Pub Date : 2025-09-29eCollection Date: 2025-01-01DOI: 10.1590/0037-8682-0065-2025
Karla Lange, Andrea Marchiol, Rafael Herazo, Marianela Menes, Carlota Monroy, Antonieta Rodas, Belter Alcántara, Karen Carrillo, María Jesús Pinazo
Background: Chagas disease remains a public health problem in Guatemala, with ongoing transmission, both regionally and globally. Diagnosis is complex and often inaccessible. This study evaluated the performance of rapid diagnostic tests for Trypanosoma cruzi infection in Jutiapa.
Methods: Three rapid tests were performed, and the results were compared with those of a diagnostic algorithm for chronic infection.
Results: Although all tests had high specificity, their sensitivities were suboptimal. The combined use of RDTs (Rapid Diagnostic Tests) slightly improved the sensitivity, but it remained below the ideal thresholds.
Conclusions: Further evaluation of RDTs is necessary to enhance access and simplify diagnostic algorithms.
{"title":"Performance evaluation of rapid diagnostic tests for Chagas disease in Jutiapa, Guatemala.","authors":"Karla Lange, Andrea Marchiol, Rafael Herazo, Marianela Menes, Carlota Monroy, Antonieta Rodas, Belter Alcántara, Karen Carrillo, María Jesús Pinazo","doi":"10.1590/0037-8682-0065-2025","DOIUrl":"10.1590/0037-8682-0065-2025","url":null,"abstract":"<p><strong>Background: </strong>Chagas disease remains a public health problem in Guatemala, with ongoing transmission, both regionally and globally. Diagnosis is complex and often inaccessible. This study evaluated the performance of rapid diagnostic tests for Trypanosoma cruzi infection in Jutiapa.</p><p><strong>Methods: </strong>Three rapid tests were performed, and the results were compared with those of a diagnostic algorithm for chronic infection.</p><p><strong>Results: </strong>Although all tests had high specificity, their sensitivities were suboptimal. The combined use of RDTs (Rapid Diagnostic Tests) slightly improved the sensitivity, but it remained below the ideal thresholds.</p><p><strong>Conclusions: </strong>Further evaluation of RDTs is necessary to enhance access and simplify diagnostic algorithms.</p>","PeriodicalId":21199,"journal":{"name":"Revista da Sociedade Brasileira de Medicina Tropical","volume":"58 ","pages":"e00652025"},"PeriodicalIF":2.3,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12479034/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145207589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-29eCollection Date: 2025-01-01DOI: 10.1590/0037-8682-0258-2025
Elif Gozgec, Cemile Altinkaya
{"title":"A rare case report of bezold abscess in a 9-month-old baby.","authors":"Elif Gozgec, Cemile Altinkaya","doi":"10.1590/0037-8682-0258-2025","DOIUrl":"10.1590/0037-8682-0258-2025","url":null,"abstract":"","PeriodicalId":21199,"journal":{"name":"Revista da Sociedade Brasileira de Medicina Tropical","volume":"58 ","pages":"e02582025"},"PeriodicalIF":2.3,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12479035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145207599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-29DOI: 10.1590/0037-8682-0221B-2023
[This corrects the article doi: 10.1590/0037-8682-0221-2023].
[这更正了文章doi: 10.1590/0037-8682-0221-2023]。
{"title":"Erratum.","authors":"","doi":"10.1590/0037-8682-0221B-2023","DOIUrl":"10.1590/0037-8682-0221B-2023","url":null,"abstract":"<p><p>[This corrects the article doi: 10.1590/0037-8682-0221-2023].</p>","PeriodicalId":21199,"journal":{"name":"Revista da Sociedade Brasileira de Medicina Tropical","volume":"58 ","pages":"e0221B2023"},"PeriodicalIF":2.3,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12479037/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145207564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-29eCollection Date: 2025-01-01DOI: 10.1590/0037-8682-0257-2025
Elif Gozgec, Muhammed Mukremin Bugdaci
{"title":"Orbital cellulitis following acute sinusitis in a neonate.","authors":"Elif Gozgec, Muhammed Mukremin Bugdaci","doi":"10.1590/0037-8682-0257-2025","DOIUrl":"10.1590/0037-8682-0257-2025","url":null,"abstract":"","PeriodicalId":21199,"journal":{"name":"Revista da Sociedade Brasileira de Medicina Tropical","volume":"58 ","pages":"e02572025"},"PeriodicalIF":2.3,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12479040/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145207610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-29eCollection Date: 2025-01-01DOI: 10.1590/0037-8682-0279-2025
M Alperen Kılıç, Hilal Kırmızıgül, Emre Emekli, Murat Tepe
{"title":"A Rare Case of Primary Musculoskeletal Hydatid Disease Involving the Deltoid Muscle and Humerus.","authors":"M Alperen Kılıç, Hilal Kırmızıgül, Emre Emekli, Murat Tepe","doi":"10.1590/0037-8682-0279-2025","DOIUrl":"10.1590/0037-8682-0279-2025","url":null,"abstract":"","PeriodicalId":21199,"journal":{"name":"Revista da Sociedade Brasileira de Medicina Tropical","volume":"58 ","pages":"e02792025"},"PeriodicalIF":2.3,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12479045/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145207463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-29eCollection Date: 2025-01-01DOI: 10.1590/0037-8682-0229-2025
Cemile Altınkaya, Adem Karaman
{"title":"A case of tuberculosis in the cavitary lesion suggestive of neoplasm.","authors":"Cemile Altınkaya, Adem Karaman","doi":"10.1590/0037-8682-0229-2025","DOIUrl":"10.1590/0037-8682-0229-2025","url":null,"abstract":"","PeriodicalId":21199,"journal":{"name":"Revista da Sociedade Brasileira de Medicina Tropical","volume":"58 ","pages":"e02292025"},"PeriodicalIF":2.3,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12479044/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145207480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-29eCollection Date: 2025-01-01DOI: 10.1590/0037-8682-0066-2025
Celal Yazıcı
{"title":"A Rare Cause of Granulomatous Lymphadenitis: Tularemia.","authors":"Celal Yazıcı","doi":"10.1590/0037-8682-0066-2025","DOIUrl":"10.1590/0037-8682-0066-2025","url":null,"abstract":"","PeriodicalId":21199,"journal":{"name":"Revista da Sociedade Brasileira de Medicina Tropical","volume":"58 ","pages":"e00662025"},"PeriodicalIF":2.3,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12479036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145207542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-22eCollection Date: 2025-01-01DOI: 10.1590/0037-8682-0184-2025
Rosângela Siqueira de Oliveira, Angela Pires Brandão, Fabiane Maria de Almeida Ferreira, Sonia Maria da Costa, Vera Lucia Maria da Silva, Lucilaine Ferrazoli, Erica Chimara, Juliana Maira Watanabe Pinhata
Background: In this study, we aimed to describe the mutations associated with first-line drug resistance in Mycobacterium tuberculosis complex (MTBC) isolates from São Paulo, Brazil, between 2019 and 2021.
Methods: Mutations in the coding regions of rpoB and katG genes and in the promoter region of the inhA gene in MTBC clinical isolates were detected using the GenoType MTBDRplus assay (LPA). All mutations inferred by LPA were sequenced.
Results: Of the 13,489 MTBC isolates with valid LPA results, 657 (4.9%) harbored mutations. The overall prevalence rates of rifampicin-resistant (RIF-R) tuberculosis (TB), isoniazid-resistant (INH-R) TB, and multidrug-resistant (MDR) TB were 1.5, 2.0, and 1.2%, respectively. A significant proportion of RIF-R isolates presented inferred rpoB mutations (89.1%), most of which were the borderline H445N mutation. The inhA promoter C-15T mutation was predominant among the INH-R isolates (52.8%). Most MDR isolates presented rpoB S450L + katG S315T1 mutations. Gene sequencing identified mutations not included in the catalogue of mutations published by the World Health Organization. Phenotypic drug susceptibility testing on isolates with inferred rpoB mutations revealed that the 0.5 µg/mL critical concentration of RIF failed to detect most borderline mutations when using the BACTEC MGIT 960 system.
Conclusions: These findings emphasize the need for continuous surveillance and the integration of molecular and phenotypic methods to ensure an accurate detection and management of drug-resistant TB in high-burden settings.
{"title":"Comprehensive analysis of mutations associated with rifampicin- and isoniazid-resistant tuberculosis in a high-burden setting.","authors":"Rosângela Siqueira de Oliveira, Angela Pires Brandão, Fabiane Maria de Almeida Ferreira, Sonia Maria da Costa, Vera Lucia Maria da Silva, Lucilaine Ferrazoli, Erica Chimara, Juliana Maira Watanabe Pinhata","doi":"10.1590/0037-8682-0184-2025","DOIUrl":"10.1590/0037-8682-0184-2025","url":null,"abstract":"<p><strong>Background: </strong>In this study, we aimed to describe the mutations associated with first-line drug resistance in Mycobacterium tuberculosis complex (MTBC) isolates from São Paulo, Brazil, between 2019 and 2021.</p><p><strong>Methods: </strong>Mutations in the coding regions of rpoB and katG genes and in the promoter region of the inhA gene in MTBC clinical isolates were detected using the GenoType MTBDRplus assay (LPA). All mutations inferred by LPA were sequenced.</p><p><strong>Results: </strong>Of the 13,489 MTBC isolates with valid LPA results, 657 (4.9%) harbored mutations. The overall prevalence rates of rifampicin-resistant (RIF-R) tuberculosis (TB), isoniazid-resistant (INH-R) TB, and multidrug-resistant (MDR) TB were 1.5, 2.0, and 1.2%, respectively. A significant proportion of RIF-R isolates presented inferred rpoB mutations (89.1%), most of which were the borderline H445N mutation. The inhA promoter C-15T mutation was predominant among the INH-R isolates (52.8%). Most MDR isolates presented rpoB S450L + katG S315T1 mutations. Gene sequencing identified mutations not included in the catalogue of mutations published by the World Health Organization. Phenotypic drug susceptibility testing on isolates with inferred rpoB mutations revealed that the 0.5 µg/mL critical concentration of RIF failed to detect most borderline mutations when using the BACTEC MGIT 960 system.</p><p><strong>Conclusions: </strong>These findings emphasize the need for continuous surveillance and the integration of molecular and phenotypic methods to ensure an accurate detection and management of drug-resistant TB in high-burden settings.</p>","PeriodicalId":21199,"journal":{"name":"Revista da Sociedade Brasileira de Medicina Tropical","volume":"58 ","pages":"e01842025"},"PeriodicalIF":2.3,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12455751/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145131820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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