Pub Date : 2026-01-21DOI: 10.1016/j.resuscitation.2026.110983
Daishi Xu, Eris van Twist, Marit Verboom, Maayke. Hunfeld, Corinne. Buysse, Geurt Jongbloed, Natasja M.S. de Groot, Robert van den Berg
{"title":"Prediction of Survival after Pediatric Cardiac Arrest using Heart Rate Variability and Machine Learning","authors":"Daishi Xu, Eris van Twist, Marit Verboom, Maayke. Hunfeld, Corinne. Buysse, Geurt Jongbloed, Natasja M.S. de Groot, Robert van den Berg","doi":"10.1016/j.resuscitation.2026.110983","DOIUrl":"https://doi.org/10.1016/j.resuscitation.2026.110983","url":null,"abstract":"","PeriodicalId":21052,"journal":{"name":"Resuscitation","volume":"38 1","pages":""},"PeriodicalIF":6.5,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146014326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-21DOI: 10.1016/j.resuscitation.2026.110980
Q.P.M. Omes, S. Nutma, A. Beishuizen, P.M.G. Filius, H.B. van der Worp, N.A. Foudraine, J.G. Krabbe, I.A. Strate, M.J.A.M. van Putten, J. Hofmeijer, Sjoukje Nutma, Albertus Beishuizen, Walter M. van den Bergh, Norbert A. Foudraine, Joost le Feber, P.Margreet G. Filius, Alexander D. Cornet, Job van der Palen, Michel J.A.M. van Putten, Jeannette Hofmeijer
{"title":"Serum biomarkers of postanoxic encephalopathy in relation to ghrelin treatment. A secondary analysis of the GRECO trial","authors":"Q.P.M. Omes, S. Nutma, A. Beishuizen, P.M.G. Filius, H.B. van der Worp, N.A. Foudraine, J.G. Krabbe, I.A. Strate, M.J.A.M. van Putten, J. Hofmeijer, Sjoukje Nutma, Albertus Beishuizen, Walter M. van den Bergh, Norbert A. Foudraine, Joost le Feber, P.Margreet G. Filius, Alexander D. Cornet, Job van der Palen, Michel J.A.M. van Putten, Jeannette Hofmeijer","doi":"10.1016/j.resuscitation.2026.110980","DOIUrl":"https://doi.org/10.1016/j.resuscitation.2026.110980","url":null,"abstract":"","PeriodicalId":21052,"journal":{"name":"Resuscitation","volume":"53 1","pages":""},"PeriodicalIF":6.5,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146014323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-20DOI: 10.1016/j.resuscitation.2026.110978
Marco Mion, Vicky L. Joshi
{"title":"Addressing fragmentation in cardiac arrest survivorship research: the Cardiac Arrest Research Hub","authors":"Marco Mion, Vicky L. Joshi","doi":"10.1016/j.resuscitation.2026.110978","DOIUrl":"https://doi.org/10.1016/j.resuscitation.2026.110978","url":null,"abstract":"","PeriodicalId":21052,"journal":{"name":"Resuscitation","volume":"63 1","pages":""},"PeriodicalIF":6.5,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146014331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-20DOI: 10.1016/j.resuscitation.2026.110974
Claudio Silwanis, Max Groche, Clemens Steinwender, Thomas Lambert
{"title":"Reply to: The Siren Song of the Chatbot: Persuasive Hallucinations and Automation Bias in OMI Detection","authors":"Claudio Silwanis, Max Groche, Clemens Steinwender, Thomas Lambert","doi":"10.1016/j.resuscitation.2026.110974","DOIUrl":"https://doi.org/10.1016/j.resuscitation.2026.110974","url":null,"abstract":"","PeriodicalId":21052,"journal":{"name":"Resuscitation","volume":"31 1","pages":""},"PeriodicalIF":6.5,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146000588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-18DOI: 10.1016/j.resuscitation.2026.110975
Zhang Liu, Weiqin Huang
{"title":"Very early EEG prognostication after cardiac arrest: disentangling biological signal from cohort enrichment","authors":"Zhang Liu, Weiqin Huang","doi":"10.1016/j.resuscitation.2026.110975","DOIUrl":"https://doi.org/10.1016/j.resuscitation.2026.110975","url":null,"abstract":"","PeriodicalId":21052,"journal":{"name":"Resuscitation","volume":"4 1","pages":""},"PeriodicalIF":6.5,"publicationDate":"2026-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145995286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-18DOI: 10.1016/j.resuscitation.2026.110976
Inayah Hodžić, Brian Doelkahar, Janneke Horn, Anne-Fleur van Rootselaar
{"title":"“Reply to: Very early EEG prognostication after cardiac arrest: disentangling biological signal from cohort enrichment”","authors":"Inayah Hodžić, Brian Doelkahar, Janneke Horn, Anne-Fleur van Rootselaar","doi":"10.1016/j.resuscitation.2026.110976","DOIUrl":"https://doi.org/10.1016/j.resuscitation.2026.110976","url":null,"abstract":"","PeriodicalId":21052,"journal":{"name":"Resuscitation","volume":"98 1","pages":""},"PeriodicalIF":6.5,"publicationDate":"2026-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145995287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-17DOI: 10.1016/j.resuscitation.2026.110973
Artur Dziewierz, Michał Chyrchel, Michał Terlecki
{"title":"The Siren Song of the Chatbot: Persuasive Hallucinations and Automation Bias in OMI Detection","authors":"Artur Dziewierz, Michał Chyrchel, Michał Terlecki","doi":"10.1016/j.resuscitation.2026.110973","DOIUrl":"https://doi.org/10.1016/j.resuscitation.2026.110973","url":null,"abstract":"","PeriodicalId":21052,"journal":{"name":"Resuscitation","volume":"39 1","pages":""},"PeriodicalIF":6.5,"publicationDate":"2026-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145995289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-16DOI: 10.1016/j.resuscitation.2026.110970
Jessica A. Barreto, Nishma Valikodath, Jessica P. Liu, Cailyn Rood, Valerie L. Ward, Ravi Thiagarajan, Edie A. Weller, Maryam Y. Naim, Katie Moynihan
OBJECTIVETo evaluate the association between Child Opportunity Index (COI) and race and ethnicity and pediatric out-of-hospital cardiac arrest (OHCA) outcomes and the role of bystander response (bystander cardiopulmonary resuscitation and/or defibrillator use) as a mediator.METHODSThis is a retrospective cohort study using the Cardiac Arrest Registry to Enhance Survival (CARES) of children ≤18 years with OHCA. The exposures are COI quintiles (very low indicates the most disadvantaged neighborhoods) and race and ethnicity. The primary outcome is survival to hospital discharge with favorable neurological outcome (Pediatric Cerebral Performance Category ≤2). Associations of exposures with outcome are determined using logistic regression and mediation analysis is used to evaluate the indirect effect of bystander response.RESULTSOverall, 1654/17903 (9.2%) had a favorable outcome. Arrests in lower COI neighborhoods and in Black/African American children occurred more frequently in infants and were less likely to be witnessed and to receive bystander response. Arrests in very low COI areas (vs very high COI, adjusted odds ratio aOR 0.68 [95% CI 0.54-0.84], P<.001) and Black/African American race (vs White, aOR 0.81 [95% CI 0.69-0.96], P=.02) were independently associated with lower odds of a favorable outcome. Lower bystander response partially mediated worse outcomes associated with lower COI quintiles (adjusted percent mediated: 11.7% [95% CI 5.5-17.9], P<.001) and Black/African American race (15.6% [95% CI 7.5-23.6], P<.001). Conclusions Arrests occurring in lower COI areas and among Black/African American children are associated with lower odds of a favorable outcome. Lower bystander response partially explains these associations.
目的评估儿童机会指数（COI）与种族和民族、儿童院外心脏骤停（OHCA）结局之间的关系，以及旁观者反应（旁观者心肺复苏和/或除颤器使用）作为中介的作用。方法：这是一项使用心脏骤停登记处提高18岁以下OHCA儿童生存率（CARES）的回顾性队列研究。暴露是COI的五分之一（非常低表明最弱势的社区）和种族和民族。主要终点是存活至出院时神经系统预后良好（儿科脑功能分类≤2）。使用逻辑回归确定暴露与结果的关联，并使用中介分析来评估旁观者反应的间接影响。结果1654/17903例（9.2%）患者预后良好。在低COI社区和黑人/非裔美国儿童中，逮捕更频繁地发生在婴儿身上，并且不太可能被目击并得到旁观者的回应。在非常低的COI地区（相对于非常高的COI，调整比值比aOR 0.68 [95% CI 0.54-0.84]， P<.001）和黑人/非裔美国人种族（相对于白人，aOR 0.81 [95% CI 0.69-0.96]， P=.02）的逮捕与较低的有利结果的几率独立相关。较低的旁观者反应部分介导了与较低COI五分位数相关的较差结果（调整百分比介导：11.7% [95% CI 5.5-17.9]， P<.001）和黑人/非裔美国人种族（15.6% [95% CI 7.5-23.6]， P<.001）。结论：在低COI地区和黑人/非裔美国儿童中发生的逮捕与较低的有利结果的几率相关。较低的旁观者反应部分解释了这些关联。
{"title":"Pediatric Out of Hospital Cardiac Arrest Outcomes by Child Opportunity Index, Race and Ethnicity","authors":"Jessica A. Barreto, Nishma Valikodath, Jessica P. Liu, Cailyn Rood, Valerie L. Ward, Ravi Thiagarajan, Edie A. Weller, Maryam Y. Naim, Katie Moynihan","doi":"10.1016/j.resuscitation.2026.110970","DOIUrl":"https://doi.org/10.1016/j.resuscitation.2026.110970","url":null,"abstract":"OBJECTIVETo evaluate the association between Child Opportunity Index (COI) and race and ethnicity and pediatric out-of-hospital cardiac arrest (OHCA) outcomes and the role of bystander response (bystander cardiopulmonary resuscitation and/or defibrillator use) as a mediator.METHODSThis is a retrospective cohort study using the Cardiac Arrest Registry to Enhance Survival (CARES) of children ≤18 years with OHCA. The exposures are COI quintiles (very low indicates the most disadvantaged neighborhoods) and race and ethnicity. The primary outcome is survival to hospital discharge with favorable neurological outcome (Pediatric Cerebral Performance Category ≤2). Associations of exposures with outcome are determined using logistic regression and mediation analysis is used to evaluate the indirect effect of bystander response.RESULTSOverall, 1654/17903 (9.2%) had a favorable outcome. Arrests in lower COI neighborhoods and in Black/African American children occurred more frequently in infants and were less likely to be witnessed and to receive bystander response. Arrests in very low COI areas (vs very high COI, adjusted odds ratio aOR 0.68 [95% CI 0.54-0.84], P<.001) and Black/African American race (vs White, aOR 0.81 [95% CI 0.69-0.96], P=.02) were independently associated with lower odds of a favorable outcome. Lower bystander response partially mediated worse outcomes associated with lower COI quintiles (adjusted percent mediated: 11.7% [95% CI 5.5-17.9], P<.001) and Black/African American race (15.6% [95% CI 7.5-23.6], P<.001). Conclusions Arrests occurring in lower COI areas and among Black/African American children are associated with lower odds of a favorable outcome. Lower bystander response partially explains these associations.","PeriodicalId":21052,"journal":{"name":"Resuscitation","volume":"20 1","pages":"110970"},"PeriodicalIF":6.5,"publicationDate":"2026-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145995291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-16DOI: 10.1016/j.resuscitation.2026.110969
N.T.A. Groeneveld, E.L.den Breejen, M. Bakker, M.G. van Vledder, J.H. Korstanje, E.G. Mik, I.M. Maissan
AIM OF THIS STUDYUnrecognized esophageal intubation during prehospital cardiopulmonary resuscitation (CPR) leads to inadequate oxygenation and ventilation and often results in death. This study describes and analyzes, using mathematical calculations, how esophageal capnography differs from normal capnography in out-of-hospital cardiac arrest (OHCA) patients, in order to assess whether these differences could support future detection.METHODSWe conducted a retrospective analysis using the Rotterdam Helicopter Emergency Medical Service (HEMS) database from January 2015 to November 2024. Cases of unrecognized esophageal intubation after ground EMS airway management were identified and analyzed for capnography waveform patterns before and after HEMS reintubation. HEMS data were supplemented with ambulance and monitor data from the Corpuls Manager database. Capnography waveforms were manually annotated and analyzed for CO2 levels, trend, area under the curve, and upslope.RESULTSOut of 5830 cases with intubation prior or during HEMS deployment, 92 were identified as esophageal intubations, with 14 cases involving OHCA in our region of interest with usable capnography. The median maximal esophageal CO2 was 2.5kPa, and the median maximal tracheal CO2 was 10.8kPa. Esophageal intubations showed a downward trend approaching near-zero values of CO2 within eight ventilations. Significant differences were found in the median corrected area under the curve and median upslope between esophageal and tracheal intubations.CONCLUSIONThis study uses analysis of waveform morphology to distinguish esophageal from tracheal intubation. While etCO2 values can appear numerically similar, the waveform morphology differs significantly. These findings represent an important first step toward developing automated tools for detecting inadequate ventilation by esophageal intubation. Larger datasets and prospective validation are needed before clinical implementation.
{"title":"Recognition of esophageal intubation in Dutch prehospital emergency medical services using capnography analysis: a retrospective cohort study","authors":"N.T.A. Groeneveld, E.L.den Breejen, M. Bakker, M.G. van Vledder, J.H. Korstanje, E.G. Mik, I.M. Maissan","doi":"10.1016/j.resuscitation.2026.110969","DOIUrl":"https://doi.org/10.1016/j.resuscitation.2026.110969","url":null,"abstract":"AIM OF THIS STUDYUnrecognized esophageal intubation during prehospital cardiopulmonary resuscitation (CPR) leads to inadequate oxygenation and ventilation and often results in death. This study describes and analyzes, using mathematical calculations, how esophageal capnography differs from normal capnography in out-of-hospital cardiac arrest (OHCA) patients, in order to assess whether these differences could support future detection.METHODSWe conducted a retrospective analysis using the Rotterdam Helicopter Emergency Medical Service (HEMS) database from January 2015 to November 2024. Cases of unrecognized esophageal intubation after ground EMS airway management were identified and analyzed for capnography waveform patterns before and after HEMS reintubation. HEMS data were supplemented with ambulance and monitor data from the Corpuls Manager database. Capnography waveforms were manually annotated and analyzed for CO2 levels, trend, area under the curve, and upslope.RESULTSOut of 5830 cases with intubation prior or during HEMS deployment, 92 were identified as esophageal intubations, with 14 cases involving OHCA in our region of interest with usable capnography. The median maximal esophageal CO2 was 2.5kPa, and the median maximal tracheal CO2 was 10.8kPa. Esophageal intubations showed a downward trend approaching near-zero values of CO2 within eight ventilations. Significant differences were found in the median corrected area under the curve and median upslope between esophageal and tracheal intubations.CONCLUSIONThis study uses analysis of waveform morphology to distinguish esophageal from tracheal intubation. While etCO2 values can appear numerically similar, the waveform morphology differs significantly. These findings represent an important first step toward developing automated tools for detecting inadequate ventilation by esophageal intubation. Larger datasets and prospective validation are needed before clinical implementation.","PeriodicalId":21052,"journal":{"name":"Resuscitation","volume":"30 1","pages":"110969"},"PeriodicalIF":6.5,"publicationDate":"2026-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145995290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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