Resuscitation最新文献

Background: Bystander cardiopulmonary resuscitation (CPR) for out-of-hospital cardiac arrest (OHCA) has increased in Singapore, Japan, and South Korea following the implementation of several public health, bystander-focused interventions, such as dispatcher-assisted CPR and community CPR training. It is unclear whether bystander CPR prevalence will continue on this trajectory over time. This study aimed to investigate the temporal trends of bystander CPR prevalence over a ten-year period in these three Asian countries.

Method: Using the national OHCA registries of Singapore, Japan and South Korea, we included witnessed, non-traumatic adult OHCA registered between 2010 and 2020 in Singapore and Japan, and between 2012 and 2020 in South Korea. We excluded those for whom resuscitation was not attempted or was terminated at scene. The study analysed the proportion of bystander CPR in the three countries, presenting the data annually and further breaking it down by age and gender.

Results: This study included 491,067 patients in Japan [male 59 %, median, age 79 years (Q1-Q3, 69-87)], 13,143 patients in Singapore [male 66 %, median, age 69 years (Q1-Q3, 57-80)], and 87,997 patients in South Korea [male 64 %, median age 72 years (Q1-Q3, 59-81)]. The proportion of bystander CPR in each country had increased (Japan: 39 % in 2010 to 45 % in 2015, Singapore: 22 % in 2010 to 53 % in 2015, and South Korea: 37 % in 2012 to 56 % in 2015); however, these proportions have plateaued in 2020 (Japan: 46 %, Singapore: 54 %, and South Korea: 57 %) despite continued efforts. These trends were consistent across different age groups, gender and location.

Conclusion: This study investigated the trend of bystander CPR over 10 years in three Asian countries. Although the proportion of bystander CPR has increased, it has now plateaued between 50-60 %. Further research is necessary to identify the contributing factors and advance beyond this "invisible ceiling".

Background: The impact and/or significance of gasping or apnea on cardio-respiratory status at birth remains unclear.

Objectives: The study objectives were to determine in infants presenting with gasping or apnea in the delivery room, initial heart rate (HR), responses to positive pressure ventilation (PPV), time to onset of spontaneous respirations, and the relationship of these responses to 24-hour outcome (death/survival) METHODS: Observation study undertaken in a rural setting involving late preterm and term newborns who gasped (n=126) or were apneic (n=105) at birth and received PPV had HR and respiratory parameters continuously measured and were video recorded.

Results: Apneic (12.3 %) versus gasping infants (5.7 %) were 7.2-fold more likely to die in the first 24 h (p = 0.01) and 2.8-fold more likely to die (p = 0.047) by 7 days. Initial HR was higher in gasping versus apneic infants (122 vs 105 bpm) (p = 0.01). Time to initiate breathing after starting PPV was significantly shorter in gasping versus apneic infants. No differences in applied peak inflation pressure, tidal volume, end tidal CO2, or resuscitation duration were noted. Of infants who died versus survivors, a HR < 100 bpm was observed more often in both gasping and apneic infants (p = 0.01) CONCLUSIONS: Infants who present with gasping versus apnea are less likely to die; apneic infants are more likely to die within the initial 24 h. Gasping versus apneic infants had a higher initial HR, were less likely to have a HR < 100 bmp and initiated spontaneous respiratory effort sooner after PPV. These findings are consistent with experimental and adult observations that suggest gasping appears critical to survival if PPV is initiated in a timely manner.

Aim: This cross-sectional study aimed to determine whether medical students with little to no ultrasound experience could correctly distinguish between 'pulsation present' and 'no pulsation present' after a short introductory video on the subject using ultrasound videos of the common carotid artery (CCA).

Methods: Ultrasound videos (B-mode, M-mode, and Color Doppler) of pulsatile (systolic blood pressure 70-80 mmHg) and non-pulsatile (cardiopulmonary bypass surgery, clamped aorta) CCA were created. These were demonstrated to the medical students for a period of ten seconds - corresponding to the duration of the manual pulse palpation during cardiopulmonary resuscitation (CPR). All participants viewed twenty of these videos in random order on a tablet and were asked to decide whether or not a CCA pulse was present.

Results: 432 participants completed the study in full on 20 cases, enabling a total of 8640 decisions on CCA pulse 'present' or 'not present' to be evaluated. M-mode: in 96 % (1244/1296) of the cases, the participants correctly identified the presence of pulsatile CCA. In the videos without pulsatile CCA, the correct decision 'no pulsation present' was made in 95 % (1231/1296) of the cases. B-mode: the decision 'pulsation present' was made correctly in 69 % (889/1296) of the cases, and in the remaining 31 % (407/1296) the option 'no pulsation present' was incorrectly chosen, although a video with CCA pulsation was shown. In contrast, the correct decision 'no pulsation present' was selected in 99 % of the cases (2142/2160). Color Doppler: CCA pulsation was correctly detected in 99.5 % (1290/1296) of the cases. In the videos without CCA pulsation, 99 % (1281/1296) of the videos were correctly evaluated as 'no pulsation present'.

Conclusion: Medical students seem to be able to detect the absence of a pulse with a high degree of accuracy using 2D ultrasound of the CCA in a controlled study setting, using different ultrasound modes. The results of this study suggest that a combination of Color Doppler and B-mode may be useful when evaluating the CCA during CPR to answer the question 'pulsation present' or 'no pulsation present'.

Introduction: Awakening from coma is crucial for survivors of cardiac arrest, though coma duration is variable. We tested the association of coma duration with short-term functional recovery and long-term survival after cardiac arrest.

Methods: In this retrospective cohort study, we identified post-arrest patients who were comatose on presentation but awakened during hospitalization. We recorded demographics, arrest characteristics, days from arrest to awakening, and modified Rankin Scale (mRS) at hospital discharge. We compared discharge mRS between patients with short and long coma duration dichotomized at its median, 3, and 6 days. We compared long-term survival between patients with short and long coma duration who survived to hospital discharge. Finally, we used Cox regression to quantify the independent association of coma duration with survival after adjusting for patient and arrest characteristics.

Results: We included 979 subjects with median coma duration 2 [IQR 1-4] days. Shorter coma duration was associated with a higher proportion of patients with discharge mRS ≤ 3 (p < 0.001). We observed 742 subjects who survived to discharge for 3,136 person-years and found no difference in long-term survival between short and long coma durations (p = 0.86). Coma duration was not associated with hazard of death (HR 1.00, 95 %CI 0.97-1.03) after adjusting for age, location of arrest, Charlson Comorbidity Index, and discharge mRS.

Conclusions: Shorter coma duration was associated with better functional outcome at discharge, but not with long-term survival.

Background: Cerebral edema after cardiac arrest can be quantified by the ratio of grey matter to white matter radiodensity (GWR) on computed tomography (CT). Severe edema predicts worse outcomes. We hypothesized the sensitivity and false positive rate of GWR predicting outcomes change over the first 24 hours post-arrest.

Methods: We performed a single-center retrospective cohort study including patients resuscitated from cardiac arrest between January 2010 and December 2023 who were unresponsive to verbal commands. We excluded patients who arrested from a primary traumatic or neurological etiology and those without brain imaging within 24 hours of arrest. We divided patients into groups based on time from arrest to CT, then quantified the performance of GWR dichotomized at <1.10 and <1.20, predicting in-hospital mortality and death by neurologic criteria (DNC).

Results: We included 2,204 patients with mean age 59 (SD 16) years. Overall, 1651 (75%) died in the hospital, of whom 248 (11%) progressed to DNC. Sensitivity of GWR <1.10 and GWR <1.20 for predicting in-hospital mortality increased over the first four hours post-arrest, reaching a maximum of 25% after five hours, while false positive rates remained <5% at all time points. Similar temporal trends were observed with DNC, although absolute values of sensitivity and false positive rate (FPR) varied.

Conclusion: The sensitivity and FPR of early GWR predicting in-hospital mortality and DNC after resuscitation from cardiac arrest varies over the initial post-arrest period. Reduced GWR on brain CTs is most sensitive for in-hospital mortality when obtained more than four hours post-arrest and for DNC when obtained between four and five hours. However, FPR remained execellent throughout, making early reductions in GWR a specific marker of poor outcome regardless of timing. While brain CTs obtained within the first 24 hours post-arrest may be indicated to evaluate for neurologic etiologies of arrest, they may be less informative as an independent marker of prognosis.

Introduction: Limited evidence supports guidelines to perform chest compressions at the lower half of the sternum. Imaging studies suggest this location may obstruct blood flow. Our primary aim was to compare the highest arterial line systolic blood pressure (SBP) during lower-half-of-sternum chest compressions (CC) versus those left-of-sternum, where the left ventricle is more likely located. Secondarily, we compared the highest end-tidal CO₂ (ETCO₂).

Methods: We conducted a retrospective cohort study of video-recorded, adult Emergency Department (ED) cardiac arrest resuscitations where changes in CC location were attempted to improve physiologic parameters (SBP, ETCO₂). We excluded epigastric and right-of-sternum compressions. Four CC zones were analyzed: recommended lower-half-of-sternum; left of lower-half-of-sternum; high left lateral; low left lateral. We combined all left-of-sternum compressions for analysis using linear mixed-effects models and multivariable mixed-effects controlling for manual vs. mechanical CCs.

Results: Among 24 patients analyzed, 20 (83.3 %) had initial compressions at the lower-half-of-sternum. 11 patients had 28 lower-half-of-sternum and 32 left-of-sternum CC intervals with available SBPs. In the mixed-effects model, least squares mean (LSMean) SBP was higher with left-of-sternum CCs (108.5 mmHg [95 % CI 88.3-128.8 mmHg]) versus lower-half-of-sternum CCs (66.7 mmHg [95 % CI 46.5-86.9 mmHg], p < 0.001). 18 patients had 44 lower-half-of-sternum and 32 left-of-sternum CC intervals with available ETCO₂. In the mixed-effects model, LSMean ETCO₂ was similar at the lower-half-of-sternum (20.4 mmHg [95 % CI 16.0-24.9 mmHg]) and left-of-sternum (22.6 mmHg [95 % CI 17.6-27.6 mmHg], p = 0.300). Results were similar when controlling for manual vs. mechanical CCs.

Conclusions: In our pilot, retrospective, observational study of select ED cardiac arrest patients, left-of-sternum chest compressions are associated with higher SBP than lower-half-of-sternum compressions, while ETCO₂ was similar.