Reviews of environmental contamination and toxicology最新文献

Plastic has been an incredibly useful and indispensable material in all aspects of human life. Without it many advances in medicine, technology or industry would not have been possible. However, its easy accessibility and low cost have led to global misuse. Basically, the production of the plastics from different chemical agents is very easy but unfortunately difficult to reuse or recycle, and it is thrown away as litter, incinerated or disposed of in landfill. Plastic once in the environment begins to degrade to very small sizes. Thus, many animals mistake them for food, so plastic enters a marine, terrestrial or freshwater food web. These microplastics although chemically inert have been shown to act as tiny "bio-sponges" for harmful chemicals found in the environment changing the nature of a plastic particle from chemically harmless to potentially toxic. It was believed that microparticles would simply pass through the gastrointestinal tract of animals and humans with no biological effect. However, studies have shown that they are sometimes taken up and distributed throughout the circulatory and lymphatic system and may be stored in the fatty tissues of different organisms. The result of the uptake of them showed potential carcinogenic effects, liver dysfunction and endocrine disruption. This review focuses on micro- and nanoplastics and their way entering marine and freshwater food webs, with particular attention to microplastic trophic transfer, their toxic side effects and influence to the human consumer in health and safety in the future.

With the continued growth in plastic production, its ubiquitous use and insufficient waste management and disposal, the increased levels of plastics in the environment have led to growing ecological concerns. The breakdown of these plastic macromolecules to smaller micro and nanosized particles and their detection in the aerial, aquatic, marine and terrestrial environments has been reviewed extensively, especially for thermoplastics. However, the formation of micro and nanoplastics has typically been explained as a physical abrasion process, largely overlooking the underlying chemical structure-morphology correlations to the degradation mechanisms of the plastics. This is particularly true for the common commodity thermosets. This review focuses on the degradation pathways for the most widely produced commodity thermoplastics and thermosets into microplastics (MP)s and nanoplastics (NP)s, as well as their behaviour and associated toxicity. Special emphasis is placed on NPs, which are associated with greater risks for toxicity compared to MPs, due to their higher surface area to volume ratios. This review also assesses the current state of standardized detection and quantification methods as well as comprehensive regulations for these fragments in the aquatic environment.

Carbamazepine (CBZ) is among the ten most frequent pharmaceuticals that occur in the aquatic systems, with known effects on inhabiting organisms, including bivalves. Bivalves are important species in coastal ecosystems, often exhibiting a dominant biomass within invertebrate communities. These organisms play a major role in the functioning of the ecosystem and particularly in food webs (as suspension-feeders) and represent a significant fraction of the fisheries resource. They also have strong interactions with the environment, water and sediment and are considered good bioindicator species. The present paper reviews the known literature on the impacts of CBZ in biological endpoints of marine bivalves exposed to environmentally and non-environmentally relevant concentrations, highlighting differences in terms of biological responses, associated with exposure period, concentrations tested, and species used. Overall, the literature available showed that CBZ induces individual and sub-individual effects in marine bivalves (adults and life stages) and the most common effect reported was the induction of oxidative stress.

Despite the increasing use of silver nanoparticles in medical sciences, published studies on their interaction with nerve cells and evaluation of risks are dispersed. This systematic review and meta-analysis could be used to devise safety guidelines for the use of silver nanoparticles in industry and medicine to reduce adverse effects on the CNS.After extensive searches, the full text of 30 related studies was reviewed and data mining completed. Data were analyzed by calculating the mean of different ratios between treated and untreated groups. Linear regression between variables was evaluated by meta-regression. Subgroup analysis was also performed due to heterogeneity.Treatment with silver nanoparticles significantly reduced cell viability (SMD = -1.79%; 95% CI: -2.17 to -1.40; p < 0.0001). Concentration > 0.1 μg/mL could kill neurons, while lower concentration would not (SMD -0.258; 95% CI: -0.821 to 0.305; p = 369). In addition to the concentration, the coating, size of the nanoparticles, and cell type are also factors that influence SNP nerve cell toxicity. Measurement of apoptosis (SMD = 2.21; 95% CI: 1.62 to 2.80; p=0.001) and lactate dehydrogenase release rate (SMD = 0.9; 95% CI: 0.33 to 1.47; p < 0.0001) also confirmed the destructive effect of silver nanoparticles on nerve cells.

Soil is an essential part of our ecosystem and plays a crucial role as a nutrient source, provides habitat for plants and other organisms. Overuse of antibiotics has accelerated the development and dissemination of antibiotic resistant bacteria (ARB) and antibiotic resistance genes (ARGs). ARB and ARGs are recognized as emerging environmental contaminants causing soil pollution and serious risks to public health. ARB and ARGs are discharged into soils through several pathways. Application of manure in agriculture is one of the primary sources of ARB and ARGs dissemination in the soil. Different sources of contamination by ARB and ARGs were reviewed and analyzed as well as dissemination mechanisms in the soil. The effects of ARB and ARGs on soil bacterial community were evaluated. Furthermore, the impact of different sources of manure on soil microbial diversity as well as the effect of antibiotics on the development of ARB and ARGs in soils was analyzed. Human health risk assessments associated with the spreading of ARB and ARGs in soils were investigated. Finally, recommendations and mitigation strategies were proposed.

The impact of ambient particulate matter (PM) on public health has become a great global concern, which is especially prominent in developing countries. For health purposes, PM is typically defined by size, with the smaller particles having more health impacts. Particles with a diameter <2.5 μm are called PM_2.5. Initial research studies have focused on the impact of PM_2.5 on respiratory and cardiovascular diseases; nevertheless, an increasing number of data suggested that PM_2.5 may affect every organ system in the human body, and the kidney is of no exception. The kidney is vulnerable to particulate matter because most environmental toxins are concentrated by the kidney during filtration. According to the high morbidity and mortality related to chronic kidney disease, it is necessary to determine the effect of PM_2.5 on kidney disease and its mechanism that needs to be identified. To understand the current status of PM_2.5 in the atmosphere and their potential harmful kidney effects in different regions of the world this review article was prepared based on peer-reviewed scientific papers, scientific reports, and database from government organizations published after the year 1998. In this review, we focus on the worldwide epidemiological evidence linking PM_2.5 with chronic kidney disease and the effect of PM_2.5 on the chronic kidney disease (CKD) progression. At the same time, we also discuss the possible mechanisms of PM_2.5 exposure leading to kidney damage, in order to emphasize the contribution of PM_2.5 to kidney damage. A global database on PM_2.5 and kidney disease should be developed to provide new ideas for the prevention and treatment of kidney disease.

Fluorotelomer alcohols (FTOHs) are widely used as industrial raw materials due to their unique hydrophobic and oleophobic properties. However, because of accidental exposure to products containing FTOHs or with the widespread use of FTOHs, they tend to contaminate the water and the soil. There are reports demonstrating that FTOHs can cause various harmful effects in animals and humans (for example, neurotoxicity, hepatotoxicity, nephrotoxicity, immunotoxicity, endocrine-disrupting activity, and developmental and reproductive toxicities). Oxidative stress is related to a variety of toxic effects induced by FTOHs. To date, few reviews have addressed the relationship between the toxicity of FTOHs and oxidative stress. This article summarises research demonstrating that the toxicity induced by FTOHs correlates with oxidative stress and metabolism. Furthermore, during the metabolic process of FTOHs, a number of cytochrome P450 enzymes (CYP450) are involved and many metabolites are produced by these enzymes, which can induce oxidative stress. This is also reviewed.

The lure of increased productivity and crop yield has caused the imprudent use of pesticides in great quantity that has unfavorably affected environmental health. Pesticides are chemicals intended for avoiding, eliminating, and mitigating any pests that affect the crop. Lack of awareness, improper management, and negligent disposal of pesticide containers have led to the permeation of pesticide residues into the food chain and other environmental pathways, leading to environmental degradation. Sufficient steps must be undertaken at various levels to monitor and ensure judicious use of pesticides. Development of prediction models for optimum use of pesticides, pesticide management, and their impact would be of great help in monitoring and controlling the ill effects of excessive use of pesticides. This paper aims to present an exhaustive review of the prediction models developed and modeling strategies used to optimize the use of pesticides.

In the past two decades, increased production and usage of metallic nanoparticles (NPs) have inevitably increased their discharge into the different compartments of the environment, which ultimately paved the way for their uptake and accumulation in various trophic levels of the food chain. Due to these issues, several questions have been raised on the usage of NPs in everyday life and have become a matter of public health concern. Among the metallic NPs, Cu-based NPs have gained popularity due to their cost-effectiveness and multifarious promising uses. Several studies in the past represented the phytotoxicity of Cu-based NPs on plants. However, comprehensive knowledge is still lacking. Additionally, the impact of Cu-based NPs on soil organisms such as agriculturally important microbes, fungi, mycorrhiza, nematode, and earthworms is poorly studied. This review article critically analyses the literature data to achieve a more comprehensive knowledge on the toxicological profile of Cu-based NPs and increase our understanding of the effects of Cu-based NPs on aquatic and terrestrial plants as well as on soil microbial communities. The underlying mechanism of biotransformation of Cu-based NPs and the process of their penetration into plants have also been discussed herein. Overall, this review could provide valuable information to design rules and regulations for the safe disposal of Cu-based NPs into a sustainable environment.