Pub Date : 2022-04-01DOI: 10.21608/rpbs.2022.129863.1133
Safaa A. Faheem, Y. Moustafa, Norhan M El Sayed, Reem M Hazem, Noha M. Saeed
{"title":"Mechanisms of Cyclosporin A Induced Hepatotoxicity","authors":"Safaa A. Faheem, Y. Moustafa, Norhan M El Sayed, Reem M Hazem, Noha M. Saeed","doi":"10.21608/rpbs.2022.129863.1133","DOIUrl":"https://doi.org/10.21608/rpbs.2022.129863.1133","url":null,"abstract":"","PeriodicalId":21118,"journal":{"name":"Records of Pharmaceutical and Biomedical Sciences","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77822174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.21608/rpbs.2022.143995.1151
Mai M. Abo ElAzm
{"title":"Promoter methylation of certain tumor regulatory genes and hepatocellular carcinoma","authors":"Mai M. Abo ElAzm","doi":"10.21608/rpbs.2022.143995.1151","DOIUrl":"https://doi.org/10.21608/rpbs.2022.143995.1151","url":null,"abstract":"","PeriodicalId":21118,"journal":{"name":"Records of Pharmaceutical and Biomedical Sciences","volume":"118 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89862698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.21608/rpbs.2022.177461.1189
Eman A Ali
{"title":"Protective effect of curcumin on diclofenac sodium-induced hepatotoxicity in male albino rats: Evidence of its antioxidant and anti-inflammatory properties","authors":"Eman A Ali","doi":"10.21608/rpbs.2022.177461.1189","DOIUrl":"https://doi.org/10.21608/rpbs.2022.177461.1189","url":null,"abstract":"","PeriodicalId":21118,"journal":{"name":"Records of Pharmaceutical and Biomedical Sciences","volume":"85 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75181564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.21608/rpbs.2022.112889.1122
Hala I. Madkour, Safia B. Ahmed, W. Mohammed
This study aimed to investigate the effect of L-carnitine (L-car) supplementation on methotrexate (MTX) related ovarian dysfunction. Fifty female albino rats weighing 200 –250 g were randomly divided into five groups (10 rats each); the duration of the experiment was four weeks. Control group received saline (IP). MTX group received 1 mg/kg (IP) once weekly for four weeks. Whereas, MTX+L-car50, MTX+L-car100 and MTX+folic acid groups: daily received either L-car (50 or 100 mg/kg) or folic acid 250 µg/kg respectively (orally) plus 1 mg/kg methotrexate (IP) once weekly for four weeks. Treatment of the rats with MTX produced a significant decrease in body and ovarian weights, ovarian index, serum total antioxidant capacity (TAC) and serum anti-Müllerian hormone (AMH). However, serum total oxidant status (TOS), Oxidative stress index (OSI), ovarian tissue malondialdehyde (MDA), nitric oxide (NO) and caspase-3 levels were significantly increased. Besides, there were histological abnormalities in the ovarian tissues with a significant increase in antral follicles count (AFC). Administration of either L-car (50 or 100 mg/kg) or folic acid corrected the abnormal biochemical parameters and improved the histopathological abnormalities and AFC. These data suggested that L-car might protect against MTX-induced ovarian dysfunction in female rats through antioxidant, anti-apoptotic effects and improving the ovarian reserve.
{"title":"L-carnitine ameliorates methotrexate-induced ovarian dysfunction in female rats","authors":"Hala I. Madkour, Safia B. Ahmed, W. Mohammed","doi":"10.21608/rpbs.2022.112889.1122","DOIUrl":"https://doi.org/10.21608/rpbs.2022.112889.1122","url":null,"abstract":"This study aimed to investigate the effect of L-carnitine (L-car) supplementation on methotrexate (MTX) related ovarian dysfunction. Fifty female albino rats weighing 200 –250 g were randomly divided into five groups (10 rats each); the duration of the experiment was four weeks. Control group received saline (IP). MTX group received 1 mg/kg (IP) once weekly for four weeks. Whereas, MTX+L-car50, MTX+L-car100 and MTX+folic acid groups: daily received either L-car (50 or 100 mg/kg) or folic acid 250 µg/kg respectively (orally) plus 1 mg/kg methotrexate (IP) once weekly for four weeks. Treatment of the rats with MTX produced a significant decrease in body and ovarian weights, ovarian index, serum total antioxidant capacity (TAC) and serum anti-Müllerian hormone (AMH). However, serum total oxidant status (TOS), Oxidative stress index (OSI), ovarian tissue malondialdehyde (MDA), nitric oxide (NO) and caspase-3 levels were significantly increased. Besides, there were histological abnormalities in the ovarian tissues with a significant increase in antral follicles count (AFC). Administration of either L-car (50 or 100 mg/kg) or folic acid corrected the abnormal biochemical parameters and improved the histopathological abnormalities and AFC. These data suggested that L-car might protect against MTX-induced ovarian dysfunction in female rats through antioxidant, anti-apoptotic effects and improving the ovarian reserve.","PeriodicalId":21118,"journal":{"name":"Records of Pharmaceutical and Biomedical Sciences","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78561942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.21608/rpbs.2022.148635.1154
D. Hal, Enas E Eltamany, Reda F. A. Abdelhameed, Safwat Ahmed, A. Ibrahim, J. Badr
{"title":"Chemical Review on Zygophyllum genus","authors":"D. Hal, Enas E Eltamany, Reda F. A. Abdelhameed, Safwat Ahmed, A. Ibrahim, J. Badr","doi":"10.21608/rpbs.2022.148635.1154","DOIUrl":"https://doi.org/10.21608/rpbs.2022.148635.1154","url":null,"abstract":"","PeriodicalId":21118,"journal":{"name":"Records of Pharmaceutical and Biomedical Sciences","volume":"69 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81734728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.21608/rpbs.2022.162152.1169
A. Rizk, M. El-Azab, Reem M Hazem, H. Abdelrazek
{"title":"Inflammatory Mechanisms and Treatment of Myocardial Infarction","authors":"A. Rizk, M. El-Azab, Reem M Hazem, H. Abdelrazek","doi":"10.21608/rpbs.2022.162152.1169","DOIUrl":"https://doi.org/10.21608/rpbs.2022.162152.1169","url":null,"abstract":"","PeriodicalId":21118,"journal":{"name":"Records of Pharmaceutical and Biomedical Sciences","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84258822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.21608/rpbs.2021.86406.1109
Faten Al-Abkal, Dina M. Khodeer, Y. Moustafa
Pycnogenol (PYC) is a plant-based extract derived from the proprietary bark of the French maritime pine (Pinus pinaster ssp. atlantica) that exerts antioxidative, anti-inflammatory, and anti-platelet effects. The standardized extract is composed of phenolic compounds (catechin, epicatechin, and taxifolin), condensed flavonoids (classed as procyanidins/ proanthocyanidins) and phenolic acids (cinnamic acids and other glycosides). these phenolic compounds after being ingested, undergo biotransformation and are broken down in the colon by microbial enzymes yielding smaller, bioavailable molecules that can then be absorbed by the colon into the bloodstream and transported to tissues and organs. The pycnogenol possess a highly protective characteristics versus various cardiovascular dysfunctions, kidney diseases, hepatic dysfunctions, neuro cognitive disorder, diabetes, reproductive dysfunction and infertility, cancer, digestive, retinal disease. The present review illustrates the effect of Pycnogenol as antioxidant and anti-inflammatory effects along with anti-tumor influence as well. Pycnogenol was concluded to act as an antioxidant agent in different situation including heart stress, cardiovascular system abnormalities, kidney disease and hepatic disorders, so it can be used in combination with other medication such as Methotrexate to abolish its side effects.
{"title":"The possible protective effects and mechanisms of action of Pycnogenol: in vivo animals and human studies","authors":"Faten Al-Abkal, Dina M. Khodeer, Y. Moustafa","doi":"10.21608/rpbs.2021.86406.1109","DOIUrl":"https://doi.org/10.21608/rpbs.2021.86406.1109","url":null,"abstract":"Pycnogenol (PYC) is a plant-based extract derived from the proprietary bark of the French maritime pine (Pinus pinaster ssp. atlantica) that exerts antioxidative, anti-inflammatory, and anti-platelet effects. The standardized extract is composed of phenolic compounds (catechin, epicatechin, and taxifolin), condensed flavonoids (classed as procyanidins/ proanthocyanidins) and phenolic acids (cinnamic acids and other glycosides). these phenolic compounds after being ingested, undergo biotransformation and are broken down in the colon by microbial enzymes yielding smaller, bioavailable molecules that can then be absorbed by the colon into the bloodstream and transported to tissues and organs. The pycnogenol possess a highly protective characteristics versus various cardiovascular dysfunctions, kidney diseases, hepatic dysfunctions, neuro cognitive disorder, diabetes, reproductive dysfunction and infertility, cancer, digestive, retinal disease. The present review illustrates the effect of Pycnogenol as antioxidant and anti-inflammatory effects along with anti-tumor influence as well. Pycnogenol was concluded to act as an antioxidant agent in different situation including heart stress, cardiovascular system abnormalities, kidney disease and hepatic disorders, so it can be used in combination with other medication such as Methotrexate to abolish its side effects.","PeriodicalId":21118,"journal":{"name":"Records of Pharmaceutical and Biomedical Sciences","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83006403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.21608/rpbs.2021.83271.1106
M. Abdelaal
{"title":"Lamivudine: An antiviral drug with high risk factor for selection of resistance in HBV patients","authors":"M. Abdelaal","doi":"10.21608/rpbs.2021.83271.1106","DOIUrl":"https://doi.org/10.21608/rpbs.2021.83271.1106","url":null,"abstract":"","PeriodicalId":21118,"journal":{"name":"Records of Pharmaceutical and Biomedical Sciences","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76262847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.21608/rpbs.2021.99325.1117
Rasha M. Ahmed
{"title":"Greenness Assessment of Spectrofluorometric Method for Quantification of Ertugliflozin: Application to Dosage Form and Human Urine.","authors":"Rasha M. Ahmed","doi":"10.21608/rpbs.2021.99325.1117","DOIUrl":"https://doi.org/10.21608/rpbs.2021.99325.1117","url":null,"abstract":"","PeriodicalId":21118,"journal":{"name":"Records of Pharmaceutical and Biomedical Sciences","volume":"2016 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86660372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.21608/rpbs.2021.90979.1112
S. Zekry, H. Hassanean, Reda F. A. Abdelhameed, Eman S. Habib, Safwat Ahmed
{"title":"Metabolites and Biological Activities of some Pulicaria species (Asteraceae): mini-review","authors":"S. Zekry, H. Hassanean, Reda F. A. Abdelhameed, Eman S. Habib, Safwat Ahmed","doi":"10.21608/rpbs.2021.90979.1112","DOIUrl":"https://doi.org/10.21608/rpbs.2021.90979.1112","url":null,"abstract":"","PeriodicalId":21118,"journal":{"name":"Records of Pharmaceutical and Biomedical Sciences","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78847099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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