Pub Date : 2023-01-30DOI: 10.25135/rnp.378.2211.2627
Abbas Ali, N. Tabanca, V. Raman, Cristina Avanto, Xiangbing Yang, B. Demirci, A. Chittiboyina, I. Khan
{"title":"Chemical Compositions of Essential Oils from German, Roman, and Chinese Chamomile Flowers and Their Biological Activities against Three Economically Important Insect Pests","authors":"Abbas Ali, N. Tabanca, V. Raman, Cristina Avanto, Xiangbing Yang, B. Demirci, A. Chittiboyina, I. Khan","doi":"10.25135/rnp.378.2211.2627","DOIUrl":"https://doi.org/10.25135/rnp.378.2211.2627","url":null,"abstract":"","PeriodicalId":21053,"journal":{"name":"Records of Natural Products","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2023-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46758050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-26DOI: 10.25135/rnp.379.2210.2613
M. Mavis, Manal Salah Babiker Ali, A. Hanoğlu, Y. Ozalp, D. Özkum Yavuz, K. Baser, N. Serakinci
{"title":"Evaluation of Therapeutic role of Thymus capitatus (L.) Hoffm. & Link, Origanum dubium Boiss. Essential Oils and Their Major Constituents as Enhancers in Cancer Therapy","authors":"M. Mavis, Manal Salah Babiker Ali, A. Hanoğlu, Y. Ozalp, D. Özkum Yavuz, K. Baser, N. Serakinci","doi":"10.25135/rnp.379.2210.2613","DOIUrl":"https://doi.org/10.25135/rnp.379.2210.2613","url":null,"abstract":"","PeriodicalId":21053,"journal":{"name":"Records of Natural Products","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2023-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44767285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-07DOI: 10.25135/rnp.375.2211.2623
J. Wu, Linlin Qiu, Yanli Zhou, Shen Yao, Dubu Zhu
{"title":"A New Sesquiterpene and Two Nitro-containing Phenylpropionic Acid Derivatives from the Fungus Aspergillus terreus LPFH-1","authors":"J. Wu, Linlin Qiu, Yanli Zhou, Shen Yao, Dubu Zhu","doi":"10.25135/rnp.375.2211.2623","DOIUrl":"https://doi.org/10.25135/rnp.375.2211.2623","url":null,"abstract":"","PeriodicalId":21053,"journal":{"name":"Records of Natural Products","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2023-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42427337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.25135/rnp.335.2106.2092
Erdal Şanlidağ, İ. Çalış, H. Vatansever, K. Baser, E. Becer, A. Hanoğlu, Fatih Göger
: Amongst all cancer types, liver cancer is the fourth leading cause of cancer mortality. It is frequently stated as hepatocellular carcinoma (HCC) and occurs in hepatocytes. Genetic alterations of hepatocytes such as Wnt/β-catenin and JAK / STAT signaling pathways play a key role for the development of the HCC. Currently, there are a few available treatments for HCC; such treatments include transplantation, surgical resections and anti-cancer drugs. Most of the anti-cancer drugs target the signaling pathways for achieving an effective treatment. However, these treatments have some undesirable side effects. Thus, there is a need for discovering alternative anti-cancer agents with no or lesser side effects. Plant constituents are promising anti-cancer agents. Cynara cornigera L. contains plenty of phenolic compounds including quercetin, apigenin, etc. This study aimed to analyze the anti-cancer property of the fractionated methanol extract of the flowers of C. cornigera . All the fractions obtained were analyzed to determine the cytotoxic activity on HepG2 cells. Two of the fractions containing polyphenolic compounds had a significant cytotoxic activity related to non-canonical Wnt11 signaling pathways on HepG2 cells.
{"title":"The Effect of Cynara cornigera L. in HepG2 Hepatocellular Carcinoma Cells","authors":"Erdal Şanlidağ, İ. Çalış, H. Vatansever, K. Baser, E. Becer, A. Hanoğlu, Fatih Göger","doi":"10.25135/rnp.335.2106.2092","DOIUrl":"https://doi.org/10.25135/rnp.335.2106.2092","url":null,"abstract":": Amongst all cancer types, liver cancer is the fourth leading cause of cancer mortality. It is frequently stated as hepatocellular carcinoma (HCC) and occurs in hepatocytes. Genetic alterations of hepatocytes such as Wnt/β-catenin and JAK / STAT signaling pathways play a key role for the development of the HCC. Currently, there are a few available treatments for HCC; such treatments include transplantation, surgical resections and anti-cancer drugs. Most of the anti-cancer drugs target the signaling pathways for achieving an effective treatment. However, these treatments have some undesirable side effects. Thus, there is a need for discovering alternative anti-cancer agents with no or lesser side effects. Plant constituents are promising anti-cancer agents. Cynara cornigera L. contains plenty of phenolic compounds including quercetin, apigenin, etc. This study aimed to analyze the anti-cancer property of the fractionated methanol extract of the flowers of C. cornigera . All the fractions obtained were analyzed to determine the cytotoxic activity on HepG2 cells. Two of the fractions containing polyphenolic compounds had a significant cytotoxic activity related to non-canonical Wnt11 signaling pathways on HepG2 cells.","PeriodicalId":21053,"journal":{"name":"Records of Natural Products","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45115909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Research Progress on the Chemical Components and Pharmacological Activities of Gesneriaceae","authors":"Xiao-Rong Deng, Meng Li, Yingda Yang, Bowen Zhang, Weisheng Feng, Xiaoke Zheng, Jing-ke Zhang","doi":"10.25135/rnp.372.22.05.2470","DOIUrl":"https://doi.org/10.25135/rnp.372.22.05.2470","url":null,"abstract":"","PeriodicalId":21053,"journal":{"name":"Records of Natural Products","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2022-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46233140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-17DOI: 10.25135/rnp.373.2209.2588
Xiaomei Song, Haonan Xu, Yuanyuan Liu, Chenwang Liu, Chong Deng, Yi Jiang, Yu-ze Li, Dongdong Zhang, Wei Wang
{"title":"Triterpenoids and Pharmacological Activities from Kadsura (Schisandraceae) were gathered from 1987 to 2022","authors":"Xiaomei Song, Haonan Xu, Yuanyuan Liu, Chenwang Liu, Chong Deng, Yi Jiang, Yu-ze Li, Dongdong Zhang, Wei Wang","doi":"10.25135/rnp.373.2209.2588","DOIUrl":"https://doi.org/10.25135/rnp.373.2209.2588","url":null,"abstract":"","PeriodicalId":21053,"journal":{"name":"Records of Natural Products","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2022-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44545372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
: A new benzofuran, Cochinfuran A ( 1 ), and four known benzofurans ( 2-5 ) were isolated from the heartwood of Dalbergia cochinchinensis Pierre ex Laness. The chemical structure of the new benzofuran was determined based on broad NMR and mass spectrometry evaluation. Bioactivity assays showed that the compounds 1 - 3 and 5 were found as anti-inflammatory agents with IC 50 values 49.01 ± 1.54, 1368.93 ± 0.98, 67.48 ± 0.92 and 77.91 ± 1.53 μM, respectively. They could reduce the production of NO ( P <0.001) with 3.52~7.04, 1.96~7.84, 1.85~7.40 and 0.98~3.93 μM and restrained LDH ( P <0.01) with 3.52~7.04, 3.93~7.84, 3.70~7.40 and 0.98~3.93 μM in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages, respectively, the compound 4 (IC 50 218.20 ± 3.39 μM) showed no anti-inflammatory activity
{"title":"Anti-inflammatory Benzofurans from the Heartwood of Dalbergia cochinchinensis Pierre ex Laness","authors":"Qiwan Zheng, Ronghua Liu, Lanying Chen, Canyue Quyang, Xianwen Wei, Yang Liu, Jiahui Ren","doi":"10.25135/rnp.371.2210.2594","DOIUrl":"https://doi.org/10.25135/rnp.371.2210.2594","url":null,"abstract":": A new benzofuran, Cochinfuran A ( 1 ), and four known benzofurans ( 2-5 ) were isolated from the heartwood of Dalbergia cochinchinensis Pierre ex Laness. The chemical structure of the new benzofuran was determined based on broad NMR and mass spectrometry evaluation. Bioactivity assays showed that the compounds 1 - 3 and 5 were found as anti-inflammatory agents with IC 50 values 49.01 ± 1.54, 1368.93 ± 0.98, 67.48 ± 0.92 and 77.91 ± 1.53 μM, respectively. They could reduce the production of NO ( P <0.001) with 3.52~7.04, 1.96~7.84, 1.85~7.40 and 0.98~3.93 μM and restrained LDH ( P <0.01) with 3.52~7.04, 3.93~7.84, 3.70~7.40 and 0.98~3.93 μM in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages, respectively, the compound 4 (IC 50 218.20 ± 3.39 μM) showed no anti-inflammatory activity","PeriodicalId":21053,"journal":{"name":"Records of Natural Products","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2022-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42654579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：