Pub Date : 2022-04-01DOI: 10.21608/rpbs.2022.150356.1155
Sanaa A. Ahmed, Dalia A. Elbahy
Osteoporosis (O.P) is a metabolic bone disease characterized by bone mass loss and bone weakness. The cofactor in fatty acid beta-oxidation, L-carnitine (L-C), has been found to regulate osteoblast activity. Therefore, this work aimed to investigate the potential defensive properties of L-C versus dexamethasone (DEXA) induced O.P, as well as the underlying mechanisms. Thirty female Wistar rats were divided randomly into three equal groups (n = 10). The control group: received saline throughout the study; the DEXA-treated group: received DEXA (7 mg/kg/week) I.M. for four successive weeks; the L-C + DEXA treated group: received L-C (100 mg/kg/day, orally) for two weeks followed by L-C+ DEXA for a further four successive weeks simultaneously in the same previous doses and routes. L-C treatment attenuated the decline in femur and body weights, calcium, osteoprotegerin (OPG), and total antioxidant capacity resulting from DEXA administration. In contrast, L-C ameliorated DEXA-induced elevation in alkaline phosphatase and oxidative stress. Furthermore, L-C reduced the expression of an apoptosis-related gene; caspase-3, however, augmented the expression of autophagy-related genes ATG-5 and Smad-1 in rat bone. Histopathological findings further supported the protective effects of LC against DEXA-induced O.P. In conclusion, the current study findings demonstrated the protective effects of L-C on DEXA-induced O.P due to the reduction of oxidative stress, apoptosis, and increasing autophagy and smad-1 protein gene expression. Consequently, L-C can be used as an additive in the treatment of O.P.
{"title":"Autophagy, SMAD-1, and apoptotic pathways are correlated with L-carnitine protective effect against dexamethasone-induced osteoporosis in Wistar rats","authors":"Sanaa A. Ahmed, Dalia A. Elbahy","doi":"10.21608/rpbs.2022.150356.1155","DOIUrl":"https://doi.org/10.21608/rpbs.2022.150356.1155","url":null,"abstract":"Osteoporosis (O.P) is a metabolic bone disease characterized by bone mass loss and bone weakness. The cofactor in fatty acid beta-oxidation, L-carnitine (L-C), has been found to regulate osteoblast activity. Therefore, this work aimed to investigate the potential defensive properties of L-C versus dexamethasone (DEXA) induced O.P, as well as the underlying mechanisms. Thirty female Wistar rats were divided randomly into three equal groups (n = 10). The control group: received saline throughout the study; the DEXA-treated group: received DEXA (7 mg/kg/week) I.M. for four successive weeks; the L-C + DEXA treated group: received L-C (100 mg/kg/day, orally) for two weeks followed by L-C+ DEXA for a further four successive weeks simultaneously in the same previous doses and routes. L-C treatment attenuated the decline in femur and body weights, calcium, osteoprotegerin (OPG), and total antioxidant capacity resulting from DEXA administration. In contrast, L-C ameliorated DEXA-induced elevation in alkaline phosphatase and oxidative stress. Furthermore, L-C reduced the expression of an apoptosis-related gene; caspase-3, however, augmented the expression of autophagy-related genes ATG-5 and Smad-1 in rat bone. Histopathological findings further supported the protective effects of LC against DEXA-induced O.P. In conclusion, the current study findings demonstrated the protective effects of L-C on DEXA-induced O.P due to the reduction of oxidative stress, apoptosis, and increasing autophagy and smad-1 protein gene expression. Consequently, L-C can be used as an additive in the treatment of O.P.","PeriodicalId":21118,"journal":{"name":"Records of Pharmaceutical and Biomedical Sciences","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90829929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.21608/rpbs.2022.165136.1176
Salma M Selim, Reem M Hazem, Norhan M. El-Sayed, Hassan M. ElFayoumi
Streszczenie: Choroba Alzheimera jest jednym z najbardziej rozpowszechnionych schorzeñ neurodegeneracyjnych na wiecie. Etiologia tej choroby nie zosta3a jeszcze wyjaniona. Cech1 charakterystyczn1 tego schorzenia s1 zmiany morfologiczne, obecnoæ p3ytek starczych (zewn1trzkomórkowe agregaty peptydu amyloidu β Aβ) oraz splotów neurofibrylarnych (wewn1trzkomórkowe kompleksy hyperfosforylowanego bia3ka Tau), które s1 zlokalizowane w rejonach mózgu odpowiedzialnych za pamiêæ, uczenie siê oraz emocje. Krytyczne zmiany, które s1 istotne dla rozwoju choroby Alzheimera, powodowane s1 przez peptydy amyloidu β. W literaturze opisano szereg potencjalnych mechanizmów neurotoksycznoci ró¿nych form Aβ. Najwa¿niejsze z nich dotycz1 dysfunkcji mitochondriów, generacji wolnych rodników oraz zaburzeñ integralnoci b3on biologicznych. Peptydy Aβ powstaj1 w wyniku proteolitycznej obróbki bia3ka APP przez sekretazy: β oraz γ. Proces ten zachodzi przez ca3e ¿ycie cz3owieka. Upoledzenie mechanizmów zaanga¿owanych w zachowanie stê¿enia Aβ na nietoksycznym poziomie jest g3ówn1 przyczyn1 choroby Alzheimera. Znane s1 genetyczne oraz rodowiskowe czynniki ryzyka zachorowania na to schorzenie. mieræ komórek nerwowych jest prawdopodobnie skorelowana równie¿ z chronicznym stanem zapalnym stymulowanym w mózgu przez stale obecny Aβ. Liczne dowody wskazuj1 jednak na korzystne dzia3anie cytokin prozapalnych w aspekcie tego schorzenia. Rola mediatorów reakcji zapalnej w patogenezie choroby Alzheimera jest bardzo skomplikowana i nie do koñca wyjaniona. Ostatnio dokonano du¿ego postêpu w zrozumieniu molekularnych mechanizmów le¿1cych u podstaw choroby Alzheimera. Dziêki temu mo¿liwe by3o opracowanie szeregu potencjalnych terapeutyków, które mog1 mieæ zastosowanie w leczeniu przyczynowym tego schorzenia.
{"title":"Molecular mechanisms of Alzheimer's disease","authors":"Salma M Selim, Reem M Hazem, Norhan M. El-Sayed, Hassan M. ElFayoumi","doi":"10.21608/rpbs.2022.165136.1176","DOIUrl":"https://doi.org/10.21608/rpbs.2022.165136.1176","url":null,"abstract":"Streszczenie: Choroba Alzheimera jest jednym z najbardziej rozpowszechnionych schorzeñ neurodegeneracyjnych na wiecie. Etiologia tej choroby nie zosta3a jeszcze wyjaniona. Cech1 charakterystyczn1 tego schorzenia s1 zmiany morfologiczne, obecnoæ p3ytek starczych (zewn1trzkomórkowe agregaty peptydu amyloidu β Aβ) oraz splotów neurofibrylarnych (wewn1trzkomórkowe kompleksy hyperfosforylowanego bia3ka Tau), które s1 zlokalizowane w rejonach mózgu odpowiedzialnych za pamiêæ, uczenie siê oraz emocje. Krytyczne zmiany, które s1 istotne dla rozwoju choroby Alzheimera, powodowane s1 przez peptydy amyloidu β. W literaturze opisano szereg potencjalnych mechanizmów neurotoksycznoci ró¿nych form Aβ. Najwa¿niejsze z nich dotycz1 dysfunkcji mitochondriów, generacji wolnych rodników oraz zaburzeñ integralnoci b3on biologicznych. Peptydy Aβ powstaj1 w wyniku proteolitycznej obróbki bia3ka APP przez sekretazy: β oraz γ. Proces ten zachodzi przez ca3e ¿ycie cz3owieka. Upoledzenie mechanizmów zaanga¿owanych w zachowanie stê¿enia Aβ na nietoksycznym poziomie jest g3ówn1 przyczyn1 choroby Alzheimera. Znane s1 genetyczne oraz rodowiskowe czynniki ryzyka zachorowania na to schorzenie. mieræ komórek nerwowych jest prawdopodobnie skorelowana równie¿ z chronicznym stanem zapalnym stymulowanym w mózgu przez stale obecny Aβ. Liczne dowody wskazuj1 jednak na korzystne dzia3anie cytokin prozapalnych w aspekcie tego schorzenia. Rola mediatorów reakcji zapalnej w patogenezie choroby Alzheimera jest bardzo skomplikowana i nie do koñca wyjaniona. Ostatnio dokonano du¿ego postêpu w zrozumieniu molekularnych mechanizmów le¿1cych u podstaw choroby Alzheimera. Dziêki temu mo¿liwe by3o opracowanie szeregu potencjalnych terapeutyków, które mog1 mieæ zastosowanie w leczeniu przyczynowym tego schorzenia.","PeriodicalId":21118,"journal":{"name":"Records of Pharmaceutical and Biomedical Sciences","volume":"51 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80543797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.21608/rpbs.2022.145126.1152
Mariam H Fawzy, Dina M. Khodeer, Norhan M. El-Sayed, Noha M. Saeed, Yasser Ahmed
{"title":"Molecular mechanisms of cisplatin induced nephrotoxicity","authors":"Mariam H Fawzy, Dina M. Khodeer, Norhan M. El-Sayed, Noha M. Saeed, Yasser Ahmed","doi":"10.21608/rpbs.2022.145126.1152","DOIUrl":"https://doi.org/10.21608/rpbs.2022.145126.1152","url":null,"abstract":"","PeriodicalId":21118,"journal":{"name":"Records of Pharmaceutical and Biomedical Sciences","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77853215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.21608/rpbs.2022.121915.1124
Mohamed El gammal, Reem M Hazem, Y. Moustafa
{"title":"Mechanisms of Cadmium-Induced Testicular Damage","authors":"Mohamed El gammal, Reem M Hazem, Y. Moustafa","doi":"10.21608/rpbs.2022.121915.1124","DOIUrl":"https://doi.org/10.21608/rpbs.2022.121915.1124","url":null,"abstract":"","PeriodicalId":21118,"journal":{"name":"Records of Pharmaceutical and Biomedical Sciences","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76915789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.21608/rpbs.2022.135633.1135
Kholoud A. Elkashef
{"title":"Occult Hepatitis C Virus Infection: Is it time to get more attention!?","authors":"Kholoud A. Elkashef","doi":"10.21608/rpbs.2022.135633.1135","DOIUrl":"https://doi.org/10.21608/rpbs.2022.135633.1135","url":null,"abstract":"","PeriodicalId":21118,"journal":{"name":"Records of Pharmaceutical and Biomedical Sciences","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84595970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.21608/rpbs.2022.168918.1180
Tohada Al Noshokaty, Noha Mesbah, D. Abo-Elmatty, A. Abulsoud, A. Abdel-Hamed
{"title":"Hepatocellular carcinoma pathogenesis: Epigenetics and relationship with cancer hallmarks","authors":"Tohada Al Noshokaty, Noha Mesbah, D. Abo-Elmatty, A. Abulsoud, A. Abdel-Hamed","doi":"10.21608/rpbs.2022.168918.1180","DOIUrl":"https://doi.org/10.21608/rpbs.2022.168918.1180","url":null,"abstract":"","PeriodicalId":21118,"journal":{"name":"Records of Pharmaceutical and Biomedical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84051548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.21608/rpbs.2022.140001.1140
M. Azab, Marina W. Naguib, H. Shalaby
{"title":"Microbiological Evaluation of Minocycline Microspheres on the Type and Number of Bacteria in the Treatment of Chronic Periodontitis Using Multiplex PCR and Viable Counting: An in-Vivo study","authors":"M. Azab, Marina W. Naguib, H. Shalaby","doi":"10.21608/rpbs.2022.140001.1140","DOIUrl":"https://doi.org/10.21608/rpbs.2022.140001.1140","url":null,"abstract":"","PeriodicalId":21118,"journal":{"name":"Records of Pharmaceutical and Biomedical Sciences","volume":"56 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77140042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.21608/rpbs.2022.164715.1174
A. Radwan, M. Salim, Mahmoud M. Elkhoudary, Ghada M. Hadad, F. Belal
{"title":"Analytical approaches for the determination of Nebivolol","authors":"A. Radwan, M. Salim, Mahmoud M. Elkhoudary, Ghada M. Hadad, F. Belal","doi":"10.21608/rpbs.2022.164715.1174","DOIUrl":"https://doi.org/10.21608/rpbs.2022.164715.1174","url":null,"abstract":"","PeriodicalId":21118,"journal":{"name":"Records of Pharmaceutical and Biomedical Sciences","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82087250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.21608/rpbs.2022.141348.1146
Aya El Tanahy
{"title":"Antibacterial activity of Rubia tinctorum extracts.","authors":"Aya El Tanahy","doi":"10.21608/rpbs.2022.141348.1146","DOIUrl":"https://doi.org/10.21608/rpbs.2022.141348.1146","url":null,"abstract":"","PeriodicalId":21118,"journal":{"name":"Records of Pharmaceutical and Biomedical Sciences","volume":"65 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81151733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.21608/rpbs.2022.141371.1147
S. Gad, Ibrahim N. Mousa, T. Hamadi, Osama Sayed
{"title":"An evaluation of the effects of ethosomes in the delivery of transdermal drugs","authors":"S. Gad, Ibrahim N. Mousa, T. Hamadi, Osama Sayed","doi":"10.21608/rpbs.2022.141371.1147","DOIUrl":"https://doi.org/10.21608/rpbs.2022.141371.1147","url":null,"abstract":"","PeriodicalId":21118,"journal":{"name":"Records of Pharmaceutical and Biomedical Sciences","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73606126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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