Pub Date : 2022-07-25DOI: 10.25135/rnp.342.2206.2475
Feng-qing Xu, De-Peng Wu, Lei Sun, Chui-Jian Kong, Huan Zhao
: Two new glycosides 2-hydroxy-4-methoxy-acetophenone-3- O -[ β -D-apiofuranosyl (1→6)- β -D-glucoside ( 1 ) and 4-hydroxy-2- O-β -rutinosyl acetophenone ( 2 ), along with two known compounds, paeonolide ( 3 ), involcranoside B ( 4 ) were isolated from the roots of Paeonia ostii . In addition, compound 4 was isolated from this genus for the first time. Their structures were established on the basis of spectral and chemical evidence. All the compounds showed inactive nitric oxide (NO) inhibitory effects.
{"title":"Two New Disaccharide Glycosides from the Root Cortex of Paeonia ostii","authors":"Feng-qing Xu, De-Peng Wu, Lei Sun, Chui-Jian Kong, Huan Zhao","doi":"10.25135/rnp.342.2206.2475","DOIUrl":"https://doi.org/10.25135/rnp.342.2206.2475","url":null,"abstract":": Two new glycosides 2-hydroxy-4-methoxy-acetophenone-3- O -[ β -D-apiofuranosyl (1→6)- β -D-glucoside ( 1 ) and 4-hydroxy-2- O-β -rutinosyl acetophenone ( 2 ), along with two known compounds, paeonolide ( 3 ), involcranoside B ( 4 ) were isolated from the roots of Paeonia ostii . In addition, compound 4 was isolated from this genus for the first time. Their structures were established on the basis of spectral and chemical evidence. All the compounds showed inactive nitric oxide (NO) inhibitory effects.","PeriodicalId":21053,"journal":{"name":"Records of Natural Products","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2022-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43071866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-17DOI: 10.25135/rnp.340.2202.2352
Nayara F. Gomes, Manoel Leão L. Júnior, Antônio José C. Filho, Lourivaldo S. Santos, Luís Cláudio N. Silva, E. Rodrigues-Filho
: Extracts of the endophytic fungus Glomerella cingulata grown in polish rice, were fractionated by chromatographic procedures including preparative scale HPLC. The isolated compounds were structurally elucidated through spectroscopic analysis, mainly 1 H and 13 C NMR and HRMS. These analyzes allowed the identification of pestalotin-1 ( 1 ) and the phthalides (3R*,8S*)-5,7-dihydroxy-3-(1-hydroxyethyl)-phthalide ( 2 ) and (3R*,8R*)-5,7-dihydroxy-3-(1-hydroxyethyl)-phthalide ( 3 ). The extracts, their fractions and isolated substances were tested against several bacteria. The lactone 2 showed some activity against lineages of E. coli and Enterococcus faecalis while its diastereomer 3 and pestalotin-1 were inactive
{"title":"Lactones from Glomerella cingulata Cultivated in Rice:Structural Studies and Antimicrobial Evaluation","authors":"Nayara F. Gomes, Manoel Leão L. Júnior, Antônio José C. Filho, Lourivaldo S. Santos, Luís Cláudio N. Silva, E. Rodrigues-Filho","doi":"10.25135/rnp.340.2202.2352","DOIUrl":"https://doi.org/10.25135/rnp.340.2202.2352","url":null,"abstract":": Extracts of the endophytic fungus Glomerella cingulata grown in polish rice, were fractionated by chromatographic procedures including preparative scale HPLC. The isolated compounds were structurally elucidated through spectroscopic analysis, mainly 1 H and 13 C NMR and HRMS. These analyzes allowed the identification of pestalotin-1 ( 1 ) and the phthalides (3R*,8S*)-5,7-dihydroxy-3-(1-hydroxyethyl)-phthalide ( 2 ) and (3R*,8R*)-5,7-dihydroxy-3-(1-hydroxyethyl)-phthalide ( 3 ). The extracts, their fractions and isolated substances were tested against several bacteria. The lactone 2 showed some activity against lineages of E. coli and Enterococcus faecalis while its diastereomer 3 and pestalotin-1 were inactive","PeriodicalId":21053,"journal":{"name":"Records of Natural Products","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2022-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46267592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-21DOI: 10.25135/rnp.337.2203.2391
M. Jauhar, I. Anshori, Michaella Yosephine, Putri Hawa Syaifie, Azza Hanif Harisna, D. W. Nugroho, E. Mardliyati, Adzani Gaisani Arda
: Type 2 diabetes mellitus is a disease caused by insulin resistance. Many types of oral medications exist, but the effectiveness and side effects differ from patient to patient, so alternative drugs are still required. One compound group receiving much scientific interest regarding its antidiabetic potential is xanthones as potential alpha-glucosidase and alpha-amylase inhibitors. This study performed molecular docking simulations on all 515 natural xanthones with alpha-glucosidase and alpha-amylase as the protein targets. We found 31 unique ligands that comply, and the three best ligands per protein target were filtered based on how many active site residues the ligands interacted with the targets. The three best alpha-glucosidase inhibitors are 3,4,5,8-tetrahydroxy-1,2-diisoprenylxanthone, Polygalaxanthone V, and Polygalaxanthone VII. As for alpha-amylase, we found 1-O-primeverosyl-3,8-dihydroxy-5-methoxyxanthone, Garcimangosone C, and Mangostinone as the best inhibitors. The six chosen and standard ligands underwent 2 ns molecular dynamics simulations. Both standard ligands had the highest interaction energies, followed by complexes with glycosylated xanthones, and prenylated xanthones. We also found that the prenylated xanthones could retain their initial protein-ligand interactions. Therefore, this is the first study that revealed prenylated xanthones have a good potential as anti-type 2 diabetes mellitus agents among other xanthones groups through in silico method.
2型糖尿病是由胰岛素抵抗引起的疾病。有很多类型的口服药物，但疗效和副作用因人而异，所以仍然需要替代药物。有一种化合物组由于其抗糖尿病的潜力而受到很多科学的关注，那就是作为α -葡萄糖苷酶和α -淀粉酶抑制剂的山酮类。本研究以α -葡萄糖苷酶和α -淀粉酶为蛋白靶点，对515种天然山酮进行了分子对接模拟。我们发现了31个独特的配体，并根据配体与靶标相互作用的活性位点残基的数量筛选了每个蛋白质靶标的三个最佳配体。三种最佳的α -葡萄糖苷酶抑制剂是3,4,5,8-四羟基-1,2-二异戊烯基口山酮、多花山酮V和多花山酮VII。对于α -淀粉酶，我们发现1- o -primeverosyl-3,8-二羟基-5-methoxyxanthone、Garcimangosone C和山竹酮是最好的抑制剂。选择的6种标准配体进行了2ns分子动力学模拟。两种标准配体的相互作用能最高，其次是糖基化的山酮配合物，其次是戊基化的山酮配合物。我们还发现，烯丙基化的山酮可以保留其最初的蛋白质-配体相互作用。因此，本研究首次通过硅化方法揭示了戊烯基化的山酮类药物在其他山酮类药物中具有良好的抗2型糖尿病药物潜力。
{"title":"In Silico Study of Natural Xanthones as Potential Inhibitors of Alpha-Glucosidase and Alpha-Amylase","authors":"M. Jauhar, I. Anshori, Michaella Yosephine, Putri Hawa Syaifie, Azza Hanif Harisna, D. W. Nugroho, E. Mardliyati, Adzani Gaisani Arda","doi":"10.25135/rnp.337.2203.2391","DOIUrl":"https://doi.org/10.25135/rnp.337.2203.2391","url":null,"abstract":": Type 2 diabetes mellitus is a disease caused by insulin resistance. Many types of oral medications exist, but the effectiveness and side effects differ from patient to patient, so alternative drugs are still required. One compound group receiving much scientific interest regarding its antidiabetic potential is xanthones as potential alpha-glucosidase and alpha-amylase inhibitors. This study performed molecular docking simulations on all 515 natural xanthones with alpha-glucosidase and alpha-amylase as the protein targets. We found 31 unique ligands that comply, and the three best ligands per protein target were filtered based on how many active site residues the ligands interacted with the targets. The three best alpha-glucosidase inhibitors are 3,4,5,8-tetrahydroxy-1,2-diisoprenylxanthone, Polygalaxanthone V, and Polygalaxanthone VII. As for alpha-amylase, we found 1-O-primeverosyl-3,8-dihydroxy-5-methoxyxanthone, Garcimangosone C, and Mangostinone as the best inhibitors. The six chosen and standard ligands underwent 2 ns molecular dynamics simulations. Both standard ligands had the highest interaction energies, followed by complexes with glycosylated xanthones, and prenylated xanthones. We also found that the prenylated xanthones could retain their initial protein-ligand interactions. Therefore, this is the first study that revealed prenylated xanthones have a good potential as anti-type 2 diabetes mellitus agents among other xanthones groups through in silico method.","PeriodicalId":21053,"journal":{"name":"Records of Natural Products","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2022-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41522469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
04, 2022) Abstract: Phytochemical investigation of Psammosilene tunicoides led to isolation of a new cyclicpeptide, psammosilenin C ( 1 ) and three known compounds, 1-O-( β -D-glucopyranosyl)-(2 S ,3 R ,4 E ,8 E )-2-[(2 R )-2-hydroxypentadecanoylamino]-4,8-octadecadiene-1,3-diol ( 2 ), dihydroferulic acid ( 3 ) and vanillylacetone ( 4 ). Their structures were elucidated by comprehensive spectroscopic methods, including 1D and 2D NMR spectroscopic, and HR-ESI-MS spectrometric data. Compounds 1 , 2 and 4 showed inhibitory activities on lipopolysaccharide (LPS)-induced NO release in RAW
{"title":"Psammosilenin C, a New Cyclic Peptide from Psammosilene tunicoides","authors":"Yanhong Li, Xiu-xia Yang, X. Bai, Hongrui Li, Jingxian Sun, Yong Xiong, Xiangzhong Huang","doi":"10.25135/rnp.336.2203.2399","DOIUrl":"https://doi.org/10.25135/rnp.336.2203.2399","url":null,"abstract":"04, 2022) Abstract: Phytochemical investigation of Psammosilene tunicoides led to isolation of a new cyclicpeptide, psammosilenin C ( 1 ) and three known compounds, 1-O-( β -D-glucopyranosyl)-(2 S ,3 R ,4 E ,8 E )-2-[(2 R )-2-hydroxypentadecanoylamino]-4,8-octadecadiene-1,3-diol ( 2 ), dihydroferulic acid ( 3 ) and vanillylacetone ( 4 ). Their structures were elucidated by comprehensive spectroscopic methods, including 1D and 2D NMR spectroscopic, and HR-ESI-MS spectrometric data. Compounds 1 , 2 and 4 showed inhibitory activities on lipopolysaccharide (LPS)-induced NO release in RAW","PeriodicalId":21053,"journal":{"name":"Records of Natural Products","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2022-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42000811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-06DOI: 10.25135/rnp.333.2203.2395
Do Hoang Giang, T. Phuong, N. Dang, Nguyen Thi Hong Anh, Dat Nguyen Tien
{"title":"A New Megastigmane Glycoside and Other Constituents from Amomum muricarpum Elmer","authors":"Do Hoang Giang, T. Phuong, N. Dang, Nguyen Thi Hong Anh, Dat Nguyen Tien","doi":"10.25135/rnp.333.2203.2395","DOIUrl":"https://doi.org/10.25135/rnp.333.2203.2395","url":null,"abstract":"","PeriodicalId":21053,"journal":{"name":"Records of Natural Products","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2022-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46532166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-06DOI: 10.25135/rnp.327.2203.2379
D. Yigit Hanoglu, A. Hanoğlu, B. Demirci, K. Baser
{"title":"The Essential Oil Compositions of Teucrium spp. Belonging to the Section Polium Schreb. (Lamiaceae) Growing in Cyprus","authors":"D. Yigit Hanoglu, A. Hanoğlu, B. Demirci, K. Baser","doi":"10.25135/rnp.327.2203.2379","DOIUrl":"https://doi.org/10.25135/rnp.327.2203.2379","url":null,"abstract":"","PeriodicalId":21053,"journal":{"name":"Records of Natural Products","volume":"1 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2022-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69542826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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