sporulation occurred, and oocysts were stored in a potassium dichromate solution. Microscopic examination confirmed the presence and shape of oocysts, and experimental samples displayed a 500 bp amplicon size specific to Eimeria spp. While Fortegra ® vaccination did not prevent infection, it resulted in lower lesion scores compared to the conventional and control groups. Thus, vaccination may serve as an effective approach for controlling coccidiosis in broiler chickens, but further research is necessary to optimize vaccination protocols and evaluate its long-term effects on broiler production.
禽球虫病是影响家禽的主要寄生虫病,造成重大经济损失。疫苗接种已成为控制肉鸡球虫病的一种可行的替代化学治疗方法,并显示出相当大的减轻其影响的潜力。本研究旨在评价Fortegra®疫苗接种对肉鸡球虫病的控制效果。选取Masr家禽1日龄无性别肉鸡245只,随机分为7组,每组35只。四组(GA1, GA2, GA3和GA4)接种Fortegra®,三组(GB1, GB2和GB3)作为未接种疫苗的对照组。6日龄时,接种组所有雏鸡均接种Fortegra®,22日龄时除GA3和GB3组外其余各组均感染球虫。结果显示,与常规组和对照组相比,接种疫苗不能预防感染,但导致较低的病变评分。接种组(GA)的体重低于未接种组(GB)。不同年龄收集的粪便镜检均证实实验组有球虫感染。肉仔鸡肠黏膜刮痕显示典型的艾美耳球虫种类,导致血性腹泻和点状出血。在30℃下强制通风72小时后,产孢发生,卵囊保存在重铬酸钾溶液中。显微镜检查证实了卵囊的存在和形状,实验样本显示艾美耳球虫特有的500 bp扩增子大小。虽然Fortegra疫苗接种不能预防感染,但与常规组和对照组相比,它导致的病变评分较低。因此,疫苗接种可能是控制肉鸡球虫病的有效方法,但需要进一步研究以优化疫苗接种方案并评估其对肉鸡生产的长期影响。
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引用次数: 0
Clinical and Laboratory Studies on Emaciation and Ill-thriftiness in Cattle in New Valley Governorate 新谷省牛的消瘦和不节俭的临床和实验室研究
Pub Date : 2022-11-11 DOI: 10.21608/nvvj.2022.268688
S. Galbat, Yasser F. Elnaker, Rabab El-Zoghby, E. Mohamed
Cattle have an economic importance in New Valley governorate. Emaciation and poor production of cattle were the main complains of farmers. The aim of the present work is to identify the real causes of ill-thriftiness in cattle in New-Valley Governorate And evaluate the relation between emaciation and clinical sign, the hematological, biochemical parameters in blood serum of cattle and parasitology for fecal sample of emaciated cattle. This study was conducted for a period from July 2021 to June 2022. A total number of 200 cattle of different ages, sexes, and breeds from different localities in new valley governorate; EI-Karga, EL-Dakhla and Balat, classified into two groups first one includes 170 emaciated cattle and second group include (30) cattle is consider as healthy cattle (control). My study carried out on body condition score (1, 2). Clinical examination showed decrease in body weight, not increase in BW, dehydration, pale conjunctival mucous membranes (signs of anemia), infertility, reduced milk production, pica, and heavy infestation by tick. The results of hematological analysis showed that significant decrease of RBC and Hb concentration in BCS1 and BCS2, Additionally, HCT and ESINO showed significant increase in BCS1 While the results of biochemical serum analysis explained that significant decrease of serum Ca 2+ , P 3+ , Cu 2+ , Fe 2++ and Gl in BCS1. On the other hand, there was significant decrease of serum P 3+ , Cu2+, Fe 2++ , and Gl concentrations were decreased in BCS2 when compared to control. The activity of liver enzymes was noted there was significant decrease of AST activity in BCS1and BCS2. While serum creatinine was significant decrease in BCS1 when compared toBCS2 and control. The results of fecal examination showed that the highest prevalence of infection was infected by protozoa, followed by infected by nematode and the lowest rate was infected by trematode. The results of the present study indicate that ill-thriftiness in cattle occur because of bad management, nutritional deficiency, and failure to use anthelmintic regularly in periodic system for eliminate both external and internal parasites, Also the nature of the soil, water, and climate in the New Valley Governorate. Identification of the risk factors associated with ill-thrift may provide useful information, which assist to construct the suitable preventive measures.
牛在新谷省具有重要的经济意义。牛的消瘦和产量差是农民的主要抱怨。本研究的目的是找出新谷省牛节俭不良的真正原因,并评价其与临床症状、牛血清血液学、生化指标和牛粪便寄生虫学的关系。这项研究的进行时间为2021年7月至2022年6月。来自新谷省不同地区的200头不同年龄、性别和品种的牛;EI-Karga, EL-Dakhla和Balat分为两组,第一组包括170头瘦弱牛,第二组包括(30头)被认为是健康牛(对照)。我的研究是根据身体状况评分进行的(1,2)。临床检查显示体重下降,体重没有增加,脱水,结膜粘膜苍白(贫血的迹象),不孕症,产乳减少,异食癖和严重的蜱虫感染。血液学分析结果显示BCS1和BCS2红细胞和Hb浓度显著降低,HCT和ESINO显示BCS1浓度显著升高,血清生化分析结果显示BCS1血清ca2 +、p3 +、cu2 +、fe2 +和Gl浓度显著降低。另一方面,与对照组相比,BCS2组血清p3 +、Cu2+、fe2 ++和Gl浓度显著降低。肝酶活性观察到bcs1和BCS2的AST活性显著降低。而BCS1组血清肌酐与bcs2组和对照组相比显著降低。粪便检查结果显示,原虫感染率最高,线虫感染率次之,吸虫感染率最低。本研究结果表明,牛的不节俭是由于管理不善、营养缺乏和没有定期使用驱虫药来清除内外寄生虫,以及新河谷省土壤、水和气候的性质。查明与不节约有关的危险因素可提供有用的资料,有助于制订适当的预防措施。
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引用次数: 0
N-Acetyl cysteine alleviates carbon-tetrachloride induced acute liver injury in rats n-乙酰半胱氨酸减轻四氯化碳所致大鼠急性肝损伤
Pub Date : 2022-08-11 DOI: 10.21608/nvvj.2022.152184.1007
Hasnaa Mansour, Marwa El-Zeftawy, M. Aboubakr, Rabab R Elzoghby
The liver is a vital organ that performs most of the body's metabolic and detoxifying functions. There are various exogenous and endogenous factors that might cause liver issues. Carbon tetrachloride (CCL 4 ) is non-inflammable colorless organic compound and employed in a variety of industrial fields. N-acetylcysteine (NAC) is one of the prospective pharmaceutical candidates possesses multiple clinical applications. The purpose of this study is to determine whether NAC has a protective effect in cases of liver injury or not. Thirty male albino rats were involved in the study, which lasted one month. They were categorized into three groups: control, liver injury group (0.5 ml/kg rat body weight (Bwt) CCL 4 administered orally twice a week), and protective group (150 mg/kg Bwt NAC supplied orally). Serum lipid and protein profiles and liver enzymes activities were evaluated. Antioxidant, oxidative stress, and anti-inflammatory parameters were also assessed. Additionally, hepatic tissue was subjected to a histopathological investigation. The biochemical and histopathological results revealed dramatic improvement of studied parameters in NAC protective group comparing to liver injury one. Hence, we can conclude that, NAC shown a great potential in attenuating liver injury induced by CCL 4 via refinement tumor necrosis factor-alpha, interleukin-6 and reduced glutathione pathway.
肝脏是一个重要的器官,执行身体的大部分代谢和排毒功能。有各种外源性和内源性因素可能导致肝脏问题。四氯化碳(ccl4)是一种不燃的无色有机化合物,广泛应用于各种工业领域。n -乙酰半胱氨酸(NAC)是具有多种临床应用前景的候选药物之一。本研究的目的是确定NAC是否对肝损伤有保护作用。30只雄性白化大鼠参与了这项持续一个月的研究。肝损伤组(每周2次口服0.5 ml/kg大鼠体重(Bwt) ccl4)和肝保护组(150mg /kg Bwt口服NAC)。评估血清脂质、蛋白谱和肝酶活性。抗氧化、氧化应激和抗炎参数也进行了评估。此外,对肝组织进行组织病理学检查。生化和组织病理学结果显示,NAC保护组与肝损伤组相比,研究参数有显著改善。因此,我们可以得出结论,NAC通过改善肿瘤坏死因子- α、白细胞介素-6和还原型谷胱甘肽途径,在减轻CCL - 4诱导的肝损伤方面具有很大的潜力。
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引用次数: 0
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New Valley Veterinary Journal
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