Pub Date : 2026-03-17DOI: 10.1016/j.resuscitation.2026.111057
Kasper G. Lauridsen, Jimena del Castillo
{"title":"Tracheal Intubation and Chest Compression Pauses during Pediatric Cardiac Arrest: Are We Measuring the Right Endpoints?","authors":"Kasper G. Lauridsen, Jimena del Castillo","doi":"10.1016/j.resuscitation.2026.111057","DOIUrl":"https://doi.org/10.1016/j.resuscitation.2026.111057","url":null,"abstract":"","PeriodicalId":21052,"journal":{"name":"Resuscitation","volume":"20 1","pages":""},"PeriodicalIF":6.5,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147465376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-17DOI: 10.1016/j.resuscitation.2026.111063
Ábel Papp, Levente L Horváth, Zsófia Nagy, Anna Gaál, Róbert Debreczeni, Tünde Pintér, Endre Czeiter, Zoltán Vámos
Background: Post-cardiac arrest brain injury is driven by both global cerebral hypoperfusion and subsequent reperfusion. However, hyperacute blood-based neurobiomarker kinetics after precisely defined (very) low-flow intervals remain poorly characterized. During transcatheter aortic valve implantation (TAVI), rapid ventricular pacing (RVP) induces a transient pulseless ventricular tachycardia, functionally mimicking brief cardiac arrest.
Methods: In this single-centre, prospective, self-controlled cohort study, adults undergoing TAVI were enrolled. RVP (120-200 bpm) was applied to transiently suppress forward flow. Invasive aortic pressure, common carotid- (CCA) and middle cerebral artery (MCA) flow were recorded continuously. Serum samples were obtained pre-procedure and 20, 65, 110 and 200 minutes after RVP. Neuron specific enolase (NSE), and S100 were measured as neurobiomarkers.
Results: In case of the 76 enrolled patients, median cumulative RVP duration was 60 s (IQR 41-92). During RVP, MCA and CCA flow showed a very low-flow state while aortic pressure fell below the presumed autoregulatory threshold. NSE concentrations increased progressively from baseline to 200 minutes (T0: 10.6 [9.1-13.0]; T20: 12.8 [11.6-15.5]; T65: 15.1 [13.0-18.6]; T110: 15.8 [13.8-18.6]; T200: 17.0 [14.2-20.5] µg/L). S100B concentrations showed an inverse U-shaped profile (T0: 0.05 [0.04-0.07]; T20: 0.13 [0.10-0.18]; T65: 0.14 [0.11-0.23]; T110: 0.11 [0.08-0.16]; T200: 0.08 [0.06-0.12] µg/L). No patient developed neurological deficits.
Conclusions: Controlled (very) low-flow episodes during TAVI induce measurable, but clinically silent, elevations of NSE and S100. Neurobiomarkers reflects with distinct kinetics on ischaemia and reperfusion following a short, very low-flow cardiac arrest.
{"title":"POST-CARDIAC ARREST BRAIN INJURY MODEL: NEUROBIOMARKER KINETICS FOLLOWING GLOBAL CEREBRAL HYPOPERFUSION-REPERFUSION.","authors":"Ábel Papp, Levente L Horváth, Zsófia Nagy, Anna Gaál, Róbert Debreczeni, Tünde Pintér, Endre Czeiter, Zoltán Vámos","doi":"10.1016/j.resuscitation.2026.111063","DOIUrl":"https://doi.org/10.1016/j.resuscitation.2026.111063","url":null,"abstract":"<p><strong>Background: </strong>Post-cardiac arrest brain injury is driven by both global cerebral hypoperfusion and subsequent reperfusion. However, hyperacute blood-based neurobiomarker kinetics after precisely defined (very) low-flow intervals remain poorly characterized. During transcatheter aortic valve implantation (TAVI), rapid ventricular pacing (RVP) induces a transient pulseless ventricular tachycardia, functionally mimicking brief cardiac arrest.</p><p><strong>Methods: </strong>In this single-centre, prospective, self-controlled cohort study, adults undergoing TAVI were enrolled. RVP (120-200 bpm) was applied to transiently suppress forward flow. Invasive aortic pressure, common carotid- (CCA) and middle cerebral artery (MCA) flow were recorded continuously. Serum samples were obtained pre-procedure and 20, 65, 110 and 200 minutes after RVP. Neuron specific enolase (NSE), and S100 were measured as neurobiomarkers.</p><p><strong>Results: </strong>In case of the 76 enrolled patients, median cumulative RVP duration was 60 s (IQR 41-92). During RVP, MCA and CCA flow showed a very low-flow state while aortic pressure fell below the presumed autoregulatory threshold. NSE concentrations increased progressively from baseline to 200 minutes (T0: 10.6 [9.1-13.0]; T20: 12.8 [11.6-15.5]; T65: 15.1 [13.0-18.6]; T110: 15.8 [13.8-18.6]; T200: 17.0 [14.2-20.5] µg/L). S100B concentrations showed an inverse U-shaped profile (T0: 0.05 [0.04-0.07]; T20: 0.13 [0.10-0.18]; T65: 0.14 [0.11-0.23]; T110: 0.11 [0.08-0.16]; T200: 0.08 [0.06-0.12] µg/L). No patient developed neurological deficits.</p><p><strong>Conclusions: </strong>Controlled (very) low-flow episodes during TAVI induce measurable, but clinically silent, elevations of NSE and S100. Neurobiomarkers reflects with distinct kinetics on ischaemia and reperfusion following a short, very low-flow cardiac arrest.</p>","PeriodicalId":21052,"journal":{"name":"Resuscitation","volume":" ","pages":"111063"},"PeriodicalIF":4.6,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147487181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-14DOI: 10.1016/j.resuscitation.2026.111053
Graham Nichol, Norman Paradis
{"title":"You can’t Get What you Want (Til You Know What you Want)","authors":"Graham Nichol, Norman Paradis","doi":"10.1016/j.resuscitation.2026.111053","DOIUrl":"https://doi.org/10.1016/j.resuscitation.2026.111053","url":null,"abstract":"","PeriodicalId":21052,"journal":{"name":"Resuscitation","volume":"15 1","pages":"111053"},"PeriodicalIF":6.5,"publicationDate":"2026-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147465377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-14DOI: 10.1016/j.resuscitation.2026.111050
Simon Orlob, David Purkarthofer, Max Grobbel, Martin Holler, Michael Furtmüller, Johannes Wittig, Wolfgang J. Kern, Judith Martini, Jan-Thorsten Gräsner, Gabriel Putzer, Jan Wnent, Benjamin Hackl
{"title":"Multiplying Flow and Pressure: Detecting Respiratory Phases in Intra-Arrest Ventilation","authors":"Simon Orlob, David Purkarthofer, Max Grobbel, Martin Holler, Michael Furtmüller, Johannes Wittig, Wolfgang J. Kern, Judith Martini, Jan-Thorsten Gräsner, Gabriel Putzer, Jan Wnent, Benjamin Hackl","doi":"10.1016/j.resuscitation.2026.111050","DOIUrl":"https://doi.org/10.1016/j.resuscitation.2026.111050","url":null,"abstract":"","PeriodicalId":21052,"journal":{"name":"Resuscitation","volume":"53 1","pages":""},"PeriodicalIF":6.5,"publicationDate":"2026-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147447355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-14DOI: 10.1016/j.resuscitation.2026.111059
Bálint Bánfai, Henrietta Bánfai-Csonka
{"title":"Survival after out-of-hospital cardiac arrest: The role of on-scene bystanders and community first responders","authors":"Bálint Bánfai, Henrietta Bánfai-Csonka","doi":"10.1016/j.resuscitation.2026.111059","DOIUrl":"https://doi.org/10.1016/j.resuscitation.2026.111059","url":null,"abstract":"","PeriodicalId":21052,"journal":{"name":"Resuscitation","volume":"1 1","pages":"111059"},"PeriodicalIF":6.5,"publicationDate":"2026-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147465381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-14DOI: 10.1016/j.resuscitation.2026.111054
Marine Paul, Stéphane LEGRIEL
{"title":"Seeing more by measuring more: dual-index pupillometry for neuroprognostication after cardiac arrest","authors":"Marine Paul, Stéphane LEGRIEL","doi":"10.1016/j.resuscitation.2026.111054","DOIUrl":"https://doi.org/10.1016/j.resuscitation.2026.111054","url":null,"abstract":"","PeriodicalId":21052,"journal":{"name":"Resuscitation","volume":"22 1","pages":"111054"},"PeriodicalIF":6.5,"publicationDate":"2026-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147465378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-14DOI: 10.1016/j.resuscitation.2026.111056
Mohammed Aljanoubi, Keith Couper
{"title":"Response to “Publication isn’t implementation: AIRWAYS-2 and airway practice change”","authors":"Mohammed Aljanoubi, Keith Couper","doi":"10.1016/j.resuscitation.2026.111056","DOIUrl":"https://doi.org/10.1016/j.resuscitation.2026.111056","url":null,"abstract":"","PeriodicalId":21052,"journal":{"name":"Resuscitation","volume":"37 1","pages":"111056"},"PeriodicalIF":6.5,"publicationDate":"2026-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147465380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-10DOI: 10.1016/j.resuscitation.2026.111042
Morgann Loaec, Robert A Berg
{"title":"From Rescue to Recovery: Attempting to Find PaO2 and PaCO2 Targets After Pediatric ECPR.","authors":"Morgann Loaec, Robert A Berg","doi":"10.1016/j.resuscitation.2026.111042","DOIUrl":"https://doi.org/10.1016/j.resuscitation.2026.111042","url":null,"abstract":"","PeriodicalId":21052,"journal":{"name":"Resuscitation","volume":" ","pages":"111042"},"PeriodicalIF":4.6,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147444884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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