首页 > 最新文献

Radiology. Cardiothoracic imaging最新文献

英文 中文
Vanishing Cystic Air Spaces. 消失的囊性空气空间
IF 7 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2023-12-01 DOI: 10.1148/ryct.230200
Lucas de Pádua Gomes de Farias, Cesar Higa Nomura, Marcio Valente Yamada Sawamura
{"title":"Vanishing Cystic Air Spaces.","authors":"Lucas de Pádua Gomes de Farias, Cesar Higa Nomura, Marcio Valente Yamada Sawamura","doi":"10.1148/ryct.230200","DOIUrl":"10.1148/ryct.230200","url":null,"abstract":"","PeriodicalId":21168,"journal":{"name":"Radiology. Cardiothoracic imaging","volume":"5 6","pages":"e230200"},"PeriodicalIF":7.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11163238/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139080902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum for: Photon-counting Detector CT in Patients Pre- and Post-Transcatheter Aortic Valve Replacement. 勘误:光子计数探测器 CT 在经导管主动脉瓣置换术前后患者中的应用。
IF 7 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2023-12-01 DOI: 10.1148/ryct.239002
Judith van der Bie, Simran P Sharma, Marcel van Straten, Daniel Bos, Alexander Hirsch, Marcel L Dijkshoorn, Rik Adrichem, Nicolas M D A van Mieghem, Ricardo P J Budde
{"title":"Erratum for: Photon-counting Detector CT in Patients Pre- and Post-Transcatheter Aortic Valve Replacement.","authors":"Judith van der Bie, Simran P Sharma, Marcel van Straten, Daniel Bos, Alexander Hirsch, Marcel L Dijkshoorn, Rik Adrichem, Nicolas M D A van Mieghem, Ricardo P J Budde","doi":"10.1148/ryct.239002","DOIUrl":"10.1148/ryct.239002","url":null,"abstract":"","PeriodicalId":21168,"journal":{"name":"Radiology. Cardiothoracic imaging","volume":"5 6","pages":"e239002"},"PeriodicalIF":7.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11163236/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139080886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitral Annular Disjunction: Review of an Increasingly Recognized Mitral Valve Entity. 二尖瓣瓣环脱节:回顾日益被认可的二尖瓣实体。
IF 7 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2023-12-01 DOI: 10.1148/ryct.230131
Aishwarya Gulati, Vaibhav Gulati, Ray Hu, Prabhakar Shantha Rajiah, Jadranka Stojanovska, Jennifer Febbo, Harold I Litt, Behzad Pavri, Baskaran Sundaram

Mitral annular disjunction (MAD) refers to atrial displacement of the hinge point of the mitral valve annulus from the ventricular myocardium. MAD leads to paradoxical expansion of the annulus in systole and may often be associated with mitral valve prolapse (MVP), leaflet degeneration, myocardial and papillary muscle fibrosis, and, potentially, malignant cardiac arrhythmias. Patients with MAD and MVP may present similarly, and MAD is potentially the missing link in explaining why some patients with MVP experience adverse outcomes. Patients with a 5 mm or longer MAD distance have an elevated risk of malignant cardiac arrhythmia compared with those with a shorter MAD distance. Evaluation for MAD is an important component of cardiac imaging, especially in patients with MVP and unexplained cardiac arrhythmias. Cardiac MRI is an important diagnostic tool that aids in recognizing and quantifying MAD, MVP, and fibrosis in the papillary muscle and myocardium, which may predict and help improve outcomes following electrophysiology procedures and mitral valve surgery. This article reviews the history, pathophysiology, controversy, prevalence, clinical implications, and imaging considerations of MAD, focusing on cardiac MRI. Keywords: MR-Dynamic Contrast Enhanced, Cardiac, Mitral Valve, Mitral Annular Disjunction, Mitral Valve Prolapse, Floppy Mitral Valve, Cardiac MRI, Arrhythmia, Sudden Cardiac Death, Barlow Valve © RSNA, 2023.

二尖瓣瓣环脱节(MAD)是指二尖瓣瓣环的铰链点从心室心肌向心房移位。二尖瓣瓣环脱节会导致二尖瓣瓣环在收缩期发生矛盾性扩张,通常与二尖瓣脱垂(MVP)、瓣叶变性、心肌和乳头肌纤维化以及潜在的恶性心律失常有关。二尖瓣脱垂和二尖瓣关闭不全患者的表现可能相似,而二尖瓣脱垂可能是解释一些二尖瓣关闭不全患者出现不良预后的缺失环节。与 MAD 间距较短的患者相比,MAD 间距为 5 毫米或更长的患者发生恶性心律失常的风险更高。MAD 评估是心脏成像的重要组成部分,尤其是对 MVP 和不明原因心律失常患者。心脏磁共振成像是一种重要的诊断工具,有助于识别和量化 MAD、MVP 以及乳头肌和心肌的纤维化,从而预测并帮助改善电生理手术和二尖瓣手术后的预后。本文回顾了 MAD 的历史、病理生理学、争议、发病率、临床意义和成像注意事项,重点介绍了心脏磁共振成像。关键词:MADMR-动态对比增强,心脏,二尖瓣,二尖瓣环脱节,二尖瓣脱垂,二尖瓣松弛,心脏 MRI,心律失常,心脏性猝死,巴洛瓣 © RSNA, 2023.
{"title":"Mitral Annular Disjunction: Review of an Increasingly Recognized Mitral Valve Entity.","authors":"Aishwarya Gulati, Vaibhav Gulati, Ray Hu, Prabhakar Shantha Rajiah, Jadranka Stojanovska, Jennifer Febbo, Harold I Litt, Behzad Pavri, Baskaran Sundaram","doi":"10.1148/ryct.230131","DOIUrl":"10.1148/ryct.230131","url":null,"abstract":"<p><p>Mitral annular disjunction (MAD) refers to atrial displacement of the hinge point of the mitral valve annulus from the ventricular myocardium. MAD leads to paradoxical expansion of the annulus in systole and may often be associated with mitral valve prolapse (MVP), leaflet degeneration, myocardial and papillary muscle fibrosis, and, potentially, malignant cardiac arrhythmias. Patients with MAD and MVP may present similarly, and MAD is potentially the missing link in explaining why some patients with MVP experience adverse outcomes. Patients with a 5 mm or longer MAD distance have an elevated risk of malignant cardiac arrhythmia compared with those with a shorter MAD distance. Evaluation for MAD is an important component of cardiac imaging, especially in patients with MVP and unexplained cardiac arrhythmias. Cardiac MRI is an important diagnostic tool that aids in recognizing and quantifying MAD, MVP, and fibrosis in the papillary muscle and myocardium, which may predict and help improve outcomes following electrophysiology procedures and mitral valve surgery. This article reviews the history, pathophysiology, controversy, prevalence, clinical implications, and imaging considerations of MAD, focusing on cardiac MRI. <b>Keywords:</b> MR-Dynamic Contrast Enhanced, Cardiac, Mitral Valve, Mitral Annular Disjunction, Mitral Valve Prolapse, Floppy Mitral Valve, Cardiac MRI, Arrhythmia, Sudden Cardiac Death, Barlow Valve © RSNA, 2023.</p>","PeriodicalId":21168,"journal":{"name":"Radiology. Cardiothoracic imaging","volume":"5 6","pages":"e230131"},"PeriodicalIF":7.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11163248/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139080889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Artificial Intelligence-based Coronary Stenosis Quantification at Coronary CT Angiography versus Quantitative Coronary Angiography. 基于人工智能的冠状动脉 CT 血管造影术与定量冠状动脉血管造影术的冠状动脉狭窄量化对比。
IF 7 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2023-12-01 DOI: 10.1148/ryct.230124
James Dundas, Jonathon A Leipsic, Stephanie Sellers, Philipp Blanke, Patricia Miranda, Nicholas Ng, Sarah Mullen, David Meier, Mariama Akodad, Janarthanan Sathananthan, Carlos Collet, Bernard de Bruyne, Olivier Muller, Georgios Tzimas

Purpose To evaluate the performance of a new artificial intelligence (AI)-based tool by comparing the quantified stenosis severity at coronary CT angiography (CCTA) with a reference standard derived from invasive quantitative coronary angiography (QCA). Materials and Methods This secondary, post hoc analysis included 120 participants (mean age, 59.7 years ± 10.8 [SD]; 73 [60.8%] men, 47 [39.2%] women) from three large clinical trials (AFFECTS, P3, REFINE) who underwent CCTA and invasive coronary angiography with QCA. Quantitative analysis of coronary stenosis severity at CCTA was performed using an AI-based coronary stenosis quantification (AI-CSQ) software service. Blinded comparison between QCA and AI-CSQ was measured on a per-vessel and per-patient basis. Results The per-vessel AI-CSQ diagnostic sensitivity, specificity, accuracy, positive predictive value, and negative predictive value were 80%, 88%, 86%, 65%, and 94%, respectively, for diameter stenosis (DS) 50% or greater; and 78%, 92%, 91%, 47%, and 98%, respectively, for DS 70% or greater. The areas under the receiver operating characteristic curve (AUCs) to predict DS of 50% or greater and 70% or greater on a per-vessel basis were 0.92 (95% CI: 0.88, 0.95; P < .001) and 0.93 (95% CI: 0.89, 0.97; P < .001), respectively. The AUCs to predict DS of 50% or greater and 70% or greater on a per-patient basis were 0.93 (95% CI: 0.88, 0.97; P < .001) and 0.88 (95% CI: 0.81, 0.94; P < .001), respectively. Conclusion AI-CSQ at CCTA demonstrated a high diagnostic performance compared with QCA both on a per-patient and per-vessel basis, with high sensitivity for stenosis detection. Keywords: CT Angiography, Cardiac, Coronary Arteries Supplemental material is available for this article. Published under a CC BY 4.0 license.

目的 通过比较冠状动脉 CT 血管造影 (CCTA) 的量化狭窄严重程度与有创定量冠状动脉血管造影 (QCA) 的参考标准,评估基于人工智能 (AI) 的新工具的性能。材料与方法 该二次事后分析包括来自三项大型临床试验(AFFECTS、P3、REFINE)的 120 名参与者(平均年龄为 59.7 岁 ± 10.8 [SD];73 [60.8%] 名男性,47 [39.2%] 名女性),他们都接受了 CCTA 和带有 QCA 的有创冠状动脉造影检查。使用基于人工智能的冠状动脉狭窄量化(AI-CSQ)软件服务对 CCTA 的冠状动脉狭窄严重程度进行定量分析。QCA和AI-CSQ之间的盲比测量以每个血管和每个患者为基础。结果 每血管 AI-CSQ 诊断灵敏度、特异性、准确性、阳性预测值和阴性预测值分别为:直径狭窄 (DS) 50% 或以上时,分别为 80%、88%、86%、65% 和 94%;直径狭窄 (DS) 70% 或以上时,分别为 78%、92%、91%、47% 和 98%。预测每个血管的 DS 为 50%或以上和 70% 或以上的接收者操作特征曲线下面积(AUC)分别为 0.92 (95% CI: 0.88, 0.95; P < .001) 和 0.93 (95% CI: 0.89, 0.97; P < .001)。预测每名患者 DS 为 50%或以上和 70% 或以上的 AUC 分别为 0.93 (95% CI: 0.88, 0.97; P < .001) 和 0.88 (95% CI: 0.81, 0.94; P < .001)。结论 与 QCA 相比,CCTA 的 AI-CSQ 对每个患者和每个血管都有很高的诊断性能,对狭窄的检测具有很高的灵敏度。关键词CT血管造影 心脏 冠状动脉 本文有补充材料。以 CC BY 4.0 许可发布。
{"title":"Artificial Intelligence-based Coronary Stenosis Quantification at Coronary CT Angiography versus Quantitative Coronary Angiography.","authors":"James Dundas, Jonathon A Leipsic, Stephanie Sellers, Philipp Blanke, Patricia Miranda, Nicholas Ng, Sarah Mullen, David Meier, Mariama Akodad, Janarthanan Sathananthan, Carlos Collet, Bernard de Bruyne, Olivier Muller, Georgios Tzimas","doi":"10.1148/ryct.230124","DOIUrl":"10.1148/ryct.230124","url":null,"abstract":"<p><p>Purpose To evaluate the performance of a new artificial intelligence (AI)-based tool by comparing the quantified stenosis severity at coronary CT angiography (CCTA) with a reference standard derived from invasive quantitative coronary angiography (QCA). Materials and Methods This secondary, post hoc analysis included 120 participants (mean age, 59.7 years ± 10.8 [SD]; 73 [60.8%] men, 47 [39.2%] women) from three large clinical trials (AFFECTS, P3, REFINE) who underwent CCTA and invasive coronary angiography with QCA. Quantitative analysis of coronary stenosis severity at CCTA was performed using an AI-based coronary stenosis quantification (AI-CSQ) software service. Blinded comparison between QCA and AI-CSQ was measured on a per-vessel and per-patient basis. Results The per-vessel AI-CSQ diagnostic sensitivity, specificity, accuracy, positive predictive value, and negative predictive value were 80%, 88%, 86%, 65%, and 94%, respectively, for diameter stenosis (DS) 50% or greater; and 78%, 92%, 91%, 47%, and 98%, respectively, for DS 70% or greater. The areas under the receiver operating characteristic curve (AUCs) to predict DS of 50% or greater and 70% or greater on a per-vessel basis were 0.92 (95% CI: 0.88, 0.95; <i>P</i> < .001) and 0.93 (95% CI: 0.89, 0.97; <i>P</i> < .001), respectively. The AUCs to predict DS of 50% or greater and 70% or greater on a per-patient basis were 0.93 (95% CI: 0.88, 0.97; <i>P</i> < .001) and 0.88 (95% CI: 0.81, 0.94; <i>P</i> < .001), respectively. Conclusion AI-CSQ at CCTA demonstrated a high diagnostic performance compared with QCA both on a per-patient and per-vessel basis, with high sensitivity for stenosis detection. <b>Keywords:</b> CT Angiography, Cardiac, Coronary Arteries <i>Supplemental material is available for this article.</i> Published under a CC BY 4.0 license.</p>","PeriodicalId":21168,"journal":{"name":"Radiology. Cardiothoracic imaging","volume":"5 6","pages":"e230124"},"PeriodicalIF":7.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11163244/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139080882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anatomic Approach to Common and Uncommon Manifestations of Thoracic Leukemias with Radiologic-Pathologic Correlation. 胸腔白血病常见和不常见表现的解剖学方法与放射学病理学相关性》(Anatomic Approach to Common and Uncommon Manifestations of Thoracic Leukemias with Radiologic-Pathologic Correlation)。
IF 7 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2023-12-01 DOI: 10.1148/ryct.230151
Chi Wan Koo, Livia Maria Frota Lima, Allison Kerper, Ying-Chun Lo

Leukemias are hematopoietic malignancies characterized by the production of abnormal leukocytes in the bone marrow. Clinical manifestations arise from either bone marrow suppression or leukemic organ infiltration. Lymphadenopathy is the most common direct manifestation of intrathoracic leukemia. However, leukemic cells may also infiltrate the lungs, pleura, heart, bones, and soft tissues. Pulmonary complications in patients with leukemia typically include pneumonia, hemorrhage, pulmonary edema, and sequelae of leukemia treatment. However, pulmonary abnormalities can also be related directly to leukemia, including leukemic pulmonary infiltration. The direct, non-treatment-related effects of leukemia on intrathoracic structures will be the focus of this imaging essay. Given the typical anatomic approach for image interpretation, an organ-based depiction of common and less common intrathoracic findings directly caused by leukemic involvement is presented, emphasizing imaging findings with pathologic correlations. Keywords: Leukemia, Pulmonary, Thorax, Soft Tissues/Skin, Hematologic, Bone Marrow © RSNA, 2023.

白血病是以骨髓中产生异常白细胞为特征的造血恶性肿瘤。临床表现源于骨髓抑制或白血病器官浸润。淋巴腺病是胸腔内白血病最常见的直接表现。不过,白血病细胞也可能浸润肺部、胸膜、心脏、骨骼和软组织。白血病患者的肺部并发症通常包括肺炎、出血、肺水肿和白血病治疗后遗症。然而,肺部异常也可能与白血病直接相关,包括白血病肺部浸润。白血病对胸腔内部结构的直接、与治疗无关的影响将是本文成像的重点。鉴于图像解读的典型解剖方法,本文将以器官为基础,描述白血病直接导致的常见和较少见的胸腔内发现,并强调与病理学相关的成像发现。关键词白血病、肺、胸部、软组织/皮肤、血液学、骨髓 © RSNA, 2023.
{"title":"Anatomic Approach to Common and Uncommon Manifestations of Thoracic Leukemias with Radiologic-Pathologic Correlation.","authors":"Chi Wan Koo, Livia Maria Frota Lima, Allison Kerper, Ying-Chun Lo","doi":"10.1148/ryct.230151","DOIUrl":"10.1148/ryct.230151","url":null,"abstract":"<p><p>Leukemias are hematopoietic malignancies characterized by the production of abnormal leukocytes in the bone marrow. Clinical manifestations arise from either bone marrow suppression or leukemic organ infiltration. Lymphadenopathy is the most common direct manifestation of intrathoracic leukemia. However, leukemic cells may also infiltrate the lungs, pleura, heart, bones, and soft tissues. Pulmonary complications in patients with leukemia typically include pneumonia, hemorrhage, pulmonary edema, and sequelae of leukemia treatment. However, pulmonary abnormalities can also be related directly to leukemia, including leukemic pulmonary infiltration. The direct, non-treatment-related effects of leukemia on intrathoracic structures will be the focus of this imaging essay. Given the typical anatomic approach for image interpretation, an organ-based depiction of common and less common intrathoracic findings directly caused by leukemic involvement is presented, emphasizing imaging findings with pathologic correlations. <b>Keywords:</b> Leukemia, Pulmonary, Thorax, Soft Tissues/Skin, Hematologic, Bone Marrow © RSNA, 2023.</p>","PeriodicalId":21168,"journal":{"name":"Radiology. Cardiothoracic imaging","volume":"5 6","pages":"e230151"},"PeriodicalIF":7.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11163245/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139080881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New Ideas from Old Laws. 旧法新意
IF 7 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2023-12-01 DOI: 10.1148/ryct.230393
Timothy Fairbairn, Bjarne Linde Nørgaard
{"title":"New Ideas from Old Laws.","authors":"Timothy Fairbairn, Bjarne Linde Nørgaard","doi":"10.1148/ryct.230393","DOIUrl":"10.1148/ryct.230393","url":null,"abstract":"","PeriodicalId":21168,"journal":{"name":"Radiology. Cardiothoracic imaging","volume":"5 6","pages":"e230393"},"PeriodicalIF":7.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11163243/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139080890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Specific Ventilation in Severe Asthma Evaluated with Noncontrast Tidal Breathing 1H MRI. 用非对比潮气呼吸 1H 磁共振成像评估严重哮喘患者的特殊通气情况
IF 7 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2023-12-01 DOI: 10.1148/ryct.230054
Dante P I Capaldi, Norman B Konyer, Melanie Kjarsgaard, Anna Dvorkin-Gheva, Ronald J Dandurand, Parameswaran Nair, Sarah Svenningsen

Purpose To determine if proton (1H) MRI-derived specific ventilation is responsive to bronchodilator (BD) therapy and associated with clinical biomarkers of type 2 airway inflammation and airways dysfunction in severe asthma. Materials and Methods In this prospective study, 27 participants with severe asthma (mean age, 52 years ± 9 [SD]; 17 female, 10 male) and seven healthy controls (mean age, 47 years ± 16; five female, two male), recruited between 2018 and 2021, underwent same-day spirometry, respiratory oscillometry, and tidal breathing 1H MRI. Participants with severe asthma underwent all assessments before and after BD therapy, and type 2 airway inflammatory biomarkers were determined (blood eosinophil count, sputum eosinophil percentage, sputum eosinophil-free granules, and fraction of exhaled nitric oxide) to generate a cumulative type 2 biomarker score. Specific ventilation was derived from tidal breathing 1H MRI and its response to BD therapy, and relationships with biomarkers of type 2 airway inflammation and airway dysfunction were evaluated. Results Mean MRI specific ventilation improved with BD inhalation (from 0.07 ± 0.04 to 0.11 ± 0.04, P < .001). Post-BD MRI specific ventilation (P = .046) and post-BD change in MRI specific ventilation (P = .006) were greater in participants with asthma with type 2 low biomarkers compared with participants with type 2 high biomarkers of airway inflammation. Post-BD change in MRI specific ventilation was correlated with change in forced expiratory volume in 1 second (r = 0.40, P = .04), resistance at 5 Hz (r = -0.50, P = .01), resistance at 19 Hz (r = -0.42, P = .01), reactance area (r = -0.54, P < .01), and reactance at 5 Hz (r = 0.48, P = .01). Conclusion Specific ventilation evaluated with tidal breathing 1H MRI was responsive to BD therapy and was associated with clinical biomarkers of airways disease in participants with severe asthma. Keywords: MRI, Severe Asthma, Ventilation, Type 2 Inflammation Supplemental material is available for this article. © RSNA, 2023 See also the commentary by Moore and Chandarana in this issue.

目的 确定质子 (1H) MRI 衍生的特异性通气量是否对支气管扩张剂 (BD) 治疗有反应,以及是否与重症哮喘患者 2 型气道炎症和气道功能障碍的临床生物标记物相关。材料与方法 在这项前瞻性研究中,2018 年至 2021 年间招募的 27 名重症哮喘参与者(平均年龄为 52 岁 ± 9 [SD];17 名女性,10 名男性)和 7 名健康对照者(平均年龄为 47 岁 ± 16;5 名女性,2 名男性)接受了当天的肺活量测定、呼吸振荡测定和潮气式呼吸 1H 磁共振成像。患有严重哮喘的参与者在 BD 治疗前后接受了所有评估,并测定了 2 型气道炎症生物标志物(血液嗜酸性粒细胞计数、痰中嗜酸性粒细胞百分比、痰中无嗜酸性粒细胞颗粒和呼出一氧化氮分数),以生成 2 型生物标志物累积得分。通过潮气呼吸 1H 磁共振成像得出特定通气量及其对 BD 治疗的反应,并评估其与 2 型气道炎症和气道功能障碍生物标记物之间的关系。结果 吸入 BD 后,平均 MRI 比通气量有所改善(从 0.07 ± 0.04 到 0.11 ± 0.04,P < .001)。与气道炎症生物标记物含量高的 2 型哮喘患者相比,生物标记物含量低的 2 型哮喘患者在 BD 后的磁共振特定通气量(P = .046)和磁共振特定通气量在 BD 后的变化(P = .006)更大。磁共振成像特定通气量在 BD 后的变化与 1 秒内用力呼气量的变化(r = 0.40,P = .04)、5 赫兹阻力(r = -0.50,P = .01)、19 赫兹阻力(r = -0.42,P = .01)、反应面积(r = -0.54,P < .01)和 5 赫兹反应(r = 0.48,P = .01)相关。结论 通过潮气呼吸 1H 磁共振成像评估的特定通气量对 BD 治疗有反应,并且与重症哮喘患者气道疾病的临床生物标志物相关。关键词MRI、重症哮喘、通气、2 型炎症 本文有补充材料。RSNA, 2023 另请参阅本期 Moore 和 Chandarana 的评论。
{"title":"Specific Ventilation in Severe Asthma Evaluated with Noncontrast Tidal Breathing <sup>1</sup>H MRI.","authors":"Dante P I Capaldi, Norman B Konyer, Melanie Kjarsgaard, Anna Dvorkin-Gheva, Ronald J Dandurand, Parameswaran Nair, Sarah Svenningsen","doi":"10.1148/ryct.230054","DOIUrl":"10.1148/ryct.230054","url":null,"abstract":"<p><p>Purpose To determine if proton (<sup>1</sup>H) MRI-derived specific ventilation is responsive to bronchodilator (BD) therapy and associated with clinical biomarkers of type 2 airway inflammation and airways dysfunction in severe asthma. Materials and Methods In this prospective study, 27 participants with severe asthma (mean age, 52 years ± 9 [SD]; 17 female, 10 male) and seven healthy controls (mean age, 47 years ± 16; five female, two male), recruited between 2018 and 2021, underwent same-day spirometry, respiratory oscillometry, and tidal breathing <sup>1</sup>H MRI. Participants with severe asthma underwent all assessments before and after BD therapy, and type 2 airway inflammatory biomarkers were determined (blood eosinophil count, sputum eosinophil percentage, sputum eosinophil-free granules, and fraction of exhaled nitric oxide) to generate a cumulative type 2 biomarker score. Specific ventilation was derived from tidal breathing <sup>1</sup>H MRI and its response to BD therapy, and relationships with biomarkers of type 2 airway inflammation and airway dysfunction were evaluated. Results Mean MRI specific ventilation improved with BD inhalation (from 0.07 ± 0.04 to 0.11 ± 0.04, <i>P</i> < .001). Post-BD MRI specific ventilation (<i>P</i> = .046) and post-BD change in MRI specific ventilation (<i>P</i> = .006) were greater in participants with asthma with type 2 low biomarkers compared with participants with type 2 high biomarkers of airway inflammation. Post-BD change in MRI specific ventilation was correlated with change in forced expiratory volume in 1 second (<i>r</i> = 0.40, <i>P</i> = .04), resistance at 5 Hz (<i>r</i> = -0.50, <i>P</i> = .01), resistance at 19 Hz (<i>r</i> = -0.42, <i>P</i> = .01), reactance area (<i>r</i> = -0.54, <i>P</i> < .01), and reactance at 5 Hz (<i>r</i> = 0.48, <i>P</i> = .01). Conclusion Specific ventilation evaluated with tidal breathing <sup>1</sup>H MRI was responsive to BD therapy and was associated with clinical biomarkers of airways disease in participants with severe asthma. <b>Keywords:</b> MRI, Severe Asthma, Ventilation, Type 2 Inflammation <i>Supplemental material is available for this article.</i> © RSNA, 2023 See also the commentary by Moore and Chandarana in this issue.</p>","PeriodicalId":21168,"journal":{"name":"Radiology. Cardiothoracic imaging","volume":"5 6","pages":"e230054"},"PeriodicalIF":7.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11163249/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139080899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardiac MRI and Clinical Outcomes in TMEM43 Arrhythmogenic Cardiomyopathy. 心脏磁共振成像与 TMEM43 致心律失常性心肌病的临床结果
IF 7 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2023-12-01 DOI: 10.1148/ryct.230155
João Matos, Emmi Helle, Melanie Care, Yasbanoo Moayedi, Michael H Gollob, Paaladinesh Thavendiranathan, Danna Spears, Kate Hanneman

Arrhythmogenic cardiomyopathy is an inherited cardiomyopathy that can involve both ventricles. Several genes have been identified as pathogenic in arrhythmogenic cardiomyopathy, including TMEM43. However, there are limited data on cardiac MRI findings in patients with TMEM43 variants to date. In this case series, cardiac MRI findings and clinical outcomes are described in 14 patients with TMEM43 variants, including eight (57%) with the pathogenic p.Ser358Leu variant (six female patients; mean age, 33 years ± 15 [SD]) and six (43%) with a TMEM43 variant of unknown significance (three female patients; mean age, 38 years ± 11). MRI findings demonstrated left ventricular systolic dysfunction in eight (57%) patients and right ventricular dysfunction in four (29%) patients. Among the nine patients with late gadolinium enhancement imaging, left ventricular late gadolinium enhancement was present in seven (78%; all subepicardial) patients. In summary, TMEM43 variants are associated with high prevalence of subepicardial late gadolinium enhancement and left ventricular dysfunction. Keywords: Arrhythmogenic Cardiomyopathy, Arrhythmogenic Right Ventricular Cardiomyopathy, TMEM43, Cardiac MRI, Genetic Variants Supplemental material is available for this article.

致心律失常性心肌病是一种可累及双心室的遗传性心肌病。目前已发现多个致心律失常性心肌病的致病基因,其中包括 TMEM43。然而,迄今为止,有关 TMEM43 变体患者心脏磁共振成像结果的数据非常有限。本病例系列描述了 14 例 TMEM43 变异患者的心脏磁共振成像结果和临床预后,其中 8 例(57%)为致病性 p.Ser358Leu 变异(6 例女性患者;平均年龄为 33 岁 ± 15 [SD]),6 例(43%)为意义不明的 TMEM43 变异(3 例女性患者;平均年龄为 38 岁 ± 11)。核磁共振成像结果显示,8 名患者(57%)存在左心室收缩功能障碍,4 名患者(29%)存在右心室功能障碍。在九名有晚期钆增强成像的患者中,七名(78%;均为心外膜下)患者出现左心室晚期钆增强。总之,TMEM43变异与心外膜下晚期钆增强和左心室功能障碍的高发病率有关。关键词:心律失常性心肌病致心律失常性心肌病 致心律失常性右室心肌病 TMEM43 心脏核磁共振成像 基因变异体 本文有补充材料。
{"title":"Cardiac MRI and Clinical Outcomes in <i>TMEM43</i> Arrhythmogenic Cardiomyopathy.","authors":"João Matos, Emmi Helle, Melanie Care, Yasbanoo Moayedi, Michael H Gollob, Paaladinesh Thavendiranathan, Danna Spears, Kate Hanneman","doi":"10.1148/ryct.230155","DOIUrl":"10.1148/ryct.230155","url":null,"abstract":"<p><p>Arrhythmogenic cardiomyopathy is an inherited cardiomyopathy that can involve both ventricles. Several genes have been identified as pathogenic in arrhythmogenic cardiomyopathy, including <i>TMEM43</i>. However, there are limited data on cardiac MRI findings in patients with <i>TMEM43</i> variants to date. In this case series, cardiac MRI findings and clinical outcomes are described in 14 patients with <i>TMEM43</i> variants, including eight (57%) with the pathogenic p.Ser358Leu variant (six female patients; mean age, 33 years ± 15 [SD]) and six (43%) with a <i>TMEM43</i> variant of unknown significance (three female patients; mean age, 38 years ± 11). MRI findings demonstrated left ventricular systolic dysfunction in eight (57%) patients and right ventricular dysfunction in four (29%) patients. Among the nine patients with late gadolinium enhancement imaging, left ventricular late gadolinium enhancement was present in seven (78%; all subepicardial) patients. In summary, <i>TMEM43</i> variants are associated with high prevalence of subepicardial late gadolinium enhancement and left ventricular dysfunction. <b>Keywords:</b> Arrhythmogenic Cardiomyopathy, Arrhythmogenic Right Ventricular Cardiomyopathy, <i>TMEM43</i>, Cardiac MRI, Genetic Variants <i>Supplemental material is available for this article</i>.</p>","PeriodicalId":21168,"journal":{"name":"Radiology. Cardiothoracic imaging","volume":"5 6","pages":"e230155"},"PeriodicalIF":7.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11163247/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139080883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of CT-derived Internal Area in Failed Surgical Stented Bioprostheses for Valve-in-Valve Implantation. 鉴定瓣膜腔内植入手术失败的支架生物前列腺的 CT 内部面积。
IF 7 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2023-12-01 DOI: 10.1148/ryct.230103
Seung-Ah Lee, Hyun Jung Koo, Do-Yoon Kang, Jung-Min Ahn, Duk-Woo Park, Seung-Jung Park, Dae-Hee Kim, Joon-Won Kang, Dong Hyun Yang
{"title":"Identification of CT-derived Internal Area in Failed Surgical Stented Bioprostheses for Valve-in-Valve Implantation.","authors":"Seung-Ah Lee, Hyun Jung Koo, Do-Yoon Kang, Jung-Min Ahn, Duk-Woo Park, Seung-Jung Park, Dae-Hee Kim, Joon-Won Kang, Dong Hyun Yang","doi":"10.1148/ryct.230103","DOIUrl":"10.1148/ryct.230103","url":null,"abstract":"","PeriodicalId":21168,"journal":{"name":"Radiology. Cardiothoracic imaging","volume":"5 6","pages":"e230103"},"PeriodicalIF":7.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11163241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139080888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Coronary Plaque Assessment: An Argument for Applying Occam's Razor. 冠状动脉斑块评估:应用奥卡姆剃刀的一个论点。
IF 3.8 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2023-10-26 eCollection Date: 2023-10-01 DOI: 10.1148/ryct.230313
Maros Ferencik
{"title":"Coronary Plaque Assessment: An Argument for Applying Occam's Razor.","authors":"Maros Ferencik","doi":"10.1148/ryct.230313","DOIUrl":"10.1148/ryct.230313","url":null,"abstract":"","PeriodicalId":21168,"journal":{"name":"Radiology. Cardiothoracic imaging","volume":"5 5","pages":"e230313"},"PeriodicalIF":3.8,"publicationDate":"2023-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613923/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71426396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Radiology. Cardiothoracic imaging
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1