Pub Date : 2021-01-01DOI: 10.21608/RPBS.2020.41471.1075
Eman El-Bsoumy, Eman S. Habib, A. Ibrahim, Safwat Ahmed
{"title":"Phytochemical constituents and biological activities of Jasonia montana (Asteraceae)","authors":"Eman El-Bsoumy, Eman S. Habib, A. Ibrahim, Safwat Ahmed","doi":"10.21608/RPBS.2020.41471.1075","DOIUrl":"https://doi.org/10.21608/RPBS.2020.41471.1075","url":null,"abstract":"","PeriodicalId":21118,"journal":{"name":"Records of Pharmaceutical and Biomedical Sciences","volume":"311 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77909707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-01DOI: 10.21608/rpbs.2019.18952.1046
Heba Saber Mohammed
ABSTRACT Medicinal plants have been used since ancient times for treatment of various diseases. Many of the drugs available on the market today originated either directly or indirectly from bioactive compounds isolated from plants. Family Asteraceae is one of the largest families of flowering plants, comprising 1600 genera and almost 30000 species worldwide (Bisht et al., 2010). The genus Sonchus is a genus of flowering plants in the dandelion tribe of the Asteraceae Family. It consists mostly of annual herbs, but a few are perennial or woody herbs. Annual herbs, known as sow thistles, were used as food stock for animals, particularly for rabbits. They are also edible to humans as a leafy vegetable. In Chinese folk medicine, sow thistles have been used for the treatment of fever, inflammation, for detoxication and improvement of blood circulation. Recent advances in the ethnomedicinal, phytochemical, and pharmacological studies of this genus are reviewed in this paper (Muhammed et .,al 2012 ). Results showed that secondary metabolites isolated and identified from genus Sonchus were mainly terpenes, sterols, flavonoids, and coumarins. In vivo and in vitro pharmacological studies have shown that plants belonging to this genus exhibit various biological activities, including antioxidant, anti-inflammatory, antibacterial, antidepressant, anxiolytic, and anti-tumor activities (Jain et al., 2014). Further attention should be given to the study of species belonging to genus Sonchus especially regarding toxicological effects. Further research on Sonchus plants should be conducted using bioactivity-guided isolation strategies to isolate and identify the bioactive metabolites in this genus.
{"title":"Phytochemistry and Pharmacological Effects of Plants in Genus Sonchus (Asteraceae)","authors":"Heba Saber Mohammed","doi":"10.21608/rpbs.2019.18952.1046","DOIUrl":"https://doi.org/10.21608/rpbs.2019.18952.1046","url":null,"abstract":"ABSTRACT Medicinal plants have been used since ancient times for treatment of various diseases. Many of the drugs available on the market today originated either directly or indirectly from bioactive compounds isolated from plants. Family Asteraceae is one of the largest families of flowering plants, comprising 1600 genera and almost 30000 species worldwide (Bisht et al., 2010). The genus Sonchus is a genus of flowering plants in the dandelion tribe of the Asteraceae Family. It consists mostly of annual herbs, but a few are perennial or woody herbs. Annual herbs, known as sow thistles, were used as food stock for animals, particularly for rabbits. They are also edible to humans as a leafy vegetable. In Chinese folk medicine, sow thistles have been used for the treatment of fever, inflammation, for detoxication and improvement of blood circulation. Recent advances in the ethnomedicinal, phytochemical, and pharmacological studies of this genus are reviewed in this paper (Muhammed et .,al 2012 ). Results showed that secondary metabolites isolated and identified from genus Sonchus were mainly terpenes, sterols, flavonoids, and coumarins. In vivo and in vitro pharmacological studies have shown that plants belonging to this genus exhibit various biological activities, including antioxidant, anti-inflammatory, antibacterial, antidepressant, anxiolytic, and anti-tumor activities (Jain et al., 2014). Further attention should be given to the study of species belonging to genus Sonchus especially regarding toxicological effects. Further research on Sonchus plants should be conducted using bioactivity-guided isolation strategies to isolate and identify the bioactive metabolites in this genus.","PeriodicalId":21118,"journal":{"name":"Records of Pharmaceutical and Biomedical Sciences","volume":"337 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141228269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-01DOI: 10.21608/rpbs.2019.16511.1037
Mohammed Yehya Farag, Ali A. Abdelrahman, Emad Eldin Ahmed Ibrahim, E. Toraih, Marwa Azab
Infection is one of the primary causes of human mortality. In the intensive care units a serious complication of infection is sepsis and its complications severe sepsis and septic shock.Sepsis is a common and a life-threatening illness, which is considered as a serious public health problem. The incidence of sepsis differs from one place to another place across the world. We aim is to estimate the incidence of sepsis in main hospitals of Ismailia city and to compare this result with results from studies in intensive care units in hospitals in other cities and countries. An observational that has been done in intensive care units of main hospital in Ismailia city. This study showed that cumulative incidence of sepsis to be 5.5% in a period of seven months which is lower than the incidence of severe sepsis in SOAP study and some other studies conducted in United Kingdom, France, Australia and New Zealand.
{"title":"Incidence of sepsis in adult Patients in Intensive care units in Ismailia Main Hospitals","authors":"Mohammed Yehya Farag, Ali A. Abdelrahman, Emad Eldin Ahmed Ibrahim, E. Toraih, Marwa Azab","doi":"10.21608/rpbs.2019.16511.1037","DOIUrl":"https://doi.org/10.21608/rpbs.2019.16511.1037","url":null,"abstract":"Infection is one of the primary causes of human mortality. In the intensive care units a serious complication of infection is sepsis and its complications severe sepsis and septic shock.Sepsis is a common and a life-threatening illness, which is considered as a serious public health problem. The incidence of sepsis differs from one place to another place across the world. We aim is to estimate the incidence of sepsis in main hospitals of Ismailia city and to compare this result with results from studies in intensive care units in hospitals in other cities and countries. An observational that has been done in intensive care units of main hospital in Ismailia city. This study showed that cumulative incidence of sepsis to be 5.5% in a period of seven months which is lower than the incidence of severe sepsis in SOAP study and some other studies conducted in United Kingdom, France, Australia and New Zealand.","PeriodicalId":21118,"journal":{"name":"Records of Pharmaceutical and Biomedical Sciences","volume":"29 27","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141227172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-01DOI: 10.21608/RPBS.2019.12385.1033
Mangreed M. Atef, Norhan M. El-Sayed, Y. Mostafa, Amal A. M. Ahmed
Diabetic neuropathy (DN) is a common complication of diabetes mellitus and is associated with structural changes in the nerves. Nerve damage happen as a result of many factors including metabolic disorders, oxidative and nitrosative stress, changes in the blood vessels that supply the peripheral nerves and changes in ion channel expression in peripheral fibres. However, the molecular basis for DN is poorly understood. Adenosine monophosphate activated protein kinase (AMPK) has been shown to regulate the activity of some kinases including protein kinase B (AKT), mitogen-activated protein kinases (MAPK) and mammalian target of rapamycin complex 1 (mTORC1) that represent important signalling pathways modulating the function of peripheral nociceptive neurons. Donepezil can activate AMPK and exerts neuroprotective effects. Diabetic mice showed reduced expression of p-AMPK in sciatic nerves with consequent activation of AKT/MAPK/4EBP1. In addition, a significant upregulation of the N-Methyl-D-aspartate (NMDA) receptors in spinal cord of diabetic mice was observed. Therefore, Donepezil could be a potential pharmacological agent for management of DN.
糖尿病性神经病变(DN)是糖尿病的常见并发症，与神经结构改变有关。神经损伤的发生是多种因素的结果，包括代谢紊乱、氧化和亚硝化应激、供应周围神经的血管的变化和周围纤维离子通道表达的变化。然而，对DN的分子基础了解甚少。单磷酸腺苷活化蛋白激酶(AMPK)已被证明可以调节一些激酶的活性，包括蛋白激酶B (AKT)、丝裂原活化蛋白激酶(MAPK)和哺乳动物雷帕霉素靶蛋白复合物1 (mTORC1)，这些激酶代表了调节外周伤害性神经元功能的重要信号通路。多奈哌齐可激活AMPK，发挥神经保护作用。糖尿病小鼠坐骨神经中p-AMPK的表达降低，AKT/MAPK/4EBP1随之激活。此外，我们还观察到糖尿病小鼠脊髓n -甲基- d -天冬氨酸(NMDA)受体显著上调。因此，多奈哌齐可能是治疗DN的潜在药物。
{"title":"Recent Updates in Treatment of Diabetic Neuropathy","authors":"Mangreed M. Atef, Norhan M. El-Sayed, Y. Mostafa, Amal A. M. Ahmed","doi":"10.21608/RPBS.2019.12385.1033","DOIUrl":"https://doi.org/10.21608/RPBS.2019.12385.1033","url":null,"abstract":"Diabetic neuropathy (DN) is a common complication of diabetes mellitus and is associated with structural changes in the nerves. Nerve damage happen as a result of many factors including metabolic disorders, oxidative and nitrosative stress, changes in the blood vessels that supply the peripheral nerves and changes in ion channel expression in peripheral fibres. However, the molecular basis for DN is poorly understood. Adenosine monophosphate activated protein kinase (AMPK) has been shown to regulate the activity of some kinases including protein kinase B (AKT), mitogen-activated protein kinases (MAPK) and mammalian target of rapamycin complex 1 (mTORC1) that represent important signalling pathways modulating the function of peripheral nociceptive neurons. Donepezil can activate AMPK and exerts neuroprotective effects. Diabetic mice showed reduced expression of p-AMPK in sciatic nerves with consequent activation of AKT/MAPK/4EBP1. In addition, a significant upregulation of the N-Methyl-D-aspartate (NMDA) receptors in spinal cord of diabetic mice was observed. Therefore, Donepezil could be a potential pharmacological agent for management of DN.","PeriodicalId":21118,"journal":{"name":"Records of Pharmaceutical and Biomedical Sciences","volume":"204 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78764450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-01DOI: 10.21608/rpbs.2019.17031.1039
R. Moustafa, R. A. Salam, Mohamed Abdel Shakour, Diaa T. A. Youssef, Ghada M. Hadad
Monitoring of pollution levels of heavy metals in freshwater is significant to human health and environmental management. The objective of the current study was to monitor the freshwater quality in Suez Canal region, Egypt and to determine the efficacy of water treatment system in the removal of contaminates like heavy metals residues. The concentrations of some heavy metals (As, Cd, Cr, Pb, Hg, Ni, Cu, Mn) were determined in freshwater, treated water, in muscle of fish species (Tilapia nilotica) and sediment. The results of the study revealed that , all heavy metals concentrations in freshwater and treated water were within the permissible limits except, Lead concentration in treated water was higher than the permissible limits. In Port Said, all metals concentrations in both freshwater and treated water samples were within the permissible limits. Fish samples collected from the three governorates showed an increase in Cd and Pb levels. The heavy metals concentrations in sediment samples were remarkably high.
{"title":"Analysis And Pollution Assessment of Some Trace Heavy Metals in Freshwater, Drinking Water, Fish, and Sediments Samples in Suez Canal Region, Egypt by Flame Atomic Absorption Spectrometer","authors":"R. Moustafa, R. A. Salam, Mohamed Abdel Shakour, Diaa T. A. Youssef, Ghada M. Hadad","doi":"10.21608/rpbs.2019.17031.1039","DOIUrl":"https://doi.org/10.21608/rpbs.2019.17031.1039","url":null,"abstract":"Monitoring of pollution levels of heavy metals in freshwater is significant to human health and environmental management. The objective of the current study was to monitor the freshwater quality in Suez Canal region, Egypt and to determine the efficacy of water treatment system in the removal of contaminates like heavy metals residues. The concentrations of some heavy metals (As, Cd, Cr, Pb, Hg, Ni, Cu, Mn) were determined in freshwater, treated water, in muscle of fish species (Tilapia nilotica) and sediment. The results of the study revealed that , all heavy metals concentrations in freshwater and treated water were within the permissible limits except, Lead concentration in treated water was higher than the permissible limits. In Port Said, all metals concentrations in both freshwater and treated water samples were within the permissible limits. Fish samples collected from the three governorates showed an increase in Cd and Pb levels. The heavy metals concentrations in sediment samples were remarkably high.","PeriodicalId":21118,"journal":{"name":"Records of Pharmaceutical and Biomedical Sciences","volume":"45 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73039383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-01DOI: 10.21608/rpbs.2019.17049.1040
Nagat Ghareb, M. Elgawish
{"title":"Dеsign and Synthеsis of somе Azolеs Incorporating Sulphadiazinе Dеrivativеs as Protеin Tyrosinе Phosphatasе-1B inhibitors","authors":"Nagat Ghareb, M. Elgawish","doi":"10.21608/rpbs.2019.17049.1040","DOIUrl":"https://doi.org/10.21608/rpbs.2019.17049.1040","url":null,"abstract":"","PeriodicalId":21118,"journal":{"name":"Records of Pharmaceutical and Biomedical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74377867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-01DOI: 10.21608/rpbs.2019.17028.1038
R. Moustafa
The objective of this study was to monitor the freshwater quality in Suez Canal region, Egypt and to determine the efficacy of water treatment system in the removal of contaminates. The hydrographic parameters recorded were air and water temperatures, pH, electric conductivity (EC), turbidity, alkalinity, dissolved oxygen content (DO), chemical oxygen demand (COD), total dissolved solids (TDS), nitrate, nitrite, ammonium and phosphates. All measured physicochemical parameters of fresh water samples are within the acceptable limits except chemical oxygen demand (COD) is above the acceptable limits but all measured physicochemical parameters of treated (tap) water samples are within the acceptable limits. .
{"title":"Assessment of Physicochemical parameters of Freshwater and Tap Water in Suez Canal Region, Egypt","authors":"R. Moustafa","doi":"10.21608/rpbs.2019.17028.1038","DOIUrl":"https://doi.org/10.21608/rpbs.2019.17028.1038","url":null,"abstract":"The objective of this study was to monitor the freshwater quality in Suez Canal region, Egypt and to determine the efficacy of water treatment system in the removal of contaminates. The hydrographic parameters recorded were air and water temperatures, pH, electric conductivity (EC), turbidity, alkalinity, dissolved oxygen content (DO), chemical oxygen demand (COD), total dissolved solids (TDS), nitrate, nitrite, ammonium and phosphates. All measured physicochemical parameters of fresh water samples are within the acceptable limits except chemical oxygen demand (COD) is above the acceptable limits but all measured physicochemical parameters of treated (tap) water samples are within the acceptable limits. .","PeriodicalId":21118,"journal":{"name":"Records of Pharmaceutical and Biomedical Sciences","volume":"267 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77798302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-06-08DOI: 10.21608/RPBS.2019.10144.1023
A. T. Sakr
Over nutrition induced diseases such as obesity and type 2 diabetes involve neural deregulation of metabolic physiology. Many findings describe the roles of over nutrition-associated hypothalamic inflammation in neurodegeneration and impaired adult neurogenesis as well as defective neural stem cell regeneration and their significance in obesity and related disease. Metabolic disorders include oxidative stress, insulin resistance, obesity and inflammation. Collectively, metabolic syndrome perturbs brain function and increases the incidence of neurodegenerative diseases, reflecting the possible involvement of obesity induced metabolic syndrome in development of Alzheimer's disease (AD) which is the most common form of dementia. Its key symptoms include progressive decline in the memory, impairment in speech, language, spatial orientation and dysfunction in the sensor motor system . Alzheimer's disease (AD) is a chronic neurodegenerative disease that usually start slowly and worsens over time. It is the cause of 60-70% of cases of dementia . Several mechanisms have been described to understand pathology of AD including damaging groups of cholinergic neurons with down regulation of cholinergic markers accumulation of amyloid beta peptide (Aβ) forming extracellular senile plaques, aggregation of hyperphosphorylated tau to form intracellular neurofibrillary tangles and oxidative stress .
{"title":"OBESITY AND TYPE 3 DIABETES: NUTRITIONAL APPROACHES AND THERAPEUTIC IMPLICATION","authors":"A. T. Sakr","doi":"10.21608/RPBS.2019.10144.1023","DOIUrl":"https://doi.org/10.21608/RPBS.2019.10144.1023","url":null,"abstract":"Over nutrition induced diseases such as obesity and type 2 diabetes involve neural deregulation of metabolic physiology. Many findings describe the roles of over nutrition-associated hypothalamic inflammation in neurodegeneration and impaired adult neurogenesis as well as defective neural stem cell regeneration and their significance in obesity and related disease. Metabolic disorders include oxidative stress, insulin resistance, obesity and inflammation. Collectively, metabolic syndrome perturbs brain function and increases the incidence of neurodegenerative diseases, reflecting the possible involvement of obesity induced metabolic syndrome in development of Alzheimer's disease (AD) which is the most common form of dementia. Its key symptoms include progressive decline in the memory, impairment in speech, language, spatial orientation and dysfunction in the sensor motor system . Alzheimer's disease (AD) is a chronic neurodegenerative disease that usually start slowly and worsens over time. It is the cause of 60-70% of cases of dementia . Several mechanisms have been described to understand pathology of AD including damaging groups of cholinergic neurons with down regulation of cholinergic markers accumulation of amyloid beta peptide (Aβ) forming extracellular senile plaques, aggregation of hyperphosphorylated tau to form intracellular neurofibrillary tangles and oxidative stress .","PeriodicalId":21118,"journal":{"name":"Records of Pharmaceutical and Biomedical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84394009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-05-14DOI: 10.21608/RPBS.2019.12251.1032
Hala H Zaatout, D. Ghareeb, Alshimaa Abd-Elgwad, A. Ismael
Ulva lactuca is widespread green algae. In some regions, it is used in nutrition. Its nutrients include iron, protein, iodine, vitamins (A, B1, and C) and trace elements. Their extracts showed potential antibacterial, hypolipidemic, cardioprotective and chemoprotective activities. The main chemical constituents of Ulva lactuca methanolic crude extract and its fractions were investigated in this study using different phytochemical and chromatographic methods. Biologically guided fractionation of plants or seaweeds extracts is considered the first step in drug discovery. So, the algal crude extract was fractionated then in vitro bioscreened for the determination of diphenylpicrylhydrazyl (DPPH) antioxidant, (Nitric Oxide) NO radical scavenging and anti-inflammatory activities. Results showed that water fraction was the most active fraction. Phenolic content, detected from HPLC, play a role in the antioxidant activity. Finally, it can be concluded that Ulva water fraction is effective candidate to be used in the treatment of oxidative stress and related disorders
{"title":"Phytochemical, antioxidant, and anti-inflammatory screening of the Egyptian Ulva lactuca methanolic extract","authors":"Hala H Zaatout, D. Ghareeb, Alshimaa Abd-Elgwad, A. Ismael","doi":"10.21608/RPBS.2019.12251.1032","DOIUrl":"https://doi.org/10.21608/RPBS.2019.12251.1032","url":null,"abstract":"Ulva lactuca is widespread green algae. In some regions, it is used in nutrition. Its nutrients include iron, protein, iodine, vitamins (A, B1, and C) and trace elements. Their extracts showed potential antibacterial, hypolipidemic, cardioprotective and chemoprotective activities. The main chemical constituents of Ulva lactuca methanolic crude extract and its fractions were investigated in this study using different phytochemical and chromatographic methods. Biologically guided fractionation of plants or seaweeds extracts is considered the first step in drug discovery. So, the algal crude extract was fractionated then in vitro bioscreened for the determination of diphenylpicrylhydrazyl (DPPH) antioxidant, (Nitric Oxide) NO radical scavenging and anti-inflammatory activities. Results showed that water fraction was the most active fraction. Phenolic content, detected from HPLC, play a role in the antioxidant activity. Finally, it can be concluded that Ulva water fraction is effective candidate to be used in the treatment of oxidative stress and related disorders","PeriodicalId":21118,"journal":{"name":"Records of Pharmaceutical and Biomedical Sciences","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80265020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-05-14DOI: 10.21608/RPBS.2019.12031.1031
S. Mahmoud, D. Abo-Elmatty, N. Mesbah, E. Mehanna, M. Hafez
Type 2 diabetes mellitus (T2DM) is a common disease in the elderly, affecting around 20% of geriatrics. In cross-sectional studies, T2DM had various adverse health effects, including cognitive impairment. The association of T2DM with decreased cognitive function suggests that T2DM can contribute to Alzheimer's disease (AD) The relationship between T2DM and AD continues to grow rapidly. It has been suggested that AD can be considered "type 3 diabetes”. Along with the processing of amyloid precursor protein (APP) and tau phosphorylation, the molecular links between T2DM and AD provide clues for new therapeutic targets such as glucagon-like peptide-1 (GLP-1), butyrylcholinesterase and receptor for advanced glycosylation end products (AGE). A possible mechanism correlating T2DM and AD is the alteration in insulin signaling in the brain. Insulin signaling is involved in several neuronal functions, and plays a vital role in the pathophysiology of AD. Therefore, the modification of neuronal insulin signaling by diabetic conditions may contribute to AD progression. Another possible mechanism is cerebrovascular changes, a common pathological change observed in both diseases. The importance of amyloid beta peptide (Aβ) induced cerebrovascular dysfunction in AD has been reported, indicating that pathological interactions between AGE receptor and Aβ have a role in this disorder.
{"title":"Title: Biochemical linkage of type 2 diabetes mellitus and Alzheimer’s disease","authors":"S. Mahmoud, D. Abo-Elmatty, N. Mesbah, E. Mehanna, M. Hafez","doi":"10.21608/RPBS.2019.12031.1031","DOIUrl":"https://doi.org/10.21608/RPBS.2019.12031.1031","url":null,"abstract":"Type 2 diabetes mellitus (T2DM) is a common disease in the elderly, affecting around 20% of geriatrics. In cross-sectional studies, T2DM had various adverse health effects, including cognitive impairment. The association of T2DM with decreased cognitive function suggests that T2DM can contribute to Alzheimer's disease (AD) The relationship between T2DM and AD continues to grow rapidly. It has been suggested that AD can be considered \"type 3 diabetes”. Along with the processing of amyloid precursor protein (APP) and tau phosphorylation, the molecular links between T2DM and AD provide clues for new therapeutic targets such as glucagon-like peptide-1 (GLP-1), butyrylcholinesterase and receptor for advanced glycosylation end products (AGE). A possible mechanism correlating T2DM and AD is the alteration in insulin signaling in the brain. Insulin signaling is involved in several neuronal functions, and plays a vital role in the pathophysiology of AD. Therefore, the modification of neuronal insulin signaling by diabetic conditions may contribute to AD progression. Another possible mechanism is cerebrovascular changes, a common pathological change observed in both diseases. The importance of amyloid beta peptide (Aβ) induced cerebrovascular dysfunction in AD has been reported, indicating that pathological interactions between AGE receptor and Aβ have a role in this disorder.","PeriodicalId":21118,"journal":{"name":"Records of Pharmaceutical and Biomedical Sciences","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91239308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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