Pub Date : 2025-09-29eCollection Date: 2025-01-01DOI: 10.1590/0037-8682-0118-2025
Luciana Vilela Gomide, João Paulo Turri Brufatto, Thiago Jessé Kucarz, Paulo Eduardo Neves Ferreira Velho, Andréa Fernandes Eloy da Costa França
Background: Erythema nodosum leprosum (ENL) is an immunological inflammatory reaction requiring precise management. Recalcitrant cases, their refractoriness to conventional therapy, and the adverse effects of standard treatments underline the need to explore alternative therapeutic options.
Methods: We conducted a retrospective study of five patients treated with secukinumab between January 2023 and January 2025.
Results: Patients showed clinical improvement with a reduced ENL frequency, neuritis relief, and corticosteroid sparing.
Conclusions: Secukinumab appears to be a promising corticosteroid-sparing option for ENL, with a favorable safety profile. Further studies are required to confirm the efficacy and long-term safety of this treatment regimen.
{"title":"Managing leprosy reactions with secukinumab: Insights from a case series.","authors":"Luciana Vilela Gomide, João Paulo Turri Brufatto, Thiago Jessé Kucarz, Paulo Eduardo Neves Ferreira Velho, Andréa Fernandes Eloy da Costa França","doi":"10.1590/0037-8682-0118-2025","DOIUrl":"10.1590/0037-8682-0118-2025","url":null,"abstract":"<p><strong>Background: </strong>Erythema nodosum leprosum (ENL) is an immunological inflammatory reaction requiring precise management. Recalcitrant cases, their refractoriness to conventional therapy, and the adverse effects of standard treatments underline the need to explore alternative therapeutic options.</p><p><strong>Methods: </strong>We conducted a retrospective study of five patients treated with secukinumab between January 2023 and January 2025.</p><p><strong>Results: </strong>Patients showed clinical improvement with a reduced ENL frequency, neuritis relief, and corticosteroid sparing.</p><p><strong>Conclusions: </strong>Secukinumab appears to be a promising corticosteroid-sparing option for ENL, with a favorable safety profile. Further studies are required to confirm the efficacy and long-term safety of this treatment regimen.</p>","PeriodicalId":21199,"journal":{"name":"Revista da Sociedade Brasileira de Medicina Tropical","volume":"58 ","pages":"e01182025"},"PeriodicalIF":2.3,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12479038/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145207579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-29eCollection Date: 2025-01-01DOI: 10.1590/0037-8682-0065-2025
Karla Lange, Andrea Marchiol, Rafael Herazo, Marianela Menes, Carlota Monroy, Antonieta Rodas, Belter Alcántara, Karen Carrillo, María Jesús Pinazo
Background: Chagas disease remains a public health problem in Guatemala, with ongoing transmission, both regionally and globally. Diagnosis is complex and often inaccessible. This study evaluated the performance of rapid diagnostic tests for Trypanosoma cruzi infection in Jutiapa.
Methods: Three rapid tests were performed, and the results were compared with those of a diagnostic algorithm for chronic infection.
Results: Although all tests had high specificity, their sensitivities were suboptimal. The combined use of RDTs (Rapid Diagnostic Tests) slightly improved the sensitivity, but it remained below the ideal thresholds.
Conclusions: Further evaluation of RDTs is necessary to enhance access and simplify diagnostic algorithms.
{"title":"Performance evaluation of rapid diagnostic tests for Chagas disease in Jutiapa, Guatemala.","authors":"Karla Lange, Andrea Marchiol, Rafael Herazo, Marianela Menes, Carlota Monroy, Antonieta Rodas, Belter Alcántara, Karen Carrillo, María Jesús Pinazo","doi":"10.1590/0037-8682-0065-2025","DOIUrl":"10.1590/0037-8682-0065-2025","url":null,"abstract":"<p><strong>Background: </strong>Chagas disease remains a public health problem in Guatemala, with ongoing transmission, both regionally and globally. Diagnosis is complex and often inaccessible. This study evaluated the performance of rapid diagnostic tests for Trypanosoma cruzi infection in Jutiapa.</p><p><strong>Methods: </strong>Three rapid tests were performed, and the results were compared with those of a diagnostic algorithm for chronic infection.</p><p><strong>Results: </strong>Although all tests had high specificity, their sensitivities were suboptimal. The combined use of RDTs (Rapid Diagnostic Tests) slightly improved the sensitivity, but it remained below the ideal thresholds.</p><p><strong>Conclusions: </strong>Further evaluation of RDTs is necessary to enhance access and simplify diagnostic algorithms.</p>","PeriodicalId":21199,"journal":{"name":"Revista da Sociedade Brasileira de Medicina Tropical","volume":"58 ","pages":"e00652025"},"PeriodicalIF":2.3,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12479034/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145207589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-29eCollection Date: 2025-01-01DOI: 10.1590/0037-8682-0258-2025
Elif Gozgec, Cemile Altinkaya
{"title":"A rare case report of bezold abscess in a 9-month-old baby.","authors":"Elif Gozgec, Cemile Altinkaya","doi":"10.1590/0037-8682-0258-2025","DOIUrl":"10.1590/0037-8682-0258-2025","url":null,"abstract":"","PeriodicalId":21199,"journal":{"name":"Revista da Sociedade Brasileira de Medicina Tropical","volume":"58 ","pages":"e02582025"},"PeriodicalIF":2.3,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12479035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145207599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-29DOI: 10.1590/0037-8682-0221B-2023
[This corrects the article doi: 10.1590/0037-8682-0221-2023].
[这更正了文章doi: 10.1590/0037-8682-0221-2023]。
{"title":"Erratum.","authors":"","doi":"10.1590/0037-8682-0221B-2023","DOIUrl":"10.1590/0037-8682-0221B-2023","url":null,"abstract":"<p><p>[This corrects the article doi: 10.1590/0037-8682-0221-2023].</p>","PeriodicalId":21199,"journal":{"name":"Revista da Sociedade Brasileira de Medicina Tropical","volume":"58 ","pages":"e0221B2023"},"PeriodicalIF":2.3,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12479037/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145207564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-29eCollection Date: 2025-01-01DOI: 10.1590/0037-8682-0257-2025
Elif Gozgec, Muhammed Mukremin Bugdaci
{"title":"Orbital cellulitis following acute sinusitis in a neonate.","authors":"Elif Gozgec, Muhammed Mukremin Bugdaci","doi":"10.1590/0037-8682-0257-2025","DOIUrl":"10.1590/0037-8682-0257-2025","url":null,"abstract":"","PeriodicalId":21199,"journal":{"name":"Revista da Sociedade Brasileira de Medicina Tropical","volume":"58 ","pages":"e02572025"},"PeriodicalIF":2.3,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12479040/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145207610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-29eCollection Date: 2025-01-01DOI: 10.1590/0037-8682-0279-2025
M Alperen Kılıç, Hilal Kırmızıgül, Emre Emekli, Murat Tepe
{"title":"A Rare Case of Primary Musculoskeletal Hydatid Disease Involving the Deltoid Muscle and Humerus.","authors":"M Alperen Kılıç, Hilal Kırmızıgül, Emre Emekli, Murat Tepe","doi":"10.1590/0037-8682-0279-2025","DOIUrl":"10.1590/0037-8682-0279-2025","url":null,"abstract":"","PeriodicalId":21199,"journal":{"name":"Revista da Sociedade Brasileira de Medicina Tropical","volume":"58 ","pages":"e02792025"},"PeriodicalIF":2.3,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12479045/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145207463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-29eCollection Date: 2025-01-01DOI: 10.1590/0037-8682-0229-2025
Cemile Altınkaya, Adem Karaman
{"title":"A case of tuberculosis in the cavitary lesion suggestive of neoplasm.","authors":"Cemile Altınkaya, Adem Karaman","doi":"10.1590/0037-8682-0229-2025","DOIUrl":"10.1590/0037-8682-0229-2025","url":null,"abstract":"","PeriodicalId":21199,"journal":{"name":"Revista da Sociedade Brasileira de Medicina Tropical","volume":"58 ","pages":"e02292025"},"PeriodicalIF":2.3,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12479044/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145207480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-29eCollection Date: 2025-01-01DOI: 10.1590/0037-8682-0066-2025
Celal Yazıcı
{"title":"A Rare Cause of Granulomatous Lymphadenitis: Tularemia.","authors":"Celal Yazıcı","doi":"10.1590/0037-8682-0066-2025","DOIUrl":"10.1590/0037-8682-0066-2025","url":null,"abstract":"","PeriodicalId":21199,"journal":{"name":"Revista da Sociedade Brasileira de Medicina Tropical","volume":"58 ","pages":"e00662025"},"PeriodicalIF":2.3,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12479036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145207542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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